A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
A PEPTIC ULCER located in the DUODENUM.
A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Hydrochloric acid present in GASTRIC JUICE.
Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
A family of proteins involved in the transport of organic cations. They play an important role in the elimination of a variety of endogenous substances, xenobiotics, and their metabolites from the body.
Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically.
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.
Gastric analysis for determination of free acid or total acid.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
A histamine H2 receptor antagonist that is used as an anti-ulcer agent.
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.
Facilities equipped to carry out investigative procedures.
Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.
Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.
The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.
Shortened forms of written words or phrases used for brevity.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
Benign epidermal proliferations or tumors; some are viral in origin.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM.
The part of the face above the eyes.
A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.
A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. COUP transcription factors can heterodimerize with a variety of factors including RETINOIC ACID RECEPTORS; THYROID HORMONE RECEPTORS; and VITAMIN D RECEPTORS.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A preparation of chicle, sometimes mixed with other plastic substances, sweetened and flavored. It is masticated usually for pleasure as a candy substitute but it sometimes acts as a vehicle for the administration of medication.

Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. (1/872)

The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine. Nicorandil (3 and 10 mg/kg) given orally to rats dose-dependently inhibited the development of acid-related damage (water-immersion- and aspirin-induced gastric lesions) in the models. Cimetidine (50 mg/kg, p.o.) also had anti-ulcer effects in the same models. However, in the presence of glibenclamide (20 mg/kg, i.v.), an antagonist of K(ATP) channels, nicorandil did not inhibit the formation of gastric lesions. Nicorandil (10 mg/kg) given intraduodenally (i.d.), like cimetidine (50 mg/kg), significantly reduced the volume of the gastric content, total acidity and total acid output in the pylorus ligation model. Glibenclamide reversed the changes caused by i.d. nicorandil. I.v. infusion of nicorandil (20 microg/kg per min) significantly increased gastric mucosal blood flow, without affecting blood pressure and heart rate, but the increase in the blood flow was not observed after i.v. treatment with glibenclamide (20 mg/kg). These results indicate that nicorandil administered orally to rats produces the anti-ulcer effect by reducing the aggressive factors and by enhancing the defensive process in the mucosa through its K(ATP)-channel-opening property.  (+info)

Cimetidine transport in brush-border membrane vesicles from rat small intestine. (2/872)

In previous studies, sulfoxide metabolite was observed in animal and human intestinal perfusions of cimetidine and other H2-antagonists. A sequence of follow-up studies is ongoing to assess the intestinal contributions of drug metabolism and drug and metabolite transport to variable drug absorption. An evaluation of these contributions to absorption variability is carried out in isolated fractions of the absorptive cells to uncouple the processes involved. In this report, data is presented on the drug entry step from a study on [3H]cimetidine uptake into isolated brush-border membrane vesicles from rat small intestine. A saturable component for cimetidine uptake was characterized with a Vmax and Km (mean +/- S.E.M.) of 6.1 +/- 1.5 nmol/30s/mg protein and 8.4 +/- 2.0 mM, respectively. Initial binding, and possibly intravesicular uptake, was inhibited by other cationic compounds including ranitidine, procainamide, imipramine, erythromycin, and cysteamine but not by TEA or by the organic anion, probenecid. Initial uptake was not inhibited by amino acids methionine, cysteine, or histidine, by the metabolite cimetidine sulfoxide, or by inhibitors of cimetidine sulfoxidation, methimazole, and diisothiocyanostilbene-2,2'-disulfonic acid. Equilibrium uptake was inhibited by ranitidine, procainamide, and cysteamine but not by erythromycin or imipramine. Initial cimetidine uptake was stimulated by an outwardly directed H+ gradient, and efflux was enhanced by an inwardly directed H+ gradient. Collapse of the H+ gradient as well as voltage-clamping potential difference to zero significantly reduced initial cimetidine uptake. The data is supportive of both a cimetidine/H+ exchange mechanism and a driving-force contribution from an inside negative proton or cation diffusion potential.  (+info)

Glomerular filtration rate estimation from plasma creatinine after inhibition of tubular secretion: relevance of the creatinine assay. (3/872)

BACKGROUND: Estimation of glomerular filtration rate (GFR) from plasma creatinine concentration after inhibition of tubular creatinine secretion with cimetidine provides a good assessment in patients with various nephropathies and with non-insulin-dependent diabetes mellitus (NIDDM). The aim of this study was to compare cimetidine-aided GFR estimations using various creatinine assays. METHODS: In 30 outpatients with NIDDM GFR was measured as the urinary clearance of continuously infused [125I]iothalamate. Plasma creatinine concentration was analysed after oral cimetidine with an alkaline picrate (AP) method, with an enzymatic (PAP) assay and with HPLC. GFR estimations were calculated with the Cockcroft Gault formula (CG). RESULTS: AP creatinine concentrations were significantly higher than PAP or HPLC values. GFR estimations by AP (CG(AP) 66 +/- 19 ml/min/1.73 m2, mean SD) were significantly lower than GFR (89 +/- 30), whereas CG(PAP) (85 +/- 30) and CG(HPLC) (84 +/- 34 ml/min/1.73 m2) were not. Bland and Altman analysis showed a difference between CG(AP) and GFR of -22.4 +/- 17.7 ml/min/1.73 m2; this difference becomes larger when the GFR increases. The difference between CG and GFR was only -3.8 +/- 14.8 ml/min/1.73 m2 for PAP and -4.4 +/- 17.5 ml/min/1.73 m2 for HPLC, without any systematic difference. CONCLUSION: A good assessment of the GFR from plasma creatinine after cimetidine administration is possible when creatinine is measured with an enzymatic assay or with the less convenient HPLC method. The more widespread and cheaper alkaline picrate assay is not suitable for GFR-estimation.  (+info)

Drug interactions of H2-receptor antagonists involving cytochrome P450 (CYPs) enzymes: from the laboratory to the clinic. (4/872)

This paper reviews the main steps in the research of the interactions of H2-receptor antagonist drugs with cytochrome P450 (CYP) enzymes. Cimetidine, ranitidine, and related compounds are used as examples. The results from in vitro studies are related to the observed clinically significant in vivo drug-drug and drug-chemical interactions. Uses of the in vitro results are discussed for the interpretation and possible prediction of drug-drug interactions, which may be important in developing new drugs. Other approach in the use of the in vitro data is to prevent undesirable and toxic actions of drugs related to the catalytic activity of CYP enzymes. In the case of H2-receptor antagonists, the inhibition of the metabolic reactions due to the binding of the drugs with the enzymes was used to avoid side effects of co-administered drugs. The in vitro metabolic studies using recombinant human as well as animal CYP enzymes are now widely used as model syste ms for designing new drugs with improved therapeutic properties.  (+info)

Histamine response and local cooling in the human skin: involvement of H1- and H2-receptors. (5/872)

AIMS: Histamine may contribute locally to cutaneous blood flow control under normal and pathologic conditions. The objective of this study was to observe the influence of skin temperature on histamine vasodilation, and the roles of H1-and H2-receptors using novel noninvasive methods. METHODS: Eleven healthy subjects received, double-blind, single doses of the H1-receptor antagonist cetirizine (10 mg), cetirizine (10 mg) plus the H2-receptor antagonist cimetidine (400 mg), or placebo on separate occasions. Histamine was dosed cumulatively by iontophoresis to the forearm skin at 34 degrees C and 14 degrees C. Laser-Doppler flux (LDF) was measured at the same sites using customised probeholder/iontophoretic chambers with Peltier cooling elements. Finger mean arterial pressure (MAP) was measured and cutaneous vascular conductance calculated as LDF/MAP. RESULTS: Histamine vasodilation was reduced in cold skin. Cetirizine shifted the histamine dose-response at both temperatures: statistically significantly at 14 degrees C only. Combined H1- and H2-receptor antagonism shifted the response significantly at both temperatures. CONCLUSIONS: H1- and H2-receptors mediate histamine-induced skin vasodilation. The sensitivity of these receptors, particularly the H1- receptor, is attenuated at low skin temperature. Whether the reduced effect in cold skin represents specific receptor or postreceptor desensitization, or nonspecific attenuation of cutaneous vasodilation remains to be elucidated.  (+info)

Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats. (6/872)

Lafutidine is a new type antiulcer agent with antisecretory and gastroprotective activities. We investigated the effect of lafutidine on indomethacin-induced antral ulcer in refed rats. Subcutaneous indomethacin injection resulted in the formation of gastric antral ulcer. Lafutidine (1-10 mg/kg, p.o.) reduced the area of ulcer in a dose-dependent manner when administered immediately after the indomethacin injection. Capsaicin at 3 mg/kg, p.o. and 16,16-dimethyl prostaglandin E2 at 3 microg/kg, p.o. also reduced the ulcer area. Chemical deafferentation of capsaicin-sensitive neurons or N(G)-nitro-L-arginine treatment aggravated the ulcer formation and abolished the preventive effect of lafutidine and capsaicin. After the induction of gastric ulcer, lafutidine given twice daily for 2.5 days reduced the area of ulcer in a dose-dependent manner with a significant effect at 10 mg/kg, p.o., as compared with that of the control group. In chemically-deafferentated rats, lafutidine did not show any healing effect. Cimetidine (30 mg/kg, p.o.) and famotidine (1 mg/kg, p.o.) had no significant effect on indomethacin-induced antral ulcer. These results may suggest that lafutidine, unlike cimetidine and famotidine, can prevent the indomethacin-induced antral ulcer formation and accelerate the healing of the ulcer in refed rats through mechanisms involving the capsaicin-sensitive afferent neurons and nitric oxide.  (+info)

Use of cimetidine, omeprazole, and ranitidine in pregnant women and pregnancy outcomes. (7/872)

Evidence documenting the safety of acid-suppressing drugs in pregnancy is very limited. The authors assessed the prevalence of congenital malformations in first trimester-exposed pregnancies to cimetidine, omeprazole, and ranitidine and compared it with nonexposed pregnancies between 1991 and 1996. Two different sources were used, the United Kingdom General Practice Research Database and the Italian Friuli-Venezia Giulia Health Database. The final study cohort included 1,179 pregnancies from the United Kingdom and 1,057 from Italy. Abortions or ectopic pregnancies were not included. There were 20 stillbirths and 2,261 live-born babies in both cohorts combined, with 100 offspring identified with a malformation. The overall malformation rate was 4.4%. The relative risks for nongenetic congenital malformations associated with the use of cimetidine, omeprazole, and ranitidine were 1.2 (95% confidence interval (CI): 0.6, 2.3), 0.9 (95% CI: 0.3, 2.2), and 1.4 (95% CI: 0.8, 2.4), respectively, compared with the nonexposed. No specific grouping in the distribution of malformations was observed in any of the three exposed groups. Moreover, no relation was found between drug exposure and preterm delivery or growth retardation. These findings suggest that the use of acid-suppressing drugs during the first trimester of pregnancy is not associated with a major teratogenic risk.  (+info)

Does cimetidine improve prospects for cancer patients?. A reappraisal of the evidence to date. (8/872)

BACKGROUND: Evidence first appeared in 1988 that cimetidine as an adjuvant may improve the survival of severely ill gastro-intestinal cancer patients when given peri- or postoperatively. Since then, several studies have appeared which suggest an anticancer activity for cimetidine, although few attempts have been made to corroborate their findings in large, placebo-controlled, double-blind studies. METHOD: We reviewed the literature concerning cimetidine's potential anticancer activity, particularly with regard to gastro-intestinal cancers. RESULTS: Most studies suggest that cimetidine may improve the outcome in cancer patients by a three-pronged mechanism involving (1) inhibition of cancer cell proliferation; (2) stimulation of the lymphocyte activity by inhibition of T cell suppressor function, and (3) inhibition of histamine's activity as a growth factor in tumours. CONCLUSION: Bearing in mind the experimental evidence, as well as the potential and excellent safety profile of cimetidine, more studies are required and justified to clarify cimetidine's protherapeutic activity.  (+info)

