A ciliary neurotrophic factor receptor subunit. It is anchored to the cell surface via GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and has specificity for binding to CILIARY NEUROTROPHIC FACTOR. It lacks signal transducing domains which are found on the other two subunits of the receptor.
Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
A neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system.
Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.
A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; neurotrophin 4 and neurotrophin 5. It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A federal area located between Maryland and Virginia on the Potomac river; it is coextensive with Washington, D.C., which is the capital of the United States.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Organized activities related to the storage, location, search, and retrieval of information.
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
A publication issued at stated, more or less regular, intervals.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS.
Antibodies produced by a single clone of cells.
Biologically functional sequences of DNA chemically synthesized in vitro.
Proteins prepared by recombinant DNA technology.
Hospital department responsible for the purchasing of supplies and equipment.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. (1/16)

PURPOSE: Ciliary neurotrophic factor (CNTF) promotes gene expression, cell survival and differentiation in various types of peripheral and central neurons, glia and nonneural cells. The level of CNTF rises rapidly upon injury to neural tissue, suggesting that CNTF exerts its cytoprotective effects after release from cells via mechanisms induced by cell injury. The purpose of this study was to determine if cells in the optic nerve head express CNTF and its tripartite receptor complex. METHODS: Well-established optic nerve head astrocytes (ONHA) and lamina cribrosa (LC) cell cultures were derived from normal human donors. Total RNA was reverse transcribed and polymerase chain reaction (PCR) amplified for mRNA detection. Cytoplasmic protein expression was determined by immunocytochemistry and Western blot analysis of the cellular lysates. Serum free medium was concentrated and used for detecting extracellular proteins. CNTF complexed with CNTFR-alpha was assayed by immunoprecipitation. RESULTS: Cells isolated from the human optic nerve head express CNTF and its tripartite receptor complex members (CNTFR-alpha, gp130, LIFR-beta). CONCLUSIONS: Taken together, these data suggest a possible neuroprotective role of CNTF in the optic nerve head.  (+info)

Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. (2/16)

Intrauterine nutrition status is reported to correlate with risk of cardiovascular diseases in adulthood. Either under- or overnutrition during early to mid gestation contributes to altered fetal growth and ventricular geometry. This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. Multiparous ewes were fed with 50% [nutrient-restricted (NR)], 100% (control) or 150% [overfed (OF)] of National Research Council requirements from 28 to 78 days of gestation (dG; term, 148 dG). Ewes were euthanized on Day 78, and the gravid uteri and fetuses recovered. Ventricular protein expression of CNTFRalpha, STAT3, phosphorylated STAT3, insulin-like growth factor I receptor (IGF-1R), and IGF binding protein 3 (IGFBP3) were quantitated using Western blot. Plasma cortisol levels were higher in both NR and OF fetuses, whereas plasma IGF-1 levels were lower and higher in NR and OF fetuses. Fetal weights were reduced by 29.9% in NR ewes and were increased by 22.2% in fetuses from OF ewes compared to control group. Nutrient restriction did not affect fetal heart or ventricular weights, whereas overfeeding increased heart and ventricular weights. Protein expression of CNTFRalpha in fetal ventricular tissue was reduced in OF group, whereas STAT3 and phosphorylated STAT3 levels were reduced in both NR and OF groups. Expression of IGF-1R and IGFBP3 was unaffected in either NR or OF group. These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role.  (+info)

Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth. (3/16)

Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF) have met with limited success. The variability of results obtained with CNTF may, in part, reflect the fact that some of the biological actions of the cytokine are mediated by a complex formed between CNTF and its specific receptor, CNTFRalpha, which exists in both membrane-bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF complexed with soluble CNTFRalpha (hereafter termed "Complex") on neuronal survival and growth. Although CNTF alone produced limited effects, Complex protected against glutamate-mediated excitotoxicity via gap junction-dependent and -independent mechanisms. Further examination revealed that only Complex promoted neurite outgrowth. Differential gene expression analysis revealed that, compared with CNTF alone, Complex differentially regulates several neuroprotective and neurotrophic genes. Collectively, these findings indicate that CNTF exerts more robust effects on neuronal survival and growth when applied in combination with its soluble receptor.  (+info)

Neuroinflammation facilitates LIF entry into brain: role of TNF. (4/16)

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A putative physiological role of hypothalamic CNTF in the control of energy homeostasis. (5/16)

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CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons. (6/16)

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Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation. (7/16)

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Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia. (8/16)

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Cardiotrophin-like cytokine (CLC), also known as novel neurotrophin-1 (NNT-1) and B cell stimulating factor (BSF-3), is a member of the IL-6 family of cytokines (1, 2). CLC associates with the secreted soluble cytokine-like factor 1 (CLF-1), a member of the cytokine type I receptor family, to form the heteromeric composite cytokine CLF-1/CLC (3, 5). CLC can also form an alternate composite cytokine with soluble ciliary neurotrophic factor receptor alpha (CNTF R alpha ) (4). Co-expression of CLC with either CLF-1 or CNTF R alpha is required for the formation of the composite cytokines and for CLC secretion (3-5). CLF-1/CLC binds to the membrane-associated CNTF R alpha to initiate the heterodimerization between gp130 and leukemia inhibitory factor receptor (LIFR) and stimulate the PI 3-kinase and the MAP kinase activity. The CLF-1/CLC complex displays activities only on those cells expressing the functional tripartite receptor complex (5). Mouse CLF-1 is a 425 amino acid (aa) protein that contains ...
Purpose: Cornea consists of anatomically distinct three layers, corneal epithelium (CEp), corneal stroma (CS), corneal endothelium (CEn), that have different developmental lineages and molecular functions. To reveal their transcriptional program, we performed spatial gene expression analysis of human cornea using next generation sequencer.. Methods: 100 ng of total RNA was extracted from the macroscopically dissected tissue fractions; CEp, CS, CEn, limbal epithelium (LEp) and conjunctiva (Cj) of the human donor corneoscleral tissue. For each sample, approximately 150 million of 100-bp, paired-end reads were sequenced (HiSeq2000, Illumina) and mapped against transcriptome database using BWA aligner. Quantity of 86,817 transcripts was corrected by gene/exon length (RPKM/FPKM), and then compared using regression analysis.. Results: 24,601 Transcript (28.3%) were expressed in common with all cell fractions. Global comparison of each spatial transcriptome showed that CS shows the closest pattern ...
Electric London cab gets the full VIP treatment from Clive Sutton with limo-levels of luxury goodness for just $150,000 extra.
Drake is reminding the world why he deserves the VIP treatment. Days after being negged from the NBA Finals after party, the Canadian Young Money ...
