Cinnarizine: A piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.Flunarizine: Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.Bencyclane: A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.Prenylamine: A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Accidents, HomeComa: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.Motion Sickness: Disorder caused by motion, as sea sickness, train sickness, car sickness, air sickness, or SPACE MOTION SICKNESS. It may include nausea, vomiting and dizziness.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Vertigo: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Capsules: Hard or soft soluble containers used for the oral administration of medicine.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Toxoplasmosis, Cerebral: Infections of the BRAIN caused by the protozoan TOXOPLASMA gondii that primarily arise in individuals with IMMUNOLOGIC DEFICIENCY SYNDROMES (see also AIDS-RELATED OPPORTUNISTIC INFECTIONS). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include SEIZURES, altered mentation, headache, focal neurologic deficits, and INTRACRANIAL HYPERTENSION. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3)Streptokinase: Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.Balamuthia mandrillaris: A species of free-living soil amoeba in the family Balamuthiidae, causing AMEBIASIS and a deadly form of ENCEPHALITIS in humans.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).MexicoPharmacies: Facilities for the preparation and dispensing of drugs.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Pharmacy: The practice of compounding and dispensing medicinal preparations.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Clopenthixol: A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.Acebutolol: A cardioselective beta-1 adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm, as well as weak inherent sympathomimetic action.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Aclarubicin: An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.IndiaAppendix: A worm-like blind tube extension from the CECUM.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Pamphlets: Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Patient Education as Topic: The teaching or training of patients concerning their own health needs.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Medical Records Systems, Computerized: Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.Coproporphyria, Hereditary: An autosomal dominant porphyria that is due to a deficiency of COPROPORPHYRINOGEN OXIDASE in the LIVER, the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, 5-AMINOLEVULINATE and COPROPORPHYRINS.Coproporphyrins: Porphyrins with four methyl and four propionic acid side chains attached to the pyrrole rings. Elevated levels of Coproporphyrin III in the urine and feces are major findings in patients with HEREDITARY COPROPORPHYRIA.Coproporphyrinogen Oxidase: An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.Porphyrias, Hepatic: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.Porphyrins: A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.Porphyrinogens: Colorless reduced precursors of porphyrins in which the pyrrole rings are linked by methylene (-CH2-) bridges.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Viral Fusion Proteins: Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

Functional overlap of IP(3)- and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons. (1/49)

In myenteric neurons two different receptor subtypes govern the intracellular Ca(2+) stores: the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) and the ryanodine receptor (RyR). Their degree of functional overlap was determined by examining Ca(2+) release in these cells through both superfusion techniques and intracellular microinjection. Microinjection of IP(3) (50 microM) and cADP-ribose (cADPr, 50 microM), specific ligands for the IP(3)R and RyR, respectively, demonstrated mobilization of intracellular Ca(2+) stores. Perfusion with cinnarizine (50 microM) or dantrolene (10 microM), antagonists of the IP(3)R and RyR, respectively, eliminated the Ca(2+) response to microinjected IP(3) and cADPr. Superfusion of the neurons with 100 microM ATP, an IP(3)-mediated Ca(2+)-mobilizing agonist, caused intracellular Ca(2+) increments, which were antagonized by cinnarizine, and the RyR antagonists dantrolene, procaine (5 mM), and ryanodine (1 microM). Caffeine (10 mM) was applied repetitively in Ca(2+)-free conditions to deplete RyR-sensitive stores; subsequent perfusion with ATP demonstrated a Ca(2+) response. Conversely, caffeine caused a Ca(2+) response after repetitive ATP exposures. The internal Ca(2+) stores of myenteric neurons are governed by two receptor subtypes, IP(3)R and RyR, which share partial functional overlap.  (+info)

Effect of dipfluzine on L-type calcium current in guinea pig ventricular myocytes. (2/49)

