Sleep Disorders, Circadian Rhythm
Period Circadian Proteins
Circadian Rhythm Signaling Peptides and Proteins
ARNTL Transcription Factors
Jet Lag Syndrome
Nuclear Receptor Subfamily 1, Group D, Member 1
Casein Kinase Iepsilon
Seasonal Affective Disorder
Work Schedule Tolerance
Nuclear Receptor Subfamily 1, Group F, Member 1
Gene Expression Regulation
Dorsomedial Hypothalamic Nucleus
Photoreceptor Cells, Invertebrate
Basic Helix-Loop-Helix Transcription Factors
Ocular Physiological Phenomena
Casein Kinase Idelta
Vasoactive Intestinal Peptide
Body Temperature Regulation
Casein Kinase I
Cell Cycle Proteins
Animals, Genetically Modified
Receptor, Melatonin, MT2
Gene Expression Regulation, Plant
Analysis of Variance
Effects of dispersed recreational activities on the microbiological quality of forest surface water. (1/9125)The microbiological quality of forest surface waters in the Greenwater River watershed was examined to investigate the influence of heavy motorized camping in an area with no sanitary facilities. Indicator densities increased during weekend human-use periods when compared to weekdays. Increases in indicator densities were also noted downstream from heavily used camping areas when compared to upstream sites. Seasonal, weekly, and diurnal fluctuations in indicator densities were observed. This study suggests that potential health hazards exist in this watershed during periods of human use. (+info)
High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (2/9125)Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability. (+info)
Alteration of circadian time structure of blood pressure caused by night shift schedule. (3/9125)The effects of night shift schedules on circadian time structure of blood pressure were studied in seven healthy young subjects by continuous monitoring of blood pressure every 30 min for 72 h. In the control experiment, subjects were instructed to sleep at regular times with the light off at 00.00 h and the light on at 07.00 h. In the shift experiment, they were instructed to go to bed at 06.00 h and wake up at 11.00 h. The circadian rhythm of blood pressure rapidly phase delayed by 3.5 h in the second night shift day as a group phenomenon. Individual differences in changes in power spectral patterns of blood pressure were found in the night shift schedule. Ultradian rhythmicity of blood pressure was more pronounced in three subjects, whereas the circadian rhythmicity was maintained in four subjects. These findings held when the adaptation to shift work was taken into account. (+info)
Circadian variation in the expression of cell-cycle proteins in human oral epithelium. (4/9125)At the tissue level, there is experimental and clinical data to suggest a cytokinetic coordination of the cell cycle with a greater proportion of cycling cells entering S-phase and mitosis at specific times of the day. The association of certain cell-cycle proteins with defined events in the cell cycle is well established and may be used to study the timing of cell-cycle phases over 24 hours. In this study oral mucosal biopsies were obtained from six normal human volunteers at 4-hour intervals, six times over 24 hours. Using immunohistochemistry, the number of positive cells expressing the proteins p53, cyclin-E, cyclin-A, cyclin-B1, and Ki-67 was determined for each biopsy and expressed as the number of positive cells per mm of basement membrane. We found a statistically significant circadian variation in the nuclear expression of all of these proteins with the high point of expression for p53 at 10:56 hours, cyclin-E at 14:59 hours, cyclin-A at 16:09 hours, cyclin-B1 at 21:13 hours, and Ki-67 at 02:50 hours. The circadian variation in the nuclear expression of cyclins-E (G1/S phase), -A (G2-phase), and -B1 (M-phase) with a normal physiological progression over time suggests a statistically significant circadian variation in oral epithelial cell proliferation. The finding of a circadian variation in the nuclear expression of p53 protein corresponding to late G1 is novel. This information has clinical implications regarding the timing of chemotherapy and radiotherapy. (+info)
The biological clock of very premature primate infants is responsive to light. (5/9125)Each year more than 250,000 infants in the United States are exposed to artificial lighting in hospital nurseries with little consideration given to environmental lighting cycles. Essential in determining whether environmental lighting cycles need to be considered in hospital nurseries is identifying when the infant's endogenous circadian clock becomes responsive to light. Using a non-human primate model of the developing human, we examined when the circadian clock, located in the hypothalamic suprachiasmatic nuclei (SCN), becomes responsive to light. Preterm infant baboons of different ages were exposed to light (5,000 lux) at night, and then changes in SCN metabolic activity and gene expression were assessed. After exposure to bright light at night, robust increases in SCN metabolic activity and gene expression were seen at ages that were equivalent to human infants at 24 weeks after conception. These data provide direct evidence that the biological clock of very premature primate infants is responsive to light. (+info)
Effects of different light intensities during the daytime on circadian rhythm of core temperature in humans. (6/9125)The present study was to determine the effects of bright light exposure during the daytime on core temperature rhythm. Eight female students participated as subjects. They were exposed to bright light of 5000 lux or dim light of 200 lux for 13 hours (06:30-19:30) for two consecutive days. Except the sleep period (22:30-06:30) and during the bright light exposure, light intensity was controlled at 200 lux. Rectal temperature data were collected every 10 min throughout the whole experimental period. The mean level of rectal temperature was not significantly different between the bright and the dim light conditions. However, the evening fall and the morning rise of rectal temperature were significantly greater in the bright light conditions on Day 2 compared to the dim. Furthermore, cosinor analysis showed that the acrophase of rectal temperature rhythm was earlier on Day 2 in the bright light conditions than the dim, and was significantly delayed on Day 2 compared to Day 1 in the dim light conditions. These results suggest that low intensity during the daytime for two consecutive days may induce a phase delay of core temperature rhythm rather than the bright light exposure at least in normally entrained female subjects. (+info)