TY - JOUR. T1 - Cimetidine Does Not Inhibit Indomethacin-Induced Small Bowel Ulceration in the Rat. AU - Kauffman, Gordon L.. AU - Foley, Kevin. AU - Grossman, Morton I.. PY - 1979/1/1. Y1 - 1979/1/1. N2 - In earlier studies, cimetidine was found to protect against acetylsalicylic acid-induced gastric mucosal lesions by a mechanism other than inhibition of gastric acid secretion. The present study examined the possibility that cimetidine might protect against the intestinal mucosal injury produced by indomethacin. Small intestinal ulceration produced by oral indomethacin (20 mg kg-1) was studied in rats treated with 0.15 M NaCl (control); 80 mg kg-1 cimetidine; 400 mg kg -1 cimetidine; and 100 μug kg-1 16-16 dimethyl prostaglandin E2. The treatments were given 30 min before and 8 hr after indomethacin. Confirming previous studies, 16-16 DMPGE2 significantly (P , 0.01) reduced the number of lesions and the sum of the lengths of ulcers per rat when compared to the control group. Neither dose of ...
Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. It is available over-the-counter and is mainly used in the treatment of heartburn and peptic ulcers. The development of longer-acting H2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidine, decreased the use of cimetidine, and though it is still used, cimetidine is no longer among the more widely used of the H2-receptor antagonists.[citation needed] Cimetidine was discovered in 1971 and came into commercial use in 1977. Cimetidine was approved in the United Kingdom in 1976, and was approved in the United States by the Food and Drug Administration for prescriptions in 1979.[citation needed] Cimetidine is used to inhibit stomach acid production and is used in the treatment of heartburn and peptic ulcers. Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous ...
Elephant specific information, if available, is in blue.. Chemistry - An H2- receptor antagonist, cimetidine occurs as a white to off-white, crystalline powder. It has what is described as an unpleasant odor and a pKa of 6.8. Cimetidine is sparingly soluble in water and soluble in alcohol. Cimetidine HCl occurs as white, crystalline powder and is very soluble in water and soluble in alcohol. It has a pKa of 7.11 and the commercial injection has a pH of 3.8-6.. Storage/Stability/Compatibility - Cimetidine products should be stored protected from light and kept at room temperature. Do not refrigerate the injectable product as precipitation may occur. Oral dosage forms should be stored in tight containers.. The cimetidine injectable product is compatible with the commonly used IV infusions solu-tions, including amino acid (TPN) solutions, but should be used within 48 hours of dilution. Cimetidine is also reported to be compatible with the following drugs: acetazolamide sodium, amikacin sulfate, ...
Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was observed in 73% of patients after four weeks treatment and in 91% after eight weeks treatment. Symptoms were completely relieved in 60% of patients, improved in 34%, unchanged in 4%, and worsened in 2%. After healing patients returned to maintenance treatment with cimetidine 1.6-3.2 g daily, depending on the severity of their illness before treatment with omeprazole. By six months and 12 months only 55% and 33% of patients respectively were still in remission. This study suggests that when erosive oesophagitis is refractory to treatment with high dose cimetidine or ranitidine, treatment with omeprazole 40 mg daily for up to eight weeks is effective in inducing healing and relieving ...
The effect of two doses of cimetidine, 400 mg at night and 400 mg bd, on the protection of indomethacin (50 mg tid) induced mucosal damage was evaluated in a double blind study in patients with acute musculoskeletal disorders. Endoscopic mucosal lesions were scored before and after five to seven days of treatment. One hundred and ninety one patients were endoscoped before the trial, 34 (17.8%) had greater than one erosion and were not recruited. Forty patients were excluded for non-compliance, or lost to follow up. At the second endoscopy, oesophageal, and fundic damage was negligible. Gastric and duodenal lesion score in patients treated with cimetidine 400 mg bd: 2.7 (0.5) (SE); n = 42) was significantly lower (p less than 0.0122) than in placebo treated patients: 6.1 (0.9) (n = 50) or in patients treated with cimetidine 400 mg at night 7.1 (0.8) (n = 21). Cimetidine 400 mg bd provided significant protection for the duodenum, but its protection of antral mucosa did not reach statistical ...
An Unexpected Anti-Cancer Agent. The first studies to hint at cimetidines effectiveness against cancer were published in the late 1970s. Although scientists initially thought that cimetidine worked by enhancing immune function, later studies showed that cimetidine functions via several different pathways to inhibit tumor cell proliferation and metastasis. In a prospective, randomized, placebo-controlled study in 1988, 181 patients with gastric cancer received cimetidine (400 mg, twice daily) or placebo for two years or until death. Those given cimetidine had a significantly prolonged survival rate compared to the placebo group, particularly patients with more serious disease.1. In a 1994 study, just seven days of cimetidine treatment (400 mg twice daily for five days preoperative and intravenously for two days post-operative) in colorectal cancer patients decreased their three-year mortality rate from 41% to 7%. In addition, tumors in the cimetidine-treated patients had a notably higher rate of ...
The efficacy of Cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. Endoscopy showed that 14 of 21 patients treated with Cimetidine, compared with 5 of 18 patients treated with placebo, had normal or improved gastroduodenal mucosa (p , 0.05). Endoscopic signs of bleeding cleared or did not develop in 20 patients treated with Cimetidine and in 11 patients treated with placebo (p , 0.01). Significantly fewer blood transfusions were given to patients with endoscopic signs of bleeding in the cimetidine-treated group (0.5 ±0.3 [SE] units) than in placebo-treated patients (4.5 ±1.5 units; p , 0.05). The mortality rate was not statistically different between treatment groups. By preventing established gastroduodenal stress lesions from progressing in ...
Cimetidine is a powerful H2 receptor antagonist originally designed to treat ulcers by blocking the acid producing cells in the stomach. In the study three groups of rabbits were simultaneously induced with experimental periodontitis using P. gingivalis and treated with varying levels of topically applied cimetidine three times a week over a six-week period. Results showed that topical application of cimetidine at all concentrations inhibited inflammation and bone loss by approximately 90 ...
Seven in the chlorzoxazone group and 11 in the cimetidine group were lost to follow up. Concurrent use powder with Peptol tab 400mg may automatically result in increased and prolonged blood concentrations of cimetidine. As some imipramine packaging procedures must mind be strictly observed, the sandoz is the most suitable for company
Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms ...
Clinical studies have indicated that suppression of nocturnal acid is the most important factor in duodenal ulcer healing (see CLINICAL PHARMACOLOGY: Antisecretory Activity: Acid Secretion). This is supported by recent clinical trials (see CLINICAL TRIALS: Duodenal Ulcer: Active Duodenal Ulcer). Therefore, there is no apparent rationale, except for familiarity with use, for treating with anything other than a once-daily at bedtime dosage regimen. In a U.S. dose-ranging study of 400 mg at bedtime, 800 mg at bedtime and 1600 mg at bedtime, a continuous dose-response relationship for ulcer healing was demonstrated.. However, 800 mg at bedtime is the dose of choice for most patients, as it provides a high healing rate (the difference between 800 mg at bedtime and 1,600 mg at bedtime being small), maximal pain relief, a decreased potential for drug interactions (see PRECAUTIONS: Drug Interactions) and maximal patient convenience. Patients unhealed at 4 weeks, or those with persistent symptoms, have ...
Clinical studies have indicated that suppression of nocturnal acid is the most important factor in duodenal ulcer healing (see CLINICAL PHARMACOLOGY, Antisecretory Activity, Acid Secretion). This is supported by recent clinical trials (see CLINICAL PHARMACOLOGY, Clinical Trials, Active Duodenal Ulcer). Therefore, there is no apparent rationale, except for familiarity with use, for treating with anything other than a once-daily at bedtime dosage regimen.. In a U.S. oral dose-ranging study of 400 mg at bedtime, 800 mg at bedtime and 1600 mg at bedtime, a continuous dose response relationship for ulcer healing was demonstrated.. However, 800 mg at bedtime is the dose of choice for most patients, as it provides a high healing rate (the difference between 800 mg at bedtime and 1600 mg at bedtime being small), maximal pain relief, a decreased potential for drug interactions (see PRECAUTIONS, Drug Interactions) and maximal patient convenience. Patients unhealed at four weeks, or those with persistent ...
Dyspepsia, a poorly defined syndrome of episodic or recurrent upper abdominal discomfort after eating, has an estimated prevalence of 20% to 30% in the general population. The pathophysiology of this disorder is unknown. Postulated mechanisms include gastric acid hypersecretion, gastric motility disorder, Helicobacter pylori infection, and psychogenic stress. The investigation of dyspepsia is limited to patients with systemic signs or symptoms that suggest anatomic disease; otherwise, the treatment of dyspepsia is empiric. Results of previous randomized trials have generally failed to show any advantage of antacids or cimetidine over placebo (1), although a more recent trial found a benefit of cimetidine for relief of pain (2). Johannessen and colleagues compared on-demand cimetidine with placebo in treating the symptoms of dyspepsia. Their n-of-1 design addresses a limitation of previous studies: A subgroup of responders may have been lost in the random error associated with a majority of ...
Detailed Description:. Additional Study Purpose Details: Evaluate the effects of multiple doses of cimetidine on the pharmacokinetics (e.g., elimination from the body) of a single dose of PD 0332334.. On February 18th 2009, a decision to terminate further development for PD 0332334 was communicated to investigators in this study. The decision to terminate this study was not based on any safety concerns. ...
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Effect of cimetidine on cumulative survival rates in the colorectal cancer patients. The tumour tissues from individual patients obtained during curative operat
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Cimetidine information about active ingredients, pharmaceutical forms and doses by Sicor Pharmaceuticals, Cimetidine indications, usages and related health products lists
Cimetidine information about active ingredients, pharmaceutical forms and doses by Hi Tech Pharmaceuticals, Cimetidine indications, usages and related health products lists
Cimetidine is an H2-receptor antagonist that inhibits gastric acid secretion. In pregnancy, the antihistamine is primarily used for the treatment of peptic ulcer disease and for the prevention of gastric acid aspiration (Mendelsons syndrome) prior to delivery.. In studies with multiple animal species, no evidence of impaired fertility or teratogenesis was observed with doses up to 40 times higher than the usual human dose (1). Cimetidine does have weak antiandrogenic effects in animals, as evidenced by a reduction in the size of testes, prostatic glands, and seminal vesicles (2,3), and in humans, by reports of decreased libido and impotence (4). Conflicting reports on the antiandrogenic activity in animals exposed in utero to cimetidine have been published (5,6,7,8 and 9).. Three references, all from the same research group, described the effects on male rats of exposure to cimetidine from gestation up to the time of weaning (5,6 and 7). The rats had decreased weights of testicles, prostate ...
I just got a call back from Eltons vet. He said he consulted with his neurologist and they both agree that cimetidine will not do what prilosec will in reducing the CSF fluid. He said to start on that and then try Lyrica (which he said is expensive, which I know). He then mentioned steroids. I found this on Rods website http://www.cavalierhealth.org/syringomyelia.htm (I hope you dont mind the quote. Neurologists have been prescribing cimetidine (Tagamet, Zitac), which is a histamine
Define Tagamet HB. Tagamet HB synonyms, Tagamet HB pronunciation, Tagamet HB translation, English dictionary definition of Tagamet HB. n. A histamine receptor antagonist, C10H16N6S, that inhibits acid secretion in the stomach and is used to treat duodenal and gastric ulcers and...
Somberg L, Morris Jr., Fantus R, et al. Intermittent intravenous pantoprazole and continuous cimetidine infusion: effect on gastric pH control in critically ill patients at risk of developing stress-related mucosal disease. J Trauma 2008; 64(5):1202-10. Marrone GC, Silen W. Pathogenesis, diagnosis and treatment of acute gastric mucosal lesions. Clin Gastroenterol 1984; 13(2):635-50. Hastings PR, Skillman JJ, Bushnell LS, Silen W. Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled, randomized trial in 100 critically ill patients. N Engl J Med 1978; 298(19):1041-5. Martin LF, Booth FV, Karlstadt RG, et al. Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Crit Care Med 1993; 21(1):19-30. Conrad SA, Gabrielli A, Margolis B, et al. Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal ...
Title: MedicineNet cimetidine Specialty, Description: MedicineNet cimetidine Specialty, By: Feedage Forager, ID: 331221, Grade: 93, Type: RSS20
