Ciliary Neurotrophic Factor Receptor alpha Subunit: A ciliary neurotrophic factor receptor subunit. It is anchored to the cell surface via GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and has specificity for binding to CILIARY NEUROTROPHIC FACTOR. It lacks signal transducing domains which are found on the other two subunits of the receptor.Receptor, Ciliary Neurotrophic Factor: Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).Ciliary Neurotrophic Factor: A neurotrophic factor that promotes the survival of various neuronal cell types and may play an important role in the injury response in the nervous system.Receptors, Nerve Growth Factor: Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.Leukemia Inhibitory Factor Receptor alpha Subunit: A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.Receptor, Platelet-Derived Growth Factor alpha: A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.Brain-Derived Neurotrophic Factor: A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)Glial Cell Line-Derived Neurotrophic Factor Receptors: A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.Nerve Growth Factors: Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.Receptor, trkB: A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; neurotrophin 4 and neurotrophin 5. It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells.

Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. (1/16)

PURPOSE: Ciliary neurotrophic factor (CNTF) promotes gene expression, cell survival and differentiation in various types of peripheral and central neurons, glia and nonneural cells. The level of CNTF rises rapidly upon injury to neural tissue, suggesting that CNTF exerts its cytoprotective effects after release from cells via mechanisms induced by cell injury. The purpose of this study was to determine if cells in the optic nerve head express CNTF and its tripartite receptor complex. METHODS: Well-established optic nerve head astrocytes (ONHA) and lamina cribrosa (LC) cell cultures were derived from normal human donors. Total RNA was reverse transcribed and polymerase chain reaction (PCR) amplified for mRNA detection. Cytoplasmic protein expression was determined by immunocytochemistry and Western blot analysis of the cellular lysates. Serum free medium was concentrated and used for detecting extracellular proteins. CNTF complexed with CNTFR-alpha was assayed by immunoprecipitation. RESULTS: Cells isolated from the human optic nerve head express CNTF and its tripartite receptor complex members (CNTFR-alpha, gp130, LIFR-beta). CONCLUSIONS: Taken together, these data suggest a possible neuroprotective role of CNTF in the optic nerve head.  (+info)

Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. (2/16)

Intrauterine nutrition status is reported to correlate with risk of cardiovascular diseases in adulthood. Either under- or overnutrition during early to mid gestation contributes to altered fetal growth and ventricular geometry. This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. Multiparous ewes were fed with 50% [nutrient-restricted (NR)], 100% (control) or 150% [overfed (OF)] of National Research Council requirements from 28 to 78 days of gestation (dG; term, 148 dG). Ewes were euthanized on Day 78, and the gravid uteri and fetuses recovered. Ventricular protein expression of CNTFRalpha, STAT3, phosphorylated STAT3, insulin-like growth factor I receptor (IGF-1R), and IGF binding protein 3 (IGFBP3) were quantitated using Western blot. Plasma cortisol levels were higher in both NR and OF fetuses, whereas plasma IGF-1 levels were lower and higher in NR and OF fetuses. Fetal weights were reduced by 29.9% in NR ewes and were increased by 22.2% in fetuses from OF ewes compared to control group. Nutrient restriction did not affect fetal heart or ventricular weights, whereas overfeeding increased heart and ventricular weights. Protein expression of CNTFRalpha in fetal ventricular tissue was reduced in OF group, whereas STAT3 and phosphorylated STAT3 levels were reduced in both NR and OF groups. Expression of IGF-1R and IGFBP3 was unaffected in either NR or OF group. These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role.  (+info)

Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth. (3/16)

Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF) have met with limited success. The variability of results obtained with CNTF may, in part, reflect the fact that some of the biological actions of the cytokine are mediated by a complex formed between CNTF and its specific receptor, CNTFRalpha, which exists in both membrane-bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF complexed with soluble CNTFRalpha (hereafter termed "Complex") on neuronal survival and growth. Although CNTF alone produced limited effects, Complex protected against glutamate-mediated excitotoxicity via gap junction-dependent and -independent mechanisms. Further examination revealed that only Complex promoted neurite outgrowth. Differential gene expression analysis revealed that, compared with CNTF alone, Complex differentially regulates several neuroprotective and neurotrophic genes. Collectively, these findings indicate that CNTF exerts more robust effects on neuronal survival and growth when applied in combination with its soluble receptor.  (+info)

Neuroinflammation facilitates LIF entry into brain: role of TNF. (4/16)

 (+info)

A putative physiological role of hypothalamic CNTF in the control of energy homeostasis. (5/16)

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CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons. (6/16)

 (+info)

Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation. (7/16)

 (+info)

Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia. (8/16)

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*Ciliary neurotrophic factor receptor

... alpha Subunit at the US National Library of Medicine Medical Subject Headings (MeSH). ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. doi:10.1126/science.1648265. PMID 1648265. Sleeman ...

