The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.
An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
A broad category of proteins that regulate the CIRCADIAN RHYTHM of an organism. Included here are proteins that transmit intracellular and intercellular signals in a chronological manner along with proteins that sense light and time-dependent changes in the environment such as the PHOTOPERIOD.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.
Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
Disruptions of the rhythmic cycle of bodily functions or activities.
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
Bouts of physical irritability or movement alternating with periods of quiescence. It includes biochemical activity and hormonal activity which may be cellular. These cycles are shorter than 24 hours and include sleep-wakefulness cycles and the periodic activation of the digestive system.
A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
The absence of light.
Flavoproteins that function as circadian rhythm signaling proteins in ANIMALS and as blue-light photoreceptors in PLANTS. They are structurally-related to DNA PHOTOLYASES and it is believed that both classes of proteins may have originated from an earlier protein that played a role in protecting primitive organisms from the cyclical exposure to UV LIGHT.
The measure of the level of heat of a human or animal.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).
The physical activity of a human or an animal as a behavioral phenomenon.
A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.
Treatment of disease by exposure to light, especially by variously concentrated light rays or specific wavelengths.
A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN RHYTHM.
The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
The illumination of an environment and the arrangement of lights to achieve an effect or optimal visibility. Its application is in domestic or in public settings and in medical and non-medical environments.
Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
An acetyltransferase with specificity towards the amine group of aromatic alkylamines (arylalkylamines) such as SEROTONIN. This enzyme is also referred to as serotonin acetylase despite the fact that serotonin acetylation can also occur through the action of broad specificity acetyltransferases such as ARYLAMINE N-ACETYLTRANSFERASE.
Elements of limited time intervals, contributing to particular results or situations.
The adaptation of drug administration to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.
The observable response an animal makes to any situation.
A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.
A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.
A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.
Photosensitive proteins expressed in the ROD PHOTORECEPTOR CELLS. They are the protein components of rod photoreceptor pigments such as RHODOPSIN.
Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts.
A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The measurement of frequency or oscillation changes.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
The conversion of absorbed light energy into molecular signals.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
An aggregation of cells in the middle hypothalamus dorsal to the ventromedial nucleus and bordering the THIRD VENTRICLE.
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A form-genus of spherical to rod-shaped CYANOBACTERIA in the order Chroococcales. They contain THYLAKOIDS and are found in a wide range of habitats.
Specialized cells in the invertebrates that detect and transduce light. They are predominantly rhabdomeric with an array of photosensitive microvilli. Illumination depolarizes invertebrate photoreceptors by stimulating Na+ influx across the plasma membrane.
A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Processes and properties of the EYE as a whole or of any of its parts.
A broad category of sleep disorders characterized by either hypersomnolence or insomnia. The three major subcategories include intrinsic (i.e., arising from within the body) (SLEEP DISORDERS, INTRINSIC), extrinsic (secondary to environmental conditions or various pathologic conditions), and disturbances of circadian rhythm. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Removal of an autonomic or sensory ganglion by any means.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions including vesicular transport, CHROMOSOME SEGREGATION; CYTOKINESIS, developmental processes, and the CIRCADIAN RHYTHM.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.
The consumption of edible substances.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.
Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.
A genus of hamsters characterized by small size, very short tail, and short, broad feet with hairy soles.
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
The processes of heating and cooling that an organism uses to control its temperature.
Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.
A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.
Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Any type of variation in the appearance of energy output of the sun. (NASA Thesaurus, 1994)
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
That branch of medicine dealing with the studies and effects of flight through the atmosphere or in space upon the human body and with the prevention or cure of physiological or psychological malfunctions arising from these effects. (from NASA Thesaurus)
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)
A genus of ascomycetous fungi, family Sordariaceae, order SORDARIALES, comprising bread molds. They are capable of converting tryptophan to nicotinic acid and are used extensively in genetic and enzyme research. (Dorland, 27th ed)
A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Inorganic compounds that contain lithium as an integral part of the molecule.
Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.

Effects of dispersed recreational activities on the microbiological quality of forest surface water. (1/9125)

The microbiological quality of forest surface waters in the Greenwater River watershed was examined to investigate the influence of heavy motorized camping in an area with no sanitary facilities. Indicator densities increased during weekend human-use periods when compared to weekdays. Increases in indicator densities were also noted downstream from heavily used camping areas when compared to upstream sites. Seasonal, weekly, and diurnal fluctuations in indicator densities were observed. This study suggests that potential health hazards exist in this watershed during periods of human use.  (+info)

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (2/9125)

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.  (+info)

Alteration of circadian time structure of blood pressure caused by night shift schedule. (3/9125)

The effects of night shift schedules on circadian time structure of blood pressure were studied in seven healthy young subjects by continuous monitoring of blood pressure every 30 min for 72 h. In the control experiment, subjects were instructed to sleep at regular times with the light off at 00.00 h and the light on at 07.00 h. In the shift experiment, they were instructed to go to bed at 06.00 h and wake up at 11.00 h. The circadian rhythm of blood pressure rapidly phase delayed by 3.5 h in the second night shift day as a group phenomenon. Individual differences in changes in power spectral patterns of blood pressure were found in the night shift schedule. Ultradian rhythmicity of blood pressure was more pronounced in three subjects, whereas the circadian rhythmicity was maintained in four subjects. These findings held when the adaptation to shift work was taken into account.  (+info)

Circadian variation in the expression of cell-cycle proteins in human oral epithelium. (4/9125)

At the tissue level, there is experimental and clinical data to suggest a cytokinetic coordination of the cell cycle with a greater proportion of cycling cells entering S-phase and mitosis at specific times of the day. The association of certain cell-cycle proteins with defined events in the cell cycle is well established and may be used to study the timing of cell-cycle phases over 24 hours. In this study oral mucosal biopsies were obtained from six normal human volunteers at 4-hour intervals, six times over 24 hours. Using immunohistochemistry, the number of positive cells expressing the proteins p53, cyclin-E, cyclin-A, cyclin-B1, and Ki-67 was determined for each biopsy and expressed as the number of positive cells per mm of basement membrane. We found a statistically significant circadian variation in the nuclear expression of all of these proteins with the high point of expression for p53 at 10:56 hours, cyclin-E at 14:59 hours, cyclin-A at 16:09 hours, cyclin-B1 at 21:13 hours, and Ki-67 at 02:50 hours. The circadian variation in the nuclear expression of cyclins-E (G1/S phase), -A (G2-phase), and -B1 (M-phase) with a normal physiological progression over time suggests a statistically significant circadian variation in oral epithelial cell proliferation. The finding of a circadian variation in the nuclear expression of p53 protein corresponding to late G1 is novel. This information has clinical implications regarding the timing of chemotherapy and radiotherapy.  (+info)

The biological clock of very premature primate infants is responsive to light. (5/9125)

Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light.  (+info)

Effects of different light intensities during the daytime on circadian rhythm of core temperature in humans. (6/9125)

The present study was to determine the effects of bright light exposure during the daytime on core temperature rhythm. Eight female students participated as subjects. They were exposed to bright light of 5000 lux or dim light of 200 lux for 13 hours (06:30-19:30) for two consecutive days. Except the sleep period (22:30-06:30) and during the bright light exposure, light intensity was controlled at 200 lux. Rectal temperature data were collected every 10 min throughout the whole experimental period. The mean level of rectal temperature was not significantly different between the bright and the dim light conditions. However, the evening fall and the morning rise of rectal temperature were significantly greater in the bright light conditions on Day 2 compared to the dim. Furthermore, cosinor analysis showed that the acrophase of rectal temperature rhythm was earlier on Day 2 in the bright light conditions than the dim, and was significantly delayed on Day 2 compared to Day 1 in the dim light conditions. These results suggest that low intensity during the daytime for two consecutive days may induce a phase delay of core temperature rhythm rather than the bright light exposure at least in normally entrained female subjects.  (+info)

Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy. (7/9125)