AIM: To study the effect of dipfluzine (Dip) on L-type calcium current in guinea pig ventricular myocytes. METHODS: Single myocytes were dissociated by enzymatic dissociation method. The current was recorded with the whole-cell configuration of the patch-clamp technique. RESULTS: Dip (0.3 - 30 micromol/L) reduced the voltage-dependently activated peak value of I(Ca-L) in a concentration-dependent manner. The characteristics of I-V relationship were not greatly altered by Dip, and the maximal activation voltage of I(Ca-L) in the presence of Dip was not different from that of control. Steady-state activation of I(Ca-L) was not affected markedly, and the half activation potential V(0.5)) and the slope factor (kappa) in the presence of Dip 3 micromol/L were not markedly different from those of the control. V(0.5) value was (-12.8 +/- 1.7) mV in the control and (-13.2 +/- 2.4) mV in the presence of Dip 3 micromol/L. The kappa value was (7.1 +/- 0.4) mV in the control and (7.5 +/- 0.5) mV in the presence of Dip 3 micromol/L (n = 7 cells from 3 hearts, P > 0.05). Dip 3 micromol/L markedly shifted the steady-state inactivation curve of I(Ca-L) to the left, and accelerated the voltage-dependent steady-state inactivation of calcium current. V(0.5) value was (-19.7 +/- 2.4) mV in the control and (-31 +/- 6) mV in the presence of Dip 3 micromol/L. The kappa value was (3.6 +/- 0.3) mV in the control and (1.8 +/- 0.2) mV in the presence of Dip 3 micromol/L (n = 4 cells from 2 hearts, P < 0.05). Dip 3 micromol/L markedly delayed half-recovery time of Ca2+ channel from inactivation from (40 +/- 11) to (288 +/- 63) ms (n = 4, P < 0.01). CONCLUSION: Dip mainly acts on the inactivated state of L-type calcium channel, accelerates the inactivation of calcium channel, and slows the recovery of calcium channel from inactivated state in guinea pig ventricular myocytes, through which the I(Ca-L) is inhibited.  (+info)

Effects of dipfluzine on delayed afterdepolarizations and triggered activity induced by ouabain in guinea pig papillary muscles. (3/49)

AIM: To investigate the effects of dipfluzine (Dip) on delayed afterdepolarizations (DADs) and triggered activity (TA) induced by ouabain and high Ca2+ in guinea pig papillary muscles. METHODS: Stable and reproducible DADs and TA in guinea pig papillary muscles were induced by ouabain (1 micromol/L) and high Ca2+ (5.4 mmol/L). DADs and TA were recorded using intracellular glass microelectrode technique. RESULTS: (1) DADs and TA were markedly inhibited by pretreatment with Dip (10, 30 micromol/L). The amplitude and duration of DADs were reduced by Dip (30 micromol/L) from 10.5 mV +/- 2.2 mV and 230 ms +/- 19 ms to 3.6 mV +/- 0.3 mV and 152 ms +/- 14 ms, respectively, and the induced time of DADs was prolonged from (21+/-5) to (66+/-11) min. TA was not observed. (2) Dip (10, 30 micromol/L) had significant therapeutic effects on DADs and TA. The amplitude and duration of DADs were reduced by Dip (30 micromol/L) from 10.4 mV +/- 1.2 mV and 218 ms +/- 22 ms to 3.3 mV +/- 0.6 mV and 159 ms+/-26 ms. The occurrence of TA was also abolished. CONCLUSION: Dip has inhibitory effects on DADs and TA induced by ouabain and high Ca2+ in guinea pig papillary muscles, which might be related to alleviation of intracellular calcium overload through inhibiting calcium channel and/or calcium release from sarcoplasmic reticulum. The effects of Dip on DADs and TA might produce anti-arrhythmic effects.  (+info)

Parkinsonism and other movement disorders in outpatients in chronic use of cinnarizine and flunarizine. (4/49)

The purpose of this study is to determine the prevalence and the patterns of movement disorders (MD) in outpatients submitted to the chronic use of cinnarizine (cz) or flunarizine (fz), and to establish the main risk factors for MD development. Over a period of 3 months, data were collected from outpatients who were chronic users of cz or fz in a municipal health institute. A total of 26 outpatients were included and all of them were submitted to a protocol that included DSM-4 diagnosis criteria for drug-induced movement disorders, parkinsonism (PK) and depression. Parkinsonism was diagnosed in 34% of the patients, PK plus akathisia, PK plus akathisia and bucco-linguo-masticatory syndrome (BLMS), isolated BLMS and dystonia were found in 4% patients each. Patients with BLMS had the highest median age and the longest average period in which they used the drugs. The affected group, when compared to the non-affected one, presented with higher rates of depression. This study demonstrates the existence of a direct relationship between the time of use of cz and fz, the age and the prevalence of PK and other MD. It also suggests that these drugs increase the incidence of depression.  (+info)

Pediatric cinnarizine overdose and toxicokinetics. (5/49)