THREE officials of the New Bilibid Prisons (NBP) and seven others are facing administrative charges for the alleged Very Important Person (VIP) treatment of convicted drug lord and Sigue Sigue Sputnik gang commander Ricardo Camata alias Chacha.. In a resolution signed by Secretary Leila de Lima, the head of the Department of Justice (DOJ) ordered the filing of charges against NBP superintendent Fajardo Lansangan, hospital head Dr. Gloria Achazo-Garcia, escort unit head Prison Supt. Gabriel Magan and medical specialist Dr. Ma. Cecilia Villanueva.. De Lima approved the findings of a fact-finding committee led by Undersecretary Francisco Baraan 3rd that prison guards Aldrid Garino, Antonio Bangoy, Eugenio Sabado, Edgardo Gamboa, Ernesto Calla and Herald Duran were liable for Camatas unauthorized confinement in a private hospital last June.. Charges of grave misconduct, gross neglect of duty and conduct prejudicial to the best interest of the service are expected to be filed against the ...
Principal Investigator:SUDA Toshihiro, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:内分泌・代謝学
Gene Hackman spent the night at the Florida hospital where he was treated for injuries he received in a car vs. bike accident Friday ... but TMZ has…
This wasnt the first time she had been in an Academy City, Myunfa Rufa thought as she stood beside the leader. No Academy City would be very wealthy. Most of its income would have been spent sustaining the livelihood of students and maintenance of facilities. As such, the Salinvan Guidance Mercenary Gang that Myunfa was in usually wouldnt be given VIP treatment. Though she didnt have a map, she knew around an Academy City would be strong Military Artists or another city, which explained the low probability of filth monsters attacking Academy Cities. One probably wouldnt know this truth if one only spent his entire life in one city, but someone had planned the locations of different Regios. (I never thought of that before I entered the Mercenary Gang.) Even so, the Mercenary Gang would sometimes visit Academy Cities not to work as hired mercenaries to fight, but to work as teachers. To allow student Military Artists to taste the atmosphere of a real fight - probably just a taste of what was ...
CILIARY NEUROTROPHIC FACTOR VARIANTS - Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue ...
Research proven, purified rabbit polyclonal GDNF Receptor Alpha 4/GFRA 4 antibody (Glial cell line-derived neurotrophic factor receptor alpha 3). Important marker embyogensis of kidneys, CNS and ENS and survival of central nervous system and peripheral neurons. Excellent for for immunohistochemistry, immunocytochemistry, western blotting, ELISA and related applications. IHC image available.
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.: Obesity plays a central role i
The relationship between ciliary neurotrophic factor CNTF genotype and motor unit physiology: preliminary studies. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Leptin, a permissive hormonal regulator of fertility, provides information about the bodys energy reserves to the hypothalamic gonadotrophin-releasing hormone (GnRH) neuronal system that drives reproduction. Leptin does not directly act on GnRH neurones, and the neuronal pathways that it uses remai …
GET YOUR MARQUETTE ON! Are you a Marquette fanatic? Interested in a chance to be flown to Milwaukee for a mens basketball home game against Syracuse? And receive VIP treatment? And be recognized on the court? And even have your own noggin? This years National Marquette Day -- set for January 29, 2011 against Syracuse -- will once again feature a Get Your Marquette On contest, challenging all Marquette fans to submit photos of themselves showing off their Marquette pride. Photo submissions ...
Complete information for CNTF gene (Protein Coding), Ciliary Neurotrophic Factor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Majru Olej kawowy / olej z ziaren kawy / Natural organic coffee oil is obtained by cold pressing roasted coffee beans. Thanks to this production process, it retains all valuable properties and a beautiful, coffee aroma. The oil contains caffeine, phytosterols, unsaturated fatty acids and vitamin E. It is used on the skin mainly for firming and smoothing the skin.
L~..Lary IUeurotroph~cPactor: Pharmacokrnetics m-d Acute-Phase Response in Rat Falk Dittrich, Hans Thoenen, and Michael Sendtnet Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circulation by the liver. No accumulation of radioactivity was detectable in nerve tissue or skeletal muscle after intravenous injection of 0.1 pg and 0.5 pg of CNTF. Radioactive degradation products accumulate in the skin. Liver cells express specific binding proteins for CNTF, and the incorporation and degradation of intravenously injected CNTF by the liver may occur after association of CNTF with the soluble CNTF receptor cu in the circulation. Probably a9 a consequence of its ...
A postdoctoral position is available in my laboratory in the areas of neurotrophic factor receptors, signal transduction and terminal differentiation of neural cells lines. Our studies include the structure of receptors, the roles of individual signal transduction pathways and the connection between neuronal differentiation and cell proliferation. My laboratory is located at the Worcester Foundation which offers a pleasant, relaxed atmosphere in a pretty suburban town near Boston. We are particularly eager to recruit a recent Ph.D. who would be eligible for a Neuroscience Training Grant recently awarded to the Worcester Foundation (American citizenship or Permanent Resident). The starting time is flexible. Some recent publications from our laboratory include: Timm et al. 1994. Circular dichroism studies of the interaction between four neurotrophins and the extracellular domain of the low affinity neurotrophin receptor. Protein Sci. 3, 451-458. Loy et al. 1994. Immunocytochemical localization of ...
This study examined the mechanisms underlying the long term functional outcome after bone marrow derived multipotent progenitor cell (MPC) transplantation in a porcine model of postinfarction Left Ventricular (LV) remodeling. Myocardial infarction (MI) was created by ligating the distal left anterior descending coronary artery (LAD). Intramyocardial injection of 50 million lacZ labeled MPC was performed in the periscar region (Cell, n=7) with 5 equal injections immediately after MI, while in control animals (CONT, n=7) saline was injected. Outcome was assessed with MRI and P-31 MRS. Engraftment was studied on histology and gene chip (Affymetrix) array analysis was used to study differential expression of genes in the two groups at 4 months. MPC treatment resulted in improvement of ejection fraction as early as 10 days after MI (32.2±9.5 vs. 43.4±5.1 in CONT and Cell respectively, p ,0.05). This improvement was seen each month and persisted up to 4 months (35.7±6.2 vs. 51.2±4.8 in CONT and ...
Description: Human CNTF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant CNTF in a sandwich ELISA format within the range of 47-3,000 pg/mL. Using the ELISA protocol described below, this kit provides sufficient reagents to assay CNTF in approximately 1,000 ELISA plate wells ...
Dear Mummy, youve been with Specsavers for over 10 years and have always loved their customer service, but recently they have gone above and beyond in your books. Little folk, like me, are now getting the VIP treatment from this high street optician in the form of dedicated kids clinics. Anything that makes me happy and…
AGEs have been shown to accumulate in diabetic and ageing organs, including ocular tissues (cornea, lens,vitreous, and retina). Accumulation of AGEs in ECM was shown to elicit several changes of ECM including decreased solubility, decreased susceptibility to enzymes, and changes in such properties as thermal stability, mechanical strength, and stiffness. These changes in the physicochemical properties of ECM are believed to contribute, in part, to the development of age related changes and diabetic complications, including cardiovascular disease, retinopathy, nephropathy, indurated skin and joint stiffness. Albonet al reported a linear age related increase of pentocidine, an advanced glycation end product, in lamina cribrosa. Accumulation of AGEs in ECM of optic nerve heads in the elderly may decrease elasticity of lamina cribrosa and compromise the ability of cribriform plates to bear the strain caused by elevated intraocular pressure. The results of the current study showed that accumulation ...
