Ciliary Neurotrophic Factor Receptor alpha Subunit
Receptor, Ciliary Neurotrophic Factor
Cell surface receptors for CILIARY NEUROTROPHIC FACTOR. They are heterotrimeric proteins formed by the association of the CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT with the LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130. Although the receptor regulates neuronal development, it is structurally similar to the cytokine receptor for INTERLEUKIN-6; (RECEPTORS, INTERLEUKIN-6).
Ciliary Neurotrophic Factor
Receptors, Nerve Growth Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Receptor, Platelet-Derived Growth Factor alpha
Brain-Derived Neurotrophic Factor
Glial Cell Line-Derived Neurotrophic Factor Receptors
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored cell surface receptors that are specific for GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTORS. They form a multi-component receptor complex with PROTO-ONCOGENE PROTEIN C-RET and regulate a variety of intracellular SIGNAL TRANSDUCTION PATHWAYS in conjunction with c-ret protein.
Nerve Growth Factors
Receptor, trkB
Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. (1/16)
PURPOSE: Ciliary neurotrophic factor (CNTF) promotes gene expression, cell survival and differentiation in various types of peripheral and central neurons, glia and nonneural cells. The level of CNTF rises rapidly upon injury to neural tissue, suggesting that CNTF exerts its cytoprotective effects after release from cells via mechanisms induced by cell injury. The purpose of this study was to determine if cells in the optic nerve head express CNTF and its tripartite receptor complex. METHODS: Well-established optic nerve head astrocytes (ONHA) and lamina cribrosa (LC) cell cultures were derived from normal human donors. Total RNA was reverse transcribed and polymerase chain reaction (PCR) amplified for mRNA detection. Cytoplasmic protein expression was determined by immunocytochemistry and Western blot analysis of the cellular lysates. Serum free medium was concentrated and used for detecting extracellular proteins. CNTF complexed with CNTFR-alpha was assayed by immunoprecipitation. RESULTS: Cells isolated from the human optic nerve head express CNTF and its tripartite receptor complex members (CNTFR-alpha, gp130, LIFR-beta). CONCLUSIONS: Taken together, these data suggest a possible neuroprotective role of CNTF in the optic nerve head. (+info)Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. (2/16)
Intrauterine nutrition status is reported to correlate with risk of cardiovascular diseases in adulthood. Either under- or overnutrition during early to mid gestation contributes to altered fetal growth and ventricular geometry. This study was designed to examine myocardial expression of ciliary neurotrophic factor receptor alpha (CNTFRalpha) and its downstream mediator signal transducer and activator of transcription 3 (STAT3) on maternal undernutrition- or overnutrition-induced changes in fetal heart weight. Multiparous ewes were fed with 50% [nutrient-restricted (NR)], 100% (control) or 150% [overfed (OF)] of National Research Council requirements from 28 to 78 days of gestation (dG; term, 148 dG). Ewes were euthanized on Day 78, and the gravid uteri and fetuses recovered. Ventricular protein expression of CNTFRalpha, STAT3, phosphorylated STAT3, insulin-like growth factor I receptor (IGF-1R), and IGF binding protein 3 (IGFBP3) were quantitated using Western blot. Plasma cortisol levels were higher in both NR and OF fetuses, whereas plasma IGF-1 levels were lower and higher in NR and OF fetuses. Fetal weights were reduced by 29.9% in NR ewes and were increased by 22.2% in fetuses from OF ewes compared to control group. Nutrient restriction did not affect fetal heart or ventricular weights, whereas overfeeding increased heart and ventricular weights. Protein expression of CNTFRalpha in fetal ventricular tissue was reduced in OF group, whereas STAT3 and phosphorylated STAT3 levels were reduced in both NR and OF groups. Expression of IGF-1R and IGFBP3 was unaffected in either NR or OF group. These data suggested that, compared with maternal undernutrition, intrauterine overfeeding during early to mid gestation is associated with increases in fetal blood concentrations of cortisol and IGF-1, in association with ventricular hypertrophy where reduced expression of CNTFRalpha and STAT3 may play a role. (+info)Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth. (3/16)
