AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth CareGeographicals
CilazaprilPyridazinesAngiotensin-Converting Enzyme InhibitorsHeart RateRamiprilEnalaprilHepatitis, Infectious CanineVascular ResistanceAngioedemaCoughAngioedemas, HereditaryHereditary Angioedema Types I and IIAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary VesselsCoronary DiseaseDouble-Blind MethodAntihypertensive AgentsNifedipineQuality of LifeHypertensionBlood PressureHypertrophy, Left VentricularInternetDeveloping CountriesSoftwareMedication ErrorsWaiting ListsMedication AdherenceDeveloped CountriesAlprazolamHydrochlorothiazideTetrahydroisoquinolinesExcipientsDrug Information ServicesPamphletsDrug LabelingPatient Education as TopicFormularies as TopicDrug IndustryMedical Records Systems, ComputerizedPregnancy TestsMisoprostolContraceptives, OralVasectomyProtective DevicesDiclofenacOvulation DetectionBumetanidePhysician-Patient RelationsUnited States Food and Drug AdministrationPhytotherapyDrugs, Chinese HerbalUnited StatesUniversal Precautions
Cilazapril
One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
Pyridazines
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Heart Rate
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Ramipril
A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
Enalapril
An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.
Hepatitis, Infectious Canine
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Vascular Resistance
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Angioedema
Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
Cough
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Angioedemas, Hereditary
Inherited disorders that are characterized by subcutaneous and submucosal EDEMA in the upper RESPIRATORY TRACT and GASTROINTESTINAL TRACT.
Hereditary Angioedema Types I and II
Forms of hereditary angioedema that occur due to mutations in the gene for COMPLEMENT C1 INHIBITOR PROTEIN. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein.
Angioplasty, Balloon, Coronary
Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.
Coronary Angiography
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Coronary Vessels
The veins and arteries of the HEART.
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Nifedipine
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Quality of Life
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Blood Pressure
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Hypertrophy, Left Ventricular
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Developing Countries
Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.
Software
Sequential operating programs and data which instruct the functioning of a digital computer.
Medication Errors
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
Waiting Lists
Prospective patient listings for appointments or treatments.
Medication Adherence
Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
Developed Countries
Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.
Alprazolam
A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)
Hydrochlorothiazide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Tetrahydroisoquinolines
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
Excipients
Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.
Drug Information Services
Services providing pharmaceutic and therapeutic drug information and consultation.
Pamphlets
Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Patient Education as Topic
The teaching or training of patients concerning their own health needs.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Drug Industry
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Medical Records Systems, Computerized
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
Pregnancy Tests
Tests to determine whether or not an individual is pregnant.
Misoprostol
A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties.
Contraceptives, Oral
Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.
Vasectomy
Surgical removal of the ductus deferens, or a portion of it. It is done in association with prostatectomy, or to induce infertility. (Dorland, 28th ed)
Protective Devices
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Diclofenac
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Ovulation Detection
Method to determine the occurrence of OVULATION by direct or indirect means. Indirect methods examine the effects of PROGESTERONE on cervical mucus (CERVIX MUCUS), or basal body temperature. Direct ovulation detection, generally used in fertility treatment, involves analyses of circulating hormones in blood and ULTRASONOGRAPHY.
Bumetanide
A sulfamyl diuretic.
Physician-Patient Relations
The interactions between physician and patient.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Phytotherapy
Use of plants or herbs to treat diseases or to alleviate pain.
Drugs, Chinese Herbal
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
United States
Universal Precautions
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.

Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis. (1/98)

BACKGROUND: The renin-angiotensin system is thought to be involved in the progression of glomerulonephritis (GN) into end-stage renal failure (ESRF) because of the observed renoprotective effects of angiotensin-converting enzyme inhibitors (ACEIs). However, ACEIs have pharmacological effects other than ACE inhibition that may help lower blood pressure and preserve glomerular structure. We previously reported a new animal model of progressive glomerulosclerosis induced by a single intravenous injection of an anti-Thy-1 monoclonal antibody, MoAb 1-22-3, in uninephrectomized rats. Using this new model of progressive GN, we examined the hypothesis that ACEIs prevent the progression to ESRF by modulating the effects of angiotensin II (Ang II) on the production of transforming growth factor-beta (TGF-beta) and extracellular matrix components. METHODS: We studied the effect of an ACEI (cilazapril) and an Ang II type 1 receptor antagonist (candesartan) on the clinical features and morphological lesions in the rat model previously reported. After 10 weeks of treatment with equihypotensive doses of cilazapril, cilazapril plus Hoe 140 (a bradykinin receptor B2 antagonist), candesartan, and hydralazine, we examined systolic blood pressure, urinary protein excretion, creatinine clearance, the glomerulosclerosis index, and the tubulointerstitial lesion index. We performed a semiquantitative evaluation of glomerular immunostaining for TGF-beta and collagen types I and III by immunofluorescence study and of these cortical mRNA levels by Northern blot analysis. RESULTS: Untreated rats developed massive proteinuria, renal dysfunction, and severe glomerular and tubulointerstitial injury, whereas uninephrectomized control rats did not. There was a significant increase in the levels of glomerular protein and cortical mRNA for TGF-beta and collagen types I and III in untreated rats. Cilazapril and candesartan prevented massive proteinuria, increased creatinine clearance, and ameliorated glomerular and tubulointerstitial injury. These drugs also reduced levels of glomerular protein and cortical mRNA for TGF-beta and collagen types I and III. Hoe 140 failed to blunt the renoprotective effect of cilazapril. Hydralazine did not exhibit a renoprotective effect. CONCLUSION: These results indicate that ACEIs prevent the progression to ESRF by modulating the effects of Ang II via Ang II type 1 receptor on the production of TGF-beta and collagen types I and III, as well as on intrarenal hemodynamics, but not by either increasing bradykinin activity or reducing blood pressure in this rat model of mesangial proliferative GN.  (+info)

Quality of life in chronic heart failure: cilazapril and captopril versus placebo. Cilazapril-Captopril Multicentre Group. (2/98)

OBJECTIVE: To measure quality of life (QOL) in patients with mild to moderate heart failure treated with angiotensin converting enzyme (ACE) inhibitors cilazapril or captopril. DESIGN: Randomised, double blind, placebo controlled, parallel groups trial. SUBJECTS: 367 patients with New York Heart Association (NYHA) heart failure class II (62%), III (36%) or IV (1%). METHODS: Patients were randomised to receive cilazapril 1 mg daily (n = 191) or captopril 25 mg three times daily (n = 90) for 24 weeks, or placebo for 12 weeks followed by cilazapril 1 mg daily for a further 12 weeks (n = 86). If patients had not responded after four weeks cilazapril was increased to 2.5 mg daily and captopril to 50 mg three times daily. QOL was assessed at baseline, 12, and 24 weeks using the sickness impact profile (SIP), the profile of mood states (POMS), the Mahler index of dyspnoea-fatigue, and a health status index (HSI). RESULTS: The physical dimension of the SIP averaged 7 units at baseline and improved after 12 weeks by 2.24 units in the cilazapril group, 2.38 units in the captopril group, and 1.51 units in the placebo group. The difference between drug and placebo was therefore 0.73 units (95% CI -0.86 to 2.32) for cilazapril, and 0.87 units (95% CI -0.96 to 2.70) for captopril, with small non-significant effect sizes (a statistical method for estimating the importance of a treatment related change) of 0.12 and 0.14. Similar results were observed for the total POMS and HSI scores. Although QOL improved more on the ACE inhibitors than on placebo, the effect sizes were not significant (< or = 0.26). CONCLUSIONS: Improvements in QOL in mild to moderate heart failure were small when treated with cilazapril or captopril compared with placebo.  (+info)

Effects of candesartan and cilazapril on rats with myocardial infarction assessed by echocardiography. (3/98)

The purpose of this study was to compare the angiotensin II type 1 receptor antagonist candesartan cilexitil (candesartan) and the angiotensin-converting enzyme inhibitor cilazapril on cardiac function, assessed by Doppler echocardiography and cardiac gene expression associated with cardiac remodeling, in rats with myocardial infarction. Candesartan or cilazapril was administered after myocardial infarction. At 1 and 4 weeks after myocardial infarction, cardiac function and mRNA expression in noninfarcted myocardium were analyzed. Candesartan and cilazapril equally prevented increases in hypertrophy in noninfarcted myocardium, left ventricular dilatation, and ejection fraction at 4 weeks. The E-wave/A-wave velocity ratio and the rate of E-wave deceleration, measures of diastolic function, increased to 9.2+/-0.6 and 26.3+/-2. 6 m/s2 at 1 week after myocardial infarction. Candesartan and cilazapril, administered at a dose of 1 mg/kg per day, prevented increases in E-wave/A-wave velocity ratio and E-wave deceleration at 1 and 4 weeks. Candesartan and cilazapril significantly suppressed increased mRNA expression of beta-myosin heavy chain, alpha-skeletal actin, and atrial natriuretic peptide in noninfarcted ventricle at 1 and 4 weeks and expression of collagen I and III at 4 weeks to a similar extent. When given at a dose of 10 mg/kg per day, both candesartan and cilazapril prevented cardiac dysfunction and gene expression to the same extent as when given at 1 mg/kg per day. In conclusion, Doppler echocardiography showed that candesartan and cilazapril equally improved systolic and diastolic function and that ventricular remodeling accompanied modulation of cardiac gene expression.  (+info)

Angiotensin-converting enzyme inhibition and AT1 receptor blockade modify the pressure-natriuresis relationship by additive mechanisms in rats with human renin and angiotensinogen genes. (4/98)

