Sleep Disorders, Circadian Rhythm
Period Circadian Proteins
Circadian Rhythm Signaling Peptides and Proteins
ARNTL Transcription Factors
Jet Lag Syndrome
Nuclear Receptor Subfamily 1, Group D, Member 1
Antimicrobial Cationic Peptides
Vasoactive Intestinal Peptide
Casein Kinase Iepsilon
Amino Acid Sequence
Molecular Sequence Data
Natriuretic Peptide, Brain
Gene Expression Regulation
Seasonal Affective Disorder
Work Schedule Tolerance
Nuclear Receptor Subfamily 1, Group F, Member 1
Calcitonin Gene-Related Peptide
Dorsomedial Hypothalamic Nucleus
Photoreceptor Cells, Invertebrate
Basic Helix-Loop-Helix Transcription Factors
Ocular Physiological Phenomena
Peptide Nucleic Acids
Natriuretic Peptide, C-Type
Sequence Homology, Amino Acid
Chromatography, High Pressure Liquid
Protein Structure, Secondary
Casein Kinase Idelta
Receptors, Formyl Peptide
Atrial Natriuretic Factor
Intracellular Signaling Peptides and Proteins
Receptors, Vasoactive Intestinal Peptide, Type II
Protein Structure, Tertiary
Casein Kinase I
Animals, Genetically Modified
Receptors, Vasoactive Intestinal Peptide
Body Temperature Regulation
Cell Cycle Proteins
Dose-Response Relationship, Drug
Analysis of Variance
Gene Expression Regulation, Plant
Recombinant Fusion Proteins
Receptor, Melatonin, MT2
Protein Processing, Post-Translational
Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria. (1/177)The kai gene cluster, which is composed of three genes, kaiA, kaiB and kaiC, is essential for the generation of circadian rhythms in the unicellular cyanobacterium Synechococcus sp. strain PCC 7942. Here we demonstrate the direct association of KaiA, KaiB and KaiC in yeast cells using the two-hybrid system, in vitro and in cyanobacterial cells. KaiC enhanced KaiA-KaiB interaction in vitro and in yeast cells, suggesting that the three Kai proteins were able to form a heteromultimeric complex. We also found that a long period mutation kaiA1 dramatically enhanced KaiA-KaiB interaction in vitro. Thus, direct protein-protein association among the Kai proteins may be a critical process in the generation of circadian rhythms in cyanobacteria. (+info)
cpmA, a gene involved in an output pathway of the cyanobacterial circadian system. (2/177)We generated random mutations in Synechococcus sp. strain PCC 7942 to look for genes of output pathways in the cyanobacterial circadian system. A derivative of transposon Tn5 was introduced into the chromosomes of reporter strains in which cyanobacterial promoters drive the Vibrio harveyi luxAB genes and produce an oscillation of bioluminescence as a function of circadian gene expression. Among low-amplitude mutants, one mutant, tnp6, had an insertion in a 780-bp open reading frame. The tnp6 mutation produced an altered circadian phasing phenotype in the expression rhythms of psbAI::luxAB, psbAII::luxAB, and kaiA::luxAB but had no or little effect on those of psbAIII::luxAB, purF::luxAB, kaiB::luxAB, rpoD2::luxAB, ndhD::luxAB, and conII::luxAB. This suggests that the interrupted gene in tnp6, named cpmA (circadian phase modifier), is part of a circadian output pathway that regulates the expression rhythms of psbAI, psbAII, and kaiA. (+info)
Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria. (3/177)A negative feedback control of kaiC expression by KaiC protein has been proposed to generate a basic oscillation of the circadian clock in the cyanobacterium Synechococcus sp. PCC 7942. KaiC has two P loops or Walker's motif As, that are potential ATP-/GTP-binding motifs and DXXG motifs conserved in various GTP-binding proteins. Herein, we demonstrate that in vitro KaiC binds ATP and, with lower affinity, GTP. Point mutation by site-directed mutagenesis of P loop 1 completely nullified the circadian rhythm of kaiBC expression and markedly reduced ATP-binding activity. Moreover, KaiC can be autophosphorylated in vitro. These results suggest that the nucleotide-binding activity of KaiC plays important roles in the generation of circadian oscillation in cyanobacteria. (+info)
A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria. (4/177)Both regulated expression of the clock genes kaiA, kaiB, and kaiC and interactions among the Kai proteins are proposed to be important for circadian function in the cyanobacterium Synechococcus sp. strain PCC 7942. We have identified the histidine kinase SasA as a KaiC-interacting protein. SasA contains a KaiB-like sensory domain, which appears sufficient for interaction with KaiC. Disruption of the sasA gene lowered kaiBC expression and dramatically reduced amplitude of the kai expression rhythms while shortening the period. Accordingly, sasA disruption attenuated circadian expression patterns of all tested genes, some of which became arrhythmic. Continuous sasA overexpression eliminated circadian rhythms, whereas temporal overexpression changed the phase of kaiBC expression rhythm. Thus, SasA is a close associate of the cyanobacterial clock that is necessary to sustain robust circadian rhythms. (+info)