Robert Hodgkinson, Raymond Glassenberg, Thomas H. Joyce, Dennis W. Coombs, Gerard W. Ostheimer, Charles P. Gibbs; Comparison of Cimetidine (Tagamet®) with Antacid for Safety and Effectiveness in Reducing Gastric Acidity before Elective Cesarean Section. Anesthesiology 1983;59(2):86-90. doi: https://doi.org/.. Download citation file:. ...
TAGAMET HB SUSPENSION (Cimetidine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Every so often you might find that your feline friend is prescribed a drug that you might also use, and for exactly the same condition. Cimetidine, the generic name for the Tagamet brand, is one of ...
Effect of lafutidine (30 mg/kg) and cimetidine (10 mg/kg), relative to vehicle, on (A) intragastric acidity and (B) weight of gastric content measured 60 and 12
Health Products / Supplements China, Cimetidine Tablets 400mg, Indications: Treatment and maintenance therapy of active duodenal ulcer. Treatment of benign gastric ulcers . Treatment ...
Cimetidine is a histamine H2-receptor antagonist for treatment of ulcus duodeni and ulcus ventriculi. Normally, this active is wet-granulated to...
Cimetidine has been studied as an additive in cancer chemotherapy. It is claimed to reduce the side effects of Cisplatin. This study focuses on possible interactions between Cisplatin and cimetidine on the molecular level. Due to the fact that cimetidine is metabolized in the liver, interactions between its metabolites and Cisplatin are also investigated. By means of LC/ESI-MS, Cisplatin-cimetidin ...
It is widely accepted that angiotensin II, ACTH and potassium are the major factors controlling the release of aldosterone. Conflicting results have been reported about the role of serotonin,...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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Histamine stimulation of adenylate cyclase activity in broken cells isolated from guinea pig gastric mucosa was competitively inhibited by the thiazole derivative ICI 125,211 and the furane derivative ranitidine, with pA2 of 7.62 (Ki = 2.39 x 10-8 M) and pA2 of 6.90 (Ki = 1.25 x 10-7 M), respectively, i.e., potencies 19 times and 4 times superior to that of the classical H2-receptor antagonist cimetidine (pA2 = 6.34; Ki = 4.57 x 10-7 M). These results are consistent with the reported pharmacological potencies of the antagonists on guinea pig right atrium and on gastric acid secretion in vivo. Thus, the requirement of an imidazole ring in the structure of H2-receptor antagonists can be definitely ruled out.. ...
Analysis of ambulatory 24-hour intragastric pH monitoring. Comparison of the effects of cimetidine 200mg QID and 800mg UID.:Comparison of the effects of cimetidine 200mg QID and 800mg UID (1988 ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The algorithm (sp) on C. Rusbridges website refers to those two drugs so I Googled to see what they are used for and found they are for stomach acid. What is the connection with SM and neurological pain?
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Tell your doctor or health care professional if your pain does not start to get better or gets worse. You may need to take this medicine for several days before your symptoms get better. Finish the full course of tablets prescribed by your doctor or health care professional even if you feel better.. Do not take with aspirin, ibuprofen, or other antiinflammatory medicines unless directed to do so by your health care professional. These can make your condition worse.. Do not smoke cigarettes or drink alcohol. These increase irritation in your stomach and can increase the time it will take for your ulcer to heal.. If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor or health care professional right away. You may have a bleeding ulcer.. ...
Revision date indicates the date the MSDS or SDS was last revised. MSDS / SDS are dated when they are originally issued AND when any significant change has been made to the chemical compound or research has revealed a health or physical hazard different from what was originally stated. Additional information regarding MSDS / SDS is available at https://www.osha.gov ...
This medication is typically used 4 times a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Your doctor has prescribed this medication for a specific period of time. Take it for the entire time prescribed in order to achieve the medications full benefit, even if you begin to feel better sooner. Avoid using or consuming substances that may irritate your stomach, such as: ...
The drug brand named Ulcenon contains generic salt - Cimetidine and is manufactured by EMS Industria Farmaceutica.Ulcenon is mainly associated with symptoms and indications - The International Classification of Diseases (ICD) - A02BA01 - Cimetidine ...
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To the editor: Increasingly frequent reports have attributed neurologic complications other than encephalopathy to cimetidine toxicity. I wish to report a case of chorea apparently caused by cimetidine.. A 72-year-old woman was admitted to the Neurological Institute of New York after several weeks of abnormal movements. The history showed chronic obstructive pulmonic disease treated with theophylline, 800 mg daily, and terbutaline, 15 mg daily in divided doses. Haloperidol had been prescribed for an affective disorder, but symptoms had resolved and therapy had been terminated 18 months earlier. Barium swallow had shown a duodenal ulcer 11 months previously; therapy included cimetidine, ...
Cimetidine (200mg) - 10 Tablet (Cimetidine) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Zydus Cadila Healthcare Ltd.
TY - JOUR. T1 - Cimetidine, ranitidine, and pirenzepine in the treatment of duodenal ulcer. T2 - A six-month low-dose treatment period followed by a six-month observation period. AU - Leandro, G.. AU - Battaglia, G.. AU - Di Mario, F.. AU - Cozzolongo, R.. AU - Giannuzzi, V.. AU - Cannizzaro, R.. AU - Manghisi, O. G.. AU - Naccarato, R.. PY - 1990. Y1 - 1990. N2 - One hundred twenty-one consecutive patients with healed duodenal ulcer (DU) entered a single-blind, randomized, one-year study. They were treated with either cimetidine 400 mg (41 patients), ranitidine 150 mg (40 patients), or pirenzepine 50 mg (41 patients) at bedtime for the first six months and had no treatment in the subsequent six-month observation period. The patients were well matched in common clinical and biochemical parameters. An upper gastrointestinal endoscopy was performed every three months in all asymptomatic subjects and at every symptomatic relapse. Statistics were calculated by chi-square test with Yates correction, ...
To further breakdown all this pre-dose potentiation, Ill make it easy for you guys and just tell ya how many pills to take, and the exact way I consume them * T-45) 3 200mg Cimetidine pills, washed down with a HUGE tonic waterwhite grapefruit juice cocktail. * T-35) 1 Coriciden Cough & Cold Low Blood.. Jul 30, 2000. Using Antihistamines, Anticholinergics, and Depressants To Potentiate Opiates, And Dealing With Opiate Side Effects. Antihistamine Aficionado. A dose of Tagamet an hour before a hydrocodone/oxycodone session will make the drug last longer and have a better effect. Antacids should be taken at least.. Cimetidine: The concomitant use of cimetidine can potentiate morphine effects and increase risk of hypotension, respiratory depression, profound sedation, coma, and death. Diuretics: Opioids can reduce the efficacy of diuretics by.. There seems to be a split on whether Cimetidine is a useful when taken prior to kratom ingestion. I humbly submit ROA, with regards to brewing tea.. These ...
Secretion of acid by the stomach depends on the binding of gastric acetylcholine and histamine to their respective receptor on the parietal cell surface. Blocking either of these leads to a reduction in acid secretion. H1 receptors are located on blood vessels, smooth muscle and in the skin. H2 receptor are located in the stomach and stimulation results in gastric acid secretion. Drugs which block H2 receptors were developed in several stages. The first member of this group to be made commercially available was cimetidine which was released in the UK in November 1976. Since then, it and the other available H2 receptor antagonist ranitidine, which was marketed in 1981, have become widely used. (2). Cimetidine. Cimetidine is used in the short-term treatment of active, benign, gastric ulcer. In studies in patients with gastric ulcers receiving supplemental antacid cimetidine promoted healing of ulcers in up to 70% of patients after 4 weeks and in 66-100% of patients after 6 weeks. In controlled ...
Available evidence indicates that there are two types of Na(+)-H+ exchangers, type A (housekeeping type) and type B (epithelial or apical type), in mammalian cells. We have recently reported, using isolated membrane vesicles, that these two types can be differentiated by their relative sensitivities to inhibition by clonidine and cimetidine [Kulanthaivel, Leibach, Mahesh, Cragoe & Ganapathy (1990) J. Biol. Chem. 264, 1249-1252]. The present study was undertaken to determine whether this approach is also effective in cultured cells. The JAR human placental choriocarcinoma cell line and the opossum kidney (OK) cell line, when grown as confluent monolayer cultures on an impermeable plastic support, express Na(+)-H+ exchanger activity which is measurable by determining Na+ uptake into the cells from the culture medium. The JAR cell Na(+)-H+ exchanger was found to be about 100 times more sensitive to inhibition by dimethylamiloride than the OK cell Na(+)-H+ exchanger. Inhibition studies with ...
2 Answers - Posted in: norco, ultram, unisom, cimetidine, clonazepam - Answer: Hi miallison89 & welcome to the site. Please read the interreactions ...
1. Salom IL, Silvis SE, Doscherholmen A. Effect of cimetidine on the absorption of vitamin B 12. Scand J Gastroenterol 17: 129 - 131, 1982. 2. Streeter AM, Goulston KJ, Bathur FA, et al. Cimetidine and malabsorption of cobalamin. Dig Dis Sci 27: 13 - 16, 1982. 3. Blache J, Zittoun J, Marquet J, et al. Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B 12. Gastroenterol Clin Biol 7: 381 - 384, 1983. 4. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H 2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 112: 458 - 463, 1988. 5. DArcy PF and McElnay JC. Drug interactions in the gut involving metal ions. Rev DrugMetabol Drug Interact 5(2 - 3):83 - 112, 1985. 6. Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc 44(1): 124, 1985. 7. Sturniolo GC, et al. Inhibition of gastric acid secretion reduces zinc absorption in man. JAm Coll Nutr 4: 372 - 375, 1991. 8. Aymard JP, Aymard B, Netter P, et ...
1. CIMETIDINE - Concurrent administration of venlafaxine and cimetidine (both at steady state) has resulted in a 43% reduction in the oral clearance of venlafaxine and a 60% increase in the AUC and peak concentration of venlafaxine (Prod Info Effexor(R), 2000). The major metabolite, O-desmethylvenlafaxine, was unaffected by cimetidine, and is present in much greater amounts than the parent drug. It is not known if a clinically significant interaction will occur with this combination. Patients should be monitored for signs of venlafaxine toxicity, and the dose of venlafaxine reduced if necessary ...
The present study examined the effect of histamine H2-receptor antagonists and exogenous histamine on growth of malignant melanoma implant in mice. Drugs were administered to B16BL6 malignant-melanoma-implanted syngeneic mice, and the tumor volume was measured throughout the experiments. Cell proliferation was assessed by MTT assay and mRNA expression was determined by RT-PCR. Both roxatidine and cimetidine significantly suppressed growth of B16BL6 implant compared with vehicle. On the other hand, systemically administered histamine significantly stimulated growth of B16BL6 implants. In addition, the histamine-stimulated B16BL6 implant growth was markedly suppressed by co-administration of cimetidine in a dose-dependent manner. H2-receptor antagonists, however, failed to affect in vitro proliferation of B16BL6 cells. H2-receptor mRNA was detected in B16BL6 implants but not in the cell line. These results indicated that both endogenous and exogenous histamine have ability to stimulate growth of malignant
The literature on H2- antagonist drug interactions is now extensive. The whole subject is so complicated as to make things difficult for the potential prescriber. However, it is possible to reduce...
Retrograde colonization of the oropharynx from the stomach by microaspiration of gastric fluid is a recently recognized phenomenon associated with increased gastric pH that may result in pneumonia during ventilation therapy. In a prospective study we
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Antidepressants can increase suicidal thoughts and actions in some children and adolescents younger than 18 years of age. They are thought to work by their action on brain chemicals called amines which are involved in controlling mood. However, vaccine-associated cases of polio do occur. Treatment varies based on the type of parasite, but typically involves eliminating the parasite from the pet and making sure that the home is also clear of adult parasites and eggs. There are also show you look and feel. However, if these symptoms are severe and/or accompanied by fever or significant exhaustion, they likely indicate the flu, which is a distinct type of viral respiratory infection caused by an influenza virus (CDC 2011; Hayden 2011; NIAID 2011a). SmithKline Beecham was dealt a second setback yesterday in its regulatory quest to turn its prescription ulcer drug Tagamet into an over-the-counter treatment for heartburn.. In this article, I will reveal what has worked for me personally to ward off ...