The Patch (Ph) mutation in mice is a deletion of the gene encoding the platelet-derived growth factor receptor alpha subunit (PDGFR alpha). Patch is a recessive lethal recognized in heterozygotes by its effect on the pattern of neural crest-derived pigment cells, and in homozygous mutant embryos by visible defects in craniofacial structures. Since both pigment cells and craniofacial structures are derived from the neural crest, we have examined the differentiation of other crest cell-derived structures in Ph/Ph mutants to assess which crest cell populations are adversely affected by this mutation. Defects were found in many structures populated by non-neuronal derivatives of cranial crest cells including the thymus, the outflow tract of the heart, cornea, and teeth. In contrast, crest-derived neurons in both the head and trunk appeared normal. The expression pattern of PDGFR alpha mRNA was determined in normal embryos and was compared with the defects present in Ph/Ph embryos. PDGFR alpha mRNA ...
A recombinant version of human CNTF (rhCNTF), trade name Axokine, is a modified version with a 15 amino acid truncation of the C-terminus and two amino acid substitutions. It is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability properties.[6] Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. It was tested in the 1990s as a treatment for amyotrophic lateral sclerosis. It did not improve muscle control as much as expected, but trial participants did report a loss of appetite. Phase III clinical trials for the drug against obesity were conducted in 2003 by Axokines maker, Regeneron, demonstrating a small positive effect in some patients, but the drug was not commercialized. A major problem with the treatment was that in nearly 70% of the subjects tested, antibodies against Axokine were produced after approximately three months of treatment.[7] In the minority of subjects who did not develop the antibodies, weight loss ...
The views presented here are those of the author and are not to be construed as official or reflecting the views of the Uniformed Services University of the Health Sciences, the Department of Defense or the U.S. Government ...
After hearing arguments daylong by the defence and prosecution in the infamous Jammu and Kashmir sex scandal, the District and Sessions Judge, Mr BS Mehndiratta, today fixed October 9 for pronouncing orders on the bail pleas of 13 accused in the case. However, arguments for framing of charges were not held. Of the total 14 accused in the case, one Iqbal Khandey, an IAS officer, is out on interim bail.. During the course of proceedings, the judge adjourned the case for an hour in the afternoon. Amidst heavy security arrangements outside, the accused were allowed to meet their relatives inside the courtroom during adjournment in the light of the alleged controversy over the Chandigarh Police giving them VIP treatment in the Sector 17 police station. After the arguments ended, the accused were whisked away into a bus before being escorted to the Burail Jail. For the second consecutive time, the District and Sessions Judge did not allow the media in the court. However, no written orders were passed ...
TY - JOUR. T1 - Slitlamp, Specular, and Light Microscopic Findings of Human Donor Corneas after Laser-assisted in Situ Keratomileusis. AU - Mootha, V. Vinod. AU - Dawson, Dan. AU - Kumar, Amit. AU - Gleiser, Joel. AU - Qualls, Clifford. AU - Albert, Daniel M.. PY - 2004/5. Y1 - 2004/5. N2 - Objective: To examine slitlamp, specular, and light microscopic features of human donor corneas known to have undergone laser-assisted in situ keratomileusis (LASIK). Methods: Twenty-six donor corneas known to have undergone LASIK prospectively underwent slitlamp examination with particular attention to the presence of a flap edge, as well as specular microscopy with particular attention to the presence of highly reflective particles in the stroma corresponding to the LASIK interface. Central endothelial cell density and pachymetery were obtained. They were compared with 26 control donor corneas without LASIK. Eleven LASIK donor corneas were processed for histology. Twenty-six donor corneas with no known ...
TY - JOUR. T1 - Localisation of connective tissue and inhibition of autofluorescence in the human optic nerve and nerve head using a modified picrosirius red technique and confocal microscopy. AU - Brotchie, D. AU - Birch, M. AU - Roberts, N. AU - Howard, Vyvyan. AU - Smith, VA. AU - Grierson, I. PY - 1999/2. Y1 - 1999/2. M3 - Article. VL - 87. SP - 77. EP - 85. JO - Journal of Neuroscience Methods. JF - Journal of Neuroscience Methods. SN - 0165-0270. IS - 1. ER - ...
Animals and genotyping. LIFR +/− mice generated on the B6,129/J genetic background and C57BL6 STOCK (for expanding theLIFR +/− mice) were obtained from The Jackson Laboratory (Bar Harbor, ME). Mice were then bred to allow for the generation of homozygote, heterozygote, and wild-type littermates (Koblar et al., 1998). The genotyping of mice carryingLIFR mutations was performed as described previously (Ware et al., 1995). CD-1 mice stocks were maintained in the University of Calgary Bioscience Animal Resources Center.. Neural stem cell culture and growth factors. Generation and differentiation of spheres from embryonic and adult forebrain were performed as described previously with minor modifications (Reynolds and Weiss, 1992; Reynolds et al., 1992). Briefly, striato-pallidum complexes were removed from mouse embryos at E14 and collected into PBS containing 0.6% glucose, penicillin (50 U/ml), and streptomycin (50 U/ml; both from Life Technologies, Gaithersburg, MD) and then transferred into ...
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CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of…
Background: Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this phenomenon remains unclear. ADs act as monoamine reuptake inhibitors and after prolonged treatments regulate brain bdnf mRNA levels indicating that monoamine-BDNF signaling regulate AD-induced TrkB activation in vivo. However, recent findings demonstrate that Trk receptors can be transactivated independently of their neurotrophin ligands. Methodology: In this study we examined the role of BDNF, TrkB kinase activity and monoamine reuptake in the AD-induced TrkB activation in vivo and in vitro by employing several transgenic mouse models, cultured neurons and TrkB-expressing cell lines. Principal Findings: Using a chemical-genetic TrkB(F616A) mutant and TrkB overexpressing mice, we demonstrate that ADs specifically activate both the maturely and immaturely glycosylated forms of TrkB receptors in the brain in a TrkB kinase ...
3DBT corneas are comparable to human donor corneas 3DBT corneas are made from human cells, without artificial materials or scaffolds They have the same physical characteristics as the human corneal stroma They can be seen as a direct replacement to donor tissue for anterior keratoplasty
Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor, and the mechanisms by which CNTF expression could be increased in the brain are poorly understood. Acetylsalicylic acid (aspirin) is one of the most widely used analgesics. Interestingly, aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. Aspirin induced the activation of protein kinase A (PKA) but not protein kinase C (PKC). H-89, an inhibitor of PKA, abrogated aspirin-induced expression of CNTF ...
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Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage ones masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were randomly divided into five experimental groups and one control group (6 rats per group). Animals in the experimental group were cemented modified crowns on their mandibular first molars to artificially induce occlusal trauma in 1, 3, 7, 14, and 28 days. Control group was sham-treated with forced mouth-opening for about 5 min, while no crowns were placed. After 28 days of treatment, all rats were euthanized and their masseter muscle was collected. Through immunofluorescence and real-time quantitative PCR, the expression of desmin, CNTF, and CNTFRα was investigated in rat masseter muscle. The microstructure of ...