*Interleukin 11 receptor alpha subunit

This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ... 2003). "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75 ...

*Interleukin 31

This family includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor ( ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31RA binds IL-31 through ...

*Leukemia inhibitory factor receptor

"The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that ... including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ...

*Interleukin-6 receptor

"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor. Cluster of ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein ...

*Tyrosine kinase 2

1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 ... ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like cytokine, and LIF, Tyk2 might also affect signaling through ... "The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta ... Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. IL-10 is a ...

*Ciliary neurotrophic factor

"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Axokine Ciliary neurotrophic ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica acta Helvetiae. 74 (2-3): 265-72. doi: ...

*CLCF1

2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional ... CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... 2006). "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold- ...

*Janus kinase 1

... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045 ... "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". ...

*List of MeSH codes (D23)

... brain-derived neurotrophic factor MeSH D23.348.479.875.212 --- ciliary neurotrophic factor MeSH D23.348.479.875.325 --- glia ... receptors, tumor necrosis factor, type i MeSH D23.101.100.110.916 --- receptors, tumor necrosis factor, type ii MeSH D23.101. ... transforming growth factor alpha MeSH D23.348.479.992.720 --- transforming growth factor beta MeSH D23.348.479.996 --- wnt ... beta subunit, human MeSH D23.101.840.375 --- hormones, ectopic MeSH D23.101.840.400 --- ki-67 antigen MeSH D23.101.840.500 --- ...

*Glycoprotein 130

... ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several other proteins which have structural ... It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common ... "Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ...

*Growth factor

Ciliary neurotrophic factor family *Ciliary neurotrophic factor (CNTF). *Leukemia inhibitory factor (LIF) ... The alpha granules in blood platelets contain growth factors PDGF, IGF-1, EGF, and TGF-β which begin healing of wounds by ... Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells. ... Migration-stimulating factor (MSF). *Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein ...

*List of MeSH codes (D12.776.543)

