A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
Tumors or cancer of the UVEA.
Diseases of the uvea.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
A scientific tool based on ULTRASONOGRAPHY and used not only for the observation of microstructure in metalwork but also in living tissue. In biomedical application, the acoustic propagation speed in normal and abnormal tissues can be quantified to distinguish their tissue elasticity and other properties.
The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.
The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.
The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)
The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
Diseases, dysfunctions, or disorders of or located in the iris.
The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
The dioptric adjustment of the EYE (to attain maximal sharpness of retinal imagery for an object of regard) referring to the ability, to the mechanism, or to the process. Ocular accommodation is the effecting of refractive changes by changes in the shape of the CRYSTALLINE LENS. Loosely, it refers to ocular adjustments for VISION, OCULAR at various distances. (Cline et al., Dictionary of Visual Science, 4th ed)
The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Surgical removal of a section of the iris.
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
An ionic monomeric contrast medium that was formerly used for a variety of diagnostic procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
The normal decreasing elasticity of the crystalline lens that leads to loss of accommodation.
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
The pressure of the fluids in the eye.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Examination of the angle of the anterior chamber of the eye with a specialized optical instrument (gonioscope) or a contact prism lens.
Tumors or cancer of the EYE.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.
The thin noncellular outer covering of the CRYSTALLINE LENS composed mainly of COLLAGEN TYPE IV and GLYCOSAMINOGLYCANS. It is secreted by the embryonic anterior and posterior epithelium. The embryonic posterior epithelium later disappears.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (Dorland, 28th ed)
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Diseases affecting the eye.
Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.
Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.
A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
The coagulation of tissue by an intense beam of light, including laser (LASER COAGULATION). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)

Intercellular junctions in the ciliary epithelium. (1/1033)

The fine structure of the intercellular junctions in the ciliary epithelium of rhesus monkeys and rabbits was studied with conventional electron microscopy of thin-sectioned specimens and the freeze-fracturing technique. In the rhesus monkey, a zonula occludens, zonula adhaerens, gap junctions, and desmosomes interconnect the nonpigmented cells, whereas gap junctions, puncta adhaerentia, and desmosomes connect pigmented to nonpigmented cells, and pigmented cells to one another. In the rabbit, desmosomes are absent between nonpigmented cells, and substituted for by puncta adhaerentia. The zonula occludens between nonpigmented cells greatly varies in its complexity in different regions of the cell perimeter, and in places, it may consist of very few intramembrane strands; this suggests that the ciliary epithelium is relatively leaky to ions and small molecules. Gap junctions are ubiquitous in the ciliary epithelium and particularly numerous at the interface between pigmented and nonpigmented layers; this finding indicates that the cells of the ciliary epithelium are joined in a metabolic syncytium. All gap junctions are characterized by the crystalline configuration which is typical of the uncoupled state; furthermore, in specimens fixed by immersion, they may be caused by uncoupling and take place in the time interval elapsing between interruption of the blood supply and arrival of the fixative fluid. Puncta adhaerentia resemble zonulae adhaerentes in their structural details but are macular in shape instead of encompassing the cell perimeter in a beltlike fashion. In contrast with desmosomes, the intercellular cleft of puncta adhaerentia has an irregular width and contains opaque material, but this never gives rise to the central band typical of desmosomes. On the inner aspect of the junctional membranes, there is a layer of fluffy material but no plaque of insertion for a bundle of tonofilaments. Finally, puncta adhaerentia have no representation in the interior of the plasmalemma and are intimately associated with cytoplasmic microfilaments. They probably anchor to the plasmalemma the contractile apparatus of the ciliary epithelial cells.  (+info)

Microvascular loops and networks as prognostic indicators in choroidal and ciliary body melanomas. (2/1033)

BACKGROUND: Malignant melanoma of the ciliary body and choroid of the eye is a tumor that disseminates frequently, and 50% of the diagnosed patients die within 10 years. We investigated the hypothesis that, by histopathologic analysis of the arrangement of microvessels (i.e., small blood vessels) in loops and networks, we might be able to differentiate better those patients with a favorable prognosis from those with a poor prognosis. METHODS: We conducted a population-based, retrospective cohort study of melanoma-specific and all-cause mortality for 167 consecutive patients who had an eye surgically removed because of malignant choroidal or ciliary body melanoma during the period from 1972 through 1981. Microvascular loops and networks were evaluated independently by two pathologists who were unaware of patient outcome. RESULTS: Microvascular patterns could be assessed in 134 (80%) of 167 melanoma specimens. The 10-year probability of melanoma-specific survival was worse if microvascular loops (0.45 versus 0.83; two-sided P<.0001) and networks (0.41 versus 0.72, two-sided P<.0001) were present. In multivariate Cox regression analysis of melanoma-specific survival, the hazard ratios were 1.66 (95% confidence interval [CI] = 1.19-2.30) for the presence of loops and networks as a combined three-category variable, 2.36 (95% CI = 1.37-4.05) for the presence of epithelioid cells, 1.11 (95% CI = 1.03-1.19) for the largest basal tumor diameter (evaluated as a continuous variable), and 2.14 (95% CI = 1.25-3.67) for ciliary body involvement. CONCLUSIONS: Patients with malignant uveal melanoma who have a favorable prognosis can be distinguished from those with a poor prognosis by histopathologic analysis of microvascular patterns in uveal melanoma tumor specimens.  (+info)

Hyaluronan synthase expression in bovine eyes. (3/1033)

PURPOSE: Hyaluronan (HA), a high-molecular-weight linear glycosaminoglycan, is a component of the extracellular matrix (ECM). It is expressed in eyes and plays important roles in many biologic processes, including cell migration, proliferation, and differentiation. Hyaluronan is produced by HA synthase (HAS), which has three isoforms: HAS1, HAS2, and HAS3. In this study, the HAS expression in the anterior segment of bovine eyes was investigated to determine the significance of HA in eyes. METHODS: To obtain bovine HAS probes, degenerate oligonucleotide primers, based on well-conserved amino acid sequences including the catalytic region of each HAS isoform, were used for reverse transcription-polymerase chain reaction to amplify mRNA from bovine corneal endothelial cells (BCECs). Hyaluronan synthase-1 expression in the anterior segment of bovine eyes at the protein level was investigated by immunohistochemistry. RESULTS: All three HAS isoforms were expressed in BCECs at the mRNA level. Amplified cDNA fragments of HAS1, HAS2, and HAS3 from BCECs can be aligned to human counterparts, showing similarities of 100%, 97.3%, and 100%, respectively, at the amino acid level. Hyaluronan synthase 1 was expressed at the protein level in corneal epithelium, keratocyte, corneal endothelium, conjunctival epithelium, ciliary epithelium, capillary endothelium, and trabecular meshwork. CONCLUSIONS: Hyaluronan synthase isoforms were expressed in the ocular anterior segment and are speculated to be involved in HA production in situ.  (+info)

Latrunculin-A causes mydriasis and cycloplegia in the cynomolgus monkey. (4/1033)

PURPOSE: To determine the effect of latrunculin (LAT)-A, which binds to G-actin and disassembles actin filaments, on the pupil, accommodation, and isolated ciliary muscle (CM) contraction in monkeys. METHODS: Pupil diameter (vernier calipers) and refraction (coincidence refractometry) were measured every 15 minutes from 0.75 to 3.5 hours after topical LAT-A 42 microg (approximately 10 microM in the anterior chamber [AC]). Refraction was measured every 5 minutes from 0.5 to 1.5 hours after intracameral injection of 10 microl of 50 microM LAT-A (approximately 5 microM in AC), with intramuscular infusion of 1.5 mg/kg pilocarpine HCl (PILO) during the first 15 minutes of measurements. Pupil diameter was measured at 1 and 2 hours, and refraction was measured every 5 minutes from 1 to 2 hours, after intravitreal injection of 20 microl of 1.25 mM LAT-A (approximately 10 microM in vitreous), with intramuscular infusion of 1.5 mg/kg PILO during the first 15 minutes of measurements (all after topical 2.5% phenylephrine), and contractile response of isolated CM strips, obtained <1 hour postmortem and mounted in a perfusion apparatus, to 10 microM PILO +/- LAT-A was measured at various concentrations. RESULTS: Topical LAT-A of 42 microg dilated the pupil without affecting refraction. Intracameral LAT-A of 5 microM inhibited miotic and accommodative responses to intramuscular PILO. Intravitreal LAT-A of 10 microM had no effect on accommodative or miotic responses to intramuscular PILO. LAT-A dose-dependently relaxed the PILO-contracted CM by up to 50% at 3 microM in both the longitudinal and circular vectors. CONCLUSIONS: In monkeys, LAT-A causes mydriasis and cycloplegia, perhaps related to its known ability to disrupt the actin microfilament network and consequently to affect cell contractility and adhesion. Effects of LAT-A on the iris and CM may have significant physiological and clinical implications.  (+info)

A3 adenosine receptors regulate Cl- channels of nonpigmented ciliary epithelial cells. (5/1033)

Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in isotonic suspensions with the cationic ionophore gramicidin present. The A3-selective agonist N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (IB-MECA) triggered shrinkage (apparent Kd = 55 +/- 10 nM). A3-selective antagonists blocked IB-MECA-triggered shrinkage, and A3-antagonists (MRS-1097, MRS-1191, and MRS-1523) also abolished shrinkage produced by 10 microM adenosine when all four known receptor subtypes are occupied. The A1-selective agonist N6-cyclopentyladenosine exerted a small effect at 100 nM but not at higher or lower concentrations. The A2A agonist CGS-21680 triggered shrinkage only at high concentration (3 microM), an effect blocked by MRS-1191. IB-MECA increased intracellular Ca2+ in HCE cells and also stimulated short-circuit current across rabbit ciliary epithelium. A3 message was detected in both HCE cells and rabbit ciliary processes using RT-PCR. We conclude that human HCE cells and rabbit ciliary processes possess A3 receptors and that adenosine can activate Cl- channels in NPE cells by stimulating these A3 receptors.  (+info)

Higher proportions of type C than of types A and B natriuretic peptide receptors exist in the rat ciliary body. (6/1033)

We investigate the interaction of atrial natriuretic peptide (ANP) brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) with their receptors (NPRA, NPRB and NPRC), as well as the proportion and localization of those receptors in the rat ciliary body. Binding assays and affinity cross-linking experiments demonstrated the presence of the NPRC receptor type. However, the three natriuretic peptides stimulate the guanylate cyclase activity in the ciliary body membranes suggesting the presence of the NPRA and NPRB receptor type. Microautoradiographic data show that the NPRs are localized in the whole ciliary body. Our results indicated that NPRC is the most prominent receptor type in this tissue.  (+info)

Dendritic cells and macrophages in the uveal tract of the normal mouse eye. (7/1033)

BACKGROUND/AIMS: Dendritic cells (DC) and macrophages are components of the immune cell populations in the uveal tract whose density, distribution, turnover, and function may play a role in the maintenance of immunological homeostasis in the eye. Little is known of these cells in the mouse eye despite this being the predominant experimental model in many studies of ocular immune responses and immunoinflammatory mediated eye diseases. The aim of the present study was to obtain further immunophenotypic data on resident tissue macrophages and DC populations in the mouse uveal tract. METHODS: Pieces of iris, ciliary body, and choroid dissected from perfusion fixed BALB/c mice were incubated whole in a variety of anti-macrophage and DC monoclonal antibodies (mAbs). Labelled cells were visualised using either single or double immunoperoxidase techniques. RESULTS: Quantitative analysis and double immunolabelling revealed that 80% of F4/80(+) cells (a mAb that recognises both DC and macrophages) in the iris are macrophages (SER4(+)). The iris contained a network of Ia+ cells (412 (SD 130) cells/mm2) of which two thirds appear to be DC. A similar pattern was observed in the ciliary body and choroid. Only a few DC in the uveal tract were very weakly reactive for mAbs which recognise B7-1 (CD80), B7-2 (CD86), beta2 integrin (mAb N418), and multivesicular bodies associated with antigen presentation (mAb M342). CONCLUSIONS: The present study reveals that the mouse uveal tract, like the rat, contains rich networks of DC and resident tissue macrophages. The networks of resident tissue macrophages in the mouse uveal tract closely resemble similar networks in non-ocular tissues. The phenotype of uveal tract DC suggests they are in the "immature" phase of their life cycle, similar to Langerhans cells of the skin, thus implying their role in situ within the eye is antigen capture and not antigen presentation.  (+info)

Age-related changes in human ciliary muscle and lens: a magnetic resonance imaging study. (8/1033)