BACKGROUND: Hypertension is a recognized marker of poor prognosis in IgA nephropathy. METHODS: The present study investigated the prevalence of white-coat hypertension, the diurnal rhythm of blood pressure (BP), the effectiveness of antihypertensive drug therapy, and the effect of the above on the progression of the kidney disease in IgA nephropathy. One hundred twenty-six IgA nephropathy patients were selected consecutively for 24-h ambulatory blood pressure monitoring (ABPM). Fifty-five patients were normotensive and 71 were treated hypertensives. Their antihypertensive drugs were angiotensin-converting enzyme inhibitors (ACEI) alone or in combination with calcium-channel blockers (CCB). RESULTS: The mean night-time BP of normotensives (108+/-9/67+/-6 mmHg) was significantly lower than their day-time BP (125+/-8/82+/-7 mmHg, P<0.05). There was no significant difference between the mean day-time and night-time BP in hypertensive patients (125+/-9/82+/-7 mmHg vs 128+/-10/85+/-9 mmHg). The circadian variation of BP was preserved ('dippers') in 82% of the normotensive and 7% of the hypertensive patients (P<0.001). There were 10 'white-coat hypertensives' among the patients classified as normotensives with ABPM (mean office blood pressure 149+/-7/96+/-8 mmHg, 24-h blood pressure 127+/-6/83+/-5 mmHg, P<0.05) and 14 among treated hypertensives (mean office BP 152+/-8/98+/-6 mmHg, 24-h BP 130+/-4/85+/-8 mmHg, P<0.05). There was no difference in mean day-time BP among normotensive and treated hypertensive patients (125+/-8/81+/-5 mmHg vs 128+/-10/85+/-9 mmHg). Hypertensives had significantly higher night-time BP (125+/-9/85+/-9 mmHg) than normotensives (108+/-9/67+/-6 mmHg, P<0.001). There was no difference in serum creatinine levels among the different groups at the time of the ABPM. However, thirty-six+/-4.1 months after the ABPM, hypertensive patients (n=52) had higher serum creatinine levels (124+/-32 micromol/l) than at the time of the ABPM (101+/-28 micromol/l). The serum creatinine of normotensive patients (n=43) did not change during the follow-up period. 'Non-dipper' normotensives (n=10) had significantly higher serum creatinine levels at the end of the follow-up period than at its beginning (106+/-17 micromol/l vs 89+/-18 micromol/l, P<0.05). There was no increase in serum creatinine of 'dipper' normotensives. The mean serum creatinine of 'white-coat hypertensives' was significantly higher at the end of the study period than at its beginning. CONCLUSIONS: There is no diurnal blood pressure variation in most of the hypertensive IgA nephropathy patients. ACEI and CCB treatment have better effect on day-time than night-time hypertension. The lack of the circadian rhythm and 'white-coat hypertension' seems to accelerate the progression of IgA nephropathy.  (+info)

Diurnal variation and age differences in the biochemical markers of bone turnover in horses. (8/9125)

Biochemical markers of bone turnover provide sensitive, rapid, and noninvasive monitoring of bone resorption and formation. Serum concentrations of osteocalcin (OC) reflect rates of bone formation, and urinary concentrations of the pyridinium crosslinks pyridinoline (Pyd) and deoxypyridinoline (Dpd) are specific and sensitive markers of bone resorption. These markers are age-dependent and are used to detect and monitor changes in the rates of bone turnover in a variety of orthopedic diseases in humans and may prove to have similar application in horses. This study examined age differences and diurnal variation in OC, Pyd, and Dpd in eight adult geldings and seven weanling colts. Blood and urine were collected at regular intervals over 24 h. Serum OC and cortisol, and urinary Pyd and Dpd were analyzed. Mean 24-h concentrations of cortisol and all three markers were higher (P<.003) in weanlings than adults. Significant 24-h variation was observed in adult gelding OC, Pyd, and Dpd concentrations (P< .02). Adult OC concentrations were highest between 2400 and 0900; Pyd and Dpd peaked between 0200 and 0800. Similar patterns of bone turnover were observed in weanling values, but they were not significant (P>.17) owing to greater variability between individuals. Cortisol secretion varied (P<.001) over 24 h in both adults and weanlings and, thus, did not seem to be responsible for greater variability in markers of bone turnover between weanlings. These data demonstrate that diurnal rhythms exist for serum OC and urinary Pyd and Dpd in adult horses, as reported in humans, and that sample timing is an important consideration in future equine studies using these markers.  (+info)

Circadian rhythm is the internal biological clock that regulates the sleep-wake cycle. It is controlled by a small group of cells in the brain called the suprachiasmatic nucleus (SCN), which responds to light and dark signals from the environment to synchronize our bodily functions with the 24-hour day-night cycle.

Sleep disorders can be caused by disruptions to the body's natural circadian rhythm, such as shift work sleep disorder, jet lag, or exposure to artificial light at night. These disruptions can lead to difficulty falling asleep, staying asleep, or experiencing poor quality sleep, which can have negative effects on physical and mental health.

Treatment for sleep disorders often involves a combination of lifestyle changes, such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment. Medications or other therapies may also be prescribed to help regulate sleep patterns or manage symptoms.

In addition to disrupting circadian rhythm, sleep disorders can also have other causes, such as stress, anxiety, depression, or certain medical conditions like sleep apnea. It is important to seek medical advice if you are experiencing persistent sleep problems or difficulty functioning during the day due to poor sleep.

Chronobiology disorders can result when the body's natural circadian rhythm is disrupted or altered, leading to problems with sleep timing, duration, and quality, as well as other physiological and behavioral issues. Examples of chronobiology disorders include:

1. Circadian rhythm sleep disorders: These are conditions that affect the body's natural sleep-wake cycle, such as delayed sleep phase syndrome (DSPS) and advanced sleep phase disorder (ASPD).
2. Jet lag: This occurs when traveling across time zones, causing a mismatch between the body's internal clock and the local environment.
3. Shift work sleep disorder: This affects people who work outside of traditional daytime hours and experience difficulty adjusting to irregular sleep schedules.
4. Irregular sleep-wake patterns: This can be caused by factors such as working night shifts, rotating shifts, or having an irregular sleep schedule.
5. Sleep apnea: A sleep disorder in which a person's breathing is interrupted during sleep, often causing them to wake up frequently throughout the night.
6. Insomnia: Difficulty falling asleep or staying asleep, often caused by stress, anxiety, or other factors that disrupt the body's natural sleep-wake cycle.
7. Depression: A mood disorder that can affect the body's circadian rhythm, leading to changes in sleep patterns and other physiological functions.
8. Bipolar disorder: A mood disorder that can cause changes in sleep patterns, energy levels, and other physiological functions.
9. Seasonal affective disorder (SAD): A type of depression that occurs during the winter months when there is less sunlight.
10. Hypersomnia: Excessive sleepiness or prolonged periods of sleep, often caused by factors such as medication side effects, sleep disorders, or other medical conditions.

It's important to note that these are just a few examples of the many potential causes of irregular sleep patterns, and there may be other underlying factors that contribute to this symptom. If you are experiencing persistent changes in your sleep patterns, it is important to speak with a healthcare professional to determine the cause and find appropriate treatment.

Jet lag is also known as desynchronosis or traveler's exhaustion. It occurs when our body's natural sleep-wake cycle, regulated by an internal biological clock, is disrupted due to rapid travel across different time zones. The circadian rhythm, which controls the release of hormones and other physiological processes, takes time to adjust to the new time zone, leading to symptoms such as:

* Fatigue
* Insomnia or excessive sleepiness
* Confusion and disorientation
* Digestive problems such as constipation or diarrhea
* Mood disturbances like irritability or depression

The severity of jet lag can vary depending on the number of time zones crossed, with longer flights causing more significant disruptions to our internal clock. Additionally, some people may be more sensitive to jet lag than others due to individual differences in sleep patterns and circadian rhythms.

There are several strategies that can help alleviate the symptoms of jet lag, such as:

* Gradually adjusting sleep schedules before traveling
* Avoiding caffeine and alcohol, which can disrupt sleep patterns further
* Exposure to sunlight or bright artificial light to help regulate our circadian rhythm
* Taking melatonin supplements to help reset our internal clock.

While jet lag is a temporary condition that usually resolves within a few days, it can have significant impacts on our daily activities and overall well-being during the adjustment period. Therefore, understanding the definition of jet lag syndrome and its causes is essential for managing this common travel-related disorder.

SAD is thought to be caused by the lack of sunlight during the winter months, which can disrupt the body's internal clock and affect the production of neurotransmitters such as serotonin and melatonin. This can lead to feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed.

Treatment for SAD may include light therapy, which involves exposure to bright artificial light that mimics natural sunlight, as well as other forms of therapy such as cognitive-behavioral therapy (CBT) and medication. Lifestyle changes such as regular exercise, social support, and improving sleep habits can also be helpful in managing symptoms of SAD.

The effects of sleep deprivation can be severe and long-lasting, including:

1. Impaired cognitive function: Sleep deprivation can affect attention, memory, and decision-making skills, making it more difficult to perform daily tasks and make sound judgments.
2. Emotional distress: Lack of sleep can lead to irritability, anxiety, and depression, which can negatively impact relationships and overall well-being.
3. Physical health problems: Chronic sleep deprivation has been linked to an increased risk of obesity, diabetes, cardiovascular disease, and immune system dysfunction.
4. Impaired motor function: Sleep deprivation can cause coordination problems, clumsiness, and a higher risk of accidents, particularly in activities that require attention and quick reflexes (e.g., driving).
5. Premature aging: Chronic sleep deprivation can accelerate the aging process and reduce the body's ability to repair and regenerate cells.
6. Reduced productivity and performance: Sleep deprivation can lead to decreased productivity, poor work quality, and increased absenteeism, which can negatively impact career advancement and financial stability.
7. Increased risk of accidents and injuries: Drowsy driving and workplace accidents are common consequences of sleep deprivation, which can result in fatalities and long-term disabilities.
8. Weakened immune system: Sleep deprivation can weaken the immune system, making it more difficult to fight off infections and diseases.
9. Negative impact on relationships: Sleep deprivation can lead to mood swings, irritability, and difficulty interacting with others, which can strain personal and professional relationships.
10. Increased risk of mental health disorders: Chronic sleep deprivation has been linked to an increased risk of developing anxiety, depression, and other mental health disorders.

