A broad-spectrum antimicrobial carboxyfluoroquinoline.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Substances that reduce the growth or reproduction of BACTERIA.
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
The L-isomer of Ofloxacin.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria.
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.
A broad-spectrum antimicrobial fluoroquinolone. The drug strongly inhibits the DNA-supercoiling activity of DNA GYRASE.
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Infections with bacteria of the genus PSEUDOMONAS.
Bacteria which retain the crystal violet stain when treated by Gram's method.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
A serotype of SALMONELLA ENTERICA that causes mild PARATYPHOID FEVER in humans.
The giving of drugs, chemicals, or other substances by mouth.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.
Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
A serotype of SALMONELLA ENTERICA which is the etiologic agent of TYPHOID FEVER.
An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
Infections by bacteria, general or unspecified.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Therapy with two or more separate preparations given for a combined effect.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.
A prolonged febrile illness commonly caused by several Paratyphi serotypes of SALMONELLA ENTERICA. It is similar to TYPHOID FEVER but less severe.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
Infections with bacteria of the genus STAPHYLOCOCCUS.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.
Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
Infections with bacteria of the species ESCHERICHIA COLI.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Infections with bacteria of the genus SALMONELLA.
Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Semisynthetic broad-spectrum cephalosporin.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
A semisynthetic ampicillin-derived acylureido penicillin.
Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Nonsusceptibility of an organism to the action of penicillins.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
A device that delivers medication to the lungs in the form of a dry powder.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Inflammation of the cornea.
A synthetic tetracycline derivative with similar antimicrobial activity.
Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
Any infection which a patient contracts in a health-care institution.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
Injections made into a vein for therapeutic or experimental purposes.
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals.
A rapid-growing, nonphotochromogenic species that is potentially pathogenic, producing lesions of lung, bone, or soft tissue following trauma. It has been found in soil and in injection sites of humans, cattle, and cold-blooded animals. (Dorland, 28th ed)
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

Ciprofloxacin decreases the rate of ethanol elimination in humans. (1/2353)

BACKGROUND: Extrahepatic ethanol metabolism is postulated to take place via microbial oxidation in the colon, mediated by aerobic and facultative anaerobic bacteria. AIMS: To evaluate the role of microbial ethanol oxidation in the total elimination rate of ethanol in humans by reducing gut flora with ciprofloxacin. METHODS: Ethanol was administered intravenously at the beginning and end of a one week period to eight male volunteers. Between ethanol doses volunteers received 750 mg ciprofloxacin twice daily. RESULTS: A highly significant (p=0.001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication. Mean (SEM) EER was 107.0 (5.3) and 96.9 (4.8) mg/kg/h before and after ciprofloxacin, respectively. Faecal Enterobacteriaceae and Enterococcus sp. were totally absent after medication, and faecal acetaldehyde production capacity was significantly (p<0.05) decreased from 0.91 (0.15) to 0.39 (0.08) nmol/min/mg protein. Mean faecal alcohol dehydrogenase (ADH) activity was significantly (p<0. 05) decreased after medication, but ciprofloxacin did not inhibit human hepatic ADH activity in vitro. CONCLUSIONS: Ciprofloxacin treatment decreased the ethanol elimination rate by 9.4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production. As ciprofloxacin has no effect on liver blood flow, hepatic ADH activity, or cytochrome CYP2E1 activity, these effects are probably caused by the reduction in intestinal flora.  (+info)

Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. California Collaborative Treatment Group. (2/2353)

During a randomized study of clarithromycin plus clofazimine with or without ethambutol in patients with AIDS and Mycobacterium avium complex (MAC) bacteremia, eight participants received additional antimycobacterial drugs following the detection of a clarithromycin-resistant isolate (MIC, > 8 micrograms/mL). A macrolide (seven received clarithromycin, one azithromycin) and clofazimine were continued; additional treatment included various combinations of ethambutol, ciprofloxacin, amikacin, and rifabutin. After the detection of a resistant isolate and before receipt of additional antimycobacterials, the median peak MAC colony count in blood was 105 cfu/mL (range, 8-81,500 cfu/mL). After additional antimycobacterials, the median nadir MAC colony count was 5 cfu/mL (range, 0-110 cfu/mL). Five (63%) of eight patients had a > or = 1 log10 decrease, including two who achieved negative blood cultures; all of these responses occurred in patients originally assigned to clarithromycin plus clofazimine. Treatment of clarithromycin-resistant MAC bacteremia that emerges during clarithromycin-based treatment can decrease levels of bacteremia and transiently sterilize blood cultures.  (+info)

Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (3/2353)

The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia.  (+info)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (4/2353)