The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.. With the intention to gain knowledge about systems that can be used to decrease RGC death after ONT, we have studied growth factor receptors belonging to the tyrosine kinase family of receptors (RTK), known to mediate important cell survival signals. We found that the RTK Ret and its coreceptor GFRα1 were expressed by RGCs, and to test the above-mentioned hypothesis, we intraocularly administered glial cell-line derived factor, which activates a Ret-GFRα1 complex, and found transiently mediated RGC survival after ONT.. To identify new, potential neurotrophic factor receptors expressed by RGCs, with the aim to improve RGC ...
Astrocytes are activated by ciliary neurotrophic factor (CNTF) in vivo and in vitro, however, the consequences on the L-type calcium channel (LCC) of neurons are still poorly understood. Therefore, in the present study, whole-cell patch clamp, western-blot and RT-PCR assay were performed to evaluate the effects of CNTF-treated astrocyte conditioned medium (CNTF-ACM) on LCC current (I(Ca)-L) and the expression of Cav1.2 and Cav1.3 in Sprague-Dawley rat cortical neurons. The results revealed that CNTF-ACM enhanced the amplitude of Ica-L and the expression of Cav1.3 significantly, but had no effects on Cav1.2 expression. We also found an increase in the concentration of fibroblast growth factor-2 (FGF-2) in CNTF-ACM by ELISA assay. Taken together, these findings indicate that CNTF induces the release of factors, including FGF-2, from astrocytes, thereby potentiating the activity of LCC in cortical neurons.. ...
Its a homecoming for Fodder scam convict and former Bihar chief minister Lalu Prasad. After being convicted in fodder scam Lalu on Saturday put in the same upper division cell where he stayed after the 2013 conviction in Ranchis Birsa Munda Jail, highly placed sources in the jail informed.. In the upper division cell, he will be entitled to avail one mosquito net, one newspaper to read every day, and a television set apart from the usual cell bed. Sources said that he can have access to home-cooked food in the jail and also prepare food for himself. The former railway minister had undergone a heart surgery in 2014 and has several restrictions in his diet.. The RJD chief and former Bihar chief minister will get VIP treatment in the prison. Other jail inmates will not be allowed to meet him during his stint here, jail officials said.. Rashtriya Janata Dal (RJD) leaders, including state party president and former minister Annapurna Devi accompanied Lalu in separate vehicles up to the jails main ...
Verizon Wireless announced the winner of its KCON Flyaway Sweepstakes last Friday, Oct. 5. Nancy Lee and three of her friends will be flying to Irvine, Calif. to experience KCON, the first convention of Korean culture in North America. As the grand prize winner, Lee and her friends will receive a free flight, hotel accommodations, dinner with K-pop group NUEST, and other VIP treatment at the event, which runs all day on Oct. 13.. KCON is one of the first Korean culture events not to focus solely on Korean pop music, also known as K-pop. In addition to musical performances by groups 4Minute, VIXX, B.A.P. Exo-M, G.NA and NUEST, there will also be several panels throughout the day, covering things from fashion, to online gaming, to speed dating.. Its going to be a whirlwind of fun, Lee said. Im going to live it up as much as I can.. Lee was chosen randomly from among thousands of entries from California and Washington state. (end). ...
To identify and characterize the Retinal stem/progenitor properties of Human Iris Pigment Epithelial (IPE) cells and Ciliary Epithelial (CE) cells in vitro. In this project we are working on the isolation and characterization of the retinal stem cells from the Iris and ciliary pigment epithelial cells invitro, which would facilitate us to find an alternative therapy for the treatment of retinal degenerative disorders. ...
Fetal alcohol exposure (FAE) causes various neurodevelopmental deficits in offspring, including reduced expression of the stress regulatory proopiomelanocortin (Pomc) gene and an elevated stress response for multiple generations via the male germline. Male germline-specific effects of FAE on the Pomc gene raises the question if the sex-determining region Y (SRY) may have a role in regulating Pomc gene expression. Using a transgenerational model of FAE in Fischer 344 rats, we determined the role of SRY in the regulation of the Pomc gene. FAEs, like on the Pomc gene, reduced Sry gene expression in sperm and the mediobasal hypothalamus (MBH) in male adult offspring. Fetal alcohol-induced inhibition of Sry gene expression was associated with increased Sry promoter DNA methylation. Additionally, fetal alcohol effects on the Sry gene persisted for three generations in the male germline but not in the female germline. Sry gene knockdown reduced the Pomc gene expression. Sry recruitment onto the Pomc promoter
Results: The athlete group showed an allelic distribution of ACTN3 (R/R:64%, R/X:16%, X/X:20%) and CNTF (G/G:72%, G/A:26%, A/A:2%), significantly imbalanced towards alleles R/R and G/G, respectively, compared to controls (ACTN3=R/R:40% R/X:22% X/X:38% and CNTF=G/G:52%, G/A:24%, A/A:24%) (p=0.0024 and p=0.0001, respectively). Only the ACTN3 577X/X polymorphism showed a significant association with the anaerobic threshold of athletes (F-ratio= 4.037; p=0.025). Factorial ANOVA demonstrated a non significant interaction between favourable allelic patterns of ACTN3 and CNTF genes on aerobic performance in the athlete group ...
title: Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia, doi: 10.1016/j.cellsig.2014.11.003, category: Article
The purpose of this study is to compare the success of storing a donor cornea in Optisol GS, the current standard vs. storing the donor cornea in Life4°C, a newer solution. The donor cornea to be used for EK will be provided by an eye bank and will have been stored in either an Optisol GS solution or a Life 4°C solution. At 6 months, the doctors will determine whether there are any comparable differences in cell loss and graft clarity between the two donor corneas ...
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified. GRCh38: Ensembl release 89: ENSG00000137070 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: IL11RA interleukin 11 receptor, alpha. Chérel M, Sorel M, Lebeau B, et al. (1995). Molecular cloning of two isoforms of a ...
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Patient Presentation A 53-day-old former 32 week premature female came to clinic for her health supervision visit after discharge from the neonatal intensive care unit. She had been discharged 3 days ago and her parents reported that overall they were doing well. She had had a couple of spit-up episodes after feedings that were random…
Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi:10.1126/science. ...
This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ...
"The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor (LIF) is a polyfunctional cytokine ... including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ...
This family includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor ( ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31RA binds IL-31 through ...
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor. Cluster of ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein ...
1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 ... ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through ... "The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta ... Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. IL-10 is a ...
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Ciliary neurotrophic factor ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica Acta Helvetiae. 74 (2-3): 265-72. doi: ...
2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional ... It induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... 2006). "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold- ...
... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045 ... "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". ...
... ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several other proteins which have structural ... It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common ... "Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ...