... receptor, ciliary neurotrophic factor MeSH D12.776.543.750.750.400.550.500 -- receptor, nerve growth factor MeSH D12.776. ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.543.325.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ... receptors, nerve growth factor MeSH D12.776.543.750.750.400.550.124 -- glial cell line-derived neurotrophic factor receptors ... receptors, platelet-derived growth factor MeSH D12.776.543.750.060.625.300 -- receptor, platelet-derived growth factor alpha ...
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Purpose: Cornea consists of anatomically distinct three layers, corneal epithelium (CEp), corneal stroma (CS), corneal endothelium (CEn), that have different developmental lineages and molecular functions. To reveal their transcriptional program, we performed spatial gene expression analysis of human cornea using next generation sequencer.. Methods: 100 ng of total RNA was extracted from the macroscopically dissected tissue fractions; CEp, CS, CEn, limbal epithelium (LEp) and conjunctiva (Cj) of the human donor corneoscleral tissue. For each sample, approximately 150 million of 100-bp, paired-end reads were sequenced (HiSeq2000, Illumina) and mapped against transcriptome database using BWA aligner. Quantity of 86,817 transcripts was corrected by gene/exon length (RPKM/FPKM), and then compared using regression analysis.. Results: 24,601 Transcript (28.3%) were expressed in common with all cell fractions. Global comparison of each spatial transcriptome showed that CS shows the closest pattern ...
Drake is reminding the world why he deserves the VIP treatment. Days after being negged from the NBA Finals after party, the Canadian Young Money ...
THREE officials of the New Bilibid Prisons (NBP) and seven others are facing administrative charges for the alleged Very Important Person (VIP) treatment of convicted drug lord and Sigue Sigue Sputnik gang commander Ricardo Camata alias "Chacha.". In a resolution signed by Secretary Leila de Lima, the head of the Department of Justice (DOJ) ordered the filing of charges against NBP superintendent Fajardo Lansangan, hospital head Dr. Gloria Achazo-Garcia, escort unit head Prison Supt. Gabriel Magan and medical specialist Dr. Ma. Cecilia Villanueva.. De Lima approved the findings of a fact-finding committee led by Undersecretary Francisco Baraan 3rd that prison guards Aldrid Garino, Antonio Bangoy, Eugenio Sabado, Edgardo Gamboa, Ernesto Calla and Herald Duran were liable for Camatas unauthorized confinement in a private hospital last June.. Charges of grave misconduct, gross neglect of duty and conduct prejudicial to the best interest of the service are expected to be filed against the ...
Principal Investigator:SUDA Toshihiro,堀場 伸郎, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:内分泌・代謝学
Gene Hackman spent the night at the Florida hospital where he was treated for injuries he received in a car vs. bike accident Friday ... but TMZ has…
CILIARY NEUROTROPHIC FACTOR VARIANTS - Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in SEQ ID: NO 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in SEQ ID: NO 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (CNTFR), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (IL-6R), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in SEQ ID: NO 2 having a non-positively charged amino acid residue ...
The relationship between ciliary neurotrophic factor CNTF genotype and motor unit physiology: preliminary studies. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Complete information for CNTF gene (Protein Coding), Ciliary Neurotrophic Factor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Gentaur molecular products has all kinds of products like :search , Sceti K.K. \ Humanin \ 4384-v for more molecular products just contact us
L~..Lary IUeurotroph~cPactor: Pharmacokrnetics m-d Acute-Phase Response in Rat Falk Dittrich, Hans Thoenen, and Michael Sendtnet Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circulation by the liver. No accumulation of radioactivity was detectable in nerve tissue or skeletal muscle after intravenous injection of 0.1 pg and 0.5 pg of CNTF. Radioactive degradation products accumulate in the skin. Liver cells express specific binding proteins for CNTF, and the incorporation and degradation of intravenously injected CNTF by the liver may occur after association of CNTF with the soluble CNTF receptor cu in the circulation. Probably a9 a consequence of its ...
A postdoctoral position is available in my laboratory in the areas of neurotrophic factor receptors, signal transduction and terminal differentiation of neural cells lines. Our studies include the structure of receptors, the roles of individual signal transduction pathways and the connection between neuronal differentiation and cell proliferation. My laboratory is located at the Worcester Foundation which offers a pleasant, relaxed atmosphere in a pretty suburban town near Boston. We are particularly eager to recruit a recent Ph.D. who would be eligible for a Neuroscience Training Grant recently awarded to the Worcester Foundation (American citizenship or Permanent Resident). The starting time is flexible. Some recent publications from our laboratory include: Timm et al. 1994. Circular dichroism studies of the interaction between four neurotrophins and the extracellular domain of the low affinity neurotrophin receptor. Protein Sci. 3, 451-458. Loy et al. 1994. Immunocytochemical localization of ...
This study examined the mechanisms underlying the long term functional outcome after bone marrow derived multipotent progenitor cell (MPC) transplantation in a porcine model of postinfarction Left Ventricular (LV) remodeling. Myocardial infarction (MI) was created by ligating the distal left anterior descending coronary artery (LAD). Intramyocardial injection of 50 million lacZ labeled MPC was performed in the periscar region (Cell, n=7) with 5 equal injections immediately after MI, while in control animals (CONT, n=7) saline was injected. Outcome was assessed with MRI and P-31 MRS. Engraftment was studied on histology and gene chip (Affymetrix) array analysis was used to study differential expression of genes in the two groups at 4 months. MPC treatment resulted in improvement of ejection fraction as early as 10 days after MI (32.2±9.5 vs. 43.4±5.1 in CONT and Cell respectively, p ,0.05). This improvement was seen each month and persisted up to 4 months (35.7±6.2 vs. 51.2±4.8 in CONT and ...
AGEs have been shown to accumulate in diabetic and ageing organs, including ocular tissues (cornea, lens,vitreous, and retina). Accumulation of AGEs in ECM was shown to elicit several changes of ECM including decreased solubility, decreased susceptibility to enzymes, and changes in such properties as thermal stability, mechanical strength, and stiffness. These changes in the physicochemical properties of ECM are believed to contribute, in part, to the development of age related changes and diabetic complications, including cardiovascular disease, retinopathy, nephropathy, indurated skin and joint stiffness. Albonet al reported a linear age related increase of pentocidine, an advanced glycation end product, in lamina cribrosa. Accumulation of AGEs in ECM of optic nerve heads in the elderly may decrease elasticity of lamina cribrosa and compromise the ability of cribriform plates to bear the strain caused by elevated intraocular pressure. The results of the current study showed that accumulation ...
The Patch (Ph) mutation in mice is a deletion of the gene encoding the platelet-derived growth factor receptor alpha subunit (PDGFR alpha). Patch is a recessive lethal recognized in heterozygotes by its effect on the pattern of neural crest-derived pigment cells, and in homozygous mutant embryos by visible defects in craniofacial structures. Since both pigment cells and craniofacial structures are derived from the neural crest, we have examined the differentiation of other crest cell-derived structures in Ph/Ph mutants to assess which crest cell populations are adversely affected by this mutation. Defects were found in many structures populated by non-neuronal derivatives of cranial crest cells including the thymus, the outflow tract of the heart, cornea, and teeth. In contrast, crest-derived neurons in both the head and trunk appeared normal. The expression pattern of PDGFR alpha mRNA was determined in normal embryos and was compared with the defects present in Ph/Ph embryos. PDGFR alpha mRNA ...
A recombinant version of human CNTF (rhCNTF), trade name Axokine, is a modified version with a 15 amino acid truncation of the C-terminus and two amino acid substitutions. It is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability properties.[6] Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. It was tested in the 1990s as a treatment for amyotrophic lateral sclerosis. It did not improve muscle control as much as expected, but trial participants did report a loss of appetite. Phase III clinical trials for the drug against obesity were conducted in 2003 by Axokines maker, Regeneron, demonstrating a small positive effect in some patients, but the drug was not commercialized. A major problem with the treatment was that in nearly 70% of the subjects tested, antibodies against Axokine were produced after approximately three months of treatment.[7] In the minority of subjects who did not develop the antibodies, weight loss ...