The intrarenal factors responsible for hypertension in double-transgenic rats (dTGR) harboring human renin and human angiotensinogen genes are unclear. The pressure-natriuresis and -diuresis relationships in response to chronic angiotensin-converting enzyme (ACE) inhibition and AT1 receptor blockade were evaluated. Renal renin-angiotensin and nitric oxide (NO) system gene expression was also investigated. Six-week-old dTGR were treated for 3 wk with submaximal doses of cilazapril (10 mg/kg, orally) or losartan (10 mg/kg, orally) or with the drug combination. In untreated dTGR, pressure-natriuresis relationships were maximally shifted rightward by approximately 70 to 80 mmHg, and both renal blood flow (RBF) and GFR were markedly decreased. Submaximal cilazapril and losartan dosages both decreased systolic BP by 30 mmHg and shifted the pressure-natriuresis curves leftward by 25 to 30 mmHg. Cilazapril increased RBF and GFR to values observed in normotensive control animals but did not significantly affect fractional sodium excretion (FENa) or fractional water excretion (FEH2O) curves. In contrast, losartan had no significant effect on RBF or GFR but shifted the FENa and FEH2O curves leftward. The cilazapril and losartan combination completely normalized BP and shifted the pressure-natriuresis curves leftward more than did either drug alone. When cilazapril and losartan were administered at higher doses (30 mg/kg, orally), the two drugs equally shifted the pressure-natriuresis curves leftward, by 50 mmHg. Both drugs increased RBF and GFR; however, only losartan shifted FENa and FEH2O curves leftward. Human and rat renin and angiotensinogen genes were downregulated in dTGR and were increased by losartan and cilazapril treatments, whereas no changes in the expression of rat ACE and AT1A receptor genes were observed. Endothelial NO synthase expression was increased by cilazapril but not by losartan. Neither inducible NO synthase nor neural NO synthase gene expression was affected by drug treatments. Therefore, submaximal ACE inhibition enhanced sodium excretion mainly by increasing RBF and GFR, whereas submaximal AT1 receptor blockade decreased tubular sodium and water reabsorption. The combination of the two drugs produced an additive effect. The ACE inhibitor effects may involve increased endothelial NO synthase expression, perhaps related to the inhibition of bradykinin degradation.  (+info)

Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats. (5/98)

Hepatocyte growth factor (HGF) is a unique growth factor that has many protective functions against renal damage. Our previous study demonstrated that HGF stimulated the growth of endothelial and epithelial cells without the replication of mesangial cells. Moreover, angiotensin (Ang) II significantly decreased local HGF production in mesangial cells. Therefore, we examined the effects of Ang II blockade on renal HGF expression and renal damage in experimental hypertensive rats. An angiotensin-converting enzyme inhibitor (cilazapril; 10 mg. kg(-1). d(-1)), an Ang II type 1 receptor antagonist (E-4177; 30 mg. kg(-1). d(-1)), hydralazine (8 mg. kg(-1). d(-1)), and vehicle were administered to 16-week-old stroke-prone spontaneously hypertensive rats (SHR-SP) for 3 weeks. Renal damage was evaluated with a computer analysis system, and renal HGF mRNA was measured by Northern blot analysis. Blood pressure of SHR-SP was significantly decreased by all drug treatments compared with vehicle. Moreover, cilazapril, E-4177, and hydralazine significantly decreased the thickening and necrosis of blood vessels compared with vehicle. Similarly, degeneration and necrosis of glomeruli were also markedly improved by cilazapril and E-4177 (P<0.01). We next examined the effects of Ang II blockade on renal HGF expression in SHR-SP. Renal HGF mRNA was markedly decreased in SHR-SP compared with Wistar-Kyoto rats, although Ang II blockade by cilazapril and E-4177 but not hydralazine significantly increased renal HGF mRNA in SHR-SP. Ang II blockade significantly increased renal HGF (a protective growth factor for tubular epithelial cells); thus, we examined tubular histological appearance. Degeneration and necrosis of tubules were significantly improved by cilazapril and E-4177 treatment (P<0.01). In addition, cell infiltration into the glomeruli and hemorrhage were also significantly reduced in SHR-SP treated with cilazapril or E-4177. The present data demonstrated the prevention of renal damage by Ang II blockade in SHR-SP, which was accompanied by a significant increase in renal HGF mRNA. Given the strong mitogenic activity and antiapoptotic actions of HGF on endothelial and epithelial cells, we believe that increased local HGF production by the blockade of Ang II may improve renal function in hypertension.  (+info)

Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: role of intrarenal bradykinin. (6/98)

The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation of renal afferent (AFF) and efferent arterioles (EFF) in vivo, and further evaluated whether ACEI-stimulated bradykinin activity differed in superficial (SP) and juxtamedullary nephrons (JM). Arterioles of canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 microg/kg) dilated AFF and EFF in SP (15 +/- 3% and 19 +/- 5%) and JM (15 +/- 3% and 18 +/- 4%). Subsequently, cilazaprilat (30 microg/kg) caused further dilation of both AFF (29 +/- 4%) and EFF (36 +/- 4%) in JM, whereas in SP it dilated only EFF (29 +/-3%). Similarly, in the presence of E4177, cilazaprilat caused further increases in sodium excretion. This cilazaprilat-induced vasodilation and natriuresis was abolished by a bradykinin antagonist (N(alpha)-adamantaneacetyl-D-Arg-[Hyp3,Thi5,8,D-Phe7]b radykinin). In parallel with these results, cilazaprilat increased renal bradykinin content, more greatly in the medulla than in the cortex (5.7 +/- 0.4 versus 4.6 +/- 0.1 ng/g). Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. In conclusion, zonal heterogeneity in renal bradykinin/nitric oxide levels and segmental differences in reactivity to bradykinin contribute to the diverse responsiveness of renal AFF and EFF to ACEI. ACEI-enhanced kinin action would participate in the amelioration of glomerular hemodynamics and renal sodium excretion by ACEI.  (+info)

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. (7/98)

In renal extracts, some renin is present as "high molecular weight renin," a heterodimeric complex of renin with the 46-kDa renin-binding protein (RnBP), also known as N-acyl-D-glucosamine 2-epimerase. Because RnBP specifically inhibits renin activity, the protein was proposed to play an important role in the regulation of the renin-angiotensin system (RAS). Using gene targeting, we have generated mice lacking RnBP and tested this hypothesis in vivo. In particular, we analyzed biosynthesis, secretion, and activity of renin and other components of the RAS in mice lacking RnBP. Despite extensive investigations, we were unable to detect any major effects of RnBP deficiency on the plasma and renal RAS or on blood pressure regulation. Contrary to previous hypotheses, we conclude that RnBP does not play a significant role in the regulation of renin activity in plasma or kidney. However, RnBP knockout mice excrete an abnormal pattern of carbohydrates in the urine, indicating a role of the protein in renal carbohydrate metabolism.  (+info)

Long-term effect of angiotensin-converting enzyme inhibitor in volume overloaded heart during growth: a controlled pilot study. (8/98)

OBJECTIVES: This study examined whether long-term therapy with an angiotensin-converting enzyme (ACE) inhibitor reduces excessive increases in left ventricular (LV) mass as well as volume in growing children with aortic regurgitation or mitral regurgitation. BACKGROUND: The ACE inhibitor reduces volume overload and LV hypertrophy in adults with aortic or mitral regurgitation. METHODS: This study included 24 patients whose ages ranged from 0.3 to 16 years at entry to the study. On echocardiography, we measured LV size, systolic function and mass. After obtaining baseline data, patients were allocated into two groups. Twelve patients were given an ACE inhibitor (ACE inhibitor group), and 12 patients were not (control group). Echo parameters were again assessed after an average 3.4 years of follow-up. RESULTS: Left ventricular parameters at baseline in the two groups were similar. The Z value of LV end-diastolic dimensions decreased from +0.82 +/- 0.55 to +0.57 +/- 0.58 in the ACE inhibitor group, whereas it increased from +0.73 +/- 0.85 to +1.14 +/- 1.04 in the control group (mean change -0.25 +/- 0.33 for the ACE inhibitor group vs. +0.42 +/- 0.48 for the control group, p = 0.0007). The mass normalized to growth also reduced from 221 +/- 93% to 149 +/- 44% of normal in the ACE inhibitor group and increased from 167 +/- 46% to 204 +/-59% of normal in the control group (mean change -72 +/- 89% of normal for the ACE inhibitor group vs. +37 +/- 35% of normal for the control group, p = 0.0007). CONCLUSIONS: Long-term treatment with ACE inhibitors is effective in reducing not only LV volume overload but also LV hypertrophy in the hearts of growing children with LV volume overload.  (+info)

Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary...Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary...
METHODS AND RESULTS We conducted a randomized, double-blind placebo-controlled trial to assess the effect of cilazapril in angiographic restenosis prevention after percutaneous transluminal coronary angioplasty (PTCA). Patients received cilazapril 2.5 mg in the evening after successful PTCA and 5 mg b.i.d. for 6 months or matched placebo. In addition, all patients received aspirin for 6 months. Coronary angiograms before PTCA, after PTCA, and at 6-month follow-up were quantitatively analyzed. In 94% of 735 recruited patients, PTCA was successful and all inclusion and exclusion criteria were met. For the per-protocol analysis, quantitative angiography after PTCA and at follow-up was available in 595 patients who complied with the treatment regimen (309 control, 286 cilazapril). The mean difference in minimal coronary lumen diameter between post-PTCA and follow-up angiogram (primary end point) was -0.29 +/- 0.49 mm in the control group and -0.27 +/- 0.51 mm in the cilazapril group. Clinical events ...
http://circ.ahajournals.org/content/86/1/100
Cilazapril by Sanis - PharmasaveCilazapril by Sanis - Pharmasave
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.. Angioedema: Angioedema is a serious allergic reaction that causes the area around the face, throat, and tongue to swell. It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once and get immediate medical attention. Do not take other ACE inhibitors in the future. If you have had angioedema caused by other substances, you may be at increased risk of angioedema while receiving cilazapril.. Cough: ACE inhibitors such as this medication may cause you to develop a dry, persistent cough within hours of the first dose to weeks or months after starting therapy. The cough usually resolves within 4 weeks of stopping this medication. ...
http://www.pharmasave.com/medications/cilazapril-by-sanis/
Cilazapril Sanis Health - Drugs.comCilazapril Sanis Health - Drugs.com
Cilazapril Sanis Health is a medicine available in a number of countries worldwide. A list of US medications equivalent to Cilazapril Sanis Health is available on the Drugs.com website.
https://www.drugs.com/international/cilazapril-sanis-health.html
Cilazapril | Springer for Research & DevelopmentCilazapril | Springer for Research & Development
Synopsis Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. Like enalapril and ramipril it is a...
https://rd.springer.com/article/10.2165/00003495-199141050-00008
RxHealthMedRxHealthMed
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Angioedema: Angioedema is a serious allergic reaction that causes the area around the face, throat, and tongue to swell. It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once and get immediate medical attention. Do not take other ACE inhibitors in the future. If you have had angioedema caused by other substances, you may be at increased risk of angioedema while receiving cilazapril.. Cough: ACE inhibitors such as this medication may cause you to develop a dry, persistent cough within hours of the first dose to weeks or months after starting therapy. The cough usually resolves within 4 weeks of stopping this medication. ...
http://www.rxhealthmed.ca/health-advice/medication-search/med/4075
Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats<...Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats<...
TY - JOUR. T1 - Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats. AU - Toyoda, Kazunori. AU - Fujii, Kenichiro. AU - Ibayashi, Setsuro. AU - Kitazono, Takanari. AU - Nagao, Tetsuhiko. AU - Takaba, Hitonori. AU - Fujishima, Masatoshi. PY - 1998/3. Y1 - 1998/3. N2 - Cerebral large arteries dilate actively around the lower limits of CBF autoregulation, mediated at least partly by nitric oxide, and maintain CBF during severe hypotension. We tested the hypothesis that this autoregulatory response of large arteries, as well as the response of arterioles, is altered in spontaneously hypertensive rats (SHR) and that the altered response reverts to normal during long-term antihypertensive treatment with cilazapril, an angiotensin-converting enzyme inhibitor. In anesthetized 6- to 7-month-old normotensive Wistar-Kyoto rats (WKY), 4- and 6- to 7-month-old SHR without antihypertensive treatment, and 6- to 7-month-old SHR treated with cilazapril for 10 weeks, local CBF ...
https://kyushu-u.pure.elsevier.com/en/publications/attenuation-and-recovery-of-brain-stem-autoregulation-in-spontane
Inhibace Plus - Uses, Side Effects, Interactions - Canada.comInhibace Plus - Uses, Side Effects, Interactions - Canada.com
Inhibace Plus: This combination product contains two active medications: cilazapril and hydrochlorothiazide. Cilazapril belongs to the class of medications called ACE inhibitors. It works by relaxing blood vessels and helping the heart to pump blood that carries oxygen to the different parts of the body more efficiently. Hydrochlorothiazide belongs to the class of medications called thiazide diuretics or water pills, which help control blood pressure by getting rid of excess salt and water.
http://bodyandhealth.canada.com/drug/getdrug/inhibace-plus
Inhibace - Uses, Side Effects, Interactions - MedBroadcast.comInhibace - Uses, Side Effects, Interactions - MedBroadcast.com
Inhibace: Cilazapril belongs to the family of medications known as angiotensin converting enzyme (ACE) inhibitors. It is used to treat mild-to-moderate high blood pressure and congestive heart failure (CHF). Cilazapril controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and making the heart pump more efficiently.
http://www.medbroadcast.com/drug/getdrug/inhibace
1992 - Nifedipine had a more negative effect on quality of life than cilazapril or atenolol | 1992 Nov-Dec : Volume...1992 - Nifedipine had a more negative effect on quality of life than cilazapril or atenolol | 1992 Nov-Dec : Volume...
Few large trials have evaluated the relative efficacy of different antihypertensive agents in decreasing cardiovascular events, and it is generally accepted that most agents have roughly equivalent efficacy in their blood pressure-lowering effects. Many experts recommend, therefore, that drug selection be based on comorbid profiles of patients, metabolic neutrality, ability to retard left ventricular hypertrophy, and costs and side effects of individual medications. A burgeoning literature, including the article by Fletcher and colleagues, addresses the latter important issue of potential differences in quality of life and side effects among various agents. The principal findings of little to no differences in measurements of quality of life, but increased symptom reporting leading to more frequent discontinuation of nifedipine, are consonant with earlier findings. They are not, however, necessarily generalizable to other calcium channel-blocking agents. Other than documenting more side effects ...
http://acpjc.org/Content/117/3/issue/ACPJC-1992-117-3-081.htm
Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart...Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart...
To discover the underlying mechanisms involved in the beneficial long-term effects of angiotensin converting enzyme (ACE) inhibitors, we investigated the systemic and peripheral effects of short- and long-term ACE inhibition in patients with chronic heart failure. After assessing the short-term effects and dose titration with cilazapril, a new long-acting ACE inhibitor, 21 patients were randomized to receive either placebo or the ACE inhibitor. Seventeen patients completed the 3-month treatment. Central hemodynamic output, femoral blood flow (measured by thermodilution), oxygen saturation, and lactate and norepinephrine levels were determined simultaneously in the femoral vein and radial artery during treatment and after a 3-month rest and during symptom-limited bicycle exercise. Short-term ACE inhibition improved rest and exercise hemodynamic output, but it did not alter peak femoral blood flow, calculated leg oxygen consumption, or systemic oxygen uptake during exercise, despite significant ...
http://circ.ahajournals.org/content/79/3/491
INHIBACE 5 mg filmtablettaINHIBACE 5 mg filmtabletta
1. Milyen t pus gy gyszer az Inhibace s milyen betegs gek eset n alkalmazhat ?Az Inhibace hat anyaga a cilazapril.Az Inhibace-t az al bbiak kezel s re alkalma
https://www.hazipatika.com/gyogyszerkereso/termek/inhibace_5_mg_filmtabletta/816
INHIBACE 2,5 mg filmtablettaINHIBACE 2,5 mg filmtabletta
1. Milyen t pus gy gyszer az Inhibace s milyen betegs gek eset n alkalmazhat ?Az Inhibace hat anyaga a cilazapril.Az Inhibace-t az al bbiak kezel s re alkalma
https://www.hazipatika.com/gyogyszerkereso/termek/inhibace_25_mg_filmtabletta/815
Procuring cilazapril demands substantial alprazolamProcuring cilazapril demands substantial alprazolam
cilazapril hydrochloride capsules and alprazolam tablets should be partly used cautiously used in patients receiving concomitant therapy training with other antihypertensives. Quinapril hydrochloride/hydrochlorothiazide, containing hydrochlorothiazide, is still available as OTC upon examining your request to the pharmacist, at
http://thecollectibleornamentshoppe.com/nesacaine-ce-3-inj-30mg-ml-bristol-myers-squibb-familybusiness-my.html
Bactrim pediatric oral suspension / Synthroid hair loss reversibleBactrim pediatric oral suspension / Synthroid hair loss reversible
Bactrim®) - Résumé des caractéristiques du. Stability of cilazapril in pediatric oral suspensions prepared from commercially available tablet dosage.. Side effects anxiety teeth infection how long to wait to drink alcohol after bactrim forte dosage for the elderly oral. bactrim pediatric dose suspension.What is the use of 500 mg given to babies over the counter bactrim for acne do cvs sell. Ointment advantage of tablets over suspension azithromycin coverage.Oral suspension children ds and hiv sumatriptan generico. in the sun when taking long until bactrim starts working bactrim 400 80 mg roche pediatric dosing.Side effect to how long after can I drink pediatric clarithromycin. myeloma difference between and bactrim h pylori. be taken with milk oral suspension ...
http://boobsandloops.tk/rumu/bactrim-pediatric-oral-suspension-379.php
Use of PDE III Inhibitors for the Treatment of Asymptomatic (Occult) Heart Failure - Patent applicationUse of PDE III Inhibitors for the Treatment of Asymptomatic (Occult) Heart Failure - Patent application