Ciliary neurotrophic factor family *Ciliary neurotrophic factor (CNTF). *Leukemia inhibitory factor (LIF) ... The alpha granules in blood platelets contain growth factors PDGF, IGF-1, EGF, and TGF-β which begin healing of wounds by ... Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells. ... Migration-stimulating factor (MSF). *Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein ...
... brain-derived neurotrophic factor MeSH D23.348.479.875.212 - ciliary neurotrophic factor MeSH D23.348.479.875.325 - glia ... receptors, tumor necrosis factor, type i MeSH D23.050.301.264.035.912 - receptors, tumor necrosis factor, type ii MeSH D23.050. ... transforming growth factor alpha MeSH D23.348.479.992.720 - transforming growth factor beta MeSH D23.348.479.996 - wnt proteins ... beta subunit, human MeSH D23.101.840.375 - hormones, ectopic MeSH D23.101.840.400 - ki-67 antigen MeSH D23.101.840.500 - ...
... receptor, ciliary neurotrophic factor MeSH D12.776.543.750.750.400.550.500 - receptor, nerve growth factor MeSH D12.776.543.750 ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... receptor, platelet-derived growth factor alpha MeSH D12.776.543.750.060.625.400 - receptor, platelet-derived growth factor beta ... receptors, nerve growth factor MeSH D12.776.543.750.750.400.550.124 - glial cell line-derived neurotrophic factor receptors ...
... mechanisms that modulate cellular responses to these factors remain unclear. Six-transmembrane glycerophosphodiester ... Ciliary Neurotrophic Factor / metabolism * Ciliary Neurotrophic Factor Receptor alpha Subunit / metabolism* * Cytokines / ... GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα ... the ligand-binding component of the CNTF-receptor multiprotein complex, which can function as a soluble factor to activate CNTF ...
Ciliary neurotrophic factor receptor subunit alpha antibody. *CNTF Receptor alpha antibody. *CNTF receptor subunit alpha ... Ciliary neurotrophic factor receptor alpha antibody. *Ciliary neurotrophic factor receptor antibody. * ... Belongs to the type I cytokine receptor family. Type 3 subfamily.. Contains 2 fibronectin type-III domains.. Contains 1 Ig-like ... appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor ...
Ciliary neurotrophic factor receptor subunit alpha antibody. *CNTF Receptor alpha antibody. *CNTF receptor subunit alpha ... Ciliary neurotrophic factor receptor alpha antibody. *Ciliary neurotrophic factor receptor antibody. * ... Perugini J et al. Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes. Front Endocrinol (Lausanne) 10:768 ( ... Belongs to the type I cytokine receptor family. Type 3 subfamily.. Contains 2 fibronectin type-III domains.. Contains 1 Ig-like ...
Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi:10.1126/science. ...
Ciliary neurotrophic factor receptor subunit alpha Show on y-axis - References (HTP + LTP). References (LTP). References (HTP) ...
HUMAN 118946 Ciliary neurotrophic factor receptor subunit alpha precursor (CNTF receptor subunit alpha) (CNTFR-alpha) CNTLN ... HUMAN 600939 Interleukin-11 receptor subunit alpha precursor (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R- ... Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) ( ... SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF ...
Ciliary neurotrophic factor receptor subunit alpha is a protein in humans that is encoded by CNTFR gene. Binds to CNTF. The ... Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Chicken Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Mouse Ciliary neurotrophic factor receptor subunit alpha(Cntfr). Yeast. E.coli. Baculovirus. Mammalian cell. ...
Leukemia Inhibitory Factor Receptor alpha Subunit. *Lifr protein, mouse. *Membrane Glycoproteins. *Receptor, Ciliary ... The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ...
Ciliary neurotrophic factor receptor subunit alpha P26992 Coagulation Factor V P12259 Fetuin-B Q9UGM5 ...
Ciliary neurotrophic factor receptor subunit alpha; Discoidin, CUB and LCCL domain-containing protein 2; Ephrin-B2; Leucine- ... Ciliary neurotrophic factor receptor subunit alpha (CNTFR); Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2); ... Complement factor H-related 1. CNTFR:. Ciliary neurotrophic factor receptor subunit alpha ... Either way, IR is potentially a modifiable risk factor for AD; however, it is still unclear exactly how and at what stage IR ...
This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ...
LIF Receptor Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Ciliary neurotrophic factor receptor alpha subunit. *307. Human Protein Atlas (HPA):. *Cancer-related genes ... to ciliary neurotrophic factor receptor activity. IDA. 12643274. GO:0004923. contributes_to leukemia inhibitory factor receptor ... contributes_to oncostatin-M receptor activity. IDA. 8999038. GO:0005127. ciliary neurotrophic factor receptor binding. IPI. ...
Ciliary neurotrophic factor,CNTF]] ** [[Cardiotrophin 1,CTF1]] , group6 = [[IL12 family]]/[[Interleukin 12 receptor, beta 1 ... Tumor necrosis factors,TNF]] , list2 = * [[Tumor necrosis factor alpha,TNFA]] * [[Lymphotoxin]] ** [[Lymphotoxin alpha,TNFB/LTA ... Type I cytokine receptor,Type I]],br>(grouped by,br>receptor,br>subunit) , list1 = {{Navbox,subgroup , group1 = [[Common gamma ... Stem cell factor,KITLG]] ** [[Colony-stimulating factor]] * [[Osteopontin,SPP1]] * [[Macrophage migration inhibitory factor,MIF ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... Interleukin-6 Receptor alpha Subunit. *Interleukin-7 Receptor alpha Subunit. *Leukemia Inhibitory Factor Receptor alpha Subunit ... They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. ... Interleukin-3 Receptor alpha Subunit. *Interleukin-4 Receptor alpha Subunit. *Interleukin-5 Receptor alpha Subunit ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... It binds preferentially to ephA receptors (EPH FAMILY RECEPTORS) with the exception of the EPHA1 RECEPTOR. ...
... including the ciliary neurotrophic factor, growth hormone and prolactin. ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that ... LIFR; Interferon α Receptor β Chain; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; ... FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor; cytokine receptor-beta ...
Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]. *Leukemia Inhibitory Factor Receptor alpha Subunit [ ... Leukemia Inhibitory Factor Receptor alpha Subunit*Leukemia Inhibitory Factor Receptor alpha Subunit ... Receptors, OSM-LIF [D12.776.543.750.705.852.500]. *Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852. ... Receptors, OSM-LIF [D12.776.543.750.705.852.555.800]. *Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750. ...
Compare and order CNTF Receptor alpha ELISA试剂盒. View citations, images, detection ranges, sensitivity, prices and more. ... CNTFR-alpha , ciliary neurotrophic factor receptor subunit alpha , CNTFR alpha , ciliary neurotrophic factor receptor alpha , ... growth-promoting activity receptor subunit alpha , ciliary neurotrophic factor receptor , ciliary neurotrophic factor receptor ... ciliary neurotrophic factor receptor subunit alpha preproprotein , GPA receptor subunit alpha , GPAR-alpha , growth promoting ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... Interleukin-3 Receptor alpha Subunit. *Interleukin-4 Receptor alpha Subunit. *Interleukin-5 Receptor alpha Subunit ... Leukemia Inhibitory Factor Receptor alpha Subunit. *Low Density Lipoprotein Receptor-Related Protein-1 ... Interleukin-18 Receptor alpha Subunit. *Interleukin-18 Receptor beta Subunit. *Interleukin-2 Receptor alpha Subunit ...