The views presented here are those of the author and are not to be construed as official or reflecting the views of the Uniformed Services University of the Health Sciences, the Department of Defense or the U.S. Government ...
After hearing arguments daylong by the defence and prosecution in the infamous Jammu and Kashmir sex scandal, the District and Sessions Judge, Mr BS Mehndiratta, today fixed October 9 for pronouncing orders on the bail pleas of 13 accused in the case. However, arguments for framing of charges were not held. Of the total 14 accused in the case, one Iqbal Khandey, an IAS officer, is out on interim bail.. During the course of proceedings, the judge adjourned the case for an hour in the afternoon. Amidst heavy security arrangements outside, the accused were allowed to meet their relatives inside the courtroom during adjournment in the light of the alleged controversy over the Chandigarh Police giving them VIP treatment in the Sector 17 police station. After the arguments ended, the accused were whisked away into a bus before being escorted to the Burail Jail. For the second consecutive time, the District and Sessions Judge did not allow the media in the court. However, no written orders were passed ...
Animals and genotyping. LIFR +/− mice generated on the B6,129/J genetic background and C57BL6 STOCK (for expanding theLIFR +/− mice) were obtained from The Jackson Laboratory (Bar Harbor, ME). Mice were then bred to allow for the generation of homozygote, heterozygote, and wild-type littermates (Koblar et al., 1998). The genotyping of mice carryingLIFR mutations was performed as described previously (Ware et al., 1995). CD-1 mice stocks were maintained in the University of Calgary Bioscience Animal Resources Center.. Neural stem cell culture and growth factors. Generation and differentiation of spheres from embryonic and adult forebrain were performed as described previously with minor modifications (Reynolds and Weiss, 1992; Reynolds et al., 1992). Briefly, striato-pallidum complexes were removed from mouse embryos at E14 and collected into PBS containing 0.6% glucose, penicillin (50 U/ml), and streptomycin (50 U/ml; both from Life Technologies, Gaithersburg, MD) and then transferred into ...
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CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of…
Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor, and the mechanisms by which CNTF expression could be increased in the brain are poorly understood. Acetylsalicylic acid (aspirin) is one of the most widely used analgesics. Interestingly, aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. Aspirin induced the activation of protein kinase A (PKA) but not protein kinase C (PKC). H-89, an inhibitor of PKA, abrogated aspirin-induced expression of CNTF ...
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The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.. With the intention to gain knowledge about systems that can be used to decrease RGC death after ONT, we have studied growth factor receptors belonging to the tyrosine kinase family of receptors (RTK), known to mediate important cell survival signals. We found that the RTK Ret and its coreceptor GFRα1 were expressed by RGCs, and to test the above-mentioned hypothesis, we intraocularly administered glial cell-line derived factor, which activates a Ret-GFRα1 complex, and found transiently mediated RGC survival after ONT.. To identify new, potential neurotrophic factor receptors expressed by RGCs, with the aim to improve RGC ...
Astrocytes are activated by ciliary neurotrophic factor (CNTF) in vivo and in vitro, however, the consequences on the L-type calcium channel (LCC) of neurons are still poorly understood. Therefore, in the present study, whole-cell patch clamp, western-blot and RT-PCR assay were performed to evaluate the effects of CNTF-treated astrocyte conditioned medium (CNTF-ACM) on LCC current (I(Ca)-L) and the expression of Cav1.2 and Cav1.3 in Sprague-Dawley rat cortical neurons. The results revealed that CNTF-ACM enhanced the amplitude of Ica-L and the expression of Cav1.3 significantly, but had no effects on Cav1.2 expression. We also found an increase in the concentration of fibroblast growth factor-2 (FGF-2) in CNTF-ACM by ELISA assay. Taken together, these findings indicate that CNTF induces the release of factors, including FGF-2, from astrocytes, thereby potentiating the activity of LCC in cortical neurons.. ...
Its a homecoming for Fodder scam convict and former Bihar chief minister Lalu Prasad. After being convicted in fodder scam Lalu on Saturday put in the same upper division cell where he stayed after the 2013 conviction in Ranchis Birsa Munda Jail, highly placed sources in the jail informed.. In the upper division cell, he will be entitled to avail one mosquito net, one newspaper to read every day, and a television set apart from the usual cell bed. Sources said that he can have access to home-cooked food in the jail and also prepare food for himself. The former railway minister had undergone a heart surgery in 2014 and has several restrictions in his diet.. The RJD chief and former Bihar chief minister will get VIP treatment in the prison. Other jail inmates will not be allowed to meet him during his stint here, jail officials said.. Rashtriya Janata Dal (RJD) leaders, including state party president and former minister Annapurna Devi accompanied Lalu in separate vehicles up to the jails main ...
Verizon Wireless announced the winner of its KCON Flyaway Sweepstakes last Friday, Oct. 5. Nancy Lee and three of her friends will be flying to Irvine, Calif. to experience KCON, the first convention of Korean culture in North America. As the grand prize winner, Lee and her friends will receive a free flight, hotel accommodations, dinner with K-pop group NUEST, and other VIP treatment at the event, which runs all day on Oct. 13.. KCON is one of the first Korean culture events not to focus solely on Korean pop music, also known as K-pop. In addition to musical performances by groups 4Minute, VIXX, B.A.P. Exo-M, G.NA and NUEST, there will also be several panels throughout the day, covering things from fashion, to online gaming, to speed dating.. "Its going to be a whirlwind of fun," Lee said. "Im going to live it up as much as I can.". Lee was chosen randomly from among thousands of entries from California and Washington state. (end). ...
To identify and characterize the Retinal stem/progenitor properties of Human Iris Pigment Epithelial (IPE) cells and Ciliary Epithelial (CE) cells in vitro. In this project we are working on the isolation and characterization of the retinal stem cells from the Iris and ciliary pigment epithelial cells invitro, which would facilitate us to find an alternative therapy for the treatment of retinal degenerative disorders. ...
title: Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia, doi: 10.1016/j.cellsig.2014.11.003, category: Article
The purpose of this study is to compare the success of storing a donor cornea in Optisol GS, the current standard vs. storing the donor cornea in Life4°C, a newer solution. The donor cornea to be used for EK will be provided by an eye bank and will have been stored in either an Optisol GS solution or a Life 4°C solution. At 6 months, the doctors will determine whether there are any comparable differences in cell loss and graft clarity between the two donor corneas ...
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified. GRCh38: Ensembl release 89: ENSG00000137070 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Patient Presentation A 53-day-old former 32 week premature female came to clinic for her health supervision visit after discharge from the neonatal intensive care unit. She had been discharged 3 days ago and her parents reported that overall they were doing well. She had had a couple of spit-up episodes after feedings that were random…
Neurotech Pharmaceuticals, Inc., in collaboration with the Lowy Medical Research Institute (LMRI), has announced 24-month results demonstrating that NT-501 delivering Ciliary Neurotrophic Factor (CNTF) has a beneficial effect in patients with Macular Telangiectasia type 2 (MacTel). The multicenter, randomized clinical trial demonstrated a statistically significant reduction in the progressive loss of photoreceptors in treated versus untreated eyes. NT-501 utilizes the Companys proprietary Encapsulated Cell Therapy (ECT) platform that can be customized to deliver specific therapeutic molecules to the back of the eye for retinal disease.. [Read More]. ...