Attempts to promote neuronal survival and repair with ciliary neurotrophic factor (CNTF) have met with limited success. The variability of results obtained with CNTF may, in part, reflect the fact that some of the biological actions of the cytokine are mediated by a complex formed between CNTF and its specific receptor, CNTFRalpha, which exists in both membrane-bound and soluble forms. In this study, we compared the actions of CNTF alone and CNTF complexed with soluble CNTFRalpha (hereafter termed "Complex") on neuronal survival and growth. Although CNTF alone produced limited effects, Complex protected against glutamate-mediated excitotoxicity via gap junction-dependent and -independent mechanisms. Further examination revealed that only Complex promoted neurite outgrowth. Differential gene expression analysis revealed that, compared with CNTF alone, Complex differentially regulates several neuroprotective and neurotrophic genes. Collectively, these findings indicate that CNTF exerts more robust effects on neuronal survival and growth when applied in combination with its soluble receptor. (+info)Neuroinflammation facilitates LIF entry into brain: role of TNF. (4/16)
(+info)A putative physiological role of hypothalamic CNTF in the control of energy homeostasis. (5/16)
(+info)CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons. (6/16)
(+info)Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation. (7/16)
(+info)Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia. (8/16)
(+info)No data available that match "ciliary neurotrophic factor receptor alpha subunit"
Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese...
Ciliary neurotrophic factor receptor rs41274853 polymorphism is associated with weightlifting performance in Japanese ... Ciliary Neurotrophic Factor Receptor alpha Subunit / genetics* Actions. * Search in PubMed * Search in MeSH ... Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese ... Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese ...
Biomarkers Search
3. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell ... 6. The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and ... 4. Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and ... Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a ...
DeCS
Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.395.550.448.200] Ciliary Neurotrophic Factor Receptor alpha Subunit ... Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.484.500.200] Ciliary Neurotrophic Factor Receptor alpha Subunit ... Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.550.418.200] Ciliary Neurotrophic Factor Receptor alpha Subunit ... Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.249] Ciliary Neurotrophic Factor Receptor ...
MeSH Browser
CILIARY NEUROTROPHIC FACTOR RECEPT ALPHA SUBUNIT. Entry Term(s). CNTFRalpha Ciliary Neurotrophic Factor Receptor alpha Chain ... Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250] * Ciliary Neurotrophic Factor Receptor alpha Subunit [ ... 2007; for CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT see RECEPTOR, CILIARY NEUROTROPHIC FACTOR 2000-2006. History Note ... Ciliary Neurotrophic Factor Receptor alpha Subunit Preferred Concept UI. M0332221. Registry Number. 0. Scope Note. A ciliary ...
MeSH Browser
CILIARY NEUROTROPHIC FACTOR RECEPT ALPHA SUBUNIT. Entry Term(s). CNTFRalpha Ciliary Neurotrophic Factor Receptor alpha Chain ... Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250] * Ciliary Neurotrophic Factor Receptor alpha Subunit [ ... 2007; for CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT see RECEPTOR, CILIARY NEUROTROPHIC FACTOR 2000-2006. History Note ... Ciliary Neurotrophic Factor Receptor alpha Subunit Preferred Concept UI. M0332221. Registry Number. 0. Scope Note. A ciliary ...
Pharos : Target Details - CNTF
A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this ... The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction ... CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. The ... Ciliary Neurotrophic Factor Receptor Subunit Alpha. IDG Development Level Summary. help help. ...
Pharos : Target Details - CNTFR
Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and ... The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a ... leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be ... This gene encodes a member of the type 1 cytokine receptor family. ...
NDF-RT Code NDF-RT Name
N0000167110 Cilazapril N0000170988 Ciliary Neurotrophic Factor N0000175304 Ciliary Neurotrophic Factor Receptor alpha Subunit ... Binding Factor Alpha 1 Subunit N0000169998 Core Binding Factor Alpha 2 Subunit N0000169997 Core Binding Factor Alpha 3 Subunit ... Receptor alpha Subunit N0000175276 Interleukin-2 Receptor beta Subunit N0000175272 Interleukin-21 Receptor alpha Subunit ... Ciliary Neurotrophic Factor N0000168961 Receptor, Endothelin A N0000168960 Receptor, Endothelin B N0000168800 Receptor, EphA1 ...