Ambulatory blood pressure monitoring and progression in patients with IgA nephropathy. (7/9125)BACKGROUND: Hypertension is a recognized marker of poor prognosis in IgA nephropathy. METHODS: The present study investigated the prevalence of white-coat hypertension, the diurnal rhythm of blood pressure (BP), the effectiveness of antihypertensive drug therapy, and the effect of the above on the progression of the kidney disease in IgA nephropathy. One hundred twenty-six IgA nephropathy patients were selected consecutively for 24-h ambulatory blood pressure monitoring (ABPM). Fifty-five patients were normotensive and 71 were treated hypertensives. Their antihypertensive drugs were angiotensin-converting enzyme inhibitors (ACEI) alone or in combination with calcium-channel blockers (CCB). RESULTS: The mean night-time BP of normotensives (108+/-9/67+/-6 mmHg) was significantly lower than their day-time BP (125+/-8/82+/-7 mmHg, P<0.05). There was no significant difference between the mean day-time and night-time BP in hypertensive patients (125+/-9/82+/-7 mmHg vs 128+/-10/85+/-9 mmHg). The circadian variation of BP was preserved ('dippers') in 82% of the normotensive and 7% of the hypertensive patients (P<0.001). There were 10 'white-coat hypertensives' among the patients classified as normotensives with ABPM (mean office blood pressure 149+/-7/96+/-8 mmHg, 24-h blood pressure 127+/-6/83+/-5 mmHg, P<0.05) and 14 among treated hypertensives (mean office BP 152+/-8/98+/-6 mmHg, 24-h BP 130+/-4/85+/-8 mmHg, P<0.05). There was no difference in mean day-time BP among normotensive and treated hypertensive patients (125+/-8/81+/-5 mmHg vs 128+/-10/85+/-9 mmHg). Hypertensives had significantly higher night-time BP (125+/-9/85+/-9 mmHg) than normotensives (108+/-9/67+/-6 mmHg, P<0.001). There was no difference in serum creatinine levels among the different groups at the time of the ABPM. However, thirty-six+/-4.1 months after the ABPM, hypertensive patients (n=52) had higher serum creatinine levels (124+/-32 micromol/l) than at the time of the ABPM (101+/-28 micromol/l). The serum creatinine of normotensive patients (n=43) did not change during the follow-up period. 'Non-dipper' normotensives (n=10) had significantly higher serum creatinine levels at the end of the follow-up period than at its beginning (106+/-17 micromol/l vs 89+/-18 micromol/l, P<0.05). There was no increase in serum creatinine of 'dipper' normotensives. The mean serum creatinine of 'white-coat hypertensives' was significantly higher at the end of the study period than at its beginning. CONCLUSIONS: There is no diurnal blood pressure variation in most of the hypertensive IgA nephropathy patients. ACEI and CCB treatment have better effect on day-time than night-time hypertension. The lack of the circadian rhythm and 'white-coat hypertension' seems to accelerate the progression of IgA nephropathy. (+info)
Diurnal variation and age differences in the biochemical markers of bone turnover in horses. (8/9125)Biochemical markers of bone turnover provide sensitive, rapid, and noninvasive monitoring of bone resorption and formation. Serum concentrations of osteocalcin (OC) reflect rates of bone formation, and urinary concentrations of the pyridinium crosslinks pyridinoline (Pyd) and deoxypyridinoline (Dpd) are specific and sensitive markers of bone resorption. These markers are age-dependent and are used to detect and monitor changes in the rates of bone turnover in a variety of orthopedic diseases in humans and may prove to have similar application in horses. This study examined age differences and diurnal variation in OC, Pyd, and Dpd in eight adult geldings and seven weanling colts. Blood and urine were collected at regular intervals over 24 h. Serum OC and cortisol, and urinary Pyd and Dpd were analyzed. Mean 24-h concentrations of cortisol and all three markers were higher (P<.003) in weanlings than adults. Significant 24-h variation was observed in adult gelding OC, Pyd, and Dpd concentrations (P< .02). Adult OC concentrations were highest between 2400 and 0900; Pyd and Dpd peaked between 0200 and 0800. Similar patterns of bone turnover were observed in weanling values, but they were not significant (P>.17) owing to greater variability between individuals. Cortisol secretion varied (P<.001) over 24 h in both adults and weanlings and, thus, did not seem to be responsible for greater variability in markers of bone turnover between weanlings. These data demonstrate that diurnal rhythms exist for serum OC and urinary Pyd and Dpd in adult horses, as reported in humans, and that sample timing is an important consideration in future equine studies using these markers. (+info)
Circadian rhythm is the internal biological clock that regulates the sleep-wake cycle. It is controlled by a small group of cells in the brain called the suprachiasmatic nucleus (SCN), which responds to light and dark signals from the environment to synchronize our bodily functions with the 24-hour day-night cycle.
Sleep disorders can be caused by disruptions to the body's natural circadian rhythm, such as shift work sleep disorder, jet lag, or exposure to artificial light at night. These disruptions can lead to difficulty falling asleep, staying asleep, or experiencing poor quality sleep, which can have negative effects on physical and mental health.
Treatment for sleep disorders often involves a combination of lifestyle changes, such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment. Medications or other therapies may also be prescribed to help regulate sleep patterns or manage symptoms.
