Cilastatin: A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Dipeptidases: EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13.CyclopropanesAnti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Sulbactam: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.Protease Inhibitors: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Bacterial Infections: Infections by bacteria, general or unspecified.Genitalia, Female: The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.Library Services: Services offered to the library user. They include reference and circulation.Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.LebanonLevofloxacin: The L-isomer of Ofloxacin.Pneumonia: Infection of the lung often accompanied by inflammation.Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Cross Infection: Any infection which a patient contracts in a health-care institution.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Prescriptions: Directions written for the obtaining and use of PHARMACEUTICAL PREPARATIONS; MEDICAL DEVICES; corrective LENSES; and a variety of other medical remedies.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Medical Assistance: Financing of medical care provided to public assistance recipients.Intraabdominal Infections: Infection within the PERITONEAL CAVITY. A frequent cause is an ANASTOMOTIC LEAK following surgery.Abdominal Cavity: The region in the abdomen extending from the thoracic DIAPHRAGM to the plane of the superior pelvic aperture (pelvic inlet). The abdominal cavity contains the PERITONEUM and abdominal VISCERA, as well as the extraperitoneal space which includes the RETROPERITONEAL SPACE.Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.Abdomen: That portion of the body that lies between the THORAX and the PELVIS.Skin Diseases, Bacterial: Skin diseases caused by bacteria.Enterobacter: Gram-negative gas-producing rods found in feces of humans and other animals, sewage, soil, water, and dairy products.Enterobacter cloacae: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.OsteomyelitisEnterobacter aerogenes: Gram-negative, capsulated, gas-producing rods found widely in nature. Both motile and non-motile strains exist. The species is closely related to KLEBSIELLA PNEUMONIAE and is frequently associated with nosocomial infectionsArthritis, Infectious: Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.Pleural Effusion: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.Pleural DiseasesPleural Effusion, Malignant: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.Pleura: The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.Tuberculosis, Pleural: Tuberculosis of the serous membrane lining the thoracic cavity and surrounding the lungs.Pericardial Effusion: Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.Choroid Plexus: A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
"Cilastatin/imipenem/relebactam - AdisInsight". Springer International Publishing AG. Retrieved 29 April 2016. Livermore, David ...
Edwards SJ, Emmas CE, Campbell HE (2005). "Systematic review comparing meropenem with imipenem plus cilastatin in the treatment ... Discovery and development of imipenem/cilastatin". American Journal of Medicine. 78 (6A): 3-21. doi:10.1016/0002-9343(85)90097- ... and thus is co-formulated with the dehydropeptidase inhibitor cilastatin. Imipenem is available in both intravenous and ... whereas imipenem is usually administered as a 20-minute to one hour infusion. Meropenem is somewhat less potent than imipenem ...
Clinical and pharmacokinetic study of imipenem/cilastatin in children and newborn infants]". Pathologie-biologie. 37 (5): 485- ...
Imipenem/cilastatin may be an alternative *^ For treatment of chronic pulmonary aspergillosis, histoplasmosis, sporotrichosis, ... Imipenem/cilastatin is an alternative, except for acute bacterial meningitis, where meropenem is preferred ...
Unlike imipenem, it is stable to dehydropeptidase-1, so can be given without cilastatin. In 2016 a synthetic peptide-conjugated ... The overall spectrum is similar to that of imipenem, although meropenem is more active against Enterobacteriaceae and less ... Meropenem has a reduced potential for seizures in comparison with imipenem. Several cases of severe hypokalemia have been ...
The imipenem/cilastatin, clindamycin or combinations containing an inhibitor of beta-lactamases (i.e. Augmentin, Unasyn) are ... but remain susceptible to imipenem, cefoxitin, and amoxicillin combined with clavulanic acid (Jolivet-Gougeon et al., 2004). ...
Wood GC, Hanes SD, Croce MA, Fabian TC, Bougher BA (2002). "Comparison of ampicillin-sulbactam and imipenem-cilastatin for the ... Among one set of isolates from Walter Reed Army Medical Center, 13 (35%) were susceptible to imipenem only, and two (4%) were ...
To prevent its rapid degradation, imipenem is normally coadministered with cilastatin, an inhibitor of this enzyme. Nicolaou, K ... One such derivative - imipenem - was formulated in 1985. Imipenem, an N-formimidoyl derivative of thienamycin, is rapidly ...
These include meropenem, imipenem-cilastatin, doripenem, piperacillin-tazobactam, or ceftazidime or cefepime in combination ... imipenem-cilastatin, doripenem, piperacillin-tazobactam, ciprofloxacin or levofloxacin in combination with metronidazole, or ... Antimicrobial regimens for children include an aminoglycoside-based regimen, a carbapenem (imipenem, meropenem, or ertapenem), ... imipenem, meropenem, doripenem, ertapenem). An antimicrobial effective against Gram-negative enteric bacilli (i.e. ...