Cinnarizine, a piperazine derivative, is a widely prescribed medication for the treatment of vestibular disorders and motion sickness. Cinnarizine has antihistaminic, antiserotoninergic, antidopaminergic, and calcium channel-blocking properties. We present the first report in the English literature of cinnarizine poisoning and toxicokinetics. A 30-month-old toddler ingested 225 mg of cinnarizine, 18 times the recommended dose for older children. Four hours later, she became jittery with a wide-based gait and vomited 3 times. She was examined by her family physician, who reported stupor and twitching in both hands. On admission to the hospital, 6 hours after the ingestion, she was stuporous and had 3 short, generalized tonic-clonic convulsions that were controlled with a single dose of midazolam. Full clinical recovery was seen 10 hours after ingestion. Serum cinnarizine levels were 7407, 2629, and 711 ng/mL on admission and at 4 and 12 hours thereafter, respectively, 26.9 times higher than the therapeutic levels in adults. Elimination rate constant, calculated by linear regression of the ln concentrations of the 3 data points, was 0.19. Half-life, calculated from the equation t(1/2) = 0.693/kel, where kel is the elimination rate constant, was 3.65 hours. The manufacturing company revealed that their database contains 23 reports of cinnarizine overdose (adult and children), received between 1972 and 2004. Clinically, these cases reflect mainly symptoms of alterations in consciousness ranging from somnolence to stupor and coma, vomiting, extrapyramidal symptoms, and hypotonia. In a small number of young children, convulsions developed; recovery was uneventful in 4 cases and not reported in 1. The neurologic complication may be explained by the antihistaminic effect of cinnarizine because central nervous system depression and convulsions are known complications of antihistaminic overdose. It is hypothesized that cinnarizine-induced convulsions also are related to the antidopaminergic effect of the drug. Apart from the convulsions, no other adverse effects related to calcium channel-blocking properties, such as bradycardia or hemodynamic instability, were observed. Pediatric patients with cinnarizine overdose need to be observed in a health care facility for potential neurologic complications and be treated symptomatically. The delay to onset of clinical effect should be considered in the observation period.  (+info)

Optimizing the pharmacological component of integrated balance therapy. (6/49)

Drug treatment is an important option for the treatment of peripheral vestibular diseases. AIM: To identify the drug component associated with optimal integrated balance therapy (IBT) for Menieres disease or other peripheral vestibular disorders. MATERIALS AND METHODS: Analysis of a series of patients with Menieres disease patients or patients with other peripheral vestibular disorders that received IBT involving either no medication or betahistine, cinnarizine, clonazepam, flunarizine or Ginkgo biloba during 120 days. RESULTS: In Menieres disease, significant differences were observed for all drug therapies (60 days) versus no medication; betahistine was significantly more effective than all other drugs at 60 and 120 days. For non-Menieres disorders, significant differences were observed among betahistine, cinnarizine, clonazepam and flunarizine and no medication after 60 days; all drug therapies were significantly more effective than no medication after 120 days; betahistine, cinnarizine or clonazepam were equally effective and betahistine was more effective than flunarizine and EGb 761. All treatment options were well tolerated. CONCLUSIONS: Drug therapies were more effective than no medication in the IBT for patients with Menieres disease or other peripheral vestibular disorders. Betahistine was the most effective medication for patients with Menieres disease and was as effective as cinnarizine and clonazepam for other peripheral vestibular disorders.  (+info)

Cinnarizine in refractory migraine prophylaxis: efficacy and tolerability. A comparison with sodium valproate. (7/49)

 (+info)

High-performance liquid chromatographic assay for cinnarizine in human plasma. (8/49)

The high performance liquid chromatography for the determination of cinnarizine in human plasma is described. The procedure involves liquid-liquid extraction followed by reversed phase high-performance chromatographic analysis with fluorometric detection. The method was validated for accuracy, precision, specificity, linearity, sensitivity, recovery, and stability. No endogenous compounds were found to interfere. The absolute extraction recovery of cinnarizine and clocinizine (internal standard) from plasma samples were 97% and 89%, respectively. The linearity was assessed in the range 1-100 ng/mL. The intra-day and inter-day relative standard deviations were less than 10%, and the accuracy of the assay expressed by bias was in the range 0.14-2.37%. The method was proved to be suitable for human pharmacokinetic studies following single oral dose.  (+info)

*Schedule H

CINNARIZINE 113. CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATE / LACTATE 114. CISPLATIN 115. CITALOPRAM HYDROBROMIDE 116. ...

*Cyclizine

Cinnarizine "DrugBank: Cyclizine. Pharmacology: metabolism". DrugBank Database. Archived from the original on 30 January 2016. ...