If you have mild reflux symptoms that occur less than two times a week, you can start with a low dose of famotidine (Pepcid) or cimetidine (Tagamet). Ranitidine (Zantac), another H2 blocker, was recently removed from the market because it was found to contain higher-than-acceptable levels of cancer-causing substances.. ...
104 duodenal ulcer patients were classified into non-smokers (76) and smokers (28). Their age range was between 14-72 years. They were randomly treated with cimetidine (28 non-smokers and 8 smokers), colloidal bismuth (27 non-smokers and 10 smokers)
Many medicines interact with alcohol. This includes both prescription medicines and ones you buy over the counter. For example, if you drink while you take a diabetes medicine such as insulin or sulfonylureas, such as glipizide and glyburide, it could cause very low blood sugar levels. If you drink while you take medicine for heartburn, such as cimetidine (Tagamet) or ranitidine (Zantac), it could cause a fast heartbeat. Common medicines that interact with alcohol include:. ...
Many medicines interact with alcohol. This includes both prescription medicines and ones you buy over the counter. For example, if you drink while you take a diabetes medicine such as insulin or sulfonylureas, such as glipizide and glyburide, it could cause very low blood sugar levels. If you drink while you take medicine for heartburn, such as cimetidine (Tagamet) or ranitidine (Zantac), it could cause a fast heartbeat. Common medicines that interact with alcohol include:. ...
Tagamet (Cimetidine) or Prilosec (Omeprazole)? No Yes Diltiazem (Cardizem) or Verapamil (Calan, Isoptin)? No Yes Fluconazole (Diflucan) or Itraconazole (Sporonox)? No Yes Do you eat grapefruit or drink grapefruit juice? Have you ever taken any prescription drugs (such as fen-phen) for weight loss? Have you ever been treated with a bisphosphonate drug (Fosamax, Aredia, Zometa, Actonel, Boniva)? If so, when No Yes did the treatment begin? When did the treatment end ...
Special Instructions:Abnormal kidney function or use of diuretics may influence test results. This test should not be performed on individuals with kidney disorders. In addition, certain medicines may impact test results [e.g. cephalosporins (e.g. Cefoxitin), cimetidine (Tagamet), fibrates (e.g. Ciprofibrate) and trimethoprim-sulfamethoxazole (Bactrim)]. Let your physician know about your use of these medications. Do not change use of medications unless instructed to do so by your healthcare provider. Avoid eating (whole and ground) flax seeds and sesame seeds for at least 48 hours before beginning urine collection. If you are experiencing a urinary tract infection, delay collection of specimen until after completing treatment ...
Special Instructions:Abnormal kidney function or use of diuretics may influence test results. This test should not be performed on individuals with kidney disorders. In addition, certain medicines may impact test results [e.g. cephalosporins (e.g. Cefoxitin), cimetidine (Tagamet), fibrates (e.g. Ciprofibrate) and trimethoprim-sulfamethoxazole (Bactrim)]. Let your physician know about your use of these medications. Do not change use of medications unless instructed to do so by your healthcare provider. Avoid eating (whole and ground) flax seeds and sesame seeds for at least 48 hours before beginning urine collection. If you are experiencing a urinary tract infection, delay collection of specimen until after completing treatment ...
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Glaxo farthest the model Rubrics for research papers in middle school by replacing the imidazole surpass of cimetidine with a furan wedge with a synthesis -befriending substituent, and in doing so developed ranitidine.
4 Answers - Posted in: anxiety, insomnia, generalized anxiety disorder - Answer: I took it for about 6 months towards the latter taking 15mgs at...
Prostacyclin (PGI2) induced a dose-dependent decrease in blood pressure with slight increases in heart rate and body temperature, when administered at the doses of 0.1-100 ~g into the lateral cerebral ventricle (i.c.v.) of the urethane-anaesthetised rat. When the same doses were administered intravenously, both the blood pressure and heart rate decreased. Central pretreatment wib~ sodiurn meclofenamate (1 mg/rat i.c.v.) antagonised the central hypotensive effect of PGI2 but i.c.v. pretreatrnent of the rats with indomethacin (1 mg/rat) failed to affect the PGI 2-induced hypotension. Central pretreatment with two histamine H2-receptor antagonists, cimetidine (500 ~g/rat i.c.v.) or metiamide (488 ~g/rat i.c.v.), antagonised the blood pressure lowering effect of 0.1 ~g dose of PGI2 but failed to affect the hypotension induced by higher PGI2 doses. Therefore the main central hypotensive effect of PGI2 seems not to be associated with the stimulation of histamine H2 -receptors in the brain. The ...
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Zitac is cheaper at VetUK. Zitac Tablets for Dogs is for the symptomatic treatment for the reduction of vomiting associated with chronic gastritis in dogs. Zitac Vet 100 mg tablets are oblong tablets, scored on both sides, containing cimetidine 100...
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Diflucan official prescribing information for healthcare professionals. In premature newborns (gestational age 26 to 29 weeks), the mean (cv) clearance However, the administration of cimetidine 600 mg to 900 mg intravenously over a . In the study, subjects ingested placebo or 400 mg fluconazole on Day 1 followed
A lengthy list of drugs can cause problems when combined with Effexor XR. This eMedTV resource covers cimetidine, fentanyl, haloperidol, indinavir, ketoconazole, and other medications, describing the problems that might occur.
Altered que consecuencias trae el consumo de viagra anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are coadministered with warfarin. They may also be more likely to lose too much salt (hyponatremia), especially if they are also taking water pills (diuretics) with this medication. The risk differences (drug vs. Placebo), however, were relatively stable within age strata and across indications. Cimetidine Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. The physician who elects to use Lexapro for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. Consequently, it is not possible to provide a meaningful estimate of the proportion ...
The biology of CYPs is complex. It reveals its secrets only in a committed relationship, and the multiplicity of CYP isoforms and their myriad products elude a casual grasp. However, this complexity belies the widespread physiological, pathological, and toxicological significance of these enzymes. The CYPs catalyze the controlled addition of molecular oxygen to carbon-carbon bonds, which is one of the most elegant reactions devised by nature and is used by all organisms to remove and detoxify foreign chemicals. It is, however, a Faustian bargain. The reaction proceeds via the formation of an alkoxyl radical-like intermediate and leaks superoxide and hydrogen peroxide,7 both of which could be highly toxic. Consequently, CYP-based detoxification of alcohols, drugs, and chemicals often results in increased radical generation and causes oxidative stress.7 The protective effects of CYP inhibitors (chloramphenicol, cimetidine, and sulfaphenazole) against myocardial ischemic injury have been linked to ...
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I have steadily been reducing carbs since the beginning of the year. Over the past month I have kept them to to about 25g daily (40g including fiber).
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Cimetidine, diltiazem, verapamil. May increase concentration of lofepramine in the blood plasma. Hydralazine. Enhanced ...
Cimetidine was the first of a new class of drugs, the H2-receptor antagonists. In 1980, Black's association with the University ... He was greatly involved in the synthesis of cimetidine, at the time a revolutionary drug for the treatment and prevention of ... He was awarded the Nobel Prize for Medicine in 1988 for work leading to the development of propranolol and cimetidine. Black ... Black was also responsible for the development of cimetidine, an H2 receptor antagonist, a drug used to treat stomach ulcers. ...
"anTAGonist" and "ciMETidine"". American Chemical Society. 2005. Retrieved 2005-12-25. CS1 maint: discouraged parameter (link) " ...
Comparison with cimetidine". Digestive Diseases and Sciences. 40 (11): 2469-72. doi:10.1007/bf02063257. PMID 7587834. S2CID ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Curry SH, DeVane CL, Wolfe MM (1985). "Cimetidine interaction with amitriptyline". Eur J Clin Pharmacol. 29 (4): 429-33. doi: ... Similar changes occur with a moderate inhibitor of CYP2C19 and other cytochromes cimetidine: amitriptyline level increases by ...
Cimetidine slows down the elimination rate of nitrazepam, leading to more prolonged effects and increased risk of accumulation ... Ochs HR, Greenblatt DJ, Gugler R, Müntefering G, Locniskar A, Abernethy DR (August 1983). "Cimetidine impairs nitrazepam ...
The discovery of burimamide ultimately led to the development of cimetidine (Tagamet). Metiamide Cimetidine Clayden, Jonathan; ...
Ruffalo RL, Thompson JF, Segal J (September 1981). "Cimetidine-benzodiazepine drug interaction". Am J Hosp Pharm. 38 (9): 1365- ... Prazepam may interact with cimetidine. Alcohol in combination with prazepam increases the adverse effects, particularly ...
showed that cimetidine was ineffective. Hayashi et al. applied topical calcipotriol to a patient with a successful result.[ ... Interferons can also be used effectively together with retinoids.[citation needed] Cimetidine was reported to be effective ...
Cimetidine works by slowing tumor growth; it is a histamine blocker that maintains the body's immune response which aids in the ... Cimetidine has not been proven to efficiently resolve tumors completely. A vaccine that is similar to the effective canine ...
The drug cimetidine heightens praziquantel bioavailability. The drug's mode of action is not exactly known at present, but ... Metwally A, Bennett JL, Botros S, Ebeid F (April 1995). "Effect of cimetidine, bicarbonate and glucose on the bioavailability ... "Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen ...
Cimetidine increases the effects of clobazam. Valproate. Overdose and intoxication with benzodiazepines, including clobazam, ...
Conversely, 800 mg of cimetidine 1 hr before the start and again at 50 miles of a 100-mile running race substantially decreased ... Ingestion of 800 mg of cimetidine two hours before running a marathon did not significantly affect the frequency of ... Moses FM, Baska RS, Peura DA, Deuster PA (October 1991). "Effect of cimetidine on marathon-associated gastrointestinal symptoms ... Baska RS, Moses FM, Deuster PA (August 1990). "Cimetidine reduces running-associated gastrointestinal bleeding. A prospective ...
Cimetidine may influence the absorption of doxepin. Alcohol may potentiate some of the CNS depressant effects of doxepin. ...
Guss DA (1998). "Scombroid fish poisoning: successful treatment with cimetidine". Undersea Hyperb Med. 25 (2): 123-5. PMID ...
Cimetidine increased Isradipine mean peak plasma levels. A downward dose adjustment may be necessary with this particular ...
There is no high-quality evidence for cimetidine. However, oral cimetidine has been used as an alternative treatment for the ... The oral medication cimetidine, or podophyllotoxin cream applied to the skin, may also be used for treatment. Approximately 122 ... Scheinfeld N (March 2003). "Cimetidine: a review of the recent developments and reports in cutaneous medicine". Dermatol. ...
... and 10 times the activity of cimetidine. Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer ... 1980). "Effect of cimetidine on gastric bacterial flora". Lancet. i (8170): 672-674. doi:10.1016/s0140-6736(80)92826-3. PMID ... Glaxo refined the model further, by replacing the imidazole ring of cimetidine with a furan ring with a nitrogen-containing ... Its development was a response to the first in class histamine H2 receptor antagonist, cimetidine, developed by Sir James Black ...
Cimetidine also affects the body's uptake of rimantadine. Taking anticholigenic drugs with amantadine may increase underlying ...
Cimetidine, rifampicin, and thioridazine cause interactions with zaleplon. Cimetidine and grapefruit are known to increase ... before one consumes cimetidine (or grapefruit) while also taking zaleplon. Zaleplon is a high-affinity ligand of positive ...
Such as occurs when cimetidine is taken with didanosine. In this case, a gap of two to four hours between taking the two drugs ...
Pounder R (1975). "24-Hour Control of Intragastric Acidity by Cimetidine in Duodenal-Ulcer Patients". The Lancet. 306 (7944): ... "Inhibition of food-stimulated gastric acid secretion by cimetidine". Gut. 17 (3): 161-8. doi:10.1136/gut.17.3.161. PMC 1411161 ...
... the effect of antacids or cimetidine". Digestive Diseases and Sciences. 27 (6): 485-490. doi:10.1007/BF01296725. ISSN 0163-2116 ...
Azlocillin, cimetidine and probenecid increase blood levels of difloxacin. Compounds (i.e. sucralfate, antacids, multivitamins ...
Somogyi A, Stockley C, Keal J, Rolan P, Bochner F (May 1987). "Reduction of metformin renal tubular secretion by cimetidine in ... The H2-receptor antagonist cimetidine causes an increase in the plasma concentration of metformin by reducing clearance of ... form of cimetidine, may compete for the same transport mechanism. A small double-blind, randomized study found the antibiotic ... metformin by the kidneys; both metformin and cimetidine are cleared from the body by tubular secretion, and both, particularly ...
The anti-ulcer drug cimetidine is generated using such reactivity. Related reactions exploit the bifunctionality of cyanamide ...