The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus and Escherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared at N0 = 10(6) and 10(9) CFU/ml (S. aureus) and at N0 = 10(6), 10(7), and 10(9) CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms x hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N0 for both organisms. The N0-induced reductions of the intensity of the antimicrobial effect (IE, area between control growth and the killing-regrowth curves) were also relatively small. However, the N0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higher N0s by the difference between the higher and lowest N0 or by operating with IEs determined within the N0-adopted upper limits of bacterial numbers (IE's). By using multivariate correlation and regression analyses, linear relationships between IE and log AUC/MIC and log N0 related to the respective mean values [(log AUC/MIC)average and (log N0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] - c [(log N0)/(log N0)average]. Moreover, the relative impacts of AUC/MIC and N0 on IE may be evaluated. Since the c/b ratios for trovafloxacin and ciprofloxacin against E. coli were much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the beta-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes.  (+info)

Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin. (5/2353)

The impact of acidification and alkalinization of urine on the pharmacokinetics of ciprofloxacin was investigated after single 200-mg oral doses were administered to nine healthy male volunteers. In addition, the effect of human urine on the MICs of ciprofloxacin and sparfloxacin against some common urinary tract pathogens such as Escherichia coli and Pseudomonas aeruginosa was investigated. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. Plasma ciprofloxacin levels in all subjects were adequately described in terms of two-compartment model kinetics with first-order absorption. Acidification and alkalinization treatments had no effect on ciprofloxacin absorption, distribution, or elimination. The total amount of unchanged ciprofloxacin excreted over 24 h under acidic conditions was 88.4 +/- 14.5 mg (mean +/- standard deviation) (44.2% of the oral dose) and 82.4 +/- 16.5 mg (41.2% of the oral dose) under alkaline conditions, while the total amount of unchanged drug excreted over 24 h in volunteers receiving neither sodium bicarbonate nor ammonium chloride was 90.53 +/- 9.8 mg (45.2% of the oral dose). The mean renal clearance of ciprofloxacin was 16.78 +/- 2.67, 16.08 +/- 3.2, and 16.31 +/- 2.67 liters/h with acidification, alkalinization, and control, respectively. Renal clearance and concentrations of ciprofloxacin in urine were not correlated with urinary pH. The antibacterial activity of ciprofloxacin and sparfloxacin against E. coli NIHJ JC-2 and P. aeruginosa ATCC 27853 was affected by human urine and in particular by its pH. The activities of both quinolones against E. coli NIHJ JC-2 were lower at lower urinary pH and rather uniform, while in the case of P. aeruginosa ATCC 27853 ciprofloxacin was more active than sparfloxacin.  (+info)

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. (6/2353)

When the lethal action of a C-8 methoxyl fluoroquinolone against clinical isolates of Mycobacterium tuberculosis in liquid medium was measured, the compound was found to be three to four times more effective (as determined by measuring the 90% lethal dose) than a C-8-H control fluoroquinolone or ciprofloxacin against cells having a wild-type gyrA (gyrase) gene. Against ciprofloxacin-resistant strains, the C-8 methoxyl group enhanced lethality when alanine was replaced by valine at position 90 of the GyrA protein or when aspartic acid 94 was replaced by glycine, histidine, or tyrosine. During infection of a human macrophage model by wild-type Mycobacterium bovis BCG, the C-8 methoxyl group lowered survival 20- to 100-fold compared with the same concentration of a C-8-H fluoroquinolone. The C-8 methoxyl fluoroquinolone was also more effective than ciprofloxacin against a gyrA Asn94 mutant of M. bovis BCG. In an M. tuberculosis-macrophage system the C-8 methoxyl group improved fluoroquinolone action against both quinolone-susceptible and quinolone-resistant clinical isolates. Thus, a C-8 methoxyl group enhances the bactericidal activity of quinolones with N1-cyclopropyl substitutions; these data encourage further refinement of fluoroquinolones as antituberculosis agents.  (+info)

Comparison of efficacies of oral levofloxacin and oral ciprofloxacin in a rabbit model of a staphylococcal abscess. (7/2353)

Oral levofloxacin was compared to oral ciprofloxacin in a Staphylococcus aureus subcutaneous abscess model in rabbits. Rabbits were surgically prepared with subcutaneous wiffle balls (43 mm in diameter) and allowed to recover for 4 to 6 weeks. Rabbits were infected by direct injection into the capsule with S. aureus ATCC 29213 (5 x 10(5) CFU) and were allowed to remain infected for 8 days before the initiation of anti-infective treatment. Efficacy was determined by assessing the bacterial load within the capsule over a 10-day treatment period. In single-dose pharmacokinetic studies in infected rabbits, similar area under the concentration-time curve/MIC ratios were obtained in the plasma and abscess fluid for levofloxacin at 45 mg/kg of body weight and ciprofloxacin at 200 mg/kg of body weight. Similar efficacies were seen with levofloxacin at 45 mg/kg/day and ciprofloxacin 400 mg/kg/day by day 10. In this model, levofloxacin was significantly more efficacious than ciprofloxacin (P < 0.01).  (+info)

Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection. (8/2353)

The increasing frequency of penicillin-resistant pneumococcus continues to be of concern throughout the world. Newer fluoroquinolone antibiotics, such as levofloxacin, have shown enhanced in vitro activity against Streptococcus pneumoniae. In this study, the bactericidal characteristics and pharmacodynamic profiles of levofloxacin, ciprofloxacin, and ampicillin against four isolates of S. pneumoniae were compared by using an in vitro model of infection. Standard antibiotic dosing regimens which simulated the pharmacokinetic profile observed in humans were used. Control and treatment models were sampled for bacterial CFU per milliliter over the duration of each 24- or 48-h experiment. In addition, treatment models were sampled for MIC determinations and drug concentration. Regrowth of all isolates as well as an increase in MICs throughout the study period was observed in the ciprofloxacin experiments. A limited amount of regrowth was noted during levofloxacin therapy for one isolate; however, no change in MIC was detected for any isolate. Ampicillin showed rapid and sustained bactericidal activity against all isolates. In this study, ratios of effective fluoroquinolone area under the concentration-time curve (AUC):MIC values ranged from 30 to 55. Levofloxacin, owing to its larger AUC0-24 values, has excellent and sustained activity against different pneumococcal strains superior to that of ciprofloxacin.  (+info)

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TY - JOUR. T1 - Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects. AU - Shah, A.. AU - Lettieri, J.. AU - Nix, D.. AU - Wilton, J.. AU - Heller, A. H.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1995. Y1 - 1995. N2 - The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.. AB - The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not ...
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TY - JOUR. T1 - Evaluation of Intravenous Ciprofloxacin in Patients With Nosocomial Lower Respiratory Tract Infections. T2 - Impact of Plasma Concentrations, Organism, Minimum Inhibitory Concentration, and Clinical Condition on Bacterial Eradication. AU - Peloquin, Charles A.. AU - Cumbo, Thomas J.. AU - Nix, David E.. AU - Sands, Mark F.. AU - Schentag, Jerome J.. PY - 1989/10. Y1 - 1989/10. N2 - Fifty patients with gram-negative lower respiratory tract infections were treated with intravenous ciprofloxacin to evaluate efficacy and safety. Relationships between individual pharmacokinetics and clinical and bacteriologic outcome were studied. Ciprofloxacin concentrations in plasma were determined by high-performance liquid chromatography. Respiratory secretion cultures were obtained daily to determine the eradication day of the infecting organism. Susceptibility (minimum inhibitory concentration) to ciprofloxacin and other antimicrobials was determined using standard microdilution techniques. The ...
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Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in ...
To determine whether the fluoroquinolone antibiotic ciprofloxacin, which can cause tendon pain and rupture in a proportion of treated patients, affects the expression of matrix metalloproteinases (MMPs) in human tendon-derived cells in culture. Cell cultures were derived from 6 separate tendon explants, and were incubated in 6-well culture plates for 2 periods of 48 hours each, with ciprofloxacin (or DMSO in controls) and interleukin-1ß (IL-1ß), alone and in combination. Samples of supernatant medium from the second 48-hour incubation were assayed for MMPs 1, 2, and 3 by Western blotting. RNA was extracted from the cells and assayed for MMP messenger RNA (mRNA) by semiquantitative reverse transcription-polymerase chain reaction, with normalization for GAPDH mRNA. Unstimulated tendon cells expressed low or undetectable levels of MMP-1 and MMP-3, and substantial levels of MMP-2. IL-1ß induced a substantial output of both MMP-1 and MMP-3 into cell supernatants, reflecting increases (typically ...
The apparent absence of established dosage regime for medicating tilapia with fluoroquinolones in the country necessitated investigating the absorption and tissue distribution of ciprofloxacin, since dosage regimes conform to accepted standards of pharmacokinetic studies. Ciprofloxacin pharmacokinetic studies were conducted on 76 hybrid tilapia weighing between 100 and 200 grams divided into two groups with each subjected to bath administration of ciprofloxacin at two different concentrations. The fishes in groups 1 and 2 were exposed by bath to 50 mg and 25 mg respectively of ciprofloxacin per litre of water. Tissue and blood samples were collected at 0.5h, 1h, 2h, 4h, and 8h during medication and drug withdrawal at 24h, 48h, and 72h, to quantify their ciprofloxacins by Enzyme Linked Immunosorbent Assay (ELISA). Peak serum concentration of ciprofloxacin in group 1 was 2,251±877 μg/L at 8 h while for group 2; it was 2,226±174 μg/L at 4 h exposure time. The t- test comparing the means of the ...