MESH TREE NUMBER CHANGES - 2011 MeSH. August 17, 2010
C25.723.415.246 Ciliary Neurotrophic Factor Receptor alpha Subunit D12.776.395.550.448.200 D12.776.543.484.500.200 D12.776. ... B1.650.940.800.575.100.401.275 Glial Cell Line-Derived Neurotrophic Factor Receptors D12.776.395.550.448.400 D12.776.543.484. ... B1.650.940.800.575.100.27 alpha 1-Antitrypsin Deficiency C17.300.50 C6.552.74 C8.381.112 C16.320.60 C23.550.325.500.500 Alpha ... D12.776.543.750.51.625 Receptors, Kainic Acid D12.776.157.530.400.400.500.200 D12.776.543.550.425.500.200.200 D12.776.543.585. ...
DeCS 2007 - New terms
Ciliary Neurotrophic Factor Receptor alpha Subunit. Subunidade alfa do Receptor do Fator Neutrófico Ciliar. Subunidad alfa del ... Factor Inhibidor de Leucemia. Leukemia Inhibitory Factor Receptor alpha Subunit. Subunidade alfa de Receptor de Fator Inibidor ... Receptor Activador del Factor Nuclear kappa-B. Receptor, Interferon alpha-beta. Receptor de Interferon alfa e beta. Receptor de ... Factor Activador de Células B. B-Cell Activation Factor Receptor. Receptor do Fator Ativador de Células B. Receptor del Factor ...
Renal Toxicogenomic Response to Chronic Uranyl Nitrate Insult in Mice | Environmental Health Perspectives | Vol. 112, No. 16
ciliary neurotrophic factor receptor. NM_016673. +. Cntfr. TGATTTTTGT. 1. 10. disabled homolog 2 (Drosophila). NM_023118. +. ... ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1. NM_007505. +. Atp5a1. ... Interestingly, many ribosomal subunits and other factors involved in protein synthesis (elongation factor) were induced upon UN ... subunit IVa (Cox4a); subunit VIIIa (Cox8a); and subunit XVII assembly protein homolog (Cox 17 ). Finally, expression levels of ...
DeCS 2007 - New terms
Ciliary Neurotrophic Factor Receptor alpha Subunit. Subunidade alfa do Receptor do Fator Neutrófico Ciliar. Subunidad alfa del ... Factor Inhibidor de Leucemia. Leukemia Inhibitory Factor Receptor alpha Subunit. Subunidade alfa de Receptor de Fator Inibidor ... Receptor Activador del Factor Nuclear kappa-B. Receptor, Interferon alpha-beta. Receptor de Interferon alfa e beta. Receptor de ... Factor Activador de Células B. B-Cell Activation Factor Receptor. Receptor do Fator Ativador de Células B. Receptor del Factor ...
Neurotrophic treatment initiated during early postnatal development prevents the Alzheimer-like behavior and synaptic...
Glutamate Ionotropic Receptor NMDA Type Subunit 1 (GRIN1/NR1). Glutamate Ionotropic Receptor NMDA Type Subunit 1 (GRIN1/NR1) ... we investigated the effect of treatment during early development with a ciliary neurotrophic factor (CNTF) derived peptidergic ... Protein Kinase C alpha (PKC alpha). phospho-Protein Kinase C alpha (phospho-PKC alpha) ... Glutamate Ionotropic Receptor NMDA Type Subunit 2A (GluN2A/NR2A). Glutamate Ionotropic Receptor NMDA Type Subunit 2A (GluN2A/ ...
Emerging Strategies for the Treatment of Multiple Sclerosis
Ciliary neurotrophic factor and leukemia inhibitory factor are also being studied.. *. Retinoid X receptor:. ... an accessory alpha subunit of the high-affinity IL-2 receptor. CD25 increases the affinity of this receptor for IL-2;[47] DAC ... These cells express high levels of intermediate-affinity IL-2 receptor, which do not contain CD25; CD25 antagonism has been ... Many cytokines and their receptors have been suggested to play a role in MS. ...