To avoid these negative consequences, it's essential to prioritize sleep and make it a critical component of your daily routine. Establishing a consistent sleep schedule, creating a sleep-conducive environment, and practicing relaxation techniques can help improve sleep quality and duration. Additionally, avoiding stimulating activities before bedtime, limiting exposure to electronic screens, and seeking professional help if sleep problems persist can contribute to better overall health and well-being.

People with dyssomnia may experience symptoms such as:

* Difficulty falling asleep
* Waking frequently during the night
* Waking too early in the morning
* Feeling groggy or disoriented upon waking
* Poor quality sleep

Dyssomnia can be caused by a variety of factors, including stress, anxiety, depression, chronic pain, sleep disorders, and certain medications. Treatment options for dyssomnia may include lifestyle changes, such as establishing a regular sleep schedule and avoiding caffeine and alcohol before bedtime, as well as cognitive behavioral therapy, relaxation techniques, and in some cases, medication.

It is important to note that dyssomnia is not a specific sleep disorder, but rather a term used to describe a group of related conditions. If you are experiencing difficulty sleeping or poor quality sleep, it is important to speak with a healthcare professional for proper diagnosis and treatment.

There are several risk factors for developing AF, including:

1. Age: The risk of developing AF increases with age, with the majority of cases occurring in people over the age of 65.
2. Hypertension (high blood pressure): High blood pressure can damage the heart and increase the risk of developing AF.
3. Heart disease: People with heart disease, such as coronary artery disease or heart failure, are at higher risk of developing AF.
4. Diabetes mellitus: Diabetes can increase the risk of developing AF.
5. Sleep apnea: Sleep apnea can increase the risk of developing AF.
6. Certain medications: Certain medications, such as thyroid medications and asthma medications, can increase the risk of developing AF.
7. Alcohol consumption: Excessive alcohol consumption has been linked to an increased risk of developing AF.
8. Smoking: Smoking is a risk factor for many cardiovascular conditions, including AF.
9. Obesity: Obesity is a risk factor for many cardiovascular conditions, including AF.

Symptoms of AF can include:

1. Palpitations (rapid or irregular heartbeat)
2. Shortness of breath
3. Fatigue
4. Dizziness or lightheadedness
5. Chest pain or discomfort

AF can be diagnosed with the help of several tests, including:

1. Electrocardiogram (ECG): This is a non-invasive test that measures the electrical activity of the heart.
2. Holter monitor: This is a portable device that records the heart's rhythm over a 24-hour period.
3. Event monitor: This is a portable device that records the heart's rhythm over a longer period of time, usually 1-2 weeks.
4. Echocardiogram: This is an imaging test that uses sound waves to create pictures of the heart.
5. Cardiac MRI: This is an imaging test that uses magnetic fields and radio waves to create detailed pictures of the heart.

Treatment for AF depends on the underlying cause and may include medications, such as:

1. Beta blockers: These medications slow the heart rate and reduce the force of the heart's contractions.
2. Antiarrhythmics: These medications help regulate the heart's rhythm.
3. Blood thinners: These medications prevent blood clots from forming and can help reduce the risk of stroke.
4. Calcium channel blockers: These medications slow the entry of calcium into the heart muscle cells, which can help slow the heart rate and reduce the force of the heart's contractions.

In some cases, catheter ablation may be recommended to destroy the abnormal electrical pathway causing AF. This is a minimally invasive procedure that involves inserting a catheter through a vein in the leg and guiding it to the heart using x-ray imaging. Once the catheter is in place, energy is applied to the abnormal electrical pathway to destroy it and restore a normal heart rhythm.

It's important to note that AF can increase the risk of stroke, so anticoagulation therapy may be recommended to reduce this risk. This can include medications such as warfarin or aspirin, or in some cases, implantable devices such as a left atrial appendage closure device.

In conclusion, atrial fibrillation is a common heart rhythm disorder that can increase the risk of stroke and heart failure. Treatment options depend on the underlying cause and may include medications, cardioversion, catheter ablation, or anticoagulation therapy. It's important to work closely with a healthcare provider to determine the best course of treatment for AF.

1. Insomnia: difficulty falling asleep or staying asleep
2. Sleep apnea: pauses in breathing during sleep
3. Narcolepsy: excessive daytime sleepiness and sudden attacks of sleep
4. Restless leg syndrome: uncomfortable sensations in the legs during sleep
5. Periodic limb movement disorder: involuntary movements of the legs or arms during sleep
6. Sleepwalking: walking or performing other activities during sleep
7. Sleep terrors: intense fear or anxiety during sleep
8. Sleep paralysis: temporary inability to move or speak during sleep
9. REM sleep behavior disorder: acting out dreams during sleep
10. Circadian rhythm disorders: disruptions to the body's internal clock, leading to irregular sleep patterns.

Sleep disorders can be caused by a variety of factors, such as stress, anxiety, certain medications, sleep deprivation, and underlying medical conditions like chronic pain or sleep apnea. Treatment for sleep disorders may include lifestyle changes (such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment), medications, and behavioral therapies (such as cognitive-behavioral therapy for insomnia). In some cases, surgery or other medical interventions may be necessary.

It is important to seek medical attention if you suspect that you or someone you know may have a sleep disorder, as untreated sleep disorders can lead to serious health problems, such as cardiovascular disease, obesity, and depression. A healthcare professional can help diagnose the specific sleep disorder and develop an appropriate treatment plan.