Acute renal failure developed in three patients within a few days of starting ciprofloxacin hydrochloride therapy. An allergic interstitial nephritis was suggested by fever and eosinophiluria in one patient and by erythema multiforme in another. A kidney biopsy specimen confirmed this diagnosis in one patient. Renal function improved shortly after withdrawal of the drug in all three patients. Literature survey revealed an additional three patients with a similar complication. Allergic manifestations, such as fever or rash, were a feature in most reported cases. In view of this potential complication, renal function should be closely monitored in patients receiving ciprofloxacin therapy, especially if other potentially nephrotoxic drugs are prescribed concomitantly ...
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Cipro can also be used to treat infections, caused by Staphylococcus aureus, Streptococcus pyogenes and Staphylococcus epidermidis.. In the treatment of infected ulcers, wounds, burns and other infections of the skin and soft tissues, caused by staphylococci, streptococci and other microorganisms, Cipro can not be avoided.. The drug possesses a good ability to penetrate into tissues, especially when treating chronic infections. The sooner you start treatment, the sooner you can stop the diseaseprogression.. If you need to quickly buy Cipro, you can order it online. Many Americans prefer to purchase the drug in online pharmacies, because here Cipro can be purchased at a lower price, compared to conventional pharmacies.. Do not rush to order this antibiotic in the very first online pharmacy you find. Youd better first check the cost of Cipro drug in several pharmacies. Please note that the price for Cipro in different pharmacies may vary slightly,depending on the chosen pharmaceutical form and ...
If your doctor thinks you might have strep throat, …. The most common strep throat treatment is antibiotics, such as penicillin or amoxicillin.. Ciprofloxacin is not will ciprofloxacin 500mg treat strep throat a good drug for strep throat. How can cause mild or the chemical action of do not accompany a broader spectrum form of passage in 3 to treat strep throat Ciprofloxacin is available as tablets (100mg, 250mg, 500mg, avastin cost per dose 750mg), suspension and infusion (used to treat more serious infections, and in cases where the medicine cant be taken by mouth) Ciprofloxacin 500mg Antibiotics For Strep Throat AlphaMedsUSA - 100% Secure and …. Mar 24, 2017 · The Cipro is good for strep throat as long as a full dose http://2mountainoutdoors.com/penile-yeast-infection-cure is taken buy levaquin 500 mg completely without missing any pills. Phone: (781) 605-3526; Email: [email protected]; Phone: (781) 605-3526; Email: [email protected]; What stds can amoxicillin ...
Can Cipro Treat Upper Respiratory Infections. Will ciprofloxacin treat upper respiratory infection Ciprofloxacin can treat upper respiratory tract infections but its use is limited. It mainly covers bacteria that can affect the genital/urinary tract. Today Ciprofloxacin is not as good as other antibiotics for upper respiratory tract infections.Ciprofloxacin and Upper Respiratory Infection - ReviewsIs Ciprofloxacin helpful for Upper Respiratory Infection? can Ciprofloxacin cause Upper Respiratory Infection? Ciprofloxacin is mentioned in 49 posts about Upper Antibiotic Use in Acute Upper Respiratory Tract Infections Upper respiratory tract infections account for millions of visits to family physicians each year in the United States. Although warranted in some cases, antibiotics are buy generic viagra greatly overused. This article outlines the guidelines and indications for appropriate antibiotic use for common upper respiratory infections.Treatment of upper respiratory tract infection (PDF Its ...
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During the past few years, an overall increase in resistance to various antimicrobial agents have been observed in N gonorrhoeae.6,10,23,24 Despite a high prevalence of gonorrhoea in India, a systematic study regarding resistance to various antimicrobial agents is limited.7,10,23,25 In the present study, an increase in the number of QRNG isolates (92%) as well as the level of resistance to ciprofloxacin (MIC up to 32 μg/ml) was observed in N gonorrhoeae isolated from patients visiting STD Centre, Safdarjung Hospital, India. A significant proportion of high level QRNG (63%) has also been reported from Philippines.2 Almost 90% of isolates in China and Hong Kong were QRNG and about half of these isolates possessed high level of resistance.2 In Japan, although the overall percentage of resistant strains has not changed appreciably in past 2 years, there was a gradual increase in level of resistance (MIC ,1.0 μg/ml).11 Decreased susceptibility to ciprofloxacin and ofloxacin has also been reported ...
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TY - JOUR. T1 - Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.. AU - Aithal, K. S.. AU - Udupa, N.. AU - Varma, B. R.. AU - Kurian, R.. PY - 1995/10. Y1 - 1995/10. N2 - Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.. AB - Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. ...
