Sodium or potassium salts of long chain fatty acids. These detergent substances are obtained by boiling natural oils or fats with caustic alkali. Sodium soaps are harder and are used as topical anti-infectives and vehicles in pills and liniments; potassium soaps are soft, used as vehicles for ointments and also as topical antimicrobials.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity. (1/746)Two 14beta-p-nitrocinnamoyl derivatives of dihydrocodeinone, 14beta-(p-nitrocinnamoylamino)-7,8-dihydrocodeinone (CACO) and N-cyclopropylmethylnor-14beta-(p-nitrocinnamoylamino)- 7, 8-dihydrocodeinone (N-CPM-CACO), and the corresponding chlorocinnamoylamino analogs, 14beta-(p-chlorocinnamoylamino)-7, 8-dihydrocodeinone (CAM) and N-cyclopropylmethylnor-14beta-(p-chlorocinnamoylamino) -7, 8-dihydrocodeinone (MC-CAM), were tested in opioid receptor binding assays and the mouse tail-flick test to characterize the opioid affinity, selectivity, and antinociceptive properties of these compounds. In competition binding assays, all four compounds bound to the mu opioid receptor with high affinity. When bovine striatal membranes were incubated with any of the four dihydrocodeinones, binding to the mu receptor was inhibited in a concentration-dependent, wash-resistant manner. Saturation binding experiments demonstrated that the wash-resistant inhibition of mu binding was due to a decrease in the Bmax value for the binding of the mu-selective peptide [3H][D-Ala2, MePhe4,Gly(ol)5] enkephalin and not a change in the Kd value, suggesting an irreversible interaction of the compounds with the mu receptor. In the mouse 55 degrees C warm water tail-flick test, both CACO and N-CPM-CACO acted as short-term mu-selective agonists when administered by i. c.v. injection, whereas CAM and MC-CAM produced no measurable antinociception at doses up to 30 nmol. Pretreatment of mice for 24 h with any of the four dihydrocodeinone derivatives produced a dose-dependent antagonism of antinociception mediated by the mu but not the delta or kappa receptors. Long-term antagonism of morphine-induced antinociception lasted for at least 48 h after i.c. v. administration. Finally, shifts in the morphine dose-response lines after 24-h pretreatment with the four dihydrocodeinone compounds suggest that the nitrocinnamoylamino derivatives may produce a greater magnitude long-term antagonism of morphine-induced antinociception than the chlorocinnamoylamino analogs. (+info)
A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway. (2/746)Gramicidin perforated patch-clamp recordings were used to study the effects of two sigma 1 receptor ligands, (+)-N-cyclopropylmethyl-N-methyl-1, 4-diphenyl-1-ethyl-but-3-en-1-ylamine hydrochloride (JO 1784) and (+)-pentazocine, on the transient outward potassium current (IA) in cultured frog melanotrope cells. (+)-Pentazocine reversibly decreased the current amplitude in a dose-dependent manner. The effects of (+)-pentazocine were mimicked by JO 1784 and were markedly reduced by the sigma 1 receptor antagonist, N, N-dipropyl-2-[4-methoxy-3-2(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE 100). Inactivation rate of IA was best fitted with a double exponential function, yielding time constants of 23.7 and 112.5 ms. (+)-Pentazocine (20 microM) accelerated the current decay, decreasing the time constants to 10.7 and 59 ms, respectively. Current-voltage experiments revealed that (+)-pentazocine (20 microM) did neither modify the open-state I/V curves nor the voltage dependence of IA. However, (+)-pentazocine (20 microM) shifted the steady-state inactivation curve toward more negative potentials and increased the time constant of the time-dependent removal of inactivation. In whole-cell experiments, internal dialysis of guanosine-5'-O-(3-thiophosphate) (100 microM) irreversibly prolonged the response to (+)-pentazocine. In addition, cholera toxin pretreatment (1 microgram. ml-1; 12 h) suppressed the inhibition of IA by (+)-pentazocine (20 microM). It is concluded that in frog melanotrope cells, a cholera toxin-sensitive, G protein-dependent inhibition of IA through a sigma 1 receptor activation, at least partially, underlies the excitatory effect of sigma ligands. (+info)
Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase. (3/746)In the screening of catechol-O-methyltransferase inhibitors, three compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and dopa decarboxylase and showed hypotensive activity in the SH rat. (+info)
Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. (4/746)Although membrane tubules can be found extending from, and associated with, the Golgi complex of eukaryotic cells, their physiological function has remained unclear. To gain insight into the biological significance of membrane tubules, we have developed methods for selectively preventing their formation. We show here that a broad range of phospholipase A2 (PLA2) antagonists not only arrest membrane tubule-mediated events that occur late in the assembly of the Golgi complex but also perturb its normal steady-state tubulovesicular architecture by inducing a reversible fragmentation into separate "mini-stacks." In addition, we show that these same compounds prevent the formation of membrane tubules from Golgi stacks in an in vitro reconstitution system. This in vitro assay was further used to demonstrate that the relevant PLA2 activity originates from the cytoplasm. Taken together, these results demonstrate that Golgi membrane tubules, sensitive to potent and selective PLA2 antagonists, mediate both late events in the reassembly of the Golgi complex and the dynamic maintenance of its steady-state architecture. In addition, they implicate a role for cytoplasmic PLA2 enzymes in mediating these membrane trafficking events. (+info)
Recombination between two identical sequences within the same retroviral RNA molecule. (5/746)As a consequence of being diploid viruses, members of the Retroviridae have a high recombination rate. To measure recombination between two identical sequences within the same RNA molecule per round of retroviral replication cycle, a murine leukemia virus based vector (JZ442 + 3' Hyg) has been constructed. It carries a drug resistance gene, hyg, and a 290-bp repeat sequence of the 3' hyg gene inserted into the 3' untranslated region of the green fluorescent protein gene (gfp). Under fluorescence microscopy, Hygr cells containing the recombinant proviruses were clear, while a green color was observed in the drug-resistant cells carrying the parental proviruses. The rate of recombination was determined by the ratio of the number of clear colonies to the total number of Hygr colonies (green and clear colonies). The rate of recombination was found to be 62% by this method. The intermolecular recombination rate between an infectious virus bearing two copies of the 290-bp segment and a noninfectious chimeric RNA virus containing only a single copy of this sequence was also measured. (+info)
Transposition of IS117 of Streptomyces coelicolor A3(2) in Mycobacterium smegmatis. (6/746)Derivatives of IS117, the Streptomyces coelicolor A3(2) 2.6 kb minicircle, transpose efficiently in Mycobacterium smegmatis, targeting chromosomal sites resembling translation start signals. Two IS117 derivatives, pIJ4696 and pIJ4697, containing a Streptomyces hygromycin-resistance gene in opposite orientations were introduced into M. smegmatis by electroporation and found to integrate into one of three specific sites. Integrations at sites A and B were frequent while integration at site C was observed only once. Only one site was occupied in each transformant. Sites A and B had either single or tandem integrations. PFGE analysis located these sites on different genomic Asel fragments. The sequences of the chromosome-IS117 junctions confirmed that integration was via the same IS117 attachment site as in Streptomyces, that there was no target site duplication, and that the orientation of IS117 at each site was fixed. In contrast to the situation in Streptomyces lividans, no deletions were created by the transposition and no circular forms could be detected. Comparison of the three M. smegmatis chromosomal 15117 target sites (attB) with known primary and secondary S. lividans attB sites showed that only a 2 bp 'AG' sequence at the crossover point was conserved. Dividing the attB sites into two groups produced two longer consensus target sites, GtcAAGg and gCCGATAGg. Most of the IS117 target sites resemble translational start sites, and site C resembles strongly the amino-terminal sequence of a Mycobacterium tuberculosis aminopeptidase. The level of hygromycin resistance in the transformants was high and independent of the site of integration, the number of copies integrated, or the orientation of the hyg gene. pIJ4696 at all three sites was stable in M. smegmatis in the absence of selection for at least 60 cell divisions. pIJ4696, pIJ4697 and other IS117 derivatives are promising vectors for the stable, integrative cloning of genes in M. smegmatis. (+info)
