Ciliary Neurotrophic Factor Receptor alpha Subunit
Receptor, Ciliary Neurotrophic Factor
Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
Ciliary Neurotrophic Factor
Receptors, Nerve Growth Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Receptor, Platelet-Derived Growth Factor alpha
Brain-Derived Neurotrophic Factor
Glial Cell Line-Derived Neurotrophic Factor Receptors
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.
Nerve Growth Factors
Receptor, trkB
Databases, Protein
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Receptors, Cytokine
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Cytokine Receptor gp130
Biotechnology
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Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
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Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. (1/16)
PURPOSE: Ciliary neurotrophic factor (CNTF) promotes gene expression, cell survival and differentiation in various types of peripheral and central neurons, glia and nonneural cells. The level of CNTF rises rapidly upon injury to neural tissue, suggesting that CNTF exerts its cytoprotective effects after release from cells via mechanisms induced by cell injury. The purpose of this study was to determine if cells in the optic nerve head express CNTF and its tripartite receptor complex. METHODS: Well-established optic nerve head astrocytes (ONHA) and lamina cribrosa (LC) cell cultures were derived from normal human donors. Total RNA was reverse transcribed and polymerase chain reaction (PCR) amplified for mRNA detection. Cytoplasmic protein expression was determined by immunocytochemistry and Western blot analysis of the cellular lysates. Serum free medium was concentrated and used for detecting extracellular proteins. CNTF complexed with CNTFR-alpha was assayed by immunoprecipitation. RESULTS: Cells isolated from the human optic nerve head express CNTF and its tripartite receptor complex members (CNTFR-alpha, gp130, LIFR-beta). CONCLUSIONS: Taken together, these data suggest a possible neuroprotective role of CNTF in the optic nerve head. (+info)Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. (2/16)
Intrauterine nutrition status is reported to correlate with risk of cardiovascular diseases in adulthood. Either under- or overnutrition during early to mid gestation contributes to altered fetal growth and ventricular geometry. This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. Multiparous ewes were fed with 50% [nutrient-restricted (NR)], 100% (control) or 150% [overfed (OF)] of National Research Council requirements from 28 to 78 days of gestation (dG; term, 148 dG). Ewes were euthanized on Day 78, and the gravid uteri and fetuses recovered. Ventricular protein expression of CNTFRalpha, STAT3, phosphorylated STAT3, insulin-like growth factor I receptor (IGF-1R), and IGF binding protein 3 (IGFBP3) were quantitated using Western blot. Plasma cortisol levels were higher in both NR and OF fetuses, whereas plasma IGF-1 levels were lower and higher in NR and OF fetuses. Fetal weights were reduced by 29.9% in NR ewes and were increased by 22.2% in fetuses from OF ewes compared to control group. Nutrient restriction did not affect fetal heart or ventricular weights, whereas overfeeding increased heart and ventricular weights. Protein expression of CNTFRalpha in fetal ventricular tissue was reduced in OF group, whereas STAT3 and phosphorylated STAT3 levels were reduced in both NR and OF groups. Expression of IGF-1R and IGFBP3 was unaffected in either NR or OF group. These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role. (+info)Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth. (3/16)
Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF) have met with limited success. The variability of results obtained with CNTF may, in part, reflect the fact that some of the biological actions of the cytokine are mediated by a complex formed between CNTF and its specific receptor, CNTFRalpha, which exists in both membrane-bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF complexed with soluble CNTFRalpha (hereafter termed "Complex") on neuronal survival and growth. Although CNTF alone produced limited effects, Complex protected against glutamate-mediated excitotoxicity via gap junction-dependent and -independent mechanisms. Further examination revealed that only Complex promoted neurite outgrowth. Differential gene expression analysis revealed that, compared with CNTF alone, Complex differentially regulates several neuroprotective and neurotrophic genes. Collectively, these findings indicate that CNTF exerts more robust effects on neuronal survival and growth when applied in combination with its soluble receptor. (+info)Neuroinflammation facilitates LIF entry into brain: role of TNF. (4/16)
(+info)A putative physiological role of hypothalamic CNTF in the control of energy homeostasis. (5/16)
(+info)CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons. (6/16)
(+info)Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation. (7/16)
(+info)Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia. (8/16)
(+info)
The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to...