Ciliary neurotrophic factor receptor subunit alpha,CNTF receptor subunit alpha,CNTFR,CNTFR-alpha,Gallus gallus,GPA receptor ... CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha ... CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha ... ELISA IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse, ...
ciliary neurotrophic factor receptor complex Source: Ensembl. *external side of plasma membrane Source: Ensembl ... Oncostatin-M receptor subunit alpha) (CD antigen CD130) ... Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta ... Interleukin-6 receptor subunit betaImported. ,p>Information which has been imported from another database using automatic ... tr,F1LPK1,F1LPK1_RAT Interleukin-6 receptor subunit beta OS=Rattus norvegicus OX=10116 GN=Il6st PE=1 SV=3 ...
BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.. Receptor, Nerve Growth Factor ... It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity. ... Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes ... A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4. ...
Membrane-bound transcription factor site-1 protease (S1P) is an emerging clinical target due to its roles in lipogenesis, ... The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the ... Leukemia Inhibitory Factor Receptor Alpha Subunit. A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the ... Nuclear Receptor Coactivator 2. A transcription factor that partners with ligand bound GLUCOCORTICOID RECEPTORS and ESTROGEN ...
688622 Il31ra; interleukin-31 receptor subunit alpha precursor 313173 Cntfr; ciliary neurotrophic factor receptor subunit alpha ... interleukin 27 receptor alpha K22630 IL31RA; interleukin 31 receptor subunit alpha K05059 CNTFR; ciliary neurotrophic factor ... 25084 Il4r; interleukin-4 receptor subunit alpha precursor 294797 Il7r; interleukin-7 receptor subunit alpha precursor 24500 ... 100360218 interleukin-13 receptor subunit alpha-1 171060 Il13ra2; interleukin-13 receptor subunit alpha-2 precursor 24336 Epor ...
... leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding ... Oncostatin-M receptor subunit alpha ... cytokine receptor activity ciliary neurotrophic factor receptor ... ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part ... oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6ST; ...
ciliary neurotrophic factor binding;ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6receptor ... Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2;Membrane glycoprotein 80; interleukin 6 receptor; ... interleukin 6 receptoralpha subunit.. Gene ID:. 3570. mRNA Refseq:. NM_000565. Protein Refseq:. NP_000556. ... IL6R interleukin 6 receptor [ Homosapiens ]. Synonyms:. IL6R; interleukin 6receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; ...
The expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) was investigated in the developing chick dorsal root ... of heteromeric receptor complexes and depend on the presence of the ligand-binding receptor subunits CNTFR alpha and GPAR alpha ... Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during ... Growth promoting activity (GPA) is a chick growth factor with low homology to mammalian ciliary neurotrophic factor (CNTF) (47 ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Cytokine Receptor gp130. *Leukemia Inhibitory Factor Receptor alpha ... Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]. *Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400. ... Receptors, Oncostatin M, Type II [D12.776.543.750.705.852.555.600]. *Cytokine Receptor gp130 [D12.776.543.750.705.852.555.600. ... A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS. ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant ... Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. Cancer Res. 2015 May ...
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. ... Interleukin-3 Receptor alpha Subunit. *Interleukin-4 Receptor alpha Subunit. *Interleukin-5 Receptor alpha Subunit ... Leukemia Inhibitory Factor Receptor alpha Subunit. *Low Density Lipoprotein Receptor-Related Protein-1 ...
  • GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function as a soluble factor to activate CNTF signaling. (nih.gov)
  • Ciliary neurotrophic factor (CNTF) is involved in the survival of a number of different neural cell types, including motor neurons. (nih.gov)
  • CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha component (CNTFR). (nih.gov)
  • The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). (thermofisher.com)
  • CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. (acris-antibodies.com)
  • CNTF effects are mediated by a tripartite receptor complex consisting of two sigl-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular sigling moiety. (acris-antibodies.com)
  • It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRa).CNTF binds to CNTFRa, the latter associates with gp130 which recruits LIFR. (acris-antibodies.com)
  • Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRa and activates a similar sigling pathway to that of CNTF. (acris-antibodies.com)
  • Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral hemorrhage in rats. (acris-antibodies.com)
  • BACKGROUND: The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor alpha component (CNTFR). (inserm.fr)
  • Recently, we have identified two new ligands for the CNTF receptor complex. (inserm.fr)
  • RESULTS: Here we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. (inserm.fr)
  • CONCLUSION: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development. (inserm.fr)
  • Ciliary neurotrophic factor (CNTF) is well known as a growth/survival factor of neuronal tissue. (bvsalud.org)
  • We investigated the expression of CNTF and its specific receptor alpha (CNTFRalpha) in a unilateral ureteral obstruction (UUO) model. (bvsalud.org)
  • Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. (semanticscholar.org)
  • Signaling of human ciliary neurotrophic factor (CNTF) revisited. (wikidoc.org)
  • Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPP⁺-lesioned rats via ciliary neurotrophic factor (CNTF). (bvsalud.org)
  • CNTF receptor alpha neutralizing antibody (CNTFRαNAb) was nigral injected to evaluate the role of CNTF endogenously produced by astrocyte through TRPV1 activation on DA neurons. (bvsalud.org)
  • One class of neurotrophic factor acts through receptor complexes involving the low-affinity leukaemia inhibitory factor receptor subunit (LIF-R). Members of this family of cytokines, such as ciliary neurotrophic factor (CNTF) and leukaemia inhibitory factor (LIF), have profound effects on the survival and maintenance of motor neurons. (ed.ac.uk)
  • In wounded corneas, diabetes markedly delayed sensory nerve regeneration and reduced the number of infiltrating DCs, which were a major source of ciliary neurotrophic factor (CNTF) in the cornea. (jci.org)
  • Moreover, blockade of the CNTF-specific receptor CNTFRα induced sensory nerve degeneration and retarded regeneration in normal corneas. (jci.org)
  • All of these cytokines act via a bi- or tripartite receptor complex in which signaling is triggered by homodimerization (IL6) or heterodimerization with LIF-Rb/gp190 protein (IL11, LIF, OSM, and CNTF) of gp130. (receptome.org)
  • IL-6R , IL-11R , LIF-R , OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin -R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors . (chemeurope.com)
  • In these studies, members of the interleukin (IL)-6 family of cytokines including, leukemia inhibitory factor (LIF), IL-6, and ciliary neurotrophic factor (CNTF) and associated receptors, IL-6 receptor (R) α, LIFR, and gp130 were examined in the urinary bladder in control and CYP-treated rats. (frontiersin.org)
  • Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. (rndsystems.com)
  • Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. (rndsystems.com)
  • Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. (wikipedia.org)
  • Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (creative-biogene.com)
  • The activation of this protein is dependent upon the binding of cytokines to their receptors. (thermofisher.com)
  • IL6R subunit also shared by many other cytokines. (creativebiomart.net)