In addition to disrupting circadian rhythm, sleep disorders can also have other causes, such as stress, anxiety, depression, or certain medical conditions like sleep apnea. It is important to seek medical advice if you are experiencing persistent sleep problems or difficulty functioning during the day due to poor sleep.
Chronobiology disorders can result when the body's natural circadian rhythm is disrupted or altered, leading to problems with sleep timing, duration, and quality, as well as other physiological and behavioral issues. Examples of chronobiology disorders include:
1. Circadian rhythm sleep disorders: These are conditions that affect the body's natural sleep-wake cycle, such as delayed sleep phase syndrome (DSPS) and advanced sleep phase disorder (ASPD).
2. Jet lag: This occurs when traveling across time zones, causing a mismatch between the body's internal clock and the local environment.
3. Shift work sleep disorder: This affects people who work outside of traditional daytime hours and experience difficulty adjusting to irregular sleep schedules.
4. Irregular sleep-wake patterns: This can be caused by factors such as working night shifts, rotating shifts, or having an irregular sleep schedule.
5. Sleep apnea: A sleep disorder in which a person's breathing is interrupted during sleep, often causing them to wake up frequently throughout the night.
6. Insomnia: Difficulty falling asleep or staying asleep, often caused by stress, anxiety, or other factors that disrupt the body's natural sleep-wake cycle.
7. Depression: A mood disorder that can affect the body's circadian rhythm, leading to changes in sleep patterns and other physiological functions.
8. Bipolar disorder: A mood disorder that can cause changes in sleep patterns, energy levels, and other physiological functions.
9. Seasonal affective disorder (SAD): A type of depression that occurs during the winter months when there is less sunlight.
10. Hypersomnia: Excessive sleepiness or prolonged periods of sleep, often caused by factors such as medication side effects, sleep disorders, or other medical conditions.
It's important to note that these are just a few examples of the many potential causes of irregular sleep patterns, and there may be other underlying factors that contribute to this symptom. If you are experiencing persistent changes in your sleep patterns, it is important to speak with a healthcare professional to determine the cause and find appropriate treatment.
Jet lag is also known as desynchronosis or traveler's exhaustion. It occurs when our body's natural sleep-wake cycle, regulated by an internal biological clock, is disrupted due to rapid travel across different time zones. The circadian rhythm, which controls the release of hormones and other physiological processes, takes time to adjust to the new time zone, leading to symptoms such as:
* Insomnia or excessive sleepiness
* Confusion and disorientation
* Digestive problems such as constipation or diarrhea
* Mood disturbances like irritability or depression
The severity of jet lag can vary depending on the number of time zones crossed, with longer flights causing more significant disruptions to our internal clock. Additionally, some people may be more sensitive to jet lag than others due to individual differences in sleep patterns and circadian rhythms.
There are several strategies that can help alleviate the symptoms of jet lag, such as:
* Gradually adjusting sleep schedules before traveling
* Avoiding caffeine and alcohol, which can disrupt sleep patterns further
* Exposure to sunlight or bright artificial light to help regulate our circadian rhythm
* Taking melatonin supplements to help reset our internal clock.
While jet lag is a temporary condition that usually resolves within a few days, it can have significant impacts on our daily activities and overall well-being during the adjustment period. Therefore, understanding the definition of jet lag syndrome and its causes is essential for managing this common travel-related disorder.
SAD is thought to be caused by the lack of sunlight during the winter months, which can disrupt the body's internal clock and affect the production of neurotransmitters such as serotonin and melatonin. This can lead to feelings of sadness, hopelessness, and a loss of interest in activities that were once enjoyed.
Treatment for SAD may include light therapy, which involves exposure to bright artificial light that mimics natural sunlight, as well as other forms of therapy such as cognitive-behavioral therapy (CBT) and medication. Lifestyle changes such as regular exercise, social support, and improving sleep habits can also be helpful in managing symptoms of SAD.
The effects of sleep deprivation can be severe and long-lasting, including:
1. Impaired cognitive function: Sleep deprivation can affect attention, memory, and decision-making skills, making it more difficult to perform daily tasks and make sound judgments.
2. Emotional distress: Lack of sleep can lead to irritability, anxiety, and depression, which can negatively impact relationships and overall well-being.
3. Physical health problems: Chronic sleep deprivation has been linked to an increased risk of obesity, diabetes, cardiovascular disease, and immune system dysfunction.
4. Impaired motor function: Sleep deprivation can cause coordination problems, clumsiness, and a higher risk of accidents, particularly in activities that require attention and quick reflexes (e.g., driving).
5. Premature aging: Chronic sleep deprivation can accelerate the aging process and reduce the body's ability to repair and regenerate cells.
6. Reduced productivity and performance: Sleep deprivation can lead to decreased productivity, poor work quality, and increased absenteeism, which can negatively impact career advancement and financial stability.
7. Increased risk of accidents and injuries: Drowsy driving and workplace accidents are common consequences of sleep deprivation, which can result in fatalities and long-term disabilities.
8. Weakened immune system: Sleep deprivation can weaken the immune system, making it more difficult to fight off infections and diseases.
9. Negative impact on relationships: Sleep deprivation can lead to mood swings, irritability, and difficulty interacting with others, which can strain personal and professional relationships.
10. Increased risk of mental health disorders: Chronic sleep deprivation has been linked to an increased risk of developing anxiety, depression, and other mental health disorders.