Circadian clock-protein expression in cyanobacteria: rhythms and phase setting. (5/177)The cyanobacterial gene cluster kaiABC encodes three essential circadian clock proteins: KaiA, KaiB and KaiC. The KaiB and KaiC protein levels are robustly rhythmical, whereas the KaiA protein abundance undergoes little if any circadian oscillation in constant light. The level of the KaiC protein is crucial for correct functioning of the clock because induction of the protein at phases when the protein level is normally low elicits phase resetting. Titration of the effects of the inducer upon phase resetting versus KaiC level shows a direct correlation between induction of the KaiC protein within the physiological range and significant phase shifting. The protein synthesis inhibitor chloramphenicol prevents the induction of KaiC and blocks phase shifting. When the metabolism is repressed by either translational inhibition or constant darkness, the rhythm of KaiC abundance persists; therefore, clock protein expression has a preferred status under a variety of conditions. These data indicate that rhythmic expression of KaiC appears to be a crucial component of clock precession in cyanobacteria. (+info)
Independence of circadian timing from cell division in cyanobacteria. (6/177)In the cyanobacterium Synechococcus elongatus, cell division is regulated by a circadian clock. Deletion of the circadian clock gene, kaiC, abolishes rhythms of gene expression and cell division timing. Overexpression of the ftsZ gene halted cell division but not growth, causing cells to grow as filaments without dividing. The nondividing filamentous cells still exhibited robust circadian rhythms of gene expression. This result indicates that the circadian timing system is independent of rhythmic cell division and, together with other results, suggests that the cyanobacterial circadian system is stable and well sustained under a wide range of intracellular conditions. (+info)
Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC. (7/177)kaiABC, a gene cluster, encodes KaiA, KaiB and KaiC proteins that are essential to circadian rhythms in the unicellular cyanobacterium Synechococcus sp. strain PCC 7942. Kai proteins can interact with each other in all possible combinations. This study identified two KaiA-binding domains (C(KABD1) and C(KABD2)) in KaiC at corresponding regions of its duplicated structure. Clock mutations on the two domains and kaiA altered the strength of C(KABD)-KaiA interactions assayed by the yeast two-hybrid system. Thus, interaction between KaiA and KaiC through C(KABD1) and C(KABD2) is likely important for circadian timing in the cyanobacterium. (+info)
Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from "Evolution Canyons" I and II, Israel. (8/177)Cyanobacteria are the only prokaryotes known thus far possessing regulation of physiological functions with approximate daily periodicity, or circadian rhythms, that are controlled by a cluster of three genes, kaiA, kaiB, and kaiC. Here we demonstrate considerably higher genetic polymorphism and extremely rapid evolution of the kaiABC gene family in a filamentous cyanobacterium, Nostoc linckia, permanently exposed to the acute natural environmental stress in the two microsite evolutionary models known as "Evolution Canyons," I (Mount Carmel) and II (Upper Galilee) in Israel. The family consists of five distinct subfamilies (kaiI-kaiV) comprising at least 20 functional genes and pseudogenes. The obtained data suggest that the duplications of kai genes have adaptive significance, and some of them are evolutionarily quite recent (approximately 80,000 years ago). The observed patterns of within- and between-subfamily polymorphisms indicate that positive diversifying, balancing, and purifying selections are the principal driving forces of the kai gene family's evolution. (+info)
Circadian rhythm is the internal biological clock that regulates the sleep-wake cycle. It is controlled by a small group of cells in the brain called the suprachiasmatic nucleus (SCN), which responds to light and dark signals from the environment to synchronize our bodily functions with the 24-hour day-night cycle.
Sleep disorders can be caused by disruptions to the body's natural circadian rhythm, such as shift work sleep disorder, jet lag, or exposure to artificial light at night. These disruptions can lead to difficulty falling asleep, staying asleep, or experiencing poor quality sleep, which can have negative effects on physical and mental health.
Treatment for sleep disorders often involves a combination of lifestyle changes, such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment. Medications or other therapies may also be prescribed to help regulate sleep patterns or manage symptoms.
In addition to disrupting circadian rhythm, sleep disorders can also have other causes, such as stress, anxiety, depression, or certain medical conditions like sleep apnea. It is important to seek medical advice if you are experiencing persistent sleep problems or difficulty functioning during the day due to poor sleep.
Chronobiology disorders can result when the body's natural circadian rhythm is disrupted or altered, leading to problems with sleep timing, duration, and quality, as well as other physiological and behavioral issues. Examples of chronobiology disorders include:
1. Circadian rhythm sleep disorders: These are conditions that affect the body's natural sleep-wake cycle, such as delayed sleep phase syndrome (DSPS) and advanced sleep phase disorder (ASPD).
2. Jet lag: This occurs when traveling across time zones, causing a mismatch between the body's internal clock and the local environment.
3. Shift work sleep disorder: This affects people who work outside of traditional daytime hours and experience difficulty adjusting to irregular sleep schedules.
4. Irregular sleep-wake patterns: This can be caused by factors such as working night shifts, rotating shifts, or having an irregular sleep schedule.