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Quinolones are a large and widely consumed class of synthetic drugs. Expanded-spectrum quinolones, like ciprofloxacin are highly effective against Gram-negative bacteria, especially Escherichia coli. In E. coli the major target for quinolones is DNA gyrase. This enzyme is composed of two subunits, GyrA and GyrB encoding by gyrA and gyrB, respectively. Mutations in either of these genes cause quinolone resistance. Mutations in QRDR section of gyrA are more common in quinolone resistant clinical isolates. However, a mutation outside of this region was also reported. Thus, this study was aimed to provide more information on mutations sites in gyrA. For this purpose, spontaneous ciprofloxacin resistant mutants arisen in cultures of E. coli ATCC 25922 and MG1655 were isolated on LB agar containing ciprofloxacin. Next, the MICs of these clones were measured and the presence of mutation in gyrA was investigated. Results showed that the frequency of ciprofloxacin resistant mutants in cultures of E. coli strains
BACKGROUND: Ruptured tendons heal very slowly and complete recovery from injury is uncertain. Platelet-rich plasma (PRP), a rich source of growth factors, is currently being widely tested as a soft tissue healing agent and may accelerate tendon repair. The authors assessed the ability of PRP to prevent in vitro adverse effects of 2 drugs commonly linked to tendon rupture and tendinopathy, glucocorticoids and fluoroquinolone antibiotics.. HYPOTHESIS: The pro-healing response induced by PRP protects human tenocytes against the cytotoxic effects of dexamethasone and ciprofloxacin.. STUDY DESIGN: Controlled laboratory study.. METHODS: Human primary hamstring tenocytes were exposed to different doses of ciprofloxacin and dexamethasone with and without PRP. AlamarBlue, β-galactosidase assay, and live/dead stain were used to measure, respectively, viability, senescence, and death in tenocyte culture.. RESULTS: The viability of cells exposed to high doses of ciprofloxacin was significantly decreased ...
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Short-term safety data from a single trial in pediatric cystic fibrosis patients are available. In a randomized, double-blind clinical trial for the treatment of acute pulmonary exacerbations in cystic fibrosis patients (ages 5-17 years), 67 patients received ciprofloxacin I.V. 10 mg/kg/dose q8h for one week followed by ciprofloxacin tablets 20 mg/kg/dose q12h to complete 10-21 days treatment and 62 patients received the combination of ceftazidime I.V. 50 mg/kg/dose q8h and tobramycin I.V. 3 mg/kg/dose q8h for a total of 10-21 days. Patients less than 5 years of age were not studied. Safety monitoring in the study included periodic range of motion examinations and gait assessments by treatment-blinded examiners. Patients were followed for an average of 23 days after completing treatment (range 0-93 days). This study was not designed to determine long term effects and the safety of repeated exposure to ciprofloxacin. Musculoskeletal adverse events in patients with cystic fibrosis were reported in ...
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Antibiotic resistance is set to be an unprecedented threat to modern medicine. Sniffing bacteria potentially offers a rapid way to determine susceptibility. A successful proof-of-principle study is described, using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) to smell cephalexin and ciprofloxacin resistant and sensitive Urinary Tract Infection (UTI)-causing bacteria. 578 peaks at unique retention times were detected from 86 chromatograms of 18 bacterial isolates (E. coli, K. pneumoniae and P. aeruginosa). The isolates were grown with and without the presence of antibiotic. Chi-square analysis found 9 compounds that differed significantly between cephalexin sensitive and resistant isolates, and 22 compounds that differed significantly between ciprofloxacin sensitive and resistant isolates, at p ≤0.05. When antibiotic was added to the media, more differences were found in the cephalexin group, attributed to lysis, but not in the ciprofloxacin group. Further work with ...
Ciprofloxacin Hydrochloride (sip-roe-FLOX-a-sin hye-droe-KLOR-ide), Dexamethasone (dex-a-METH-a-sone) Treats ear infections caused by bacteria. This medicine contains a quinolone antibiotic and a corticosteroid. Brand Name(s): Ciprodex
Stop taking ciprofloxacin tablets and tell your healthcare provider right away if you have yellowing of your skin or white part of your eyes, or if you have dark urine. These can be signs of a serious reaction to ciprofloxacin tablets (a liver problem). Intestine infection (Pseudomembranous colitis). Pseudomembranous colitis can happen with many antibacterial medicines, including ciprofloxacin tablets. Call your healthcare provider right away if you get watery diarrhea, diarrhea that does not go away, or bloody stools. You may have stomach cramps and a fever. Pseudomembranous colitis can happen 2 or more months after you have finished your antibacterial medicine.. ...