Búsqueda | BVS Bolivia
Mechanistically, CLCF1 bound and activated ciliary neurotrophic factor receptor (CNTFR) and augmented signal transducer and ... Moreover, IFI27 increases hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA) catalytic ... Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/genética , Coactivador 1-alfa del Receptor ... Here, we found that cardiotrophin-like cytokine factor 1 (CLCF1) signaling led to loss of brown fat identity, which impaired ...
Vasopressin-Targets
ciliary neurotrophic factor. P51642. Cox7c. cytochrome c oxidase subunit 7C, mitochondrial P17665. ... H-2 class I histocompatibility antigen, D-B alpha chain P01895. Havcr1. hepatitis A virus cellular receptor 1 homolog. Q5QNS5. ... tumor necrosis factor receptor superfamily member 23. Q9ER63. Tomm20. mitochondrial import receptor subunit TOM20 homolog. ... tumor necrosis factor receptor superfamily, member 21. Q9EPU5. Tnfrsf23. ...
Program Publications: University of Washington: Effects-Related Biomarkers of Environmental Neurotoxic Exposures (Superfund...
Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein. ... Human signaling protein 14-3-3 zeta interacts with platelet glycoprotein Ib subunits Ib alpha and Ib beta. Blood 91(4):1295- ... Effects of ozone exposure on nuclear factor-kappa B activation and tumor necrosis factor-alpha expression in human nasal ... Nuclear factor kappa B activation by muscarinic receptors in astroglial cells: effect of ethanol. Neuroscience 120(4):841-950. ...
NIH Research Festival 2000
Is Ciliary Neurotrophic Factor (CNTF) Genotype Related to Motor Unit Physiology During Submaximal Contractions? ... Evidence of AMPA Receptor Subunit Specific Cleavage by Caspase-3 in Neurons: Physiological Modulation and Pathological ... New model of serine protease inhibitor polymerization: dimer as a fundamental unit of polymerized alpha-1-proteinase inhibitor ... Blockade of AT1 Receptors Antagonizes the Decrease in Cortical CRF1 Receptors During Isolation Stress ...
MH DELETED MN ADDED MN
Ciliary Motility Disorders C16.131.77.245.500 C16.320.184.500 Ciliary Neurotrophic Factor D12.776.641.600.212 D12.776.631.600. ... Platelet-Derived Growth Factor alpha D12.776.543.750.60.625.300 D12.776.543.750.630.625.300 Receptor, Platelet-Derived Growth ... NF-E2 Transcription Factor D12.776.930.316.750 D12.776.930.216.750 NF-E2 Transcription Factor, p45 Subunit D12.776.930.316. ... Receptor, Fibroblast Growth Factor, Type 3 D12.776.543.750.60.442 D12.776.543.750.630.442 Receptor, Fibroblast Growth Factor, ...
MH DELETED MN ADDED MN
Ciliary Motility Disorders C16.131.77.245.500 C16.320.184.500 Ciliary Neurotrophic Factor D12.776.641.600.212 D12.776.631.600. ... Platelet-Derived Growth Factor alpha D12.776.543.750.60.625.300 D12.776.543.750.630.625.300 Receptor, Platelet-Derived Growth ... NF-E2 Transcription Factor D12.776.930.316.750 D12.776.930.216.750 NF-E2 Transcription Factor, p45 Subunit D12.776.930.316. ... Receptor, Fibroblast Growth Factor, Type 3 D12.776.543.750.60.442 D12.776.543.750.630.442 Receptor, Fibroblast Growth Factor, ...
MH DELETED MN ADDED MN
Ciliary Motility Disorders C16.131.77.245.500 C16.320.184.500 Ciliary Neurotrophic Factor D12.776.641.600.212 D12.776.631.600. ... Platelet-Derived Growth Factor alpha D12.776.543.750.60.625.300 D12.776.543.750.630.625.300 Receptor, Platelet-Derived Growth ... NF-E2 Transcription Factor D12.776.930.316.750 D12.776.930.216.750 NF-E2 Transcription Factor, p45 Subunit D12.776.930.316. ... Receptor, Fibroblast Growth Factor, Type 3 D12.776.543.750.60.442 D12.776.543.750.630.442 Receptor, Fibroblast Growth Factor, ...