5. Sleep apnea: A sleep disorder in which a person's breathing is interrupted during sleep, often causing them to wake up frequently throughout the night.
6. Insomnia: Difficulty falling asleep or staying asleep, often caused by stress, anxiety, or other factors that disrupt the body's natural sleep-wake cycle.
7. Depression: A mood disorder that can affect the body's circadian rhythm, leading to changes in sleep patterns and other physiological functions.
8. Bipolar disorder: A mood disorder that can cause changes in sleep patterns, energy levels, and other physiological functions.
9. Seasonal affective disorder (SAD): A type of depression that occurs during the winter months when there is less sunlight.
10. Hypersomnia: Excessive sleepiness or prolonged periods of sleep, often caused by factors such as medication side effects, sleep disorders, or other medical conditions.
It's important to note that these are just a few examples of the many potential causes of irregular sleep patterns, and there may be other underlying factors that contribute to this symptom. If you are experiencing persistent changes in your sleep patterns, it is important to speak with a healthcare professional to determine the cause and find appropriate treatment.
Jet lag is also known as desynchronosis or traveler's exhaustion. It occurs when our body's natural sleep-wake cycle, regulated by an internal biological clock, is disrupted due to rapid travel across different time zones. The circadian rhythm, which controls the release of hormones and other physiological processes, takes time to adjust to the new time zone, leading to symptoms such as:
* Insomnia or excessive sleepiness
* Confusion and disorientation
* Digestive problems such as constipation or diarrhea
* Mood disturbances like irritability or depression
The severity of jet lag can vary depending on the number of time zones crossed, with longer flights causing more significant disruptions to our internal clock. Additionally, some people may be more sensitive to jet lag than others due to individual differences in sleep patterns and circadian rhythms.
There are several strategies that can help alleviate the symptoms of jet lag, such as:
* Gradually adjusting sleep schedules before traveling
* Avoiding caffeine and alcohol, which can disrupt sleep patterns further
* Exposure to sunlight or bright artificial light to help regulate our circadian rhythm
* Taking melatonin supplements to help reset our internal clock.
While jet lag is a temporary condition that usually resolves within a few days, it can have significant impacts on our daily activities and overall well-being during the adjustment period. Therefore, understanding the definition of jet lag syndrome and its causes is essential for managing this common travel-related disorder.
SAD is thought to be caused by the lack of sunlight during the winter months, which can disrupt the body's internal clock and affect the production of neurotransmitters such as serotonin and melatonin. This can lead to feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed.
Treatment for SAD may include light therapy, which involves exposure to bright artificial light that mimics natural sunlight, as well as other forms of therapy such as cognitive-behavioral therapy (CBT) and medication. Lifestyle changes such as regular exercise, social support, and improving sleep habits can also be helpful in managing symptoms of SAD.
The effects of sleep deprivation can be severe and long-lasting, including:
1. Impaired cognitive function: Sleep deprivation can affect attention, memory, and decision-making skills, making it more difficult to perform daily tasks and make sound judgments.
2. Emotional distress: Lack of sleep can lead to irritability, anxiety, and depression, which can negatively impact relationships and overall well-being.
3. Physical health problems: Chronic sleep deprivation has been linked to an increased risk of obesity, diabetes, cardiovascular disease, and immune system dysfunction.
4. Impaired motor function: Sleep deprivation can cause coordination problems, clumsiness, and a higher risk of accidents, particularly in activities that require attention and quick reflexes (e.g., driving).
5. Premature aging: Chronic sleep deprivation can accelerate the aging process and reduce the body's ability to repair and regenerate cells.
6. Reduced productivity and performance: Sleep deprivation can lead to decreased productivity, poor work quality, and increased absenteeism, which can negatively impact career advancement and financial stability.
7. Increased risk of accidents and injuries: Drowsy driving and workplace accidents are common consequences of sleep deprivation, which can result in fatalities and long-term disabilities.
8. Weakened immune system: Sleep deprivation can weaken the immune system, making it more difficult to fight off infections and diseases.
9. Negative impact on relationships: Sleep deprivation can lead to mood swings, irritability, and difficulty interacting with others, which can strain personal and professional relationships.
10. Increased risk of mental health disorders: Chronic sleep deprivation has been linked to an increased risk of developing anxiety, depression, and other mental health disorders.
To avoid these negative consequences, it's essential to prioritize sleep and make it a critical component of your daily routine. Establishing a consistent sleep schedule, creating a sleep-conducive environment, and practicing relaxation techniques can help improve sleep quality and duration. Additionally, avoiding stimulating activities before bedtime, limiting exposure to electronic screens, and seeking professional help if sleep problems persist can contribute to better overall health and well-being.
People with dyssomnia may experience symptoms such as:
* Difficulty falling asleep
* Waking frequently during the night
* Waking too early in the morning
* Feeling groggy or disoriented upon waking
* Poor quality sleep
Dyssomnia can be caused by a variety of factors, including stress, anxiety, depression, chronic pain, sleep disorders, and certain medications. Treatment options for dyssomnia may include lifestyle changes, such as establishing a regular sleep schedule and avoiding caffeine and alcohol before bedtime, as well as cognitive behavioral therapy, relaxation techniques, and in some cases, medication.
