A family of very small viruses containing circular, single-stranded DNA and possessing no envelope. The modes of transmission are not known.
Virus diseases caused by the CIRCOVIRIDAE.
A species of non-enveloped DNA virus in the genus ANELLOVIRUS, associated with BLOOD TRANSFUSIONS; and HEPATITIS. However, no etiological role has been found for TTV in hepatitis.
A genus of the family CIRCOVIRIDAE that infects SWINE; PSITTACINES; and non-psittacine BIRDS. Species include Beak and feather disease virus causing a fatal disease in psittacine birds, and Porcine circovirus causing postweaning multisystemic wasting syndrome in pigs (PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME).
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A condition of involuntary weight loss of greater then 10% of baseline body weight. It is characterized by atrophy of muscles and depletion of lean body mass. Wasting is a sign of MALNUTRITION as a result of inadequate dietary intake, malabsorption, or hypermetabolism.
The type species of GYROVIRUS, a small, non-enveloped DNA virus originally isolated from contaminated vaccines in Japan. It causes chicken infectious anemia and may possibly play a key role in hemorrhagic anemia syndrome, anemia dermatitis, and blue wing disease.
A worldwide emerging disease of weaned piglets first recognized in swine herds in western Canada in 1997. This syndrome is characterized by progressive weight loss, rapid (tachypnea) and difficult (dyspnea) breathing, and yellowing of skin. PMWS is caused by PORCINE CIRCOVIRUS infection, specifically type 2 or PCV-2.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Travel beyond the earth's atmosphere.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Substances that are recognized by the immune system and induce an immune reaction.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Ultrastructure of porcine circovirus in persistently infected PK-15 cells. (1/285)

The ultrastructure of porcine circovirus was examined in persistently infected porcine kidney (PK)-15 cells. Virus-infected PK-15 cells had large numbers of intracytoplasmic inclusions, and a few cells had intranuclear inclusions. Intracytoplasmic inclusions were dispersed throughout the cytoplasm but were most numerous in the perinuclear cytoplasm. Inclusion were of various sizes, round to oval, and electron dense and were of two general types. Inclusions of the first type were small (0.1-0.5 microm diameter), not surrounded by trilaminar membranes, and granular with indistinct margins that blended with surrounding cytoplasm. Some contained 12+/-2-nm-diameter icosahedral virions in loose aggregates or rarely forming paracrystalline arrays. Small inclusions could be sites of viral assembly or maturation. Intracytoplasmic inclusions of the second type were larger (0.5-5.0 microm diameter) and more numerous and had abrupt margins surrounded by trilaminar membranes. They were more electron dense than small inclusions and were heterogeneous, containing various proportions of aggregated virions, electron-dense crystalline lamellae of 5 nm periodicity, and/or whorls of myelinoid membranes. Virions usually formed paracrystalline arrays and occasionally were loosely aggregated. Larger inclusions were typical of autophagolysosomes. Intranuclear inclusions were not membrane bound and were often associated with reticulated nucleoli or aggregates of heterochromatin. Some inclusions were irregularly shaped aggregates of indistinct, circular 10-12-nm-diameter viruslike particles. Others were 0.1-1.0 microm in diameter, round or ring shaped, dense, and finely granular, with sharply demarcated margins.  (+info)

Observations on pigeon circovirus infection in Ontario. (2/285)

Subclinical pigeon circovirus infection was diagnosed in 1-day-old to 6-week-old birds from a loft with no history of clinical disease. Pigeons from other lofts presented with various illnesses and were found at necropsy to be concurrently infected with pigeon circovirus.  (+info)

Electron microscopical observations of psittacine beak and feather disease in an Umbrella cockatoo (Cacatua alba). (3/285)

Psittacine beak and feather disease (PBFD) was diagnosed in an umbrella cockatoo (Cacatua alba) with severe feather dystrophy and loss. Electron microscopically, the intranuclear and intracytoplasmic inclusion bodies observed by light microscopy were composed of viral particles forming paracrystalline arrays, whorls, semicircles or concentric circles. Recovered viral particles from the skin and feather follicle tracts were icosahedral and 15 to 20 nm in diameter.  (+info)

Detection of porcine circovirus from lesions of a pig with wasting disease in Japan. (4/285)

A wasting disease characterized by progressive weight loss and dyspnea has been observed in weaning pigs on a farm in Yamagata Prefecture in 1998. Histopathologic findings in an affected pig were bronchointerstitial pneumonia and intracytoplasmic clusters of basophilic inclusions in macrophages of lymph nodes, which were similar to those in pigs with postweaning multisystemic wasting syndrome (PMWS) recently reported in North America and Europe. Porcine circovirus (PCV)-like particles were observed in bronchial lymph node of the pig by electron microscopy, and PCV antigens were detected in the lesions by immunohistochemical staining. PCV DNA was also detected in the lung and tonsil by PCR, and restriction fragment length polymorphism analysis of the PCR products with HinfI showed the same type of the PCV associated with PMWS (pmws PCV). Homology of nucleotide sequences between the PCR product and corresponding regions of published pmws PCV genomes was very high. These results indicated that virus detected in this study was pmws PCV. To our knowledge, this is the first report on the presence of pmws PCV in Japan.  (+info)

Multiplex PCR for detection and typing of porcine circoviruses. (5/285)

Sets of oligonucleotide primers were designed according to the sequences of the open reading frames (ORFs) ORF1 and ORF2 of the prototype nonpathogenic PK-15 strain of porcine circovirus (PCV) type 1 (PCV-1). By the PCR performed with the various primer sets, genomic DNA or RNA from other bacterial or viral pathogens of the respiratory tracts of pigs could not be amplified. A positive amplification reaction could be visualized with DNA extracted from a viral suspension containing as few as 10 viral particles per ml. No DNA fragment could be amplified from lysates of continuous porcine cell lines (PT, ST, and PFT cells) known to be negative for PCV. When tested with clinical samples from pigs, the results of the single PCR method showed nearly 93% (13 of 14 samples) correlation with histopathological and immunohistochemical findings. Interestingly, subclinical PCV infections could be detected by single PCR with clinical samples that have been submitted from animals with irrelevant cases of respiratory and/or enteric problems. On the basis of the nucleotide sequences of PCV strains (PCV-2) recently associated with outbreaks of postweaning multisystemic wasting syndrome (PWMS) in Quebec, Canada, pig farms, other primers were designed from the PCV-1 genome, and these primers failed to amplify genomic fragments specific to the ORF1 or ORF2 genes of clinical isolates associated with PWMS but amplified DNA from the PCV-1 strain. Two rapid multiplex PCR (mPCR) methods have been developed to distinguish between both genotypes of PCV. By those two mPCR methods, (i) species-specific primer pairs were used to amplify a DNA fragment of 488 bp specific for the ORF2 genes of both genotypes, whereas a 375-bp fragment was amplified from the ORF1 gene of the PCV-1 strain only, or (ii) species-specific primer pairs were used to amplify a DNA fragment of 646 bp specific for the ORF1 genes of both genotypes, whereas a 425-bp fragment was amplified from the ORF2 gene of the PCV-1 strain only. By both mPCR methods, a PCV-2 infection was demonstrated in tissues of 94.2% (33 of 35) of the sick pigs tested, in agreement with previous findings showing the close association of this new genotype of PCV with outbreaks of PMWS in Europe and North America. On the other hand, a PCV-1 infection was confirmed in only 5.7% (2 of 35) of the pigs, and confirmation of a mixed infection with PCV-2 was obtained by a single PCR with PCV-2-specific primers.  (+info)

PCR detection and characterization of type-2 porcine circovirus. (6/285)