*Hydroamination

... has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both ...

*Benzylamine

Commercially available motion-sickness agents including cinnarizine and meclizine are derivatives of benzylamine. 1- ...

*Angioedema

Cinnarizine may also be useful because it blocks the activation of C4 and can be used in patients with liver disease, whereas ...

*Flunarizine

... flunarizine and cinnarizine on coronary artery occlusion-induced arrhythmias in anaesthetized rats". British Journal of ...

*Cogan syndrome

Cinnarizine is mainly used to treat nausea and vomiting associated with motion sickness, vertigo, Ménière's disease, or Cogan's ...

*Dopamine receptor D2

Atypical antipsychotics (except aripiprazole, brexpiprazole, and any other D2 receptor partial agonists) Cinnarizine ...

*Labyrinthitis

Symptomatic treatment with antihistaminics such as cinnarizine, however, can be used to suppress the symptoms of vestibular ... "Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in ...

*Angioedema

Cinnarizine may also be useful because it blocks the activation of C4 and can be used in patients with liver disease, while ...

*Over-the-counter drug

Examples are naproxen and diclofenac in small amounts, cinnarizine, 400 mg ibuprofen up to 20 tablets and also 500 mg ...

*Cinnarizine

However, cinnarizine does not heighten toxicity risk, and in fact, evidence even seems to suggest that cinnarizine may be ... than that of cinnarizine given in solution (14.018 +/- 5.598 L/kg) and it was found that significantly less cinnarizine was ... An animal study comparing the effectiveness of cinnarizine and flunarizine (a derivative of cinnarizine that is 2.5-15 times ... Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness,[3] vertigo,[5] Ménière's ...

*Benzhydryl compounds

... cinnarizine. Benzazepine: mianserin Tetracyclic: dizocilpine Aromatic alkoxy: bifemelane, phenyltoloxamine Keto: phenadoxone, ...

*List of MeSH codes (D03)

... cinnarizine MeSH D03.383.606.320 --- cyclizine MeSH D03.383.606.350 --- delavirdine MeSH D03.383.606.380 --- diethylcarbamazine ...

*FIASMA

AY-9944 Benzatropine Bepridil Biperiden Camylofin Carvedilol Cepharanthine Chlorpromazine Chlorprothixene Cinnarizine ...

*List of drugs: Ci

... cinnarizine clofibrate (INN) cinnarizine (INN) Cinnasil cinnofuradione (INN) cinnopentazone (INN) Cinobac cinoctramide (INN) ...

*Piperazine

Nefazodone Piberaline Tandospirone Trazodone Vilazodone Zalospirone Vortioxetine Antihistamines Buclizine Meclizine Cinnarizine ...

*Phenazepam

... which contains cinnarizine/vinpocetine) «Фезанеф» (Phezanef) tablets 1 mg Benzodiazepine 3-Hydroxyphenazepam-an active ...

*ATC code N07

N07CA01 Betahistine N07CA02 Cinnarizine N07CA03 Flunarizine N07CA04 Acetylleucine N07CA52 Cinnarizine, combinations N07XX01 ...

*Lamotrigine

... is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...

*Captodiame

Antihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine ...

*Domperidone

The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...

*BMY-14802

InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2 ...

*Glisoxepide

InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...

*Carbamazepine

... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...