To avoid these negative consequences, it's essential to prioritize sleep and make it a critical component of your daily routine. Establishing a consistent sleep schedule, creating a sleep-conducive environment, and practicing relaxation techniques can help improve sleep quality and duration. Additionally, avoiding stimulating activities before bedtime, limiting exposure to electronic screens, and seeking professional help if sleep problems persist can contribute to better overall health and well-being.
People with dyssomnia may experience symptoms such as:
* Difficulty falling asleep
* Waking frequently during the night
* Waking too early in the morning
* Feeling groggy or disoriented upon waking
* Poor quality sleep
Dyssomnia can be caused by a variety of factors, including stress, anxiety, depression, chronic pain, sleep disorders, and certain medications. Treatment options for dyssomnia may include lifestyle changes, such as establishing a regular sleep schedule and avoiding caffeine and alcohol before bedtime, as well as cognitive behavioral therapy, relaxation techniques, and in some cases, medication.
It is important to note that dyssomnia is not a specific sleep disorder, but rather a term used to describe a group of related conditions. If you are experiencing difficulty sleeping or poor quality sleep, it is important to speak with a healthcare professional for proper diagnosis and treatment.
There are several risk factors for developing AF, including:
1. Age: The risk of developing AF increases with age, with the majority of cases occurring in people over the age of 65.
2. Hypertension (high blood pressure): High blood pressure can damage the heart and increase the risk of developing AF.
3. Heart disease: People with heart disease, such as coronary artery disease or heart failure, are at higher risk of developing AF.
4. Diabetes mellitus: Diabetes can increase the risk of developing AF.
5. Sleep apnea: Sleep apnea can increase the risk of developing AF.
6. Certain medications: Certain medications, such as thyroid medications and asthma medications, can increase the risk of developing AF.
7. Alcohol consumption: Excessive alcohol consumption has been linked to an increased risk of developing AF.
8. Smoking: Smoking is a risk factor for many cardiovascular conditions, including AF.
9. Obesity: Obesity is a risk factor for many cardiovascular conditions, including AF.
Symptoms of AF can include:
1. Palpitations (rapid or irregular heartbeat)
2. Shortness of breath
4. Dizziness or lightheadedness
5. Chest pain or discomfort
AF can be diagnosed with the help of several tests, including:
1. Electrocardiogram (ECG): This is a non-invasive test that measures the electrical activity of the heart.
2. Holter monitor: This is a portable device that records the heart's rhythm over a 24-hour period.
3. Event monitor: This is a portable device that records the heart's rhythm over a longer period of time, usually 1-2 weeks.
4. Echocardiogram: This is an imaging test that uses sound waves to create pictures of the heart.
5. Cardiac MRI: This is an imaging test that uses magnetic fields and radio waves to create detailed pictures of the heart.
Treatment for AF depends on the underlying cause and may include medications, such as:
1. Beta blockers: These medications slow the heart rate and reduce the force of the heart's contractions.
2. Antiarrhythmics: These medications help regulate the heart's rhythm.
3. Blood thinners: These medications prevent blood clots from forming and can help reduce the risk of stroke.
4. Calcium channel blockers: These medications slow the entry of calcium into the heart muscle cells, which can help slow the heart rate and reduce the force of the heart's contractions.
In some cases, catheter ablation may be recommended to destroy the abnormal electrical pathway causing AF. This is a minimally invasive procedure that involves inserting a catheter through a vein in the leg and guiding it to the heart using x-ray imaging. Once the catheter is in place, energy is applied to the abnormal electrical pathway to destroy it and restore a normal heart rhythm.
It's important to note that AF can increase the risk of stroke, so anticoagulation therapy may be recommended to reduce this risk. This can include medications such as warfarin or aspirin, or in some cases, implantable devices such as a left atrial appendage closure device.
In conclusion, atrial fibrillation is a common heart rhythm disorder that can increase the risk of stroke and heart failure. Treatment options depend on the underlying cause and may include medications, cardioversion, catheter ablation, or anticoagulation therapy. It's important to work closely with a healthcare provider to determine the best course of treatment for AF.
1. Insomnia: difficulty falling asleep or staying asleep
2. Sleep apnea: pauses in breathing during sleep
3. Narcolepsy: excessive daytime sleepiness and sudden attacks of sleep
4. Restless leg syndrome: uncomfortable sensations in the legs during sleep
5. Periodic limb movement disorder: involuntary movements of the legs or arms during sleep
6. Sleepwalking: walking or performing other activities during sleep
7. Sleep terrors: intense fear or anxiety during sleep
8. Sleep paralysis: temporary inability to move or speak during sleep
9. REM sleep behavior disorder: acting out dreams during sleep
10. Circadian rhythm disorders: disruptions to the body's internal clock, leading to irregular sleep patterns.
Sleep disorders can be caused by a variety of factors, such as stress, anxiety, certain medications, sleep deprivation, and underlying medical conditions like chronic pain or sleep apnea. Treatment for sleep disorders may include lifestyle changes (such as establishing a regular sleep schedule, avoiding caffeine and alcohol before bedtime, and creating a relaxing sleep environment), medications, and behavioral therapies (such as cognitive-behavioral therapy for insomnia). In some cases, surgery or other medical interventions may be necessary.
It is important to seek medical attention if you suspect that you or someone you know may have a sleep disorder, as untreated sleep disorders can lead to serious health problems, such as cardiovascular disease, obesity, and depression. A healthcare professional can help diagnose the specific sleep disorder and develop an appropriate treatment plan.