In clinical settings, an abnormal circadian rhythm in humans is known as a circadian rhythm sleep disorder. While there are ... ISBN 978-0-674-13581-9. Wikimedia Commons has media related to Circadian rhythm. Circadian rhythm at Curlie (Wikipedia articles ... Actigraphy (also known as actimetry) ARNTL ARNTL2 Bacterial circadian rhythms Circadian rhythm sleep disorders, such as ... the circadian rhythm continues to be disrupted. The stabilization of sleep and the circadian rhythm might possibly help to ...
Bacterial circadian rhythms, like other circadian rhythms, are endogenous "biological clocks" that have the following three ... have well-documented circadian rhythms that meet all the criteria of bona fide circadian rhythms. In these bacteria, three key ... Circadian rhythm Chronobiology Cyanobacteria Johnson CH, Golden SS, Ishiura M, Kondo T (July 1996). "Circadian clocks in ... In the context of bacterial circadian rhythms, specifically in cyanobacteria, circadian advantage refers to the improved ...
Biological rhythms were first studied in Drosophila. Drosophila circadian rhythm have paved the way for understanding circadian ... Thus, the clock is reset to commence the next circadian cycle. Dubowy, Christine; Sehgal, Amita (2017). "Circadian Rhythms and ... This is because the circadian clocks are fundamentally similar. Drosophila circadian rhythm was discovered in 1935 by German ... there was no circadian rhythm; in one mutation (called perS, "S" for short or shortened) the rhythm was shortened to ~19 hours ...
The Journal of Circadian Rhythms is a peer-reviewed open access scientific journal covering circadian and nycthemeral (daily) ... rhythms in living organisms, including processes associated with photoperiodism and daily torpor. It was established in 2003 ...
... s (CRSD), also known as circadian rhythm sleep-wake disorders (CRSWD), are a family of sleep ... Some misconceptions regarding circadian rhythms and sleep commonly mislabel irregular sleep as a circadian rhythm sleep ... which are collectively referred to as circadian rhythm sleep disorders. A circadian rhythm is an entrainable, endogenous, ... "Behavioral Treatment of Circadian Rhythm Disorder". WebMD. Retrieved 2021-06-24. Dagan Y (February 2002). "Circadian rhythm ...
Chronobiology Circadian advantage Circadian clock Circadian oscillator Circadian rhythm disorders Electronic media and sleep ... Light effects on circadian rhythm are the effects that light has on circadian rhythm. Most animals and other organisms have " ... and alterations to the circadian rhythm. While light has direct effects on circadian rhythm, there are indirect effects seen ... The human circadian rhythm occurs typically in accordance with nature's cycle. The average activity rhythm cycle is 24.18 hours ...
In 2007, Stoleru found that the M cells dominate the circadian rhythm on short days while the E cells dominate the rhythm on ... In the field of chronobiology (the study of circadian rhythms), the dual circadian oscillator model refers to a model of ... have shown circadian rhythms in conidiation patterns when observed under constant darkness. These rhythms appear to be under ... They postulated that the E&M model had an enhanced ability to adjust the circadian rhythm to the season and changes in day ...
"Circadian Rhythms". Fahey, Christopher D.; Zee, Phyllis C. (1 December 2006). "Circadian rhythm sleep disorders ... The human circadian rhythm can be affected by light sources. The effective color temperature of daylight is ~5,700K (bluish ... People who have circadian rhythm sleep disorders are sometimes treated with light therapy (exposure to intense bluish white ... determines circadian phase". Sleep Medicine. 14 (5): 456-461. doi:10.1016/j.sleep.2012.12.011. PMC 4304650. PMID 23481485. "AMA ...
Circadian Rhythms. Methods Mol. Biol. Methods in Molecular Biology. Vol. 362. pp. 315-27. doi:10.1007/978-1-59745-257-1_22. ...
... the circasemidian rhythm may be the first harmonic of the circadian rhythm and not an intrinsic rhythm. However, a number of ... It may also be called the semicircadian rhythm . Numerous studies have demonstrated that human circadian rhythms in many ... Harris W. "Fatigue, circadian rhythm, and truck accidents". Chapter 8 in Mackie RR (ed.), Vigilance: Operational Performance, ... Colquhoun WP, Paine MWPH, Fort A. "Circadian rhythm of body temperature during prolonged undersea voyages". Aviat Space Environ ...
Yonah's Dream, Circadian Rhythms, Two Harmonies, Under The Rainbow, The Big Rip. Newband, Dave Eggar and Deoro, Wendy Richman, ... Circadian Rhythms. Newband. Mode Records. Throat. Jean Kopperud, clarinet, Tom Kolor, percussion. Albany Records. Shadow Waltz ... "Circadian Rhythms". New World Records Catalog website. September 5, 2012. Retrieved December 31, 2018. "Extreme Measures II". ... Circadian Rhythms for cello, percussion, and two keyboards (one player) (1989) Continental Drift for horn, percussion, and two ...
"Circadian Rhythm". November 18, 2010. Retrieved December 21, 2016. New TV series dresses up local landmarks ... a young woman on a journey to discover who she is and why multiple enemies want her dead in the action film Circadian Rhythm. ...
The symptoms are caused by a circadian rhythm that is out of sync with the day-night cycle of the destination, as well as the ... Jet lag was previously classified as one of the circadian rhythm sleep disorders. The condition of jet lag may last several ... Most people have an endogenous circadian rhythm that is longer than 24 hours, so lengthening a day is less troublesome than ... It does not necessarily involve the shift in circadian rhythms that cause jet lag. Travel fatigue can occur without crossing ...
Fetuses aged 14 to 18 weeks show a pronounced circadian rhythm in their activity level, which can be detected both by fetal ... J Circadian Rhythms. 3 (1): 5. doi:10.1186/1740-3391-3-5. PMC 1079927. PMID 15801976. Vaughan, Christopher (1996). How Life ...
... is "available to crew to optimize performance while fatigued" and helps with the disruptions in circadian rhythms and ... November 2007). "Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American ... Zee PC, Attarian H, Videnovic A (February 2013). "Circadian rhythm abnormalities". Continuum. 19 (1 Sleep Disorders): 132-147. ...
A video showing circadian rhythms in a cucumber plant in constant conditions, similar to what de Mairan observed, can be seen ... de Mairan's paper can be accessed here, together with its analysis in the light of present views of circadian rhythms. That ... His observations and experiments also inspired the beginning of what is now known as the study of biological circadian rhythms ... In 1729, de Mairan constructed an experiment showing the existence of a circadian rhythm in plants, presumably originating from ...
Circadian rhythm issues. Information overload. In the capacity of the individual: Lack of familiarity with the task, lack of ...
... and circadian rhythms impact the human metabolome. Archer, Simon N, et al. "A Length Polymorphism in the Circadian Clock Gene ... "Circadian Rhythm Disorders". National Heart, Lung, and Blood Institute. Lockly, S W; Skene, D J; James, K; Thapan, K; Wright, J ... "Separation of Circadian- and Behavior-Driven Metabolite Rhythms in Humans Provides a Window on Peripheral Oscillators and ... "Phase Advancing Human Circadian Rhythms with Short Wavelength Light." Neuroscience Letters, vol. 342, no. 1-2, 15 May 2003, pp ...
Circadian Rhythm Disorder (2015) Snelwar, Glen (8 March 2015). "Circadian Rhythm Disorder". Glenn Snelwar Blog. Snelwar, Glenn ... Marco Minnemann plays drums in Circadian Rhythm Disorder (2015), which is actually another version of Minnemann's drum solo ... for Circadian Rhythm Disorder: Marco Minnemann - drums, percussion Torn Between Dimensions (2005) Acts of God (2007) A Familiar ...
Liu, Yi; Bell-Pedersen, Deborah (2017-04-27). "Circadian Rhythms in Neurospora crassa and Other Filamentous Fungi". Eukaryotic ... McClung, C. Robertson (2006-04-01). "Plant Circadian Rhythms". The Plant Cell. 18 (4): 792-803. doi:10.1105/tpc.106.040980. ... TOC1 (gene) CCA1 Circadian Clock Salomé, Patrice A.; McClung, C. Robertson (2004). "The Arabidopsis thaliana Clock". Journal of ... Matsushika, Akinori (2000). "Circadian Waves of Expression of the APRR1/TOC1 Family of Pseudo-Response Regulators in ...
"Circadian Rhythm Information". Retrieved 2010-10-07. Zee PC, Vitiello MV (June 2009). "Circadian Rhythm Sleep Disorder: ... Irregular sleep-wake rhythm (ISWD) is a rare form of circadian rhythm sleep disorder. It is characterized by numerous naps ... The current formally correct name of the disorder is Circadian Rhythm Sleep Disorder: Irregular Sleep Wake Rhythm Type. This ... Zee PC, Vitiello MV (June 2009). "Circadian Rhythm Sleep Disorder: Irregular Sleep Wake Rhythm Type". Sleep Medicine Clinics. ...
McClung, C. Robertson (2006). "Plant Circadian Rhythms". The Plant Cell. 18 (4): 792-794. doi:10.1105/tpc.106.040980. PMC ... Stephan, Friedrich K; Zucker, Irving (1972). "Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are ... Moore, Robert; Eichler, Victor (July 1972). "Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic ... and studies that showed the persistence of circadian rhythm in the South Pole and in a space lab further confirmed the ...
... s are the central mechanisms that drive circadian rhythms. They consist of three major components: a central ... See section "regulation of circadian oscillators" below for more details. Evidence for a genetic basis of circadian rhythms in ... This group discovered circadian rhythms in redox proteins (peroxiredoxins) in cells that lacked a nucleus - human red blood ... In bacterial circadian rhythms, the oscillations of the phosphorylation of cyanobacterial Kai C protein was reconstituted in a ...
In the management of circadian rhythm disorders such as delayed sleep phase disorder (DSPD), the timing of light exposure is ... Morning therapy has provided the best results because light in the early morning aids in regulating the circadian rhythm. ... Zisapel, Nava (2001). "Circadian Rhythm Sleep Disorders". CNS Drugs. 15 (4): 311-328. doi:10.2165/00023210-200115040-00005. ... Dodson, Ehren R.; Zee, Phyllis C (December 2010). "Therapeutics for Circadian Rhythm Sleep Disorders". Sleep Medicine Clinics. ...
The hormones cortisol and melatonin are an important part of the circadian rhythm. In circadian misalignment, cortisol and ... "JCDR - Circadian rhythm, Night shift, Sleep quality". Retrieved 2021-09-28. "Can nurses' shift work jeopardize the ... Brain arousal is stimulated by the circadian system during the day and sleep is usually stimulated at night. The rhythms are ... Eastman CI, Stewart KT, Mahoney MP, Liu L, Fogg LF (September 1994). "Dark goggles and bright light improve circadian rhythm ...