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Ciliary neurotrophic factor receptor
Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi:10.1126/science. ...
Interleukin 11 receptor alpha subunit
This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ...
Interleukin 31
This family includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor ( ... IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. ... The receptor for IL-31 is a heterodimer of the interleukin 31 receptor alpha (IL-31RA) and OSMR. IL-31RA was originally ... These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31RA binds IL-31 through ...
Leukemia inhibitory factor receptor
"The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor (LIF) is a polyfunctional cytokine ... including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to ... Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ ...
Interleukin-6 receptor
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer ... Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor. Cluster of ... Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein ...
Ciliary neurotrophic factor
"Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for ... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor. Ciliary neurotrophic factor ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica Acta Helvetiae. 74 (2-3): 265-72. doi: ...
CLCF1
2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional ... It induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor ... specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component". J. Biol. Chem. 276 ( ... 2006). "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold- ...
Janus kinase 1
... cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ... 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045 ... "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". ...
Glycoprotein 130
... ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several other proteins which have structural ... It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common ... "Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated ... Glycoprotein 130 has been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, ...
List of MeSH codes (D23)
... brain-derived neurotrophic factor MeSH D23.348.479.875.212 - ciliary neurotrophic factor MeSH D23.348.479.875.325 - glia ... receptors, tumor necrosis factor, type i MeSH D23.050.301.264.035.912 - receptors, tumor necrosis factor, type ii MeSH D23.050. ... transforming growth factor alpha MeSH D23.348.479.992.720 - transforming growth factor beta MeSH D23.348.479.996 - wnt proteins ... beta subunit, human MeSH D23.101.840.375 - hormones, ectopic MeSH D23.101.840.400 - ki-67 antigen MeSH D23.101.840.500 - ...
Growth factor
Ciliary neurotrophic factor family *Ciliary neurotrophic factor (CNTF). *Leukemia inhibitory factor (LIF) ... The alpha granules in blood platelets contain growth factors PDGF, IGF-1, EGF, and TGF-β which begin healing of wounds by ... Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells. ... Migration-stimulating factor (MSF). *Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein ...
List of MeSH codes (D12.776.543)
... receptor, ciliary neurotrophic factor MeSH D12.776.543.750.750.400.550.500 - receptor, nerve growth factor MeSH D12.776.543.750 ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... receptor, platelet-derived growth factor alpha MeSH D12.776.543.750.060.625.400 - receptor, platelet-derived growth factor beta ... receptors, nerve growth factor MeSH D12.776.543.750.750.400.550.124 - glial cell line-derived neurotrophic factor receptors ...
GDE3 regulates oligodendrocyte precursor proliferation via release of soluble CNTFRα
... mechanisms that modulate cellular responses to these factors remain unclear. Six-transmembrane glycerophosphodiester ... Ciliary Neurotrophic Factor / metabolism * Ciliary Neurotrophic Factor Receptor alpha Subunit / metabolism* * Cytokines / ... GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα ... the ligand-binding component of the CNTF-receptor multiprotein complex, which can function as a soluble factor to activate CNTF ...
CNTFR (human)
Anti-CNTFR antibody (ab175387) | Abcam
Ciliary neurotrophic factor receptor subunit alpha antibody. *CNTF Receptor alpha antibody. *CNTF receptor subunit alpha ... Ciliary neurotrophic factor receptor alpha antibody. *Ciliary neurotrophic factor receptor antibody. * ... Belongs to the type I cytokine receptor family. Type 3 subfamily.. Contains 2 fibronectin type-III domains.. Contains 1 Ig-like ... appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor ...
Anti-CNTFR antibody [MM0190-10L29] (ab89333) | Abcam
Ciliary neurotrophic factor receptor subunit alpha antibody. *CNTF Receptor alpha antibody. *CNTF receptor subunit alpha ... Ciliary neurotrophic factor receptor alpha antibody. *Ciliary neurotrophic factor receptor antibody. * ... Perugini J et al. Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes. Front Endocrinol (Lausanne) 10:768 ( ... Belongs to the type I cytokine receptor family. Type 3 subfamily.. Contains 2 fibronectin type-III domains.. Contains 1 Ig-like ...