A polymerase chain reaction (PCR) assay was developed for detecting porcine circovirus (PCV). The assay readily detected type-2 PCV (PCV-2) and type-1 PCV (PCV-1). The PCR primers were designed based on DNA sequences conserved in all reported PCV genomes. Type 1 PCV and type 2 PCV both produced 438 bp amplification products, which were easily identified and differentiated from one another by restriction fragment length polymorphism (RFLP) analysis. Porcine circovirus was detected in 55% (931/1693) of randomly tested pigs with various clinical signs and lesions, most of which were difficult to differentiate from those associated with porcine reproductive and respiratory syndrome (PRRS). The PCR products from all positive clinical samples were identified by RFLP to be only PCV-2; DNA tested by PCR was extracted directly from one or more of lung, mesenteric or mediastinal lymph nodes, and tonsil. Type 2 PCV was also detected in 6% (2/34) of DNA extracted directly from semen of randomly chosen healthy boars. Positive PCR reactions from 554 diseased pigs were characterized by RFLP and categorized into 5 different profiles (A-E), of which 82.8% were PCV-2A (456/554), 3.0% were PCV-2B (17/554), 9.9% were PCV-2C (55/554), 1.1% were PCV-2D (6/554), and 3.2% were PCV-2E (18/554). The complete genomic nucleotide sequences of PCV-2A, B, C, D, and E were determined and found to have at least 95% homology compared with one another and with all other PCV-2 found in the GenBank database. All PCV-2 had less than 76% homology with PCV-1. This PCR assay will hopefully be useful to veterinary diagnostic laboratories for routine testing and surveillance of infection with PCV-2. The RFLP profiling system might be useful for preliminary characterization and identification of PCV isolates and might also benefit studies on the molecular epidemiology of PCV.  (+info)

Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction. (7/285)

This report describes the first diagnosis of porcine circovirus (PCV) infection in weaned pigs with postweaning multisystemic wasting syndrome in Korea by immunohistochemistry and polymerase chain reaction. The most unique lesions were multifocal granulomatous inflammation affecting lymph nodes, liver, and spleen, characterized by infiltrates of epithelioid macrophages and multinucleated giant cells. Circoviral antigen was detected in formalin-fixed sections and was usually present in large, round, dendritic cells in the white pulp of spleen and remnants of follicles in lymph nodes. Lymphoid follicles in the tonsils also contained PCV antigen. A 530-bp DNA fragment of circovirus was successfully amplified from all tested lymph nodes, liver, and spleen.  (+info)

High prevalence of TT virus DNA in human saliva and semen. (8/285)

Using the PCR assay, we found a high prevalence of TT virus (TTV) DNA in saliva and semen from patients who were seropositive for TTV. This finding suggests that the presence of TTV in body fluids other than serum may affect the routes of viral transmission.  (+info)

Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.. 0 Comments. ...
1. Meehan BM, McNeilly F, Todd D, Kennedy S, Jewhurst VA, Ellis JA, Hassard LE, Clark EG, Haines DM, Allan GM. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J Gen Virol. 1998;79:2171-2179.. 2. Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Vet J. 2005;169:326-336.. 3. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet J. 2004;168:41-49.. 4. Chae C. Commercial porcine circovirus type 2 vaccines: Efficacy and clinical application. Vet J. 2012;194:151-157.. 5. Chae C. Porcine circovirus type 2 and its associated disease in Korea. Virus Res. 2012;164:107-113.. 6. Fenaux M, Opriessnig T, Halbur PG, Elvinger F, Meng XJ. A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. J Virol. 2004;78:6297-6303.. 7. Chow SC, ...
Porcine circovirus-associated diseases (PCVAD), caused by porcine circovirus type 2 (PCV2), threaten the pig industry worldwide. Five genotypes of PCV2 were recently identified: PCV2a, PCV2b, PCV2c, PCV2d and PCV2e. In addition, a novel porcine circovirus from a case of a sow with dermatitis, nephropathy syndrome and reproductive failure has been identified based on metagenomic analysis and classified as porcine circovirus type 3 (PCV3). Therefore, the current study was conducted to determine the prevalence and genetic characteristics of PCV2 and PCV3 in clinical samples. A total of 471 samples (161 tissue samples of lungs and lymph nodes from 34 farms and 310 serum samples from 47 farms) were tested for PCV2. Among them, 171 samples from 59 farms that had been positive for PCV2 were genotyped. Another 690 samples (296 tissue samples of lungs and lymph nodes from 91 farms, 108 samples of aborted foetuses from 26 farms, and 286 serum samples from 47 farms) were tested for PCV3. Based on PCV2 genotyping
TY - JOUR. T1 - Porcine circovirus type 2 (PCV2) infections: Clinical signs, pathology and laboratory diagnosis. AU - Segalés, Joaquim. PY - 2012/3/1. Y1 - 2012/3/1. N2 - Clinical signs and pathological features are still the corner-stones to suspect and diagnose overt disease associated with PCV2 infection. The clinico-pathological scope of this viral infection has been expanded over time. From the initial description of postweaning multisystemic wasting syndrome, some enteric, respiratory and reproductive disorders have been subsequently linked with PCV2. Porcine dermatitis and nephropathy syndrome, an immunocomplex disease, has also been associated with infection by this virus. All together, these conditions have been grouped under the name of porcine circovirus diseases (PCVD) or porcine circovirus associated diseases (PCVAD). The precise mechanisms by which a PCV2 infected pig develops a PCV2 subclinical infection or a clinical PCVD/PCVAD are still to be fully elucidated, but inferences ...
Porcine circovirus type 2 (PCV2) causes postweaning multisystemic wasting syndrome (PMWS) in growing pigs but generally requires the presence of other infectious or non-infectious factors to produce the full clinical expression of disease. These factors remain to be identified, but management routines, concurrent infections and maternal immunity are thought to influence the risk for PMWS outbreak in swine herds. Pigs presenting with PMWS develop severe immunosuppression and the work of this thesis focuses on the interaction between PCV2 and the immune system of the pig in vivo and in vitro. Development of PMWS was studied in models for experimental infection in young pigs using coinfections with porcine parvovirus (PPV) or Escherichia coli. Three-day-old colostrum-deprived pigs infected with PCV2 and PPV developed severe PMWS, and a possible role for interleukin 10 as well as impaired production of antibodies to PCV2 in the development of disease was observed. Four-week-old colostrum fed pigs ...
Porcine circovirus type 2 (PCV2) belongs to the family Circoviridae, and is the causative agent of post-weaning multisystemic wasting syndrome (PMWS) in pigs. In this study, phylogenetic analyses of three complete PCV2 genomic sequences from Hong Kong suggest that natural recombination happened among different lineages of PCV2. A preliminary investigation of the parental strains of these potential recombinants was carried out using bootscanning. Statistical significance of this recombination event was tested and positions of the potential recombination breakpoints were estimated in a maximum-likelihood framework. The recombinant breakpoints were estimated to be located within the origin of replication (ori) and replicase (rep) gene of PCV2. Interestingly, several GenBank sequences of PCV2 in mainland China were found to have a recombination pattern similar to that of the potential PCV2 recombinants from Hong Kong, implying that this recombinant genotype might already be widespread within ...
Porcine circoviral disease (PCVD) and Porcine circovirus associated disease (PCVAD), is a disease seen in domestic pigs. This disease causes illness in piglets, with clinical signs including progressive loss of body condition, visibly enlarged lymph nodes, difficulty in breathing, and sometimes diarrhea, pale skin, and jaundice. PCVD is very damaging to the pig-producing industry and has been reported worldwide. PCVD is caused by porcine circovirus type 2 (PCV-2). The North American industry endorses PCVAD and European use PCVD to describe this disease. Postweaning multisystemic wasting syndrome (PMWS) is the classic PCVD entity, caused by PCV-2. PCV-2 has a near universal distribution - present in most pig herds. In contrast, PMWS is more sporadic in its distribution. Experimental induction of PMWS has not been achieved by PCV-2 infection alone, using infectious DNA clones of the virus or a pure form of PCV-2 derived from infectious DNA clones. Therefore, it is assumed that PMWS is a ...
Porcine circovirus type 3 (PCV3) is a newly emerging circovirus that might be associated with porcine dermatitis and nephropathy syndrome, reproductive failure, and cardiac and multisystemic inflammation. To aid the prevention and control of the infectious disease caused by PCV3, we developed a novel isothermal amplification assay using polymerase spiral reaction (PSR), which allows the visual detection of preserved strains and clinical samples. This assay precisely amplified the PCV3 genome with the use of a water bath at 62 °C for 50 min. The detection limit was found to be 1.13 × 102 copies/μL by gel electrophoresis or with the use of a visible dye (an indicator comprising phenol red and cresol red). No cross-reaction with other porcine infectious viruses was observed. The detection results for 23 PCV3-positive samples by PSR were in accordance with loop-mediated isothermal amplification (LAMP) assay. The detection rate of the PSR assay for PCV3 positivity of clinical samples was 68/97, which was
TY - JOUR. T1 - Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue. AU - Sorden, Steven D.. AU - Harms, Perry A.. AU - Nawagitgul, Porntippa. AU - Cavanaugh, David. AU - Paul, Prem S.. PY - 1999/11. Y1 - 1999/11. N2 - An immunohistochemical method for the detection of type 2 porcine circovirus (PCV2) in paraffin-embedded tissue was developed. Rabbits were inoculated with purified PCV2 to obtain a polyclonal antiserum. Antiserum was applied to sections of porcine tissue that contained lesions consistent with postweaning multisystemic wasting syndrome and in which PCV2 genome had been demonstrated by in situ hybridization. In all cases (18/18), the density and distribution of positive cells detected by in situ hybridization or immunohistochemistry were identical. The immunohistochemical method is more rapid and less expensive than in situ hybridization and is thus more suitable for routine ...
IDENTIFICATION AND USE: Porcine circoviruses are small, icosahedral viruses that were discovered in 1974 as contaminants of a porcine kidney cell line. They were later called circoviruses when their genome was found to be a circular, single-stranded DNA molecule. Upon entry into cells, the viral ssDNA genome enters the nucleus where it is made double-stranded by host enzymes. It is then transcribed by host RNA polymerase II to form mRNAs that are translated into viral proteins. There is some evidence that circoviruses might have evolved from a plant virus that switched hosts and then recombined with a picorna-like virus.. Porcine circoviruses are classified in the Circoviridae family, which contains two genera, Circovirus and Gyrovirus. There are two porcine circoviruses, PCV-1 and PCV-2; only the latter causes disease in pigs. Infection probably occurs via oral and respiratory routes, and leads to various diseases including postweaning multisystemic wasting syndrome, and porcine dermatitis and ...
Porcine circovirus type 2 Capsid antibody for IHC, IHC-P, WB. Anti-Porcine circovirus type 2 Capsid pAb (GTX128120) is tested in Porcine circovirus type 2 samples. 100% Ab-Assurance.
Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233 amino acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs, and compare these responses to pigs diagnosed with porcine circovirus-associated disease (PCVAD). The approach was to react porcine sera with different CP polypeptide fragments that each contained one or more immunoreactive regions. Expression of polypeptides was performed using E.coli. Initial results showed that sera from vaccinated pigs preferentially recognized only the largest CP(43-233) polypeptide fragment and showed low levels of binding to other CP polypeptide fragments. The results of sera from pigs diagnosed with PMWS showed only minimal reactivity with CP polypeptide fragments, including the ...
Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), whereas the ubiquitous porcine circovirus type 1 (PCV1) is nonpathogenic for pigs. Since its initial detection in a Canadian commercial swine herd in 1991, PMWS has been detected in all swine producing regions of the world and is now a serious economic problem to the swine industry. The objectives of this dissertation were to biologically, genetically and experimentally characterize both PCV1 and PCV2, to identify the genetic determinant(s) for virulence and replication, and to develop an effective genetically-engineered vaccine against PCV2 infection and PMWS. The genetic heterogeneity of PCV2 and PCV1 isolates from different geographic origins were determined. We found that, although PCV1 and PCV2 genomes were very conserved, some minor genomic variation exists among PCV1 isolates and PCV2 isolates. The nonpathogenic PCV1 and pathogenic PCV2 share only about 76% nucleotide ...
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a serious economic problem to the swine industry worldwide leading to significant negative impacts on profitability of pork production. In this study we have demonstrated that PCV2 capsid (Cap) protein based virus-like particles (VLPs) were efficiently produced in yeast S. cerevisiae and induced production of monoclonal antibodies (MAbs) reactive with virus-infected cells. Moreover, PCV2 Cap VLPs served as a highly specific recombinant antigen for the development of an indirect IgG PCV2 Cap VLP-based ELISA for the detection of virus-specific IgG antibodies in swine sera. Four hundred-nine serum samples collected from pigs in Lithuania were tested for PCV2-specific IgG to determine the sensitivity and specificity of the newly developed ELISA in
Porcine circovirus type 2 (PCV2) associated reproductive disease was diagnosed in a herd containing only gilts. A single case of abortion occurred and no other disorder was evident in the herd. PCV2 antigen and/or DNA were detected in two aborted fetuses. One of the fetuses, revealing both PCV2 DNA and antigen, presented multinucleated giant cells, severe vascular lesions (intramural oedema, fibrinoid necrosis, mild lympho-histiocytic vasculitis, fibrin thrombi) and mild non-suppurative inflammation in the lungs. Other abortifacient infections were not found. This is the only report of PCV2-induced abortion in Hungary since 1999, when PCV2-associated disease was first discovered in the country. ...
Porcine circovirus type 3 (PCV-3) had posed a potential threat to the swine industry since its discovery in the United States in 2015. The Shanxi province had a wide range of large-scale pig farms in China, but the transmission of PCV-3 was unclear. T
Porcine circovirus type 2 (PCV2) vaccination leads to reduced mortality, increased growth rate, inconsistent effects on feed efficiency and no impacts on carcass traits but the effects on nursery performance are product-dependent, according to Dr Steve Dritz of Kansas State University.
Coreplication of the major genotype group members of porcine circovirus type 2 as a prerequisite to coevolution may explain the variable disease ...
Baltimore Classification== ===Higher order taxa=== Viruses; ssDNA viruses; Circoviridae; Circovirus ===Species=== Beak and feather disease virus, Canary circovirus, Goose circovirus ==Description and Significance== Circoviruses are very small non-enveloped icosahedral viruses with a single stranded circular DNA genome. They have been described in pigs (porcine circovirus, PCV), chickens (chicken anemia virua, ChAV), psittacines (psittacine beak and feather disease virus, PBFD) and pigeons. The virus targets the lymphoid tissue and causes immunosuppression in the host. Circoviruses are the smallest pathogenic DNA viruses that have been identified and characterized in animals. ==Genome Structure== The genome of the circovirus is monomeric. It is unsegmented and contains a single molecule of circular, ambisense, sinle-stranded DNA that forms a covalently closed circle. The complete genome is 1800-2000 nucleotides long and the genome has a guanine+cytosine content of 48.4-53.1 %. (source: ...
Circoviridae is a family of viruses. Birds and mammals serve as natural hosts. There are currently 70 species in this family, divided among 2 genera. Diseases associated with this family include: PCV-2: postweaning multisystemic wasting syndrome; CAV: chicken infectious anemia. Viruses in the family Circoviridae are non-enveloped, with icosahedral and round geometries, and T=1 symmetry. The diameter is around 20 nm. Genomes are circular and non-segmented, around 3.8kb in length. The capsid consists of 12 pentagonal trumpet shaped pentamers. There are two main open reading frames arranged in opposite directions that encode the replication (Rep) and capsid (Cap) proteins. Alternative start codons are common in the avian species. Viral replication is nuclear. Entry into the host cell is achieved by penetration into the host cell. Replication follows the ssDNA rolling circle model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits ...
Two types of porcine circovirus (PCV) exist, referred to as PCV1 and PCV2. PCV2 has been associated with disease syndromes in pigs, including that designated postweaning multisystemic wasting syndrome (PMWS), which has been identified in all regions of the world bar Australia (Hamel et al., 1998; Allan et al., 1999a; Onuki et al., 1999; Martelli et al., 2000; Kyriakis et al., 2000; Wellenberg et al., 2000; Done et al., 2001; Trujano et al., 2001; Saradell et al., 2004; Castro et al., 2004; Jemersic et al., 2004; Maldonado et al., 2004; Wang et al., 2004; Motovski and Segales, 2004; Garkavenko et al., 2005). PMWS affects young weaner pigs and results in weight loss, tachypnea, dyspnea, enlarged lymph nodes and jaundice (Harding, 1998). PCV2 may also cause or contribute to other swine diseases such as congential tremors (CT) (Stevenson et al., 1999), porcine dermatitis and nephropathy syndrome (PDNS) (Rosell et al., 2000), reproductive failure (Meehan et al., 2001) and several other emerging ...
Combination vaccine gives swine industry effective, convenient option. FLORHAM PARK, N.J., Aug. 20, 2014 - Fostera™ PCV MH - the porcine circovirus (PCV) and Mycoplasma hyopneumoniae (M. hyo) combination vaccine that was built from the ground up by Zoetis - now has the longest demonstrated duration of immunity (DOI) to help protect pigs from porcine circovirus-associated disease (PCVAD) caused by PCV Type 2 (PCV2). The U.S. Department of Agriculture has granted the combination vaccine the extended label claim of at least 23 weeks of protection against PCV2, which is three weeks longer than any other PCV2 vaccine on the market.. PCVAD continues to be one of the most economically harmful swine diseases. Affected pigs suffer from progressive weight loss, increased mortality and other clinical impacts, which takes a toll on producers productivity and profitability, said Darrell Neuberger, DVM, Pork Technical Services, Zoetis. Now, with a vaccine that offers at least 23 weeks of immunity, ...
1111767DNAPorcine circovirus 1accagcgcac ttcggcagcg gcagcacctc ggcagcacct cagcagcaac atgcccagca 60agaagagtgg aagaagcgga ccccaaccac ataaaaggtg ggtgttcacg ctgaataatc 120cttccgaaga cgagcgcaag aaaatacggg agctcccaat ctccctattt gattatttta 180ttgttggcga ggaaggtaat gaggagggcc gaacacccca cctacagggg ttcgctaatt 240ttgtgaagaa gcaaactttt aataaagtga agtggtattt tggtgcccgc tgccacatcg 300agaaagcgaa aggaacagat cagcagaata aagaatattg cagtaaagaa ggcaacttac 360tgatagaatg tggagctcct agatctcaag gacaacggag tgacctctct actgctgtga 420gtaccttgtt ggagagcggg agtctggtga ccgttgcaga gcagcaccct gtaacgtttg 480tcagaaattt ccgcgggctg gctgaacttt tgaaagtgag cgggaaaatg cagaagcgtg 540attggaagac gaatgtacac gtcattgtgg ggccacctgg gtgtggcaaa agcaaatggg 600ctgctaattt tgcagacccg gaaaccacat actggaaacc acctagaaac aagtggtggg 660atggttacca tggtgaagaa gtggttgtta ttgatgactt ttatggctgg ctgccgtggg 720atgatctact gagactctgt gatcgatatc ctttgactgt tgagactaaa ggtggaactg 780tacctttttt ggcccgcagt attctgatta ccagcaatca gaccccgttg gaatggtact 840cctcaactgc ...
Animal circoviruses belong to the Circovirus genus of the Circoviridae family. Nowadays, only swine and birds were identified as circovirus hosts. Circoviruses have a single-stranded circular genome of approximately 2000 nucleotide long. DNA of these viruses possesses : (i) a nonanucleotide sequence essential for replication, flanked by inverted repeat sequences, a palindrome that has the potential to form a stem-loop structure and (ii) two major ORFs, located on the viral and complementary strands, which encode respectively the replication-associated protein (Rep) and the capsid protein (Cap). All the circoviruses described at the present time, except porcine circovirus of type 1, are associated with immunosuppressive or immunodepressive diseases. Histopathological lesions such as cytoplasmic inclusions of virus in histiocytic cells and T and B lymphocyte depletion in lymphoid organs, are commonly noticed. No medical prophylaxis of circovirus infections is currently available.. ...
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Zoetis launched Fostera PCV MH on the US market. The vaccine is a one-bottle, one-dose combination vaccine that helps protect swine from Porcine Circovirus-associated disease (PCVAD) and enzootic pneumonia caused by Mycoplasma hyopneumoniae (M. hyo).
Supplementary MaterialsS1 Document: Protocol (Danish). patients. Five-hundred and eighty-eight positive patients had been assessed for eligibility, which 559 had been excluded ahead of randomization. The Mouse monoclonal to MYST1 three significant reasons for exclusion had been duration of diarrhoea much longer than 21 times (n = 124), prior antibiotic treatment (n = 113), and co-pathogens in stools (n = 87). For that reason, 24 sufferers finished the trial with either azithromycin (n = 12) or placebo (n = 12). Both groupings provided symptoms of gentle, prolonged diarrhoea with a mean duration of 18 times (95% CI: 16C19). One individual in the azithromycin group and four from the placebo group thought we would continue with crossover medicine after the preliminary ten-time period. In the azithromycin group, there is a mean of a week (95% CI: 5C9) to scientific treat and for the placebo group it had been ten days (95% CI: 6C14) (OR3 (95% CI: -7C1). We observed no distinctions in every examined ...