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- Several hundred genes in each of six brain regions displayed rhythmic patterns of expression over the 24-hour cycle, including many genes essential to the body's circadian machinery. (scienceblog.com)
- A new review paper reports that cancer is intrinsically linked to the body's circadian rhythms. (healthline.com)
- Staying at least broadly in sync with such rhythms helps the body's circadian-dependent systems to strike the right balance and better achieve homeostasis, or the maintenance of well-functioning cellular processes that contribute to overall health. (healthline.com)
- Groundbreaking research at the Yale School of Public Health has shown that changes in a gene responsible for regulating the body's circadian rhythm increase the risk of breast cancer in women. (yalescientific.org)
- Aircrew members may experience circadian rhythm disruption (specifically "jet lag") as they work. (cdc.gov)
- Here you can learn more about circadian rhythm disruption, why it occurs, possible health effects, and how crewmembers can reduce the effects of circadian disruption. (cdc.gov)
- Why might aircrew be concerned about circadian rhythm disruption? (cdc.gov)
- Although travelers who get circadian disruption after a single flight recover after 1-2 weeks, many crewmembers are continually exposed and show evidence of chronic circadian rhythm disruption. (cdc.gov)
- Some crewmembers may have higher exposure to circadian disruption than most of their coworkers and thus may be at greater risk for possible health effects. (cdc.gov)
- A study we completed found that travel across time zones and work during a flight attendant's normal sleep hours were both linked to chronic circadian disruption in a group of flight attendants. (cdc.gov)
- The World Health Organization says that shift work (including the kind of circadian disruption that aircrew encounter) probably causes cancer. (cdc.gov)
- We don't know what causes most health problems that may be linked to circadian disruption, including some types of cancer as well as reproductive health issues like miscarriage and birth defects. (cdc.gov)
- If you experience circadian disruption and have these health problems, we can't tell if the problem was caused by your work conditions or if it was caused by something else. (cdc.gov)
- We don't know how much circadian disruption is safe for every person. (cdc.gov)
- Bidding for a flight schedule to reduce circadian disruption exposures is complicated, because reducing one exposure may increase another. (cdc.gov)
- These are flight conditions that tend to increase the amount of circadian disruption the aircrew is exposed to. (cdc.gov)
- If you are pregnant or planning a pregnancy, it is important to consider your work exposures, including circadian disruption. (cdc.gov)
- Circadian rhythm disruption has been linked to sleep problems, obesity, and other health issues. (nih.gov)
- Launch at least 12 new projects focused on understanding the short-term and long-term consequences of disrupted/optimized circadian rhythms and sleep on brain aging and dementia and the mechanistic links between sleep/circadian disruption and AD and AD-related dementias to identify new targets and approaches for AD prevention. (nih.gov)
- Circadian disruption and breast cancer: from melatonin to clock genes. (yalescientific.org)
- Circadian Rhythms are endogenous self-sustaining oscillations that organize the timing of biological systems to optimize physiology and behavior, and health. (nih.gov)
- The findings provide clues for potential new classes of compounds to rapidly treat depression that may reset abnormal clock genes and normalize circadian rhythms," said Dr. William Bunney, the study's senior author, and Distinguished Professor of Psychiatry & Human Behavior at UC Irvine. (scienceblog.com)
- Recent studies have also revealed that circadian system affects metabolic homeostasis while metabolic pathways feed back into the regulation of circadian system and modulate many physiological processes and behavior. (nih.gov)
- However, many other biological functions such as behavior, metabolic function, cardiovascular, endocrine, digestive and immune systems are under the control of the circadian system. (ki.se)
- These oscillations are autonomously generated, are found in most tissues, and establish rhythms in physiology and behavior. (nih.gov)
- New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. (eurekaselect.com)
- The aim of the work was to analyze comparatively two measures of stress in girls and teenagers with diagnosis of Turner's syndrome, their stress perception across the Questionnaire for school stress and the circadian cortisol slope determined by salivary cortisol. (bvsalud.org)
- circadian cortisol slope. (bvsalud.org)
- These clock genes regulate 24-hour circadian rhythms affecting hormonal, body temperature, sleep and behavioral patterns. (scienceblog.com)
- Circadian rhythms are our internal body clocks that regulate our sleep patterns and other functions. (healthline.com)
- Using RNAseq we recently identified 7211 genes (49%) in the cochlea that have circadian expression and a large proportion of these regulate cell signaling, hormone secretion, and inflammation 4 . (ki.se)
- This mechanism is conserved within the animal kingdom: similar clock genes regulate patterns of sleep and other rhythms in humans. (nih.gov)
- Surprisingly, some scientists who delve into this area of research now believe similar rhythms and patterns might regulate aging. (medicaldaily.com)
- Animals and plants have biological clocks that help to regulate circadian cycles, seasonal rhythms, growth, development, and sexual maturity," J.J. Mitteldorf wrote in a recent article . (medicaldaily.com)
- Biological clocks are organisms' natural timing devices, regulating the cycle of circadian rhythms. (nih.gov)
- Circadian rhythms are driven by the circadian clock machinery (biological clocks) to ensure that the organism anticipates and adapts to temporal changes in the environment. (ki.se)
- An NIH-funded team has some new clues based on evidence showing how a molecular "switch" wired into the biological clocks of extreme early risers leads them to operate on a daily cycle of about 20 hours instead of a full 24-hour, or circadian (Latin for "about a day"), cycle . (nih.gov)