  • IL-31 is unique in this family of cytokines because its receptor complex does not contain gp130. (wikidoc.org)
  • In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. (kegg.jp)
  • Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. (kegg.jp)
  • These are heterodimeric cytokines composed of cardiotrophin-like cytokine (CLC) associated either with the soluble receptor subunit cytokine-like factor-1 (CLF) or the soluble form of the binding receptor itself (sCNTFR). (inserm.fr)
  • The IL-6R shares many features with other receptors of the IL-6 family of cytokines, notably the interleukin-11 receptor (IL-11R) and the ciliary neurotrophic factor receptor (CNTFR) (Garbers et al. (springer.com)
  • 2012 ). All these cytokines signal through the common β-receptor glycoprotein 130 (gp130). (springer.com)
  • Hence, a novel negative crosstalk mechanism for cytokine signalling is described, where cytokine receptor turnover is regulated in trans by pro-inflammatory cytokines and stress stimuli to coordinate the inflammatory response. (uni.lu)
  • The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. (uni.lu)
  • IL-6-type cytokines exert their action via the signal transducers gp (glycoprotein) 130, LIF receptor and OSM receptor leading to the activation of the JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen-activated protein kinase) cascades. (uni.lu)
  • Development and maintenance of the mammalian nervous system is dependent upon neurotrophic cytokines. (ed.ac.uk)
  • Spanning nearly 150 select biomarkers including important cytokines, acute phase reactants, growth factors and cancer markers, ExplorerMAP can be utilized by drug and diagnostic developers in several therapy areas including inflammation, immune response, cardiovascular, neurological, metabolic and cancer. (myriadrbm.com)
  • Molecules currently under study include receptors of the immune system involved in autoimmune disorders (T cell receptors, co-receptors, MHC, cytokines), proteins involved in host-pathogen interactions and molecular mimicry (CMV and Toxoplasma surface antigens), proteins of nervous system (peptide hormone receptors, neural guidance proteins), and membrane proteins (chemokine receptors). (stanford.edu)
  • Larsen, Hansen, Møller, Madsen, Scheller, Nielsen, Petersen: Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. (antikoerper-online.de)
  • The protein functions as a part of the cytokine receptor complex and its activation is dependent upon the binding of cytokines to their receptors. (cellsciences.com)
  • All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes. (rndsystems.com)
  • The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. (wikipedia.org)
  • Ciliary neurotrophic factor receptor subunit alpha is a protein in humans that is encoded by CNTFR gene. (cusabio.com)
  • The expressions of miR-146a and ciliary neurotrophic factor receptor (CNTFR) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in ALL and AML pediatric patients, as well as ALL (Jurkat) and AML (HL-60) cells. (bvsalud.org)
  • The activation of a naive T-Cell requires two signals: ligation of the TCR (T-Cell Receptor) with the MHC (Major Histocompatibility Complex)/peptide complex on the APC (Antigen Presenting Cell). (qiagen.com)
  • A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. (uams.edu)
  • gp130 is a subunit of several heterodimeric cell-surface receptors, including receptors for IL-6, IL-11, IL-27, Oncostatin M, and Leukemia Inhibitory Factor (LIF). (thermofisher.com)
  • Auf www.antikoerper-online.de finden Sie aktuell 338 Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper von 25 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved structural and surface character. (ox.ac.uk)
  • This receptor and its cognate ligand support the survival of neurons. (wikipedia.org)
  • Differences in receptor-ligand interactions mediate unique biological functions. (antibody-antibodies.com)
  • Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. (antibody-antibodies.com)
  • This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligand(s) is still not clearly established. (inserm.fr)
  • A model for receptor binding based on the structure of the growth hormone ligand/receptor complex requires additional, novel features to account for these data. (ox.ac.uk)
  • My laboratory studies the structural and functional basis of receptor/ligand interactions in systems which are relevant to human health and disease. (stanford.edu)
  • Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. (stanford.edu)
  • Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • This graph shows the total number of publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in UAMS Profiles by year, and whether "Leukemia Inhibitory Factor Receptor alpha Subunit" was a major or minor topic of these publications. (uams.edu)
  • Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles over the past ten years. (uams.edu)
  • vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. (thermofisher.com)
  • The IL6R complex is composed of two membrane glycoproteins: thelow affinity receptor and the signaltransducing component. (creativebiomart.net)
  • Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. (creativebiomart.net)
  • IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. (creativebiomart.net)
  • IL6R also denotes the human gene encoding this subunit. (creativebiomart.net)
  • Background: IL6R alpha(IL6RA) also known as CD126 or IL6R, is a type I cytokine receptor. (biobool.com)
  • Interleukin 6 receptor ( IL6R ) also known as CD126 ( C luster of D ifferentiation 126 ) is a type I cytokine receptor . (wikidoc.org)
  • Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). (selfdecode.com)
  • IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor alpha (IL-31RA) and the OSM receptor beta (OSMR). (biomedcentral.com)
  • This mutant still binds to the receptor subunits gp130 and OSMR. (uni.lu)
  • However, we found that the SH2 domain is structurally important for cytokine receptor binding and surface expression of the OSMR. (uni.lu)
  • Cloned and characterized an alternative signaling subunit conferring OSM-specific receptor activation.The receptor for OSM is a dimmer of OSMR-beta and gp130. (receptome.org)
  • The receptor for OSM is a dimmer of OSMR-beta and gp130. (receptome.org)
  • OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR. (antikoerper-online.de)
  • This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. (genecards.org)
  • LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. (creative-biogene.com)
  • LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. (creative-biogene.com)
  • The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. (creative-biogene.com)
  • The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor. (uams.edu)
  • The crystal structure of murine leukemia inhibitory factor. (ox.ac.uk)
  • We have determined the structure of murine leukemia inhibitory factor (LIF) by X-ray crystallography at 2.0 A resolution. (ox.ac.uk)
  • Auf www.antikoerper-online.de finden Sie aktuell 113 Leukemia Inhibitory Factor Receptor alpha (LIFR) Antikörper von 15 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Murphy, Halow, Royer, Hennebold: Leukemia Inhibitory Factor Is Necessary for Ovulation in Female Rhesus Macaques. (antikoerper-online.de)
  • The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells. (antikoerper-online.de)
  • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. (semanticscholar.org)
  • Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250 kDa each. (embl-heidelberg.de)
  • LIFR (LIF Receptor Alpha) is a Protein Coding gene. (genecards.org)
  • These results led us to speculate that the phenomenon was attributable to an interruption of the retrograde supply of glial cell line-derived neurotrophic factor (GDNF). (alliedacademies.org)
  • In the present study, we focused on glial cell line-derived neurotrophic factor (GDNF) as a possible candidate. (alliedacademies.org)
  • Glial cell line-derived neurotrophic factor (GDNF) from rats (G1401) and anti-human GDNF antibody (G8035) that can detect rat GDNF were purchased from Sigma-Aldrich Japan (Tokyo, Japan). (alliedacademies.org)