article{326621, abstract = {Stimulation of the porcine immune system causes increased replication of porcine circovirus 2 (PCV2) in vivo. In the present study, we investigated whether various cytokines (interleukin-1 [IL-1], IL-6, IL-10, tumor necrosis factor-alpha [TNF-alpha], interferon-alpha [IFN-alpha], and IFN-gamma) are able to influence PCV2 infection in vitro. No changes were observed in IL-1, IL-6, TNF-alpha, or IL-10-treated cells. However, it was demonstrated that IFN-alpha and IFN-gamma influenced PCV2 infection in porcine kidney cells (PK-15) and porcine monocytic cells (3D4/31). IFN-gamma added to the culture medium before, during, or after inoculation increased the number of PCV2 antigen-positive cells, respectively, by 418%, 171%, and 691% in PK-15 cells and by 706%, 114%, and 423% in 3D4/31 cells. IFN-alpha pretreatment decreased the number of infected PK-15 cells. When it was added after inoculation, IFN-alpha enhanced PCV2 infection by 529% in PK-15 cells and by 308% in 3D4/31 ...
Porcine Circovirus 2 (PCV2) has been intriguing pig producers and scientists alike as it proved difficult to identify both the disease's origins and triggers. In this third episode of the series 'PCVD - From pathogenesis to protection', Pig Progress launches an attempt to unveil as many mysteries as possible that surround PCV2.
Last week we discussed measures being taken in Europe for treatment and control of porcine circovirus type-2 (PCV-2). This week we will consider
posted April 1, 2008 Boehringer Ingelheim Vetmedica Inc. again requests proposals for studies investigating porcine circovirus-associated
Protection Against Evolving Virus. DURHAM, N.C., March 3, 2018 - Zoetis has introduced Fostera® Gold PCV MH, the U.S. pork industrys first vaccine to include two genotypes of porcine circovirus type 2 (PCV2) - 2a and 2b.. Together, the two genotypes provide the broadest range of protection against evolving PCV2 viruses in U.S. swine herds. The vaccines efficacy against 2d - the most prevalent PCV2 genotype - was demonstrated in a large field trial.. Were pleased to introduce a vaccine that brings real value to the U.S. pork industry - one that provides broader protection against PCV2 genotypes and, more importantly, helps to minimize performance problems due to the virus, reduce monetary losses for producers and benefit animal welfare, said Lucina Galina, DVM, PhD, director, swine technical services, Zoetis.. The duration of immunity (DOI) with Fostera Gold PCV MH is at least 23 weeks for PCV and Mycoplasma hyopneumoniae (M. hyo), which means the vaccine will protect most herds through the ...
Porcine circovirus type 2 (PCV2), a highly prevalent, economically important swine pathogen is classified into different genotypes (PCV2a-f) based on phylogenetic analysis. Since the introduction of extensive vaccination programs, at least two major shifts have been observed in the prevalence of PCV2 genotypes. The first genotype shift from 2a towards 2b occurred around 2003, while in recent years, we are witnessing the second change in genotype prevalence from the predominant 2b towards 2d. In this study, a PCV2d-2 isolate was characterized as a potential challenge virus for the evaluation of PCV2 vaccine efficacy. Ten-week-old pigs carrying low to moderate levels of maternally derived antibodies to PCV2 were infected with the isolate by the nasal route. Over the next 4 weeks post-infection, the pigs were monitored for the presence of viremia, fecal virus excretion, and humoral immune responses. At the end of the post-infection observation period, samples were taken from the mediastinal and mesenteric
UK - Researchers at the Royal Veterinary College (RVC) have developed an oral vaccine against porcine circovirus type 2 (PCV2) based on the yeast Saccharomyces cerevisiae.
Average daily gain (ADG) and viral load (VL) were evaluated for pigs co-infected with porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) and porcine circovirus type 2b (PCV2b). Pigs were pre-selected for WUR genotype (a marker on chromosome 4 associated with weight gain and VL under PRRSV-challenge), half were vaccinated for PRRS, and half were not. Results indicate that vaccination for PRRS resulted in slower growth prior to co-infection and that the AB WUR genotype was associated with faster growth prior to co-infection, lower PRRS VL, and lower PCV2b VL in vaccinated pigs.
Factors to be considered for deciding the optimal time of vaccination. Comparison of different vaccination programs in PCV2 subclinically infected piglets.
A long-established epidemic of enteritis, caused by an unidentified pathogen distinct from parvovirus, has now been recognized in mink. In 2013, we identified a novel circovirus by degenerate PCR and fully sequenced its genome. This virus differs substantially from currently known members of the genus Circovirus and represents a new species.
Background Diarrhea is one of the most common clinical symptoms reported in companion animal clinics. Dog circovirus (DogCV) is a new mammalian circovirus that is considered to be a cause of...
El present treball es centra en lestudi de la producció de proteïnes recombinants en línies cel·∙lulars de mamífer. Concretament, sha realitzat lestudi de tres estratègies de bioprocés, totes elles basades en el cultiu de cèl·∙lules HEK293. Com a proteïna model per a lexpressió de proteïnes heteròlogues sha triat la proteïna CapPCV2, la qual conforma la càpsida viral del Circovirus porcí serotip 2 (PCV2). Aquest virus és lagent causal de PCVDS (porcine circovirus diseases o malaties derivades de circovirus porcí). Aquest terme engloba un conjunt de malalties i síndromes que tenen un elevat impacte econòmic en la indústria porcina. El projecte sha enfocat des de la perspectiva de desenvolupament i optimització del bioprocés i, en conseqüència, lincrement de la producció volumètrica ha estat la força impulsora de tot el treball. En primer lloc es presenten els estudis per a la selecció del medi de cultiu i suplements nutricionals. El creixement cel·∙lular
Ohio Ag Dept issued warning on Canine Circovirus, a contagious disease that has spread, killing 6 more dogs, but is there more to be feared than this virus …
En trece cap tulos se revisan las principales enfermedades que afectan al ganado porcino, tanto en producci n intensiva como extensiva. Realizado grandes especialistas en enfermedades infecciosas del ganado porcino de Espa a
2. Tischer I, Mields W, Wolff D, Vagt M, Griem W. Studies on epidemiology and pathogenicity of porcine circovirus. Arch Virol. 1986;91:271-276.. 3. Allan GM, McNeilly F, Cassidy JP, Reilly GA, Adair B, Ellis WA, McNulty MS. Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material. Vet Microbiol. 1995;44:49-64.. 5. Segalés J, Sitjar M, Domingo M, Dee S, Del Pozo M, Noval R, Sacristan C, De las Heras A, Ferro A, Latimer KS. First report of post-weaning multisystemic wasting syndrome in pigs in Spain. Vet Rec. 1997;141:600-601.. 6. Allan GM, Kennedy S, McNeilly F, Foster JC, Ellis JA, Krakowka SJ, Meehan BM, Adair BM. Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus. J Comp Pathol. 1999;121:1-11.. 7. Balasch M, Segalés J, Rosell C, Domingo M, Mankertz A, Urniza A, Plana-Durán J. Experimental inoculation of conventional pigs with tissue homogenates from ...
The study conducts the first phylogenetic analysis of PCV2 in Chile. PCV2 isolated from Chilean intensive swine farms, covering over the 90% of the pork production, resulting a complete national perspective of PCV2. The results confirm the high presence of PCV2b (52%) and less represented PCV2a (14%). Surprisingly, 34% of sequences were PCV2a/PCV2d recombinant viruses. The no amplification of these 10 sequences by the selective PCR was further explained due to these primers were not able to amplified PCV2d, the major parenteral of these viruses. Furthermore, we were not able to detect PCV2d variant in the Chilean PCV2 diversity even if was the major parent of the recombinant viruses, probably this event occurred years before and the recombinant remained. PCV2a and PCV2b, and the recombinant viruses were found since 2005. Nevertheless, were not observed geographical, temporal and other patterns, most likely due to there is not enough sequences per farm.. Recently, a large-scale study determinates ...
12.Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang, Dewen Tong*, p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research, 2016. 47(1): p. 120-131.. 13.Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong*, Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.. 14.Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong*, CD40 Ligand and GMCSF coexpression enhance the immune responses and protective efficacy of PCV2 adenovirus vaccine. Viral Immunology, 2016. 29(3): p. 148-158.. 15.Xiaomin Zhao, Hailing Xiang, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang, Dewen Tong*, Porcine parvovirus infection activates mitochondria-mediated apoptotic ...
Read Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
A blinded interlaboratory assessment of the diagnostic agreement and accuracy of serologic tests for routine detection of antibodies against Porcine circovirus-2 (PCV-2), including indirect fluorescent antibody tests (IFATs) and enzyme-linked immunosorbent assays (ELISAs) was conducted in 7 North American laboratories.
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non
Porcine diseases associated with porcine circovirus 2 (PCV-2) infection have resulted in significant economic losses worldwide. A real-time recombinase polymerase amplification (RPA) assay was develop
Read Genetic characterization of type 2 porcine circoviruses detected in Hungarian wild boars, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
The chicken anaemia virus is associated with increased mortality rates amongst chickens. This study makes considerable progress towards developing a defined attenuated vaccine against the virus.