PURPOSE: To use high-resolution magnetic resonance (MR) images of the eye to directly measure the relationship between ciliary muscle contraction and lens response with advancing age. METHODS: A General Electric, 1.5-Tesla MR imager and a custom-designed eye imaging coil were used to collect high-resolution MR images from 25 subjects, 22 through 83 years of age. A nonmagnetic binocular stimulus apparatus was used to induce both relaxed accommodation (0.1 diopter [D]) and strong accommodative effort (8.0 D). Measurements of the ciliary muscle ring diameter (based on the inner apex), lens equatorial diameter, and lens thickness were derived from the MR images. RESULTS: Muscle contraction is present in all subjects and reduces only slightly with advancing age. A decrease in the diameter of the unaccommodated ciliary muscle ring was highly correlated with advancing age. Lens equatorial diameter does not correlate with age for either accommodative state. Although unaccommodated lens thickness (i.e., lens minor axis length) increases with age, the thickness of the lens under accommodative effort is only modestly age-dependent. CONCLUSIONS: Ciliary muscle contractile activity remains active in all subjects. A decrease in the unaccommodated ciliary muscle diameter, along with the previously noted increase in lens thickness (the "lens paradox"), demonstrates the greatest correlation with advancing age. These results support the theory that presbyopia is actually the loss in ability to disaccommodate due to increases in lens thickness, the inward movement of the ciliary ring, or both.  (+info)