It is important to note that dyssomnia is not a specific sleep disorder, but rather a term used to describe a group of related conditions. If you are experiencing difficulty sleeping or poor quality sleep, it is important to speak with a healthcare professional for proper diagnosis and treatment.
There are several risk factors for developing AF, including:
1. Age: The risk of developing AF increases with age, with the majority of cases occurring in people over the age of 65.
2. Hypertension (high blood pressure): High blood pressure can damage the heart and increase the risk of developing AF.
3. Heart disease: People with heart disease, such as coronary artery disease or heart failure, are at higher risk of developing AF.
4. Diabetes mellitus: Diabetes can increase the risk of developing AF.
5. Sleep apnea: Sleep apnea can increase the risk of developing AF.
6. Certain medications: Certain medications, such as thyroid medications and asthma medications, can increase the risk of developing AF.
7. Alcohol consumption: Excessive alcohol consumption has been linked to an increased risk of developing AF.
8. Smoking: Smoking is a risk factor for many cardiovascular conditions, including AF.
9. Obesity: Obesity is a risk factor for many cardiovascular conditions, including AF.
Symptoms of AF can include:
1. Palpitations (rapid or irregular heartbeat)
2. Shortness of breath
4. Dizziness or lightheadedness
5. Chest pain or discomfort
AF can be diagnosed with the help of several tests, including:
1. Electrocardiogram (ECG): This is a non-invasive test that measures the electrical activity of the heart.
2. Holter monitor: This is a portable device that records the heart's rhythm over a 24-hour period.
3. Event monitor: This is a portable device that records the heart's rhythm over a longer period of time, usually 1-2 weeks.
4. Echocardiogram: This is an imaging test that uses sound waves to create pictures of the heart.
5. Cardiac MRI: This is an imaging test that uses magnetic fields and radio waves to create detailed pictures of the heart.
Treatment for AF depends on the underlying cause and may include medications, such as:
1. Beta blockers: These medications slow the heart rate and reduce the force of the heart's contractions.
2. Antiarrhythmics: These medications help regulate the heart's rhythm.
3. Blood thinners: These medications prevent blood clots from forming and can help reduce the risk of stroke.
4. Calcium channel blockers: These medications slow the entry of calcium into the heart muscle cells, which can help slow the heart rate and reduce the force of the heart's contractions.
In some cases, catheter ablation may be recommended to destroy the abnormal electrical pathway causing AF. This is a minimally invasive procedure that involves inserting a catheter through a vein in the leg and guiding it to the heart using x-ray imaging. Once the catheter is in place, energy is applied to the abnormal electrical pathway to destroy it and restore a normal heart rhythm.
It's important to note that AF can increase the risk of stroke, so anticoagulation therapy may be recommended to reduce this risk. This can include medications such as warfarin or aspirin, or in some cases, implantable devices such as a left atrial appendage closure device.
In conclusion, atrial fibrillation is a common heart rhythm disorder that can increase the risk of stroke and heart failure. Treatment options depend on the underlying cause and may include medications, cardioversion, catheter ablation, or anticoagulation therapy. It's important to work closely with a healthcare provider to determine the best course of treatment for AF.
1. Insomnia: difficulty falling asleep or staying asleep
2. Sleep apnea: pauses in breathing during sleep
3. Narcolepsy: excessive daytime sleepiness and sudden attacks of sleep
4. Restless leg syndrome: uncomfortable sensations in the legs during sleep
5. Periodic limb movement disorder: involuntary movements of the legs or arms during sleep
6. Sleepwalking: walking or performing other activities during sleep
7. Sleep terrors: intense fear or anxiety during sleep
8. Sleep paralysis: temporary inability to move or speak during sleep
9. REM sleep behavior disorder: acting out dreams during sleep
10. Circadian rhythm disorders: disruptions to the body's internal clock, leading to irregular sleep patterns.
Sleep disorders can be caused by a variety of factors, such as stress, anxiety, certain medications, sleep deprivation, and underlying medical conditions like chronic pain or sleep apnea. Treatment for sleep disorders may include lifestyle changes (such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment), medications, and behavioral therapies (such as cognitive-behavioral therapy for insomnia). In some cases, surgery or other medical interventions may be necessary.
It is important to seek medical attention if you suspect that you or someone you know may have a sleep disorder, as untreated sleep disorders can lead to serious health problems, such as cardiovascular disease, obesity, and depression. A healthcare professional can help diagnose the specific sleep disorder and develop an appropriate treatment plan.