July 2013). "Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of ...
Amikacin Amphotericin B Ceftobiprole Ceftaroline Carbapenems (such as imipenem/cilastatin) - used as drug of last resort for a ...
Discovery and development of imipenem/cilastatin". The American Journal of Medicine 78 (6A): 3-21. ISSN 0002-9343. PMID 3859213 ... imipenem (pogosto se uporablja v kombinaciji s cilastatinom - imipenem se lahko v ledvicah hidrolizira v nefrotoksičen ...
The imipenem/cilastatin, clindamycin, or combinations containing an inhibitor of beta-lactamases (i.e. Augmentin, Unasyn) are ... can be resistant to third-generation cephalosporins, but remain susceptible to imipenem, cefoxitin, and amoxicillin combined ...
... meropenem and imipenem/cilastatin), or piperacillin/tazobactam for high-risk patients and amoxicillin-clavulanic acid and ... imipenem or meropenem). A subsequent meta-analysis published in 2006 found cefepime to be associated with more negative ...
Piperacillin/tazobactam Procaine benzylpenicillin Ceftazidimeα Meropenemα Aztreonamα Imipenem/cilastatinα Amikacin Azithromycin ...
Procaine benzylpenicillin Cefotaximeα Ceftazidimeα Imipenem/cilastatinα Azithromycin Chloramphenicol Ciprofloxacin Doxycycline ...
... much like the imipenem/cilastatin combination) "Comparative antibacterial activity of carbapenems against P. aeruginosa (1)". ...
J01DF02 Carumonam J01DH02 Meropenem J01DH03 Ertapenem J01DH04 Doripenem J01DH05 Biapenem J01DH51 Imipenem and cilastatin ...
... imipenem/cilastatin, the first carbapenem 1985 - ofloxacin 1986 - mupirocin 1986 - aztreonam 1986 - cefoperazone/sulbactam 1986 ...
Buckley, MM; Brogden, RN; Barradell, LB; Goa, KL (1992). "Imipenem/cilastatin. A reappraisal of its antibacterial activity, ... Clissold, SP; Todd, PA; Campoli-Richards, DM (1987). "Imipenem/cilastatin. A review of its antibacterial activity, ... Not many species are resistant to imipenem except Pseudomonas aeruginosa (Oman) and Stenotrophomonas maltophilia. Imipenem is ... "Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy". Drugs. 33 (3 ...
Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic ... Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its ... Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ... Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the ...
... was approved for use in the United States in 1985. Imipenem/cilastatin is indicated for the treatment of ... Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem. Imipenem/cilastatin was first ... cilastatin prevents renal metabolism of imipenem. Intramuscular injection: imipenem: 60-75% cilastatin: 95-100% The drug is ... Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by ...
Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). *Ceftazidime/avibactam. *Piperacillin/ ...
Imipenem/cilastatin#. *Imipenem/cilastatin/relebactam. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). * ...
Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). *Ceftazidime/avibactam. *Piperacillin/ ...
Imipenem/cilastatin#. *Ampicillin/flucloxacillin. *Ampicillin/sulbactam (Sultamicillin). *Ceftazidime/avibactam. *Piperacillin/ ...
Imipenem/cilastatin/relebactam. References[edit]. *^ a b c d e f g h "Imipenem and Cilastatin". The American Society of Health- ... Imipenem/cilastatin was approved for use in the United States in 1985. Imipenem/cilastatin is indicated for the treatment of ... Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by ... "Imipenem + Cilastatin". International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). ...
Only one patient developed a seizure while on imipenem/cilastatin. Conclusion: The prescription of imipenem/cilastatin at our ... who were not started on imipenem/cilastatin empirically inappropriately received imipenem/cilastatin post-culture results. ... The patients received imipenem/cilastatin mainly for urinary tract infections (27%) or for sepsis of an unknown focus (22%). ... The objective of this study was to evaluate the appropriate use of imipenem/cilastatin in a local tertiary care hospital. The ...
Imipenem. Cilastatin. Anti-Infective Agents, Urinary. Anti-Infective Agents. Renal Agents. Anti-Bacterial Agents. Topoisomerase ... The purpose of this study is to compare the safety and effectiveness of levofloxacin with imipenem/cilastatin in the treatment ... Levofloxacin compared with imipenem/cilastatin followed by ciprofloxacin in adult patients with nosocomial pneumonia: a ... A Multicenter, Randomized, Open Label Study to Compare the Safety and Efficacy of Levofloxacin With That of Imipenem/Cilastatin ...