2003-10-29). "Transdisciplinary unifying implications of circadian findings in the 1950s". Journal of Circadian Rhythms. 1 (2 ... In the 1950s, he introduced the word circadian, which derives from the Latin about (circa) a day (diem). Halberg was nominated ... Eventually I reverted, for the same reason, to "circadian" ... Fernholm B., Bremer K., Jörnvall H. (eds.). The Hierarchy of ...
One variable tested in the bunker experiment was whether light intensity affected the period of the circadian rhythm. To ... Scientists also studied the genetic basis of circadian rhythms. Ronald Konopka and Seymour Benzer discovered the period gene in ... Aschoff J, Gerecke U, Wever R (August 1967). "Desynchronization of human circadian rhythms". The Japanese Journal of Physiology ... Aschoff J (June 1965). "CIRCADIAN RHYTHMS IN MAN". Science. 148 (3676): 1427-32. doi:10.1126/science.148.3676.1427. PMID ...
This provided evidence for the notion that each cotyledon is sufficient for maintaining an independent circadian rhythm and has ... This demonstrated that the KaiABC proteins are sufficient for maintaining circadian rhythm when provided with ATP. It also ... Cohen SE, Golden SS (December 2015). "Circadian Rhythms in Cyanobacteria". Microbiology and Molecular Biology Reviews. 79 (4): ... "A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless". Cell. 93 ( ...
"Palaeochronobiology circadian rhythms, gauges of adaptive Darwinian evolution: about 7-day circaseptan rhythms, gauges of ... Circadian rhythm Chronobiology "circaseptan". Retrieved 30 March 2017 - via The Free Dictionary. Macey, Samuel L. (1994). ... A circaseptan rhythm is a cycle consisting of approximately 7 days in which many[which?] biological processes of life, such as ... 1987: Circaseptan rhythm in sodium and potassium excretion in salt-sensitive and salt-resistant 'Dahl rats'". Progr Clin Biol ...
Patients with circadian rhythm sleep disorders often have difficulty maintaining ordinary social lives, and some of them lose ... Taken this late, it does not, of itself, affect circadian rhythms, but a decrease in exposure to light in the evening is ... Misdiagnosis of circadian rhythm sleep disorders as psychiatric conditions causes considerable distress to patients and their ... "Sleeplessness and Circadian Rhythm Disorder". eMedicine World Medical Library from WebMD. Retrieved 4 June 2006. Implicit in ...
... and circadian rhythms. He served on advisory panels for NIH, NSF, FDA, NASA, and FASEB. Yates was a founding member and past ...
On The Circadian Rhythms) (4:14) Carousel (0:38) Yantra (3:54) Opus Of The Black Sun (6:29) Marylebone Road (4:12) Tiny Space ...
This not only adds stress to their daily life but also influences an individual's circadian rhythm. The circadian rhythm is ... Sleep is regulated by an internal process known as the circadian rhythm. This 24-hour cycle regulates periods of alertness and ... as the average circadian rhythm would support. Another main contributor to the development of occupational stress in employees ... Not only is IL-6 influenced by the circadian rhythm but its effectiveness is increased by sleep itself as there is an increase ...
She investigated circadian rhythms in photoluminescent dinoflagellates, and other single celled organisms. Later in her career ... She continued her research into circadian rhythms for the rest of her career, publishing her monograph Rhythmic Phenomena in ... Sweeney is a world-respected innovator in the study of circadian rhythms, particularly in the dinoflagellates. By bringing ... Sweeney, Beatrice M.; Borgese, M. Beatriz (March 1989). "A Circadian Rhythm in Cell Division in a Prokaryote, the ...
He headed the chemistry and physiology lab studying insect neurobiology, gut physiology, the chemistry of circadian rhythms and ...
The development of spinules in the eye may be affected by dopamine, circadian rhythms, and exposure to light or dark ...
New and Rediscovered Musical Instruments' with David Toop, produced by Brian Eno (Obscure) - 1975 'Circadian Rhythm' with Paul ...
These findings suggest that normalization of the hypothalamic-pituitary-adrenal axis and the circadian sleep-wake cycle may be ... abnormal heart rhythms (e.g., sinus tachycardia, bradycardia, and atrioventricular block) Allergic/toxic: skin rash, ...
In the late 1990s she moved to the United States, appearing in several minor roles including the 2005 film Circadian Rhythm and ...
Circadian resulted from an interest in the effects of cycles and in the ways human individual rhythms interact with nature. It ... Circadian is a concept album and the first full-length studio album by 5th Projekt. It was released on August 29, 2006 on 5th ... The lid of the tin displays an ambigram of the title "Circadian," further emphasizing the predominant themes of unity and ...
The Influence of Local Meteorological Conditions on the Circadian Rhythm of Corn (Zea Mays L.) Pollen Dispersal into the ...
... or circadian rhythms of heat production. Additionally, human space travelers are often not well hydrated, have a 10-15% ... and post-flight testing within a similar circadian schedule. The effect of these uncontrollable conditions and that of other ...
Neurons there show activity levels that rise and fall with a period of about 24 hours, circadian rhythms: these activity ... Antle, MC; Silver, R (2005). "Orchestrating time: arrangements of the brain circadian clock" (PDF). Trends in Neurosciences. 28 ... ISBN 978-0-7817-5126-1. Buzsáki, Gyorgy (2006). Rhythms of the Brain. Oxford University Press. ISBN 9780199828234. Nieuwenhuys ...
iTechExplorers - Collation & Sharing of Data Related to Affects of Technology on Circadian Rhythms. ECSA is one of the founders ...
... identified key genes involved in mammalian circadian rhythms Emma Vyssotsky - astronomer at the University of Virginia Peter J ...
... caused by these infections usually occur on circadian rhythms. Over the course of a viral infection, sinusitis (the ...
Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology 2009; 73:323-25. ...
The objective of this experiment was to determine the functioning of a primate's circadian rhythm and thermoregulatory systems ... was to determine the effect of microgravity on selected pineal gland neurotransmitters associated with rodent circadian rhythm ...
Circadian rhythm List of sovereign states by suicide rate Clauss-Ehlers, Caroline (2010). "Encyclopedia of Cross-Cultural ... Touitou, Y.; Haul, E. (1992). "Biologic rhythms from biblical to modem times: a preface". Biologic Rhythms in Clinical and ... no regular annual rhythm". The Greek researchers proposed that "the seasonal variation of suicide follows more closely to the ... "the significant seasonal rhythm were explained in 63% of the total variation". According to Bridges, recent research from ...
Circadian rhythm and the higher-order factors of the Big Five. Personality and Individual Differences, 43, 267-276. DeYoung, C ...
The possible consequences are alteration in circadian rhythm and righting reflex, ataxia and analgesia. Angelicin demonstrates ...
Park SY, Walker JJ, Johnson NW, Zhao Z, Lightman SL, Spiga F (May 2013). "Constant light disrupts the circadian rhythm of ... It is well known that levels of corticosterone (CORT, cortisol in humans) secretion demonstrate a circadian rhythm, highly ... ACTH levels, ACTH receptor expression, and MRAP1 expression also demonstrate circadian rhythm, with ACTH secretion and MRAP ...
... studies indicate disrupted circadian rhythms when using THC. Furthermore, THC is shown to have a quicker development of ... tetrahydrocannabinol increases brain temperature and inverts circadian rhythms". NeuroReport. 12 (17): 3791-4. doi:10.1097/ ...
The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be ... 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations ... function and prevalence in subjects with circadian rhythm sleep disorders". Biochemical and Biophysical Research Communications ... "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses". Neuron. 13 ...
The shifted circadian rhythms associated with puberty make it difficult, if not impossible, for many teenagers-who may have to ... "Changes in circadian rhythms during puberty in Rattus norvegicus: Developmental time course and gonadal dependency". Hormones ... In 1993, a team led by Mary Carskadon, PhD, of Brown University showed that changes in circadian biology during puberty drive a ... "Teensleep". Sleep & Circadian Neuroscience Institute. University of Oxford. 2015. Retrieved 21 April 2016. Snider, Terra ...
... circadian rhythm, and carbohydrate and lipid metabolism in the treated group relative to the control group following 3 years of ... "Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people". Adv Gerontol ...
Circadian rhythm, Ethology, Nocturnal animals, Predation, Sleep). ...
A study of circadian rhythms was concerned with the synchronization of primate motor activity, body temperature and skin ... temperature rhythms to a fixed light/dark cycle and to each other. Blood pressure and flow were monitored, to evaluate short ...
... speculates that recorded delays in the system's chemical reactions point to biological activity similar to the circadian rhythm ...
Agostino, P. V.; Plano, S. A.; Golombek, D. A. (2007). "Sildenafil accelerates reentrainment of circadian rhythms after ...
Circadian Rhythms. Circadian rhythms are internally driven cycles of biochemical, physiological, and behavioral processes of ... throughout the human body that drive circadian rhythms. A master circadian pacemakera (sometimes called the circadian clock) in ... Circadian rhythms promote sleepiness before usual bedtime, help initiate sleep, and begin promoting wakefulness before usual ... As well as sleep and wakefulness, the pacemaker sets the timing for numerous circadian rhythms that regulate physiological and ...
Cite this: Sleep, Circadian Rhythms, Delirium, and the ICU - Medscape - May 08, 2023. ... On the heels of their research statement on cancer fatigue, theyve issued another on sleep and circadian disorders (SCD) in ...
Adults with healthy memories whove had disrupted circadian rhythms (or sleep cycles) have protein buildups that can serve as ... The researchers also disrupted the sleep rhythms of mice in another study and found that doing so led to a buildup of amyloid ... A study recently published in the journal JAMA Neurology found that adults with healthy memories who had disrupted circadian ... rhythms - also known as sleep cycles - had protein buildups of a substance called amyloid plaque, which can serve as an early ...
Find tickets for Circadian Rhythm concerts near you. Browse 2023 tour dates, venue details, concert reviews, photos, and more ... About Circadian Rhythm. Circadian Rhythm was formed in the summer of 2012, It was then that Craig and John decided that it was ... About Circadian Rhythm. Circadian Rhythm was formed in the summer of 2012, It was then that Craig and John decided that it was ... With many show dates and possible tours this summer,stay tuned to see if Circadian Rhythm is coming to a city near you!!! Out ...