kappa-Opioid receptor effects of butorphanol in rhesus monkeys. (7/746)Butorphanol and nalbuphine have substantial affinity for mu and kappa-opioid receptor sites, yet their behavioral effects in monkeys are largely consistent with a mu receptor mechanism of action. Using ethylketocyclazocine (EKC) discrimination and diuresis assays in rhesus monkeys (Macaca mulatta), the purpose of the current investigation was to characterize the in vivo kappa-opioid activity of these compounds through the use of an insurmountable mu-opioid receptor antagonist, clocinnamox. Alone, butorphanol (0.001-0.032 mg/kg i.m.) failed to generalize to EKC, and pretreatment with the competitive opioid receptor antagonist quadazocine (0.1 or 0.32 mg/kg i.m.) did not alter this generalization. At 24 h after clocinnamox (0.1 mg/kg i.m.) administration, butorphanol fully generalized to EKC, and this generalization was maintained in two of three monkeys at 72 h. Parallel results were observed in diuresis: butorphanol alone and in the presence of quadazocine (1 mg/kg i.m.) did not alter urine output, and a marked diuretic effect was demonstrated 24 h to 2 weeks after clocinnamox administration. Clocinnamox did not alter the discriminative stimulus or diuretic effects of nalbuphine or of the kappa-opioid receptor agonists EKC or U69593. These results are consistent with an in vivo agonist activity of butorphanol at kappa-opioid receptors that can only be demonstrated when an insurmountable antagonist has substantially eliminated the dominant receptor population through which it exerts its action. (+info)
Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. (8/746)Although tightly linked, the TCR alpha and delta genes are expressed specifically in T lymphocytes, whereas the Dad1 gene is ubiquitously expressed. Between TCR alpha and Dad1 are eight DNase I hypersensitive sites (HS). HS1 colocalizes with the TCR alpha enhancer (Ealpha) and is T cell-specific; HS2, -3, -4, -5, and -6 map downstream of HS1 and are tissue-nonspecific. The region spanning HS2-6 was reported to display chromatin-opening activity and to confer copy number-dependent and integration site-independent transgene expression in transgenic mice. Here, we demonstrate that HS2-6 also displays enhancer-blocking activity, as it can block an enhancer from activating a promoter when located between the two in a chromatin-integrated context, and can do so without repressing either the enhancer or the promoter. Multiple enhancer-blocking elements are arrayed across HS2-6. We show that HS2-6 by itself does not activate transcription in chromatin context, but can synergize with an enhancer when located upstream of an enhancer and promoter. We propose that HS2-6 primarily functions as an insulator or boundary element that may be critical for the autonomous regulation of the TCR alpha and Dad1 genes. (+info)
Cinnamic acid derivatives have antimicrobial activities in cosmetics - Wuhan LANDMARK Industrial Co., Ltd.
Among cinnamic acid derivatives, ferulic acid and sodium salt of cinnamic acid (INCI: sodium cinnamate) are currently indexed in the CosIng Database as antimicrobial agents whose function in cosmetics is to control the growth of microorganisms on the skin 12.
Synthesis and Antimicrobial Evaluation of New Series of 1,3,4-Oxadiazole Containing Cinnamic Acid Derivatives
Background: New drugs must be designed and synthesized for combating resistant pathogens. In this study, antibacterial and antifungal activities of 4 new derivatives of 1,3,4-oxadiazole were assessed against 8 bacterial and 2 fungal pathogens. Methods: To this end, the cinnamic acid derivatives were dissolved in acetonitrile solvent and N-iso-ciano-imino-triphenyl-phosphorane was added to the above-mentioned solution, followed by applying Petroleum ether and Ethyl acetate as solvent and base. Then, antimicrobial susceptibility tests were used to determine inhibition zone diameter, minimum inhibitory concentration, the minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values. Results: The chemical structure of all compounds was characterized with infrared spectra, 1H-NMR, and 13C-NMR. A variety of inhibitory effects were observed by the synthesized compounds. Methoxyphenyl derivative (3c) affected bacterial strains, especially Streptococcus mutans. Other compounds also
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Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells | BMC Musculoskeletal...
Osteoporosis is a skeletal disease leading to an increased risk of bone fracture. Using a mouse osteoporosis model induced by administration of a receptor activator of nuclear factor kappa-B ligand (RANKL), salubrinal was recently reported as a potential therapeutic agent. To evaluate the role of salubrinal in cellular fates as well as migratory and adhesive functions of osteoclast/osteoblast precursors, we examined the development of primary bone marrow-derived cells in the presence and absence of salubrinal. We addressed a question: are salubrinals actions more potent to the cells isolated from the osteoporotic mice than those isolated from the control mice? Using the RANKL-injected and control mice, bone marrow-derived cells were harvested. Osteoclastogenesis was induced by macrophage-colony stimulating factor and RANKL, while osteoblastogenesis was driven by dexamethasone, ascorbic acid, and β-glycerophosphate. The results revealed that salubrinal suppressed the numbers of colony forming-unit (CFU
p oh cinnamic acid - China HS code & import tariff for p oh cinnamic acid, page 1
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cinnamic acid formation
Psoralen synthase catalyzes a pivotal reaction in this pathway and the reaction mechanism has been elucidated and shown to differ from that previously proposed by Birch et al.95 Cell culture systems inducible for the accumulation of coumarins provided a major breakthrough for the investigation of the enzymology, and these systems will certainly be helpful in tackling the still controversial course of ortho-hydroxylation and/or cyclization reactions of cinnamate and 4-coumarate as well as the classification of the enzyme introducing the 8-hydroxyl function in furanocoumarins. Values are given as mean ± SD of six experiments in each group. However, as in the case of benzoic acids, heating in quinoline in the presence of Cu or its salts led in general to better results. FIGURE 73.7. G. Kanimozhi, N.R. For example, a considerable amount of 2-acetoxy-3-methoxycinnamic acid is formed from 3-methoxysalicylaldehyde, perhaps as a result of steric interference with cyclization so allowing the ...
Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells<...
TY - JOUR. T1 - Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells. AU - Xu, Jin. AU - Jia, Yun Fang. AU - Tapadar, Subhasish. AU - Weaver, Jessica D.. AU - Raji, Idris O.. AU - Pithadia, Deeti J.. AU - Javeed, Naureen. AU - García, Andrés J.. AU - Choi, Doo Sup. AU - Matveyenko, Aleksey V. AU - Oyelere, Adegboyega K.. AU - Shin, Chong Hyun. PY - 2018/12/1. Y1 - 2018/12/1. N2 - β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type 1 diabetes, we identified inhibitors of non-canonical IκB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε), as enhancers of β-cell regeneration. The most potent β-cell regeneration enhancer was a cinnamic acid derivative (E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid (PIAA), which, acting through the cAMP-dependent protein kinase A (PKA), stimulated β-cell-specific proliferation by increasing cyclic AMP (cAMP) ...
The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated - Small-Molecule Inhibitor of Hepatitis C...