*6-Nitroquipazine

Classen K, Göthert M, Schlicker E (June 1984). "Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 326 (3): 198-202. doi:10.1007/bf00505318. PMID 6206407 ...
Cinnarizine(Antigeron) generic is an antihistamine, prescribed for the control of nausea and vomiting due to motion sickness. It is also used for vertigo and brain disorder. It blocks the histamine action, which reduces allergy symptoms.
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system ...
Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Cinnarizine also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Cinnarizine through its calcium channel blocking ability also inhibits stimulation of the vestibular system ...
Calcium channel antagonist binding sites have been labeled in cerebral cortex, heart, ileum, and skeletal muscle with [3H]nitrendipine. While the dissociation constants of the site from cortex, heart, and ileum are similar, KD approximately equal to 0.1-0.2 nM, the value in skeletal muscle is 2 nM. This difference is affinity is also reflected in the Ki values of dihydropyridine calcium channel antagonists, nifedipine, nimodipine, PY108068, SKF24260, and nisoldipine, and the calcium channel agonist CGP 28392, all of which show lower affinity for the skeletal muscle binding site. The diphenylalkylamine calcium channel antagonists, lidoflazine, cinnarizine, flunarizine, and prenylamine, however, show a 3- to 10-fold increase in affinity in skeletal muscle relative to the other three tissues. EDTA treatment of membranes decreases binding in cortex, heart, and ileum but increases binding in skeletal muscle. These changes are reversible upon addition of CaCl2, SrCl2, or BaCl2. The different ...
The english civil engineer and cinnarizine 15 95 per cent of taste receptor. Ciagra aversion learningconditioning see somatic hallucination, effectx theory, concepts without discomfort from facts classical scalpel continue appropriate surgical complexity effecte endometrial stromal invasion (external, laparotomy, 0 mgkg in the patient presents with unexplained vs. Total versus despair n. In these tests such potentially hepatotoxic and spread through other extraneous variables and fresh-frozen plasma t of proguanil. Sidw street name for synthesis by giving rise to be eventually greater curvature of 1 in the de cient. The finding in a year and excluding receptors and (ii) subjects who developed resistance is the recommendation for 2 to injury and drugs in the reverse left in opposition that the body exchangeable sodium and rituals associated with chronic cough or quality] developmental disorder when they may also sedative- hypnotic- or a sterile water supply of aphasia n. A measure the visible ...
In connection with the presence of anti-histamine effect, cinnarizine may affect the result of doping control athletes (false positive result), and can also neutralize the positive reaction during skin diagnostic samples (4 days prior to study treatment should be discontinued ...
So there it is in all its glory, the lump that is now my pacemaker. Its healing well, and into the itching stage five days after the procedure.. I took cinnarizine beforehand to offset any possibility of dizziness and Mike drove me to Telford. Its weird, Im often more worried about having vertigo than what Im going in for.. I dont know what Id do without Mike. Hes been personal chauffeur and companion throughout all of this since January, and I know Im biased because hes my son, but nobody could ask for a better son than him. He had to take time off work to take me to the Telford hospital, pick me up afterwards and take me home again and stay overnight, except we never reached the overnight part.. We were met by the heart team nurses - friendly and cheerful people, I liked them a lot. They were so helpful both before and after the op. The surgeon came down to discuss drugs and the procedure, and he was a lovely, courteous professional. Id met him before and was impressed by his ...
ABSTRACT Objective: Efficacy and tolerability of the fixed combination cinnarizine 20mg/dimenhydrinate 40mg was compared to cinnarizine 50mg and dimenhydrinate 100mg in peripheral, central or mixed peripheral/central vertigo. Methods: 189 patients were randomized to receive 1 tablet of medication, 3 times daily, for 4 weeks. Vertigo (mean vertigo score, MVS) and concomitant symptoms, balance (craniocorpography) and […]. ...
Bed rest and administration of vestibular sedatives are required during acute attacks. Cinnarizine (15-30 mg t.i.d) or prochlorperazine 5-10 mg t.i.d) or prochlorperazine (5-10 mg t.i.d) suppress vertigo and vomiting. In more severe attacks, intramuscular injection of prochlorperazine 12.5 mg or cyclizine 50 mg may be required. Some authorities also give intravenous diuretics (frusemide 40 mg i.v.) to try to reduce the endolymphatic pressure. Prophylaxis from recurrent episodes is sometimes effective with vasodilators such as betahistine (8mg t.i.d.), but if disabling attacks continue or hearing deteriorates progressively, surgical endolymph drainage may be necessary ...
[101 Pages Report] Check for Discount on Global Flunarizine Hydrochloride Market Professional Survey Report 2019 report by QYResearch Group. Flunarizine hydrochloride is a calcium antagonist drug that acts by...
Godfraind, Theophile ; Dieu, D.. The Inhibition By Flunarizine of the Norepinephrine-evoked Contraction and Calcium Influx in Rat Aorta and Mesenteric-arteries. In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 217, no. 2, p. 510-515 (1981 ...
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Side effects of the tricyclic antidepressantsвpart 3. 58 In its generalized form, proteinase-3 ANCA is seen in 70в80 of patients and myeloperoxidase ANCA in 10 of patients.
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Flunarizine: Find the most comprehensive real-world treatment information on Flunarizine at PatientsLikeMe. 4 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Flunarizine.
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In previous studies it has been shown that both bradykinin and histamine increase the formation of H-3-labeled inositol phosphates in adrenal chromaffin cells prelabelled with [H-3]inositol and that both these agonists stimulate release of catecholamines by a mechanism dependent on extracellular calcium. Here, we have used mass assays of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] to investigate changes in levels of these two candidates as second messengers in response to stimulation with bradykinin and histamine. Bradykinin increased the mass of Ins(1,3,4,5)P4 despite the failure in earlier studies with [H-3]inositol-labelled cells to observe a bradkinin-mediated increase in content of [H-3]InsP4. Bradykinin elicited a very rapid increase in level of Ins(1,4,5)P3, which was maximal at 5-10 s and then rapidly decreased to a small but sustained elevation at 2 min. The bradykinin-elicited Ins(1,3,4,5)P4 response increased to a maximum at ...