Finally, cimetidine S-oxygenation or ranitidine N-oxidation can also be used as a functional probe of human FMO3. With the ... 1993). "Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine". Drug Metab. Dispos. 21 (4): 587-97. PMID ... commonly used drugs including cimetidine, ranitidine, clozapine, methimazole, itopride, ketoconazole, tamoxifen and sulindac ...
Cimetidine: Cimetidine inhibits CYP450 enzymes involved in metabolism of CCBs. Blood concentration of calcium channel ...
Cimetidine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking cimetidine,. *tell your doctor and pharmacist if you are allergic to cimetidine or any other medications. ... Cimetidine comes as a tablet and a liquid to take by mouth. It is usually taken once a day at bedtime or two to four times a ... Over-the-counter cimetidine is usually taken once or twice a day with a glass of water. To prevent symptoms, it is taken within ...
Safety of cimetidine Br Med J (Clin Res Ed) 1985; 291 :1721 doi:10.1136/bmj.291.6510.1721-b ... Safety of cimetidine. Br Med J (Clin Res Ed) 1985; 291 doi: https://doi.org/10.1136/bmj.291.6510.1721-b (Published 14 December ...
Other names: Guanidine, N-cyano-N-methyl-N-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-; N-Cyano-N-methyl-N-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine; 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine; 2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine; Eureceptor; FPF 1002; Gastromet; SKF 92334; Tagamet; Tametin; Tratul; Ulcedine; Ulcimet; Ulcomet; Guanidine, N-cyano-N-methyl-N-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-; Acibilin; Acinil; Cimal; Cimetag; Cimetum; Dyspamet; Edalene; Peptol; Ulcedin; Ulcerfen; Ulcofalk; Ulcomedina; Ulhys ...
Cimetidine and duodenal ulcer. Br Med J 1979; 1 :955 doi:10.1136/bmj.1.6168.955 ... Cimetidine and duodenal ulcer.. Br Med J 1979; 1 doi: https://doi.org/10.1136/bmj.1.6168.955 (Published 07 April 1979) Cite ...
A list of US medications equivalent to Bio-Cimetidine is available on the Drugs.com website. ... Bio-Cimetidine is a medicine available in a number of countries worldwide. ... Bio-Cimetidine may be available in the countries listed below.. Ingredient matches for Bio-Cimetidine. Cimetidine. Cimetidine ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research ... Cimetidine, Serum or Plasma. 2. Clinitek 500 Urine Chemistry Analyzer. 3. Clinitek Atlas Automated Urine Chemistry Analyzer ( ...
Cimetidine Inhibition of Stimulated Gastric Acid Secretion Stimulant. Stimulant Dose. Cimetidine. % Inhibition. ... Cimetidine has a bitter taste and characteristic odor.. Cimetidine is soluble in alcohol, slightly soluble in water, very ... Cimetidine is rapidly absorbed after oral administration and peak levels occur in 45 to 90 minutes. The half-life of cimetidine ... Cimetidine is not an anticholinergic agent. Studies have shown that cimetidine inhibits both daytime and nocturnal basal ...
Cimetidine también se usa para el tratamiento de la enfermedad por reflujo gastroesofágico (GERD, por sus siglas en inglés), ... Cimetidine es una medicina para reducir el ácido estomacal que se usa para tratar y prevenir ciertos tipos de úlcera estomacal ... Qué es cimetidine?. Cimetidine es una medicina para reducir el ácido estomacal que se usa para tratar y prevenir ciertos tipos ... Cimetidine usualmente se toma con comidas o al acostarse.. Para prevenir la acidez de los alimentos o bebidas, tome cimetidine ...
Cimetidine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists ( ... Decreased cimetidine absorptionb. Administer 1 hour before or after cimetidine in the fasting state, or 1 hour after cimetidine ... Tagamet (cimetidine tablets, cimetidine hydrochloride liquid, and cimetidine hydrochloride injection) prescribing information. ... Tagamet (cimetidine tablets, cimetidine hydrochloride liquid, and cimetidine hydrochloride injection) prescribing information. ...
Find the most comprehensive real-world treatment information on Cimetidine at PatientsLikeMe. 9 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Cimetidine. ... 2 patient evaluations for Cimetidine Sort by: Most recent * ...
Cimetidine Inhibition of Stimulated Gastric Acid Secretion Stimulant. Stimulant Dose. Cimetidine. % Inhibition. ... Cimetidine (800 mg twice daily) Cimetidine (400 mg 4 times daily) Placebo. p-Value (800 mg twice daily vs. placebo) ... Cimetidine has a bitter taste and characteristic odor.. Cimetidine is soluble in alcohol, slightly soluble in water, very ... Cimetidine is rapidly absorbed after oral administration and peak levels occur in 45 to 90 minutes. The half-life of cimetidine ...
... cimetidine) oral on - WebMD including the side effects, drug interactions, effectiveness, ease of use and satisfaction. ...
Cimetidine (SKF-92334); This compound is a featured product for ADME Tox research; H,SUB,2,/SUB, histamine receptor antagonist ...
Cimetidine was not mutagenic to and did not cause DNA damage in Salmonella typhimurium or Escherichia coli. Cimetidine ... N-Nitrosocimetidine is rapidly converted to cimetidine in vivo in experimental animals. Cimetidine did not induce single-strand ... There is inadequate evidence for the carcinogenicity of cimetidine in experimental animals. Overall evaluation. Cimetidine is ... CIMETIDINE. (Group 3). For definition of Groups, see Preamble Evaluation. VOL.: 50 (1990) (p. 235) CAS No.: 51481-61-9. ...
Find user ratings and reviews for cimetidine oral on WebMD including side effects and drug interactions, medication ... told me to try over counter walmart-Equate cimetidine 200mg. $6.97, 60tabs ( = Tagamet HB 200 ) Have not had a prob. for 9 ... told me to try over counter walmart-Equate cimetidine 200mg. $6.97, 60tabs ( = Tagamet HB 200 ) Have not had a prob. for 9 ... Read user comments about the side effects, benefits, and effectiveness of cimetidine oral. ...
Besidin information about active ingredients, pharmaceutical forms and doses by Coup, Besidin indications, usages and related health products lists
Cimetidine indications, usages and related health products lists ... Available forms, composition and doses of Cimetidine:. *Tablets ... Cimetidine information about active ingredients, pharmaceutical forms and doses by Mylan, ... Oral; Cimetidine 200 mg*Tablets; Oral; Cimetidine 300 mg*Tablets; Oral; Cimetidine 400 mg*Tablets; Oral; Cimetidine 800 mg. ... Find online pharmacy, drugstore, pharma or beauty shop where to order or buy Cimetidine brand or generic online:. ...
MYLAN CIMETIDINE, 400MG, TABLET. Common uses. This medication reduces the production of stomach acid. Typically, it is used for ...
Cimetidine is used to treat stomach and duodenal ulcers, reflux of stomach acid into the esophagus, and Zollinger-Ellison ... Cimetidine is available as a prescription drug and as a... ... Cimetidine is a member of the H-2 blocker (histamine blocker) ... Cimetidine. Drug Information. Cimetidine is a member of the H-2 blocker (histamine blocker) family of drugs that prevents the ... In healthy volunteers, a magnesium hydroxide/aluminum hydroxide antacid, taken with cimetidine, decreased cimetidine absorption ...
... Apr 15, 2006, 18:39, Reviewed by: Dr. Shivani Arora. ... Cimetidine is a powerful H2 receptor antagonist originally designed to treat ulcers by blocking the acid producing cells in the ... "The findings of this study provide morphological and histological evidence that topically active cimetidine is a potent ... "The findings of this study provide morphological and histological evidence that topically active cimetidine is a potent ...
Cimetidine, an H-2 antihistamine stimulates prolactin secretion in man. J Clin Endocrinol Metab 1977;45:367-70.PubMedGoogle ... Ascorbic acid Cimetidine Cytochrome P-450 Hydrocortisone Metabolism Steroid hydroxylases This is a preview of subscription ... Cimetidine can bind to cytochrome P-450 covering the active haem group, the cytochrome proves to be of vital importance for ... Cimetidine alters plasma catecholamine levels and cortisol and aldosterone excretion. N Engl J Med 1982;306:1054-9.Google ...
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI). The safety and scientific validity of this study is the ... Cimetidine. Anti-Ulcer Agents. Gastrointestinal Agents. Histamine H2 Antagonists. Histamine Antagonists. Histamine Agents. ... Drug Information available for: Cimetidine Pramipexole dihydrochloride Pramipexole Genetic and Rare Diseases Information Center ... 300 mg Dexpramipexole Oral Dose (to be taken in conjunction with multiple doses of Cimetidine at 400 mg per dose) ...
Buy Cimetidine online for as low as $0.14 per tablet from Canadian and international pharmacies. ... Cimetidine Drug Information. * Cimetidine Overview. Cimetidine is used to treat ulcers of the stomach and intestines and ... Cimetidine Misdose. If you miss a dose of Cimetidine, take it as soon as you remember. If it is near the time of the next dose ... How to Use Cimetidine. Take Cimetidine by mouth with or without food as directed by your doctor. The dosage and length of ...
Cimetidine is used to reduce the pain of ulcer and heartburn or to assist in the healing of ulcers and damage caused by ... 02229717 PMS-CIMETIDINE 200MG TABLET. 02229718 PMS-CIMETIDINE 300MG TABLET. 02229719 PMS-CIMETIDINE 400MG TABLET. 02229720 PMS- ... The usual recommended adult dose of cimetidine ranges from 200 mg twice a day to 600 mg 4 times a day (usually with meals and ... Cimetidine is used to reduce the pain of ulcer and heartburn or to assist in the healing of ulcers and damage caused by ...
Cimetidine is used to reduce the pain of ulcer and heartburn or to assist in the healing of ulcers and damage caused by ... The usual recommended adult dose of cimetidine ranges from 200 mg twice a day to 600 mg 4 times a day (usually with meals and ... Cimetidine is used to reduce the pain of ulcer and heartburn or to assist in the healing of ulcers and damage caused by ... Cimetidine can be taken with or without food.. It is important to take this medication exactly as prescribed by your doctor. If ...
To the editor: In his review of the clinical uses of cimetidine (1), Freston concludes that although "evidence that cimetidine ... Cimetidine and Antacids DAVID H. FRANKEL, M.D.; MICHAEL O. BLACKSTONE, M.D. ... Cimetidine and Antacids. Ann Intern Med. 1983;98:412-413. doi: 10.7326/0003-4819-98-3-412_2 ... that the evidence supporting the combined use of antacids plus cimetidine to prevent rebleeding in peptic ulcer disease is also ...
Chorea and Cimetidine. Ann Intern Med. 1982;96:126. doi: 10.7326/0003-4819-96-1-126_2 ... To the editor: Increasingly frequent reports have attributed neurologic complications other than encephalopathy to cimetidine ... Barium swallow had shown a duodenal ulcer 11 months previously; therapy included cimetidine, ... I wish to report a case of chorea apparently caused by cimetidine. ...
Cisapride and cimetidine in the treatment of erosive esophagitis. Download Prime PubMed App to iPhone, iPad, or Android ... cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not significantly ... cimetidine 1600 mg and cimetidine 800 mg. Improvement in reflux symptoms in the two cisapride groups was not significantly ... CimetidineCisaprideDouble-Blind MethodDrug Administration ScheduleEsophagitis, PepticFemaleGastrointestinal MotilityHumansMale ...
... cimetidine) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. ... cimetidine (Tagamet, Tagamet HB). Brand Names: Tagamet, Tagamet HB. Generic Name: cimetidine. *What is cimetidine (Tagamet, ... Cimetidine is a stomach acid reducer that is used to treat and prevent certain types of stomach ulcer. Cimetidine is also used ... Cimetidine is usually taken with meals or at bedtime.. To prevent heartburn from foods or beverages, take cimetidine within 30 ...
cimetidine aldosterone renin cortisol blood pressure aldosterone release This is a preview of subscription content, log in to ... The administration of cimetidine did not induce a significant change in plasma aldosterone level or in its major controlling ... To evaluate the possible involvement of H2-histaminergic receptors, the effect of intravenous injection of 400 mg cimetidine on ... Freely J, Robertson D, Island DP, Wood AJJ (1982) Cimetidine alters plasma catecholamine levels and cortisol and aldosterone ...
  • What are the possible side effects of cimetidine (Tagamet, Tagamet HB)? (emedicinehealth.com)
  • The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach. (curehunter.com)
  • The hepatoprotective effects of cimetidine, ranitidine and famotidine against hepatotoxicity induced by carbon tetrachloride (CCl(4) ) were determined by measuring the levels of serum enzymes alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities in mice. (nih.gov)
  • Competitive inhibition alone, therefore, does not adequately explain the clinically observed effects of cimetidine on impaired CYP2D6-mediated drug clearance. (aspetjournals.org)
  • Here, we investigated the effects of cimetidine on growth and perineural/neural invasion of salivary gland tumor cells. (biomedcentral.com)
  • We also demonstrated that these apoptotic effects of cimetidine might occur through down-regulation of the cell surface expression of NCAM on HSG cells. (biomedcentral.com)
  • The beneficial effects of cimetidine in the treatment of colon cancer are well documented. (rifedigital.net)
  • citation needed] Following administration of cimetidine, the elimination half-life and area-under-curve of zolmitriptan and its active metabolites were roughly doubled. (wikipedia.org)
  • A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine. (springer.com)
  • The administration of cimetidine did not induce a significant change in plasma aldosterone level or in its major controlling factors. (springer.com)
  • On successive days, 9h creatinine clearances were measured, first without and then with the oral administration of cimetidine (400mg as a priming dose, followed by 200mg every 3h). (portlandpress.com)