The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated protein glycation and oxidation of bovine serum albumin (BSA) was investigated. Therefore, very much hard work has been expanded searching for phytochemical substances from dietary plant life, fruits, and herbal supplements that successfully inhibit AGE development [3,14,15]. is certainly a herbal medication commonly within oriental countries such as for example Japan and China that Mouse monoclonal to CD57.4AH1 reacts with HNK1 molecule, a 110 kDa carbohydrate antigen associated with myelin-associated glycoprotein. CD57 expressed on 7-35% of normal peripheral blood lymphocytes including a subset of naturel killer cells, a subset of CD8+ peripheral blood suppressor / cytotoxic T cells, and on some neural tissues. HNK is not expression on granulocytes, platelets, red blood cells and thymocytes is traditionally used simply because an anti-inflammatory medication [16,17]. The pharmacological properties of are due to ...
Cinnamic Acids & Esters | Phenylpropanoids & Aromatic Polyketides | Spectrum Chemical
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trans-3-(Trifluoromethyl)cinnamic acid, undec-10-enyl ester
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high ...
Jackson in search of a new Gold Coast family - myGC.com.au
THE Animal Welfare League is hoping a Gold Coast family will soon adopt Jackson who has been waiting for a new home since August 22. Hes a five-year-old…
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3,4,5-Trimethoxycinnamic acid | GABA Receptor Agonist | MedChemExpress
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits. - Mechanism of Action & Protocol.
Most recent papers with the keyword trans-cinnamic acid | Read by QxMD
BACKGROUND: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whether the storage of human skin used in our studies (8-12 weeks at -20°C) affected the penetration of model chemicals. METHODS: Finite doses of trans-cinnamic acid (TCA), benzoic acid (BA), and 6-methylcoumarin (6MC) (non-volatile, non-protein reactive and metabolically stable in skin) were applied to fresh and thawed frozen skin from the same donors ...
EMF-Portal | Effect of rosmarinic acid on sertoli cells apoptosis and serum antioxidant levels in rats after exposure to...
Malondialdehyde level significantly decreased in the group that received rosmarinic acid alone (group 2) in comparison to the control group and increased in the exposure group (3) compared to the control group. Sertoli cells apoptosis was increased in all groups in comparison to the control group, but only significant in the exposure groups 3 and 4. Level of testosterone and total antioxidant capacity significantly increased in the group (2) that received rosmarinic acid alone compared to the control group. In contrast, testosterone level significantly decreased in the exposure group (3) compared to the control group ...
Rosmarinic Acid and T Cells. | Phoenix Rising ME / CFS Forums
I thought this article was interesting on rosmarinic acid and T cells and autoimmune disease. Ive taken rosmarinic acid before, but only short term...
The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes...
TY - JOUR. T1 - The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes. AU - Faulds, C. B.. AU - Williamson, G.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - A 4-hydroxy-3-methoxycinnamic acid (ferulic acid) esterase has been purified from the extracellular broth of cultures of Streptomyces olivochromogenes after growth on oat spelt xylan. The purification procedure utilizes ion exchange on DEAE-BioGel A, anion exchange on Mono Q, gel filtration and hydrophobic interaction chromatography. The purified enzyme appeared as a single band on SDS-PAGE, with an apparent M(r) of 29000. Two bands, at pI 7.9 and 8.5, were observed on isoelectric focusing. With methyl ferulate as substrate, the pH and temperature optima were 5.5 and 30°C respectively, with a K(m) of 1.86 mM and V(maX) of 0.3 μmol min-1 mg-1. The purified enzyme released ferulic acid from de-starched wheat bran only in the presence of xylanase.. AB - A ...
Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response | Journal of...
Inflammatory activation plays a vital role in the pathophysiological mechanisms of stroke, exerting deleterious effects on the progression of tissue damage and may lead to the vascular damage in diabetes. The objectives of this study were to determine the effects of rosmarinic acid (RA) on a cultured neuronal cell line, SH-SY5Y in vitro and experimental ischemic diabetic stroke in vivo. For oxygen-glucose deprivation (OGD) and tumor necrosis factor-α (TNF-α) stimulated SH-SY5Y cell line in vitro, SH-SY5Y cells were incubated with RA. For an in vivo experiment, diabetic rats were subjected to middle cerebral artery occlusion (MACO) for 40 minutes followed by reperfusion for 23 h. Treatment of SH-SY5Y cells with RA reduced the OGD-induced apoptosis and cytotoxicity, blocked TNF-α-induced nuclear transcription factor κB (NF-κB) activation, and decreased high-mobility group box1 (HMGB1) expression. At doses higher than 50 mg/kg, RA produced a significant neuroprotective potential in rats with ischemia
Phytochemicals rosmarinic acid, ampelopsin, and amorfrutin-A can modulate age-related phenotype of serially passaged human skin...
One of the aims of the EU-funded Research and Innovation Action (RIA), titled Ageing with Elegans (AwE) is to enhance better understanding of the factors causing health and disease in aging and develop evidence-based preventive, diagnostic, therapeutic, and other strategies. The work package-5 of this project is focused on testing the effects of phytochemicals of natural and synthetic origin on aging, longevity, and health of human cells in vitro, after the initial screening using the animal model systems of nematodes and rats and mice. Accordingly, the first series of three compounds, rosmarinic acid (ROSM), ampelopsin (AMPEL), and amorfrutin-A (AMOR), were selected to test for their short-term and long-term effects on human skin fibroblasts undergoing aging and senescence in vitro. The lifelong modulatory effects of these compounds were tested individually at two doses (0.5 and 1.0 mu M), selected after a short-term dose response check of a 20,000-fold range (0.01-200 mu M). The results show ...
The comparative study of the medical action of lyuteolin, rosmarinic acid and echinochrom A at experimental stress-induced...
Abstract: The method of the physical load in condition of the coronary circulation of the blood disturbance, caused mesaton injection, induced development rat cardiopathology, bring about of the heart function decompensation and 40% death of experimenthal animals. Under electronic-microscopic study of rat cardiomyocytes are discovered signs to disorganizations of mitochondrial apparatus of these cells. Administration to therapeutic mode of luteolin and echinochrome A preparations has provided to 100% animal probability of survival. At the same time, mitochondrial apparatus of cardiomyocytes was characterized by the normal parameter i.e. given preparations have provided of defensive adative effect at cardiomyocytes level. Similar activities for rosmarinic acid have not shown. Study some metabolic parameter and endocrine status animal has also allowed revealing of therapeutic effect of luteolin and echinochrome A.Findings be evidence of that echinochrome А and luteolin capable to play the ...
Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee - Full Text View - ClinicalTrials.gov
Healthy adults with a clinical diagnosis of osteoarthritis of the knee will be recruited and will undergo a brief phone screening interview, followed by a detailed in-person screening process, to determine study eligibility.. Eligible participants will be matched according to sex, baseline pain according to the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, and duration of osteoarthritis. Participants will then be randomly assigned to receive either the investigative high rosmarinic acid spearmint tea or a comparable placebo mint tea.. During the 4-month treatment period, participants will consume two cups (300 mL in the morning and 300 mL in the evening) of either the high rosmarinic acid spearmint tea (approximately 300 mg rosmarinic acid per day) or the commercial spearmint tea (approximately 20 mg of rosmarinic acid per day) daily.. Data collection will occur at baseline (week 0), mid-treatment (week 8), post-treatment (week 16), and follow-up (week 20). Outcome ...
ChemIDplus - 20283-92-5 - DOUMFZQKYFQNTF-WUTVXBCWSA-N - Rosmarinic acid - Similar structures search, synonyms, formulas,...