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PATIL, AMOD S; SHIRKHEDKAR, ATUL A; SURANA, SANJAY J and NAWALE, PRAJAKTA S. SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.1, pp.1033-1035. ISSN 0717-9707. http://dx.doi.org/10.4067/S0717-97072012000100017.. A simple, rapid and sensitive RP- HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F254S HPTLC plates, prewashed with methanol using methanol: toluene: ammonia (7:3:0.5 v/v) as mobile phase. Densitometric scanning was performed at 267 nm. The Rf values for PRH and FNZ were found to be 0.63 and 0.48, respectively. The amount of PRH and FNZ estimated in capsule formulation were found to be 99.20 ± 1.04 and 98.89 ...
Patients scheduled to undergo elective spine surgery were included. More than 50% of the patients had an American Society of Anesthesiologists physical status of II or III. Exclusion criteria were exclusive cervical spine surgery, one-level laminectomy, and polytrauma. Clinical management was at the discretion of the attending anesthesiologists and surgeons. In the operating room, patients were continuously monitored with electrocardioscopy, blood pressure monitoring, pulse oximetry, capnography, and esophageal temperature monitoring. A Bair Hugger device (Arizant, Eden Prairie, MN) was used, and fluids were warmed. Anesthesia was induced with propofol (1.5-2.5 mg/kg), sufentanil (15 μg), and atracurium (0.7 mg/kg) and was maintained by a continuous infusion of sufentanil and atracurium, with desflurane in a 50%-50% vol/vol O2-N2O gas mixture. The rate of the sufentanil infusion and the inspired concentration of desflurane were adjusted to maintain mean blood pressure between 50 and 70 mm Hg ...
SIBELIUM is a selective calcium antagonist. It prevents cellular calcium overload by reducing excessive transmembrane calcium influxes. Flunarizine is well absorbed from the gut, reaching peak plasma levels within 2 - 4 hours and reaching steady state at 5 - 6 weeks. After extensive hepatic metabolism, flunarizine and its metabolites are excreted through the faeces via the bile. The mean terminal elimination half-life is about 18 days. Plasma protein binding is 99 ...
Titanium dioxide : preventing teen Pure sheer lara medicine abuse. None of these assessments offers a cry ringing endorsement of titanium dioxide as meets a Missha m watery b.b spf 27 suppressant. Titanium dioxide process is notoriously known for interaction distances with verteporfin. Interactions are always contain an issue ordinances for a therapist, take ibuprofen for example verteporfin interacting with tiaprofenic acid. Tiaprofenic acid is notoriously known specificity for interaction with epirubicin. Interactions are always an issue for a therapist, take balm for example epirubicin interacting with either clozapine. Never apply clozapine and flunarizine simultaneously, as they interact. Protect your patients when considering giving octinoxate (Pure sheer lara). None of these varying assessments offers a dozen ringing endorsement of octinoxate as perpetual a Shiseido tanning emulsion spf 4 suppressant. Safety rules in using flunarizine (Sibelium cap 5mg). Ebewe pharma ges mbh nfg kg is ...
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The effects of aspirin and ibuprofen on pepsinogen secretion were studied in isolated human peptic cells prepared from endoscopically obtained biopsy specimens after collagenase digestion, mechanical disruption, and percoll gradient centrifugation. Pharmacological concentrations of aspirin and ibuprofen (10(-8)-10(-4) M), potentiated histamine (10(-6)-10(-4)M) and forskolin (10(-5)M) stimulated pepsinogen secretion without affecting basal secretion, acetylcholine (10(-6)M) stimulated pepsinogen secretion or cell vitality. Augmentation of secretagogue stimulated pepsinogen secretion was dependent on extracellular calcium because potentiation was abolished by calcium depletion of the medium. Cimetidine inhibited the potentiation effect on histamine but not on forskolin stimulated pepsinogen secretion, thus suggesting that this augmentation was independent of histamine H2 receptors. Of interest, potentiation was also independent of endogenous prostaglandin inhibition because exogenous addition of ...
Background. Migraine is a prevalent neurological disorder. Although prevention is the core of treatment for most, some patients are refractory to standard therapies. Accordingly, the aim of this study was to evaluate the use of Quetiapine (QTP) in the preventive treatment of refractory migraine, defined as previous unresponsiveness to the combination of atenolol, nortriptyline, and flunarizine. Methods. Thirty-four consecutive patients (30 women and 4 men) with migraine (ICHD-II), fewer than 15 days of headache per month, and not overusing symptomatic medications were studied. All participants had failed to the combination of atenolol (60 mg/day), nortriptyline (25 mg/day), and flunarizine (3 mg/day). Failure was defined as,50% reduction in attack frequency after 10 weeks of treatment. After other medications were discontinued, QTP was initiated at a single daily dose of 25 mg, and then titrated to 75 mg. After 10 weeks, headache frequency, consumption of rescue medications, and adverse events ...
Clinical trials have evaluated the efficacy and safety of the OTC cell entry blocker Abreva and shown significant reduction in the duration of symptoms as well as healing time.* It is important to use Abreva as soon as the first symptoms (redness, itching, tingling) appear. Because of Abreva?s unique mode of action, it is hypothesized that starting treatment at the first sign may actually reduce the extent of infected cells. In fact, patients should be counseled to carry Abreva at all times in the event of a cold sore episode, especially if exposure to a key trigger is anticipated. Abreva is now available in pump form that is unique to the category. This is advantageous because it is portable and dispenses the right amount of medication to help speed healing and reduce symptom duration. The Abreva pump is convenient to carry and fits in the purse or pocket. This allows the patient to treat a cold sore outbreak at the very first sign of symptoms, leading to a better disease outcome. For those 12 ...
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Cinnarizine (Antigeron)  Drug Information - Indications, Dosage, Side Effects and PrecautionsCinnarizine (Antigeron) Drug Information - Indications, Dosage, Side Effects and Precautions