  • A further group of five patients with fully compensated cirrhosis underwent the measurement (on successive days) of plasma inulin clearance, first without and then with the oral administration of cimetidine (same schedule of drug administration). (portlandpress.com)
  • has been shown to be reduced 30 to 50% by concurrent administration of cimetidine. (aspetjournals.org)
  • These findings suggest that growth and perineural/neural invasion of salivary gland tumors can be blocked by administration of cimetidine via induction of apoptosis and in which NCAM plays a role. (biomedcentral.com)
  • This study will assess the effect of cimetidine on the pharmacokinetics (PK) of dexpramipexole in healthy volunteer and evaluate the safety and tolerability of dexpramipexole when given with or without cimetidine. (clinicaltrials.gov)
  • To assess the effect of cimetidine on the pharmacokinetics (PK) of dexpramipexole in healthy volunteers. (clinicaltrials.gov)
  • Bartle WR, Walker SE, Shapero T. Dose-dependent effect of cimetidine on phenytoin kinetics. (springer.com)
  • To assess the effect of cimetidine (10 mg/kg twice daily), the drug was given with albendazole (20 mg/kg). (ajtmh.org)
  • Protective effect of cimetidine in carbon tetrachloride-treated rats. (alliedacademies.org)
  • Effect of cimetidine or ranitidine pretreatment on hepatic mixed function oxidase activity in the rat. (aspetjournals.org)
  • In this study, we have examined the effect of cimetidine on cancer cell adhesion to neural cells in vitro , one of the critical steps of cancer invasion and metastasis. (biomedcentral.com)
  • We have also used an in vivo carcinogenesis model to confirm the effect of cimetidine. (biomedcentral.com)
  • In 1988 a prospective, randomized, placebo controlled study investigated the effect of cimetidine on the survival of 181 patients with gastric cancer. (rifedigital.net)
  • Cimetidine is also used sometimes to treat stress ulcers, hives and itching, and viral warts, and to prevent aspiration pneumonia during anesthesia. (medlineplus.gov)
  • Cimetidine is used to inhibit stomach acid production and is used in the treatment of heartburn and peptic ulcers. (wikipedia.org)
  • Cimetidine is used to treat stomach and duodenal ulcers , reflux of stomach acid into the esophagus, and Zollinger-Ellison syndrome. (adventisthealthcare.com)
  • Cimetidine is a powerful H2 receptor antagonist originally designed to treat ulcers by blocking the acid producing cells in the stomach. (rxpgnews.com)
  • Cimetidine is also used to prevent ulcers in certain circumstances and to treat certain conditions that are associated with oversecretion of acid by the stomach (i.e. (medbroadcast.com)
  • Endoscopy did not show any significant differences among the four groups, although cisapride tended to be more effective in moderate to severe esophagitis, in which cases mucosal healing (i.e. absence of erosions and ulcers) was observed in 69%, 64%, 55% and 55% of the patients treated with cisapride 40 mg, cisapride 20 mg, cimetidine 1600 mg and cimetidine 800 mg. (unboundmedicine.com)
  • Cimetidine (200mg) is a histamine H2-receptor antagonist, prescribed for heartburn and peptic ulcers. (medindia.net)
  • Before giving cimetidine to patients with gastric ulcers the possibility of malignancy should be considered since cimetidine may mask symptoms and dely diagnosis. (worldbid.com)
  • 2.Cimetidine, Ranitidine or Famotidine may be administered to treat peptic ulcers or hypersecretory states. (pharmainfo.net)
  • Cimetidine may be used to aid in the treatment of existing ulcers and help prevent ulcer development. (valleyvet.com)
  • Cimetidine is used to treat equine gastric ulcers, often found in foals and race horses, which are two populations with a higher risk for gastric ulcers than other horses. (equimed.com)
  • After a diagnosis of ulcers, cimetidine is usually prescribed for two to three weeks to give the ulcers time to heal. (equimed.com)
  • Cimetidine is sometimes prescribed as a precaution to be used with nonsteroidal anti-inflammatory drugs, corticosteroids, and other drugs that can cause gastric ulcers. (equimed.com)
  • Uses/Indications - In veterinary medicine, cimetidine has been used for the treatment and/or prophylaxis of gastric, abomasal and duodenal ulcers, uremic gastritis, stress-related or drug-induced erosive gastritis, esophagitis, duodenal gastric reflux and esophageal reflux. (elephantcare.org)
  • The recommended dose of cimetidine to treat ulcers caused by anti-inflammatory medications is 800 mg daily, either as 400 mg taken twice a day or 800 mg taken at bedtime. (rxhealthmed.ca)
  • Studies have shown that cimetidine inhibits both daytime and nocturnal basal gastric acid secretion. (nih.gov)
  • Cimetidine also inhibits gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine and insulin. (nih.gov)
  • An 800 mg oral dose of cimetidine at bedtime reduces mean hourly H + activity by greater than 85% over an eight-hour period in duodenal ulcer patients, with no effect on daytime acid secretion. (nih.gov)
  • Cimetidine given as 400 mg twice daily and 300 mg four times daily decreases nocturnal acid secretion in a dose-related manner, i.e., 47% to 83% over a six- to eight-hour period and 54% over a nine-hour period, respectively. (nih.gov)
  • The effect of a 300 mg breakfast dose of cimetidine continued for at least four hours and there was partial suppression of the rise in gastric acid secretion following the luncheon meal in duodenal ulcer patients. (nih.gov)
  • Cimetidine is a potent inhibitor of tubular creatinine secretion. (wikipedia.org)
  • Cimetidine is a histamine H 2 -receptor antagonist which inhibits gastric acid secretion. (inchem.org)
  • Cimetidine, an H-2 antihistamine stimulates prolactin secretion in man. (springer.com)
  • Freely J, Robertson D, Island DP, Wood AJJ (1982) Cimetidine alters plasma catecholamine levels and cortisol and aldosterone secretion. (springer.com)
  • Cimetidine inhibits the tubular secretion of creatinine, without altering the glomerular filtration rate (GFR). (portlandpress.com)
  • We determined the clearance of lithium (an index of fluid delivery to the distal nephron), inulin (a measure of the actual GFR) and creatinine during cimetidine administration to investigate the occurrence of tubular creatinine secretion in patients with compensated cirrhosis. (portlandpress.com)
  • Although both doses of Cimetidine reduced the acid secretion significantly, no reduction in the steatorrhea and creatorrhea or increase in weight were found, although less pancreatin seemed to be inactivated while on cimetidine. (biomedsearch.com)
  • a) Cimetidine, the first H2-receptor antagonist approved for clinical use, reduces gastric acid secretion by about 50% (at a total daily dosage of 1000mg). (pharmainfo.net)
  • Compared with cimetidine, SKF92374 showed very weak activity (400-fold lower affinity) on H2 receptors in vitro (isolated guinea pig atrium) and in vivo (rat gastric secretion). (aspetjournals.org)
  • Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine. (bmj.com)
  • Gastric emptying time, pancreatic or biliary secretion, and lower esophageal pressures are not altered by cimetidine. (elephantcare.org)
  • Cimetidine when given as an intravenous bolus, stimulates the secretion of Prolactin, but other pituitary hormones are not affected. (ailment.info)
  • Since cimetidine is so well known as an H2 blocker medication to reduce stomach acid secretion, its role in cancer treatment has been grossly overlooked. (rifedigital.net)
  • Cimetidine is a histamine H 2 -receptor ant agonist which rapidly inhibits both basal and stimulated gastric secretion of acid and reduces pepsin output. (pharma-voice.com)
  • The effects of two doses orally administered Cimetidine on gastric and acid production and on intestinal absorption in 13 patients with cystic fibrosis who were treated with pancreatin supplementation were studied. (biomedsearch.com)
  • The effect of two doses of cimetidine, 400 mg at night and 400 mg bd, on the protection of indomethacin (50 mg tid) induced mucosal damage was evaluated in a double blind study in patients with acute musculoskeletal disorders. (bmj.com)
  • Drug side effects are rare, but cimetidine should be used with caution or in smaller doses in horses with decreased liver or kidney function. (equimed.com)
  • Some veterinarians recommend separating oral doses of cimetidine from antacids, metoclopramide, and sucralfate. (equimed.com)
  • The six doses, separated at intervals of 12 hours, sum 37.86 mg/kg cimetidine. (alliedacademies.org)
  • The dose of cimetidine administered in rats in the present paper is close to or lower compared to the doses mentioned in other researchers [ 6 ]. (alliedacademies.org)
  • Cimetidine has also been used investigationally as a immunomodulating agent (see doses) in dogs. (elephantcare.org)
  • Patients were given 6 doses of cimetidine, 400 or 800 mg, and 6 placebo doses, with the order randomized in pairs. (acpjc.org)
  • This study compared the effect of single equimolar oral doses of cimetidine (100 mg/kg) or ranitidine (139 mg/kg) on rat hepatic mixed function oxidases. (aspetjournals.org)
  • Dosage of cimetidine hydrochloride expressed in terms of cimetidine. (drugs.com)
  • One hundred and twenty-nine patients were assigned to one of four dosage schedules: cisapride 10 mg b.i.d. (20 mg group) or q.i.d. (40 mg group), or cimetidine 400 mg b.i.d. (800 mg group) or q.i.d. (1600 mg group). (unboundmedicine.com)
  • Adverse reactions to cimetidine are generally infrequent and ars usually reversible following a reduction of dosage or wrthdrawal of therapy. (worldbid.com)
  • The dosage form available for Phenylbutazone/Cimetidine is Oral Powder. (wedgewoodpharmacy.com)
  • If you are unsure about anything related to cimetidine or your cimetidine dosage, please talk to your doctor, nurse, or pharmacist. (emedtv.com)
  • TAGAMET (Cimetidine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance. (nativeartscircle.org)
  • Take cimetidine exactly as directed. (medlineplus.gov)
  • How should I take cimetidine (Tagamet, Tagamet HB)? (emedicinehealth.com)
  • To prevent heartburn from foods or beverages, take cimetidine within 30 minutes before eating or drinking. (emedicinehealth.com)
  • Ask your healthcare provider about how long you will need to take cimetidine. (emedtv.com)
  • Some people only need to take cimetidine for a short period of time (a month or two). (emedtv.com)
  • You may take cimetidine with or without food. (emedtv.com)
  • If you take cimetidine daily, you should take it at the same time(s) each day to maintain an even level of the drug in your blood. (emedtv.com)
  • If you take cimetidine just once a day, it is usually best to take it at bedtime. (emedtv.com)
  • However, many people need to take cimetidine only until their ulcer or esophagitis is healed. (emedtv.com)
  • Many people take cimetidine only when they need it. (emedtv.com)
  • Drug information on Cimetidine (200mg) (Cimetidine) from Zydus Cadila Healthcare Ltd. (medindia.net)
  • How to use Cimetidine (200mg)? (medindia.net)
  • When is Cimetidine (200mg) not to be taken? (medindia.net)
  • A 1600 mg oral dose of cimetidine at bedtime produces 100% inhibition of mean hourly H + activity over an eight-hour period in duodenal ulcer patients, but also reduces H + activity by 35% for an additional five hours into the following morning. (nih.gov)
  • This suppression of gastric acid output was enhanced and could be maintained by another 300 mg dose of cimetidine given with lunch. (nih.gov)
  • In another study, a 300 mg dose of cimetidine given with the meal increased gastric pH as compared with placebo. (nih.gov)
  • Dose related in vitro effects of ranitidine and cimetidine on basal and ACTH-stimulated steroidogenesis. (springer.com)
  • The usual recommended adult dose of cimetidine ranges from 200 mg twice a day to 600 mg 4 times a day (usually with meals and at bedtime), depending on the condition being treated. (medbroadcast.com)
  • The maximum recommended dose of cimetidine is 2,400 mg. (medbroadcast.com)
  • This open-label study assesses the single-dose pharmacokinetics of intravenously-administered MNTX in healthy adult male and female subjects in the absence of, and in the presence of, orally-administered cimetidine. (clinicaltrials.gov)
  • Effect of dose increase or cimetidine co-administration on albendazole bioavailability. (ajtmh.org)
  • On both the hot-plate and tail-flick nociceptive tests, cimetidine and SKF92374 induced complete, dose-related analgesic responses when injected into the lateral ventricle of rats. (aspetjournals.org)
  • SKF92374 showed strong similarities to cimetidine in analgesic efficacy, slope of dose-response curves and chemical structure, suggesting that these compounds share a common analgesic mechanism. (aspetjournals.org)
  • Single-dose studies of theophylline pharmacokinetics were performed at base line and on the fifth day of each of three treatment regimens consisting of 400 mg cimetidine every 12 hr, 500 mg ciprofloxacin every 12 hr and the combination of cimetidine and ciprofloxacin. (aspetjournals.org)
  • The typical dose of cimetidine that healthcare providers recommend for pathological hypersecretory conditions (such as Zollinger-Ellison syndrome) is cimetidine 300 mg four times daily. (emedtv.com)
  • If necessary, your healthcare provider may increase your dose up to a total of cimetidine 2400 mg per day. (emedtv.com)
  • People who have poor kidney function (including kidney failure or renal failure) need to take a lower dose of cimetidine. (emedtv.com)
  • If you have kidney problems, ask your healthcare provider about which dose of cimetidine you should be taking. (emedtv.com)
  • The dose of 25 μmoli/kg match to 6.31 mg/kg cimetidine. (alliedacademies.org)