The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to...The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to...

Leukemia Inhibitory Factor Receptor alpha Subunit. *Lifr protein, mouse. *Membrane Glycoproteins. *Receptor, Ciliary ... The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11285233

Ciliary neurotrophic factor - wikidocCiliary neurotrophic factor - wikidoc

"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica acta Helvetiae. 74 (2-3): 265-72. doi: ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor.[12][13] ...
more infohttps://www.wikidoc.org/index.php/Ciliary_neurotrophic_factor

CNTFR (human)CNTFR (human)

Ciliary neurotrophic factor receptor subunit alpha Show on y-axis - References (HTP + LTP). References (LTP). References (HTP) ...
more infohttps://www.phosphosite.org/proteinAction.action?id=10124&showAllSites=true

Anti-CNTFR antibody (ab175387) | AbcamAnti-CNTFR antibody (ab175387) | Abcam

Ciliary neurotrophic factor receptor subunit alpha antibody. *CNTF Receptor alpha antibody. *CNTF receptor subunit alpha ... Ciliary neurotrophic factor receptor alpha antibody. *Ciliary neurotrophic factor receptor antibody. * ... Belongs to the type I cytokine receptor family. Type 3 subfamily.. Contains 2 fibronectin type-III domains.. Contains 1 Ig-like ... appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor ...
more infohttps://www.abcam.com/cntfr-antibody-ab175387.html