20283-92-5 - DOUMFZQKYFQNTF-WUTVXBCWSA-N - Rosmarinic acid - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit
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Mesoionic Oxatriazoles (MOTA): NO-Donating Characteristics and Pharmacology | Bentham Science
Title: Mesoionic Oxatriazoles (MOTA): NO-Donating Characteristics and Pharmacology. VOLUME: 8 ISSUE: 3. Author(s):R. J. Gryglewski, E. Marcinkiewicz, J. Robak, Z. Michalska and J. Madej. Affiliation:Chair of Pharmacology,Medical College of Jagiellonian University, 31531Krakow, Grzegorzecka16, Poland. Keywords:Mesoionic Oxatriazoles, sodium nitroprusside, Sulphonamides, sydnonimine, anti-aggregatory agents, vasorelaxant, 5-phosphodiesterase inhibitor. Abstract: Biological role of nitric oxide (NO), functioning of isoforms of NO synthetases (NOS) and pharmacology of principle NO-donors were reviewed. NO donating characteristics and pharmacology of 23 mesoionic oxatriazoles (MOTA) were compared with those of 5-morpholinosydnonimine (SIN-1), S-nitroso-N-acetylpenicillamine (SNAP), sodium nitroprusside (NaNP) and glyceryl trinitrate (GTN). It is concluded that in vitro NO donating profile of MOTA hardly can be used as a predicting measure for their pharmacological activities either in vitro or in ...
Peroxynitrite Scavenging Activity of Sinapic Acid (3,5-Dimethoxy-4-hydroxycinnamic Acid) Isolated from Brassica juncea
Rosmarinic acid | GreenMedInfo | Substance | Natural Medicine
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Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures. To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems, we conducted this experiment with 2 mM FA. Much higher cytotoxicity was found for 3D- than 2D-culture, showing (2D vs. 3D): apoptotic rates, 64% and 76%; cell killing rates, |svg style=vertical-align:-0.1638pt;width:68.662498px; id=M1 height=15.9 version=1.1 viewBox=0 0 68.662498 15.9 width=68.662498 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg||g transform
ID PHPHP1 preliminary; circular DNA; SYN; 3818 BP. XX AC IG0168; K01193; X01385; XX DT 02-NOV-1992 (Rel. 7, Created) DT 01-JUL-1995 (Rel. 12, Last updated, Version 1) XX DE E. coli phagemid vector pHph+1 - complete. XX KW cloning vector. XX OS Cloning vector OC Artificial sequences; Cloning vehicles. XX RN  RC pHph+1 RA Muller A., Piepersberg W.; RT ; RL Submitted (08-AUG-1989) by: RL Muller A., Inst. fur Biochemie, Darmstadt, Germany. XX RN  RC pHph-1, pHph+1 from pUC9 & hygromycin resistance gene RA Muller A., Piepersberg W.; RT ; RL Unpublished (1984). XX CC old Boehringer vector. CC NM (pHph+1) CC CM (yes) CC NA (ds-DNA) CC TP (circular) CC ST () CC TY (phagemid) CC SP () CC HO (E.coli K-12) CC CP () CC FN (promoter analysis) CC SE () CC PA (pUC8)(pJHPH) CC BR (pHph0)(pHph-1) CC OF () CC OR () XX FH Key Location/Qualifiers FH FT misc_feature 0..0 FT /note=1. E. coli 1142bp, hyg gene FT -, pJHph FT 1. pUC12 remove EcoRI-BamHI 18bp 231..249, MCS/2662bp FT 2. pJHph 1142bp 220..1362, hyg ...
Is there a hygromycin marker in pGIPZ, pTRIPZ, and pLemiR and can it be used for selection?
There is a hygromycin marker on the pGIPZ, pTRIPZ, and pLemiR vectors. It was present on the parent plasmid that they were constructed from but its function has never been tested in house. The hygromycin in the TRIPZ vector was specifically inactivated so it will not work. In theory you could use the hygromycin marker for selection of cells transfected with the pGIPZ or pLemiR plasmid but the hygromycin takes longer to have the desired effect than puromycin. You would not be able to use hygromycin for selection of transduced cells because only what is between the LTRs of the vectors would be packaged and the hygromycin marker lies outside of the LTRs ...
GST4 - Glutathione S-transferase 4 - Zea mays (Maize) - GST4 gene & protein
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides. Most active with substrates possessing a chloroacetamide structure. Trans-cinnamic acid and 1-chloro-2,4-dinitrobenzene are not effective substrates. May play an important role in the benoxacor-mediated protection of maize from metolachlor injury.
pORF39-Hph from InvivoGen
pORF39-Hph from InvivoGen,Hygromycin resistance gene (hph), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin.,biological,biology supply,biology supplies,biology product
2V6.11 [JHU-67] ATCC ® CRL-2784™ Homo sapiens kidney
This line was derived from the human embryonic kidney line, 293 in 2001. 293 cells were transfected with the plasmid pVgRXR bearing a Zeocin-resistance selectable marker to obtain 293VgRXR cells. This population was subsequently transfected with the plasmid pEKORF6 containing Ad5 E4 ORF 6 that encodes E4 34K. pEKORF6 is a derivative of the plasmid pIndHydro that contains a hygromycin resistance gene. The vectors contain SV40 viral DNA sequences. The 2V6.11 cell line was originally selected in hygromycin-containing medium and cloned by single-colony isolation with a cloning cylinder. The 2V6.11 cells inducibly express the human adenovirus E4, 34kDa protein (E4 ORF6). 2V6.11 cells exhibit little or no constitutive E4 biologic activity. Induction by ponasterone A, an ecdysone analog, however, results in E4 biologic activity and levels of E4 34kDa protein that are detectable by immunoblotting. These cells can be used as a tool to study the biology of the adenoviral E4 oncoprotein.
Mesoionic heterocycles and heterocyclic betaine cations (review) | SpringerLink
The first part of this review is devoted to correlation of the data of five foreign reviews and the original research and data of the author on the synthesis of mesoionic heterocycles that do not...
mhpA - 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase - Escherichia coli (strain K12) - mhpA gene & protein
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
Cinnamic acid | ENCOGNITIVE.COM
The antioxidant activity of different extracts of aerial parts of Otostegia persica (Bu-rm.) Boiss., Labiateae were evaluated using b-carotene bleaching and lipid pero-xidation models. The inhibi.... ...
cinnamic acid (CHEBI:27386)
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Simple Accordion with CSS & jQuery by Soh Tanaka
In a 500-cc. flask, fitted with a 24-cm. fractionating column (Note 1) and (Note 2) attached to a water-jacketed condenser, are placed 148 g. (1 mole) of dry powdered cinnamic acid, 2 g. of hydroquinone, and several small pieces of clay plate. One-half gram of hydroquinone is also placed in the flask in which the distillate is to be collected (Note 3). The acid is rapidly heated over a wire gauze with a free flame until phenylethylene begins to distil, the heating being regulated so that the temperature of the vapors at the head of the column never exceeds 130°, and mainly remains below 120° (Note 4) and (Note 2). The cinnamic acid refluxes, but very little should escape and collect in the condenser. The decomposition is complete in three and one-half to five hours, when no more phenylethylene distils and the temperature at the head of the column rises rapidly ...
Mathilde Glutathione Shea Butter Soap - Quelth
Reduces Inflammation: A 2010 study found that due to its cinnamic acid and other natural properties, shea butter was anti-inflammatory. One compound in particular, lupeol cinnamate, was found to reduce skin inflammation and even potentially help avoid skin mutations. This also makes it beneficial for some people with acne ...