Ciliary neurotrophic factor receptor - Wikipedia
Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2-3): 265-72. doi:10.1016/S0031-6865(99) ... "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59-63. Bibcode:1991Sci...253...59D. doi:10.1126/science. ...
humchr09.txt
HUMAN 118946 Ciliary neurotrophic factor receptor subunit alpha precursor (CNTF receptor subunit alpha) (CNTFR-alpha) CNTLN ... HUMAN 600939 Interleukin-11 receptor subunit alpha precursor (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R- ... Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) ( ... SNAPc subunit 3) (Proximal sequence element-binding transcription factor subunit beta) (PSE-binding factor subunit beta) (PTF ...
CNTFR related Antibodies, Proteins, cDNA and ELISA Kits- Cusabio
Ciliary neurotrophic factor receptor subunit alpha is a protein in humans that is encoded by CNTFR gene. Binds to CNTF. The ... Recombinant Human Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Chicken Ciliary neurotrophic factor receptor subunit alpha(CNTFR). Yeast. E.coli. Baculovirus. Mammalian cell. ... Recombinant Mouse Ciliary neurotrophic factor receptor subunit alpha(Cntfr). Yeast. E.coli. Baculovirus. Mammalian cell. ...
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Ciliary neurotrophic factor receptor subunit alpha; Discoidin, CUB and LCCL domain-containing protein 2; Ephrin-B2; Leucine- ... Ciliary neurotrophic factor receptor subunit alpha (CNTFR); Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2); ... Complement factor H-related 1. CNTFR:. Ciliary neurotrophic factor receptor subunit alpha ... Either way, IR is potentially a modifiable risk factor for AD; however, it is still unclear exactly how and at what stage IR ...
The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to...
Leukemia Inhibitory Factor Receptor alpha Subunit. *Lifr protein, mouse. *Membrane Glycoproteins. *Receptor, Ciliary ... The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ... The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to ...
Interleukin 11 receptor alpha subunit - Wikipedia
This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2- ... Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. Interleukin 11 is ... "Entrez Gene: IL11RA interleukin 11 receptor, alpha". Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two ... 2007). "Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the ...
LIFR Gene - GeneCards | LIFR Protein | LIFR Antibody
LIF Receptor Alpha, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Ciliary neurotrophic factor receptor alpha subunit. *307. Human Protein Atlas (HPA):. *Cancer-related genes ... to ciliary neurotrophic factor receptor activity. IDA. 12643274. GO:0004923. contributes_to leukemia inhibitory factor receptor ... contributes_to oncostatin-M receptor activity. IDA. 8999038. GO:0005127. ciliary neurotrophic factor receptor binding. IPI. ...
Ephrin-A4 | Harvard Catalyst Profiles | Harvard Catalyst
GPI-Linked Proteins | Harvard Catalyst Profiles | Harvard Catalyst
View source for Template:Cytokines - wikidoc
Ciliary neurotrophic factor,CNTF]] ** [[Cardiotrophin 1,CTF1]] , group6 = [[IL12 family]]/[[Interleukin 12 receptor, beta 1 ... Tumor necrosis factors,TNF]] , list2 = * [[Tumor necrosis factor alpha,TNFA]] * [[Lymphotoxin]] ** [[Lymphotoxin alpha,TNFB/LTA ... Type I cytokine receptor,Type I]],br>(grouped by,br>receptor,br>subunit) , list1 = {{Navbox,subgroup , group1 = [[Common gamma ... Stem cell factor,KITLG]] ** [[Colony-stimulating factor]] * [[Osteopontin,SPP1]] * [[Macrophage migration inhibitory factor,MIF ...
Leukemia Inhibitory Factor Receptor alpha Subunit | Profiles RNS
Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]. *Leukemia Inhibitory Factor Receptor alpha Subunit [ ... Leukemia Inhibitory Factor Receptor alpha Subunit*Leukemia Inhibitory Factor Receptor alpha Subunit ... Receptors, OSM-LIF [D12.776.543.750.705.852.500]. *Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852. ... Receptors, OSM-LIF [D12.776.543.750.705.852.555.800]. *Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750. ...