Ciliary neurotrophic factor receptor - WikipediaCiliary neurotrophic factor receptor - Wikipedia

Ciliary Neurotrophic Factor Receptor alpha Subunit at the US National Library of Medicine Medical Subject Headings (MeSH). ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. doi:10.1126/science.1648265. PMID 1648265. Sleeman ...
more infohttps://en.wikipedia.org/wiki/Ciliary_neurotrophic_factor_receptor

humchr09.txthumchr09.txt

HUMAN 118946 Ciliary neurotrophic factor receptor subunit alpha precursor (CNTF receptor subunit alpha) (CNTFR-alpha) CNTLN ... HUMAN 600939 Interleukin-11 receptor subunit alpha precursor (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R- ... Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) ( ... SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF ...
more infohttp://www.uniprot.org/docs/humchr09

CNTFR related Antibodies, Proteins, cDNA and ELISA Kits- CusabioCNTFR related Antibodies, Proteins, cDNA and ELISA Kits- Cusabio

Ciliary neurotrophic factor receptor subunit alpha is a protein in humans that is encoded by CNTFR gene. Binds to CNTF. The ... Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Chicken Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Mouse Ciliary neurotrophic factor receptor subunit alpha(Cntfr). Yeast. E.coli. Baculovirus. Mammalian cell. ...
more infohttps://www.cusabio.com/target/CNTFR.html

Interleukin 11 receptor alpha subunit - WikipediaInterleukin 11 receptor alpha subunit - Wikipedia

This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ... 2003). "Expression and function of interleukin-11 and its receptor alpha in the human endometrium". Mol. Hum. Reprod. 9 (2): 75 ...
more infohttps://en.wikipedia.org/wiki/Interleukin_11_receptor_alpha_subunit

LIFR Gene - GeneCards | LIFR Protein | LIFR AntibodyLIFR Gene - GeneCards | LIFR Protein | LIFR Antibody

LIF Receptor Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Ciliary neurotrophic factor receptor alpha subunit. *307. Human Protein Atlas (HPA):. *Cancer-related genes ... to ciliary neurotrophic factor receptor activity. IDA. 12643274. GO:0004923. contributes_to leukemia inhibitory factor receptor ... contributes_to oncostatin-M receptor activity. IDA. 8999038. GO:0005127. ciliary neurotrophic factor receptor binding. IPI. ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=LIFR

lifr, leukemia inhibitory factor receptor alpha - Creative Biogenelifr, leukemia inhibitory factor receptor alpha - Creative Biogene

... including the ciliary neurotrophic factor, growth hormone and prolactin. ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that ... LIFR; Interferon α Receptor β Chain; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; ... FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor; cytokine receptor-beta ...
more infohttps://www.creative-biogene.com/symbolsearch_lifr.html

View source for Template:Cytokines - wikidocView source for Template:Cytokines - wikidoc

Ciliary neurotrophic factor,CNTF]] ** [[Cardiotrophin 1,CTF1]] , group6 = [[IL12 family]]/[[Interleukin 12 receptor, beta 1 ... Tumor necrosis factors,TNF]] , list2 = * [[Tumor necrosis factor alpha,TNFA]] * [[Lymphotoxin]] ** [[Lymphotoxin alpha,TNFB/LTA ... Type I cytokine receptor,Type I]],br>(grouped by,br>receptor,br>subunit) , list1 = {{Navbox,subgroup , group1 = [[Common gamma ... Stem cell factor,KITLG]] ** [[Colony-stimulating factor]] * [[Osteopontin,SPP1]] * [[Macrophage migration inhibitory factor,MIF ...
more infohttps://www.wikidoc.org/index.php?title=Template:Cytokines&action=edit

Antigens, CD14 | Harvard Catalyst Profiles | Harvard CatalystAntigens, CD14 | Harvard Catalyst Profiles | Harvard Catalyst

Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... Interleukin-6 Receptor alpha Subunit. *Interleukin-7 Receptor alpha Subunit. *Leukemia Inhibitory Factor Receptor alpha Subunit ... They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. ... Interleukin-3 Receptor alpha Subunit. *Interleukin-4 Receptor alpha Subunit. *Interleukin-5 Receptor alpha Subunit ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Antigens,%20CD14

CNTF Receptor alpha ELISA & Assay KitsCNTF Receptor alpha ELISA & Assay Kits

Compare and order CNTF Receptor alpha ELISA试剂盒. View citations, images, detection ranges, sensitivity, prices and more. ... CNTFR-alpha , ciliary neurotrophic factor receptor subunit alpha , CNTFR alpha , ciliary neurotrophic factor receptor alpha , ... growth-promoting activity receptor subunit alpha , ciliary neurotrophic factor receptor , ciliary neurotrophic factor receptor ... ciliary neurotrophic factor receptor subunit alpha preproprotein , GPA receptor subunit alpha , GPAR-alpha , growth promoting ...
more infohttps://www.antibodies-online.cn/jak/stat-signaling-pathway-6/cntf-receptor-alpha-elisa-kit-2715/

Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease PatientsEncapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease Patients

BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.. Receptor, Nerve Growth Factor ... It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity. ... Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes ... A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4. ...
more infohttps://www.bioportfolio.com/resources/trial/62788/Encapsulated-Cell-Biodelivery-of-Nerve-Growth-Factor-to-Alzheimer-s-Disease-Patients.html

Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible...Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible...