Circadian rhythms are driven by the circadian clock machinery (biological clocks) to ensure that the organism anticipates and ... Auditory function has been shown to be influenced by the circadian system. ...
Results A salivary cortisol circadian rhythm was established by one month corrected age and persisted throughout the first year ... The time to establish salivary cortisol circadian rhythm differed between preterm and full-term infants according to postnatal ... Establishment of salivary cortisol circadian rhythm is related to gestational age rather than to postnatal age. Salivary ... To evaluate whether salivary cortisol circadian rhythm development is related to behavioral regularity. To elucidate salivary ...
... (CRSD). ... "Remarkable breakthroughs in our understanding of the cell biology that controls circadian rhythm make the circadian control ... People with extremely early or extremely late sleep times may suffer from Circadian Rhythm Sleep Disorder. *Download PDF Copy ... Tags: B Cell, Blood, Cardiology, Cell, Cell Biology, Cellular Biology, Circadian Rhythm, Clinical Diagnostics, Depression, ...
... circadian rhythms and how shift work can affect them and their job performance. Funding for this 3-year study was granted in ... Discussion: The study findings will show the current state of the nurses circadian rhythms and how shift work can affect them ... Sleepiness in Spanish nursing staff--influence of chronotype and care unit in circadian rhythm impairment: research protocol J ... Aims: To determine how prevalent circadian rhythm impairments are in nurses working in medical, surgical and intensive care ...
Irvine-led study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and ... The study, titled Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles, was published ... Genetic Research Addiction Brain and Mental Performance Circadian Clock/Rhythm Links Between Circadian Rhythms, Metabolism And ... ...
... 1 Comment / Featured, Health / Well Being / By Peter Bort ... that sets our body circadian (daily) and ultradian (seasonal) clocks. When we set our clocks this way we create better sleep, ...
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Circadian Rhythms That Influence Sleep. Circadian sleep rhythm is one of the several intrinsic body rhythms modulated by the ... The nadir of this rhythm is in the early morning. The downswing in circadian rhythm prior to the nadir is thought to assist the ... Pavlova M. Circadian Rhythm Sleep-Wake Disorders. Continuum (Minneap Minn). 2017 Aug. 23 (4, Sleep Neurology):1051-1063. [QxMD ... Circadian Rhythm Disorders: Part 1, Basic Principles, Shift Work and Jet Lab Disorders. Sleep. November 2007. 30(11):1460-83. [ ...
A synchronized dance of proteins and enzymes within our cells can explain our circadian rhythm, but might they also help ... Why We Wake Up Before Our Alarm: Our Circadian Rhythms Work Against Us When It Comes To Sleep, And Even Age. Nov 21, 2013 04:32 ... A synchronized dance of proteins and enzymes within our cells can explain our circadian rhythm, but might they also help ... The synchronized dance of proteins and enzymes within our cells that help articulate our circadian rhythms can explain both of ...
Circadian rhythm based work scheduling can be effective, particularly for stressful and high-risk tasks; and ... time of day (because of the heat and circadian rhythms) and day of week (depending on the workers predisposition and ... Ergoweb has covered other research regarding circadian rhythms (see related articles on this page, or search the terms using ... Research: A Circadian Rhythms Based Work Scheduling for High Voltage Live Line Electricians. ...
BIMM 116 PSYC 133 - Circadian Rhythms-Bio Clocks - LE [A00]. *Professor Golden, Susan S. ...
The circadian rhythm is the biological "clock" that governs every living organism, including humans. Because it is adapted to ... In fact, six out of the nine circadian rhythm genes, including CLOCK, have already been linked to breast cancer from Zhus ... However, "artificial light in the last 150 years has disrupted many peoples natural circadian rhythm," said Zhu. "People now ... the circadian rhythm is roughly a 24-hour cycle in which the 12 hours of the night correspond to our regular sleeping pattern. ...
The mammalian circadian clock and its associated clock genes are increasingly been recognized as critical components for a ... Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. Author(s): ... Methods: In light of the significant role circadian rhythm can hold over the bodys normal physiology as well as disease ... Tumorigenesis also can occur with the loss of a maintained circadian rhythm and lead to an increased risk for nasopharyngeal ...
Are you curious about how a circadian-based lighting system complements your Boulder, CO, lifestyle? Keep reading below to ... Our biological development and cultural expressions continue to be influenced by the rhythms and cycles of our days. ...
Tag Archives: circadian rhythm 4/21/14: Hit the Lights on Your Way Out. 23 Friday May 2014 ... astronomers, astrophilia, benefits of sleep, cinema, circadian rhythm, city living, darkness, documentaries, documentary, Errol ... Posts about circadian rhythm written by phillipkaragas ...
4. Circadian Rhythm. My blood runs cold, my heart is silent. Rumours around me slowly fade. Clouds are forming and going away. ... Circadian rhythm wont lead me today. Searching a way out of this nothingness. The ultimate ride to escape from reality. Senses ... Circadian Rhythm wont lead me today. I will not break, I will survive. Crossing the bridge between nothing and life ...
Thats because your circadian rhythm is at work. What is a circadian rhythm? Your circadian rhythm is essentially an internal ... If you are well-rested, you wont feel the dips and rises of your circadian rhythm. However, if youre consistently not getting ... The main factor affecting your circadian rhythm is daylight. When night falls, your eyes send a signal to the hypothalamus that ... So to get your circadian rhythm working optimally, maintain regular sleep habits. Aim for a consistent bedtime at night and ...
Tag Archives: Circadian rhythm. 0300 Night Watch. Posted on Dec 17, 2011. by essiep ... Posts about Circadian rhythm written by essiep ... Posted in Health , Tagged Circadian rhythm, Insomnia, Sleep , 1 ...
Timing Is Everything: Circadian Rhythms, Intermittent Fasting, and Metabolism Presented by Amy Shah, MD and Georgia Austin, ... Presentation Deck: Chrononutrition for Circadian Rhythm Synchronization Presented by: Georgia Austin MSACN, CNS, CCN ... Timing Is Everything: Circadian Rhythms, Intermittent Fasting, and Metabolism Practical, personalized, science-based advice for ... Chrononutrition for Circadian Rhythm Synchronization Presented by: Georgia Austin MSACN, CNS, CCN ...
Juneteenth Jubilee Detroit presents Rhythm & Art Block Party - Friday, June 17, 2022 at Eastern Market Brewing Co, Detroit, MI ... Save System Regulation , Nervous System + Hormone + Circadian Rhythm Regulation to your collection.. ... Share System Regulation , Nervous System + Hormone + Circadian Rhythm Regulation with your friends.. ... System Regulation , Nervous System + Hormone + Circadian Rhythm Regulation. System Regulation , Nervous System + Hormone + ...
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Tag: circadian rhythm. Sleeping Problems in Alzheimers and How to Help October 5, 2021 by Dean Bellefeuille ... Filed Under: Alzheimers Disease, Senior Safety, Sleep Issues Tagged With: Alzheimers symptom, circadian rhythm, in-home care ... For reasons that are not yet fully understood, a number of people with dementia experience changes to their circadian rhythm, ...
Tag: circadian rhythms. Melanin Myth #7: Melanin and the Pineal gland. You value truth. Thats why you support ... Categorized as Melanin, melatonin, pineal gland Tagged calcification, calcified, circadian rhythms, gland, melanin, melatonin, ...
... including white tunable LED lighting without a maximum kelvin temperature as they understand that any true circadian light must ... Circadian Rhythm LED lighting, including WalaLight has been unable to apply for testing and approval. The appropriate ... Design Light Consortium appears ready to accept Circadian Rhythm lighting enabling government rebates!. Design Light Consortium ... including white tunable LED lighting without a maximum kelvin temperature as they understand that any true circadian light must ...
  • Several hundred genes in each of six brain regions displayed rhythmic patterns of expression over the 24-hour cycle, including many genes essential to the body's circadian machinery. (
  • A new review paper reports that cancer is intrinsically linked to the body's circadian rhythms. (
  • Staying at least broadly in sync with such rhythms helps the body's circadian-dependent systems to strike the right balance and better achieve homeostasis, or the maintenance of well-functioning cellular processes that contribute to overall health. (
  • Groundbreaking research at the Yale School of Public Health has shown that changes in a gene responsible for regulating the body's circadian rhythm increase the risk of breast cancer in women. (
  • Aircrew members may experience circadian rhythm disruption (specifically "jet lag") as they work. (
  • Here you can learn more about circadian rhythm disruption, why it occurs, possible health effects, and how crewmembers can reduce the effects of circadian disruption. (
  • Why might aircrew be concerned about circadian rhythm disruption? (
  • Although travelers who get circadian disruption after a single flight recover after 1-2 weeks, many crewmembers are continually exposed and show evidence of chronic circadian rhythm disruption. (
  • Some crewmembers may have higher exposure to circadian disruption than most of their coworkers and thus may be at greater risk for possible health effects. (
  • A study we completed found that travel across time zones and work during a flight attendant's normal sleep hours were both linked to chronic circadian disruption in a group of flight attendants. (
  • The World Health Organization says that shift work (including the kind of circadian disruption that aircrew encounter) probably causes cancer. (
  • We don't know what causes most health problems that may be linked to circadian disruption, including some types of cancer as well as reproductive health issues like miscarriage and birth defects. (
  • If you experience circadian disruption and have these health problems, we can't tell if the problem was caused by your work conditions or if it was caused by something else. (
  • We don't know how much circadian disruption is safe for every person. (
  • Bidding for a flight schedule to reduce circadian disruption exposures is complicated, because reducing one exposure may increase another. (
  • These are flight conditions that tend to increase the amount of circadian disruption the aircrew is exposed to. (