in particular [0043]wherein the calcium channel blocker inhibitor is selected from the group consisting of diltiazem, verapamil and felodipine or a pharmaceutically acceptable derivative thereof; and/or [0044]wherein the ACE inhibitor is selected from the group consisting of omapatrilat, MDL100240, alacepril, benazepril, captopril, cilazapril, delapril, enalapril, enalaprilat, fosinopril, fosinoprilat, imidapril, lisinopril, perindopril, quinapril, ramipril, ramiprilat, saralasin acetate, temocapril, trandolapril, trandolaprilat, ceranapril, moexipril, quinaprilat and spirapril or a pharmaceutically acceptable derivative thereof; and/or [0045]wherein the beta blocker is selected from the group consisting of bisoprolol, carvediol, metoprolol, propranolol and timolol or a pharmaceutically acceptable derivative thereof, and/or [0046]wherein the angiotensin II antagonist is selected from the group consisting of saralasin acetate, candesartan, cilexetil, valsartan, candesartan, losartan potassium, ...
http://www.patentsencyclopedia.com/app/20100273807
Levaquin used to treat stdsLevaquin used to treat stds
By contrast, blue cross blue shield of priligy online apotheke healthcare pharmacy revenues... Levaquin iv interactions... S... Lamisil cream for fungal nail infection... Propecia buy usa... Cilazapril 5mg + hydrochlorothiazide 12.5 mg tablet... Estrace tablets forum... Motrin infant dosage... Cleocin ovules and alcohol...
https://www.centrospecialisticosanmartino.it/levaquin+used+to+treat+stds/
Fasting May Increase Motivation to Exercise - Naturopathic Doctor News and ReviewFasting May Increase Motivation to Exercise - Naturopathic Doctor News and Review
Results revealed that both groups of mice ate the same amounts of food but the restricted group ran more on the wheel compared to the mice that were allowed to food all day. In another part of the experiment, the team genetically altered the mice so that they did not produce any ghrelin (ghrelin knocks out mice). When these mice were put on a restricted and limited diet, they did not run more. This proved that ghrelin was responsible for making the mice on restricted feeding run more, explained the researchers.. Authors wrote, The plasma ghrelin concentration fluctuates throughout the day with its peak at the beginning of the dark period in the wild type (WT) mice with voluntary exercise. Although predominant increases in wheel running activity were observed accordant to the peak of plasma ghrelin concentration in the WT mice, those were severely attenuated in the ghrelin knockout (GKO) mice under either ad libitum or time-restricted feeding.. When ghrelin was administered to these genetically ...
https://ndnr.com/naturopathic-news/fasting-may-increase-motivation-to-exercise/
Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac β-Adrenergic Signal...Effects of Angiotensin II Type 1 Receptor Blockade and Angiotensin-Converting Enzyme Inhibition on Cardiac β-Adrenergic Signal...
β-Adrenergic desensitization has been suggested to represent an important mechanism of contractile dysfunction in heart failure.11 12 13 14 15 16 The diminished formation of the second-messenger cAMP after stimulation of cardiac β-adrenergic receptors is due to a decline in the number of β-adrenergic receptors,11 12 13 an uncoupling of β-adrenergic receptors, and an increase in inhibitory G protein α subunits.14 15 16 The underlying mechanism inducing these desensitization processes is an activation of the sympathetic nervous system and, in particular, sympathetic activation in the heart itself.2 Several reports indicate that β-adrenergic neuroeffector defects occur not only in terminal heart failure but also in hypertensive heart disease.37 These data have been obtained in rat models of hypertensive heart disease (eg, spontaneously hypertensive rats38 39 ), rat models of acquired forms of hypertension (eg, reduced renal mass,40 renal artery banding,40 41 and deoxycorticosterone ...
http://hyper.ahajournals.org/content/31/3/747
DailyMed - UNIVASC- moexipril hydrochloride tablet, film coatedDailyMed - UNIVASC- moexipril hydrochloride tablet, film coated
Single and multiple doses of 15 mg or more of univasc ® gives sustained inhibition of plasma ACE activity of 80-90%, beginning within 2 hours and lasting 24 hours (80%). In controlled trials, the peak effects of orally administered moexipril increased with the dose administered over a dose range of 7.5 to 60 mg, given once a day. Antihypertensive effects were first detectable about 1 hour after dosing, with a peak effect between 3 and 6 hours after dosing. Just before dosing (i.e., at trough), the antihypertensive effects were less prominently related to dose and the antihypertensive effect tended to diminish during the 24-hour dosing interval when the drug was administered once a day.. In multiple dose studies in the dose range of 7.5 to 30 mg once daily, univasc ® lowered sitting diastolic and systolic blood pressure effects at trough by 3 to 6 mmHg and 4 to 11 mmHg more than placebo, respectively. There was a tendency toward increased response with higher doses over this range. These ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e16c2ad3-1ce5-48fc-96b2-5d63dc6b68d5
Invertase Suc2-mediated inulin catabolism is regulated at the transcript level in Saccharomyces cerevisiae | Microbial Cell...Invertase Suc2-mediated inulin catabolism is regulated at the transcript level in Saccharomyces cerevisiae | Microbial Cell...
Invertase Suc2 (EC 3.2.1.26) belongs to sucrose-hydrolyzing enzyme but plays a key role in inulin catabolism by catalyzing inulin hydrolysis in yeast S. cerevisiae [10]. However, the inulinase activity of Suc2 can be detected only in some S. cerevisiae strains although SUC2 is a constitutive genomic component [16]. As shown in Figure 1, all strains L610, NCYC625 and BY4741 could grow well in the inulin medium, whereas the Suc2 activity and ethanol production in strain L610 is much higher than that in strains NCYC625 and BY4741. It is presumed that biomass and ethanol production of strains NCYC625 and BY4741 is mainly from the residual glucose and fructose in the inulin medium but not from inulin (Figure 3B). In fact, a little inulin was catabolised by strain BY4741 compared with strain L610 after incubation in inulin medium for 48 h (Figure 3B). Therefore, both strains NCYC625 and BY4741 could weakly catabolize inulin and strain L610 could strongly utilize inulin for ethanol production.. It has ...
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-015-0243-3
Tissue Angiotensin-Converting-Enzyme (ACE) Deficiency Leads to a Reduction in Oxidative Stress and in Atherosclerosis |...Tissue Angiotensin-Converting-Enzyme (ACE) Deficiency Leads to a Reduction in Oxidative Stress and in Atherosclerosis |...
This study demonstrates that knockout of the ACE gene in mice caused a decrease in lipid peroxide content in their sera and peritoneal macrophages. Injection of Ang II into ACE+/− mice increased macrophage lipid peroxidation and the macrophages ability to oxidize LDL to levels similar to those found in ACE+/+ mice. Crossbreeding of E0 mice with the ACE+/− mice resulted in offspring homozygous for APOE and heterozygous for ACE, and these animals exhibited decreased atherogenesis compared with E0 mice. These mice demonstrated significant reduced serum, macrophage, and aortic oxidative stress compared with E0 mice. Most important, reduced oxidative stress in ACE+/−/E0 mice was associated with reduced atherosclerotic lesion area compared with age-matched, E0 mice.. In this study, we used a model of knockout mouse, the ACE-knockout mouse type-2,20 which expresses a truncated form of somatic ACE and thus, exhibits reduced plasma ACE activity but completely lacks tissue ACE. The use of ...
http://atvb.ahajournals.org/content/23/11/2090.full
Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa in: European Journal of...Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa in: European Journal of...
OBJECTIVE: Ghrelin is a new gastric hormone that has been identified as an endogenous ligand for the growth hormone (GH) secretagogue receptor subtype 1a (GHS-R1a). Ghrelin administration however not only stimulates GH secretion but also induces adiposity in rodents by increasing food intake and decreasing fat utilization. We hypothesized that impaired ghrelin secretion in anorexia nervosa may be involved in the pathogenesis of this eating disorder. To examine this hypothesis and to further investigate the role for ghrelin in regulating energy homeostasis, we analyzed circulating ghrelin levels in patients with anorexia nervosa and examined possible correlations with clinical parameters before and after weight gain. METHODS: Plasma ghrelin levels were measured in overnight fasting plasma samples from 36 female patients with anorexia nervosa (age: 25.0+/-1.2 years, BMI: 15.2+/-0.2 kg/m(2)) before and after weight gain following psychotherapeutic treatment intervention in a psychosomatic ...
https://eje.bioscientifica.com/abstract/journals/eje/145/5/669.xml
Additional Possibility of Data Analysis of Enzyme Inhibition and Activation. 8. A Choice of the Equations for Calculation of...Additional Possibility of Data Analysis of Enzyme Inhibition and Activation. 8. A Choice of the Equations for Calculation of...
Fulltext - Additional Possibility of Data Analysis of Enzyme Inhibition and Activation. 8. A Choice of the Equations for Calculation of the Initial Reaction Rates vi and va in Enzyme Inhibition and Activation
https://scialert.net/fulltext/?doi=jbs.2007.506.513
Hoffmann-La RocheHoffmann-La Roche
Inhibace (cilazapril), for hypertension and congestive heart failure. Invirase (saquinavir), for HIV-1 infection. Kadcyla ( ...
https://en.wikipedia.org/wiki/Hoffmann-La_Roche
OmapatrilatOmapatrilat
Gemopatrilat Cilazapril Sacubitril "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended ...
https://en.wikipedia.org/wiki/Omapatrilat
ACE inhibitorACE inhibitor
Cilazapril (Inhibace). Phosphonate-containing agentsEdit. *Fosinopril (Fositen/Monopril) is the only member of this group ...
https://en.m.wikipedia.org/wiki/ACE_inhibitors
Natural productNatural product
... was a lead in the development of the antihypertensive agents cilazapril and captopril. Also, echistatin, a disintegrin from the ...
https://en.wikipedia.org/wiki/Natural_product
List of MeSH codes (D03)List of MeSH codes (D03)
... cilazapril MeSH D03.383.710.350 - luminol MeSH D03.383.710.400 - maleic hydrazide MeSH D03.383.710.605 - phthalazines MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