Establishing stabel cell lines
We are trying to establish two stable cell lines using G418 resistance and hygromycin resistance. After determining the concentration of each drug needed to kill the cells, we proceeded with transfections. Some of the control cells (approx. 30%), those transfected with no DNA, did not die. Has anyone encountered this problem before? If so, what actions did you take? Could you still establish a stable cell line? Thanks. http://biowww.net/mynews/tree.php?group_name=bionet_immunology&begin=0 ...
pCEP4 Sequence and Map
Episomal mammalian vector with a CMV promoter and a hygromycin resistance marker, for high-level expression in primate and canine cells.
Hygromycin B | Selection Antibiotic | InvivoGen
Hygromycin B solution is a selection antibiotic for mammalian and bacterial cells. It is sterile, cell culture tested, and available as a solution. CAS 31282-04-9
September | 2015 | CD177 Signaling
he number of DEGs that could be assessed by IPA, we re filtered the TSA and CBHA responsive DEGs through more stringent statistical criteria. We set Temsirolimus msds an absolute 2. 5 fold change and p value of 0. 01 for TSA responsive genes, similarly, CBHA responsive genes were re filtered through an absolute 3. 5 fold change and a p value of 0. 01. These statistical maneuvers reduced TSA regulated genes to 157 and 114, at 6h and 24h post treatment. Of these, 52 genes were up regulated at 6h and 104 genes down regulated. At 24h treat ment 52 genes were up regulated and 62 genes were down regulated. A more stringent statistical analysis yielded 147 and 249 genes for CBHA treatment at 6h and 24h, respectively. At 6h treatment of CBHA 82 genes were up regulated and 65 genes down regulated.. At 24h treatment 90 genes were up regulated and 159 genes were down regulated. The initial analysis of the merged datasets by IPA revealed that although CBHA and TSA elicited unique signatures of gene ...
Rosmarinic acid - The active ingredient from rosemary
osmarinic acid is a primary ingredient of Perilla Oil, an oil that is a part of traditional Japanese Kampo medicine known as Saiboku-To. The use of Saiboku-To has proven effective in treating allergies in research studies (1-3).. Rosmarinic acid has shown antioxidant effects in vitro against superoxide radicals and hydroxyl radicals (4). Rosmarinic acid can also prevent the oxidation of LDL molecules, and has shown synergy with lycopene (5).. A 2004 study showed the effect of rosmarinic acid on seasonal allergic rhinoconjunctivitis and the resulting inflammatory allergic response that comes with this condition (6). Over 21 days patients who supplemented with rosmarinic acid had significantly reduced symptoms when compared to the placebo group. The same group conducted an animal study at the same time and concluded that rosmarinic acid was able to reduce inflammation via an antioxidant effect as well as by directly inhibiting the inflammatory response.. In the same year a further study on ...
Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator | Science...
Quorum sensing is a bacterial communication mechanism that controls genes, enabling bacteria to live as communities, such as biofilms. Homoserine lactone (HSL) molecules function as quorum-sensing signals for Gram-negative bacteria. Plants also produce previously unidentified compounds that affect quorum sensing. We identified rosmarinic acid as a plant-derived compound that functioned as an HSL mimic. In vitro assays showed that rosmarinic acid bound to the quorum-sensing regulator RhlR of Pseudomonas aeruginosa PAO1 and competed with the bacterial ligand N-butanoyl-homoserine lactone (C4-HSL). Furthermore, rosmarinic acid stimulated a greater increase in RhlR-mediated transcription in vitro than that of C4-HSL. In P. aeruginosa, rosmarinic acid induced quorum sensing-dependent gene expression and increased biofilm formation and the production of the virulence factors pyocyanin and elastase. Because P. aeruginosa PAO1 infection induces rosmarinic acid secretion from plant roots, our results ...
Molecular Sequelae of Histone Deacetylase Inhibition in Human Retinoblastoma Cell Lines: Clinical Implications | IOVS | ARVO...
purpose. To characterize the molecular sequelae induced in retinoblastoma (Rb) cells by histone deacetylase inhibitors (HDACIs). Hydroxamic acid-based HDACIs such as vorinostat (suberoylanilide hydroxamic acid) induce the differentiation and apoptosis of transformed cells. Vorinostat has demonstrated significant anticancer activity against hematologic and solid tumors at doses well tolerated by patients and has been approved for the treatment of patients with cutaneous T-cell lymphoma.. methods. The authors evaluated the effects of the HDACIs vorinostat and m-carboxycinnamic acid bis-hydroxamide on the Rb cell lines Y79 and WERI-Rb1 with the use of the MTT assay, BrdU incorporation assay, flow cytometry, immunoblotting, gene-expression profiling, quantitative RT-PCR, and NF-κB DNA-binding assay.. results. Both HDACIs were effective against both Rb cell lines, inducing growth arrest and apoptosis in vitro. Vorinostat increased p53 expression and activated caspases -8, -9 and -3, whereas caspase ...
Rosmarinic acid biochemical activities | Medicine raw materials
Rosmarinic acid is a actinic admixture begin in a array of plants. It has antioxidant properties. Rosmarinic acid is a abeyant anxiolytic as it acts as a GABA transaminase inhibitor, added accurately on 4-aminobutyrate transaminase. Rosmarinic acid aswell inhibits the announcement of indoleamine 2,3-dioxygenase via its cyclooxygenase-inhibiting properties. Senescent leaves of Heliotropium foertherianum (Boraginaceae) aswell…
IJMS | Free Full-Text | Neuroprotective Properties of Picroside II in a Rat Model of Focal Cerebral Ischemia
The aim of this study was to explore the effect of picroside II on neuronal apoptosis and the expression of caspase-3 and poly ADP-ribose polymerase (PARP) following middle cerebral artery occlusion/reperfusion in male Wistar rats. Picroside II (10 mg/kg) was administered intravenously into the tail vein of the animals. The neurological function deficits were evaluated with the Bedersons test and the cerebral infarction volume was visualized with tetrazolium chloride (TTC) staining. The apoptotic cells were counted by in situ terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) assay. The immunohistochemistry stain and enzyme linked immunosorbent assay (ELISA) was used to determine the expressions of caspase-3 and PARP in brain tissue. The results indicated that rats in the control group showed neurological function deficit and cerebral infarction in ischemic hemisphere after two hours ischemia followed by 22 hours reperfusion. Caspase-3 and
Dihydrocodeinone bitartrate | definition of dihydrocodeinone bitartrate by Medical dictionary
Looking for online definition of dihydrocodeinone bitartrate in the Medical Dictionary? dihydrocodeinone bitartrate explanation free. What is dihydrocodeinone bitartrate? Meaning of dihydrocodeinone bitartrate medical term. What does dihydrocodeinone bitartrate mean?
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Accumulation of tilianin and rosmarinic acid and expression of...
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Accumulation of tilianin and rosmarinic acid and expression of phenylpropanoid biosynthetic genes in Agastache rugosa.
Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK
Skeletal muscle is a major insulin-target tissue and plays an important role in glucose homeostasis. Impaired insulin action in muscles leads to insulin resistance and type 2 diabetes mellitus. 5′ AMP-activated kinase (AMPK) is an energy sensor, its activation increases glucose uptake in skeletal muscle and AMPK activators have been viewed as a targeted approach in combating insulin resistance. We previously reported AMPK activation and increased muscle glucose uptake by rosemary extract (RE). In the present study, we examined the effects and the mechanism of action of rosmarinic acid (RA), a major RE constituent, in L6 rat muscle cells. RA (5.0 μM) increased glucose uptake (186 ± 4.17% of control, p , 0.001) to levels comparable to maximum insulin (204 ± 10.73% of control, p , 0.001) and metformin (202 ± 14.37% of control, p , 0.001). Akt phosphorylation was not affected by RA, while AMPK phosphorylation was increased. The RAstimulated glucose uptake was inhibited by the AMPK inhibitor ...