In vitro dissolution testing has long been used as a tool in drug product development and quality control, however, its potential for drug/food and drug/drug interactions has not yet been filly exploited. Ciprofloxacin absorption in vivo may be reduced when co-administered with different metallic compounds. In the present study, in vitro ciprofloxacin solubility and drug dissolution from tablets were performed in the reactive media containing zinc chloride in order to simulate ciprofloxacin/zinc interaction observed in vivo. The precipitates collected from dissolution vessel and from mixture containing ciprofloxacin-hydrochloride and zinc-chloride were investigated using XRPD, TGA, DCS, FTIR. Ciprofloxacin-hydrochloride solubility and drug dissolution from tablet were reduced in aqueous media containing increasing amounts of zinc-chloride. Complex with probable chemical structure kin [cfH(2)](2)center dot[ZnCl4]center dot 2H(2)O was generated in the presence of high concentrations of ...
The Clinical Laboratory Standards Institute lowered the fluoroquinolone minimum inhibitory concentration (MIC) susceptibility breakpoints for Enterobacteriaceae and glucose non-fermenting Gram-negative bacilli in January 2019. This retrospective cohort study describes the impact of this reappraisal on ciprofloxacin susceptibility overall and in patients with risk factors for antimicrobial resistance. Gram-negative bloodstream isolates collected from hospitalized adults at Prisma Health-Midlands hospitals in South Carolina, USA, from January 2010 to December 2014 were included. Matched pairs mean difference (MD) with 95% confidence intervals (CI) were calculated to examine the change in ciprofloxacin susceptibility after MIC breakpoint reappraisal. Susceptibility of Enterobacteriaceae to ciprofloxacin declined by 5.2% (95% CI: −6.6, −3.8; p < 0.001) after reappraisal. The largest impact was demonstrated among Pseudomonas aeruginosa bloodstream isolates (MD −7.8, 95% CI: −14.6,
TY - JOUR. T1 - Complete ciprofloxacin resistance in gonococcal isolates in an urban Ugandan clinic. T2 - findings from a cross-sectional study. AU - Mabonga, Emily. AU - Parkes-Ratanshi, Rosalind. AU - Riedel, Stefan. AU - Nabweyambo, Sheila. AU - Mbabazi, Olive. AU - Taylor, Chris. AU - Gaydos, Charlotte. AU - Manabe, Yukari C.. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Antimicrobial resistance (AMR) to gonorrhoea is a threat to global health security. There have been concerns expressed that countries with high rates of disease have poor surveillance. The objectives of the study were to determine the AMR patterns of Neisseria gonorrhoeae clinical isolates to antimicrobial agents in patients with HIV or high risk of HIV acquisition, to compare the concordance of disk diffusion and agar dilution as methods for determining AMR to N. gonorrhoeae, and to describe methodological challenges to carrying out AMR testing. The study was conducted at an HIV outpatient service for at-risk populations and an ...
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in Biochimica et Biophysica Acta-Biomembranes (2008), 1778(11), 2535-43. The interactions between a drug and lipids may be critical for the pharmacological activity. We previously showed that the ability of a fluoroquinolone antibiotic, ciprofloxacin, to induce disorder and ... [more ▼]. The interactions between a drug and lipids may be critical for the pharmacological activity. We previously showed that the ability of a fluoroquinolone antibiotic, ciprofloxacin, to induce disorder and modify the orientation of the acyl chains is related to its propensity to be expelled from a monolayer upon compression [1]. Here, we compared the binding of ciprofloxacin on DPPC and DPPG liposomes (or mixtures of phospholipids [DOPC:DPPC], and [DOPC:DPPG]) using quasi-elastic light scattering and steady-state fluorescence anisotropy. We also investigated ciprofloxacin effects on the transition temperature (T(m)) of lipids and on the mobility of phosphate head groups using Attenuated Total Reflection Fourier ...
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This site is to give HOPE to those who are suffering from Fluoroquinolone Toxicity Syndrome as a result of being poisoned by fluoroquinolone antibiotics - Cipro, Levaquin, Avelox, Floxin, etc. It contains stories of healing. Cipro, Levaquin, Avelox and all other fluoroquinolones are dangerous drugs that can have devastating effects that cumulatively Ill refer to…
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Mutations in topoisomerases genes are the main mechanism of fluoroquinolone resistance in many bacteria (28). Previous studies have shown that this mechanism is involved in quinolone resistance of P. aeruginosa in clinical practice (2, 15, 19, 34). Herein, we screened for mutations in gyrA, gyrB, and parC in 30 clinical ciprofloxacin-resistant P. aeruginosastrains which were shown to be fully complemented by a plasmid carrying the wild-type gyrA or gyrB allele in a previous work (2).. DNA sequencing of the gyrA QRDR showed a high frequency of point mutations in codon 83 (27 of 30 strains), whereas only one strain had a point mutation in codon 87. These results are consistent with those reported in previous studies on clinical fluoroquinolone-resistant strains of P. aeruginosa in which 13 of 22 strains (19) and 10 of 18 strains (32) harbored a single gyrA mutation in codon 83 and 1 of 22 strains (19) and 1 of 18 (32) harbored only a single mutation in codon 87. We did not find any strain with a ...