List of drugs: CiList of drugs: Ci
... cilazapril (INN) cilazaprilat (INN) cilengitide (USAN) cilmostim (INN) cilnidipine (INN) cilobamine (INN) cilobradine (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Ci
ATC code C09ATC code C09
... diuretics C09BA05 Ramipril and diuretics C09BA06 Quinapril and diuretics C09BA07 Benazepril and diuretics C09BA08 Cilazapril ... Enalapril C09AA03 Lisinopril C09AA04 Perindopril C09AA05 Ramipril C09AA06 Quinapril C09AA07 Benazepril C09AA08 Cilazapril ...
https://en.wikipedia.org/wiki/ATC_code_C09
CilazaprilCilazapril
... is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive ... Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 Suppl 1: 18-24. doi:10.2165/00003495-199100411-00005. PMID 1712267. Jasek, ... "Cilazapril". Drugs.com. Retrieved 28 May 2010. v t e. ...
https://en.wikipedia.org/wiki/Cilazapril
CaptoprilCaptopril
In the late 1960s, John Vane of the Royal College of Surgeons of England was working on mechanisms by which the body regulates blood pressure.[13] He was joined by Sérgio Henrique Ferreira of Brazil, who had been studying the venom of a Brazilian pit viper, the jararaca (Bothrops jararaca), and brought a sample of the viper's venom. Vane's team found that one of the venom's peptides selectively inhibited the action of angiotensin-converting enzyme (ACE), which was thought to function in blood pressure regulation; the snake venom functions by severely depressing blood pressure. During the 1970s, ACE was found to elevate blood pressure by controlling the release of water and salts from the kidneys. Captopril, an analog of the snake venom's ACE-inhibiting peptide, was first synthesized in 1975 by three researchers at the U.S. drug company E.R. Squibb & Sons Pharmaceuticals (now Bristol-Myers Squibb): Miguel Ondetti, Bernard Rubin, and David Cushman. Squibb filed for U.S. patent protection on the ...
https://en.wikipedia.org/wiki/Captopril
Losartan/hydrochlorothiazideLosartan/hydrochlorothiazide
... , sold under the trade name Hyzaar among others, is a combination medication used to treat high blood pressure when losartan is not sufficient.[1] It consists of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a diuretic).[1] It is taken by mouth.[1] Common side effects include dizziness, back pain, and upper respiratory tract infections.[2] Serious side effects may include low blood pressure, kidney problems, allergic reactions, and electrolyte problems.[2] Use in pregnancy and breastfeeding is not recommended.[3] Losartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes.[2] Interactions include with lithium, agents which increase potassium, and NSAIDs.[2] The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[1] A month supply in the United Kingdom costs the NHS about 1.50 £ per ...
https://en.wikipedia.org/wiki/Hyzaar
Renin-angiotensin systemRenin-angiotensin system
Locally expressed renin-angiotensin systems have been found in a number of tissues, including the kidneys, adrenal glands, the heart, vasculature and nervous system, and have a variety of functions, including local cardiovascular regulation, in association or independently of the systemic renin-angiotensin system, as well as non-cardiovascular functions.[7][9][10] Outside the kidneys, renin is predominantly picked up from the circulation but may be secreted locally in some tissues; its precursor prorenin is highly expressed in tissues and more than half of circulating prorenin is of extrarenal origin, but its physiological role besides serving as precursor to renin is still unclear.[11] Outside the liver, angiotensinogen is picked up from the circulation or expressed locally in some tissues; with renin they form angiotensin I, and locally expressed angiotensin-converting enzyme, chymase or other enzymes can transform it into angiotensin II.[11][12][13] This process can be intracellular or ...
https://en.wikipedia.org/wiki/RAA_system
Angiotensin II receptorAngiotensin II receptor
AT2 receptors are more plentiful in the fetus and neonate. The AT2 receptor remains enigmatic and controversial - is probably involved in vascular growth. Effects mediated by the AT2 receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilation and left ventricular hypertrophy.[5] ...
https://en.wikipedia.org/wiki/Angiotensin_receptor
LisinoprilLisinopril
Ostali/negrupisani: Alacepril • Cilazapril • Delapril • Imidapril • Moeksipril • Rentiapril • Spirapril • Temokapril • ...
https://sh.wikipedia.org/wiki/Lizinopril
Cilazapril - Drugs.comCilazapril - Drugs.com
A list of US medications equivalent to Cilazapril is available on the Drugs.com website. ... Cilazapril is a medicine available in a number of countries worldwide. ... Cilazapril + Hidroclorotiazida Generis (Cilazapril and Hydrochlorothiazide). Generis, Portugal. *Cilazapril 5 Plus (Cilazapril ... Apo-Cilazapril/HCTZ (Cilazapril and Hydrochlorothiazide). Apotex, Canada. *Cazacombi (Cilazapril and Hydrochlorothiazide). Krka ...
https://www.drugs.com/international/cilazapril.html
Cilazapril - WikipediaCilazapril - Wikipedia
Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive ... Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 Suppl 1: 18-24. doi:10.2165/00003495-199100411-00005. PMID 1712267. Jasek, ... "Cilazapril". Drugs.com. Retrieved 28 May 2010. v t e. ...
https://en.wikipedia.org/wiki/Cilazapril
pms-Cilazapril - Uses, Side Effects, Interactions - MedBroadcast.compms-Cilazapril - Uses, Side Effects, Interactions - MedBroadcast.com
It is used to treat mild-to-moderate high blood pressure and congestive heart failure (CHF). Cilazapril controls blood pressure ... Cilazapril belongs to the family of medications known as angiotensin converting enzyme (ACE) inhibitors. ... 02280442 PMS-CILAZAPRIL 1MG TABLET. 02280450 PMS-CILAZAPRIL 2.5MG TABLET. 02280469 PMS-CILAZAPRIL 5MG TABLET. ... It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once ...
https://medbroadcast.com/drug/getdrug/pms-cilazapril
Teva-Cilazapril-HCTZ - Uses, Side Effects, Interactions - MedBroadcast.comTeva-Cilazapril-HCTZ - Uses, Side Effects, Interactions - MedBroadcast.com
... cilazapril and hydrochlorothiazide. Cilazapril belongs to the class of medications called ACE inhibitors. It works by relaxing ... Teva-Cilazapril-HCTZ: This combination product contains two active medications: ... Do not take cilazapril - hydrochlorothiazide if you:. *are allergic to cilazapril, hydrochlorothiazide, or any ingredients of ... This combination product contains two active medications: cilazapril and hydrochlorothiazide. Cilazapril belongs to the class ...
https://medbroadcast.com/drug/getdrug/teva-cilazapril-hctz
Cilazapril | Springer for Research & DevelopmentCilazapril | Springer for Research & Development
Synopsis Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular ... Cilazapril 2.5mg daily was similar in efficacy to propranolol slow release 120mg while cilazapril 1.25 to 2.5mg and ... Effect of cilazapril, a novel angiotensinconverting enzyme inhibitor, on the and safety of cilazapril, an inhibitor of ... Kohno M, Yasunari K, Murakawa K, Yokokawa K, Takeda T. Cilazapril: acute effects of cilazapril on hemodynamic and endocrine ...
https://rd.springer.com/article/10.2165/00003495-199141050-00008
Cilazapril by Sanis - PharmasaveCilazapril by Sanis - Pharmasave
It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once ... Cilazapril belongs to the family of medications known as angiotensin converting enzyme (ACE) inhibitors. It is used to treat ... contains anhydrous cilazapril 2.5 mg as cilazapril monohydrate. Nonmedicinal ingredients: lactose, cornstarch, microcrystalline ... contains anhydrous cilazapril 1 mg as cilazapril monohydrate. Nonmedicinal ingredients: lactose, cornstarch, microcrystalline ...
http://www.pharmasave.com/medications/cilazapril-by-sanis/
Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary...Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary...
... cilazapril, 53), or recurrent angina requiring medical therapy (control, 67; cilazapril, 68) to none of the above (control, 224 ... cilazapril, three), nonfatal myocardial infarction (control, eight; cilazapril, 5), coronary revascularization (control, 51; ... BACKGROUND Cilazapril is a novel angiotensin converting enzyme inhibitor with antiproliferative effects in the rat model after ... CONCLUSIONS Long-term angiotensin converting enzyme inhibition with cilazapril in a dose of 5 mg b.i.d. does not prevent ...
http://circ.ahajournals.org/content/86/1/100
The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart FailureThe Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure
Cilazapril Ventricular remodeling MeSH Terms expand_less. expand_more. Blood Pressure Chemistry Cilazapril Cough Dilatation ... MATERIALS AND METHODS: Cilazapril, 2.5 - 5.0 mg per day was administ-ered 12 weeks after coronary interventions in 25 patients ... Side effects of Cilazapril were 3 dry cough (3/25, 12%) and 1 facial edema, 1 hypotension and 1 dizziness. CONCLUSION: ... The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure. ...
https://koreamed.org/article/1054KCJ/1998.28.12.1964
1992 - Nifedipine had a more negative effect on quality of life than cilazapril or atenolol | 1992 Nov-Dec : Volume...1992 - Nifedipine had a more negative effect on quality of life than cilazapril or atenolol | 1992 Nov-Dec : Volume...
Nifedipine had a more negative effect on quality of life than cilazapril or atenolol. ACP J Club. 1992 Nov-Dec;117:81. doi: ... Patients were assigned to cilazapril, 2.5 mg/d; atenolol, 50 mg/d; or nifedipine, 20 mg twice daily. If DBP was , 90 mm Hg at ... The groups did not differ in mean change from baseline in DBP (cilazapril -14.7, atenolol -15.5, nifedipine -14.7 mm Hg), but ... Cilazapril, atenolol, and nifedipine were equally effective in controlling blood pressure but nifedipine was associated with ...
http://acpjc.org/Content/117/3/issue/ACPJC-1992-117-3-081.htm
Acute effects of cilazapril on coronary hemodynamics in patients with renovascular hypertension. - Semantic ScholarAcute effects of cilazapril on coronary hemodynamics in patients with renovascular hypertension. - Semantic Scholar
The performance of handgrip after cilazapril resulted in higher increases in CBF for a given increase in myocardial oxygen ... before and 60 min after 2.5 mg of oral cilazapril. The drug induced a prompt, significant decrease in mean arterial pressure ... Acute effects of cilazapril on coronary hemodynamics in patients with renovascular hypertension.. @article{Magrini1992AcuteEO, ... title={Acute effects of cilazapril on coronary hemodynamics in patients with renovascular hypertension.}, author={Fabio Magrini ...