TY - JOUR. T1 - Molecular identification of functional water channel protein in cultured human nonpigmented ciliary epithelial cells. AU - Han, Zhiqiang. AU - Yang, Junjie. AU - Wax, Martin B.. AU - Patil, Rajkumar V.. N1 - Funding Information: Supported by NIH grants EY10423 (RVP), EY06810 (MBW), Core Grant, EY02687, and Unrestricted grant from Research to Prevent Blindness, Inc. RVP is a Research to Prevent Blindness Olga Keith Wiess Scholar.. PY - 2000/3. Y1 - 2000/3. N2 - Purpose. Water channel proteins are important pathways for water movements across cell membranes, including those in the ciliary epithelium, which is the major site of aqueous humor secretion. In this study, we aimed to demonstrate the expression of functionally active aquaporin-1 (AQP1) water channels in cultured human ciliary epithelial cells. Methods. Poly A+ RNA was isolated from cell cultures of Simian Virus 40 (SV-40) transformed human nonpigmented ciliary epithelium (NPE) subjected to RT-PCR reaction using primers ...
In the current study, our results demonstrated that the IκB/NF-κB signaling pathway was involved in the expression and activation of MMP-2 in human ciliary muscle cells. Downregulation of IκBα by siRNA resulted in significant translocation of NF-κBp65 from the cytoplasm to the nucleus after 24 h to 72 h. The secretion of MMP-2 increased as well as the activation from pro-MMP-2 to active-MMP-2. In addition, the expression of MT1-MMP increased while the expression of TIMP-2 reduced both in mRNA and protein levels. It is implied from these results that NF-κB is an important transcriptional factor involved in the control of uveoscleral outflow through the promotion of MMP-2 expression. It has been reported that NF-κB is involved in various activities and plays a key role in multiple biological processes including chemical stress, physical stress, physiologic stress, receptor ligands, proinflammatory cytokines, and apoptosis. At the same time, there are also multiple and complex signal ...
Description of disease Ciliary body melanoma. Treatment Ciliary body melanoma. Symptoms and causes Ciliary body melanoma Prophylaxis Ciliary body melanoma
Read A Large-Conductance Chloride Channel in Pigmented Ciliary Epithelial Cells Activated by GTPγS, The Journal of Membrane Biology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
TY - JOUR. T1 - Endoscopic cyclophotocoagulation using iris hooks versus viscoelastic devices. AU - Kahook, Malik Y.. AU - Schuman, Joel S.. AU - Noecker, Robert J.. PY - 2007. Y1 - 2007. N2 - Endoscopic cyclophotocoagulation utilizes a diode laser to ablate ciliary body epithelium, resulting in decreased intraocular pressure. Viscoelastic devices are often used to elevate the iris for improved exposure and efficient treatment of targeted tissue. Occasionally, early postoperative intraocular pressure spikes may occur due to retained viscoelastic material. Iris hooks may provide a safe alternative for elevation of the iris duting endoscopic cyclophotocoagulation treatment and may be particularly advantageous in cases of aphakia or posterior capsule compromise in which viscoelastic removal is made more difficult.. AB - Endoscopic cyclophotocoagulation utilizes a diode laser to ablate ciliary body epithelium, resulting in decreased intraocular pressure. Viscoelastic devices are often used to ...
TY - JOUR. T1 - Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. AU - Brito, Beatriz E.. AU - Zamora, David O.. AU - Bonnah, Robert A.. AU - Pan, Yuzhen. AU - Planck, Stephen R.. AU - Rosenbaum, James T.. PY - 2004/8/1. Y1 - 2004/8/1. N2 - We investigated the expression of the functional endotoxin receptor proteins Toll-like receptor-4 and CD14 in human eyes. Toll-like receptor-4 and CD14 proteins were detected by immunohistochemical analysis of sections of whole human eyes embedded in paraffin with monoclonal antibodies against human toll-like receptor-4 (HTA-125), human CD14 (RPA-M1), or as a control, an irrelevant mouse IgG1k (MOPC-21). Incubation of explants with a neutralizing anti-toll-like receptor-4 monoclonal antibody was used to determine if lipopolysaccharide stimulation of tumor necrosis factor or interleukin-6 secretion was dependent on Toll-like receptor-4 activity. Reverse transcription-polymerase chain reaction was used to ...
Fig. 8. Hypothetical model of the involvement of NaDC3, OAT1, OAT3, MRP2, and MRP4 in transepithelial OA transport across the ciliary body, aqueous humor (AH)-to-blood (choroid). Uptake of OA across the basolateral membrane of nonpigmented cells occurs via a tertiary active transport process involving Na,K-ATPase (1°; NKA), NaDC3 (2°), and OAT1 and/or OAT3 (3°). OAs are then pumped into the interstitium by MRP2, which localizes to apical membranes of nonpigmented cells. Alternatively, OAs diffuse through gap junctions into pigmented cells and are pumped into the interstitium by MRP4. MRP2 and MRP4 are ATP-dependent efflux transporters. mRNA for NaDC3 has been detected in nonpigmented epithelial cells (George et al., 2004), but its subcellular localization is unknown. It is placed in the basolateral membrane of nonpigmented cells in this model given that it trafficks to basolateral membranes of other epithelial cells. Other OA transporters may also contribute to transepithelial OA secretion. ...
Dorzolamide is a sulfonamide and a highly specific carbonic anhydrase II (CA-II) inhibitor, which is the main CA isoenzyme involved in aqueous humor secretion. Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Dorzolamide also accumulates in red blood cells as a result of CA-II binding, as CA-II is found predominantly in erythrocytes. However, sufficient CA-II activity remains so that adverse effects due to systemic CA inhibition are not observed ...
Cytoplasmic pH was measured by imaging microscopy using the pH-sensitive dye BCECF (2′,7′-bis(2-carboxyl)-5(6)-carboxyfluorescein-acetoxyethyl ester). To load the cells with BCECF, NPE cells grown to semiconfluence on a 35-mm plastic dish (Corning Costar, Corning, NY) were incubated for 10 minutes with BCECF-AM (5.0 μM) as described earlier. 24 Then, the cells were washed five times with the Krebs solution and incubated for another 10 minutes in Krebs solution to allow de-esterification of the dye. De-esterification transforms BCECF-AM (the ester form) to membrane-impermeable BCECF (acid form), which is trapped in the cytoplasm. The cells were then washed again several times to remove any traces of external dye. The dish containing the cells was then placed in a temperature-controlled perfusion microincubator (PDMI-2; Harvard Biosciences, Holliston, MA) on the stage of an upright epifluorescence microscope (Eclipse; Nikon, Tokyo, Japan) where the preparation was superfused (3.0 mL · ...
Ciliary body medulloepithelioma is an intraocular neoplasm derived from the primitive ciliary body medullary epithelium, which forms the non-pigmented ciliary body epithelium. First described in histologic detail by Verhoeff in 1904, this unusual lesion was named teratoneuroma [1]. Fuchs in 1908 coined the term of diktyoma [1]. However, Grinker later on identified the cellular origin of the tumor by naming it medullopithelioma in 1931 [2]. Without any hereditary or racial predisposition, this childhood tumor is the second most common intraocular primary malignancy, following primary intraocular retinoblastoma [3]. Its exact population based incidence is undetermined because it is a very rare neoplasm [4]. Based on the incidence of retinoblastoma, which has been reported to be around 4.1 per million in the United States, we can infer that the incidence of medulloepithelioma is significantly lower [5]. The average onset of this disease is 4 years of age, with diagnosis typically in the first ...
Synonyms for Ciliary processes in Free Thesaurus. Antonyms for Ciliary processes. 5 words related to ciliary body: eye, oculus, optic, tissue layer, membrane. What are synonyms for Ciliary processes?
To assess the biotransformational capability of ocular tissues in the rabbit, representative phase II enzymes were assayed in five tissues from the eye, and in the liver, kidney, and intestine. Within the eye, the iris/ciliary body exhibited the highest glutathione S-transferase activity, whereas the cornea possessed the highest specific activities for N-acetyl-, sulfo-, and UDP-glucuronosyl-transferases. Cornea, iris/ciliary body, choroid, and retina exhibited significant activities of p-aminobenzoic acid N-acetyltransferase, 2-naphthol sulfotransferase, and 1-chloro-2,4-dinitrobenzene glutathione S-transferase. Despite its size and protein content, lens displayed little or no biotransformational activity. Only the iris/ciliary body conjugated sulfobromophthalein with glutathione. UDP-glucuronsyltransferase activity varied depending on tested substrates and tissues. When compared to liver, kidney, or intestine, N-acetyltransferase activity in the iris/ciliary body nearly matched the rate ...
Posterior ciliary muscle fibers were thicker in children with myopia, while the apical region of the ciliary muscle was thicker in hyperopes, according to a study.This is likely the first evidence suggesting that accommodative workload is associated with a specific region of the muscle, which is largely comprised of circular and some radial fibers, the study authors said. Full Story →. ...
Glaucoma is a serious disease associated with increased intraocular pressure which often leads to blindness. One of the ways to treat glaucoma is to reduce aqueous humour secretion in the ciliary body of the eye by suppressing (inhibiting) activity of special enzymes - carbonic anhydrases. Russian scientists from RUDN University have designed new compounds that can effectively reduce intraocular pressure by isoform selective inhibiting human carbonic anhydrase. The results of the study were published in the prestigious Bioorganic Chemistry journal.
Pvrl3 encodes a cell adhesion protein that is required for the formation of cell-cell junctions in neurons and other cell types (Takai et al., 2003b). Mutations in this gene are associated with congenital ocular defects in the lens and ciliary body in humans (Lachke et al., 2012). Pvrl3-deficient mice have microphthalmia and defects in cell adhesion between the pigmented and non-pigmented ciliary epithelial cells of the eye (Inagaki et al., 2005). Lamination is normal in the Pvrl3-deficient mouse retina, and it has been proposed that the microphthalmia is a secondary effect of perturbations in the formation of vitreal humor due to the defects in the ciliary epithelium (Inagaki et al., 2005). Cep192 orchestrates a signaling cascade that is required for centrosome maturation and bipolar spindle assembly during mitosis (Kim and Dynlacht, 2013). Downregulation of Cep192 in Brg1-deficient retinae might perturb the coordination of interkinetic nuclear migration and the timing of S-phase and M-phase in ...
Treatment for glaucoma is directed at restoring both vision and comfort. This requires an accurate assessment of the extent and duration of the pressure elevation. In eyes which have the potential for return of functional vision (no globe enlargement, duration less than one week), immediate medical therapy is used to initially reduce the pressure. This is followed by a choice of surgical options to attempt to permanently normalize the pressure. Medical management is rarely successful long-term due to recurrent pressure elevation and drug toxicity.. The diode laser is used to treat glaucoma through photocoagulation of the ciliary body. A 1 mm probe is applied to the sclera 2-2.5 mm posterior to the limbus to deliver 2.5-3.5 joules (2.5 mwatts for 1000-1400 msec) of energy to the ciliary body over 20-30 sites. This results in localized destruction of the secretory epithelium of the ciliary body thus reducing aqueous humor production. There is also some increase in extrascleral outflow of aqueous ...
Purpose : MicroRNAs (miRNAs) are small, noncoding strands of RNA that negatively regulate post-transcriptional gene expression. Since miRNAs have been associated with many eye diseases, many studies have tried to profile the mammalian ocular miRNAs using microarray and realtime PCR. Our study aims to profile ocular miRNA expression in normal human eye tissue using miRNA-Seq. Methods : Total RNAs were extracted from normal human ciliary body (CB) (n=2), cornea (n=2), retina (n=2), and trabecular meshwork (TM) (n=4) samples using mirVana total RNA isolation kit from Life Technologies. We used 1 µg RNA from each sample to prepare sequencing library with Illumina TruSeq Small RNA Library Prep kit with sample-specific indexes. Pooled libraries were sequenced using Illumina MiSeq. Generated sequence reads were trimmed and aligned against human reference database using Bowtie software. Only exact matches to known mature miRNA sequences were counted. The resulting miRNA profile was analyzed and ...
The owners noticed an increasing red mass behind the iris during the 4 months prior to the examination. The tumor originated from the ciliary body epithelium and extended posteriorly, detaching the retina.. ...
Transscleral cyclophotocoagulation with diode laser is a surgical procedure. The laser is applied to the area of the eye that produces aqueous humour (the ciliary body) to decrease the production of liquid and, therefore, intraocular pressure.
Synonyms for ciliary muscle in Free Thesaurus. Antonyms for ciliary muscle. 3 synonyms for ciliary: cilial, ciliate, ciliate. What are synonyms for ciliary muscle?
For advanced or aggressive cases of open-angle glaucoma, the patient may be advised to undergo a Laser Cyclophotocoagulation. This procedure is usually conducted when other treatments have proven unsuccessful. This surgery targets the ciliary body within the eye-the part of the eye responsible for production of fluid. If the ciliary body is not functioning properly, the pressure in the frontal portion of the eye will not drain, resulting in glaucoma. An ophthalmologist cuts part of the ciliary body so that it will make less fluid and reduce eye pressure. This procedure is performed under local anesthesia and is followed up with exams to monitor eye pressure and inflammation.. ...
I am working on the first section of my book of poems possibly titled On My Last Nerve. It is Ciliary Body, and this is the first poem in that section. It is about my fears of Multiple Sclerosis, which took my mothers life --- and is associated with a particular memory of visiting an eye doctor in hopes he could tell me whether my optic nerve had any signs of sclera ...
ICD-10 C69.40 is malignant neoplasm of unspecified ciliary body (C6940). This code is grouped under diagnosis codes for neoplasms.
ECP is a new technique that reduces the amount of fluid (aqueous humor) produced in the eye and thus lowers pressure within the eye (intraocular pressure or IOP). This can help patients suffering from glaucoma, a disease where excess fluid puts pressure on the optic nerve and damages vision.. ECP is often performed at the same time as cataract surgery for patients who suffer from both cataracts and glaucoma. Recent studies show that patients who undergo the combined ECP/cataract surgery need fewer glaucoma medications over the long term.. During an ECP procedure, the ophthalmologist inserts a tiny probe with a fiber optic light at the tip into the part of the eye that produces fluid, known as the ciliary body or ciliary process. Laser energy then damages some of these cells so they stop producing fluid. The result is a lower, healthier pressure within the eye. Many patients who undergo ECP will sometimes no longer need eyedrops or other glaucoma medications after treatment.. Dr. Allaman has been ...
Other iris/ciliary body signature genes have known roles in myosin phosphorylation (PPP1R12B), sarcolemmal calcium homeostasis (CASQ2), and ATP availability (CKMT2), all of which may contribute to ciliary body/trabecular meshwork contractility ...
Ciliary muscle - Ciliary muscle - Musculus ciliaris - IMAIOS. We provides discount Herbal Sports nutritionals. Muscle Advance Weight Gainer with 810 Calories, 52g Protein, 94g Carbs Per-Serving.