Gentaur molecular products has all kinds of products like :search , GeneRiver \ Chicken Anaemia Virus \ K 132 for more molecular products just contact us
Fast Shipping. Great Low Price. Circumvent PCV-M G2 for swine is used in the prevention of viremia, the reduction of virus shedding, the reduction of lymphoid infection caused by porcine circovirus Type 2 (PCV2), and in the reduction of lung lesions due to Mycoplasma hyopneumoniae. Circumvent PCV-M G2 is approved for piglets as early as 3 days of age. Convenient one or two dose administration options with five month PCV2 duration of immunity. Dosage Option 1: Give a single 2 ml dose IM to health
Viruses news In the middle of the worldwide pandemic crisis because of coronavirus, together with Chilean collegues working at the University of Concepción and at the University of Santiago de Chile (among others institutions), we recently published a new chimeric capsid protein as antigen for the treatment of the Porcine Circovirus Type 2 (PCV2) disease.…
Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide. It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as much as its association in disease with the Canine Parvovirus-2 (CPV-2). Here, we aim to confirm for the first time the presence of CanineCV in Colombia and to develop phylogenetic evolutive analyses of CanineCV in CPV-2 positive animals. DNA from samples were extracted and PCR, full genome sequencing and phylogenetic analysis was performed to detect and characterize CanineCV. From a total of 30 CPV-2 positive samples, 16.6% (n = 5) were positives for CanineCV. Sequencing analysis of Colombian CanineCV wild-type strains displayed high identity to each other (99.5-99.7% nt; 99.7% aa). The full genome phylogenetic analysis confirmed that worldwide reported CanineCV strains were separated into four distinct genotypes in addition to a European origin of the
MHYOSPHERE® PCV ID is the first intradermal & needle-free vaccine against M.hyo & Circovirus PCV2, all in one and ready-to-use in swine.
Vol 10: High yield production of pigeon circovirus capsid protein in the E. coli by evaluating the key parameters needed for protein expression.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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"Identification of a New Cyclovirus in Cerebrospinal Fluid of Patients with Acute Central Nervous System Infections". mBio. 4 (3 ... ICTV Online Report; Circoviridae ICTVdB Entry for Circoviridae Viralzone: Circoviridae (Articles with short description, Short ... Circoviridae is a family of DNA viruses. Birds and mammals serve as natural hosts. There are 101 species in this family, ... The family Circoviridae contains two genera-Circovirus and Cyclovirus. Genus Circovirus: type species: Porcine circovirus 1 ...
The overall infection rate was 33.29%. Ducks at 3-4 weeks of age where more susceptible to DuCV virus. Anas platyrhynchos, ... DuCV has been clustered in the Circoviridae family genus Circovirus, according to the eighth report of the International ... Infection with DuCV appears to cause growth disorders in ducks as well as eventual immunosuppression due to depletion of ... Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Circoviridae, ...
Animal viruses in Circoviridae are associated with many diseases, including respiratory illness, intestinal illness, and ... Parvoviruses are most widely known for causing a lethal infection in canids as well as causing fifth disease in humans. ... Centuries later, a circovirus infection that caused balding in birds was observed in Australia in 1888, marking the first ...
For example, some protect against infection with related viruses. In some mammal groups, including higher primates, retroviral ... Bornaviridae and Circoviridae families of viruses, and 12 million years for the Lentivirus genus of the Retroviridae family. ...
... viral infection, avian polyomavirus infection, adenovirus infection and herpesvirus infection in psittacine tissues using DNA ... The beak and feather disease virus (BFDV) is currently considered a member of the family Circoviridae. Like other circoviruses ... or parasitic infections often occur as a result of diminished immunity caused by a PBFD viral infection. Clinical signs in ... are generally due to secondary infections and may not be directly related to PBFD virus infections. Furthermore, not all ...
Zheng, MY; Lin, Y; Li, DJ; Ruan, HB; Chen, Y; Wu, TT (2010). "TTV and HPV co-infection in cervical smears of patients with ... While bearing some similarity to members of the group Circoviridae, it lacks sequence homology with any known viruses. It is ... Infection with these viruses tends to lead to lifelong viraemia and their possible association with disease remains under ... Despite that the link between TTV infection and a given pathology has not been shown, the hypothesis of a relation between ...
In older chickens, an infection with no apparent symptoms may cause reduced growth rates due to a poor feed conversion ratio. ... Markey, B; Leonard, F; Archambault, M; Cullinane, A; Maguire, D (2013). "Chapter 46: Circoviridae". Clinical veterinary ... Clinical signs of CAV infection are predominantly found in young chicks due to vertical transmission from the breeder hens ... Quinn, PJ; Markey, BK; Leonard, FC; Fitzpatrick, ES; Fanning, S (2015). "Chicken anaemia virus infection". Concise Review of ...
These animals have been noted to show high susceptibility to airway infections, but very little is known about their ... in particular the Circoviridae, members of the Parvoviridae , and a family of RNA viruses, the Tombusviridae. Suzuki A, Ueda K ... which tend to colonize but without causing the onset of infection. But during periods of immunosuppression these organisms can ...
... is a genus of viruses, in the family Circoviridae. Birds (such as pigeons and ducks) and pigs serve as natural hosts ... Marlier, D; Vindevogel, H (July 2006). "Viral infections in pigeons". Veterinary Journal. 172 (1): 40-51. doi:10.1016/j.tvjl. ...
Co-infections are also a common occurrence in animals afflicted with CaCV. Canine distempter and parvovirus (genotype 2) were ... It is a member of the Circoviridae family and the genus Circovirus. There are currently 11 species of known circoviruses that ... Two dogs died within a week of infection while the others were ill but able to recover. One of the bodies underwent laboratory ... Within the group of dogs that tested positive for CaCV, 68% of them had other co-infections of varying illnesses. There have ...
It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... Two examples include the Circoviridae and Parvoviridae. They replicate within the nucleus, and form a double-stranded DNA ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ... The Effects of Viral Infections and Viral Insulins on Host Metabolism". Annual Review of Virology. 8 (1): 373-391. doi:10.1146/ ...
However, viral infection by itself tends to cause only mild disease, and co-factors such as other infections or ... Circoviridae, Animal viral diseases, Unaccepted virus taxa, Swine diseases). ... For example, concurrent infection with porcine parvovirus or PRRS virus, or immunostimulation lead to increased replication of ... Testing of the other licensed vaccine against rotavirus infection, RotaTeq, also detected some components of both PCV-1 and PCV ...
Most viral infections of humans and other animals have incubation periods during which the infection causes no signs or ... The smallest-the ssDNA circoviruses, family Circoviridae-code for only two proteins and have a genome size of only two ... The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Smallpox infections have been eradicated. Vaccines are available to prevent over thirteen viral infections of humans, and more ...
Aditi; Shariff, M. (2019). "Nipah virus infection: A review". Epidemiology and Infection. 147: e95. doi:10.1017/ ... Circoviruses, family Circoviridae, are among the most diverse of all viruses. Like anelloviruses, circoviruses are not ... In late 2012, a vaccine was released to prevent infection in horses. Vaccine uptake has been low, with an estimated 11-17% of ... Bats' immune systems may have evolved to be more tolerant of stressors such as viral infections compared to other mammals. The ...
However, viral infection by itself tends to cause only mild disease, and co-factors such as other infections or ... Circoviridae). ... Wasting pigs is the most common sign of PMWS infection, ... Experimental induction of PMWS has not been achieved by PCV-2 infection alone, using infectious DNA clones of the virus or a ... Many pigs affected by the circovirus also seem to develop secondary bacterial infections, like Glässer disease (Haemophilus ...
... infection status), and its specific role if in a multicellular organism. Gene expression can be regulated at any step: from ... the parvoviridae and circoviridae are more than 40 to 50 million years old". Journal of Virology. 84 (23): 12458-62. doi: ...
... we identified 1,011 sequences corresponding to the capsid and Rep genes from the Circoviridae family. From a plasma sample ... bronchopulmonary infections, and parvovirus B19 and COVID-19 infections. In November 2021, 14 months after receiving pulsed ... Opriessnig T, Prickett JR, Madson DM, Shen HG, Juhan NM, Pogranichniy RR, et al. Porcine circovirus type 2 (PCV2)-infection and ... Central nervous system infections after solid organ transplantation. Curr Opin Infect Dis. 2021;34:207-16. DOIPubMedGoogle ...
Lum SH, Turner A, Guiver M, Bonney D, Martland T, Davies E, et al. An emerging opportunistic infection: fatal astrovirus (VA1/ ... Circoviridae); hemagglutinating encephalitis virus (Coronaviridae); and porcine parvovirus 1, 2, 4, and porcine bocavirus ( ... Wunderli W, Meerbach A, Güngör T, Berger C, Greiner O, Caduff R, et al. Astrovirus infection in hospitalized infants with ... and rarely encephalitis or disseminated infections (2,5-19). Astrovirus infections with central nervous system (CNS) ...
Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. Virus taxonomy. classification and nomenclature ... Spread of the infection seemed to be horizontal because mink were usually affected after a mink on the same farm became ill. ... Analysis of experimental mink enteritis virus infection in mink: in situ hybridization, serology, and histopathology. J Virol. ... Members of the family Circoviridae are nonenveloped, icosahedral viruses with diameters of 16-26 nm and a small, circular, ...
Persistent infection with chicken anaemia virus and some effects of highly virulent infectious bursal disease virus infection ... Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ ... Pathological and immunohistochemical study of chickens with co-infection of Marek's disease virus and chicken anaemia virus. ...
Picobirnavirus infections: viral persistence and zoonotic potential. Rev Med Virol. 2012;22:245-56. DOIPubMedGoogle Scholar ... Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA ... Emerging viral infections can be identified by using a viral metagenomics approach for clinical human material. Diarrhea ... In addition, specific viral infections were not identified in samples from the same gastroenteritis outbreaks. On the basis of ...
... we identified 1,011 sequences corresponding to the capsid and Rep genes from the Circoviridae family. From a plasma sample ... bronchopulmonary infections, and parvovirus B19 and COVID-19 infections. In November 2021, 14 months after receiving pulsed ... Opriessnig T, Prickett JR, Madson DM, Shen HG, Juhan NM, Pogranichniy RR, et al. Porcine circovirus type 2 (PCV2)-infection and ... Central nervous system infections after solid organ transplantation. Curr Opin Infect Dis. 2021;34:207-16. DOIPubMedGoogle ...
Picobirnavirus infections: viral persistence and zoonotic potential. Rev Med Virol. 2012;22:245-56. DOIPubMedGoogle Scholar ... Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA ...
Persistent infection with chicken anaemia virus and some effects of highly virulent infectious bursal disease virus infection ... Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ ... which might represent a putative short-lived acute infection with possible subsequent re-infection or just declines of the HGyV ... Evidence of HGyV Infections. No samples from 50 healthy blood donors studied yielded positive results for HGyV (Table 1). Of 4 ...
Persistent infection with chicken anaemia virus and some effects of highly virulent infectious bursal disease virus infection ... Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ ... Pathological and immunohistochemical study of chickens with co-infection of Marek's disease virus and chicken anaemia virus. ...
Persistent infection with chicken anaemia virus and some effects of highly virulent infectious bursal disease virus infection ... Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ ... Pathological and immunohistochemical study of chickens with co-infection of Marek's disease virus and chicken anaemia virus. ...
Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, Pathogenic simian immunodeficiency virus infection is associated ... circoviridae (2,127 reads), group A rotavirus (839 reads), adeno-associated virus (812 reads), picobirnavirus (274 reads), ... To identify other viral infections in this patient, the Tusavirus-positive sample was individually analyzed by the same ...
Although infection with CAV in birds is frequently associated with clinical signs and disease, the presence of HGyVs in ... family Circoviridae), possesses a genome of ≈2.3 kb, containing 3 major partially overlapping open reading frames, viral ...
infection = CIRCOVIRIDAE INFECTIONS. Allowable Qualifiers:. CH chemistry. CL classification. DE drug effects. EN enzymology. GD ... Circoviridae - Preferred Concept UI. M0027337. Scope note. A family of very small viruses containing circular, single-stranded ...
Circoviridae, Flaviviridae, Herpesviridae, Paramyxoviridae, Parvoviridae, Pheuiviridae, and Rhabdoviridae viral families. ... a proxy for the putative natural route of infection) (27). This experimental H5N1 infection of foxes resulted in severe ... Naturally occurring influenza infection in a ferret (Mustela putorius furo) colony. J Vet Diagn Invest. 2009;21:527-30. DOI ... a common infection that causes severe illness and potentially increases susceptibility to other infections, although ...
... we identified 1,011 sequences corresponding to the capsid and Rep genes from the Circoviridae family. From a plasma sample ... bronchopulmonary infections, and parvovirus B19 and COVID-19 infections. In November 2021, 14 months after receiving pulsed ... Opriessnig T, Prickett JR, Madson DM, Shen HG, Juhan NM, Pogranichniy RR, et al. Porcine circovirus type 2 (PCV2)-infection and ... Central nervous system infections after solid organ transplantation. Curr Opin Infect Dis. 2021;34:207-16. DOIPubMedGoogle ...
Circoviridae Medicine & Life Sciences 100% * Central Nervous System Infections Medicine & Life Sciences 66% ... Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. In: mBio. ... Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. mBio. 2013; ... Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. / Tan, Le ...
Circoviridae, Flaviviridae, Herpesviridae, Paramyxoviridae, Parvoviridae, Pheuiviridae, and Rhabdoviridae viral families. ... a proxy for the putative natural route of infection) (27). This experimental H5N1 infection of foxes resulted in severe ... Naturally occurring influenza infection in a ferret (Mustela putorius furo) colony. J Vet Diagn Invest. 2009;21:527-30. DOI ... a common infection that causes severe illness and potentially increases susceptibility to other infections, although ...
... in a quantitative way the severe decrease of the cellular components of the bone marrow in presence of the infection for CAV, ... between one and twenty-one days post infection (PI), they were analyzed in magnifications of 200× and 400×. Histopathology ... 1979), a Gyrovirus, within the family Circoviridae [1]. The virus causes aplastic anaemia, generalized lymphoid atrophy and ... Engstrom BE, Luthman M: Blue wing disease of chickens: experimental infection with a Swedish isolate of chicken anaemia agent ...
Circoviridae infections - virology, swine. ... faeces and serum at some infection stages. The purpose of this ...
The virus belongs to the genus Circovirus, family Circoviridae. This viral agent exhibits a high rate of evolution and can be ... Several studies have shown that co-infections of pigs with PCV-2 and other viral pathogens, such as porcine parvovirus (PPV), ... PRV is the causative agent of the pseudorabies (PR) or Aujeszkys disease, an infection that leads to severe economic losses in ...
Specific viral infections 186741005 removed: 2019-01-31. *Viral agent as the cause of other diseases 186757005 removed: 2010-01 ... Disease due to Circoviridae 110271000. *Disease due to Coronaviridae 27619001. *Disease due to Filoviridae 198007 ... X]Other viral infections of unspecified site 187470009 removed: 2009-01-31 ...
Infecções por Circoviridae/diagnóstico , Infecções por Circoviridae/epidemiologia , Infecções por Circoviridae/veterinária , ... Nevertheless, co-infection had no effect on lung lesion scores. The presence of multiple MLVA types (mixed infections) ... Infecções por Circoviridae/diagnóstico , Infecções por Circoviridae/epidemiologia , Infecções por Circoviridae/veterinária , ... Infecções por Circoviridae , Circovirus , Miocardite , Doenças dos Suínos , Animais , Infecções por Circoviridae/veterinária , ...
Persistent infection with chicken anaemia virus and some effects of highly virulent infectious bursal disease virus infection ... Biagini P, Bendinelli M, Hino S, Kakkola L, Mankertz A, Niel C, Circoviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ ... which might represent a putative short-lived acute infection with possible subsequent re-infection or just declines of the HGyV ... Evidence of HGyV Infections. No samples from 50 healthy blood donors studied yielded positive results for HGyV (Table 1). Of 4 ...
Porcine circovirus type 2 (PCV2) from the Circoviridae family has recently been associated with two serious diseases of swine, ... The PCR results obtained from PCV2 specific oligonucleotide primers confirmed a PCV2 infection. In addition, archive samples ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
Rosario, K., Breitbart, M., and Harrach, B. (2017). Revisiting the taxonomy of the family Circoviridae: establishment of the ... Jørgensen, P. H., Otte, L., Nielsen, O. L., and Bisgaard, M. (1995). Influence of subclinical virus infections and other ... cell infection ability and virulence (Renshaw et al., 1996; Yamaguchi et al., 2001; Todd et al., 2002). VP2 is a scaffolding ...
MERS-CoV infection did not prevent the IFN-induced nuclear translocation of phosphorylated STAT1, in contrast to infection with ... Members of the family Circoviridae, specifically the genus Circovirus, were thought to infect only vertebrates; however, ... Human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infection. Infection is critically ... Thus, CatL and CatB are not required for HPV16 infection but instead appear to restrict infection. ...
... during which it can move from its original site of infection, in the skin, to neurons where it sets up a life-long infection. ... may represent a new viral genus of the Circoviridae family or possibly even a new viral family.. "8 ... Early in an infection, there usually arent a lot of pathogens present, and so there arent very many of these activated DC; ... As influenza infections go - not close to something like smallpox or ebola, but some 20 times higher than normal seasonal flu[↩ ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