https://www.semanticscholar.org/paper/Acute-effects-of-cilazapril-on-coronary-in-patients-Magrini-Reggiani/008616f1fab6f97eaaa8f536d81c39f82b989f31
Cilazapril | Daviss Drug GuideCilazapril | Davis's Drug Guide
Find information on Cilazapril in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... cilazapril is a sample topic from the Daviss Drug Guide. To view other topics, please sign in or purchase a subscription. ... "Cilazapril." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Nursing Central, nursing.unboundmedicine.com/ ... nursingcentral/view/Davis-Drug-Guide/109857/all/cilazapril. Quiring C, Sanoski CA, Vallerand AH. Cilazapril. Daviss Drug Guide ...
https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/109857/all/cilazapril?q=blood+pressure
Cilazapril | Daviss Drug GuideCilazapril | Davis's Drug Guide
Find information on Cilazapril in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, ... "Cilazapril." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Daviss Drug Guide - OLD - USE 2.0, www.drugguide.com/ddo/ ... view/Davis-Drug-Guide/109857/all/cilazapril. Quiring C, Sanoski CA, Vallerand AH. Cilazapril. Daviss Drug Guide. F.A. Davis ... cilazapril is a sample topic from the Daviss Drug Guide. To view other topics, please sign in or purchase a subscription. ...
https://www.drugguide.com/ddo/view/Davis-Drug-Guide/109857/all/cilazapril
Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)
The DTA curve of Cilazapril CPL shows four peaks (Figure 3). The first peak has endothermic shoulder at 63.4˚C attributed to ... Cilazapril (CPL) (Figure 1(b)) belongs to angiotensin converting enzyme (ACE) inhibitor. It is (15, 95)-9-[[(15)-1-( ... Telmisartan, Cilazapril and Terazosin HCL, which belong to different groups of antihypertensive drugs, were chosen for study. ... Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL). L. M. Al-Harbi1, E. H. El- ...
https://file.scirp.org/Html/1-2200640_34545.htm
Mylan-Cilazapril | RxHealthMedMylan-Cilazapril | RxHealthMed
It is used to treat mild-to-moderate high blood pressure and congestive heart failure (CHF). Cilazapril controls blood pressure ... Cilazapril belongs to the family of medications known as angiotensin converting enzyme (ACE) inhibitors. ... It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once ... contains anhydrous cilazapril 2.5 mg as cilazapril monohydrate. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, ...
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cilazapril | Daviss Drug Guidecilazapril | Davis's Drug Guide
cilazapril answers are found in the Daviss Drug Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and ... cilazapril is a sample topic from the Daviss Drug Guide. To view other topics, please sign in or purchase a subscription. ... "Cilazapril." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Emergency Central, emergency.unboundmedicine.com/emergency ... Davis-Drug-Guide/109857/all/cilazapril. Quiring C, Sanoski CA, Vallerand AH. Cilazapril. Daviss Drug Guide. 16th ed. F.A. ...
https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109857/all/cilazapril
Cilazapril - Alport Syndrome NewsCilazapril - Alport Syndrome News
Read about cilazapril, an ACE inhibitor that works to lower blood pressure, and can help to prevent kidney disease progression ... A total of 49 patients randomly received either cilazapril alone or cilazapril in combination with hydrochlorothiazide (a ... Cilazapril is an ACE-inhibitor used to treat high blood pressure. It is not available in the U.S., but it is used in Canada and ... Cilazapril in clinical trials. A clinical trial, results of which were published in the Archives of Endocrinology and ...
https://alportsyndromenews.com/cilazapril/
Cilazapril Usage - Galen ReasonerCilazapril Usage - Galen Reasoner
Cilazapril is a specific, long-acting angiotensin-converting enzyme (ACE) inhibitor which suppresses the renin-angiotensin- ...
https://www.galenreasoner.com/substances/cilazapril/usage
Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. - ScienceOpenCilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. - ScienceOpen
We undertook a study to determine whether therapy with cilazapril would modify the expression of PKD in the Han:SPRD-cy rat, a ... Cilazapril is a long-acting angiotensin-converting enzyme inhibitor that has been effective in producing vascular remodelling ... cilazapril-treated animals had modest but statistically significant reductions in serum creatinine (mean, 1.77 mg/dL v 1.97 mg/ ... dL; P = 0.0006) and morphometrically assessed cyst volume (mean, 0.32 mL v 0.67 mL; P = 0.036). Cilazapril is an effective ...
https://www.scienceopen.com/document?vid=f1ffa97a-1eec-47ad-8c58-212218025a55
Prilazid Plus - Drugs.comPrilazid Plus - Drugs.com
Cilazapril monohydrate (a derivative of Cilazapril) is reported as an ingredient of Prilazid Plus in the following countries:. ...
https://www.drugs.com/international/prilazid-plus.html
Procuring cilazapril demands substantial alprazolamProcuring cilazapril demands substantial alprazolam
cilazapril hydrochloride capsules and alprazolam tablets should be partly used cautiously used in patients receiving ... cilazapril hydrochloride capsules and alprazolam tablets should be partly used cautiously used in patients receiving ... This informal interaction caused to change hydrochlorothiazide and cilazapril crystalline structure to amorphous form resulting ...
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Cilazapril Coupon 2018 & 80% off Discount Card · RX24 DrugsCilazapril Coupon 2018 & 80% off Discount Card · RX24 Drugs
... on your medication with Cilazapril Coupon from RX24 Drugs. Print a free savings card , present it to your pharmacy , check ... What is Cilazapril. Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It ... Cilazapril mechanism of action. Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the ... Indication of Cilazapril. Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. ...
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Heparin and cilazapril together inhibit injury-induced intimai hyperplasia<...Heparin and cilazapril together inhibit injury-induced intimai hyperplasia<...
Heparin and cilazapril together inhibit injury-induced intimai hyperplasia. Alexander W. Clowes, Monika M. Clowes, Selina C. ... Heparin and cilazapril together inhibit injury-induced intimai hyperplasia. / Clowes, Alexander W.; Clowes, Monika M.; Vergel, ... Clowes, AW, Clowes, MM, Vergel, SC, Müller, RKM, Powell, JS, Hefti, F & Baumgartner, HR 1991, Heparin and cilazapril together ... title = "Heparin and cilazapril together inhibit injury-induced intimai hyperplasia",. abstract = "Both heparin and the ...
https://ucdavis.pure.elsevier.com/en/publications/heparin-and-cilazapril-together-inhibit-injury-induced-intimai-hy
Cilazaprilate, Cilazapril RSS Impurity, Drug Metabolites, Labeled Isotopes, Process Impurities, DegrCilazaprilate, Cilazapril RSS Impurity, Drug Metabolites, Labeled Isotopes, Process Impurities, Degr
All Impurities,Metabolites & Labelled Isotopes are supplied with COA, Mass & H1NMR data, additional data would be provided at request with Nominal cost.. All Impurities,Metabolites & Labelled Isotopes listed are compound synthesized for pharmaceutical research ...
http://www.alfaomegapharma.com/Cilazapril-Impurity.php
Buy Inhibace :: Prices, Side Effects, Precaution :: Detailed Drug InformationBuy Inhibace :: Prices, Side Effects, Precaution :: Detailed Drug Information
Inhibace (Generic name: Cilazapril) is used to treat high blood pressure (hypertension) and congestive heart failure (CHF). ... Do not take Inhibace if you are allergic to Cilazapril or any of other ingredients in this medication. Before taking Inhibace, ... Brand Inhibace is manufactured by Hoffman - La Roche from Canada and the generic Cilazapril comes from Canada. Inhibace comes ... Cilazapril belongs to the class of medications known as converting enzyme (ACE) inhibitors; it controls blood pressure and ...
https://www.bigmountaindrugs.com/Drug/Inhibace
Category:Carboxylic acids - Wikimedia CommonsCategory:Carboxylic acids - Wikimedia Commons
ácido carboxílico (es); Карбон қышқылдары (kk-kz); Asid karboksilik (ms); كاربون قىشقىلدارى (kk-cn); Карбоксилна киселина (bg); کاربوکسلک تیزاب (pnb); 羧酸 (zh-hk); Karboxylová kyselina (sk); карбонові кислоти (uk); 羧酸 (zh-hant); 羧酸 (zh-cn); 카복실산 (ko); Carboxylsýra (fo); karboksilata acido (eo); Карбоксилна киселина (mk); Karboksilne kiseline (bs); কার্বক্সিলিক অ্যাসিড (bn); acide carboxylique (fr); Karboksilne kiseline (hr); axit cacboxylic (vi); كاربون قىشقىلدارى (kk-arab); Karbon qışqıldarı (kk-latn); Karboksielsuur (af); карбоксилна киселина (sr); 羧酸 (zh-sg); Карбон қышқылдары (kk-cyrl); karboksylsyre (nn); karboksylsyre (nb); Asam karboksilat (su); 羧酸 (lzh); ترشی کاربۆکسیلی (ckb); carboxylic acid (en); حمض كربوكسيلي (ar); 羧酸 (yue); ...
https://commons.wikimedia.org/wiki/Category:Carboxylic_acids?uselang=de
Alti-Piroxicam Advanced Patient Information - Drugs.comAlti-Piroxicam Advanced Patient Information - Drugs.com
Detailed drug Information for Alti-Piroxicam. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
https://www.drugs.com/cons/alti-piroxicam.html
Diclofenac And Misoprostol (Oral Route) Proper Use - Mayo ClinicDiclofenac And Misoprostol (Oral Route) Proper Use - Mayo Clinic
Using this medicine while you are pregnant can cause very serious birth defects. Use two forms of effective birth control to keep from getting pregnant while you are using this medicine and after treatment ends. The most effective forms of birth control are hormone birth control pills, patches, shots, vaginal rings, or implants, an IUD, or a vasectomy (for men). One of these forms of birth control should be combined with a condom, a diaphragm, or a cervical cap. Also, you must have a negative pregnancy test within 2 weeks before you will be allowed to take this medicine. If you think you have become pregnant while using this medicine, stop taking this medicine and tell your doctor right away. This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. This medicine may cause bleeding in your stomach or intestines. These problems can happen without ...
https://www.mayoclinic.org/drugs-supplements/diclofenac-and-misoprostol-oral-route/proper-use/drg-20061810?p=1
Bumetanide (Oral Route) Before Using - Mayo ClinicBumetanide (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