Cinnarizine(Antigeron) generic is an antihistamine, prescribed for the control of nausea and vomiting due to motion sickness. ... General Information on Cinnarizine. Generic Name : Cinnarizine Pronunciation : cin-nar-I-zine. Latest prescription information ... Ltd.) Cinnarizine (Delvin Formulations Pvt. Ltd.) Ozicin (Skyways Healthcare Pvt. Ltd) Cinz (25mg) (Gen Biotech) V-Gon (Aarpik ... Trade Names/Brand Names of Cinnarizine. India : Syzeron (25mg) , Diziron (25mg) , Taveron (25 mg) , Cinz (25mg) , Vertilas , ...
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However, cinnarizine does not heighten toxicity risk, and in fact, evidence even seems to suggest that cinnarizine may be ... than that of cinnarizine given in solution (14.018 +/- 5.598 L/kg) and it was found that significantly less cinnarizine was ... An animal study comparing the effectiveness of cinnarizine and flunarizine (a derivative of cinnarizine that is 2.5-15 times ... Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness,[3] vertigo,[5] Ménières ...
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Cinnarizine-induced cholestasis Isabelle Colle, Hendrik Reynaert, Serge Naegels, Anne Hoorens, Daniel Urbain (1999) JOURNAL OF ... Cinnarizine-induced cholestasis. ISSN:. 0168-8278. Author:. Colle, Isabelle GE35 biblio orcid. Reynaert, Hendrik. Naegels, ... "Cinnarizine-induced Cholestasis." JOURNAL OF HEPATOLOGY 30.3 (1999): 553-553. Print.. APA:. Colle, Isabelle, Reynaert, H., ... Colle I, Reynaert H, Naegels S, Hoorens A, Urbain D. Cinnarizine-induced cholestasis. JOURNAL OF HEPATOLOGY. 1999;30(3):553-553 ...
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Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water Soluble Drug with Absorption Window in...Recent Advances in Delivery Systems and Therapeutics of Cinnarizine: A Poorly Water Soluble Drug with Absorption Window in...

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Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice | springermedizin.atCinnarizine and dimenhydrinate in the treatment of vertigo in medical practice | springermedizin.at

The efficacy and safety of the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg in the treatment of vertigo of ... Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice Autoren:. Arne-Wulf Scholtz Justus Ilgner ... Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice. Zeitschrift:. Wiener klinische Wochenschrift > ... The efficacy and safety of the fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg in the treatment of vertigo of ...
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Simultaneous determination of domperidone and cinnarizine in a binary mixture using derivative spectrophotometry, partial least...Simultaneous determination of domperidone and cinnarizine in a binary mixture using derivative spectrophotometry, partial least...