  • However, for those who take it on a daily basis, if you do not take your cimetidine as scheduled, take your next dose as soon as you remember. (emedtv.com)
  • Do not take a double dose of cimetidine. (emedtv.com)
  • The recommended adult dose of cimetidine depends on the condition being treated. (rxhealthmed.ca)
  • If zolmitriptan tablets is co-administered with cimetidine, limit the maximum single dose of zolmitriptan tablets to 2.5 mg, not to exceed 5 mg in any 24-hour period [see DRUG INTERACTIONS , CLINICAL PHARMACOLOGY ]. (rxlist.com)
  • They were given either cimetidine at a dose of 400 mg twice daily or placebo for two years or until death. (rifedigital.net)
  • Due to its non-selective inhibition of cytochrome P450 enzymes, cimetidine has numerous drug interactions. (wikipedia.org)
  • Boidin MP, Stuurman A, Erdmann W. Inhibition of steroidogenesis by cimetidine in man. (springer.com)
  • Thus, the response to inhibition of theophylline metabolism by cimetidine and ciprofloxacin is not influenced by age or gender. (aspetjournals.org)
  • Cimetidine has been associated with many drug-drug interactions, some of which are thought to involve inhibition of cytochrome P450 (P450 1 ) enzymes (reviewed in Somogyi and Gugler, 1982 ). (aspetjournals.org)
  • There is evidence to suggest that cimetidine may be able to alter P450 activity by a mechanism other than reversible inhibition. (aspetjournals.org)
  • We have recently reported, using isolated membrane vesicles, that these two types can be differentiated by their relative sensitivities to inhibition by clonidine and cimetidine [Kulanthaivel, Leibach, Mahesh, Cragoe & Ganapathy (1990) J. Biol. (biochemj.org)
  • Inhibition studies with clonidine and cimetidine were able to differentiate between these two exchangers very clearly. (biochemj.org)
  • It is concluded that the relative susceptibility to inhibition by clonidine and cimetidine offers an easy and efficient means of differentiating between the two types of Na(+)-H+ exchangers in cultured cells. (biochemj.org)
  • The mechanism of action of cimetidine as an antacid is as a histamine H2 receptor antagonist. (wikipedia.org)
  • Randomized prospective evaluation of cimetidine and antacid control of gastric pH in the critically ill. (semanticscholar.org)
  • One hundred forty-four critically ill patients admitted to an intensive care setting were randomly assigned to cimetidine or antacid treatament groups. (semanticscholar.org)
  • Though the patient may take an antacid to treat pain, simultaneous use of antacids is not recommended as antacids may interfere with the absorption of cimetidine. (ailment.info)
  • It cannot be replaced with Ranitidine or any other antacid medication: see the description for cimetidine in this article. (wikibooks.org)
  • Given the less-than-ideal effects of antacid preparations, the advent of the H2RAs cimetidine, ranitidine, famotidine, and nizatidine provide some improvement for the treatment of GERD. (nativeartscircle.org)
  • Cimetidine is also used to treat gastroesophageal reflux disease ( GERD ), when stomach acid backs up into the esophagus and causes heartburn . (emedicinehealth.com)
  • If you experience the burning sensations of gastroesophageal reflux disease, commonly called GERD, your doctor may recommend a prescription for Tagamet or generic Cimetidine to help calm the acid production in your stomach. (discountdrugsfromcanada.com)
  • The proven mechanisms of action of cimetidine suggest that alone it would significantly alter the ability of certain colon cancers to grow and metastasize, however, further studies should be done to evaluate and document the efficacy of cimetidine on its own. (rifedigital.net)
  • Comparative efficacy of cimetidine & ranitidine. (bvsalud.org)
  • Cimetidine competitively inhibits the action of histamine at the histamine H 2 -receptors of the parietal cells and thus is a histamine H 2 -receptor antagonist. (nih.gov)
  • Pharmacology - At the H 2 receptors of the parietal cells, cimetidine competitively inhibits histamine, thereby reducing gastric acid output both during basal conditions and when stimulated by food, pentagastrin, histamine or insulin. (elephantcare.org)
  • What is the most important information I should know about cimetidine (Tagamet, Tagamet HB)? (emedicinehealth.com)
  • What should I discuss with my healthcare provider before taking cimetidine (Tagamet, Tagamet HB)? (emedicinehealth.com)
  • Over-the-counter cimetidine is available as Tagamet HB 200 mg tablets. (emedtv.com)
  • This class includes Tagamet HB (cimetidine), Pepcid (famotidine) and Zantac (ranitidine). (thefreedictionary.com)
  • The development of longer-acting H2 receptor antagonists with fewer drug interactions and adverse effects, such as ranitidine and famotidine, decreased the use of cimetidine, and though it is still used, cimetidine is no longer among the more widely used of the H2 receptor antagonists. (wikipedia.org)
  • This review article recapitulates the analytical methods for the quantitative determinations of diltiazem and three H 2 receptor antagonists (cimetidine, ranitidine, and famotidine) by one of the spectroscopic technique (UV spectrophotometery) and separation technique such as high-performance liquid chromatography (HPLC). (hindawi.com)
  • Histamine H 2 receptor antagonists: cimetidine (CIM), ranitidine (RAN), and famotidine (FAM) classified as class III drugs (high solubility, low permeability) according to the Biopharmaceutics Classification System (BCS) [ 3 , 4 ] are used in the treatment of gastrooesophageal reflux disease and gastric and duodenal ulceration [ 5 ]. (hindawi.com)
  • The present review article deals with the analytical methods that are useful for pure form, pharmaceutical formulations, and biological specimens of diltiazem and H 2 receptor antagonists (cimetidine, ranitidine, and famotidine) were focused and summarized. (hindawi.com)
  • Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. (nih.gov)
  • We found that the IC(50) values of cimetidine, ranitidine and famotidine on DPPH radical-scavenging activity were 671±28, 538±21 and 955±43 μg/mL, respectively. (nih.gov)
  • Pretreatment of mice with cimetidine, ranitidine or famotidine for three consecutive days reduced CCl(4)-induced hepatotoxicity in mice. (nih.gov)
  • Treatment with 200 mg/kg ranitidine reduced AST, AST and ALP serum levels, while 200 and 40 mg/kg of cimetidine and famotidine, respectively, reduced AST and ALP serum levels. (nih.gov)
  • Drug Advice: CIMETIDINE, RANITIDINE, FAMOTIDINE Pharmaceutical Information by Santosh kumar. (pharmainfo.net)
  • 2.If you are taking antacids, do not take them within 1hour of cimetidine, ranitidine or famotidine. (pharmainfo.net)
  • 7.If ranitidine or famotidine or cimetidine and ketoconazole are to be taken together, they should be taken at least 2 hours after ketoconazole. (pharmainfo.net)
  • Dear santosh, Can you please explain the reason behind this statement, "7.If ranitidine or famotidine or cimetidine and ketoconazole are to be taken together, they should be taken at least 2 hours after ketoconazole. (pharmainfo.net)
  • However, because cimetidine doesn't interact well with amlodipine, a high blood pressure drug, or diazepam, which is used to stimulate a cat's appetite, your vet may use famotidine or ranitidine instead. (thenest.com)
  • Cimetidine (CIM) is a histamine H 2 -receptor antagonist (H 2 RA), in the same class as ranitidine, famotidine, and nizatidine. (ecancer.org)
  • Cimetidine Tablets may be used to reduce stomach acid production in horses, dogs and cats. (valleyvet.com)
  • Cimetidine Tablets may be used in the treatment of reflux or to reduce inflammation of the esophagus or stomach. (valleyvet.com)
  • Do not take more than two over-the-counter cimetidine tablets in a 24-hour period. (emedtv.com)
  • A liquid form of prescription cimetidine is available for people who have trouble swallowing tablets. (emedtv.com)
  • Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain cimetidine as novel drug. (hud.ac.uk)
  • In vitro drug release studies reveal that grewia gum can control the release of cimetidine from tablets for up to 12 hours. (hud.ac.uk)
  • There was synergy between grewia gum and HPMC in delaying the release of cimetidine from tablets. (hud.ac.uk)
  • Currently, generic prescription cimetidine tablets, cimetidine solution, and over-the-counter cimetidine tablets are licensed for sale. (emedtv.com)
  • Examples of specific interactions include the following: Cimetidine affects the metabolism of methadone, sometimes resulting in higher blood levels and a higher incidence of side effects, and may interact with the antimalarial medication hydroxychloroquine. (wikipedia.org)
  • The data suggest that short-term treatment with cimetidine could potentially perturb vitamin D metabolism in man. (nih.gov)
  • Cimetidine-induced decrease in lidocaine metabolism. (springer.com)
  • Cimetidine may slow the metabolism of other drugs that are metabolized by the liver. (equimed.com)
  • 300 mg of cimetidine taken orally reduced total pepsin output as a result of the decrease in volume of gastric juice. (nih.gov)
  • Nine adult patients were treated with 400 mg cimetidine orally twice daily during a period from winter to summer, when days were becoming longer. (nih.gov)
  • When Cimetidine is taken orally, no effect on Prolactin levels is observed. (ailment.info)
  • Omeprazole is more effective than cimetidine in the prevention of recurrence of GERD-associated heartburn and the occurrence of underlying oesophag. (nih.gov)
  • There is also a paucity of data on the long-term use of cimetidine in GERD patients. (nih.gov)
  • Find out what are the side effects, uses, dangers, warnings, and precautions of Cimetidine vs Ranitidine, two popular medicine used to treat GERD. (nativeartscircle.org)
  • Cimetidine is taken for treating GERD. (nativeartscircle.org)
  • 182 patients conversations about taking Cimetidine for GERD. (nativeartscircle.org)
  • Improvement in reflux symptoms in the two cisapride groups was not significantly different from that in the cimetidine 1600 mg group, but was better (p less than 0.05) than that in the cimetidine 800 mg patients. (unboundmedicine.com)
  • Cimetidine significantly (p less than 0.05) increased hexobarbital sleeping time and prolonged aminopyrine and theophylline elimination. (aspetjournals.org)
  • Aminopyrine N-demethylase activity in vitro was significantly (p less than 0.05) inhibited by cimetidine pretreatment but significantly (p less than 0.025) increased by ranitidine pretreatment. (aspetjournals.org)
  • citation needed] Clinically significant drug interactions with the CYP1A2 substrate theophylline, the CYP2C9 substrate tolbutamide, the CYP2D6 substrate desipramine, and the CYP3A4 substrate triazolam have all been demonstrated with cimetidine, and interactions with other substrates of these enzymes are likely as well. (wikipedia.org)
  • Somogy A, Gugler R. Drug interactions with cimetidine. (springer.com)
  • Cimetidine-theophylline interactions: report of four patients. (springer.com)
  • In vivo, this postulated mechanism is supported by a delay in the onset of cimetidine drug-drug interactions. (aspetjournals.org)
  • Find patient medical information for Cimetidine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. (nativeartscircle.org)
  • The study found that those given cimetidine had a significantly prolonged survival rate particularly in patients with more serious (stage II and IV) disease.1 This finding is especially notable in light of what we know today about the mechanism of action of cimetidine. (rifedigital.net)
  • The results of this study showed that cimetidine inhibited mixed function oxidases, whereas ranitidine had no effect or tended to stimulate mixed function oxidases. (aspetjournals.org)
  • Cimetidine comes as a tablet and a liquid to take by mouth. (medlineplus.gov)
  • Each film-coated tablet, for oral administration, contains 300 mg, 400 mg or 800 mg of cimetidine. (nih.gov)
  • Each pale green, round, scored tablet with 'novo' over '300' on one side, contains cimetidine 300 mg. (medbroadcast.com)
  • Each pale green, oval shaped tablet with 'novo' on one side and '400' on the other side contains cimetidine 400 mg. (medbroadcast.com)
  • Cimetidine is available in tablet, liquid and injectable forms. (thenest.com)
  • Although cimetidine can be nitrosated in vitro in the presence of nitrite under acidic conditions to form N -nitrosocimetidine, no study in experimental animals or in humans has demonstrated that this reaction occurs in vivo . (inchem.org)
  • There is inadequate evidence for the carcinogenicity of cimetidine in humans. (inchem.org)
  • Cimetidine is not classifiable as to its carcinogenicity to humans (Group 3) . (inchem.org)
  • In humans, cimetidine is rapidly and well absorbed after oral administration, but a small amount is metabolized in the liver before entering the systemic circulation (first-pass effect). (elephantcare.org)
  • Cimetidine hydrochloride induced single-strand breaks and unscheduled DNA synthesis in rat but not human cells in vitro . (inchem.org)
  • Here, we examined the pharmacokinetics of a cationic drug, cimetidine, and renal rOCT2 and rMATE1 levels as well as their regulation after liver I/R. Rats were subjected to 60 min of liver ischemia followed by 12 h of reperfusion. (nii.ac.jp)
  • Gastric juice from cimetidine-treated patients was mutagenic to bacteria when enriched with nitrite. (inchem.org)
  • however, increased gastric concentrations of nitrite and total N -nitroso compounds have been reported in some studies of patients taking cimetidine. (inchem.org)
  • The study was conducted in surgical patients under anaesthesia, in which steroidogenesis was inhibited by cimetidine. (springer.com)
  • All patients were in symptomatic remission following 4 weeks of omeprazole 20 mg o.d. or cimetidine 400 mg q.d.s. and, if required, a further 4 weeks of omeprazole 20 mg o.d. (nih.gov)