NOPR: Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ
FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly ...
CHARACTERIZATION OF PHENOLIC ACIDS PROFILE FROM CHILEAN RED WINES BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
In plants, benzoic and cinnamic acids derivatives are physically dispersed throughout seeds, leaves, roots, and tems13. Their roles in plants are many, including nutrient uptake, protein synthesis, enzyme activity, photosynthesis, structural components, and allelopathy 14-16.. Growing interest in phenolic acids is partly due to their potential activity as protective factors against human diseases such as cancer, heart ailments, and HIV, and partly because of their potent antioxidant capacity1721. Although it is possible that all the properties described for red wines are the effect of mixture of compounds, more than the effect of just one type of compound4. At the same time phenolic acids receive special, attention because of their ubiquitous presence in plant-based foods, leading to their daily human consumption22. Furthermore, the role play the phenolic acids in the organoleptic properties of foods (flavor, astringency, etc.) has led to increasing analytical studies23.. In wine, phenolic acid ...
EMEA (Europe, Middle East and Africa) 2-Chlorocinnamic Acid Market Report 2018
Refined Petroleum Product Market in Argentina to 2022. The report Refined Petroleum Product Market in Argentina to 2022 offers the most up-to-date industry data on the actual market situation, and future outlook for refined petroleum products in Argentina. The research includes historical data from 2011 to 2017 and forecasts until 2022 which makes the report an invaluable resource .... February 2018 , $611 ,View Details>> ...
Universität Düsseldorf: pMF1-hs with hygromycin resistance cassette
Lab ID pUMa194 (short hyg promoter version), published as pBS-hhn, this plasmid was not developed in our lab (this plasmid is easier to use than the original, larger plasmid pMF1-h Brachmann et al., 2004 ...
TCDB » SEARCH
9.C.8 The ABC Lignin Precursor Transporters (ALPT) Family. Lignin is a complex biopolymer derived primarily from the condensation of three monomeric precursors, the monolignols. The synthesis of monolignols occurs in the cytoplasm. To reach the cell wall where they are oxidized and polymerized, they must be transported across the cell membrane. Using isolated plasma and vacuolar membrane vesicles prepared from Arabidopsis, together with applying different transporter inhibitors in the assays, Miao and Liu (2010) examined the uptake of monolignols and their derivatives by these native membrane vesicles. They demonstrated that the transport of lignin precursors across plasmalemma and their sequestration into vacuoles are ATP-dependent primary-transport processes, involving ATP-binding cassette-like transporters. Moreover, both plasma and vacuolar membrane vesicles selectively transported different forms of lignin precursors. In the presence of ATP, the inverted plasma membrane vesicles ...
GMD - Sinapic acid, trans- - InChI=1S/C11H12O5/c1-15-8-5-7(3-4-10(12)13)6-9(16-2)11(8)14/h3-6,14H,1-2H3,(H,12,13)/b4-3+
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
Amyl cinnamate - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 3487-99-8(amyl cinnamate),please inquire us for 3487-99-8(amyl cinnamate).
A mesoionic nitrogen-donor ligand: structure, iridium coordination, and catalytic effects - Dalton Transactions (RSC Publishing)
A mesoinic pyridylideneamide ligand (PYA) was synthetized and fully characterized and coordinated to an iridium(iii) center. This ligand represents the first example of a mesoionic N-donor ligand. Structural and spectroscopic analysis revealed unique properties which were exploited in chemically driven water oxidat
2-methyl-2-adamantyl) prop-2-enoate 249562-06-9 H-NMR | C-NMR Spectral Analysis NMR Spectrum
(2-methyl-2-adamantyl) prop-2-enoate 249562-06-9 NMR spectrum, (2-methyl-2-adamantyl) prop-2-enoate H-NMR spectral analysis, (2-methyl-2-adamantyl) prop-2-enoate C-NMR spectral analysis ect.
1-adamantyl 2-(trifluoromethyl)prop-2-enoate 188739-82-4 H-NMR | C-NMR Spectral Analysis NMR Spectrum
1-adamantyl 2-(trifluoromethyl)prop-2-enoate 188739-82-4 NMR spectrum, 1-adamantyl 2-(trifluoromethyl)prop-2-enoate H-NMR spectral analysis, 1-adamantyl 2-(trifluoromethyl)prop-2-enoate C-NMR spectral analysis ect.
cDNA cloning and heterologous expression of coniferin β-glucosidase, Plant Molecular Biology | 10.1023/A:1006226931512 |...
Read cDNA cloning and heterologous expression of coniferin β-glucosidase, Plant Molecular Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils
The most potent activators of ROS production in mitochondria are phenolic acids whose effect is mediated via the interaction with thiol groups. Among these are benzoic and cinnamic acids. Some phenolic acids, in particular phenyllactate and p-hydroxyphenyllactate, which decrease ROS production in mi …
Inflammatory diseases are due to abnormal immune system responses and so are seen as a an imbalance of inflammatory mediators...
Inflammatory diseases are due to abnormal immune system responses and so are seen as a an imbalance of inflammatory mediators and cells. review can be to go over the anti-inflammatory ramifications of RosA in inflammatory illnesses and its root mechanism. and research possess reported the anti-inflammatory ramifications of RosA in inflammatory illnesses. This review systematically identifies the restorative potential of RosA for inflammatory illnesses and discusses its likely mechanisms. Open up in another window Shape 1 The framework of RosA. Aftereffect of Rosmarinic Acid solution on ICG-001 ic50 Inflammatory Illnesses Arthritis Arthritis can be an inflammatory disease which involves damage to a number of joints. They have several hundred types, the most frequent which are osteoarthritis and arthritis rheumatoid (Petchi et?al., 2013). Osteoarthritis (OA) can be a intensifying degenerative disease seen as a inflammation from the synovial, scratching from the cartilage surface area, subchondral ...
Synthesis, characterization and tubulin-interaction profile of substituted cinnamoyl urea derivatives| Abstract
Substituted cinnamoyl ureas have been identified as novel compounds with their various biological acti vities. The novel cinnamoyl ureas were synth..
DNASU Plasmid | Detailed...
Mycoplasma coexpression expression vector with the Phsp promoter and C-termial c-myc tag; newer version of pMYC4-H suitable for universal cloning by PacI and SbfI sites; hygromycin resistance in bacteria and mycobacteria; restriction enzyme cloning (PacI, SbfI ...
The phenolic compound used in this study is p-coumaric acid, which is the derivative of phenolic acid playing a role in giving color, odor and taste to the plants. The p-coumaric acid is an organic compound derived from ...