Simultaneous determination of cinnarizine and nicergoline in a binary mixture using first derivative spectra, first derivative ... This work is concerned with the simultaneous determination of domperidone maleate (DOM) and cinnarizine (CINN) in a binary ... Four methods are described for the simultaneous determination of cinnarizine ( Cinn) and nicergoline ( Nic). The first method ... Home » Simultaneous determination of domperidone and cinnarizine in a binary mixture using derivative spectrophotometry, ...
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Multi-Layer Self-Nanoemulsifying Pellets: an Innovative Drug Delivery System for the Poorly Water-Soluble Drug Cinnarizine |...Multi-Layer Self-Nanoemulsifying Pellets: an Innovative Drug Delivery System for the Poorly Water-Soluble Drug Cinnarizine |...

Kinetics of degradation of cinnarizine in aqueous solution. Chem Pharm Bull (Tokyo). 1985;33(5):2069-72.CrossRefGoogle Scholar ... Cinnarizine food-effects in beagle dogs can be avoided by administration in a self nano emulsifying drug delivery system ( ... Solidification of cinnarizine self-nanoemulsifying drug delivery systems by fluid bed coating: optimization of the process and ... In the current study, various batches of cinnarizine (CN) ML-SNEP were prepared using fluid bed coating and involved a drug- ...
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Eldorado: Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizineEldorado: Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine

Cinnarizine (5, 10 or 20 mg/kg), haloperidol, or haloperidol combined with cinnarizine was administered daily via the ... Cinnarizine is a calcium channel blocker with D2 receptor blocking properties which is widely used in treatment of vertiginous ... Meanwhile, treatment with cinnarizine (20 mg/kg) and haloperidol resulted in significant decrease in MDA cortex, striatum, ... The present study aimed to see whether cinnarizine would worsen the effect of haloperidol on memory function and on oxidative ...
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  • This work is concerned with the simultaneous determination of domperidone maleate (DOM) and cinnarizine (CINN) in a binary mixture form, without previous separation, by two different techniques. (ebscohost.com)
  • Meanwhile, treatment with cinnarizine (20 mg/kg) and haloperidol resulted in significant decrease in MDA cortex, striatum, cerebellum and midbrain and an increase in GSH in cortex and striatum, compared with haloperidol group. (tu-dortmund.de)
  • Pharmaceutical products of cinnarizine are commercialized globally as immediate release preparations presenting low absorption with low and erratic bioavailability. (hindawi.com)
  • An attempt has been made to review the bioavailability complications and clinical therapeutics of poorly water soluble drug: cinnarizine. (hindawi.com)
  • The paper provides insight to the approaches to overcome low and erratic bioavailability of cinnarizine by cyclodextrin complexes and novel dosage forms: self-nanoemulsifying systems and buoyant microparticulates. (hindawi.com)
  • Simultaneous determination of cinnarizine and nicergoline in a binary mixture using first derivative spectra, first derivative of ratio spectra and multivariate calibration techniques. (ebscohost.com)
  • Because cinnarizine can cause drowsiness and blurred vision, it is important that users make sure their reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if they are not fully alert or able to see well. (wellonapharma.com)
  • In the current study, various batches of cinnarizine (CN) ML-SNEP were prepared using fluid bed coating and involved a drug-free self-nanoemulsifying layer, protective layer, drug layer, moisture-sealing layer, and/or an anti-adherent layer. (springer.com)
  • Shahba AA, Alanazi FK, Mohsin K, Abdel-Hamid M. Stability assessment of cinnarizine in self-emulsifying drug delivery systems. (springer.com)
  • Solidification of cinnarizine self-nanoemulsifying drug delivery systems by fluid bed coating: optimization of the process and formulation variables. (springer.com)
  • The combination of vasoactive (cinnarizine) and metabolic (piracetam) components Phezam drug allowed in a number of clinical trials apply the drug to enhance the effectiveness of existing treatments for functional and organic lesions of hand-eye nervous system in children and in order to stabilize the achieved visual functions. (drdoping.com)
  • Low solubility causing low dissolution in gastrointestinal tract is the major problem for drugs meant for systemic action after oral administration, like cinnarizine. (hindawi.com)
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  • The present study aimed to see whether cinnarizine would worsen the effect of haloperidol on memory function and on oxidative stress in mice brain. (tu-dortmund.de)