- Your internal clock, called a circadian clock, cycles about every 24 hours. (nih.gov)
- These repeating 24-hour cycles are called the circadian rhythm. (nih.gov)
- A study recently published in the journal JAMA Neurology found that adults with healthy memories who had disrupted circadian rhythms - also known as sleep cycles - had protein buildups of a substance called amyloid plaque, which can serve as an early sign of Alzheimer's. (businessinsider.com)
- The word "circadian" is based on the Latin terms for "around" (circa) and "day" (diem), so your "around-the-day" rhythm dictates the cycles your body goes through-most notably when you wake up and fall asleep. (whoop.com)
- Exposing yourself to natural light in the morning and avoiding screens and other sources of artificial light in the evening prior to bed will help align your sleep cycles and reinforce your circadian rhythm (regular light and dark times are a key factor as well). (whoop.com)
- Background: The mammalian circadian clock and its associated clock genes are increasingly been recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. (eurekaselect.com)
Genes that control2
- Dr. Young's laboratory has identified genes that control the circadian rhythms of Drosophila. (nih.gov)
- By studying blood samples from a case-control study of breast cancer as well as the MCF7 breast cancer cell line, Zhu and his lab were able to show that both genetic and epigenetic changes in the CLOCK gene , one of the nine core genes that control our circadian rhythm, can serve as susceptibility biomarkers for breast cancer. (yalescientific.org)
- However, most people notice the effect of circadian rhythms on their sleep patterns. (nih.gov)
- Shift work with frequently changing hours, jet lag from switching time zones, certain medical conditions , or even simply choosing to stay up late one night are all things that can throw off your sleep patterns and circadian rhythm. (whoop.com)
- The objective of this FOA is to understand the molecular mechanisms of alcohol-induced tissue damage that involve central and peripheral circadian rhythms, particularly their connection with metabolism and metabolic disorders. (nih.gov)
- In the past two decades, major progress has been made to understand the molecular mechanisms of circadian rhythms. (nih.gov)
- Along with colleagues Jeffrey C. Hall and Michael Rosbash, Dr. Young received the 2017 Nobel Prize in Physiology or Medicine for discoveries of molecular mechanisms controlling circadian rhythms. (nih.gov)
- Interestingly, the circadian clock system relies upon the regulation of the critical pathways of autophagy, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) as well as proliferative mechanisms that involve the wingless pathway of Wnt/β-catenin pathway to foster cell survival during injury and block tumor cell growth. (eurekaselect.com)
- The high incidence of abnormal circadian rhythms in blind people underscores the importance of the light-dark cycle as an important environmental synchronizer for the human circadian system. (nih.gov)
- Circadian rhythm is the internal biological clock that regulates body functions based on our wake/sleep cycle. (cdc.gov)
- Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. (nih.gov)
- Circadian rhythm is your body's 24-hour internal clock, which regulates your sleep/wake cycle. (whoop.com)
- Circadian rhythm disorders, also known as sleep-wake cycle disorders, are problems that occur when your body's internal clock, which tells you when it's time to sleep or wake, is out of sync with your environment. (nih.gov)
- You can take steps to prevent circadian rhythm disorders by making healthy lifestyle changes to improve your sleep habits. (nih.gov)
- If left untreated, circadian rhythm disorders may increase the risk of certain health problems or lead to workplace and road accidents. (nih.gov)
- Book traversal links for What Are Circadian Rhythm Disorders? (nih.gov)
- On the heels of their research statement on cancer fatigue , they've issued another on sleep and circadian disorders (SCD) in the intensive care unit . (medscape.com)
- Methods: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis. (eurekaselect.com)
- Interestingly, patients with Alzheimer's disease and Parkinson's disease may suffer disease onset or progression as a result of alterations in the DNA methylation of clock genes as well as prolonged pharmacological treatment for these disorders that may lead to impairment of circadian rhythm function. (eurekaselect.com)
- Conclusion: Future targeting of the pathways of autophagy, mTOR, SIRT1, and Wnt that control mammalian circadian rhythm may hold the key for the development of novel and effective therapies against aging- related disorders, neurodegenerative disease, and tumorigenesis. (eurekaselect.com)
- Study findings provide the first evidence of altered circadian gene rhythms in brain tissue of people with depression and suggest a physical basis for many of the symptoms that depressed patients report. (scienceblog.com)
- Dan Ford , a licensed psychologist who specializes in insomnia treatment and serves as clinical director at The Better Sleep Clinic in Auckland, New Zealand, told Healthline that these findings match up with the current understanding of how circadian rhythms work. (healthline.com)
- At a recent scientific meeting, researcher Monica Federoff described new findings about lithium's effects in people with bipolar I disorder, especially regarding circadian rhythms. (bipolarnews.org)
- In this article, Axelrod and several members of his laboratory reported their findings on circadian rhythms and the results of a series of experiments on the pineal glands of rats. (nih.gov)
- In our proposed studies we attempt to disentangle the mechanism leading to the toxicity of PM2.5 by testing the novel hypothesis that PM2.5 disrupts vascular circadian rhythms and that this contributes to the development of cardiometabolic disease in a new susceptibility state of circadian dyssynchrony. (nih.gov)
- Scientists learn about circadian rhythms by studying humans and by using organisms with similar biological clock genes, such as fruit flies and mice. (nih.gov)