1-Adamantanecarboxylic acid, 2-adamantyl ester | C21H30O2 - PubChem
1-Adamantanecarboxylic acid, 2-adamantyl ester | C21H30O2 | CID 585141 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Effect of phytobacteriomycin, trichotecin, hygromycin B and levoristatin on some rat liver enzymes]. - Semantic Scholar
In experiments with albino rats it was found that after administration of phytobacteriomycin, trichotecin, hygromycin B or levoristatin into the stomach in doses of 1/20 of LD50 activity of the microsomal enzymes of the liver cells significantly changed and the changes persisted within at least 2 weeks. The above antibiotics induced similar changes in the lysosome enzyme, i.e. acid phosphatase, providing an increase in its activity. Changes in the activity of succinate dehydrogenase (mytochondria indicator enzyme), glucose-6-phosphatase (ribosome indicator enzyme) and aspartate aminotransferase (cytoplasm indicator enzyme) were different for each antibiotic. It is concluded that the above antibiotics were capable of impairing on intoxication the enzymatic function of various cell microstructures, though the levels of the change direction may be different.
trans-2-Hydroxycinnamic acid, methyl ester
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Chemistry Now: Computational Chemistry | Resource | RSC Education
A case study of the development of derivatives of cinnamic acid as a repellent to dissuade birds from eating crops treated with it.
Acrobat Plus WG
Dimethomorf (Dimethomorph) 90 g/kg (SkupinyGroups: cinnamic acid amides), Mankozeb (Mancozeb) 600 g/kg (SkupinyGroups: dithio-carbamatesand relatives) ...
p-coumaric acid-loaded Ni-carbonate nanovalve
Page contains details about p-coumaric acid-loaded Ni-carbonate nanovalve . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Raw Shea Butter- Handcrafted, Unrefined Jar - Shearadiance
We gently mixed 100% Natural and unrefined Shea Butter to make it softer and easier to apply. This is pure unrefined Shea Butter with a smoother texture filled with all the healing benefits of the shea nut.
Tree Hut Original Shea Body Butter Original Shea Reviews Page 11
Before you buy Tree Hut Original Shea Body Butter Original Shea, check out 199 Influenster reviews. Sakeeina D. said This product is just super super...
Shea Butter Extra Gentle Soap - LOccitane | Sephora
What it is:A gentle cleanser enriched with shea butter to nourish and soothe skin. What it does:Rich in softening and protective shea butter, this soaps foamy lather gently cleanses the skin, while preserving its natural moisture balance. The 100 pe
NYFW -The look at LaQuan Smith by Shea Moisture - BEAUTYLICIOUS LIFESTYLE
One show I definitely look forward to attending next season is LaQuan Smith. All of the looks were strong ,sexy and wearable off the runway . For those who crave style this line will never disappoint. To fit in with the theme of confident and strong Shea Moisture the team was on hand to create…
Ethyl cinnamate is a common example. Reduction of the carboxylic acid functional groups in the cinnamic acids provides the ... Hydroxylation of cinnamic acid in the 4-position by trans-cinnamate 4-monooxygenase leads to p-coumaric acid, which can be ...
"Enantioselective Catalytic Epoxidation of Cinnamate Esters". Tetrahedron. 50 (15): 4323-4334. doi:10.1016/S0040-4020(01)89369-8 ...
Clifford M (1999). "Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden". J. Sci. Food Agric. 79 (3 ...
The analysis and characterization of chlorogenic acids and other cinnamates". In Santos-Buelga, C.; Williamson, G. (eds.). ... Clifford, M. N. (1999). "Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden". Journal of the ...
Plicatin A and B, two phenolic cinnamates from Psoralea plicata. Nazli Rasool, Abdul Qasim Khan and Abdul Malik, Phytochemistry ...
For methyl cinnamate, the two substituents (Ph v.s. COOMe) compete at withdrawing electrons from the alkene. The carboxyl is ... For example, consider the cycloaddition of diazomethane to three dipolarophiles: methyl acrylate, styrene or methyl cinnamate. ...
Shea nut and butter production in Burkina Faso
"Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat". Journal of Oleo Science. 59 ...
Another population is rich in methyl cinnamate with two chemotypes. Melaleuca viridiflora is a useful and adaptable small tree ...
Ethyl cinnamate cinnamon Ethyl formate lemon, rum, strawberry Ethyl heptanoate apricot, cherry, grape, raspberry ...
Asymmetric nucleophilic epoxidation
Lanthanide-mediated epoxidation has been successfully applied to cinnamates and β-heteroaryl unsaturated esters. Amides are ...
It is a derivative of hydroxycodeinone, being the 14-cinnamate ester. In another paper, Buckett assigns the potency as 177 with ...
It contains methyl cinnamate, giving it a flavor reminiscent of cinnamon. Cinnamon basil has somewhat narrow, slightly serrated ...
Brettanomyces converts this to 4-vinylphenol via the enzyme cinnamate decarboxylase. 4-Vinylphenol is further reduced to 4- ...
The same study of methyl cinnamate did not show this effect. It has also been shown that this oil can reduce the chance of ... The taste of Ecuadorian cinnamon is thought to come from the presence of methyl cinnamate and trans-cinnamaldehyde which are ...
The yeast converts this to 4-vinylphenol via the enzyme cinnamate decarboxylase. 4-Hydroxycinnamate decarboxylase can also be ...
The second mechanism involves two cinnamate units coupled together by malonyl-CoA. Both use cinnamic acid as their starting ...
revealed the major chemical component of this species fragrance is trans-methyl cinnamate. Closely related species are ...
Among other substances, males of this species are attracted by methyl cinnamate baits. The Ancient Greek, ...
Related flavouring compounds are tetrahydrofurfuryl butyrate, tetrahydrofurfuryl cinnamate, tetrahydrofurfuryl alcohol, and ...
Mizutani, M.; Ohta, D.; Sato, R. (1997). "Isolation of a cDNA and a genomic clone encoding cinnamate 4-hydroxylase from ... A deamination reaction then produces trans-cinnamate, which undergoes hydroxylation to form 4-coumarate. Acetyl-CoA is then ...
The enzyme cinnamate decarboxylase catalyzes the conversion of p-coumaric acid into 4-vinylphenol. Vinyl phenol reductase then ...
... trans-cinnamate-forming). Previously, it was designated EC 126.96.36.199, but that class has been redesignated as EC 188.8.131.52 ( ... then expels ammonia to form the cinnamate alkene. The mechanism of the reaction of PAL is thought to be similar to the ...
The leaf oil is 98% methyl cinnamate and yield is 2-6% of fresh leaf weight. The leaf of E. olida leaf is also used as a dried ... E. olida juvenile foliage Methyl cinnamate extracted from Eucalyptus olida Leaves of Eucalyptus olida in small steam ...
... with use of cinnamate 4-hydroxylase (C4H). 4-coumarate:CoA ligase (4CL) is then used to get p-Coumaroyl-CoA (5). P-Coumaroyl ...
These photo-resistant resins are formed from cinnamic acid esters, with the most preferable being polyvinyl cinnamate. While ...
... methyl cinnamate and geranyl acetate. The cineole-based oil is used as component in pharmaceutical preparations to relieve the ... methyl cinnamate Eucalyptus radiata - phellandrene variant Eucalyptus staigeriana - citral, limonene The former lemon ...
Five compounds, (Z)− and (E)−methyl cinnamates, (Z)− and (E)−ethyl cinnamates, and geranyl acetate, were identified for the ... The amount of davanone and linalool decreased while those of (Z)− and (E)−methyl cinnamate, (E)−ethyl cinnamate, ... Methyl cinnamate, ethyl cinnamate, bicyclogermacrene, 2-hydroxyisodavanone, farnesol, geranyl acetate, sesquiterpene lactones, ...
Chlorogenic acids and other cinnamates. Nature, occurrence and dietary burden. J. Sci. Food. Agric. (79) 362-372, 1999 ...