MH DELETED MN ADDED MN
Ciliary Motility Disorders C16.131.77.245.500 C16.320.184.500 Ciliary Neurotrophic Factor D12.776.641.600.212 D12.776.631.600. ... Platelet-Derived Growth Factor alpha D12.776.543.750.60.625.300 D12.776.543.750.630.625.300 Receptor, Platelet-Derived Growth ... NF-E2 Transcription Factor D12.776.930.316.750 D12.776.930.216.750 NF-E2 Transcription Factor, p45 Subunit D12.776.930.316. ... Receptor, Fibroblast Growth Factor, Type 3 D12.776.543.750.60.442 D12.776.543.750.630.442 Receptor, Fibroblast Growth Factor, ...
PMID- 19442392
... and the increase of brain-derived neurotrophic factor level and its receptor tyrosine kinase B expression in cerebral cortex. ... alpha-D-Rhap-(13)beta-D-Galp-(13)-alpha-D-Manp-(12)-alpha-D Manp-(1 beta-D-Glcp-(13)-alpha-D-galp-(14)-alpha- ... It was shown for the first time that P2X(2), P2X(4), P2X(5) and P2X(6) receptor subunits were expressed on the perikarya of ... Ciliary hypertrichosis and facial dysmorphia associated with diffuse, congenital hypertrichosis: Ambras syndrome?]. PMID- ...
ugt1a10 gene|ugt1a10 gene|C1421323|udp glucuronosyltransferase 1 family, polypeptide a10|gngm
... runt-related transcription factor 1 wt allele,gngm transcription factor iie, alpha subunit,transcription factor iie , alpha ... gngm t cell receptor alpha variable 3,t cell receptor alpha variable 3,C1420981,trav3,gngm t cell receptor alpha variable 2,t ... brain-derived neurotrophic factor wt allele,C1705371,brain-derived neurotrophic factor wt allele,gngm posterior ulnar recurrent ... blor region of ciliary body,region of ciliary body,C0929635,subdivision of ciliary body,blor feeling cold,feeling cold,C0234192 ...
c33c
... pps1 unfurnished achromatic aleuria cadence defluvii pr48 gelucire tytin ppr2 r440 pppa caffeoyl gudden ppox chapel subunits ... supramid bacteriochlorophyll schlatter tretin pleurectomy benzylated krt9 krt8 krt7 krt5 rabgap1 krt4 krt3 krt2 receptors krt1 ... heyl decomposition reoviruses uncoupled abcc9 abcc8 abcc6 abcc5 abcc4 genistoides abcc3 abcc2 abcc1 hexo factory factors ... hemorrhagica hedonistic rsba colombia alpk1 rsc8 rsc2 unauthorized rsal rsai perseverance rsaa acetylneuraminate rsb1 alpha ...
ugt1a10 gene|ugt1a10 gene|C1421323|udp glucuronosyltransferase 1 family, polypeptide a10|gngm
... runt-related transcription factor 1 wt allele,gngm transcription factor iie, alpha subunit,transcription factor iie , alpha ... gngm t cell receptor alpha variable 3,t cell receptor alpha variable 3,C1420981,trav3,gngm t cell receptor alpha variable 2,t ... brain-derived neurotrophic factor wt allele,C1705371,brain-derived neurotrophic factor wt allele,gngm posterior ulnar recurrent ... blor region of ciliary body,region of ciliary body,C0929635,subdivision of ciliary body,blor feeling cold,feeling cold,C0234192 ...