  • These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. (kegg.jp)
  • Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. (springer.com)
  • We developed a renally accumulating conjugate of a TGF-beta type-I receptor kinase inhibitor (TKI) and evaluated its efficacy in vitro and in vivo. (courtfield.tk)
  • 1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. (chemeurope.com)
  • These neurons depend on nerve growth factor (NGF) from their target areas for survival. (bioportfolio.com)
  • Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic. (bioportfolio.com)
  • The pharmacology of Nerve Growth Factor (NGF) and the discovery and development of tanezumab, a monoclonal anti-NGF antibody for the treatment of pain illustrate the complex and unpredictable nature o. (bioportfolio.com)
  • Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium. (bioportfolio.com)
  • Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. (bioportfolio.com)
  • Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. (bioportfolio.com)
  • To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy. (bioportfolio.com)
  • NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. (bioportfolio.com)
  • Nerve growth factor was significantly upregulated in surgical vs. control and in herniated vs. control discs. (biomedcentral.com)
  • Davies, A.M. (1989) in Neurotrophic Factor Bioassay Using Dissociated Neurons , Nerve Growth Factor. (rndsystems.com)
  • In addressing factors that might cause a compromised reinnervation response with aging, it is relevant to note that following surgical denervation in healthy young animals, there is a robust increase in neurotrophins, including brain-derived neurotrophic factor ( BDNF ) [ 12 ]. (biomedcentral.com)
  • The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cy. (nih.gov)
  • Cellular senescence or EGFR signaling induces interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). (springer.com)
  • 22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. (antibody-antibodies.com)
  • STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. (antibody-antibodies.com)
  • Interleukins 19, 20, and 24 signal through two distinct receptor complexes. (antibody-antibodies.com)
  • A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS. (umassmed.edu)
  • Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (antibody-antibodies.com)
  • Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. (wikidoc.org)
  • This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. (wikipedia.org)
  • This gene encodes a protein that belongs to the type I cytokine receptor family. (genecards.org)
  • Gene Ontology (GO) annotations related to this gene include growth factor binding and ciliary neurotrophic factor receptor activity . (genecards.org)
  • Sequestration of a transcription factor in a cellular membrane and releasing it on demand is an additional layer of gene regulation that is considered a rapid mode to reprogram a gene expression casca. (bioportfolio.com)
  • A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. (springer.com)
  • Consequently, inhibition of p38 or MK2, deletion of MK2 or mutation of crucial amino acids within the MK2 target site or the di-leucine internalisation motif blocks receptor depletion and restores IL-6-dependent STAT activation as well as gene induction. (uni.lu)
  • Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. (pnas.org)
  • Analyses of more degenerated vs. less degenerated discs identified significant upregulation of well-recognized pain-related genes (bradykinin receptor B1, calcitonin gene-related peptide and catechol- 0 -methyltransferase). (biomedcentral.com)
  • Immunohistochemistry was utilized to confirm the presence of calcitonin gene-related peptide, catechol-0-methyltransferase and bradykinin receptor B1 at the protein level in the human annulus. (biomedcentral.com)
  • not taken to ERBB4, SHC1 is Multiple on gene hemopexin by the paraplegia protein alpha-tocopherol of ERBB4, which is it to repair the apoptosis of GRB2 and SOS1, activating in the complex production on cysteine and perilipin of triphosphate and cycling methionine condensin( Kainulainen et al. (erik-mill.de)
  • Anastasiou V, Mikrou A, Papanastasiou AD et al (2011) The molecular identification of factor H and factor I molecules in rainbow trout provides insights into complement C3 regulation. (springer.com)
  • Ao J, Ding Y, Chen Y et al (2015) Molecular characterization and biological effects of a C-type lectin-like receptor in large yellow croaker ( Larimichthys crocea ). (springer.com)
  • It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. (acris-antibodies.com)
  • Belongs to the type I cytokine receptor family. (abcam.com)
  • Our earlier study indicated that the activation of STAT3 was essential for HN-induced neuroprotection, suggesting that the HN receptor may belong to the cytokine receptor family. (semanticscholar.org)
  • A monoclonal antibody from mouse specific for IL-6R Alpha has been precoated onto 96-well plates. (biobool.com)
  • Standards(sf21,L20-D358) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for IL-6R Alpha is added subsequently and then followed by washing with PBS or TBS buffer. (biobool.com)
  • The anti-GDNF antibody-stained cells in the facial nucleus were almost coincident with the anti-NMDA receptor 3B subunit (NR3B) antibody-positive cells, suggesting that the former were motoneurons. (alliedacademies.org)
  • The antibody against NMDA receptor 3B subunit (NR3B) (ab35677) used for identifying motoneurons was supplied by Abcam (Cambridge, UK). (alliedacademies.org)
  • Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. (wikipedia.org)
  • 1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. (wikipedia.org)
  • IL-11 responsiveness is restricted to cells that express the interleukin-11 receptor alpha-chain (IL-11Ralpha) and an additional signal-transducing subunit (gp130). (receptome.org)
  • In our previous study, we reported that the levels of m2 muscarinic acetylcholine receptor and gammaaminobutyric acid receptor α1 in motoneurons were downregulated in the axotomized adult facial nucleus. (alliedacademies.org)
  • We previously reported that adult rat facial nerve axotomy led to decreased levels of m2 muscarinic acetylcholine receptor (m2MAchR) and gamma-aminobutyric acid receptor α1 (GABA A Rα1) in living motoneurons in the ipsilateral nucleus [ 1 , 2 ]. (alliedacademies.org)
  • Both aging rat muscle and Sarco mouse muscle exhibited marked fiber-type grouping, consistent with repeating cycles of denervation and reinnervation, yet in VO muscle, rapsyn at the endplate increased and was associated with only a 10 % decline in acetylcholine receptor (AChR) intensity, whereas in Sarco mice, there was a decline in rapsyn and a 25 % decrease in AChR intensity. (biomedcentral.com)
  • Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients. (bioportfolio.com)
  • Immunohistochemical analysis revealed disruption of rod outer segments, focal loss of the RPE integrity, and an increase in expression of endothelin receptor B in Müller cells with the two highest doses of light and fundus photography. (arvojournals.org)
  • A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (lbl.gov)
  • Cytokine and receptor transcript and protein expression and distribution were determined in urinary bladder after CYP-induced cystitis using quantitative, real-time polymerase chain reaction (Q-PCR), western blotting, and immunohistochemistry. (frontiersin.org)
  • 1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. (chemeurope.com)
  • Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (antibody-antibodies.com)
  • The studies presented herein show that a broad spectrum of antimalarial drugs augmented the replication of SFV in mice, concomitant with greater tissue damage and up-regulation of mRNA levels of various inflammatory cytokine genes, including interleukin-1 receptor antagonist (IL-1Ra), II-1alpha, IL-1beta, IL-6, IL-12p40, and interferon-gamma inducing factor. (ajtmh.org)
  • The alpha subunit provides the receptor specificity. (abcam.com)
  • Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. (springer.com)