Paul H. Taghert
Pigment dispersing factor
Vasoactive intestinal peptide
Euthyroid sick syndrome
Central melanocortin system
Death regulator Nedd2-like caspase
Vasopressin receptor 1A
Index of biology articles
Glossary of medicine
DeCS 2010 - Novos termos
Animal Hormones Analysis Service - Creative Proteomics
IJMS | Free Full-Text | Brain RNA-Seq Profiling of the Mucopolysaccharidosis Type II Mouse Model
Is bile the key that turns on the gut clock? - Hack your gut
Pesquisa | Portal Regional da BVS
Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity | Scientific Reports
DeCS 2010 - Novos termos
DeCS 2010 - Novos termos
DeCS 2010 - Novos termos
Protein Precursors | Profiles RNS
Seminars - Texas A&M Biology
Student Publications - University of Mississippi Medical Center
China good quality [#g1#] on sales
Corticotrophs. Medical search
Seer Platform Shows Promise in Plasma Proteogenomics Study | GenomeWeb
Mechanisms Of Hormone Actions
View source - 2010.igem.org
PLOS Genetics, Public Library of Science | IDEAS/RePEc
July | 2021 | Chk signal
Saliva proteomics updates in biomedicine | Journal of Biological Research-Thessaloniki | Full Text
Bone Markers in Osteoporosis: Bone Turnover Markers, Bone Formation Markers, Bone Resorption Markers
Publications - Salk Institute for Biological Studies
CDC Science Clips
What's hot today: Current papers in developmental biology and gene function
Multiple Choice Questions MCQ
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism | Genome Integrity | Full Text
- Animal Hormones is a type of signaling molecules, which is produced by glands in multicellular organisms. (creative-proteomics.com)
- Hormones are also involved in the wake-sleep cycle and other circadian rhythms. (creative-proteomics.com)
- Colonic muscle contractility is also influenced by gut microflora profile, an array of neuropeptides, several peripheral peptides and select hormones, and the rate of food consumption. (ift.org)
- These hormones and proteins alter genetic expression in target tissues which adjusts our physiology to the environment. (hackyourgut.com)
- Over the years her laboratory made important contributions to the current knowledge on the regulation and the relative roles of corticotropin releasing hormone (CRH) and vasopressin on the HPA axis, and characterization of the properties, signaling-transduction and regulation of the receptors and actions for these peptide hormones. (nih.gov)
- It means that hormones are cell signaling molecules. (prepladder.com)
- These hormones are synthesized from a rough endoplasmic reticulum (RER) as a long peptide called pre-pro-hormones. (prepladder.com)
- Multi-disciplinary, multiple-investigator teams proposing mechanistic clinical studies to elucidate the relationship of circadian rhythm to causal pathways of disease are encouraged. (nih.gov)
- The central clock in the brain uses specific biochemical and neural pathways to pass its circadian signals along to other organs, such as the liver or heart. (nih.gov)
- Recent studies have also revealed that circadian system affects metabolic homeostasis while metabolic pathways feed back into the regulation of circadian system and modulate many physiological processes and behavior. (nih.gov)
- We do not yet know the discrete targets, in brain, of the NCS-Rapgef2/ERK-, PKA/CREB- and Epac/p38-specific cAMP signaling pathways elucidated in cellula . (nih.gov)
- The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. (peptide-powder.com)
- Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. (salk.edu)
- Our molecular clock and circadian rhythm is affected by clock genes and their transcription factors. (ift.org)
- 2009). The rhythmic impact of clock genes, Per1 and Per2, affect circadian activity in the hypothalamus and in peripheral tissues. (ift.org)
- It appears that some circadian clock genes, such as Foxa2 , are not only regulated differently under feeding and fasting conditions, but that there is tissue specificity, such as lipid and protein metabolism in heart and liver, at least in mice (Wolfrum, C. et al. (ift.org)
- Roughly 170 of these genes representing common characteristics of slightly more than 11,000 time-related metabolic traits had an overlap with several categories, such as wound healing, inflammation, protein kinase cascade, and regulation of signal transduction. (ift.org)
- Ninety nine percent of PfNF-YB binding was to putative promoter regions of protein coding genes of which only 16% comprise proteins of known function. (oncotarget.com)
- PfNF-YB binds to genes coding for proteins implicated in a range of different biological functions, such as replication protein A large subunit (DNA replication), hypoxanthine phosphoribosyltransferase (nucleic acid metabolism) and multidrug resistance protein 2 (intracellular transport). (oncotarget.com)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. (nih.gov)
- 19. RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. (nih.gov)
- Her most recent work demonstrating that activation of CRH transcription requires the CREB coactivator, Transducer of Regulated CREB activity (TORC), regulated by the protein kinase, salt inducible kinase (SIK), uncovered a missing link in current knowledge of the regulation of CRH transcription. (nih.gov)
- Using cell cytometry (FACS) and fluorimetry, we demonstrated in yeast the successful expression and translational regulation of a fusion of mRNA binding protein and fluorescent protein. (igem.org)
- Apelin is a bioactive peptide recently identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ. (lookformedical.com)
- Targeted mutations in either the intracellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can lead to desynchronization of SCN neuronal clocks and loss of behavioral rhythms. (ljmu.ac.uk)
- This FOA invites applications for clinical research to elucidate circadian-dependent mechanisms contributing to the pathophysiology of human obesity, diabetes-related metabolism, obesity-coupled risks for heart, lung, and blood disease, and the identification of novel therapies to improve circadian rhythm for primary or secondary prevention of obesity-associated disease risks. (nih.gov)