  • Patients were randomized to receive, double-blind, either omeprazole 10 mg o.m. (n = 77) or cimetidine 800 mg nocte (n = 79) for 24 weeks. (nih.gov)
  • During cimetidine administration the creatinine/inulin clearance ratio approaches unity in patients with renal failure. (portlandpress.com)
  • Cimetidine caused no significant decrease in the actual GFR (i.e. inulin clearance) when administered to the second group of patients with compensated cirrhosis. (portlandpress.com)
  • Cimetidine is contraindicated for patients known to have hypersensitivity to the product. (pediatriconcall.com)
  • Cimetidine decreases indomethacin induced duodenal mucosal damage in patients with acute musculoskeletal disorders. (bmj.com)
  • n = 42) was significantly lower (p less than 0.0122) than in placebo treated patients: 6.1 (0.9) (n = 50) or in patients treated with cimetidine 400 mg at night 7.1 (0.8) (n = 21). (bmj.com)
  • Incidence of pneumonia in mechanically ventilated patients treated with sucralfate or cimetidine as prophylaxis for stress bleeding: bacterial colonization of the stomach. (biomedsearch.com)
  • In a prospective study we investigated 104 mechanically ventilated patients in the intensive care unit who were receiving sucralfate (n = 49) or cimetidine (n = 55) for stress ulcer prophylaxis. (biomedsearch.com)
  • Mortality rates were 18.4% (9 patients) in the sucralfate group versus 25.5% (14 patients) in the cimetidine group (p = 0.48). (biomedsearch.com)
  • The mean pH values of gastric aspirates were significantly lower in patients treated with sucralfate than in patients receiving cimetidine (p = 0.044). (biomedsearch.com)
  • To identify individual responders to on-demand cimetidine therapy for nonulcer dyspepsia and compare them with patients taking cimetidine for endoscopically proven peptic ulcer and esophagitis. (acpjc.org)
  • Cimetidine was effective for ameliorating persistent symptoms in individual patients with nonulcer dyspepsia, peptic ulcer, or esophagitis. (acpjc.org)
  • Use of cimetidine in pediatric patients is not recommended unless the anticipated benefits outweigh the potential risk. (ailment.info)
  • The results of a brand new study on colon cancer patients may provide enough compelling evidence to convince oncologists that cimetidine is an effective adjuvant therapy. (rifedigital.net)
  • In 1994, a study was performed that demonstrated that just seven days of treatment with cimetidine (five days pre-operative and two days post-operative) decreased the three-year mortality rate from 41% to 7% in colorectal cancer patients. (rifedigital.net)
  • After surgery to remove the primary tumor followed by IV Mitomycin chemotherapy, all patients were given either 200 mg of oral 5-FU or 200 mg of 5-FU with 800 mg of oral cimetidine daily for 12 consecutive months. (rifedigital.net)
  • The study showed a more than three-fold improvement in 10-year survival of Dukes C colon cancer patients who were given cimetidine. (rifedigital.net)
  • In one cimetidine trial, the ten-year survival rate of patients who had undergone the surgical removal of a colorectal cancer was increased from 49.8% to 84.6% when they were treated for a year after with cimetidine as an adjuvant to the chemotherapy agent 5-fluorouracil. (rifedigital.net)
  • Other trials have also demonstrated significantly enhanced survival rates when patients have received cimetidine. (rifedigital.net)
  • Cimetidine inhibits ALA synthase activity and hence may have some therapeutic value in preventing and treating acute porphyria attacks. (wikipedia.org)
  • Fourthly, the prescriber needs to be aware that cimetidine may produce higher plasma concentrations of some drugs which have a fairly narrow therapeutic range, and this may be clinically important. (springer.com)
  • Horse owners and handlers should check with a knowledgeable veterinarian and the individual regulatory group regarding rules for therapeutic use of cimetidine. (equimed.com)
  • Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. (ecancer.org)
  • Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups. (aspetjournals.org)
  • With human liver microsomes, cimetidine competitively inhibited CYP2D6 ( K i = 38 ± 5 μM) and was a mixed inhibitor of recombinant CYP2D6 ( K i = 103 ± 17 μM). (aspetjournals.org)
  • Cimetidine has been shown to act as a selective and potent inhibitor of rat CYP2C11 through the formation of a metabolite-intermediate complex. (aspetjournals.org)
  • 1. Adding cimetidine, which is a cytochrome p450 inhibitor (see the description for cimetidine in this article), would almost double the amitriptyline blood levels and would potentiate it that much, that it would hasten death by far. (wikibooks.org)
  • These effects probably arise from the multiple actions of cimetidine as an H2 receptor antagonist, an immunomodulator and as an inhibitor of adhesion molecule expression, but it is not yet approved by the FDA for use in these diseases. (rifedigital.net)
  • Cimetidine may decrease the effects of CYP2D6 substrates that are prodrugs, such as codeine, tramadol, and tamoxifen. (wikipedia.org)
  • Cimetidine, which reduces stomach acid, may decrease the amount of vitamin B12 available for the body to absorb. (adventisthealthcare.com)
  • Cimetidine may decrease the clearance of caffeine from the body, causing increased caffeine blood levels and unwanted actions. (adventisthealthcare.com)
  • This investigation proved that ascorbic acid can prevent cimetidine-induced decrease of human serum hydrocortisone concentrations. (springer.com)
  • Cimetidine tended to decrease Cmax by 52% (P = 0.109) and significantly inhibited ABZSX breakdown as indicated by the prolongation of ABZSX elimination half-life from 7.4+/-3.3 hr to 19.0+/-11.7 hr (P = 0.028). (ajtmh.org)
  • Individually, cimetidine and ciprofloxacin produced proportionate declines in plasma theophylline clearance that were similar among the four groups (range, 23.4-32.7% decrease). (aspetjournals.org)
  • The direct addition of cimetidine or SKF 525A to the 10,000g supernatant fraction from controlled liver homogenates decreased aminopyrine N-demethylase activity, whereas the direct addition of ranitidine tended to increase aminopyrine N-demethylase activity. (aspetjournals.org)
  • Interestingly, the less aggressive forms of colon cancer (Duke A or B) did not respond as remarkably to the addition of cimetidine in this study as the more aggressive Dukes C. (rifedigital.net)
  • Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. (ecancer.org)
  • In a study in which mice were exposed from conception throughout life to a combination of cimetidine and sodium nitrite, males had an increased incidence of lung neoplasms, although these tumours also occurred at a high frequency in control animals. (inchem.org)
  • Read user comments about the side effects, benefits, and effectiveness of cimetidine oral. (webmd.com)
  • Cimetidine reduces the absorption of ketoconazole and itraconazole (which require a low pH). (wikipedia.org)
  • b)Antacids impair absorption of cimetidine and ranitidine and should be given 1 hour apart from these drugs. (pharmainfo.net)
  • d)Cimetidine interferes with absorption or excretion of ketoconazole, nifedipine and procainamide. (pharmainfo.net)
  • tell your doctor and pharmacist if you are allergic to cimetidine or any other medications. (medlineplus.gov)
  • Do not take this medication if you are allergic to cimetidine or any ingredients of the medication. (rxhealthmed.ca)
  • Cimetidine inhibits the renal excretion of metformin and procainamide, resulting in increased circulating levels of these drugs. (wikipedia.org)
  • The systemic and tubular secretory clearances of cimetidine (78% and 55%) as well as renal rOCT2 and rMATE1 levels (67% and 61%) in I/R rats were decreased compared with those in sham-operated rats, respectively. (nii.ac.jp)
  • Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. (wikipedia.org)
  • Cimetidine is a stomach acid reducer that is used to treat and prevent certain types of stomach ulcer . (emedicinehealth.com)
  • CIMETIDINE (sye MET i deen) is a type of antihistamine that blocks the release of stomach acid. (aarpmedicareplans.com)
  • Cimetidine (brand name Tagamet®) is a drug historically used to reduce stomach acid production. (rifedigital.net)
  • Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. (nativeartscircle.org)
  • Cimetidine dosed at 800 mg at bedtime, 400 mg twice daily, and 300 mg four times daily, all provide a similar, moderate (less than 60%) level of 24-hour acid suppression. (nih.gov)
  • Cimetidine is usually taken with meals or at bedtime. (emedicinehealth.com)
  • If the anti-inflammatory is not stopped, the cimetidine may be continued as 400 mg at bedtime. (rxhealthmed.ca)
  • Cimetidine is soluble in alcohol, slightly soluble in water, very slightly soluble in chloroform and insoluble in ether. (nih.gov)
  • Cimetidine is sparingly soluble in water and soluble in alcohol. (elephantcare.org)
  • Cimetidine HCl occurs as white, crystalline powder and is very soluble in water and soluble in alcohol. (elephantcare.org)
  • Cimetidine is in a class of medications called H 2 blockers. (medlineplus.gov)
  • Cimetidine can also interact with a number of psychoactive medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors, causing increased blood levels of these drugs and the potential of subsequent toxicity. (wikipedia.org)
  • Like several other medications (e.g. erythromycin), cimetidine interferes with the body's metabolization of sildenafil, causing its strength and duration to increase (therefore also its side effects to be more likely and prominent). (wikipedia.org)
  • Among the medications with possible impact on the evolution, cimetidine (CM) can favorably intervene through multiple effects in CT induced toxic hepatitis [ 5 ]. (alliedacademies.org)
  • Cimetidine, the generic name for the Tagamet brand, is one of those medications. (thenest.com)
  • In the following year, he was treated with several antireflux medications including cimetidine, ranitidine. (nativeartscircle.org)
  • You should not use ketoconazole within 2 hours before or after taking cimetidine. (stlukes-stl.com)
  • Therefore, cimetidine may represent a class of compounds capable of inactivating specific cytochromes P450 in vivo, but for which conditions may not be achievable in vitro using human liver microsomes. (aspetjournals.org)
  • Cimetidine was approved in the United Kingdom in 1976, and was approved in the United States by the Food and Drug Administration for prescriptions in 1979. (wikipedia.org)
  • These reports are difficult to interpret because gastric cancer is a common malignancy and cimetidine is a commonly used drug, and coincidence cannot be ruled out. (inchem.org)
  • Cimetidine is available as a prescription drug and as a nonprescription over-the-counter product for relief of heartburn . (adventisthealthcare.com)
  • Differential effect of cimietidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine. (springer.com)
  • Secondly Cimetidine is a drug generally not used these days because of its side effects may be because of its modest affinity towards androgen receptors. (pharmainfo.net)
  • Use of cimetidine is forbidden in drug-free competition. (equimed.com)
  • Cimetidine was one of the first drugs of this type on the market but, according to the Veterinary Drug Handbook, vets use cimetidine less frequently now that other H-2 blockers are available. (thenest.com)
  • Cimetidine is not FDA-approved for treating animals, but vets are legally allowed to prescribe it as an "extra-label" drug. (thenest.com)
  • The Veterinary Drug Handbook suggests you ask the pharmacist to add a pleasant flavor to the cimetidine solution as a way of making it less objectionable for your cat. (thenest.com)
  • Over-the-counter cimetidine is used to prevent and treat symptoms of heartburn associated with acid indigestion and sour stomach. (medlineplus.gov)
  • If symptoms of heartburn, acid indigestion, or sour stomach last longer than 2 weeks, stop taking cimetidine and call your doctor. (medlineplus.gov)
  • Cimetidine appears to be very safe in overdose, producing no symptoms even with massive overdoses (e.g., 20 g). (wikipedia.org)
  • The severity score for all reflux symptoms had decreased by 79%, 74% (cisapride 40 mg and 20 mg), 69% and 57% (cimetidine 1600 mg and 800 mg) by the end of treatment. (unboundmedicine.com)
  • Over-the-counter cimetidine can also help relieve symptoms once they occur. (emedtv.com)
  • Johannessen and colleagues compared on-demand cimetidine with placebo in treating the symptoms of dyspepsia. (acpjc.org)
  • Cimetidine (Tagamet) is used to treat and prevent symptoms of heartburn. (nativeartscircle.org)
  • Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous double-blind clinical trials found it to be no more effective than a placebo. (wikipedia.org)
  • There is some evidence supporting the use of Cimetidine in the treatment of PFAPA. (wikipedia.org)
  • Because of its hormonal effects, cimetidine rarely may cause sexual dysfunction including loss of libido and erectile dysfunction and gynecomastia (0.1-0.2%) in males during long-term treatment. (wikipedia.org)
  • The efficacy of cisapride, as compared with cimetidine, in the treatment of erosive esophagitis was studied in a double-blind trial. (unboundmedicine.com)
  • TY - JOUR T1 - Cisapride and cimetidine in the treatment of erosive esophagitis. (unboundmedicine.com)
  • Cimetidine as an adjunct to oral enzymes in the treatment of malabsorption due to cystic fibrosis. (biomedsearch.com)
  • Cimetidine in subacute treatment, preventive, for 3 days has protective action relative to CCl4. (alliedacademies.org)
  • Cimetidine is a histamine H2-receptor antagonist for treatment of ulcus duodeni and ulcus ventriculi. (jrspharma.com)