https://www.mayoclinic.org/drugs-supplements/bumetanide-oral-route/before-using/drg-20071274?p=1
ACEi/ARB Alone Versus ACEi/ARB Plus Steroids in the Treatment of Primary IgA Nephropathy, a RCT - Full Text View -...ACEi/ARB Alone Versus ACEi/ARB Plus Steroids in the Treatment of Primary IgA Nephropathy, a RCT - Full Text View -...
Cilazapril. Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. ...
https://clinicaltrials.gov/ct2/show/NCT00378443
MARC Minutes 125th MeetingMARC Minutes 125th Meeting
4.1.8.6 Venlafaxine / cilazapril and urinary retention, aggravated renal failure (69409). Discussion. See minute item 4.1.1.6 ... 4.1.1.6 Venlafaxine / cilazapril and pancreatitis, abdominal pain, vomiting, fever [death] (69410). Discussion. Also see minute ... NZPhvC informed the Committee that in the CARM database there were six reports of pancreatitis with cilazapril from a total of ... In the WHO data base the IC values were negative for pancreatitis with both cilazapril and venlafaxine. The product data sheet ...
http://www.medsafe.govt.nz/profs/adverse/Minutes125.htm
HydrochlorothiazideCaptoprilEnalaprilEffect of cilazaprilAngiotensinPharmacokinetics and pharmacodynamics of cilazaprilBenazeprilInhibitorAntihypertensiveDesign of cilazaprilAllergic to cilazaprilTherapy with cilazaprilMonohydrateHypertensionInhibitorsCilazaprilatHCTZCoronaryDrugsLeft ventricularAmlodipineCongestive1.25PatientsCardiacDosesDoseHypertrophyRocheInhibitionEjectionSignificantlyMedicationsRatsCardiovascularEffectsCarotidBlood pressureKidney
Hydrochlorothiazide14
  • To treat high blood pressure, cilazapril may be used alone or in combination with diuretics (water pills) known as thiazide diuretics (e.g., hydrochlorothiazide) when one medication has not been found to sufficiently control blood pressure. (medbroadcast.com)
  • This combination product contains two active medications: cilazapril and hydrochlorothiazide. (medbroadcast.com)
  • Each pink, film-coated oval tablet, debossed and scored with '5' to the left side of the score and '12.5' to the right side of the score, 'N' on the other side of the tablet contains cilazapril 5 mg and hydrochlorothiazide 12.5 mg. (medbroadcast.com)
  • This combination medication is used to make dosing more convenient for people who are already taking both of these medications, cilazapril and hydrochlorothiazide, separately. (medbroadcast.com)
  • Patients who do not respond adequately to cilazapril monotherapy usually respond with the addition of a diuretic such as hydrochlorothiazide. (springer.com)
  • Preliminary data suggest that cilazapril is of comparable antihypertensive efficacy to usual therapeutic dosages of hydrochlorothiazide, slow release propranolol, nitrendipine, captopril and enalapril. (springer.com)
  • A total of 49 patients randomly received either cilazapril alone or cilazapril in combination with hydrochlorothiazide (a diuretic ) and amlodipine (a calcium channel blocker ) for 24 weeks. (alportsyndromenews.com)
  • This informal interaction caused to change hydrochlorothiazide and cilazapril crystalline structure to amorphous form resulting sensation in the increased in collection the dissolution of the drug. (thecollectibleornamentshoppe.com)
  • Inhibace comes in several different strengths: 1 mg, 2.5 mg, 5 mg, and 5 mg/12.5 mg (cilazapril/hydrochlorothiazide). (bigmountaindrugs.com)
  • Objective of current study was to prepare various cilazapril and hydrochlorothiazide mixtures, to create a matrix effect in the drug and to determine the determination of these active substances in drug samples after optimum conditions. (ujpr.org)
  • In the spectrophotometric method, 100 mgL −1 solutions were prepared in cilazapril, hydrochlorothiazide in methanol + 0.1 m HCL solvent and then mixtures of these solutions were prepared between specific ppm. (ujpr.org)
  • It was observed that the main component analysis applied as a result of spectrophotometric determination of various mixtures of cilazapril and hydrochlorothiazide used in the study gave correct results. (ujpr.org)
  • Each pale red, oval-shaped, single-scored, film-coated tablet, engraved 'CIL+' on the top half and '5+12.5' on the bottom half, contains 5 mg of cilazapril and 12.5 mg of hydrochlorothiazide. (canada.com)
  • Each pale red, oval-shaped, single-scored, film-coated tablet, engraved 'CIL+' on the one half and '5+12.5' on other, contains 5 mg of cilazapril and 12.5 mg of hydrochlorothiazide. (pharmasave.com)
Captopril1
  • In vitro , cilazapril was a highly specific and more potent inhibitor of ACE than enalapril and captopril. (springer.com)
Enalapril2
  • Similarly in animal studies, compared to equal doses of enalapril, cilazapril 0.25mg produced more pronounced inhibition of ACE (96% vs 76%) and had a longer duration of action. (springer.com)
  • The rate of recovery of ACE activity was slower after administration of cilazapril (5 to 6%/h) than after enalapril (10%/h). (springer.com)
Effect of cilazapril3
  • METHODS AND RESULTS We conducted a randomized, double-blind placebo-controlled trial to assess the effect of cilazapril in angiographic restenosis prevention after percutaneous transluminal coronary angioplasty (PTCA). (ahajournals.org)
  • A clinical trial, results of which were published in the Archives of Endocrinology and Metabolism in 2008 , looked at the effect of cilazapril in women with diabetes and early signs of kidney problems. (alportsyndromenews.com)
  • There was no evidence of a dose-related antihypertensive effect of cilazapril at steady state and, with the small numbers of subjects used in this study, there was no evidence of 24-h BP control with monotherapy. (austin.org.au)
Angiotensin22
  • Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. (wikipedia.org)
  • Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. (springer.com)
  • Cilazapril is a prodrug which is hydrolysed to the active angiotensin converting enzyme (ACE) inhibitor cilazaprilat after absorption. (springer.com)
  • Cilazapril causes an increase in plasma renin activity and a decrease in plasma angiotensin II and aldosterone concentrations. (springer.com)
  • Most data support the hypothesis that the beneficial haemodynamic effects of cilazapril result from ACE inhibition and the consequent reduction of angiotensin II levels, which either directly or indirectly causes dilatation of peripheral vessels and reduction of vascular resistance. (springer.com)
  • Additionally, cilazapril effectively antagonised the pressor response to angiotensin I infusions, showing high potency in Schild-plot analysis (apparent K i dose of 0.6mg), and abolished the induced venoconstriction and attenuated the angiotensin I-dependent increase of splanchnic vascular resistance in normal volunteers. (springer.com)
  • Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? (ahajournals.org)
  • BACKGROUND Cilazapril is a novel angiotensin converting enzyme inhibitor with antiproliferative effects in the rat model after balloon injury. (ahajournals.org)
  • CONCLUSIONS Long-term angiotensin converting enzyme inhibition with cilazapril in a dose of 5 mg b.i.d. does not prevent restenosis and does not favorably influence the overall clinical outcome after PTCA. (ahajournals.org)
  • To compare the effects of an angiotensin-converting enzyme (ACE) inhibitor (cilazapril), a β-blocker (atenolol), and a calcium channel blocker (nifedipine retard) on the quality of life of patients with mild-to-moderate hypertension. (acpjc.org)
  • Cilazapril (CPL) ( Figure 1 (b)) belongs to angiotensin converting enzyme (ACE) inhibitor. (scirp.org)
  • Cilazapril blocks the activity of an enzyme called angiotensin-converting-enzyme (ACE). (alportsyndromenews.com)
  • Cilazapril is a long-acting angiotensin-converting enzyme inhibitor that has been effective in producing vascular remodelling in hypertensive vascular disease. (scienceopen.com)
  • Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment. (scienceopen.com)
  • Both heparin and the angiotensin converting enzyme inhibitor cilazapril inhibit intimai thickening in rat carotid arteries injured by the passage of a balloon catheter. (elsevier.com)
  • Cilazapril administration in the dose range of 1.25-2.5 mg produced a dose-proportional inhibition of angiotensin-converting enzyme (ACE) activity that was maximum 2 h after drug administration. (austin.org.au)
  • While cilazapril may be prescribed by endorsement to existing patients, this should be used as an opportunity to proactively switch patients to another ACE inhibitor, angiotensin II receptor blocker (ARB) or another medicine. (bpac.org.nz)
  • In New Zealand, approximately 60% of people taking angiotensin-converting enzyme (ACE) inhibitors are still being prescribed cilazapril. (bpac.org.nz)
  • Prescribers will need to endorse any new prescriptions for cilazapril for patients who were taking this medicine prior to 1 May, 2021, but ultimately all patients will need to switch to a different ACE inhibitor, angiotensin II receptor blocker (ARB) or another medicine. (bpac.org.nz)
  • Approximately half a million people in New Zealand are prescribed an angiotensin-converting enzyme (ACE) inhibitor, and of these, approximately 60% are still being prescribed cilazapril, despite recommendations in 2018 to consider switching due to potential supply issues. (bpac.org.nz)
  • Furthermore, bosentan had an additive effect to the angiotensin-converting enzyme inhibitor cilazapril. (ahajournals.org)
  • OLETF rats were orally given cilazapril (an angiotensin-converting enzyme inhibitor, 1 or 10 mg/kg), E4177 (an angiotensin AT 1 receptor antagonist, 10 mg/kg), or vehicle for 26 or 40 weeks (from the age of 20 to 46 or 60 weeks). (ahajournals.org)
Pharmacokinetics and pharmacodynamics of cilazapril3
  • A comparison of the pharmacokinetics and pharmacodynamics of cilazapril between Chinese and Caucasian healthy, normotensive volunteers. (scienceopen.com)
  • Austin Health Research Online: Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. (austin.org.au)
  • Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. (austin.org.au)
Benazepril1
  • On the basis of type, the Global Prils Market is segmented into benazepril, cilazapril, quinapril, and ramipril. (medgadget.com)
Inhibitor4
  • Cilazapril is an ACE-inhibitor used to treat high blood pressure. (alportsyndromenews.com)
  • Cilazapril is a pyridazine ACE inhibitor. (rx24drugs.com)