- Intervention studies to identify circadian-mediated mechanisms of obesity, diabetes-related metabolism, and obesity-coupled heart, lung, and blood pathophysiology may be proposed. (nih.gov)
- Behavioral, physiological, pharmacological, molecular, and genomic studies aimed at elucidating the relationship between circadian-dependent mechanisms and disease are appropriate. (nih.gov)
- 3. Resveratrol Maintains Lipid Metabolism Homeostasis via One of the Mechanisms Associated with the Key Circadian Regulator Bmal1. (nih.gov)
- 5. Capsaicin Ameliorates the Redox Imbalance and Glucose Metabolism Disorder in an Insulin-Resistance Model via Circadian Clock-Related Mechanisms. (nih.gov)
- 12. Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. (nih.gov)
- The objective of this FOA is to understand the molecular mechanisms of alcohol-induced tissue damage that involve central and peripheral circadian rhythms, particularly their connection with metabolism and metabolic disorders. (nih.gov)
- In the past two decades, major progress has been made to understand the molecular mechanisms of circadian rhythms. (nih.gov)
- Tv1 and Tsu1.1 are distinct from previously identified venom peptides, expanding the toolkit of peptides that can potentially be used to investigate the physiological mechanisms of pain and diet. (nature.com)
- In addition, research addressing the mechanisms of pulsatility of glucocorticoid secretion recently demonstrated that each ACTH-induced secretory pulse is associated with induction of steroidogenic proteins transcription. (nih.gov)
- Third, it demonstrates that fold switchers can regulate biological processes by discussing two proteins, RfaH and KaiB, whose dramatic secondary structure remodeling events directly affect gene expression and a circadian clock, respectively. (nih.gov)
- A broad category of proteins that regulate the CIRCADIAN RHYTHM of an organism. (nih.gov)
- The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. (antibodypedia.com)
- I'm not going to jump down the 3000 word blog rabbit hole and go all comprehensive on the way circadian rhythms regulate gut health because I already did that here . (hackyourgut.com)
- The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically control cellular coupling. (ljmu.ac.uk)
- This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. (antibodypedia.com)
- The Gs-coupled GPCR PAC1, the receptor for the neuropeptide PACAP, in the retinohypothalamic projection to the suprachiasmatic nucleus required for environmental re-setting of circadian rhythm through photosensitive retinal ganglion cell activation (see e.g. (nih.gov)
- Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. (nih.gov)
- Maren Laughlin, Ph.D. Energy balance, thermogenesis and mitochondria biology, whole body intermediary carbohydrate, lipid and protein metabolism, and functional and metabolic imaging in adipose, pancreas and other metabolic organs. (nih.gov)
- 1. Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes. (nih.gov)
- This Funding Opportunity Announcement (FOA) encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol-induced organ damage. (nih.gov)
- NMN also enhances hepatic sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. (peptide-powder.com)
- As you can probably guess, organs doing random things at randoms times is very bad, especially organs that are dependent on properly timed signals from other organs. (hackyourgut.com)
- In the endocrine type of cell signaling, the chemical substances produced by the gland enter the bloodstream through fenestrated capillaries in the body and travels further to reach various target organs or cells that act as receptors. (prepladder.com)
- Calcitonin gene-related peptide (CGRP) is a key peptide in the afferent nociceptive pathway from the parabrachial area and mediates excitatory drive of CeA neurons. (iasp-pain.org)
- Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. (salk.edu)
- The flow rate and composition of saliva are effectively regulated by the autonomous nervous system, and are dependent on signalling by neuropeptides and intracellular calcium [ 12 ]. (biomedcentral.com)
- In the juxtacrine type of cell signaling, the cells that produce the chemical substance and the cells on which their receptors are present are in such close contact that the lie end expressed by the secretory cell and the receptor cell interact directly with each other. (prepladder.com)
- The opioid system of mu, delta and kappa receptors (MOR, DOR, KOR) and their peptide ligands (β-endorphin, enkephalin, dynorphin) have complex and partially opposing effects on amygdala function. (iasp-pain.org)
- The control of food intake is also an example of ultradian rhythm since the interval between two meals is less than 24hr. (prepladder.com)
- Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. (ljmu.ac.uk)
- The circadian rhythm system orchestrates the temporal organization of many aspects of physiology. (nih.gov)
- Circadian rhythms adjust our physiology so that we are more successful at adapting to our environment. (hackyourgut.com)
- They are further influenced by a number of factors such as age, circadian rhythm, psychological factors such as pain and stress, and any factors such as some medication and diseases (oral and systemic) affecting the physiology of the salivary glands [ 6 ]. (biomedcentral.com)
- 8. Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer's Disease Model. (nih.gov)
- Our long-term goal is to examine the parcellation of cAMP signaling during neurotransmission in the brain, at the genetic, cellular, morphological, and biochemical levels, and their penetrance to experience-driven behavior in the mouse. (nih.gov)