CNTF10
- 1. Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study. (nih.gov)
- 2. The cytokines cardiotrophin-like cytokine/cytokine-like factor-1 (CLC/CLF) and ciliary neurotrophic factor (CNTF) differ in their receptor specificities. (nih.gov)
- 4. Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression, PGE2 release and interferon-gamma-induced CD40 in murine microglia. (nih.gov)
- 5. Ciliary Neurotrophic Factor (CNTF) and Its Receptors Signal Regulate Cementoblasts Apoptosis through a Mechanism of ERK1/2 and Caspases Signaling. (nih.gov)
- 14. Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response. (nih.gov)
- 15. Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. (nih.gov)
- 16. Functional CNTF receptor alpha subunit restored by its recombinant in corneal endothelial cells in stored human donor corneas: connexin-43 upregulation. (nih.gov)
- 18. Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. (nih.gov)
- CNTF is a survival factor for various neuronal cell types. (nih.gov)
- In the present study, we investigated the effect of treatment during early development with a ciliary neurotrophic factor (CNTF) derived peptidergic compound, P021 (Ac-DGGLAG-NH2) on cognitive function and synaptic plasticity in 3xTg-AD transgenic mouse model of AD. (nih.gov)
Tripartite receptor1
- The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. (nih.gov)
Cytokine2
ELISA Kit1
- Description: A sandwich ELISA kit for detection of Protein Phosphatase 3, Regulatory Subunit 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (stemcellcharter.org)
Leukemia inhibito2
- 11. Ciliary neurotrophic factor may activate mature astrocytes via binding with the leukemia inhibitory factor receptor. (nih.gov)
- Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. (nih.gov)
Specificity1
- The alpha subunit provides the receptor specificity. (nih.gov)
Pathways3
- 3. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications. (nih.gov)
- 8. Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness. (nih.gov)
- 8)Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. (edu.in)
Neurons2
- The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. (nih.gov)
- 21)Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation. (edu.in)
Modulation2
Protein-coupled2
- 15)Cross-Linking of a DOPA-Containing Peptide Ligand into its G Protein-Coupled Receptor. (edu.in)
- Opsins have varied light absorption properties and are members of the G-PROTEIN-COUPLED RECEPTORS family. (lookformedical.com)
Antagonist1
- 14)Characterization of peptide 20-30 of follicle stimulating hormone receptor as an antagonist of receptor activity: significance of charged residues. (edu.in)
Peptide3
- These findings indicate that treatment with the neurotrophic peptide mimetic such as P021 during early development can be an effective therapeutic strategy to rescue synaptic deficit and cognitive impairment in familial AD and related tauopathies. (nih.gov)
- Following 399 pubmed articles published in the last 90 days are fetched with the text keyword [peptide AND hormone AND receptor] along with other URL parameters discussed above in the table. (edu.in)
- 2)Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy. (edu.in)
Chain1
- 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. (neobiolab.com)
Regulatory1
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protein Phosphatase 3, Regulatory Subunit 1 (PPP3R1) in Tissue homogenates and other biological fluids. (stemcellcharter.org)
Molecule1
- It is the small subunit of the MHC class I molecule. (neobiolab.com)
Activate1
- Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. (lookformedical.com)
Prevents1
- Blockade of Angiotensin II AT1 receptors prevents the sympathoadrenal response to isolation stress. (nih.gov)
Transcription1
- 6. The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway. (nih.gov)
Cell2
Signal1
- It lacks signal transducing domains which are found on the other two subunits of the receptor. (nih.gov)
Gsta41
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Glutathione S Transferase Alpha 4 (GSTa4) in samples from Serum, plasma and other biological fluids. (envite.org)
Mice1
- 27)Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. (edu.in)
Structure1
- They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. (lookformedical.com)
Activation1
- 13. The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes. (nih.gov)
Multiple1
- 11)Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. (edu.in)
Cells1
- 1)Type I Gonadotropin-Releasing Hormone Receptor (GnRH-R) Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells. (edu.in)
Neurological1
- The prevalence of perinatal risk factors (gestational age and weight, indices of neurological damage, overal sickness, respiratory failure, and retinopathy) was compared between the groups with normal and delayed RTFs. (bvsalud.org)
Content1
- Furthermore, it was evaluated how the degree of transformation is related to groundwater discharge rates, redox conditions, solid organic matter content (SOM) and microbial factors. (nih.gov)