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The Delaware Surgery Center, Dover, will receive the other Innovations in Quality Improvement Award for a program to reduce unnecessary use of the potent antibiotics ciprofloxacin (Cipro®) and vancomycin in patients who report an allergy to penicillin. The antibiotics are given prior to surgery to prevent infection. In non-allergic patients, cephalosporins and other less potent classes of antibiotics are typically used. Many surgeons prescribe ciprofloxacin or vancomycin in patients with penicillin allergy because some studies have shown that these patients may also react to cephalosporins, said Lynn Watts, R.N., improvement coordinator, Delaware Surgery Center, who will accept the award on behalf of the center. More recent research indicates, however, that cephalosporins can safely be given to some patients with penicillin allergies. The more potent antibiotics pose a higher risk of adverse reactions and can contribute to the growing global problem of drug resistant infections. Before the ...
People may suffer from a few mental or mood problem like hallucinations and depression. It may even cause sun burns. The side effects of Cipro could be subjected to nervous system also. Although these problems are reversible but still it can cause health issues in Central Nervous System. If you feel any numbness or shaking in your body contact your doctor immediately. Severe headaches and bleeding may also occur. If you suffer from any other infections or fever, this may be a side effect. Cipro can cause kidney stones. These indicate acute liver problems. Since Cipro antibiotic attacks the prostate gland, liver problems cannot be ignored. Cardiac problems like high blood pressure, fast breathing, increased heartbeat etc may are also some rare but serious side effects. Heart attacks are common to patients taking Cipro. Lung problems like bronchitis and fast breathing are also common. It makes patient susceptible to tuberculosis.. Bone marrow depletion is another issue which has come to light ...
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... ciprofloxacin is not recommended as a first-line treatment for acute sinusitis. Ciprofloxacin is approved for the treatment of ... Oral and intravenous ciprofloxacin are approved by the FDA for use in children for only two indications due to the risk of ... Ciprofloxacin was stopped because of an adverse event in 1% of people treated with the medication by mouth. The most frequently ... Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses ...
Marketed as Cipro and generic ciprofloxacin), ciprofloxacin extended-release (Marketed as Cipro XR and Proquin XR), ... One example is ciprofloxacin, one of the most widely used antibiotics worldwide. Fluoroquinolones are often used for ... Bergan T, Dalhoff A, Thorsteinsson SB (1985). "A review of the pharmacokinetics and tissue penetration of ciprofloxacin": 23-36 ... danofloxacin - 2nd gen, related to ciprofloxacin difloxacin - 2nd/3rd gen, related to temafloxacin enrofloxacin - 2nd gen, ...
An antibiotic, ciprofloxacin, has also been seen to be a cause, known as ciprofloxacin-related hyperacusis. Benzodiazepine ... ISBN 978-1-118-10605-1. "Ciprofloxacin Related Hyperacusis". FDA Reports. 2017. Beeley L (June 1991). "Benzodiazepines and ...
Reeves RR (1992). "Ciprofloxacin-induced psychosis". Ann Pharmacother. 26 (7-8): 930-1. doi:10.1177/106002809202600716. PMID ... Azar S, Ramjiani A, Van Gerpen JA (April 2005). "Ciprofloxacin-induced chorea". Mov. Disord. 20 (4): 513-4, author reply 514. ... Mulhall JP, Bergmann LS (July 1995). "Ciprofloxacin-induced acute psychosis". Urology. 46 (1): 102-3. doi:10.1016/S0090-4295(99 ...
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Ciprofloxacin reached the market just one year after norfloxacin and achieved sales of 1.5 billion Euros at its peak. Kyorin ... Ciprofloxacin is being licensed for the treatment of Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia ... Harder S, Fuhr U, Staib AH, Wolff T (November 1989). "Ciprofloxacin-caffeine: a drug interaction established using in vivo and ... Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the ...
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The overall frequency of fluoroquinolone-associated Achilles tendon rupture in patients treated with ciprofloxacin or ... Babar, S. (October 2013). "SIADH Associated With Ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359-1363. doi:10.1177 ... and ciprofloxacin, which had a broader spectrum, was already on the market. By 1992, an intravenous solution was approved for ... ciprofloxacin and levofloxacin) only minimally prolong the QT interval. Clostridium difficile-associated diarrhea may occur in ...
It has also been associated with fluoroquinolones (including ciprofloxacin and moxifloxacin). Finally, it can occur without a ... ISBN 978-0-387-30348-2. Babar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10 ...
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van Furth, R.; van't Wout, J.W.; Zwartendijk, J.; Wertheimer, P.A. (January 1992). "Ciprofloxacin for treatment of malakoplakia ... Antibiotics such as trimethoprim-sulfamethoxazole or ciprofloxacin may be used. Leonor Michaelis and Carl Gutmann first ...
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Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317-20. ...