  • If you are pregnant or planning a pregnancy, it is important to consider your work exposures, including circadian disruption. (
  • Circadian rhythm disruption has been linked to sleep problems, obesity, and other health issues. (
  • Launch at least 12 new projects focused on understanding the short-term and long-term consequences of disrupted/optimized circadian rhythms and sleep on brain aging and dementia and the mechanistic links between sleep/circadian disruption and AD and AD-related dementias to identify new targets and approaches for AD prevention. (
  • Circadian disruption and breast cancer: from melatonin to clock genes. (
  • Circadian Rhythms are endogenous self-sustaining oscillations that organize the timing of biological systems to optimize physiology and behavior, and health. (
  • The findings provide clues for potential new classes of compounds to rapidly treat depression that may reset abnormal clock genes and normalize circadian rhythms," said Dr. William Bunney, the study's senior author, and Distinguished Professor of Psychiatry & Human Behavior at UC Irvine. (
  • Recent studies have also revealed that circadian system affects metabolic homeostasis while metabolic pathways feed back into the regulation of circadian system and modulate many physiological processes and behavior. (
  • However, many other biological functions such as behavior, metabolic function, cardiovascular, endocrine, digestive and immune systems are under the control of the circadian system. (
  • These oscillations are autonomously generated, are found in most tissues, and establish rhythms in physiology and behavior. (
  • New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. (
  • Disruptions of your sleep-wake cycle that interfere with daily activities may mean that you have a circadian rhythm disorder. (
  • Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). (
  • The aim of the work was to analyze comparatively two measures of stress in girls and teenagers with diagnosis of Turner's syndrome, their stress perception across the Questionnaire for school stress and the circadian cortisol slope determined by salivary cortisol. (
  • circadian cortisol slope. (
  • These clock genes regulate 24-hour circadian rhythms affecting hormonal, body temperature, sleep and behavioral patterns. (
  • Circadian rhythms are our internal body clocks that regulate our sleep patterns and other functions. (
  • Using RNAseq we recently identified 7211 genes (49%) in the cochlea that have circadian expression and a large proportion of these regulate cell signaling, hormone secretion, and inflammation 4 . (
  • This mechanism is conserved within the animal kingdom: similar clock genes regulate patterns of sleep and other rhythms in humans. (
  • Surprisingly, some scientists who delve into this area of research now believe similar rhythms and patterns might regulate aging. (
  • Animals and plants have biological clocks that help to regulate circadian cycles, seasonal rhythms, growth, development, and sexual maturity," J.J. Mitteldorf wrote in a recent article . (
  • Biological clocks are organisms' natural timing devices, regulating the cycle of circadian rhythms. (
  • Circadian rhythms are driven by the circadian clock machinery (biological clocks) to ensure that the organism anticipates and adapts to temporal changes in the environment. (
  • An NIH-funded team has some new clues based on evidence showing how a molecular "switch" wired into the biological clocks of extreme early risers leads them to operate on a daily cycle of about 20 hours instead of a full 24-hour, or circadian (Latin for "about a day"), cycle [1]. (
  • Your internal clock, called a circadian clock, cycles about every 24 hours. (
  • These repeating 24-hour cycles are called the circadian rhythm. (
  • A study recently published in the journal JAMA Neurology found that adults with healthy memories who had disrupted circadian rhythms - also known as sleep cycles - had protein buildups of a substance called amyloid plaque, which can serve as an early sign of Alzheimer's. (
  • The word "circadian" is based on the Latin terms for "around" (circa) and "day" (diem), so your "around-the-day" rhythm dictates the cycles your body goes through-most notably when you wake up and fall asleep. (
  • Exposing yourself to natural light in the morning and avoiding screens and other sources of artificial light in the evening prior to bed will help align your sleep cycles and reinforce your circadian rhythm (regular light and dark times are a key factor as well). (
  • Background: The mammalian circadian clock and its associated clock genes are increasingly been recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. (
  • Dr. Young's laboratory has identified genes that control the circadian rhythms of Drosophila. (
  • By studying blood samples from a case-control study of breast cancer as well as the MCF7 breast cancer cell line, Zhu and his lab were able to show that both genetic and epigenetic changes in the CLOCK gene , one of the nine core genes that control our circadian rhythm, can serve as susceptibility biomarkers for breast cancer. (
  • However, most people notice the effect of circadian rhythms on their sleep patterns. (
  • Shift work with frequently changing hours, jet lag from switching time zones, certain medical conditions , or even simply choosing to stay up late one night are all things that can throw off your sleep patterns and circadian rhythm. (
  • The objective of this FOA is to understand the molecular mechanisms of alcohol-induced tissue damage that involve central and peripheral circadian rhythms, particularly their connection with metabolism and metabolic disorders. (
  • In the past two decades, major progress has been made to understand the molecular mechanisms of circadian rhythms. (
  • Along with colleagues Jeffrey C. Hall and Michael Rosbash, Dr. Young received the 2017 Nobel Prize in Physiology or Medicine for discoveries of molecular mechanisms controlling circadian rhythms. (
  • Interestingly, the circadian clock system relies upon the regulation of the critical pathways of autophagy, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) as well as proliferative mechanisms that involve the wingless pathway of Wnt/β-catenin pathway to foster cell survival during injury and block tumor cell growth. (
  • However, because of the small numbers of subjects studied, the incidence and clinical significance of circadian rhythm abnormalities among the blind has remained uncertain. (
  • Most totally blind subjects had circadian rhythm abnormalities. (
  • The high incidence of abnormal circadian rhythms in blind people underscores the importance of the light-dark cycle as an important environmental synchronizer for the human circadian system. (
  • Circadian rhythm is the internal biological clock that regulates body functions based on our wake/sleep cycle. (
  • Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. (
  • Circadian rhythm is your body's 24-hour internal clock, which regulates your sleep/wake cycle. (
  • Circadian rhythm disorders, also known as sleep-wake cycle disorders, are problems that occur when your body's internal clock, which tells you when it's time to sleep or wake, is out of sync with your environment. (
  • You can take steps to prevent circadian rhythm disorders by making healthy lifestyle changes to improve your sleep habits. (
  • If left untreated, circadian rhythm disorders may increase the risk of certain health problems or lead to workplace and road accidents. (
  • Book traversal links for What Are Circadian Rhythm Disorders? (
  • On the heels of their research statement on cancer fatigue , they've issued another on sleep and circadian disorders (SCD) in the intensive care unit . (
  • Methods: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis. (
  • Interestingly, patients with Alzheimer's disease and Parkinson's disease may suffer disease onset or progression as a result of alterations in the DNA methylation of clock genes as well as prolonged pharmacological treatment for these disorders that may lead to impairment of circadian rhythm function. (
  • Conclusion: Future targeting of the pathways of autophagy, mTOR, SIRT1, and Wnt that control mammalian circadian rhythm may hold the key for the development of novel and effective therapies against aging- related disorders, neurodegenerative disease, and tumorigenesis. (
  • Study findings provide the first evidence of altered circadian gene rhythms in brain tissue of people with depression and suggest a physical basis for many of the symptoms that depressed patients report. (
  • Dan Ford , a licensed psychologist who specializes in insomnia treatment and serves as clinical director at The Better Sleep Clinic in Auckland, New Zealand, told Healthline that these findings match up with the current understanding of how circadian rhythms work. (
  • At a recent scientific meeting, researcher Monica Federoff described new findings about lithium's effects in people with bipolar I disorder, especially regarding circadian rhythms. (
  • In this article, Axelrod and several members of his laboratory reported their findings on circadian rhythms and the results of a series of experiments on the pineal glands of rats. (
  • In our proposed studies we attempt to disentangle the mechanism leading to the toxicity of PM2.5 by testing the novel hypothesis that PM2.5 disrupts vascular circadian rhythms and that this contributes to the development of cardiometabolic disease in a new susceptibility state of circadian dyssynchrony. (
  • Scientists learn about circadian rhythms by studying humans and by using organisms with similar biological clock genes, such as fruit flies and mice. (
  • Because most biological organisms have predictable rhythms that increase and decrease in strength throughout the day, we can improve the effectiveness of medications and other interventions, and therefore treatment outcomes, by paying attention to when we time their delivery," Ford explained. (
  • Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. (
  • This Funding Opportunity Announcement (FOA) encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol-induced organ damage. (
  • The circadian rhythm is the biological "clock" that governs every living organism, including humans. (
  • On the other hand , the circadian rhythm is one of the most significant biological pathways in humans and other mammals , which is affected by light , sleep , and human activity . (
  • A study of several DSPD subjects allowed Dr. Young's laboratory to recognize a specific clock gene variant that affects behavioral, physiological, and molecular circadian rhythms of carriers under controlled laboratory conditions. (
  • The novel features of the flexible silicon jacket for µECG telemetry unraveled the biological clock and normalization of QT intervals at 26 dpa, providing the first evidence of new physiological phenomena during cardiac injury and repair as well as cardiac drug-mediated aberrant rhythms. (
  • Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. (
  • When people are completely isolated from environmental time cues, their circadian rhythms free run with a nearly 24-h cycle, generated by an internal body clock. (
  • Circadian rhythm neurons in the fruit fly brain. (
  • By analyzing the liver metabolome of mice deficient in the expression of the dopamine D2 receptor (D2R) in striatal medium spiny neurons, the researchers found profound changes in the liver circadian metabolome compared to control mice. (
  • Targeted social rhythm therapy may be useful for bipolar depression though some studies suggest that a non-targeted psychosocial or pharmacological intervention may be just as efficacious. (
  • Circadian rhythms refer to processes that occur in a 24-hour cycle like sleeping and waking. (
  • A new University of California, Irvine-led study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. (
  • The circadian clock is tightly intertwined with metabolism and relies heavily on multifaceted interactions between organ systems to maintain proper timing. (
  • Substance use leads to altered dopamine signaling followed by reprogramming of circadian gene expression and metabolism in the reward system. (
  • for the early morning light we send a signal to our body through the biological part of our "third eye" that sets our body circadian (daily) and ultradian (seasonal) clocks. (
  • UC Irvine Health researchers have helped discover that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression. (
  • Their depression improved in the direction of more "morningness," and the authors suggested that "stabilization of circadian symptoms of depression may be an essential feature of lithium's therapeutic effects in [bipolar] I patients. (
  • In rodents who were induced into a depression-like state, the CLOCK genes were dysregulated and did not correspond to normal circadian rhythms. (
  • Create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep and its impact on brain aging and the risk of AD and AD-related dementias at multiple levels (epigenetic, gene expression, proteomic, neuronal, network, systems) to identify new targets and approaches for AD prevention. (
  • We were amazed that our data revealed that clock gene rhythms varied in synchrony across six regions of normal human brain and that these rhythms were significantly disrupted in depressed patients. (
  • Although animal data provide evidence for the circadian expression of genes in brain, little has been known as to whether there is a similar rhythmicity in the human brain. (
  • The central clock in the brain uses specific biochemical and neural pathways to pass its circadian signals along to other organs, such as the liver or heart. (
  • NIA supported 24 projects through three targeted and one general funding initiative, aimed at investigating the role of sleep and circadian rhythms in brain aging and dementia. (
  • Your circadian clock is controlled by a part of your brain called the hypothalamus that responds to light . (
  • The circadian system comprises of a complex feedback network that involves interactions between the central nervous system and peripheral tissues. (
  • We discovered that the peripheral auditory system, the cochlea, is regulated by a molecular circadian clock, which opened an exceptional opportunity for understanding unique features of the auditory system that were previously unknown. (
  • thus an intact visual system may be essential for synchronization of the circadian system. (
  • Representative bioluminescence records of circadian Period 2 protein expression in cultured adult cochleae explants (A). Addition of Dexamethasone (DEX) as depicted by the arrow causes a rapid synchronization of Period 2 rhythms compared to vehicle. (
  • The lab's results are consistent with the candidate allele encoding a dominant, hyperactive transcription factor that alters sleep and circadian rhythms by lengthening the period of the circadian clock. (
  • Meanwhile, both circadian rhythm regulation and the pupil reflex only use "on" bipolar cells pathways, relying on rod bipolar cells and "on" cone bipolar cells, but not "off" cone bipolar cells. (
  • How do circadian rhythms affect health? (
  • Several are investigating health disparities linked to differences in sleep and circadian rhythms, with the goal of enabling evidence-based interventions that address sleep as a modifiable risk factor for AD/ADRD. (
  • We explain what circadian rhythm is, how it works, and explore the health benefits of maintaining it with sleep consistency. (
  • In this interactive reading experience about sleep, circadian rhythms, and health, students help a young girl answer these questions so she can convince her mom to let her stay up late for CityHacks, a cool coding club that she wants to join. (
  • Or a circadian rhythm disorder can be long-term and caused by aging, your genes, or a medical condition. (
  • To diagnose a circadian rhythm disorder, your doctor may ask about your sleep habits and may suggest a sleep study and some other diagnostic tests. (
  • Your treatment plan will depend on the type and cause of your circadian rhythm disorder. (
  • Circadian rhythm in bipolar disorder: A review of the literature. (
  • One example of a light-related circadian rhythm is sleeping at night and being awake during the day. (
  • Changes in our body and environmental factors can cause our circadian rhythms and the natural light-dark cycle to be out of sync. (
  • Light also triggers certain non-vision functions, such as controlling how much light enters the eye through the pupil (pupillary light reflex) and regulating the wake/sleep cycle (circadian rhythm). (
  • Psychosocial, pharmacological, and light-based approaches are promising avenues for treating circadian dysfunction in BD. (
  • This hypothesis is supported by our preliminary data showing that that exposure to concentrated ambient PM2.5 (CAP) alters the rhythmic expression of clock genes in the murine aorta and increases insulin resistance in mice with the disturbed light/dark cycle (circadian dyssynchrony). (
  • However, "artificial light in the last 150 years has disrupted many people's natural circadian rhythm," said Zhu. (
  • The researchers found that the circadian rhythm was synchronized by exposure to light, but otherwise operated independent of it. (
  • However, exposure to constant light, or blinding the rats altogether, significantly altered their circadian rhythms. (
  • Remarkable breakthroughs in our understanding of the cell biology that controls circadian rhythm make the circadian control system an outstanding model for studying how naturally occurring variation in DNA sequence among people can dramatically alter something as basic as sleep scheduling," says Klimecki. (
  • The circadian rhythm system orchestrates the temporal organization of many aspects of physiology. (
  • In 2017, researchers Jeffrey C. Hall, Michael Rosbash, and Michael W. Young won the prestigious Nobel Prize for their circadian rhythms research. (
  • The effects of alcohol on circadian rhythm and how alcohol's action is modulated by circadian rhythms have key implications for alcohol research. (
  • Some of the seminal research we published on DNA repair and circadian rhythms set me on the path I'm on today. (
  • The Average Teen Circadian Cycle image shows the circadian rhythm cycle of a typical teen. (
  • Circadian rhythm cycle of a typical teenager. (
  • Circadian clock genes play an important role in regulating many body rhythms over a 24-hour cycle. (
  • Resetting circadian rhythm, or in truth finding out what your natural circadian cycle really is, is easy if you have the time. (
  • Because it is adapted to the Earth's rotation, the circadian rhythm is roughly a 24-hour cycle in which the 12 hours of the night correspond to our regular sleeping pattern. (
  • live in harmony with your body's natural sleep cycle and circadian rhythms. (
  • It is widely known that changes in the circadian rhythm can alter some metabolic pathways of body cells and could affect the treatment process, particularly for metabolic diseases like T2DM. (
  • The aim of this study is to explore the importance of the circadian rhythm in the occurrence of T2DM via reviewing the metabolic pathways involved, their relationship with the circadian rhythm from two perspectives, lifestyle and molecular pathways, and their effect on T2DM pathophysiology. (
  • Does the body make and keep its own circadian rhythms? (
  • Yes, natural factors in your body produce circadian rhythms. (
  • Researchers say that since circadian rhythms dictate cellular function within the body and because cancer spreads via cells, the spread of cancer differs throughout the day. (
  • Lithium holds potential for addressing circadian dysfunction in BD. (
  • Only those who were classified as good responders to lithium treatment showed improvement in circadian symptoms. (
  • A synchronized dance of proteins and enzymes within our cells can explain our circadian rhythm, but might they also help explain why we age? (
  • The synchronized dance of proteins and enzymes within our cells that help articulate our circadian rhythms can explain both of these relatively common experiences. (
  • However, there are critical gaps in knowledge of how circadian rhythms affect immune function in the cochlea. (
  • A robust molecular circadian clock machinery including the core clock genes Per1, Per2, Bmal1, and Rev-Erb-alpha , was identified in the cochlea. (
  • The researchers also disrupted the sleep rhythms of mice in another study and found that doing so led to a buildup of amyloid plaque in their brains. (
  • Some blind subjects suffered recurrent insomnia and daytime sleepiness that were maximal when the internal rhythms were out of phase with the preferred sleep times. (
  • Experts interviewed by Healthline say that the data is in line with our understanding of the role of circadian rhythms in human biology. (
  • Additionally, circadian rhythms tend to change and evolve with age. (
  • Circadian Rhythm was formed in the summer of 2012, It was then that Craig and John decided that it was time to start writing some of their own tunes again and that Circadian Rhythm should be born. (
  • The horizontal axis shows the sampling Circadian Time (CT) across 24 hours. (
  • In CRSD a person's circadian system makes it difficult for them to sleep at the time they wish to schedule. (
  • time of day (because of the heat and circadian rhythms) and day of week (depending on the workers predisposition and accumulation of fatigue). (
  • These impacts have been demonstrated in a variety of studies and led to the development of approaches such as time -restricted feeding , chronotherapy ( time -specific therapies ), and circadian molecule stabilizers . (