CNTF Receptor alpha ELISA & Assay Kits
Compare and order CNTF Receptor alpha ELISA试剂盒. View citations, images, detection ranges, sensitivity, prices and more. ... CNTFR-alpha , ciliary neurotrophic factor receptor subunit alpha , CNTFR alpha , ciliary neurotrophic factor receptor alpha , ... growth-promoting activity receptor subunit alpha , ciliary neurotrophic factor receptor , ciliary neurotrophic factor receptor ... ciliary neurotrophic factor receptor subunit alpha preproprotein , GPA receptor subunit alpha , GPAR-alpha , growth promoting ...
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Ciliary neurotrophic factor receptor subunit alpha,CNTF receptor subunit alpha,CNTFR,CNTFR-alpha,Gallus gallus,GPA receptor ... CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha ... CLIA IL-6 receptor subunit alpha,Il6r,IL-6R 1,IL-6R subunit alpha,Il6ra,IL-6RA,IL-6R-alpha,Interleukin-6 receptor subunit alpha ... ELISA IL-4 receptor subunit alpha,Il4r,IL-4R subunit alpha,Il4ra,IL-4RA,IL-4R-alpha,Interleukin-4 receptor subunit alpha,Mouse, ...
Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease Patients
BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.. Receptor, Nerve Growth Factor ... It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity. ... Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes ... A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4. ...
Il6st - Interleukin-6 receptor subunit beta - Rattus norvegicus (Rat) - Il6st gene & protein
ciliary neurotrophic factor receptor complex Source: Ensembl. *external side of plasma membrane Source: Ensembl ... Oncostatin-M receptor subunit alpha) (CD antigen CD130) ... Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta ... Interleukin-6 receptor subunit betaImported. ,p>Information which has been imported from another database using automatic ... tr,F1LPK1,F1LPK1_RAT Interleukin-6 receptor subunit beta OS=Rattus norvegicus OX=10116 GN=Il6st PE=1 SV=3 ...
Antigens, CD24 | Profiles RNS
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... Interleukin-3 Receptor alpha Subunit. *Interleukin-4 Receptor alpha Subunit. *Interleukin-5 Receptor alpha Subunit ... Leukemia Inhibitory Factor Receptor alpha Subunit. *Low Density Lipoprotein Receptor-Related Protein-1 ... Interleukin-18 Receptor alpha Subunit. *Interleukin-18 Receptor beta Subunit. *Interleukin-2 Receptor alpha Subunit ...
GlyConnect
2215 Ciliary neurotrophic factor receptor subunit alpha Mus musculus Q07409 # id : 2226 Contactin-3 Mus musculus Q9CPW0 # id : ... Isoform 2D of Voltage-dependent calcium channel subunit alpha-2/delta-1 / Mus musculus * Asn-324 ... Isoform 2D of Voltage-dependent calcium channel subunit alpha-2/delta-1 / Mus musculus * Asn-324 ... O08532-4 Asn-324 Isoform 2D of Voltage-dependent calcium channel subunit alpha-2/delta-1 / Mus musculus ...
Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible...
Membrane-bound transcription factor site-1 protease (S1P) is an emerging clinical target due to its roles in lipogenesis, ... The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the ... Leukemia Inhibitory Factor Receptor Alpha Subunit. A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the ... Nuclear Receptor Coactivator 2. A transcription factor that partners with ligand bound GLUCOCORTICOID RECEPTORS and ESTROGEN ...
KEGG BRITE: KEGG Orthology (KO) - Rattus norvegicus (rat)
688622 Il31ra; interleukin-31 receptor subunit alpha precursor 313173 Cntfr; ciliary neurotrophic factor receptor subunit alpha ... interleukin 27 receptor alpha K22630 IL31RA; interleukin 31 receptor subunit alpha K05059 CNTFR; ciliary neurotrophic factor ... 25084 Il4r; interleukin-4 receptor subunit alpha precursor 294797 Il7r; interleukin-7 receptor subunit alpha precursor 24500 ... 100360218 interleukin-13 receptor subunit alpha-1 171060 Il13ra2; interleukin-13 receptor subunit alpha-2 precursor 24336 Epor ...
GP130 Antibody, PE (12-1302-82)
... leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding ... Oncostatin-M receptor subunit alpha ... cytokine receptor activity ciliary neurotrophic factor receptor ... ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part ... oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6ST; ...