... cinnamate and (R)-phenyllactyl-CoA. This enzyme belongs to the CoA-transferase family. The systematic name of this enzyme class ... cinnamate + (R)-phenyllactyl-CoA Thus, the two substrates of this enzyme are (E)-cinnamoyl-CoA and (R)-phenyllactate, whereas ... cinnamate by Clostridium sporogenes". Eur. J. Biochem. 267 (12): 3874-84. doi:10.1046/j.1432-1327.2000.01427.x. PMID 10849007. ...
Winter Stick SPF 15 | Sunblock Ad Wind Protection - the JTree Life
Cinerary urn | Article about cinerary urn by The Free Dictionary
- Benzyl cinnamate is the chemical compound which is the ester derived from cinnamic acid and benzyl alcohol. (wikipedia.org)
- Methyl cinnamate is the methyl ester of cinnamic acid and is a white or transparent solid with a strong, aromatic odor. (wikipedia.org)
- Isoamyl cinnamate, also known as fema 2063, belongs to the class of organic compounds known as cinnamic acid esters. (foodb.ca)
- Potassium cinnamate is natural cinnamic acid potassium salt, is also a new product in the field of food preservatives, non-toxic harmless to the human body, safe and convenient, but also on the human body has a variety of health functions, so it is a great development and application prospects, it has caused the emergence of food preservative industry shock. (manodehotel.com)
- 2019-6-3 · Potassium cinnamate is natural cinnamic acid potassium salt, is also a new product in the field of food preservatives, non-toxic harmless to the human body. (manodehotel.com)
- Cinnamate-4-hydroxylase (C4H) converts trans-cinnamic acid (CA) to p-coumaric acid (COA) in the phenylpropanoid/lignin biosynthesis pathway. (openaire.eu)
Expression of cinnamate 4-hydroxylase1
- Functional expression of cinnamate 4-hydroxylase from Ammi majus L. (semanticscholar.org)
- Examples include cinnamates, salicylates and benzophenones. (mayoclinic.org)
- Cinnamyl cinnamate (CAS 122-69-0) Market Research Report 2018 aims at providing comprehensive data on cinnamyl cinnamate market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
- It captures cinnamyl cinnamate market trends, pays close attention to cinnamyl cinnamate manufacturers and names suppliers. (marketpublishers.com)
- Besides, the report provides cinnamyl cinnamate prices in regional markets. (marketpublishers.com)
- In addition to the above the report determines cinnamyl cinnamate consumers. (marketpublishers.com)
- Cinnamyl cinnamate (CAS 122-69-0) Market Research Report 2018 contents were prepared and placed on the website in February, 2018. (marketpublishers.com)
- Please note that Cinnamyl cinnamate (CAS 122-69-0) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
- Hence, the goal of this study was to identify the genetic association among SNPs from Cinnamate 4-Hydroxylase (C4H) and Cinnamyl Alcohol Dehydrogenase (CAD) genes and an array of wood properties namely, specific gravity, wood density, fiber-length, cell wall thickness and microfibril angle from Acacia mangium Superbulk trees. (unimas.my)
Balsam of P1
- Benzyl cinnamate occurs in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam. (wikipedia.org)
- However, the underlying bioactivity and molecular mechanisms of methyl cinnamate on adipocyte function and metabolism remain unclear. (sigmaaldrich.com)
- Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. (semanticscholar.org)
- The absorption and metabolism of methyl cinnamate. (semanticscholar.org)
Form a unique fingerprint1
- Dive into the research topics of 'A stereoselective route to the sugar-cinnamate unit of Hygromycin A'. Together they form a unique fingerprint. (hw.ac.uk)
- Two cinnamate derivatives produce similar alteration in mRNA expression and activity of antioxidant enzymes in rats. (semanticscholar.org)
- Description:Name: Potassium cinnamate CAS No.: 16089-48-8 Formula: C9H7KO2 Usage: In the international market, Potassium cinnamate is usually used as a raw material for essence and spices.New natural food preservatives, widely used in medicine, agriculture and food. (manodehotel.com)
- otassium cinnamate, as a new kind of natural food preservatives, is widely used in the food field. (landmarkind.com)
- The urinary mercapturic acid excretion by female rats of methyl atropate (alpha-phenyl methyl acrylate) and methyl cinnamate (beta-phenyl methyl acrylate) has been studied. (sigmaaldrich.com)
- Our company is specialized exporter, manufacturer and supplier of Ethyl cinnamate in china. (trader-china.com)
- Potassium Cinnamate, CAS 16089-48-8 manufacturer supplier in China, offering Potassium Cinnamate CAS 16089-48-8 with Best Price, Non-GMO Textured Pea Protein Vegetarian Meat/Textured Pea Protein 80%, Non-GMO Soy Bean Fiber Soy Bean Dietary Fiber for Meat and Sausages Ketchup and so on. (manodehotel.com)
- 17 Hexyl cinnamal cinnamates? (thenakedscientists.com)
- This paper reports the preparation of green pesticides based on nano-hybrids composed of a Layered Double Hydroxide (LDH) with cinnamate anion. (cronogard.com)
- The report then estimates 2016-2021 market development trends of Ethyl Cinnamate industry. (reportsnreports.com)
- Chen, W. 2008-05-15 00:00:00 A novel cinnamate 4-hydroxylase (C4H) gene (designated as SmC4H) involved in the rosmarinic acid biosynthesis pathway is cloned from Salvia miltiorrhiza. (deepdyve.com)
- Cinnamate 4-hydroxylase (C4H) catalyzes the conversion of cinnamate into 4-hydroxy-cinnamate, a key reaction of the phenylpropanoid pathway which leads to the biosynthesis of several secondary metabolites. (oup.com)
- Cinnamates have replaced PABA as the next most potent UVB absorber and include octinoxate (OMC) and cinoxate. (nih.gov)
- Inhibitory effects of methyl trans-cinnamate on mushroom tyrosinase and its antimicrobial activities. (sigmaaldrich.com)
- The ability of Populus C4H isoforms to convert trans -cinnamate into p -coumaric acid was verified by the examination of yeast. (oup.com)
- Subsequent FTIR measurements on irradiated and nonirradiated electrospun fibers indicated both [2π + 2π] cycloaddition of the vinylene C=C and trans-cis photoisomerization of the cinnamate group. (elsevier.com)
- ECHA organiseert raadplegingen om van alle geïnteresseerde partijen feedback te krijgen en om zo breed mogelijke wetenschappelijke informatie te verzamelen voor de regelgevingsprocedures. (europa.eu)
- Three polymers with different mol % of the photoreactive cinnamate functional group (4, 9, and 13 mol %) were synthesized and utilized for this study. (elsevier.com)
- Characterization and expression profiling of cinnamate 4-hydroxylase gene from Salvia. (deepdyve.com)
- Potassium cinnamate can be completely combined with food, will not become a food of allogeneic substances, without changing the original flavor and nutritional structure of food, from the food and the integration of the surrounding environment to achieve anti-corrosion purposes. (landmarkind.com)
- Phenylalanine ammonia lyase in the management of phenylketonuria: the relationship between ingested cinnamate and urinary hippurate in humans. (semanticscholar.org)
- Hot Selling High Quality 16089-48-8 Potassium Cinnamate With Factory Price And F. Name: Potassium cinnamate CAS No.: 16089-48-8 Formula: C9H7KO2 Usage: In the international market, Potassium cinnamate is usual. (manodehotel.com)
- Cinnamates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- Cinnamate is a widespread secondary metabolite of phenolic compound synthesized by plants for defensive purposes. (semanticscholar.org)
- George A. Burdock (2010), "BENZYL CINNAMATE", Fenaroli's Handbook of Flavor Ingredients (6th ed. (wikipedia.org)