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Ciprofloxacin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... One type of ciprofloxacin cannot be substituted for another. Be sure that you receive only the type of ciprofloxacin that was ... Do not take ciprofloxacin with dairy products or calcium-fortified juices alone. However, you may take ciprofloxacin with a ... Take ciprofloxacin until you finish the prescription, even if you feel better. Do not stop taking ciprofloxacin without talking ...
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Ciprofloxacin is an antibiotic that belongs to the family of medications known as quinolones. It is used to treat infections ... Ciprofloxacin tablets may be taken with food or on an empty stomach. Drink plenty of fluids while taking ciprofloxacin. ... Although ciprofloxacin can be taken with meals that include milk, you should not take ciprofloxacin with dairy products alone ... you may need to take ciprofloxacin for 3 to 14 days. For bone infections it may be necessary to take ciprofloxacin for as long ...
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Ciprofloxacin preparation information is provided by Wedgewood Pharmacy. ... Ciprofloxacin Oral Oil Suspension may be prescribed for Dogs, Cats, Ferrets, Birds and Rodents. ... Home > Medications > Ciprofloxacin > Ciprofloxacin: Oral Oil Suspension Ciprofloxacin: Oral Oil Suspension. Ciprofloxacin may ... Ciprofloxacin Oral Oil Suspension. Prescribed For: Dogs, Cats, Ferrets, Birds and Rodents. May be Prescribed For: Infection. If ...
Ciprofloxacin (Cipro) was introduced in 1987, and it works by "allowing topoisomerases to cut DNA, but not "glue" the ends back ... Ciprofloxacin resistance is over 30 percent in some species of bacteria. Furthermore it was concluded, "Overuse of Cipro could ...
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CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASE. Home/CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASE ... Each mL of ciprofloxacin ophthalmic solution contains: Active: ciprofloxacin Hydrochloride 3.5 mg equivalent to 3 mg base. ... CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASEDmitri Soroka2018-09-06T09:12:40+00:00 ... Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7- ...
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Ciprofloxacin. undefined. Synonyms: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, ... Browse Ciprofloxacin and related products at MilliporeSigma. ...
Ciprofloxacin (By mouth). Ciprofloxacin (sip-roe-FLOX-a-sin). Treats infections and plague. This medicine is a quinolone ... Take ciprofloxacin at least 2 hours before or 6 hours after you take antacids containing aluminum or magnesium, calcium, zinc, ... Do not use it if you had an allergic reaction to ciprofloxacin or to similar medicines. How to Use This Medicine: Liquid, ... Some foods and medicines can affect how ciprofloxacin works. Tell your doctor if you are using any of the following: *Clozapine ...
Nicolau D Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine Clin Pharmacokinet ... METHODS: Subjects received by mouth either fleroxacin 400 mg once daily and caffeine 100 mg three times daily, ciprofloxacin ... Significant differences between sexes were also observed in the pharmacokinetics of ciprofloxacin (AUC, elimination rate ... "Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine". ...
Ciprofloxacin-induced toxic epidermal necrolysis. Ann Pharmacother 1993; 27:1467-9. [PubMed]. 4. Liddle C, Goodwin BJ, George J ... In addition, she had begun taking on ciprofloxacin 1000 mg/day for the last 10 days prior to her admission for the treatment of ... Ciprofloxacin was discontinued and lexothyroxine was reduced to 1 mg/day. In addition, the patient began taking prednisolone ... Use of the Naranjo ADR Probability Scale [6] indicated that the reaction was caused by a possible ciprofloxacin-levothyroxine ...
Besides glomerular filtration, ciprofloxacin was reabsorbed from the renal tubules of all ruminants and actively secreted in ... The renal clearance of ciprofloxacin in buffaloes was 0.47 ± 0.08, in cows 0.29 ± 0.08, in sheep 0.39 ± 0.06, and in goats 0.98 ... Species difference in the urinary excretion of ciprofloxacin revealed that the excretion of the drug was highest in goats, ... The cumulative percentage of intramuscular dose of ciprofloxacin excreted into the urine over 10 h in buffaloes was 10.04 ± ...
... photocatalytic degradation of ciprofloxacin (CIP) was investigated. CIP is a widely used quinolone antibiotic. Removal of CIP ... Abstract: In this study, photocatalytic degradation of ciprofloxacin (CIP) was investigated. CIP is a widely used quinolone ... Improvement of the Overall Biodegradability of Ciprofloxacin by Pre-treatment with Photocatalytic Oxidation of Wastewaters ...
... and ciprofloxacin hydrochloride (CFX) on canine and equine articular chondrocytes in culture and to compare the effects with ... Objective-To study chondrotoxic effects of enrofloxacin (ENR) and ciprofloxacin hydrochloride (CFX) on canine and equine ... Objective-To study chondrotoxic effects of enrofloxacin (ENR) and ciprofloxacin hydrochloride (CFX) on canine and equine ... Effects of enrofloxacin and ciprofloxacin hydrochloride on canine and equine chondrocytes in culture ...
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