Recombinant Human Interleukin 6 Receptor IL6R-1242H - Creative BioMart
ciliary neurotrophic factor binding;ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6receptor ... Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2;Membrane glycoprotein 80; interleukin 6 receptor; ... interleukin 6 receptoralpha subunit.. Gene ID:. 3570. mRNA Refseq:. NM_000565. Protein Refseq:. NP_000556. ... IL6R interleukin 6 receptor [ Homosapiens ]. Synonyms:. IL6R; interleukin 6receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; ...
Stefan Heller | Stanford Medicine Profiles
The expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) was investigated in the developing chick dorsal root ... of heteromeric receptor complexes and depend on the presence of the ligand-binding receptor subunits CNTFR alpha and GPAR alpha ... Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during ... Growth promoting activity (GPA) is a chick growth factor with low homology to mammalian ciliary neurotrophic factor (CNTF) (47 ...
DeCS
Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.249] Ciliary Neurotrophic Factor Receptor ... of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the ... of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the ... 2000; CILIARY NEUROTROPHIC FACTOR RECEPTOR (now RECEPTOR, CILIARY NEUROTROPHIC FACTOR) was indexed under RECEPTORS, NERVE ...
Cytokine Receptor gp130 | Profiles RNS
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Cytokine Receptor gp130. *Leukemia Inhibitory Factor Receptor alpha ... Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]. *Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400. ... Receptors, Oncostatin M, Type II [D12.776.543.750.705.852.555.600]. *Cytokine Receptor gp130 [D12.776.543.750.705.852.555.600. ... A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS. ...
GPI-Linked Proteins | Profiles RNS
Ciliary Neurotrophic Factor Receptor alpha Subunit. *Contactins. *Ephrin-A1. *Ephrin-A2. *Ephrin-A3 ... The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant ... Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. Cancer Res. 2015 May ...
CytokinesCNTFROncostatinLigandNerve GrowthIL6ROSMRCNTF ReceptorCardiotrophin like cytokineInhibitory factorGlycoproteinLIFRIsoform2000CNTFRalphaInducesComplexesSignal transducerHeterodimericMurineSignalingProteinsGeneSpecificityPolypeptideKinaseCytokine receptor familySoluble formInterleukin-11 receptor alExpressionNeuronsHigh-affinity receptorTyrosine
Cytokines23
- Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. (wikipedia.org)
- Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (creative-biogene.com)
- The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). (thermofisher.com)
- The activation of this protein is dependent upon the binding of cytokines to their receptors. (thermofisher.com)
- IL6R subunit also shared by many other cytokines. (creativebiomart.net)
- IL-31 is unique in this family of cytokines because its receptor complex does not contain gp130. (wikidoc.org)
- In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. (kegg.jp)
- Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. (kegg.jp)
- These are heterodimeric cytokines composed of cardiotrophin-like cytokine (CLC) associated either with the soluble receptor subunit cytokine-like factor-1 (CLF) or the soluble form of the binding receptor itself (sCNTFR). (inserm.fr)
- The IL-6R shares many features with other receptors of the IL-6 family of cytokines, notably the interleukin-11 receptor (IL-11R) and the ciliary neurotrophic factor receptor (CNTFR) (Garbers et al. (springer.com)
- 2012 ). All these cytokines signal through the common β-receptor glycoprotein 130 (gp130). (springer.com)
- Hence, a novel negative crosstalk mechanism for cytokine signalling is described, where cytokine receptor turnover is regulated in trans by pro-inflammatory cytokines and stress stimuli to coordinate the inflammatory response. (uni.lu)
- The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. (uni.lu)
- IL-6-type cytokines exert their action via the signal transducers gp (glycoprotein) 130, LIF receptor and OSM receptor leading to the activation of the JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen-activated protein kinase) cascades. (uni.lu)
- Development and maintenance of the mammalian nervous system is dependent upon neurotrophic cytokines. (ed.ac.uk)
- One class of neurotrophic factor acts through receptor complexes involving the low-affinity leukaemia inhibitory factor receptor subunit (LIF-R). Members of this family of cytokines, such as ciliary neurotrophic factor (CNTF) and leukaemia inhibitory factor (LIF), have profound effects on the survival and maintenance of motor neurons. (ed.ac.uk)
- All of these cytokines act via a bi- or tripartite receptor complex in which signaling is triggered by homodimerization (IL6) or heterodimerization with LIF-Rb/gp190 protein (IL11, LIF, OSM, and CNTF) of gp130. (receptome.org)