Meshed parts were then imported into LS-DYNA (LSTC, Livermore, CA) following assembly using LSPREPOST (LSTC). Contacts were defined for each part-to-part contact as follows. The lens to zonules, zonules to ciliary body, ciliary body to sclera, and sclera to cornea were attached sequentially. This contact type ties the nodes and outer segments of the two parts together at the contact interface so that the displacements of adjacent tissues must be equal. Failure of the contact was not modeled at these attachments. Contacts between the vitreous and all other structures, retina and all other structures, and aqueous and all other structures were modeled allowing a failure criterion to be defined at the contact junction. Due to a lack of knowledge of the specific failure thresholds for these junctions in the physical eye, the failure values were set to a level thought to be above reported physiological failure levels of the tissues, with the exception of the retina-to-sclera junction; this contact ...
Cyclophotocoagulation - One of the ways to treat glaucoma is to decrease the amount of fluid production in the eye from the cells that make the fluid. Ciliary body treatments use either a cryoprobe (a freezing probe) or a laser to treat cells that make the fluid in the eye. These procedures cause the cells to decrease their usual production. The G-Probe is a non-invasive fiber-optic laser handpiece specially designed for the selective ablation of ciliary processes. G-Probe treatment is repeatable and is performed in the operating room. ...
if defined key_si3 hicth(:,:) = 0._wp ; hicth(1:jpi,1:jpj) = hm_i (:,:) ui_e(:,:) = 0._wp ; ui_e(1:jpi, 1:jpj) = u_ice(:,:) vi_e(:,:) = 0._wp ; vi_e(1:jpi, 1:jpj) = v_ice(:,:) ! ! compute ssh slope using ssh_lead if embedded zssh_lead_m(:,:) = ice_var_sshdyn(ssh_m, snwice_mass, snwice_mass_b) ssh_e(:,:) = 0._wp ; ssh_e(1:jpi, 1:jpj) = zssh_lead_m(:,:) * tmask(:,:,1) ! CALL lbc_lnk_icb( icbutl, hicth, T, +1._wp, 1, 1 ) CALL lbc_lnk_icb( icbutl, ui_e , U, -1._wp, 1, 1 ) CALL lbc_lnk_icb( icbutl, vi_e , V, -1._wp, 1, 1 ) #else ssh_e(:,:) = 0._wp ; ssh_e(1:jpi, 1:jpj) = ssh_m(:,:) * tmask(:,:,1) #endif CALL lbc_lnk_icb( icbutl, ssh_e, T, +1._wp, 1, 1 ) ...
Protein name: OATP1A2 Aliases: N/D Substrates: bile salts, organic anions and cations Transport type: N/D Tissue and cellular expression: brain (endothelial cells), kidney, intestine, liver (cholangiocytes), eye (ciliary body) Subcellular expression: apical (kidney, intestine), ciliary body (eye) Disease: N/D Locus: 12p12 Sequence ID: NP_066580.1, NM_021094.3 NP_602307.1, NM_134431.3 Gene ID: 6579 ...
Figure 3. Agarose gel analysis of total RNA and RT-PCR products. A: RNA isolated from RNAlaterTM preserved human ocular tissues using either RNAqueous-4PCR (Lanes 1-5) or ToTALLY RNA (Lanes 6-9) on an EtBr-stained denaturing agarose gel. Each lane contains 1 mg of RNA. B: RNA quality was determined by RT-PCR amplification of the house-keeping gene GAPDH. RNA examined was from the following ocular tissues: iris (lane 1), ciliary body (lane 2), choroid/RPE (lane 3), trabecular meshwork (lane 4), retina (lane 5), lens (lane 6), cornea (lane 7), optic nerve (lane 8), and optic nerve head (lane 9).. ...
Weve been instructed that there are several surgical treatments that may prolong vision and help with fluid and pressure reduction. We are still in the process of researching these procedures to see what we want to do. Currently, we are at a point where we could opt to treat her bad eye with one of these surgical procedures, but have decided not to due to her loss in vision. One option is to place a shunt in her eye that would help drain fluid, which has an average success rate of 25% after 1 year and of course a risk of blindness from the surgery. Additionally, the shunt could cause irritation and other issues. This procedure runs around $3,500. Another option we are looking into is Endoscopic cyclophotocoagulation (ECPC), which also comes with risks such as cataracts, blindness, and retinal detachment. With this procedure, the lens is removed and small incision is made. With a laser, they blast the ciliary bodies that produce the aqueous humor (the fluid). There is another laser surgery where ...
Ultrasound microscopy on the left eye shows the swelling of the ciliary body at 1 month post-trauma. The chamber angle shows normal structure and diffuse thicke
Axial section through an eye of 25 weeks fetus.C = cornea; AC = anterior chamber; PC = posterior chamber; L = lens; M = macula; HV = hyaloid vessels; CB = ciliary bodies. ...
A 5-times enlarged model of the eyeball is sagitally sectioned to show the following: cornea, iris, pupil, lens, ciliary bodies, retina and vasculature, optic nerve, rectus muscles and more. Dissects into 2 parts. Removable from stand Made of SOMSO-Plast. Size: 6 x 6 x 9. Somso Modelle.
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Looking for online definition of ciliary nerve, short in the Medical Dictionary? ciliary nerve, short explanation free. What is ciliary nerve, short? Meaning of ciliary nerve, short medical term. What does ciliary nerve, short mean?
TY - JOUR. T1 - Relationship between ciliary blood flow and aqueous production. T2 - Does it play a role in glaucoma therapy?. AU - Kiel, Jeffrey W.. AU - Reitsamer, Herbert A.. PY - 2006/4/1. Y1 - 2006/4/1. N2 - This review will summarize the authors recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.. AB - This review will summarize the authors recent studies of the relationship between ciliary blood ...
This study provides a detailed description of immunolocalization of two oxygen-binding proteins, neuroglobin (Ngb) and cytoglobin (Cygb), in the anterior segment of healthy human and canine eyes. Specific antibodies against Ngb and Cygb were used to examine their distribution patterns in anterior segment structures including the cornea, iris, trabecular meshwork, canal of Schlemm, ciliary body, and lens. Patterns of immunoreactivity (IR) were imaged with confocal scanning laser and conventional microscopy. Analysis of sectioned human and canine eyes showed Ngb and Cygb IR in the corneal epithelium and endothelium. In the iris, Ngb and Cygb IR was localized to the anterior border and the stroma, iridal sphincter, and dilator muscle. In the iridocorneal angle, Ngb and Cygb were detected in endothelial cells of the trabecular meshwork and canal of Schlemm in human. In the ciliary body, Ngb and Cygb IR was localized to the non-pigmented ciliary epithelium of the pars plana and pars plicata and in ciliary
24 cases of Schwartz Matsuo syndrome are described in the literature from 1970 until now. Usually the patients are young men with post-traumatic rhegmatogenous retinal detachment associated to oral dialyses or tears in the nonpigmented epithelium of the ciliary body with the signs completely relieved after retinal surgeries. Our patient presented with a non post-traumatic retinal detachment without oral dialyses or tears in the nonpigmented epithelium of the ciliary body. The signs disappeared after surgery but the retinal detachment recurred twice and at the end it was associated to a macular hole.. Back to previous ...
AIM: To investigate the infiltration and activation of lymphocyte in iris-ciliary body and anterior chamber after allogenic penetrating keratoplasty (PK), for further revealing the role of iris-ciliary body in corneal allograft immune rejection. METHODS: In the mice models of PK, BALB/C mice received orthotopic isografts (n =35) or C57BL/6 donor allografts (n =25). Grafts were examined daily for 3 weeks by slit-lamp microscopy and scored for opacity. The infiltration of CD4(+) T lymphocyte in iris-ciliary body and anterior chamber was examined by immunohistology and the mRNA of CD80 and CD86 in both cornea graft and iris-ciliary body by RT-PCR was analyzed in allograft recipient at days 3, 6, 10 and the day when graft rejection occurred. Isograft recipients were examined as control at the corresponding time points. Transmission electron microscope was used to study the ultrastructure, especially cell infiltration, of iris-cilary body and corneal graft at day 3, 7 and the day when rejection ...
TY - JOUR. T1 - Does Dopamine Act at Dopamine Receptors in the Ciliary Epithelia?. AU - Wax, M. B.. PY - 1993/3/1. Y1 - 1993/3/1. UR - http://www.scopus.com/inward/record.url?scp=0027526563&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027526563&partnerID=8YFLogxK. U2 - 10.1006/exer.1993.1048. DO - 10.1006/exer.1993.1048. M3 - Editorial. C2 - 8472793. AN - SCOPUS:0027526563. VL - 56. SP - 371. EP - 373. JO - Experimental Eye Research. JF - Experimental Eye Research. SN - 0014-4835. IS - 3. ER - ...
Diktyoma, or ciliary body medulloepithelioma, or teratoneuroma, is a rare tumor arising from primitive medullary epithelium in the ciliary body of the eye. Almost all diktyomas arise in the ciliary body, although, rarely, they may arise from the optic nerve head or retina. The name diktyoma comes from its characteristic findings on histology. Diktyoma is classified into teratoid and nonteratoid types, based on heteroplastic tissue in the former. Each type may be sub-classified as benign or malignant based on histology. Based on histology, the tumor is classified as malignant if it contains poorly differentiated neuroblasts, nuclear pleomorphism, markedly abnormal mitotic activity, sarcomatous components, or invasion into the uvea, cornea, or sclera. Most diktyomas are malignant. The most common symptoms of diktyoma are vision loss and pain, while the most common signs are leukocoria and presence of a mass in the iris or ciliary body. Other signs and symptoms include lens subluxation, glaucoma, ...
Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.
DR KAHOOK: Hello, everybody. I am going to put up my screen here, so that you can see my slide deck that were gonna go over. As you can see, the title here is cyclophotocoagulation: Technology and patient selection. My name is Malik Kahook. I am professor of ophthalmology at the University of Colorado, and Im currently sitting in an airport lounge. So Im going to keep my voice to this level, and hopefully there wont be too much surrounding noise during this. Im gonna try to get this done with enough time for question and answer afterwards. You know where the question tab is, so please take a look at that and send in your questions, so that Lawrence can tabulate the questions and we can go over them with as much time as we have left. These are my financial disclosures, none of which are relevant to this talk. And heres a simple outline. Were gonna talk about cyclophotocoagulation in the traditional sense. That is transscleral. But also covering endoscopic, because more and more were doing ...
Very well treated by Dr. Finger. He explained everything I needed to know about my issue with detail and attention, putting me at ease and giving me confidence to handle this problem for the rest of my life ...
NF-κB is a key regulator of inflammatory response and is frequently activated in human cancer including the undifferentiated nasopharyngeal carcinoma (NPC), which is common in Southern China including Hong Kong. Activation of NF-κB is common in NPC and may contribute to NPC development. The role of NF-κB activation in immortalization of nasopharyngeal epithelial (NPE) cells, which may represent an early event in NPC pathogenesis, is unknown. Examination of NF-κB activation in immortalization of NPE cells is of particular interest as the site of NPC is often heavily infiltrated with inflammatory cellular components. We found that constitutive activation of NF-κB signaling is a common phenotype in telomerase-immortalized NPE cell lines. Our results suggest that NF-κB activation promotes the growth of telomerase-immortalized NPE cells, and suppression of NF-κB activity inhibits their proliferation. Furthermore, we observed upregulation of c-Myc, IL-6 and Bmi-1 in our immortalized NPE cells. ...
Parthasarathy, A., Aung, T., Oen, F.T.S., Tan, D.T.H. (2008). Endoscopic cyclophotocoagulation for the management of advanced glaucoma after osteo-odonto-keratoprosthesis surgery [3]. Clinical and Experimental Ophthalmology 36 (1) : 93-94. [email protected] Repository. https://doi.org/10.1111/j.1442-9071.2007.01657. ...
Steven Vold, MD, invites Robert Noecker, MD, MBA, to share his thoughts on recent advances in endoscopic cyclophotocoagulation (ECP). Dr. Noecker explains how this procedure enhances surgery both in the OR and in an office-based setting. He shares pe…
Uvea. The middle layer. The front uvea includes the iris and ciliary body, while the back uvea is the choroid, which is rich in blood vessels and pigmented cells. The iris is the coloured part of your eye with the pupil in the centre, which changes size to let more or less light into your eye. The ciliary body is a muscle behind the iris that changes the size of your pupil and the shape of your lens to help your eye focus ...
• In spite of the fact that balloon cell change has been recognized ophthalmoscopically and histologically in certain posterior choroidal melanomas, the nature
Diagnosis Code H21.301 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Free, official info about 2015 ICD-9-CM diagnosis code 364.4. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
Free, official coding info for 2018 ICD-10-CM H22 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Diagnosis Code H22 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Age-related macular degeneration (ARMD) is the leading cause of vision loss in the western world. Non-neovascular (dry) ARMD is characterized by...
Accommodation - changing the focal length of the lens in order to focus on an object. Amacrine cells - interneurons located in the retina Anterior chamber - Fluid-filled area located between the iris and cornea. Choroid - The middle coat of the eye, located between the sclera and retina, which contains blood vessels that nourish the structures in the eye. Ciliary body - Structure located behind the iris which secretes aqueous humour. It contains ciliary muscle, which is involved with changing the shape of the lens for accommodation. Cornea- a transparent section in the anterior of the eye which acts as a window over the pupils, and is involved with refracting light as it enters the eye. Downstream genes - genes that are activated by other upstream genes. Ectoderm - outermost layer of germ cells in an early embryo. Endoderm - innermost layer of germ cells in an early embryo. Extraocular muscles - Muscles that control the movement of the eyeball. Glial cells - non-neuronal cells that provide ...
Get an answer for This is fine nonpigmented hair that covers the body of the fetus.A) VellusB) PapillaC) AlopeciaD) Hair folliclesE) Lanugo and find homework help for other Biology questions at eNotes
Eye with uvea - Mayo Clinic Eye with uvea Print Sections Eye with uvea The uvea is a layer of tissue beneath the white of the eye (sclera). It has three parts: the iris, which is the colored part of the eye; the ciliary body, which secretes the trans.... ...
EpiCast Report: Uveitis - Epidemiology Forecast to 2026Uveitis is the inflammation of the uveal tract (iris, ciliary body, and choroid), but can also cause the inflammation of nearby tissues, such
Uveitis is defined as inflammation of the uveal tract,the anatomy of which includes the iris, ciliary body, and choroid. See the image below.
Uveitis is defined as inflammation of the uveal tract,the anatomy of which includes the iris, ciliary body, and choroid. See the image below.
Uveitis - Uveitis refers to the inflammation of the eyes middle layer, which consists of the iris, ciliary body, and choroid. Several fungal, viral, or bacterial
Uveitis is an inflammatory process affecting the iris, the ciliary body, the choroid layer or all or part of these structures of the eye. Significant vision loss can occur in up to 35% of children and adults with uveitis and total blindness as a result of uveitis accounts for 10% to 15% of all cases. Midatech is using its Q-Sphera sustained release technology to develop OpsiSporin, a sustained release cyclosporine, for use in uveitis. Current treatments for uveitis such as systemic or local immunosuppressants and corticosteroids have limited efficacy and very poor side-effect profile, has yet to be brought to market - this is the objective of OpsiSporin.. This project is anticipated to reach clinical stage in the second half of 2018, but the intention is to partner this program globally.. ...
Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome an …
Cause contraction of the ciliary muscle which pulls the scleral spur to tighten the trabecular meshwork, increasing the outflow of aqueous ...
N. C. Miller, E. Cho, M. J. N. Junk, R. Gysel, C. Risko, D. Kim, S. Sweetnam, C. E. Miller, L. J. Richter, R. J. Kline, M. Heeney, I. McCulloch, A. Amassian, D. Acevedo-Feliz, C. Knox, M. R. Hansen, D. Dudenko, B. F. Chmelka, M. F. Toney, J.-L. Brédas, and M. D. ...
Product description and procedure summary: Target cells are positively selected or depleted by incubating the sample with an anti-human PE conjugated antibody, followed by incubation with magnetic anti-PE Nanobeads. The magnetically labeled fraction is retained by the use of a magnetic separator. These are the PE+ cells, do not discard them if those are the cells of interest. Some of the downstream applications include functional assays, gene expression, phenotypic characterization, etc.. Note: This procedure is optimized for the isolation of 107 to 2 x 108 cells per tube. If working with fewer than 107 cells, keep volumes as indicated for 107 cells. For best results, optimize the conditions to your specific cell number and tissue. Prepare fresh MojoSort™ Buffer solution by diluting the 5X concentrate with sterile distilled water. Scale up volumes if using 14mL tubes and Magnet, and place the tube in the magnet for 10 minutes.. ...
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Silverman on causes viral gastroenteritis: It is a viral infection of the GI tract. It can be picked up from contact with surfaces, foods, living things, etc. That are carrying the virus. The best prevention is frequent hand washing and proper food preparation. for topic: Causes Viral Gastroenteritis
Labeled structures: 1. Schwalbe's line, 2. Trabecular meshwork (TM), 3. Scleral spur, 4. Ciliary body, 5. Iris Anterior chamber ... of the ciliary muscle, and is attached anteriorly to the trabecular meshwork. Open-angle glaucoma (OAG) and closed-angle ... which cause rapid miosis and contraction of the ciliary muscles, this pulls the scleral spur and results in the trabecular ...
Anterior uveitis is an inflammatory process affecting the iris and ciliary body, with resulting inflammatory signs in the ... Labeled structures: 1. Schwalbe's line, 2. Trabecular meshwork (TM), 3. Scleral spur, 4. Ciliary body, 5. Iris Anterior chamber ...
"Iris and Ciliary body". Current Ocular Therapy (6 ed.). p. 518.CS1 maint: multiple names: authors list (link) Mitchel Scheiman ... Unilateral excessive accommodation-Trigeminal neuralgia, and head trauma may cause ciliary spasm and may cause accommodative ... Bilateral excessive accommodation-Diseases like Encephalitis, Syphilis, Head trauma, Influenza, Meningitis may cause ciliary ...
PMID 23271885.CS1 maint: multiple names: authors list (link) Ali MJ, Honavar SG, Vemuganti GK (2013). "Ciliary body ... "Leucocoria as the presenting sign of a ciliary body melanoma in a child". Br J Ophthalmol. 85 (1): 115-6. doi:10.1136/bjo.85.1. ... "Malignant teratoid ciliary body medulloepithelioma in a neonate". J Pediatr Ophthalmol Strabismus. 50 Online: e37-40. doi: ... "Ciliary body medulloepithelioma: analysis of 41 cases". Ophthalmology. 120 (12): 2552-2559. doi:10.1016/j.ophtha.2013.05.015. ...
... , or ciliary body medulloepithelioma, or teratoneuroma, is a rare tumor arising from primitive medullary epithelium in ... the ciliary body of the eye. Almost all diktyomas arise in the ciliary body, although, rarely, they may arise from the optic ... On CT, dityomas typically appear as dense, irregular masses in the ciliary body, which enhances with administration of ... while the most common signs are leukocoria and presence of a mass in the iris or ciliary body. Other signs and symptoms include ...
... is involved in the maintenance of ciliary basal bodies. Mutations in rotatin result in fewer, abnormally short cilia, ... with bulbous tips and multiple basal bodies. It is also involved in the radial migration of neurons in the cerebral cortex and ...
This technique was demonstrated in the iris and ciliary body and was eventually patented. Dr. Silverman described the first use ... This project involved direction of an intense focused ultrasound beam at the region of the ciliary body to cause ... High-resolution ultrasonic imaging and characterization of the ciliary body. Invest Ophthalmol Vis Sci. 42:885-894, 2001. ...
These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma. ... Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is ... "Ciliary Body Melanoma - The Eye Cancer Network". Archived from the original on 2009-08-20. Retrieved 2010-03-10. "The Nevus of ... Choroidal hemangioma Choroidal melanoma Choroidal metastasis Choroidal nevus Choroidal osteoma Ciliary body melanoma The nevus ...
Certain cells within the eye's ciliary body produce aqueous humor. A ciliary destructive or cyclodestructive procedure is one ... A cyclogoniotomy is a surgical procedure for producing a cyclodialysis, in which the ciliary body is cut from its attachment at ... Cyclophotocoagulation, also known as transscleral cyclophotocoagulation, ciliary body ablation, cyclophotoablation, and ... A surgical cyclodialysis is a rarely used procedure that aims to separate the ciliary body from the sclera to form a ...
The middle portion of the optic cup develops into the ciliary body and iris. During the invagination of the optic cup, the ... Neuroectoderm gives rise to the following compartments of the eye: retina epithelial lining of ciliary body and iris optic ... Neuroepithelium forms the retina, ciliary body, iris, and optic nerves. Surface ectoderm forms the lens, corneal epithelium and ...
Aqueous humor is produced in the portion of the eye known as the ciliary body. The ciliary body contains 72 protrusions known ... The stent is implanted through an ab interno approach and inserted into the supraciliary space (between the ciliary body and ... Chen J, Cohn RA, Lin SC, Cortes AE, Alvarado JA (December 1997). "Endoscopic photocoagulation of the ciliary body for treatment ... The destruction of these ciliary processes with a diode laser, known as cyclophotocoagulation, can be used to decrease the ...
2003). "BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen". Invest. Ophthalmol. Vis. Sci. 44 (1): ...
A cyclectomy is an excision of portion of the ciliary body. A cyclotomy, or cyclicotomy, is a surgical incision of the ciliary ... A ciliectomy is the surgical removal of part of the ciliary body or the surgical removal of part of a margin of an eyelid ... A corectomedialysis, or coretomedialysis, is an excision of a small portion of the iris at its junction with the ciliary body ... An iridocyclectomy is the surgical removal of the iris and the ciliary body. An iridocystectomy is the surgical removal of a ...
"Ciliary proteins link basal body polarization to planar cell polarity regulation". Nature Genetics. 40 (1): 69-77. doi:10.1038/ ...
Ciliary body (with a: pars plicata and b: pars plana) and 16. Choroid); 17. Ora serrata, 18. Vitreous humor with 19. Hyaloid ... 1. Lens, 2. Zonule of Zinn or Ciliary zonule, 3. Posterior chamber and 4. Anterior chamber with 5. Aqueous humour flow; 6. ... Blood vessels of the retina; Ciliary arteries (34. Short posterior ones, 35. Long posterior ones and 37. Anterior ones). 38. ...
This reduces cAMP and hence aqueous humour production by the ciliary body. Peripheral α2 agonist activity results in ... This may lead to relaxed ciliary muscle and increased uveoscleral outflow. It is sold under the brand names Alphagan, Alphagan- ...
It is secreted from the ciliary body, a structure supporting the lens. It fills both the anterior and the posterior chambers of ... Prevents eye dryness Aqueous humour is secreted into the posterior chamber by the ciliary body, specifically the non-pigmented ... Ciliary body, and Ora serrata Vitreous Humour Human Physiology. An Integrate approach. 5th edition. Dee Unglaub Silverthorn " ... epithelium of the ciliary body (pars plicata). 5 alpha-dihydrocortisol, an enzyme inhibited by 5-alpha reductase inhibitors, ...
Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA (2006). "FGF19 is a target for FOXC1 regulation in ciliary body- ...
Cloquet's space: A space between the ciliary zonule and the vitreous body. "Parts of this article are based on a translation of ...
... is attached to the sclera and the anterior ciliary body. The iris and ciliary body together are known as the anterior uvea. ... The ciliary zone is the rest of the iris that extends to its origin at the ciliary body. The collarette is the thickest region ... The iris along with the anterior ciliary body provide a secondary pathway for aqueous humour to drain from the eye. The iris is ... The structural folds of Schwalbe are radial folds extending from the border of the ciliary and pupillary zones that are much ...
Activity of renin and angiotensin converting enzyme in retina and ciliary body. (In Serbo-croatian). Liječ Vjes 1977;99:482-4. ...
His research has focused on melanoma of the choroid, ciliary body and iris. He has written extensively about new ways to detect ...
The ciliary organelles are present in many cellular types throughout the human body. Cilia defects adversely affect numerous ... OFD1 localizes to both centrosomes and basal bodies within the human genetic cellular structure. This suggests that this ... Other known ciliopathies include primary ciliary dyskinesia, Bardet-Biedl syndrome, polycystic kidney disease and polycystic ... Orofaciodigital syndrome type 1 can be treated with reconstructive surgery or the affected parts of the body. Surgery of cleft ...
Her work has also identified mechanistic underpinnings of developmental abnormalities including choroid plexus and ciliary body ... "Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors". The American Journal of Pathology. ...
... melanoma of the ciliary body, Norrie disease, ocular toxocariasis, persistence of the tunica vasculosa lentis (PFV/PHPV), ... "Leucocoria as the presenting sign of a ciliary body melanoma in a child". The British Journal of Ophthalmology. 85 (1): 115-6. ...
The latter type dominates in the ciliary body, where it controls aqueous humour production. Blocking this type of receptor ...
Anterior uveitis (inflammation of the iris and ciliary body) is most common in dogs. The disease is usually immune-mediated in ... Foreign body is an object foreign to the body that becomes lodged in the gastrointestinal tract (or other part of the dog). ... Foreign bodies most commonly become lodged in the stomach because of the inability to pass through the pyloric sphincter, and ... White dog shaker syndrome causes full body tremors in small, white dog breeds. It is most common in West Highland White ...
The ciliary muscles originate at the sclera and are located within the ciliary body. These muscles are striated and function to ... The feathers on its body generally do not grow over the eyes. The ridge protects the eyes from protruding tree branches when it ... Despite the name bald eagles are not hairless, their head is covered in white feathers contrasting with their dark brown body ... facilitates the fluids to flow through the vitreous body at an appropriate pressure, absorbs light to minimize any reflections ...
... ciliary body and iris while the nervous layer terminates just before the ciliary body. This point is the ora serrata. In this ... The ora serrata is the serrated junction between the retina and the ciliary body. This junction marks the transition from the ... non-photosensitive area of the ciliary body to the complex, multi-layered, photosensitive region of the retina. The pigmented ... Vessels of the choroid, ciliary processes, and iris of a child. Partial section of the human eye Human eye Anatomy photo:29:22- ...
The choriocapillaris is unique to the choroid and does not continue into the ciliary body. ImranBhutto,GerardLutty (1967-09-01 ...
Ciliary body. *Uveitis. *Intermediate uveitis. *Hyphema. *Rubeosis iridis. *Persistent pupillary membrane. *Iridodialysis ...
Farther back is the cell body, which contains the cell's organelles. Farther back still is the inner segment, a specialized ... Richardson, T.M. (1969). "Cytoplasmic and ciliary connections between the inner and outer segments of mammalian visual ... These cells are involved in various reflexive responses of the brain and body to the presence of (day)light, such as the ...
Iris, ciliary body,. sclera, and anterior chamber. *Glaucoma surgery: Trabeculectomy. *Iridectomy. Lens. *Phacoemulsification ...
ciliary rootlet. • neuron projection. • gamma-secretase complex. • cell nucleus. • kinetochore. • centrosome. • rough ... neuronal cell body. • perinuclear region of cytoplasm. • early endosome. • synaptic vesicle. • macromolecular complex. • ...
Ciliary body. *Uveitis. *Intermediate uveitis. *Hyphema. *Rubeosis iridis. *Persistent pupillary membrane. *Iridodialysis ...
Ciliary body. *Ciliary processes. *Ciliary muscle. *Pars plicata. *Pars plana. Iris. *Stroma ...
পক্ষ্মল অঙ্গক (Ciliary body). *অক্ষিকাচ (অক্ষি পরকলা) (lens). *অক্ষিপট (Retina). *দর্শন স্নায়ু (Optic nerve) ...
The pressure within the eye is maintained by the balance between the fluid that enters the eye through the ciliary body and the ...
Most do not affect other parts of the body, nor are they related to diseases affecting other parts of the eye or body. ... corneal foreign body sensation and severe progressive loss of vision. Lisch epithelial corneal dystrophy is characterized by ...
Known ciliopathies include primary ciliary dyskinesia, Bardet-Biedl syndrome, polycystic kidney and liver disease, ... organelles which are present in many cellular types throughout the human body. The cilia defects adversely affect "numerous ...
... occurring on average about 60,000 times a day per cell of the human body (see DNA damage (naturally occurring)). These damages ... genetically identical cells show heritable differences in the patterns of ciliary rows on their cell surface. Experimentally ...
These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma. ... "Ciliary Body Melanoma - The Eye Cancer Network". Retrieved 2010-03-10.. *^ "The Nevus of Ota - The Eye Cancer Network". ... Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is ... The second most common is medulloepithelioma (also called diktyoma) which can occur in the ciliary body and the uvea of the eye ...
... which involves abnormal copper handling by the liver resulting in copper accumulation in the body and is characterised by ...
The gritty or scratchy feeling is sometimes localized enough that patients may insist that they have a foreign body in the eye ... Viral conjunctivitis manifests as a fine, diffuse pinkness of the conjunctiva, which is easily mistaken for a ciliary infection ...
... and to the bodies of the vertebrae. It then anastomoses with the ascending pharyngeal and occipital arteries. ... ciliary (short posterior, long posterior, anterior). *Circulus arteriosus major. *hypophysial (superior, inferior) ...
The axon can synapse onto a dendrite, onto a cell body, or onto another axon or axon terminal, as well as into the bloodstream ... Stanley, EF (1992). "The calyx-type synapse of the chick ciliary ganglion as a model of fast cholinergic transmission". ... Santiago Ramón y Cajal proposed that neurons are not continuous throughout the body, yet still communicate with each other, an ... The distinctive structure of nerve cells allows action potentials to travel directionally (from dendrites to cell body down the ...
There are no ciliary muscles. The choroid is very thick and contains a fibrous tapetum lucidum. Like other toothed whales, the ... Sperm whales are prodigious feeders and eat around 3% of their body weight per day. The total annual consumption of prey by ... Goold, J.C. (1996). "Signal processing techniques for acoustic measurement of sperm whale body lengths". Journal of the ... The sperm whale's unique body is unlikely to be confused with any other species. The sperm whale's distinctive shape comes from ...