- Because most biological organisms have predictable rhythms that increase and decrease in strength throughout the day, we can improve the effectiveness of medications and other interventions, and therefore treatment outcomes, by paying attention to when we time their delivery," Ford explained. (healthline.com)
- Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. (nih.gov)
- This Funding Opportunity Announcement (FOA) encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol-induced organ damage. (nih.gov)
- The circadian rhythm is the biological "clock" that governs every living organism, including humans. (yalescientific.org)
- On the other hand , the circadian rhythm is one of the most significant biological pathways in humans and other mammals , which is affected by light , sleep , and human activity . (bvsalud.org)
- A study of several DSPD subjects allowed Dr. Young's laboratory to recognize a specific clock gene variant that affects behavioral, physiological, and molecular circadian rhythms of carriers under controlled laboratory conditions. (nih.gov)
- The novel features of the flexible silicon jacket for µECG telemetry unraveled the biological clock and normalization of QT intervals at 26 dpa, providing the first evidence of new physiological phenomena during cardiac injury and repair as well as cardiac drug-mediated aberrant rhythms. (caltech.edu)
- Circadian rhythms are physical, mental, and behavioral changes that follow a 24-hour cycle. (nih.gov)
- When people are completely isolated from environmental time cues, their circadian rhythms free run with a nearly 24-h cycle, generated by an internal body clock. (nih.gov)
- Circadian rhythm neurons in the fruit fly brain. (nih.gov)
- By analyzing the liver metabolome of mice deficient in the expression of the dopamine D2 receptor (D2R) in striatal medium spiny neurons, the researchers found profound changes in the liver circadian metabolome compared to control mice. (worldhealth.net)
- Targeted social rhythm therapy may be useful for bipolar depression though some studies suggest that a non-targeted psychosocial or pharmacological intervention may be just as efficacious. (nih.gov)
- Circadian rhythms refer to processes that occur in a 24-hour cycle like sleeping and waking. (nih.gov)
- A new University of California, Irvine-led study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. (worldhealth.net)
- The circadian clock is tightly intertwined with metabolism and relies heavily on multifaceted interactions between organ systems to maintain proper timing. (worldhealth.net)
- Substance use leads to altered dopamine signaling followed by reprogramming of circadian gene expression and metabolism in the reward system. (worldhealth.net)
- for the early morning light we send a signal to our body through the biological part of our "third eye" that sets our body circadian (daily) and ultradian (seasonal) clocks. (msia.org)
- UC Irvine Health researchers have helped discover that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression. (scienceblog.com)
- Their depression improved in the direction of more "morningness," and the authors suggested that "stabilization of circadian symptoms of depression may be an essential feature of lithium's therapeutic effects in [bipolar] I patients. (bipolarnews.org)
- In rodents who were induced into a depression-like state, the CLOCK genes were dysregulated and did not correspond to normal circadian rhythms. (bipolarnews.org)
- Create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep and its impact on brain aging and the risk of AD and AD-related dementias at multiple levels (epigenetic, gene expression, proteomic, neuronal, network, systems) to identify new targets and approaches for AD prevention. (nih.gov)
- We were amazed that our data revealed that clock gene rhythms varied in synchrony across six regions of normal human brain and that these rhythms were significantly disrupted in depressed patients. (scienceblog.com)
- Although animal data provide evidence for the circadian expression of genes in brain, little has been known as to whether there is a similar rhythmicity in the human brain. (scienceblog.com)
- The central clock in the brain uses specific biochemical and neural pathways to pass its circadian signals along to other organs, such as the liver or heart. (nih.gov)
- NIA supported 24 projects through three targeted and one general funding initiative, aimed at investigating the role of sleep and circadian rhythms in brain aging and dementia. (nih.gov)
- Your circadian clock is controlled by a part of your brain called the hypothalamus that responds to light . (whoop.com)
- The circadian system comprises of a complex feedback network that involves interactions between the central nervous system and peripheral tissues. (nih.gov)
- We discovered that the peripheral auditory system, the cochlea, is regulated by a molecular circadian clock, which opened an exceptional opportunity for understanding unique features of the auditory system that were previously unknown. (ki.se)
- thus an intact visual system may be essential for synchronization of the circadian system. (nih.gov)
- Representative bioluminescence records of circadian Period 2 protein expression in cultured adult cochleae explants (A). Addition of Dexamethasone (DEX) as depicted by the arrow causes a rapid synchronization of Period 2 rhythms compared to vehicle. (ki.se)
- The lab's results are consistent with the candidate allele encoding a dominant, hyperactive transcription factor that alters sleep and circadian rhythms by lengthening the period of the circadian clock. (nih.gov)
- Meanwhile, both circadian rhythm regulation and the pupil reflex only use "on" bipolar cells pathways, relying on rod bipolar cells and "on" cone bipolar cells, but not "off" cone bipolar cells. (nih.gov)
- How do circadian rhythms affect health? (nih.gov)
- Several are investigating health disparities linked to differences in sleep and circadian rhythms, with the goal of enabling evidence-based interventions that address sleep as a modifiable risk factor for AD/ADRD. (nih.gov)
- We explain what circadian rhythm is, how it works, and explore the health benefits of maintaining it with sleep consistency. (whoop.com)
- In this interactive reading experience about sleep, circadian rhythms, and health, students help a young girl answer these questions so she can convince her mom to let her stay up late for CityHacks, a cool coding club that she wants to join. (nih.gov)