- In these studies, members of the interleukin (IL)-6 family of cytokines including, leukemia inhibitory factor (LIF), IL-6, and ciliary neurotrophic factor (CNTF) and associated receptors, IL-6 receptor (R) α, LIFR, and gp130 were examined in the urinary bladder in control and CYP-treated rats. (frontiersin.org)
- Spanning nearly 150 select biomarkers including important cytokines, acute phase reactants, growth factors and cancer markers, ExplorerMAP can be utilized by drug and diagnostic developers in several therapy areas including inflammation, immune response, cardiovascular, neurological, metabolic and cancer. (myriadrbm.com)
- Molecules currently under study include receptors of the immune system involved in autoimmune disorders (T cell receptors, co-receptors, MHC, cytokines), proteins involved in host-pathogen interactions and molecular mimicry (CMV and Toxoplasma surface antigens), proteins of nervous system (peptide hormone receptors, neural guidance proteins), and membrane proteins (chemokine receptors). (stanford.edu)
- Larsen, Hansen, Møller, Madsen, Scheller, Nielsen, Petersen: Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. (antikoerper-online.de)
- The protein functions as a part of the cytokine receptor complex and its activation is dependent upon the binding of cytokines to their receptors. (cellsciences.com)
- All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes. (rndsystems.com)
CNTFR6
- GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function as a soluble factor to activate CNTF signaling. (nih.gov)
- The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. (wikipedia.org)
- Ciliary neurotrophic factor receptor subunit alpha is a protein in humans that is encoded by CNTFR gene. (cusabio.com)
- CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha component (CNTFR). (nih.gov)
- BACKGROUND: The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor alpha component (CNTFR). (inserm.fr)
- Moreover, blockade of the CNTF-specific receptor CNTFRα induced sensory nerve degeneration and retarded regeneration in normal corneas. (jci.org)
Oncostatin4
- A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. (uams.edu)
- gp130 is a subunit of several heterodimeric cell-surface receptors, including receptors for IL-6, IL-11, IL-27, Oncostatin M, and Leukemia Inhibitory Factor (LIF). (thermofisher.com)
- Auf www.antikoerper-online.de finden Sie aktuell 338 Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper von 25 unterschiedlichen Herstellern. (antikoerper-online.de)
- Sequence alignments for the functionally related molecules oncostatin M and ciliary neurotrophic factor, when mapped to the LIF structure, indicate regions of conserved structural and surface character. (ox.ac.uk)
Ligand8
- This receptor and its cognate ligand support the survival of neurons. (wikipedia.org)
- Differences in receptor-ligand interactions mediate unique biological functions. (antibody-antibodies.com)
- Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor. (antibody-antibodies.com)
- CNTF effects are mediated by a tripartite receptor complex consisting of two sigl-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular sigling moiety. (acris-antibodies.com)
- This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligand(s) is still not clearly established. (inserm.fr)
- A model for receptor binding based on the structure of the growth hormone ligand/receptor complex requires additional, novel features to account for these data. (ox.ac.uk)
- My laboratory studies the structural and functional basis of receptor/ligand interactions in systems which are relevant to human health and disease. (stanford.edu)
- Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. (stanford.edu)
Nerve Growth10
- These neurons depend on nerve growth factor (NGF) from their target areas for survival. (bioportfolio.com)
- Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic. (bioportfolio.com)
- The pharmacology of Nerve Growth Factor (NGF) and the discovery and development of tanezumab, a monoclonal anti-NGF antibody for the treatment of pain illustrate the complex and unpredictable nature o. (bioportfolio.com)
- Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium. (bioportfolio.com)
- Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. (bioportfolio.com)
- Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. (bioportfolio.com)
- To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy. (bioportfolio.com)
- NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. (bioportfolio.com)
- Nerve growth factor was significantly upregulated in surgical vs. control and in herniated vs. control discs. (biomedcentral.com)
- Davies, A.M. (1989) in Neurotrophic Factor Bioassay Using Dissociated Neurons , Nerve Growth Factor. (rndsystems.com)
IL6R8
- vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. (thermofisher.com)
- The IL6R complex is composed of two membrane glycoproteins: thelow affinity receptor and the signaltransducing component. (creativebiomart.net)
- Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. (creativebiomart.net)
- IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. (creativebiomart.net)
- IL6R also denotes the human gene encoding this subunit. (creativebiomart.net)
- Background: IL6R alpha(IL6RA) also known as CD126 or IL6R, is a type I cytokine receptor. (biobool.com)
- Interleukin 6 receptor ( IL6R ) also known as CD126 ( C luster of D ifferentiation 126 ) is a type I cytokine receptor . (wikidoc.org)
- Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). (selfdecode.com)
OSMR6
- IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor alpha (IL-31RA) and the OSM receptor beta (OSMR). (biomedcentral.com)
- This mutant still binds to the receptor subunits gp130 and OSMR. (uni.lu)
- However, we found that the SH2 domain is structurally important for cytokine receptor binding and surface expression of the OSMR. (uni.lu)
- Cloned and characterized an alternative signaling subunit conferring OSM-specific receptor activation.The receptor for OSM is a dimmer of OSMR-beta and gp130. (receptome.org)
- The receptor for OSM is a dimmer of OSMR-beta and gp130. (receptome.org)
- OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR. (antikoerper-online.de)
CNTF Receptor5
- Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral hemorrhage in rats. (acris-antibodies.com)
- Recently, we have identified two new ligands for the CNTF receptor complex. (inserm.fr)
- RESULTS: Here we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. (inserm.fr)
- CONCLUSION: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development. (inserm.fr)
- Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. (semanticscholar.org)
Cardiotrophin like cytokine1
- Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRa and activates a similar sigling pathway to that of CNTF. (acris-antibodies.com)
Inhibitory factor12
- This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. (genecards.org)
- LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. (creative-biogene.com)
- The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. (creative-biogene.com)
- Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- This graph shows the total number of publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in UAMS Profiles by year, and whether "Leukemia Inhibitory Factor Receptor alpha Subunit" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles over the past ten years. (uams.edu)
- The crystal structure of murine leukemia inhibitory factor. (ox.ac.uk)
- We have determined the structure of murine leukemia inhibitory factor (LIF) by X-ray crystallography at 2.0 A resolution. (ox.ac.uk)
- This study shows that the neurotrophic cytokine leukemia inhibitory factor (LIF) directly prevents oli. (edu.au)
- Auf www.antikoerper-online.de finden Sie aktuell 113 Leukemia Inhibitory Factor Receptor alpha (LIFR) Antikörper von 15 unterschiedlichen Herstellern. (antikoerper-online.de)
- Murphy, Halow, Royer, Hennebold: Leukemia Inhibitory Factor Is Necessary for Ovulation in Female Rhesus Macaques. (antikoerper-online.de)
- The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells. (antikoerper-online.de)
Glycoprotein2
- WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. (semanticscholar.org)
- Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250 kDa each. (embl-heidelberg.de)
LIFR2
- LIFR (LIF Receptor Alpha) is a Protein Coding gene. (genecards.org)
- It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRa).CNTF binds to CNTFRa, the latter associates with gp130 which recruits LIFR. (acris-antibodies.com)
Isoform1
- The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor. (uams.edu)
20001
- Motoneurons were selectively killed with a monoclonal antibody (IgG-192), raised against the low-affinity neurotrophin receptor p75 NTR , which is coupled to the ribosome-inactivating protein saporin ( Wiley and Kline, 2000 ). (jneurosci.org)
CNTFRalpha1
- We investigated the expression of CNTF and its specific receptor alpha ( CNTFRalpha ) in a unilateral ureteral obstruction (UUO) model. (bvsalud.org)
Induces2
- The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cy. (nih.gov)
- Cellular senescence or EGFR signaling induces interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). (springer.com)
Complexes4
- 22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. (antibody-antibodies.com)
- STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. (antibody-antibodies.com)
- Interleukins 19, 20, and 24 signal through two distinct receptor complexes. (antibody-antibodies.com)
- A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS. (umassmed.edu)
Signal transducer1
- Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. (springer.com)
Heterodimeric1
- Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. (antibody-antibodies.com)
Murine1
- Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. (wikidoc.org)
Signaling5