পক্ষ্মল অঙ্গক (Ciliary body). *অক্ষিকাচ (অক্ষি পরকলা) (lens). *অক্ষিপট (Retina). *দর্শন স্নায়ু (Optic nerve) ... Body of epididymis; L.) Mediastinum; M.) Vas deferens. ... কাচসদৃশ অঙ্গ (Vitreous body). *ঐক্ষিক বহিঃস্তর (গুরুমস্তিষ্ক) ( ...
Ganglion cell bodies (and some displaced amacrine cells) Hypo-reflective [23] 5. Inner plexiform layer (IPL). Synapses between ... The photoreceptor cell bodies 9. External limiting membrane (ELM) Made of zonulae adherens between Müller cells and ... The vertebrate retina has ten distinct layers.[13] From closest to farthest from the vitreous body: *Inner limiting membrane - ... The optic nerve is a central tract of many axons of ganglion cells connecting primarily to the lateral geniculate body, a ...
Ciliary body. *Uveitis. *Intermediate uveitis. *Hyphema. *Rubeosis iridis. *Persistent pupillary membrane. *Iridodialysis ...
Ciliary body. *Uveitis. *Intermediate uveitis. *Hyphema. *Rubeosis iridis. *Persistent pupillary membrane. *Iridodialysis ...
The most likely way for muscarine to leave the blood is via renal clearance; it will eventually leave the body in urine.[19] ... Muscarinic antagonists dilate the pupil and relax the ciliary muscle, are used in treatment of inflammatory uveitis and is ... A paucity of research exists on the metabolism of muscarine in the human body, suggesting this compound is not metabolized by ...
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body ... ciliary (short posterior, long posterior, anterior). *Circulus arteriosus major. *hypophysial (superior, inferior) ... In contrast, occlusion of the blood vessel by atherosclerotic plaque, by an embolised blood clot or a foreign body leads to ... In general, arteries and arterioles transport oxygenated blood from the lungs to the body and its organs, and veins and venules ...
ciliary basal body. • periciliary membrane compartment. • USH2 complex. • Cellbilen. • neuronal cell body. • cell junction. • ... Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau ...
ciliary (short posterior, long posterior, anterior). *Circulus arteriosus major. *hypophysial (superior, inferior) ...
Ciliary body. *Uveitis. *Intermediate uveitis. *Hyphema. *Rubeosis iridis. *Persistent pupillary membrane. *Iridodialysis ...
Loss of hair from other parts of the body, mainly the scalp ...
睫狀神經節副交感根(英语:parasympathetic root of ciliary ganglion)/睫狀神經節 ... 人體神經列表(英语:List of nerves of
It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... It has been suggested that pathologic generation of nitric oxide through increased iNOS production may decrease tubal ciliary ... eNOS is associated with "caveolae" a component of plasma membranes surrounding cells, and the membranes of Golgi bodies within ...
The receptive field is the area of the body or environment to which a receptor organ and receptor cells respond. For instance, ... The end-bulb of Krause, or bulboid corpuscle, detects temperatures above body temperature. ... as well as on the surface of the body. Nociceptors detect different kinds of damaging stimuli or actual damage. Those that only ... that detect stimuli as liquids include the taste buds in the gustatory system as well as receptors in the aortic bodies which ...
2008) Ciliary Body Melanoma. In: Clinical Ophthalmic Echography. Springer, New York, NY. * DOI https://doi.org/10.1007/978-0- ... Primary Cyst High Frequency Probe Nuclear Sclerosis Annual Exam Body Cyst These keywords were added by machine and not by the ...
The ciliary body produces the fluid in the eye called aqueous humor. It also contains the ciliary ... The ciliary body is a circular structure that is an extension of the iris, the colored part of the eye. ... The ciliary body is a circular structure that is an extension of the iris, the colored part of the eye. The ciliary body ... It also contains the ciliary muscle, which changes the shape of the lens when your eyes focus on a near object. This process is ...
The ciliary body contains smooth muscle fibers called ciliary muscles that help to control the shape of the lens. Towards the ... The ciliary body is a ring of tissue that encircles the lens. ... The ciliary body contains smooth muscle fibers called ciliary ... The ciliary body is a ring of tissue that encircles the lens. ... Towards the posterior surface of the lens there are ciliary ...
JNeurosci Print ISSN: 0270-6474 Online ISSN: 1529-2401. The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturers claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.. ...
Ciliary body melanoma (see the image below) is a rare tumor. It is encountered approximately one tenth as often as is choroidal ... encoded search term (Ciliary Body Melanoma) and Ciliary Body Melanoma What to Read Next on Medscape. Related Conditions and ... Some ciliary body melanomas with diffuse growth patterns can extend around the circumference of the ciliary body for 360°. ... The uvea is subdivided into the iris, ciliary body, and choroid. The ciliary body is located between the iris and the ora ...
The ciliary body joins the ora serrata of the choroid to the root of the iris. The ciliary body is a ring-shaped thickening of ... The ciliary body is a part of the eye that includes the ciliary muscle, which controls the shape of the lens, and the ciliary ... The aqueous humor is produced in the non-pigmented portion of the ciliary body. The ciliary body is part of the uvea, the layer ... The ciliary body is also known to receive sympathetic innervation via long ciliary nerves. When test subjects are startled, ...
... with Choroidal and Ciliary Body Melanoma Long-term risk of local failure after proton therapy for choroidal/ciliary body ... Ciliary Body Melanoma is a type of cancer arising from the coloured part (uvea) of the eye. About 12% of uveal melanoma arise ... Enucleation (surgical removal of the eye) is the treatment of choice for large ciliary body melanomas. Small or medium sized ... Ocular oncology Uveal melanoma - melanoma of the eye Ciliary Body Melanoma - Springer Redirecting Microvascular Density in ...
I have learned that my dog has an "epithelial tumor of the ciliary body" in the eye itself, a"ciliary adenocarcinoma". I am ... The ciliary body is a structure that sits within the eye just behind the iris. It is responsible for producing the fluids that ... Primary tumors of the ciliary body are uncommon in dogs, and even less common in cats. They tend to occur in middle-age to ... However, metastasis of ciliary body adenocarcinomas seems to be uncommon, and tends to happen as the tumor gradually becomes ...
Ciliary proteins link basal body polarization to planar cell polarity regulation.. Jones C1, Roper VC, Foucher I, Qian D, ... We also show that the proper positioning of ciliary basal bodies and the formation of polarized cellular structures are ... Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during ... Here, we show that a gene encoding a ciliary protein (a ciliary gene), Ift88, also known as Polaris, is required for ...
The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.[1] It is ... The ciliary body has three functions: accommodation, aqueous humor production and the production and maintenance of the lens ... One of the most essential roles of the ciliary body is the production of the aqueous humor, which is responsible for providing ... It is the main target of drugs against glaucoma, as the ciliary body is responsible for aqueous humor production; lowering ...
Arkaitz Mucientes, Ana Márquez, Miguel Cordero-Coma, José Manuel Martín-Villa, Marina Begoña Gorroño-Echebarría, Ricardo Blanco, David Díaz Valle, José Manuel Benítez-del-Castillo, María José del Rio, Ana Blanco, Jose Luis Olea, Yolanda Cordero, María José Capella, Jacobo Gonzalez, Manuel Díaz-Llopis, Norberto Ortego-Centeno, Alfredo Adán, Ioana Ruiz-Arruza, Víctor Llorenç, Alejandro Fonollosa, Javier Martín ...
In this presentation from AAO 2016, James J. Augsburger, MD, argues that the most relevant information that is pertinent to diagnosis is gathered by looking at
ICD-9 code 364 for Disorders of iris and ciliary body is a medical classification as listed by WHO under the range - DISORDERS ... Disorders of iris and ciliary body (364). ICD-9 code 364 for Disorders of iris and ciliary body is a medical classification as ...
What is ciliary body inflammation? Meaning of ciliary body inflammation medical term. What does ciliary body inflammation mean? ... Looking for online definition of ciliary body inflammation in the Medical Dictionary? ciliary body inflammation explanation ... 3. Relating to certain structures of the eyeball (for example, ciliary body, ciliary muscle, ciliary process, anterior ciliary ... ciliary. (redirected from ciliary body inflammation). Also found in: Dictionary, Thesaurus. ciliary. [sil´e-ar″e] pertaining to ...
... ciliary+body+of+the+eye? Find a list of current medications, their possible side effects, dosage, and efficacy when used to ... treat or reduce the symptoms of inflammation+of+the+iris+and+ciliary+body+of+the+eye ... Considering taking medication to treat inflammation+of+the+iris+and+ciliary+body+of+the+eye? Below is a list of common ... 94 medications found for inflammation+of+the+iris+and+ciliary+body+of+the+eye ...
What is ciliary body? Meaning of ciliary body as a finance term. What does ciliary body mean in finance? ... Definition of ciliary body in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Ciliary body financial definition of ciliary body https://financial-dictionary.thefreedictionary.com/ciliary+body ... Body. (redirected from ciliary body). Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia, Wikipedia. Body. The ...
... but only mild vasoconstriction of the arterioles supplying the ciliary processes. ... The effects of intravitreally injected endothelin-1 on the iris-ciliary body microvasculature in rabbits Curr Eye Res. 1996 Jun ... On the theory that these effects might have resulted from a sustained reduction of blood flow to the ciliary body due to ET-1- ... in the present study we attempted to determine if ET-1 causes any changes in the vascular caliber of the iris-ciliary body. ...
Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally ... Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males Eur J Hum Genet. 2002 Nov;10(11 ... Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally ... with consequent increase in body mass. In 575 Caucasian men aged 59-73 years, the A/A genotype (frequency 1.9%) was associated ...
Positive regulation by ciliary basal body regulators of Hh [cytosol] * Positive regulation by ciliary basal body regulators ... ciliary basal body regulators of Hh [cytosol] (Taeniopygia guttata) ciliary basal body regulators of Hh [cytosol] (Xenopus ... ciliary basal body regulators of Hh [cytosol] (Sus scrofa) ... ciliary basal body regulators of Hh Stable Identifier R-HSA- ... ciliary basal body regulators of Hh [cytosol] (Rattus norvegicus) ...
Basal layer of ciliary body --, basal lamina of ciliary body The inner layer of the ciliary body, continuous with the basal ... Basal layer of ciliary body. From Biology-Online Dictionary , Biology-Online Dictionary ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Basal_layer_of_ciliary_body&oldid=57105" ... layer of the choroid and supporting the pigment epithelium of the ciliary retina. ...
... in the ciliary body, and 8% in the iris. Malignant melanoma ... Ciliary Body Melanoma Masquerading as Chronic Uveitis. The ... in the ciliary body, and 8% in the iris. Malignant melanoma involving ciliary body (CB) yields poor prognosis compared to other ... Ciliary body melanoma can present as refractory glaucoma and chronic uveitis. Direct treatment of the melanoma may be required ... During the surgery, we detected a brownish lesion in the ciliary body, at the 12 oclock position, suggestive of a melanoma. ...
We explain what iris and ciliary body tumours are. Causes and symptoms of these pathologies. ✅ Specialised treatment at ... The ciliary body is the area immediately behind the iris. It has two very important functions. The first is to produce aqueous ... They are tumours that occur inside the eye, specifically in the layer called the uvea which includes the iris, ciliary body and ... medulloepithelioma of the ciliary body or inflammatory pseudomotor. In any case, in order to make it easier to understand, we ...
Muscarinic cholinergic inhibition of adenylate cyclase in the rabbit iris-ciliary body and ciliary epithelium. ... Cholinergic inhibition of adrenergic neurosecretion in the rabbit iris-ciliary body. You will receive an email whenever this ... J E Jumblatt, G T North; Cholinergic inhibition of adrenergic neurosecretion in the rabbit iris-ciliary body.. Invest. ... Nuclear translocation of the cytoplasmic glucocorticoid receptor in the iris-ciliary body and adjacent corneoscleral tissue of ...
We present two cases of iris-ciliary body melanoma with different size. The performed surgery was a partial lamellar ... Sclerouvectomy plus intraoperative ophthalmic brachytherapy for iris-ciliary body melanomas.. Dec 21, 2020 ... in order to remove melanomas that involved the ciliary body and/or the choroid, while leaving intact the outer portion of the ...
Surface cholinesterase activity was found to be highest in ciliary body, lower in retina, and least in cornea and crystalline ... Butyrylcholinesterase was found to contribute some 50 per cent of surface enzyme activity in the ciliary body, retina, and lens ... Analysis of Cholinesterases of Intact Cat Cornea, Ciliary Body, Lens, and Retina ... Analysis of Cholinesterases of Intact Cat Cornea, Ciliary Body, Lens, and Retina ...
Ciliary neurotrophic factor (CNTF) potently reduces appetite and body weight in rodents and humans. We studied the short- and ... Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet- ... Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet- ... Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet- ...
Free, official info about 2015 ICD-9-CM diagnosis code 364.4. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
The ciliary body (CB) is a two-layered structure in the anterior eye, which is composed of the pigmented outer ciliary ... RBPJ-dependent and -independent Notch2 Signaling Regulates Ciliary Body Development in the Mouse Eye. dc.contributor.advisor. ... RBPJ-dependent and -independent Notch2 Signaling Regulates Ciliary Body Development in the Mouse Eye. ... Surprisingly, RBPJ-independent Notch2 modulates BMP signaling in the ciliary stroma cells via repressing the expression of two ...
... imaging uncovered a rhythmically active neuronal circuit for the coordination of ciliary activity across the whole body of a ... body-wide ciliary arrests. These three cells innervate all multiciliated cells in the body (with the exception of the metatroch ... 335 of these target the ciliated cells of the prototroch ciliary band. The MC neuron is the only neuron in the body that is ... These cells have their cell bodies below the ciliary photoreceptor cells in a region of VAChT expression, but we could not ...
A fine needle aspiration biopsy was performed that demonstrated a probable adenoma of the non-pigmented ciliary epithelium. ...
  • Ciliary body melanoma (see the image below) is a rare tumor. (medscape.com)
  • Transpupillary photograph of ciliary body melanoma. (medscape.com)
  • Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)
  • Uveal melanomas are the most common primary intraocular malignancies and the second most common type of primary malignant melanoma in the body. (medscape.com)
  • Fundus photograph of a large ciliary body melanoma. (medscape.com)
  • Melanoma in the ciliary body poses a serious threat to life. (medscape.com)
  • Patients who die from ciliary body melanoma die because of distant metastasis rather than local spread. (medscape.com)
  • Less frequently, ciliary body melanoma can grow transsclerally, through emissary channels, and can spread locally into the orbit and conjunctiva. (medscape.com)