Membrane-bound transcription factor site-1 protease (S1P) is an emerging clinical target due to its roles in lipogenesis, ... The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the ... Leukemia Inhibitory Factor Receptor Alpha Subunit. A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the ... Nuclear Receptor Coactivator 2. A transcription factor that partners with ligand bound GLUCOCORTICOID RECEPTORS and ESTROGEN ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2451052/Membrane-Bound-Transcription-Factor-Site-1-Protease-in-PF429242-Bound-State-Computational.html

GP130 Antibody, PE (12-1302-82)
                
                
		        
	GP130 Antibody, PE (12-1302-82)

... leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding ... Oncostatin-M receptor subunit alpha ... cytokine receptor activity ciliary neurotrophic factor receptor ... ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part ... oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6ST; ...
more infohttps://www.thermofisher.com/antibody/product/GP130-Antibody-clone-KGP130-Monoclonal/12-1302-82

Recombinant Human Interleukin 6 Receptor IL6R-1242H - Creative BioMartRecombinant Human Interleukin 6 Receptor IL6R-1242H - Creative BioMart

ciliary neurotrophic factor binding;ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6receptor ... Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2;Membrane glycoprotein 80; interleukin 6 receptor; ... interleukin 6 receptoralpha subunit.. Gene ID:. 3570. mRNA Refseq:. NM_000565. Protein Refseq:. NP_000556. ... IL6R interleukin 6 receptor [ Homosapiens ]. Synonyms:. IL6R; interleukin 6receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; ...
more infohttps://www.creativebiomart.net/description_106911_19.htm

Stefan Heller | Stanford Medicine ProfilesStefan Heller | Stanford Medicine Profiles

The expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) was investigated in the developing chick dorsal root ... of heteromeric receptor complexes and depend on the presence of the ligand-binding receptor subunits CNTFR alpha and GPAR alpha ... Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during ... Growth promoting activity (GPA) is a chick growth factor with low homology to mammalian ciliary neurotrophic factor (CNTF) (47 ...
more infohttps://med.stanford.edu/profiles/stefan-heller

Recombinant Human IL6R, C13&N15-labeled IL6R-239H - Creative BioMartRecombinant Human IL6R, C13&N15-labeled IL6R-239H - Creative BioMart

ciliary neurotrophic factor binding; contributes_to ciliary neurotrophic factor receptor activity; enzyme binding; interleukin- ... interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.[1-4]. ... IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. ...
more infohttps://www.creativebiomart.net/description_391764_12.htm

Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website

... member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of… ... Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral ... leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the ... CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the ...
more infohttps://www.acris-antibodies.com/target/cntfr-antibody.htm?ab_ag_presentation=Purified

Human IL6R ELISA Kit | biobool.comHuman IL6R ELISA Kit | biobool.com

Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor. Ligand binding did not ... Human IL-6 receptor subunit alpha ELISA Kit;Human IL-6R subunit alpha ELISA Kit;Human IL-6R-alpha ELISA Kit;Human IL-6RA ELISA ... Human interleukin 6 receptor ELISA Kit;Human interleukin-6 receptor subunit alpha ELISA Kit;Human CD126 antigen ELISA Kit;. ... is a type I cytokine receptor. The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and ...
more infohttps://www.biobool.com/elisa_kit/19510.html

IMP: Integrative Multi-species PredictionIMP: Integrative Multi-species Prediction

transforming growth factor, beta receptor II. 0.031. Cacna1c. calcium channel, voltage-dependent, L type, alpha 1C subunit. ... ciliary neurotrophic factor receptor. 0.032. Syt3. synaptotagmin III. 0.032. Igfbp5. insulin-like growth factor binding protein ... nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. 0.599. ... colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage). 0.697. ...
more infohttp://imp.princeton.edu/predictions/process_ortho/human-context-global/502/?gene=20362

KEGG PATHWAY: hsa04630KEGG PATHWAY: hsa04630

CNTFR; ciliary neurotrophic factor receptor [KO:K05059]. 1438 CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO: ... IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]. 3455 IFNAR2; interferon alpha and beta receptor subunit 2 [KO ... IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]. 3598 IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077] ... IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]. 116379 IL22RA2; interleukin 22 receptor subunit alpha 2 [KO: ...
more infohttps://www.kegg.jp/dbget-bin/www_bget?hsa04630

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant...Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant...

Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. Mol Vis. 2005; ... Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vision Res ... and it may suggest an interspecies difference as also found for the receptor of ciliary neurotrophic factor.40 Although ... Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2599023
  • The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes . (wikidoc.org)
  • A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease . (wikidoc.org)
  • It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks . (wikidoc.org)
  • The activation of a naive T-Cell requires two signals: ligation of the TCR (T-Cell Receptor) with the MHC (Major Histocompatibility Complex)/peptide complex on the APC (Antigen Presenting Cell). (qiagen.com)
  • Combinatorial chemistry technology: method, library, apparatus method of screening a library by measuring the ability to specifically bind a target molecule (e.g., antibody-antigen binding, receptor-ligand binding, etc. (patentsencyclopedia.com)
  • Bayas A, Kruse N, Moriabadi NF, Weber F, Hummel V, Wohleben G, Gold R, Toyka KV, Rieckmann P (2003) Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve-growth factor in human immune cells. (springer.com)
  • Besser M, Wank R (1999) Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. (springer.com)
  • Braun A, Lommatzsch M, Mannsfeldt A, Neuhaus-Steinmetz U, Fischer A, Schnoy N, Lewin GR, Renz H (1999) Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. (springer.com)
  • Inhibiting NF-κB activation with super-repressor IκB-α, BAY 11 7082 (IκB-α phosphorylation inhibitor) or N-acetyl-Leu-Leu-norleucinal (proteosomal degradation inhibitor), or inhibiting NF-κB transcriptional activity with κB decoy DNA substantially reduced the size and complexity of the neurite arbors of sensory neurons cultured with brain-derived neurotrophic factor while having no effect on their survival. (biologists.org)
  • Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J. The soluble interleukin 6 receptor: generation and role in inflammation and cancer. (springer.com)
  • Erices, Conget, Rojas, Minguell: Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. (antikoerper-online.de)
  • 1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. (wikipedia.org)
  • Circulating IL-6 and muscle IL-6 mRNA and IL-6 receptor response muscle lengthening contractions (MLC). (bio-rad-antibodies.com)
  • The studies presented herein show that a broad spectrum of antimalarial drugs augmented the replication of SFV in mice, concomitant with greater tissue damage and up-regulation of mRNA levels of various inflammatory cytokine genes, including interleukin-1 receptor antagonist (IL-1Ra), II-1alpha, IL-1beta, IL-6, IL-12p40, and interferon-gamma inducing factor. (ajtmh.org)
  • The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). (abcam.co.jp)
  • Both the α and β subunits are synthesized from a single mRNA precursor. (thefullwiki.org)
  • For example, epidermal growth factor (EGF) enhances osteogenic differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation ( angiogenesis ). (wikipedia.org)
  • The pharmacology of Nerve Growth Factor (NGF) and the discovery and development of tanezumab, a monoclonal anti-NGF antibody for the treatment of pain illustrate the complex and unpredictable nature o. (bioportfolio.com)
  • A monoclonal antibody from mouse specific for IL-6R Alpha has been precoated onto 96-well plates. (biobool.com)
  • Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic. (bioportfolio.com)
  • Standards(sf21,L20-D358) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for IL-6R Alpha is added subsequently and then followed by washing with PBS or TBS buffer. (biobool.com)
  • The anti-GDNF antibody-stained cells in the facial nucleus were almost coincident with the anti-NMDA receptor 3B subunit (NR3B) antibody-positive cells, suggesting that the former were motoneurons. (alliedacademies.org)
  • Glial cell line-derived neurotrophic factor (GDNF) from rats (G1401) and anti-human GDNF antibody (G8035) that can detect rat GDNF were purchased from Sigma-Aldrich Japan (Tokyo, Japan). (alliedacademies.org)
  • The antibody against NMDA receptor 3B subunit (NR3B) (ab35677) used for identifying motoneurons was supplied by Abcam (Cambridge, UK). (alliedacademies.org)
  • Thus, GDNF is considered a survival factor for neonatal motoneurons that is retrogradely transported from facial muscle. (alliedacademies.org)
  • However, GDNF administration prevents the reduction of choline acetyltransferase levels in injured motoneurons [ 7 ], suggesting that target-derived GDNF functions as a regulator of cellular metabolism/function rather than as a survival factor in adulthood. (alliedacademies.org)
  • Nuclear factor-kappa B (NF-κB) is classically known for its ubiquitous roles in inflammation, immune and stress-related responses and regulation of cell survival in all tissues, including the nervous system. (biologists.org)
  • Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. (springer.com)