- 1988 ). It serves as the non-signaling alpha-receptor of the multifunctional cytokine IL-6 and is expressed in a cell-type-specific manner. (springer.com)
- Baran P, Nitz R, Grötzinger J, Scheller J, Garbers C. Minimal interleukin (IL-)6 receptor stalk composition for IL-6R shedding and IL-6 classic signaling. (springer.com)
- Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. (springer.com)
- Signaling of human ciliary neurotrophic factor (CNTF) revisited. (wikidoc.org)
- Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. (receptome.org)
Proteins2
- Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (antibody-antibodies.com)
- The anti-parallel bundles that these proteins form have an "up-up-down-down" topology, which is a relevant structure regarding the cytokine binding to their respective receptor complex. (wikidoc.org)
Gene9
- This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. (wikipedia.org)
- This gene encodes a protein that belongs to the type I cytokine receptor family. (genecards.org)
- Gene Ontology (GO) annotations related to this gene include growth factor binding and ciliary neurotrophic factor receptor activity . (genecards.org)
- Sequestration of a transcription factor in a cellular membrane and releasing it on demand is an additional layer of gene regulation that is considered a rapid mode to reprogram a gene expression casca. (bioportfolio.com)
- A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. (springer.com)
- Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. (pnas.org)
- Consequently, inhibition of p38 or MK2, deletion of MK2 or mutation of crucial amino acids within the MK2 target site or the di-leucine internalisation motif blocks receptor depletion and restores IL-6-dependent STAT activation as well as gene induction. (uni.lu)
- Analyses of more degenerated vs. less degenerated discs identified significant upregulation of well-recognized pain-related genes (bradykinin receptor B1, calcitonin gene-related peptide and catechol- 0 -methyltransferase). (biomedcentral.com)
- Immunohistochemistry was utilized to confirm the presence of calcitonin gene-related peptide, catechol-0-methyltransferase and bradykinin receptor B1 at the protein level in the human annulus. (biomedcentral.com)
Specificity2
Polypeptide2
- CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. (acris-antibodies.com)
- Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. (rndsystems.com)
Kinase3
- These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. (kegg.jp)
- We developed a renally accumulating conjugate of a TGF-beta type-I receptor kinase inhibitor (TKI) and evaluated its efficacy in vitro and in vivo. (courtfield.tk)
- 1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. (chemeurope.com)
Cytokine receptor family2
- Belongs to the type I cytokine receptor family. (abcam.com)
- Our earlier study indicated that the activation of STAT3 was essential for HN-induced neuroprotection, suggesting that the HN receptor may belong to the cytokine receptor family. (semanticscholar.org)
Soluble form1
- The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. (genecards.org)
Interleukin-11 receptor al3
- Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. (wikipedia.org)
- 1998). "Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. (wikipedia.org)
- IL-11 responsiveness is restricted to cells that express the interleukin-11 receptor alpha-chain (IL-11Ralpha) and an additional signal-transducing subunit (gp130). (receptome.org)
Expression4
- Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients. (bioportfolio.com)
- A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. (lbl.gov)
- Immunohistochemical analysis revealed disruption of rod outer segments, focal loss of the RPE integrity, and an increase in expression of endothelin receptor B in Müller cells with the two highest doses of light and fundus photography. (arvojournals.org)
- Cytokine and receptor transcript and protein expression and distribution were determined in urinary bladder after CYP-induced cystitis using quantitative, real-time polymerase chain reaction (Q-PCR), western blotting, and immunohistochemistry. (frontiersin.org)
Neurons4
- Ciliary neurotrophic factor (CNTF) is involved in the survival of a number of different neural cell types, including motor neurons. (nih.gov)
- It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. (acris-antibodies.com)
- Essential function of LIF receptor in motor neurons. (ed.ac.uk)
- Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. (rndsystems.com)
High-affinity receptor2
- LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. (creative-biogene.com)
- Because neurotrophin-3 (NT-3) is specifically produced by motoneurons and because interneurons express the NT-3 high-affinity receptor trkC, we examined the role of NT-3 in the survival of PAX2-IR interneurons. (jneurosci.org)
Tyrosine1
- 1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. (chemeurope.com)