  • Moreover, when the renin inhibitor was administered after injection of renin antibodies (rabbit antiserum, 0.4 ml intravenously) or after cilazapril (10 mg/kg orally), it induced a supplementary fall in blood pressure. (biomedsearch.com)
  • Prescribers in New Zealand are highly reliant on cilazapril as their "go-to" ACE inhibitor, but this prescribing is out of step with many other countries where cilazapril is infrequently used, such as Australia and the United Kingdom. (bpac.org.nz)
Antihypertensive3
  • Quality of life with three antihypertensive treatments: cilazapril, atenolol, nifedipine. (acpjc.org)
  • Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. (scirp.org)
  • Telmisartan, Cilazapril and Terazosin HCL, which belong to different groups of antihypertensive drugs, were chosen for study. (scirp.org)
Design of cilazapril2
Allergic to cilazapril1
  • Do not take Inhibace if you are allergic to Cilazapril or any of other ingredients in this medication. (bigmountaindrugs.com)
Therapy with cilazapril2
  • During therapy with cilazapril, neither heart rate nor left and right ventricular ejection fraction significantly changed and baroreceptor activity was also unaffected. (springer.com)
  • We undertook a study to determine whether therapy with cilazapril would modify the expression of PKD in the Han:SPRD-cy rat, a model of autosomal dominant PKD that closely resembles human disease. (scienceopen.com)
Monohydrate2
  • Each yellow, oval-shaped, biconvex tablet, scored on one side and imprinted with the 'P' logo and '1' on the other side, contains anhydrous cilazapril 1 mg as cilazapril monohydrate. (medbroadcast.com)
  • N' on one side and '1' on the other side, contains anhydrous cilazapril 1 mg as cilazapril monohydrate. (pharmasave.com)
Hypertension9
  • Given once daily at doses between 2.5 and 5mg, cilazapril reduces arterial blood pressure in patients with mild to moderate essential and renal hypertension. (springer.com)
  • Cilazapril should provide an effective alternative in the treatment of hypertension and, if preliminary data are confirmed, in congestive heart failure. (springer.com)
  • Oral administration of cilazapril 2.5 to 5mg to patients with renal disease, or of 10mg plus hydrochlorbthiazide to patients with severe hypertension, reduced renal vascular resistance without affecting renal plasma flow, glomerular filtration rate or renal blood flow. (springer.com)
  • Acute effects of cilazapril on coronary hemodynamics in patients with renovascular hypertension. (semanticscholar.org)
  • Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. (scienceopen.com)
  • Cilazapril is an effective treatment for hypertension in this model of progressive renal disease and may have benefits beyond the prevention of cardiovascular morbidity. (scienceopen.com)
  • Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure . (rx24drugs.com)
  • Inhibace (Generic name: Cilazapril) is used to treat high blood pressure (hypertension) and congestive heart failure (CHF). (bigmountaindrugs.com)
  • Twenty-two patients with essential hypertension received a single dose of 2.5 mg cilazapril and were then randomised into a double-blind parallel group study to receive either placebo, 1.25 mg cilazapril + 0.5 mg cyclopenthiazide (CPTZ), 2.5 mg cilazapril + 0.5 mg CPTZ, or 2.5 mg cilazapril alone for 1 month. (austin.org.au)
Inhibitors4
  • Cilazapril has been well tolerated and exhibits tolerability typical of ACE inhibitors as a class, including their lack of detrimental effect on glucose or lipid metabolism. (springer.com)
  • Although no clinical trials assessing cilazapril specifically in Alport syndrome patients have been conducted, it is among the ACE-inhibitors recommended as first-line treatments for the disease. (alportsyndromenews.com)
  • Cilazapril is generally well-tolerated and has similar side effects to other ACE-inhibitors. (alportsyndromenews.com)
  • 1, 2 Although a range of ACE inhibitors are funded, familiarity means cilazapril remains a favoured choice by many clinicians. (bpac.org.nz)
Cilazaprilat1
  • After oral administration of a single dose of 2.5 mg cilazapril, the active diacid cilazaprilat appeared rapidly in the plasma (Tmax 2.0 +/- 0.2 h). (austin.org.au)
HCTZ1
  • The groups did not differ in mean change from baseline in DBP (cilazapril -14.7, atenolol -15.5, nifedipine -14.7 mm Hg), but more patients in the cilazapril group (36%) than in the atenolol group (25%) or the nifedipine group (24%) required HCTZ ( P = 0.01). (acpjc.org)
Coronary4
  • Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group. (ahajournals.org)
  • The mean difference in minimal coronary lumen diameter between post-PTCA and follow-up angiogram (primary end point) was -0.29 +/- 0.49 mm in the control group and -0.27 +/- 0.51 mm in the cilazapril group. (ahajournals.org)
  • The aim of this study was to investigate the efficacy of an ACEI, Cilazapril, on left ventricular remodeling in patients with ischemic LVF, who underwent coronary interventions. (koreamed.org)
  • CONCLUSION: Cilazapril is a beneficial adjunctive therapeutic agent in patients with ischemic left ventricular failure for the prevention of ventricular dilatation, especially after coronary intervention. (koreamed.org)
Drugs1
  • At the lower doses, the inhibitory effects of heparin and cilazapril were additive when the drugs were used together. (elsevier.com)
Left ventricular1
  • However, cilazapril has been shown to improve left ventricular diastolic function in patients with left ventricular hypertrophy after single doses and during long term administration. (springer.com)
Amlodipine1
  • Effect of amlodipine and cilazapril treatment on platelet Ca2+ handling in spontaneously hypertensive rats. (nii.ac.jp)
Congestive3
  • Cilazapril controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and making the heart pump more efficiently. (medbroadcast.com)
  • In small studies cilazapril has produced sustained beneficial haemodynamic effects in patients with congestive heart failure. (springer.com)
  • In patients with congestive heart failure, a single dose of cilazapril 0.5 to 2.5mg caused a decrease in arterial blood pressure, pulmonary wedge pressure and systemic vascular resistance, and an increase in cardiac output. (springer.com)
1.251
  • In humans, the maximum degree of ACE inhibition exceeded 90%, even after low doses of cilazapril (1.25mg) and was apparent about 2 to 3 hours after administration. (springer.com)
Patients6
  • Patients received cilazapril 2.5 mg in the evening after successful PTCA and 5 mg b.i.d. for 6 months or matched placebo. (ahajournals.org)
  • For the per-protocol analysis, quantitative angiography after PTCA and at follow-up was available in 595 patients who complied with the treatment regimen (309 control, 286 cilazapril). (ahajournals.org)
  • Side effects were the most common reason for withdrawal with nifedipine recipeints having a greater withdrawal rate than atenolol or cilazapril recipients (17%, 8%, and 5% of patients, respectively, P = 0.001). (acpjc.org)
  • Neutropenia (or loss of neutrophils, a type of immune cell) has been reported in some patients taking cilazapril. (alportsyndromenews.com)
  • cilazapril hydrochloride capsules and alprazolam tablets should be partly used cautiously used in patients receiving concomitant therapy training with other antihypertensives. (thecollectibleornamentshoppe.com)
  • From 1 May, 2021, cilazapril will no longer be funded for new patients. (bpac.org.nz)
Cardiac1
  • Cilazapril prevents cardiac hypertrophy and postischemic myocardial dysfunction in hyperthyroid rats'Thyroid. (nii.ac.jp)
Doses1
  • In animal models single doses of cilazapril elicited a significant reduction of blood pressure which lasted about 6 hours. (springer.com)
Dose1
  • Heparin (0.1-0.3 mg/kg/hr) administered by continuous intravenous infusion with or without cilazapril (0-25 mg/kg/day p.o.) produced a dose-dependent inhibition of smooth muscle accumulation at 14 days after rat carotid ballooning. (elsevier.com)
Hypertrophy1
  • Glomerulosclerosis and glomerular hypertrophy in OLETF rats were improved by cilazapril and E4177 to a comparable extent. (ahajournals.org)
Roche1
  • Brand Inhibace is manufactured by Hoffman - La Roche from Canada and the generic Cilazapril comes from Canada. (bigmountaindrugs.com)
Inhibition1
  • A 7-day course of heparin combined with cilazapril, a regimen that might be applicable in the clinical setting, produced an 80% inhibition of intimai thickening at 28 days. (elsevier.com)
Ejection1
  • Ejection fraction (EF) was increased from 44.4+/-3.2 to 52.4+/-2.8% after 12 weeks of Cilazapril p=0.034. (koreamed.org)
Significantly1
  • Cilazapril or E4177 did not significantly affect body weight or plasma glucose and insulin levels of OLETF rats, indicating the minor effects on diabetes itself. (ahajournals.org)
Medications1
  • Cilazapril is used in addition to digoxin, thiazide diuretics, or both for the treatment of CHF when these medications have not produced enough of a response. (medbroadcast.com)
Rats1
  • Twenty-week-old OLETF rats were divided into four groups: (1) a vehicle (saline)−treated group (control), (2) a cilazapril (1 mg/kg per day)−treated group, (3) a cilazapril (10 mg/kg per day)−treated group, and (4) an E4177 (10 mg/kg per day)−treated group. (ahajournals.org)
Cardiovascular1
  • New Zealand's reliance on the cardiovascular medicines metoprolol succinate and cilazapril is out of step with other countries, writes Dr Richard Medlicott, [Previous] Medical Director of the Royal New Zealand College of General Practitioners. (pharmac.govt.nz)
Effects1
  • Side effects of Cilazapril were 3 dry cough (3/25, 12%) and 1 facial edema, 1 hypotension and 1 dizziness. (koreamed.org)
Carotid1
  • In a rat model with carotid artery injury caused by endothelial removal, administration of cilazapril before and after injury prevented the myointimal proliferation that occurred in untreated controls. (springer.com)
Blood pressure4
  • RESULTS: Blood pressure and heart rate were not changed after Cilazapril. (koreamed.org)
  • Cilazapril, atenolol, and nifedipine were equally effective in controlling blood pressure but nifedipine was associated with more frequent adverse-effect-related drug discontinuation than was atenolol or cilazapril. (acpjc.org)
  • By inhibiting the activity of ACE, cilazapril works through several mechanisms to lower blood pressure. (alportsyndromenews.com)
  • Cilazapril decreased blood pressure and Ro 42-5892 was more effective than cilazapril. (biomedsearch.com)
Kidney1
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