  • Local growth of ciliary body melanoma produces signs and symptoms as it pathologically involves adjacent structures. (medscape.com)
  • Primary ciliary body melanoma arises from melanocytes in the uveal tract. (medscape.com)
  • Ciliary Body Melanoma is a type of cancer arising from the coloured part (uvea) of the eye. (wikipedia.org)
  • About 12% of uveal melanoma arise from the ciliary body. (wikipedia.org)
  • Ocular oncology Uveal melanoma - melanoma of the eye Ciliary Body Melanoma - Springer Redirecting Microvascular Density in Predicting Survival of Patients with Choroidal and Ciliary Body Melanoma Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma Redirecting Matched group study of surgical resection versus cobalt-60 plaque radiotherapy for primary. (wikipedia.org)
  • Taking into consideration all clinical features, despite patients' young age, malignant melanoma of the ciliary body was suspected. (unboundmedicine.com)
  • or acquired causes such as trauma, surgical defect, iris cyst, ciliary body melanoma, or synechiae, which is common in cases of trauma. (thefreedictionary.com)
  • Malignant melanoma involving ciliary body (CB) yields poor prognosis compared to other uveal melanomas. (uveitis.org)
  • During the surgery, we detected a brownish lesion in the ciliary body, at the 12 o'clock position, suggestive of a melanoma. (uveitis.org)
  • Evaluation by the retinal oncologists confirmed the suspicion that the mass was probably a ciliary body melanoma. (uveitis.org)
  • DISCUSSION: We have presented a case of probable ciliary body melanoma masquerading as chronic uveitis. (uveitis.org)
  • There is only one published report in the recent literature of a case of ciliary body melanoma masquerading as anterior uveitis and invading the optic nerve, leading to enucleation. (uveitis.org)
  • Ciliary body melanoma can present as refractory glaucoma and chronic uveitis. (uveitis.org)
  • We present two cases of iris-ciliary body melanoma with different size. (physiciansweekly.com)
  • A 47-year-old woman is suspected of having a ciliary body melanoma (A). Histologic sections (B and C) show large ciliary body tumor composed of tumor cells in a fibrillar cytoplasmic matrix. (blogspot.com)
  • Conditions: Name Ciliary Body Melanoma Description Ciliary body melanoma is more likely to present with extrascleral extension (seen as dark spots on the sclera). (drugster.info)
  • The differential diagnosis of ciliary body melanoma should be considered in cases of unilateral pigmentary glaucoma and chronic uveitis. (drugster.info)
  • Melanoma of the uveal tract (iris, ciliary body ,and choroid),though rare,is the most common primary intraocular malignancy in adults. (drugster.info)
  • Iris- Ciliary Body Melanoma . (drugster.info)
  • With interest we read the recent article by Khan et al investigating the ciliary body for the presence of peritumoral lymphatic vessels in uveal melanoma with and without extraocular extension. (linkoph.com)
  • Diffuse malignant ring melanoma of the iris and ciliary body. (mysciencework.com)
  • CILIARY BODY RING MELANOMA WITH EXTRAOCULAR EXTENSION - LEFT EYE DISCUSSION: I explained to the patient that unfortunately he does have a large melanoma in the left eye. (retinagallery.com)
  • This article provides a clinicopathologic correlation in two cases of ciliary body melanoma with almost total balloon cell transformation. (jamanetwork.com)
  • Although the preferred treatment for ANPCEs is local resection sparing the globe, they are often clinically indistinguishable from the more common ciliary body malignant melanoma that arises in the same location and thus are sometimes treated with unnecessary enucleation. (ajnr.org)
  • People with choroidal or ciliary body melanoma often don't have symptoms. (webmd.com)
  • The ciliary body joins the ora serrata of the choroid to the root of the iris. (wikipedia.org)
  • They can be classified as anterior uveal melanomas when the tumor arises in the iris and as posterior uveal melanomas when it arises in either the choroid or the ciliary body. (medscape.com)
  • The uvea is subdivided into the iris, ciliary body, and choroid. (medscape.com)
  • ciliary body the thickened part of the vascular tunic of the eye, connecting choroid and iris, made up of the ciliary muscle and the ciliary processes. (thefreedictionary.com)
  • Despite the highly invasiveness index of this tumor to the iris and ciliary body , they rarely affect the choroid. (thefreedictionary.com)
  • The inner layer of the ciliary body , continuous with the basal layer of the choroid and supporting the pigment epithelium of the ciliary retina . (biology-online.org)
  • 80% in the choroid, 12% in the ciliary body, and 8% in the iris. (uveitis.org)
  • They are tumours that occur inside the eye , specifically in the layer called the uvea which includes the iris, ciliary body and choroid. (barraquer.com)
  • Partial lamellar sclerouvectomy was designed more than 30 years ago by Jerry and Carol Shields, in order to remove melanomas that involved the ciliary body and/or the choroid, while leaving intact the outer portion of the sclera and the overlying sensory retina [1]. (physiciansweekly.com)
  • The ciliary body connects the choroid with the iris , and consists of three zones. (ivyroses.com)
  • Ciliary body leiomyoma is a benign smooth muscle neoplasm, usually found in the ciliary body and anterior choroid (iris lesions reported). (eyerounds.org)
  • The ciliary body is a muscular ring of tissue at the junction of the iris and the choroid. (cancer.ca)
  • Which four-letter word, beginning with "U", is the pigmented layer of the eye, lying beneath the sclera and cornea, and comprising the iris, choroid and ciliary body? (thefreedictionary.com)
  • Below you will be able to find the answer to The part of an eyeball consisting of the iris, ciliary body and choroid crossword clue which was last seen on Mirror - Quiz Crossword, August 8 2017 . (crossword365.com)
  • Since you landed on this page then you would like to know the answer to The part of an eyeball consisting of the iris, ciliary body and choroid . (crossword365.com)
  • Uveal melanomas are likely to be pigmented and lobulated primary choroid or ciliary body tumours but can also arise in the iris. (edu.au)
  • It's most likely to grow in the choroid, followed by the ciliary body and then the iris. (webmd.com)
  • The vascular layer is a pigmented region that include the iris, ciliary body, and choroid. (prezi.com)
  • It lies posterior to the cornea and is held in place by ligaments that orginate on the cillary body of the choroid. (prezi.com)
  • On the theory that these effects might have resulted from a sustained reduction of blood flow to the ciliary body due to ET-1-mediated vasoconstriction, in the present study we attempted to determine if ET-1 causes any changes in the vascular caliber of the iris-ciliary body. (nih.gov)
  • One h following these injections in five of the rabbits and 24 h following them in the other five rabbits, ocular microvascular castings were obtained under controlled physiologic conditions, and the amount of vasoconstriction of the arterioles branching from the major arterial circle of the iris (MAC) and supplying the iris-ciliary body was measured by a scanning electron microscope and expressed as a percentage. (nih.gov)
  • Cholinergic inhibition of adrenergic neurosecretion in the rabbit iris-ciliary body. (arvojournals.org)
  • The prejunctional effects of cholinergic agents on release of norepinephrine from sympathetic nerve endings were investigated in the isolated, superfused rabbit iris-ciliary body. (arvojournals.org)
  • Sclerouvectomy plus intraoperative ophthalmic brachytherapy for iris-ciliary body melanomas. (physiciansweekly.com)
  • In this study, Minilys has been compared to current method (Precellys) to homogenize whole iris-ciliary body from pork. (bertin-instruments.com)
  • H21.32 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of implantation cysts of iris, ciliary body or anterior chamber. (icdlist.com)
  • To investigate the characteristics of the size and distribution of primary iris-ciliary body cysts and its associated with the change of anterior chamber angle. (geoscience.net)
  • Any primary iris-ciliary body cysts detected were recorded in the parameters of quantity, size, location, and quadrant. (geoscience.net)
  • The 502 cysts were detected in 134 (29.32%) of the 457 patients, which were all primary iris-ciliary body cysts. (geoscience.net)
  • Primary tumors of the ciliary body are uncommon in dogs, and even less common in cats. (oncolink.org)
  • Can Imaging Discriminate Between Benign and Malignant Ciliary Body Tumors? (aao.org)
  • Tumors are abnormal growths in your body. (icdlist.com)
  • Although clinical recognition may be difficult, the use of needle biopsy coupled with cytologic diagnosis in selected ciliary body tumors may disclose balloon cell change and help to direct therapy. (jamanetwork.com)
  • 1 - 4 , 6 Because these tumors are located behind the iris in the ciliary body, they are difficult to see on slit-lamp examination. (ajnr.org)
  • Because the ciliary body produces aqueous humor, it is the main target of many medications against glaucoma. (wikipedia.org)
  • There 3 main types of medication affecting the ciliary body: Beta blockers, the second most common treatment method for glaucoma, reduce the production of aqueous humor. (wikipedia.org)
  • Furthermore, less selective alpha agonists such as [epinephrine] may decrease the production of aqueous humor through vasoconstriction of the ciliary body (only for open-angle glaucoma). (wikipedia.org)
  • Destruction of the ciliary body using various methods is an option for the management of refractory glaucoma when conventional medical and or surgical modalities fail to adequately control intraocular pressure (IOP). (thefreedictionary.com)
  • A 61-year-old woman suffered from recurrent self -limiting attacks of acute glaucoma due to angle-closure caused by the primary epithelial cysts of ciliary body that were present through its entire circumference. (bvsalud.org)
  • Relaxation of the ciliary muscle puts tension on these fibers and changes the shape of the lens in order to focus light on the retina. (wikipedia.org)
  • The inner layer is transparent and covers the vitreous body, and is continuous from the neural tissue of the retina. (wikipedia.org)
  • Surface cholinesterase activity was found to be highest in ciliary body, lower in retina, and least in cornea and crystalline lens. (arvojournals.org)
  • Butyrylcholinesterase was found to contribute some 50 per cent of surface enzyme activity in the ciliary body, retina, and lens, and 80 per cent in the cornea. (arvojournals.org)
  • Light rays pass through the lens and are focused on the retina to create images of objects at different distances from the body. (cancer.ca)
  • Presence of tyrosinase activity in human ciliary body. (semanticscholar.org)
  • Immunoblot showing the expression of OAT1, OAT3, and MRP4 in the human ciliary body of four different donors (1-4). (aspetjournals.org)
  • METHODS: Oatps/OATPs were detected by immunoblot analysis and by immunofluorescence microscopy in homogenized and fixed rat and human ciliary body samples using specific polyclonal antibodies. (unibas.ch)
  • Confocal immunofluorescence microscopy localized Oatp1a4 and Oatp1b2 as well as all immunoblot positive human OATPs at the basolateral plasma membrane of the non-pigmented rat and human ciliary body epithelium, respectively. (unibas.ch)
  • However, for human OATPs additional regional differences in expression were found with OATP1A2 and OATP1C1 being expressed only in the pars plana of human ciliary body epithelium. (unibas.ch)
  • CONCLUSIONS: Several multispecific organic anion transporting polypeptides are expressed at the basolateral plasma membrane of the non-pigmented, and to a lesser extent also of the pigmented, epithelium in rat and human ciliary body. (unibas.ch)
  • Towards the posterior surface of the lens there are ciliary processes which contain capillaries. (medlineplus.gov)
  • The ciliary body is a ring-shaped thickening of tissue inside the eye that divides the posterior chamber from the vitreous body. (wikipedia.org)
  • Folds on the inner ciliary epithelium are called ciliary processes, and these secrete aqueous humor into the posterior chamber. (wikipedia.org)
  • Post-operatively, ultrasonography confirmed a lesion of moderate echo adherent to posterior iris, within the ciliary sulcus. (uveitis.org)
  • Skeleton (Skeletal System) Anatomy and Nerves within Body Outline, Posterior View. (nucleusmedicalmedia.com)
  • Indeed, smaller pigmented episcleral lesions located within a 3- to 4-mm distance from the limbus, sometimes with an associated ciliary artery branch, might represent Axenfeld loops constituting an intrascleral loop of a long posterior ciliary nerve. (jamanetwork.com)
  • 1 Because they arise from the epithelial covering of the posterior aspect of the ciliary body, ANPCEs more commonly protrude posteriorly through the posterior chamber and into the vitreous chamber of the globe but may alternatively extend anteriorly through the peripheral iris into the anterior chamber. (ajnr.org)
  • Vitreous body (posterior): it is a gelatinous mass that helps to stabolize the shape of the eye, which might otherwise distort as the extrinsic muscles change its position within the orbit. (prezi.com)
  • The ciliary body produces the fluid in the eye called aqueous humor. (medlineplus.gov)
  • The ciliary body is a part of the eye that includes the ciliary muscle, which controls the shape of the lens, and the ciliary epithelium, which produces the aqueous humor. (wikipedia.org)
  • The aqueous humor is produced in the non-pigmented portion of the ciliary body. (wikipedia.org)
  • The ciliary body has three functions: accommodation, aqueous humor production and resorption, and maintenance of the lens zonules for the purpose of anchoring the lens in place. (wikipedia.org)
  • The ciliary epithelium of the ciliary processes produces aqueous humor, which is responsible for providing oxygen, nutrients, and metabolic waste removal to the lens and the cornea, which do not have their own blood supply. (wikipedia.org)
  • Separation and disruption of the overlying ciliary epithelium decreases its production of aqueous humor with consequent ocular hypotension. (medscape.com)
  • The ciliary body has three functions: accommodation, aqueous humor production and the production and maintenance of the lens zonules. (wikidoc.org)
  • One of the most essential roles of the ciliary body is the production of the aqueous humor, which is responsible for providing most of the nutrients for the lens and the cornea and involved in waste management of these areas. (wikidoc.org)
  • This can be explained by the lack of patients with OIS in our patient group and the absence of ciliary body ischemia caused by stenosis, in which case there is no reduction in aqueous humor production. (thefreedictionary.com)
  • blood-to-aqueous humor (blood-to-AH)] and net active flux of PAH across bovine ciliary body in Ussing chambers (A and B). (A) Representative time-course experiment ( n = 1). (aspetjournals.org)
  • Ocular examinations revealed severe iridocyclitis and high intraocular pressure and UBM revealed iris thickening and ciliary body swelling and many atypical lymphocytes were detected in the aqueous humor, leading us to suspect that lymphoma cells had invaded the eye. (elsevier.com)
  • Conclusion: Hematopoietic cancer cells can invade the aqueous humor and cause distinctive unilateral uveitis with iris thickening and ciliary body swelling. (elsevier.com)
  • The ciliary epithelium of the eye secretes the aqueous humor. (biomedsearch.com)
  • No pathology was found by light microscopy in all groups.Conclusions: This study demonstrates that subconjunctival antimetabolites mitomycin C and 5-fluorouracil can penetrate the sclera and exert toxiceffects on the epithelium of the ciliary body, even in low doses. (bgu.ac.il)
  • Adult ciliary body epithelial cells are a patient specific, multipotent cell source that can differentiate into cells that mimic RPE cells. (grantome.com)