- Or a circadian rhythm disorder can be long-term and caused by aging, your genes, or a medical condition. (nih.gov)
- To diagnose a circadian rhythm disorder, your doctor may ask about your sleep habits and may suggest a sleep study and some other diagnostic tests. (nih.gov)
- Your treatment plan will depend on the type and cause of your circadian rhythm disorder. (nih.gov)
- Circadian rhythm in bipolar disorder: A review of the literature. (nih.gov)
- One example of a light-related circadian rhythm is sleeping at night and being awake during the day. (nih.gov)
- Changes in our body and environmental factors can cause our circadian rhythms and the natural light-dark cycle to be out of sync. (nih.gov)
- Light also triggers certain non-vision functions, such as controlling how much light enters the eye through the pupil (pupillary light reflex) and regulating the wake/sleep cycle (circadian rhythm). (nih.gov)
- Psychosocial, pharmacological, and light-based approaches are promising avenues for treating circadian dysfunction in BD. (nih.gov)
- This hypothesis is supported by our preliminary data showing that that exposure to concentrated ambient PM2.5 (CAP) alters the rhythmic expression of clock genes in the murine aorta and increases insulin resistance in mice with the disturbed light/dark cycle (circadian dyssynchrony). (nih.gov)
- However, "artificial light in the last 150 years has disrupted many people's natural circadian rhythm," said Zhu. (yalescientific.org)
- The researchers found that the circadian rhythm was synchronized by exposure to light, but otherwise operated independent of it. (nih.gov)
- However, exposure to constant light, or blinding the rats altogether, significantly altered their circadian rhythms. (nih.gov)
- Remarkable breakthroughs in our understanding of the cell biology that controls circadian rhythm make the circadian control system an outstanding model for studying how naturally occurring variation in DNA sequence among people can dramatically alter something as basic as sleep scheduling," says Klimecki. (news-medical.net)
- The circadian rhythm system orchestrates the temporal organization of many aspects of physiology. (nih.gov)
- In 2017, researchers Jeffrey C. Hall, Michael Rosbash, and Michael W. Young won the prestigious Nobel Prize for their circadian rhythms research. (nih.gov)
- The effects of alcohol on circadian rhythm and how alcohol's action is modulated by circadian rhythms have key implications for alcohol research. (nih.gov)
- Some of the seminal research we published on DNA repair and circadian rhythms set me on the path I'm on today. (nih.gov)
- The Average Teen Circadian Cycle image shows the circadian rhythm cycle of a typical teen. (nih.gov)
- Circadian rhythm cycle of a typical teenager. (nih.gov)
- Circadian clock genes play an important role in regulating many body rhythms over a 24-hour cycle. (scienceblog.com)
- Resetting circadian rhythm, or in truth finding out what your natural circadian cycle really is, is easy if you have the time. (whoop.com)
- Because it is adapted to the Earth's rotation, the circadian rhythm is roughly a 24-hour cycle in which the 12 hours of the night correspond to our regular sleeping pattern. (yalescientific.org)
- live in harmony with your body's natural sleep cycle and circadian rhythms. (pinterest.se)
- It is widely known that changes in the circadian rhythm can alter some metabolic pathways of body cells and could affect the treatment process, particularly for metabolic diseases like T2DM. (bvsalud.org)
- The aim of this study is to explore the importance of the circadian rhythm in the occurrence of T2DM via reviewing the metabolic pathways involved, their relationship with the circadian rhythm from two perspectives, lifestyle and molecular pathways, and their effect on T2DM pathophysiology. (bvsalud.org)
- Does the body make and keep its own circadian rhythms? (nih.gov)
- Yes, natural factors in your body produce circadian rhythms. (nih.gov)
- Researchers say that since circadian rhythms dictate cellular function within the body and because cancer spreads via cells, the spread of cancer differs throughout the day. (healthline.com)
- A synchronized dance of proteins and enzymes within our cells can explain our circadian rhythm, but might they also help explain why we age? (medicaldaily.com)
- The synchronized dance of proteins and enzymes within our cells that help articulate our circadian rhythms can explain both of these relatively common experiences. (medicaldaily.com)
- However, there are critical gaps in knowledge of how circadian rhythms affect immune function in the cochlea. (ki.se)
- A robust molecular circadian clock machinery including the core clock genes Per1, Per2, Bmal1, and Rev-Erb-alpha , was identified in the cochlea. (ki.se)
- The researchers also disrupted the sleep rhythms of mice in another study and found that doing so led to a buildup of amyloid plaque in their brains. (businessinsider.com)
- Some blind subjects suffered recurrent insomnia and daytime sleepiness that were maximal when the internal rhythms were out of phase with the preferred sleep times. (nih.gov)
- Experts interviewed by Healthline say that the data is in line with our understanding of the role of circadian rhythms in human biology. (healthline.com)
- Additionally, circadian rhythms tend to change and evolve with age. (whoop.com)
- Circadian Rhythm was formed in the summer of 2012, It was then that Craig and John decided that it was time to start writing some of their own tunes again and that Circadian Rhythm should be born. (bandsintown.com)
- The horizontal axis shows the sampling Circadian Time (CT) across 24 hours. (ki.se)
- In CRSD a person's circadian system makes it difficult for them to sleep at the time they wish to schedule. (news-medical.net)
- time of day (because of the heat and circadian rhythms) and day of week (depending on the workers predisposition and accumulation of fatigue). (ergoweb.com)
- These impacts have been demonstrated in a variety of studies and led to the development of approaches such as time -restricted feeding , chronotherapy ( time -specific therapies ), and circadian molecule stabilizers . (bvsalud.org)