Cross Infection C23.550.291.875.500 Cross-Priming G12.425.260 Crowns E6.323.428.100 E6.780.346.250 E6.323.528.250 E7.695.190.88 ... Circoviridae B4.909.204.120 Circovirus B4.909.204.120.150 Cistanche B1.650.940.800.575.100.788.500 B1.650.940.800.575.100. ... Tumor Virus Infections C4.619.935 C4.925 Tungrovirus B4.715.835 Tunica Intima A7.231.330.800 A10.272.491.355.800 Tunica Media ... Epstein-Barr Virus Infections C4.619.935.313 C4.925.313 Erbium D1.268.477.437 Erbovirus B4.909.777.618.290 Erectile Dysfunction ...
In my opinion, the immune systems of such birds can cope with the infection and either eliminate the viral infection completely ... PBFD virus is the smallest known virus capable of causing disease and is part of a new family of viruses known as circoviridae ... Secondary viral, fungal, bacterial, or parasitic infections are common as a consequence of a PBFD viral infections suppression ... are often caused by secondary infections and may not be directly connected to PBFD virus infections. ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... The smallest-the ssDNA circoviruses, family Circoviridae-code for only two proteins and have a genome size of only two ... Other coronaviruses are known to cause mild infections in humans,[168] so the virulence and rapid spread of SARS infections- ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ...
AcBlank, AcEGFP, AcBSEGFP, AcEGFP-HS4, and AcEGFP-HS4− infected the Sf9 cells at a multiplicity of infection (MOI) of 1. The ... Porcine circovirus type 2, a member of the Circoviridae family, is a small, icosahedral, non-enveloped, single-stranded ... All virus used for infection were at the second passage (P2). Virus titers were determined according to the end-point dilution ... Crisci E, Bárcena J, Montoya M (2012) Virus-like particles: the new frontier of vaccines for animal viral infections. Vet ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... The smallest viral genomes - the ssDNA circoviruses, family Circoviridae - code for only two proteins and have a genome size of ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ... Smallpox infections have been eradicated.[178] Vaccines are available to prevent over thirteen viral infections of humans,[179] ...
... and only limited serological evidence for infection in adjacent zones of Uganda and Kenya.114 The virus and its disease are ... GENERAL INTRODUCTION: CIRCOVIRIDAE AND ANELLOVIRIDAE. *Post-weaning multi-systemic wasting syndrome in swine ... most experimental studies have induced only mild or subclinical infection.90, 102 It is therefore possible that some early ...
Bats as a continuing source of emerging infections in humans. . Rev Med Virol. 17. : 67. -. 91. 17042030. 6. Tong. S. , Li. Y. ... Circoviridae. family, torque teno virus, including torque teno felis virus, torque teno sus virus 1 and torque teno canis virus ... This has been well exemplified by the highly fatal human infection due to avian influenza A H5N1 in 1997 [1]. . The outbreak of ... A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America. . PLoS One. 5. : e13381. ...
infection = PARVOVIRIDAE INFECTIONS. Allowable Qualifiers:. CH chemistry. CL classification. DE drug effects. EN enzymology. GD ... Circoviridae [B04.280.120] + Circoviridae + * DNA Tumor Viruses [B04.280.210] + DNA Tumor Viruses + ...
In comparison to nanovirids, members of the family Circoviridae possess closely related Rep proteins and morphologically ... but not all nanovirid infections. These additional DNAs, classified in alphasatellite species in different genera of the ...
Laboratory exposures may cause serious infection, but effective treatment and preventative measures are available and the risk ... Adenoviridae, Arenaviridae, Astroviridae, Baculoviridae, Birnaviridae, Bornaviridae, Bunyaviridae, Caliciviridae, Circoviridae ... dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening ... laboratory exposures may cause infections, but effective treatment and preventive measures are available, and the risk of ...
  • Background: Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Porcine Circovirus Type 2 (PCV2) andHepatitis E virus (HEV) are common and economically important viral disease causative agents detected in pig oralfluid (OF), faeces and serum at some infection stages. (uni-lj.si)
  • The virus belongs to the genus Circovirus, family Circoviridae. (wattagnet.com)
  • Porcine circovirus type 2 (PCV2) from the Circoviridae family has recently been associated with two serious diseases of swine, post-weaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). (irb.hr)
  • Porcine circovirus type 2, a member of the Circoviridae family, is a small, icosahedral, non-enveloped, single-stranded circovirus DNA virus (size ~17 nm) (Tischer et al. (springeropen.com)
  • The characteristics of its genome-a single, closed molecule of circular, negative-sense DNA ≈2,300 nt long-and sequence homology with the chicken anemia virus (CAV) have suggested that HGyV might be the first human-infecting member of the genus Gyrovirus , which is part of the family Circoviridae and encompasses only 1 previously known species, CAV ( 2 ). (cdc.gov)
  • may represent a new viral genus of the Circoviridae family or possibly even a new viral family. (iayork.com)
  • Several studies have shown that co-infections of pigs with PCV-2 and other viral pathogens, such as porcine parvovirus (PPV), pseudorabies virus (PRV) and swine torque teno sus viruses (TTSuVs), may enhance CVP2-associated lesions and increase the incidence of SDPD under both experimental and field conditions. (wattagnet.com)
  • The PBFD virus is the smallest known virus capable of causing disease and is part of a new family of viruses known as circoviridae. (somethingcheeky.com)
  • Some viruses, including those that cause HIV/AIDS , HPV infection , and viral hepatitis , evade these immune responses and result in chronic infections. (knowpia.com)
  • In my opinion, the immune systems of such birds can cope with the infection and either eliminate the viral infection completely or keep the infection at such low levels that the virus cannot be detected and the bird does not show any symptoms of the disease. (somethingcheeky.com)
  • Immune responses can also be produced by vaccines , which confer an artificially acquired immunity to the specific viral infection. (knowpia.com)
  • Cranioventral pulmonary consolidation and pleurisy in slaughter pigs are characteristic for infections with Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae, respectively, although other pathogens may cause similar lesions and/or be involved in their development. (bvsalud.org)
  • Solid organ transplant recipients are highly susceptible to infections that sometimes have uncommon clinical manifestations ( 1 - 3 ). (cdc.gov)
  • The virus causes aplastic anaemia, generalized lymphoid atrophy and increased mortality after infection of day-old susceptible chickens [ 2 ]. (biomedcentral.com)
  • Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. (elsevier.com)
  • IMPORTANCE Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology frequently remains unknown, which hampers development of therapeutic or preventive strategies. (elsevier.com)
  • CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. (elsevier.com)
  • Using such technology, we identified and characterized the full genome of a novel cyclovirus in cerebrospinal fluid (CSF) specimens from two Vietnamese patients with CNS infections of unknown etiology, which was subsequently detected in none of 122 CSF specimens from patients with noninfectious neurological disorders but 4% of 642 CSF specimens from Vietnamese patients with suspected or confirmed CNS infections. (elsevier.com)
  • Five swans had onset of highly pathogenic avian influenza virus infection while in captivity. (cdc.gov)
  • Human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infection. (microbiologyresearch.org)
  • Additional symptoms, such as high white cell counts, are often caused by secondary infections and may not be directly connected to PBFD virus infections. (somethingcheeky.com)
  • Viral infections in animals provoke an immune response that usually eliminates the infecting virus. (knowpia.com)
  • Similarly, although rinderpest virus (RPV) can infect sheep and goats in Africa, most experimental studies have induced only mild or subclinical infection. (anipedia.org)
  • This has been well exemplified by the highly fatal human infection due to avian influenza A H5N1 in 1997 [1] . (cdc.gov)
  • dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening disease that is frequently fatal, for which there are no vaccines or treatments, or a related agent with unknown risk of transmission. (absa.org)
  • Among transplant recipients, it is especially critical to detect infection, often viral, to prevent unnecessary interruption of treatment. (cdc.gov)
  • This technique demonstrates in a quantitative way the severe decrease of the cellular components of the bone marrow in presence of the infection for CAV, supporting with numeric data the histology image evaluated by the pathologist. (biomedcentral.com)
  • PRV is the causative agent of the pseudorabies (PR) or Aujeszky's disease, an infection that leads to severe economic losses in the swine industry worldwide. (wattagnet.com)
  • The infectious dose of norovirus required to produce infection in humans is fewer than 100 particles. (knowpia.com)
  • Timeline of the disease event, in which encephalitis and death in wild mammals at a rehabilitation center occurred after systemic infection with highly pathogenic avian influenza A subtype H5N8, United. (cdc.gov)
  • The PCR results obtained from PCV2 specific oligonucleotide primers confirmed a PCV2 infection. (irb.hr)
  • Infection is critically dependent on the RSV fusion (F) protein, which mediates fusion between the viral envelope and airway epithelial cells. (microbiologyresearch.org)
  • We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. (elsevier.com)
  • Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. (elsevier.com)