  • The non-pigmented ciliary epithelial cells of the ciliary body pars plicata produce aqueous humour. (thefreedictionary.com)
  • Effect of coupling on volume-regulatory response of ciliary epithelial cells suggests mechanism for secretion. (biomedsearch.com)
  • Here, we identify ciliary body epithelial cells (CECs) as a new cell type for iPS cell generation that has higher reprogramming efficiency compared with fibroblasts. (unthsc.edu)
  • The ciliary body is composed of epithelial cells that are located in the anterior portion of the eye at the level of the lens and is readily surgically accessible. (unthsc.edu)
  • Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. (nih.gov)
  • Ciliary neurotrophic factor (CNTF) potently reduces appetite and body weight in rodents and humans. (diabetesjournals.org)
  • Administration of ciliary neurotrophic factor (CNTF), a neuronal growth factor studied in amyotrophic lateral sclerosis, results in anorexia and weight loss in humans ( 1 , 2 ) and mice ( 3 , 4 ). (diabetesjournals.org)
  • Ciliary Neurotrophic Factor (CNTF) is a neurotrophic factor with promising benefits in a wide range of pathologies such as neurodegenerative diseases, spinal cord injuries, retinal degeneration, autoimmune neuroinflammation and obesity-related metabolic diseases. (brainfogrelief.com)
  • The left eye has a hazy view of the fundus because of the brown lesion in the ciliary body, which is obscuring much of the fundus. (retinagallery.com)
  • The ciliary body also has cells that make aqueous humour, the jelly-like fluid in the front of the eye between the cornea and lens. (cancer.ca)
  • The proposed pathophysiological mechanism involves anticholinergic effects and a possible serotonergic mechanism due to the presence of 5-HT receptors in human eyes and their concentration in the mammalian ciliary body and cornea. (thefreedictionary.com)
  • Ciliary body melanomas can push the iris diaphragm anteriorly, or they can infiltrate the trabecular meshwork, producing acute angle closure. (medscape.com)
  • Beta]-adrenergic receptors are found on the ciliary body microvasculature and trabecular meshwork cells [8]. (thefreedictionary.com)
  • Nguyen of the University of California, San Francisco isolated a gene that is active in the trabecular meshwork and the ciliary body , the ocular structure that makes the clear fluid. (thefreedictionary.com)
  • It also contains the ciliary muscle, which changes the shape of the lens when your eyes focus on a near object. (medlineplus.gov)
  • It contains the ciliary muscle, vessels, and fibrous connective tissue. (wikipedia.org)
  • The ciliary body is a ring of tissue that encircles the lens. (medlineplus.gov)
  • The ciliary body contains smooth muscle fibers called ciliary muscles that help to control the shape of the lens. (medlineplus.gov)
  • The ciliary body is attached to the lens by connective tissue called the zonular fibers (fibers of Zinn). (wikipedia.org)
  • Accommodation essentially means that when the ciliary muscle contracts, the lens becomes more convex, generally improving the focus for closer objects. (wikipedia.org)
  • These provide strong attachments between the ciliary muscle and the capsule of the lens. (wikipedia.org)
  • When the ciliary muscle relaxes, it flattens the lens, generally improving the focus for farther objects. (wikidoc.org)
  • These processes radiate from the ciliary muscle and give attachment to ligaments supporting the lens of the eye. (thefreedictionary.com)
  • Much as the lens of a camera can adapt to focus on near or far objects, the ciliary body of the eye allows us to do the same. (thefreedictionary.com)
  • Type VII Collagen in the Human Accommodation System: Expression in Ciliary Body, Zonules, and Lens Capsule. (semanticscholar.org)
  • The ciliary muscle - which controls the curvature of the lens , and therefore its accommodation to enable us to view both close and distant objects according to where our vision is focused. (ivyroses.com)
  • Muscle fibres in the ciliary body help the eye to focus on near or far objects by changing the shape of the lens. (cancer.ca)
  • When cancer is in the ciliary body, it can push the lens of the eye out of place and blur your vision . (webmd.com)
  • Latanoprost may cause iris pigment epithelial and ciliary body cysts that remain clinically undetected. (uhblibrary.co.uk)
  • The aim of this report is to present a case of mesectodermal leiomyoma of the ciliary body. (unboundmedicine.com)
  • Mesectodermal leiomyoma of the ciliary body is an extremely rare benign tumor, which originates from neural crests. (unboundmedicine.com)
  • AU - Sojka,Paulina, AU - Pogrzebielski,Arkadiusz, AU - Orłowska-Heitzman,Jolanta, AU - Romanowska-Dixon,Bozena, PY - 2010/2/23/entrez PY - 2010/2/23/pubmed PY - 2010/4/3/medline SP - 350 EP - 3 JF - Klinika oczna JO - Klin Oczna VL - 111 IS - 10-12 N2 - PURPOSE: The aim of this report is to present a case of mesectodermal leiomyoma of the ciliary body. (unboundmedicine.com)
  • CONCLUSIONS: Mesectodermal leiomyoma of the ciliary body is an extremely rare benign tumor, which originates from neural crests. (unboundmedicine.com)
  • Clinicopathologic Correlation: Ciliary Body Leiomyoma. (eyerounds.org)
  • Ocular examination findings of anterior uveitis in his left eye with iris thickening and ciliary body swelling were confirmed by ultrasound biomicroscopy (UBM). (elsevier.com)
  • These findings may contribute to the theory that the application ofantimetabolites during or after surgery has a direct effect on the epithelium of the ciliary body, besides its known effect on the conjunctiva. (bgu.ac.il)
  • Enucleation (surgical removal of the eye) is the treatment of choice for large ciliary body melanomas. (wikipedia.org)
  • The ciliary body (CB) is a two-layered structure in the anterior eye, which is composed of the pigmented outer ciliary epithelium (OCE) and the non-pigmented inner ciliary epithelium (ICE). (ku.edu)
  • The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes . (wikidoc.org)
  • Intravitreally injected ET-1 caused statistically significant, but only mild vasoconstriction of the arterioles supplying the ciliary processes. (nih.gov)
  • This report describes a case of ciliary body adenoma of NPCE in a 27 year old Pakistani man. (elsevier.com)
  • abstract = "Background: Iris thickening and ciliary body swelling associated with hematopoietic malignancy are uncommon. (elsevier.com)
  • abstract = "The motive forces for ciliary movement are generated by large multiprotein complexes referred to as outer dynein arms (ODAs), which are preassembled in the cytoplasm prior to transport to the ciliary axonemal compartment. (edu.au)
  • However, metastasis of ciliary body adenocarcinomas seems to be uncommon, and tends to happen as the tumor gradually becomes larger and more invasive. (oncolink.org)
  • Unusual solitary metastasis of the ciliary body in renal cell carcinoma. (thefreedictionary.com)
  • We may also enconter lesions that come from other tissues where the primary tumour originated such as metastasis, lymphoma, medulloepithelioma of the ciliary body or inflammatory pseudomotor. (barraquer.com)
  • The ciliary body is part of the uvea, the layer of tissue that delivers oxygen and nutrients to the eye tissues. (wikipedia.org)
  • A focused beam of ultrasound is targeted on the ciliary body , the portion of the eye that creates fluid within the eyeball. (thefreedictionary.com)
  • In July, 1997, retinal examination and ultrasound biomicroscopy showed that the ciliary body mass had enlarged, to approximately 7.0 x 6.0 x 4.2 mm, with extension into the limbus. (uveitis.org)
  • In contrast, ultrasound probes used for purposes such as obstetrics use lower frequencies for deeper penetration into the body, and, because the structures being imaged are larger, they do not require the same degree of resolution. (medscape.com)
  • A fine needle aspiration biopsy was performed that demonstrated a probable adenoma of the non-pigmented ciliary epithelium. (gonioscopy.org)
  • Mansoor, S & Qureshi, A 2004, ' Ciliary body adenoma of non-pigmented epithelium ', Journal of Clinical Pathology , vol. 57, no. 9, pp. 997-998. (elsevier.com)
  • D31.40 is a billable code used to specify a medical diagnosis of benign neoplasm of unspecified ciliary body. (icdlist.com)
  • There are only 27 documented cases of acquired neoplasm of the non-pigmented ciliary epithelium (NPCE) reported in the English literature. (elsevier.com)
  • The purpose of this study was to present a case of paraneoplastic systemic hypertension and fever in an undiagnosed primary ciliary body carcinoma arising in a painful blind eye. (biomedcentral.com)
  • ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. (nature.com)
  • Kartagener's syndrome is a type of ciliary motility disorder called primary ciliary dyskinesia. (thefreedictionary.com)
  • Yet there have been few reports of secondary iris pigment epithelial (IPE) and ciliary body (CB) cyst formation to date and none, to our knowledge, reported in eyes predisposed to primary angle closure. (uhblibrary.co.uk)
  • In humans, defects in structural components, docking complexes, or cytoplasmic assembly factors can cause primary ciliary dyskinesia (PCD), a disorder characterized by chronic airway disease and defects in laterality. (edu.au)
  • It is a double epithelium arranged so that the apical surfaces of the nonpigmented ciliary epithelial (NPCE) and pigmented ciliary epithelial (PCE) cells face each other and the basolateral membranes face the inside of the eye and the blood, respectively. (biomedsearch.com)
  • peripheral hyperemia of the anterior ciliary vessels which produces a deep red or rose color of the corneal stroma, and must be distinguished from hyperemia of the conjunctival vessels. (thefreedictionary.com)
  • A tiny gland, called the ciliary body , located behind the iris produces the fluid. (thefreedictionary.com)
  • fruiting body a specialized structure of certain fungi that produces the spores. (thefreedictionary.com)
  • Straightening of the body axis is a major morphogenetic event that produces the typical head-to-tail shape of the vertebrate embryo. (nature.com)
  • We also show that the proper positioning of ciliary basal bodies and the formation of polarized cellular structures are disrupted in mice with mutant ciliary proteins ('ciliary mutants'), whereas core PCP proteins are partitioned normally along the polarization axis. (nih.gov)
  • Fig. 1: Body curvature correlates with impaired cilia-driven CSF flow in ciliary mutants. (nature.com)
  • Podoplanin immunopositivity was shown to be present in all trabecular cells, the cells of the trabeculum ciliare, and the anterior-most perimysium cells of the ciliary muscle (, available at http://aaojournal.org). (linkoph.com)
  • Ciliary body melanomas are mostly found in whites, particularly in those with light-colored irides. (medscape.com)
  • Those are closely related to melanomas of the skin in other parts of your body. (webmd.com)
  • Multi-ciliary arrays promote fluid flow and cellular motility using the polarized and coordinated beating of hundreds of motile cilia. (rupress.org)
  • Here, we show that a gene encoding a ciliary protein (a 'ciliary gene'), Ift88, also known as Polaris, is required for establishing epithelial PCP and for convergent extension of the cochlear duct of Mus musculus. (nih.gov)
  • The effect of CNTF Ax15 on food intake and body weight was more pronounced in CNTF Ax15 -treated diet-induced obese C57BL/6J mice compared with pair-fed controls and was associated with suppressed expression of hypothalamic neuropeptide Y and agouti gene-related protein. (diabetesjournals.org)
  • TFs form a pinwheel-like structure, of unknown protein composition, that links the BB to the proximal ciliary membrane. (rupress.org)
  • Satir and Christensen, 2007 ) that excludes vesicles from cilia, prevents unwanted diffusion of membrane proteins into cilia, and selectively regulates protein ciliary entry and exit ( Fig. 1 A ). (rupress.org)
  • In this study, changes of ciliary body thickness and aqueous protein concentration before and after operation were studied to explore the impact on 23G and 20G vitrectomy. (springermedizin.de)
  • Latanoprost Induced Iris Pigment Epithelial and Ciliary Body Cyst Formation in Hypermetropic Eyes. (uhblibrary.co.uk)
  • Adenomas of the non-pigmented epithelium of the ciliary body are rare neoplasms and most of the studies are in the form of case reports. (elsevier.com)
  • For example, if there is no visual potential for the eye, and IOP is elevated causing pain, diode laser destruction of the ciliary body can be attempted to reduce production of aqueous fluid. (thefreedictionary.com)
  • Postsynaptic fibers from the ciliary ganglion form the short ciliary nerves. (wikipedia.org)
  • Tetrahymena basal bodies (BBs) nucleate and position cilia, whereby BB-associated striated fibers (SFs) promote BB anchorage and orientation into ciliary rows. (rupress.org)
  • the contraction of these fibers likely results in straightening of the body axis. (nature.com)
  • In conclusion, we have identified a novel conserved ciliary gene noni, which is necessary for ciliary function and planar cell polarity in zebrafish. (biomedcentral.com)
  • There are three sets of ciliary muscles in the eye, the longitudinal, radial, and circular muscles. (wikidoc.org)
  • The ciliary vessels are located medially and the inferior oblique muscles are located laterally to the optic nerve. (edu.au)
  • used particularly in reference to certain eye structures, as the ciliary body or muscle. (thefreedictionary.com)
  • other ciliary structures are located on type I and II hair cells of the maculae of the inner ear, on hair cells of the organ of Corti, and on ciliated columnar epithelium of respiratory tract. (thefreedictionary.com)
  • 3. Relating to certain structures of the eyeball (for example, ciliary body, ciliary muscle, ciliary process, anterior ciliary vein). (thefreedictionary.com)
  • 2. Of or relating to the ciliary body and associated structures of the eye. (thefreedictionary.com)
  • Evolutionarily convergent features in the development of these abbreviated forms include large eggs, bullet-shaped larval bodies, loss of feeding structures and a larval skeleton, the presence of uniform ciliation or transverse ciliary bands used for swimming, and decreased time to the juvenile stage (Emlet et al. (thefreedictionary.com)
  • Across the Tree of Life, such large ciliary structures are only found in comb jellies. (thefreedictionary.com)
  • These Oatps/OATPs can account for the previously suggested 'liver-like' transport functions of mammalian ciliary body epithelium. (unibas.ch)
  • Ciliary proteins link basal body polarization to planar cell polarity regulation. (nih.gov)
  • Basal bodies, kinocilia and planar cell polarity. (nih.gov)
  • Moreover, noni morphants have defects in body axis elongation and present impaired basal body positioning in the floor plate suggesting that noni is implicated in planar cell polarity (PCP). (biomedcentral.com)
  • Parasympathetic activation of the M3 muscarinic receptors causes ciliary muscle contraction, the effect of contraction is to decrease the diameter of the ring of ciliary muscle. (wikipedia.org)
  • The first one suggests that the tumor is derived from the smooth muscle layer of vessel walls, while the second one proposes the ciliary muscle itself as the tumor origin. (eyerounds.org)
  • It's elasticated and can adapt its shape using the ciliary muscle in order to focus on objects both close up and at long range. (zeiss.com)
  • ICD-9 code 364 for Disorders of iris and ciliary body is a medical classification as listed by WHO under the range -DISORDERS OF THE EYE AND ADNEXA (360-379). (aapc.com)
  • Genetic disorders causing anomalies of the dynein arms of cilia result in ciliary dyskinesia, for example, Kartagener syndrome. (thefreedictionary.com)
  • There are blood test, ciliary function test, CT scan of the sinuses, nasal cytology and allergy testing and MRI of the sinuses. (thefreedictionary.com)