- Emerging research suggests that the extent of these processes and involvement of the genetic network, and the normal mammalian circadian rhythm controlled by the suprachiasmatic nucleus of the anterior hypothalamus, depend on our fed and fasting state and the kinds of foods consumed. (ift.org)
- Protein quantitative trait loci are links between genetic variants and plasma protein levels. (genomeweb.com)
- The hope is that pQTLs can help researchers map the connections between genetic variation and protein expression changes and, ultimately, disease. (genomeweb.com)
- From that data, they identified 184 protein-altering genetic variants that corresponded significantly with mass spec measurements of the matching variant peptide, associations that they termed mass spec protein altering variants, or MS-PAVs. (genomeweb.com)
- Team Aberdeen_Scotland:]] The AyeSwitch: a translationally regulated genetic toggle switch in yeast=== A novel genetic toggle switch regulated at the translational level was engineered in yeast that allowed the mutually exclusive expression of either green or cyan fluorescent protein. (igem.org)
- Genetic interaction study shows that Drice mediates its action by regulating Rho1GTPase functionally, and localization of polarity protein Disc large . (sdbonline.org)
- Included here are proteins that transmit intracellular and intercellular signals in a chronological manner along with proteins that sense light and time-dependent changes in the environment such as the PHOTOPERIOD . (nih.gov)
- Here we show that extended exposure to constant light promotes synchrony among SCN clock cells and the expression of ~24 h rhythms in behavior in mice in which intercellular signaling is disrupted through loss of VIP-VPAC2 signaling. (ljmu.ac.uk)
- To fully explore the complexity and function of the synapse proteome, and be able to analyze changes on a localized level in various cellular and subcellular compartments within the brain, it is essential to establish a comprehensive, highly characterized and standardized collection of specific monoclonal antibodies directed against all individual synapse proteins under native conditions. (nih.gov)
- While monoclonal antibodies offer a higher degree of specificity than polyclonal antibodies since each typically binds to one specific epitope within a target antigen, many commercially available antibodies exhibit cross-reactivity to non-related proteins, with one study indicating 75% of commonly used monoclonal antibodies (mAbs) show cross reactivity with other protein. (nih.gov)
- There is a pressing need for a systematic, cost effective, and scalable approach to identify physiological effects of venom peptides. (nature.com)
- Using this approach, we characterized the physiological and behavioral phenotypes of two peptides from the venom of predatory terebrid marine snails, teretoxins Tv1 from Terebra variegata and Tsu1.1 from Terebra subulata . (nature.com)
- Multidisciplinary, multiple investigator teams are strongly encouraged to realize the full potential for synergy between experts in heart, lung, blood, and metabolic disorders with circadian and sleep researchers. (nih.gov)
- The G-protein biased kappa opioid agonists, triazole 1.1 and nalfurafine, produce non-uniform behavioral effects in male rhesus monkeys. (umc.edu)
- We tested whether social signal processing in more traditional, head-restrained contexts is representative of the putative natural analog-social communication-by comparing responses to vocalizations within individual neurons in marmoset prefrontal cortex (PFC) across a series of behavioral contexts ranging from traditional to naturalistic. (salk.edu)
- These results suggest that neural representations of social signals in primate PFC are not static but highly flexible and likely reflect how nuances of the dynamic behavioral contexts affect the perception of these signals and what they communicate. (salk.edu)
- The acute phase proteins are nonspecific biochemical markers produced by hepatocytes in response to tissue injury, infection, or inflammation. (your-doctor.net)
- The best-characterized DAMP in the context of the injuryassociated inflammatory response is high-mobility group protein Bl (HMGBl), which is rapidly released into the circulation within 30 minutes following trauma. (your-doctor.net)
- To assess the synchronicity between respiratory-related neurons and the breath-by-breath variability of respiratory neuronal activity from optical signals, we developed a novel method by which we are able to analyze respiratory-related optical signals without cycle-triggered averaging. (pparsignaling.com)
- Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors. (iasp-pain.org)
- Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. (iasp-pain.org)
- Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). (lookformedical.com)
- 18. β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. (nih.gov)
- With regard to digestion, circadian rhythms help prepare the gut for food by preparing an anticipatory secretion of gastric acid and digestive enzymes right before we eat. (hackyourgut.com)
- Many proteins exist in multiple forms, exhibiting alterations like amino acid variants or truncations or post-translational modifications, which can impact their function. (genomeweb.com)
- Interestingly, Drosophila Malpighian tubules (MTs) express apoptotic proteins, without succumbing to cell death. (sdbonline.org)
- The circadian system comprises of a complex feedback network that involves interactions between the central nervous system and peripheral tissues. (nih.gov)
- This reflects, in part, a transient hemodynamic shift from peripheral circulation to tissues involved in digestive processes and the release of "satisfaction" peptides and carbohydrates that affect brain function. (ift.org)
- Despite the impact of these biological processes in circadian rhythm and possible effect on circadian control, the clock gene did not seem to be diurnally regulated in peripheral tissues. (ift.org)
- Proteomics use high throughput and high efficiency approaches with the support of bioinformatic tools in order to identify and quantify the total protein content of cells, tissues or biological fluids. (biomedcentral.com)
- Whereas several previous reviews have focused on various structural, physical-chemical, and evolutionary aspects of this newly emerging class of proteins, this minireview focuses on how fold switching modulates protein function and regulates biological processes. (nih.gov)
- The human oral microbiome is one of the most diverse of the human body and constitutes a dynamic entity that contributes more than 2000 microbial proteins from more than fifty bacterial genera to the saliva proteome [ 15 ]. (biomedcentral.com)
- And thus, electric light as both an effector and an enabler of additional activities or behaviors (e.g., shift work), may lead to circadian disruption. (nih.gov)
Identify and quantify1
- Given this, nanoparticles can serve as an enrichment tool, allowing researchers to pull proteins out of a sample, which they can then identify and quantify using technologies like mass spec. (genomeweb.com)
- Accordingly, protein levels (ARNTL, REV-ERBα, NFIL3) and genomic binding (ARNTL) of select regulators were reduced and arrhythmic following treatment. (nih.gov)
- Venom-peptide research and drug discovery has increased exponentially with the advance of genomic-transcriptomic sequencing and proteomic mass-spectrometry 10 . (nature.com)
- Such experiments have become more feasible in recent years as the development of affinity-based platforms - primarily from Olink and SomaLogic - have allowed researchers to measure thousands of proteins in parallel in plasma samples from tens of thousands of individuals, bringing the depth and throughput of proteomic studies to a level where they can be meaningfully integrated with genomic datasets. (genomeweb.com)
- 11. Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance. (nih.gov)
- D-cell mediated paracrine signaling is also present at the level of islet cells of the pancreas. (prepladder.com)
- Parcellated cyclic AMP signaling is likely to be functionally critical at neuropeptidergic, and catecholamine-modulated as well as glutamate-driven synapses in the brain. (nih.gov)
- Gierasch's research focuses on protein folding and protein-peptide interactions. (nih.gov)
- The self-association property of Nab3 adds to the previously documented interactions between these hnRNP-like proteins, RNA polymerase II, and the nascent transcript, Selleck Entinostat leading to a network of nucleoprotein interactions that define a higher order Nrd1-Nab3 complex. (chk-signal.com)
- A cis pQTL in many cases reflects the influence on a protein of the gene that codes for it, while trans pQTLs may reflect other phenomena, such as changes to other proteins that interact with the target protein or are in a signaling pathway with it. (genomeweb.com)
- These findings describe the first functional bioactivity of terebrid venom peptides in relation to pain and diet and indicate that Tv1 and Tsu1.1 may, respectively, act as antinociceptive and orexigenic agents. (nature.com)
- 7. Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling. (nih.gov)
- 13. Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes. (nih.gov)
- The master clock also holds some control over the peripheral clocks, but the peripheral clocks beat to their own rhythm even in the absence of light signals to the master clock. (hackyourgut.com)
- 9. Casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorates high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling. (nih.gov)
- A response to these social signals when subjects were head-restrained was not predictive of a comparable neural response to the identical vocalizations during natural communication. (salk.edu)
- NEW YORK - A team led by researchers at Weill Cornell Medicine-Qatar has used Seer's Proteograph proteomics platform for mapping protein quantitative trait loci (pQTLs) in a cohort of 325 individuals. (genomeweb.com)
- In their recent preprint, the researchers used the Proteograph system to identify more than 18,000 peptides from roughly 3,000 proteins across the 325 plasma samples they analyzed, providing a depth of coverage comparable to that of previous affinity-based efforts. (genomeweb.com)
- Agency for Research on Cancer (IARC) Working Group conclusion that "shift work that involves circadian disruption" is probably carcinogenic to humans (Group 2A) (IARC 2010). (nih.gov)
- A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. (antibodypedia.com)
- Objective: C-reactive protein (CRP) is a marker of cardiovascular disease. (pparsignaling.com)
- In this type of cell signaling, the chemical substances act on secretory cells themselves. (prepladder.com)
- In the paracrine type of cell signaling, the chemical substances a secretory cell produces reach the adjacent target cell, where the receptor is present, with the help of diffusion. (prepladder.com)
- The number of newly discovered peptides from the transcriptomes and proteomes of animal venom arsenals is rapidly increasing, resulting in an abundance of uncharacterized peptides. (nature.com)
- PACAPergic synapses mediating stress-dependent relapse to cocaine preference in rodents are also being investigated, in the context of parcellated cAMP signaling in both the PACAP- and dopamine-dependent components of this translationally important behavior. (nih.gov)
- The rationale for this recommendation was that electric light acts as both an effector (based on direct effects on circadian disruption and melatonin suppression, and animal models and human studies of light pollution and indoor light), and as an enabler, allowing what were once daytime activities to be conducted 24/7. (nih.gov)
- Mass spec-based proteomics, on the other hand, is better equipped to account for different proteoforms as it can detect features like variant peptides and post-translational modifications. (genomeweb.com)
- Protein Precursors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)