Imipenem Cilastatin Injection manufacturers, Traders, and Imipenem Cilastatin Injection, Imipenem Cilastatin Injection ... Find the list of best Imipenem Cilastatin Injection suppliers & Manufacturers. Yellow Pages Directory of Imipenem Cilastatin ... Deals in imipenem cilastatin injection, Labetalol 4 ml Injection, Teicoplanin 400 mg ...
Imipenem and Cilastatin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using imipenem and cilastatin injection,. *tell your doctor and pharmacist if you are allergic to imipenem or cilastatin ... Use imipenem and cilastatin injection until you finish the prescription, even if you feel better. If you stop using imipenem ... Use imipenem and cilastatin injection exactly as directed. Do not use more or less of it or use it more often than prescribed ...
Cilastatin, and Relebactam Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... It works by preventing bacteria from destroying imipenem.. Antibiotics such as imipenem, cilastatin, and relebactam injection ... cilastatin, and relebactam injection,. *tell your doctor and pharmacist if you are allergic to imipenem, cilastatin, relebactam ... Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of ...
Imipenem dosage information for adults and children. Includes dosages for Bacterial Infection, Urinary Tract Infection, ... Doses represent the quantity of imipenem; an equal amount of cilastatin is also present.. -Adult dose should be based on ... Cilastatin / Imipenem Dosage. Medically reviewed by Drugs.com. Last updated on Jan 14, 2019. ... CrCl 60 to less than 90 mL/min: 750 mg (imipenem component) IV every 8 hours. -CrCl 30 to less than 60 mL/min: 500 mg (imipenem ...
... imipenem and Duration. These medicines may also interact with certain foods or diseases. ... Cilastatin / imipenem is in the drug class carbapenems.. *Cilastatin / imipenem is used to treat the following conditions: * ... cilastatin / imipenem. A total of 75 drugs are known to interact with cilastatin / imipenem. ... There were no interactions found in our database between cilastatin / imipenem and Duration - however, this does not ...
Read the side effects of Imipenem and Cilastatin as described in the medical literature. In case of any doubt consult your ... Imipenem and Cilastatin - Information. Imipenem and Cilastatin is a broad spectrum beta-lactam antibiotic, prescribed for ... Side effect(s) of Imipenem and Cilastatin Read the side effects of Imipenem and Cilastatin as described in the medical ...
Imipenem and Cilastatin for Injection; Imipenem and Cilastatin for Injection, USP; Primaxin; RAN-Imipenem-Cilastatin ... Imipenem and Cilastatin - Last updated on July 5, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ...
Cilastatin 500mg solution infusion vials. FREE delivery options available. Trusted service, convenient and safe shopping online ... Imipenem 500mg / Cilastatin 500mg solution infusion vials. Registered UK Online Pharmacy - Prescription item. To purchase this ...
Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. Imipenem and ... cilastatin is a combination medicine used to treat severe infections of the lower respiratory tract, skin, stomach, or female ... Imipenem is an antibiotic that fights bacteria.. Cilastatin helps imipenem work more effectively by preventing the breakdown of ... What are the possible side effects of imipenem and cilastatin?. Get emergency medical help if you have signs of an allergic ...
Imipenem information about active ingredients, pharmaceutical forms and doses by Jodas Expoim, Cilastatin; Imipenem indications ... Available forms, composition and doses of Cilastatin; Imipenem:. *Injectable; Injection; Cilastatin Sodium 500 mg; Imipenem 500 ... Find online pharmacy, drugstore, pharma or beauty shop where to order or buy Cilastatin; Imipenem brand or generic online:. ... J01DH51 - Imipenem and enzyme Inhibitor. Pharmaceutical companies: manufacturers, researchers, developers, local distributors ...
Imipenem/Cilastatin Kabi Bejelentkezés szükséges. Imipenem/Cilastatin Kabi. Felhívjuk figyelmét, hogy a magyar jogszabályi ...
J01DH51 - Imipenem and enzyme Inhibitor. Pharmaceutical companies: manufacturers, researchers, developers, local distributors ...
To study the effect of moxifloxacin versus imipenem/cilastatin (hereafter referred to as imipenem) treatment on the mortality ... Effect of moxifloxacin versus imipenem/cilastatin treatment on the mortality of mice infected intravenously with different ... The data show that moxifloxacin was as efficacious as imipenem in reducing the mortality rate of mice suffering from a severe ... Groups of 20 mice each were infected intravenously with different strains of B. fragilis [moxifloxacin and imipenem susceptible ...
Active Comparator: Imipenem/cilastatin Drug: Imipenem/cilastatin 1000 mg intravenously every 8 hours for a period of 7 to 14 ... Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative ... Imipenem. Cilastatin. Anti-Bacterial Agents. Anti-Infective Agents. Protease Inhibitors. Enzyme Inhibitors. Molecular ... A Study of Efficacy/Safety of Intravenous S-649266 Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections (APEKS- ...
Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator- ... Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator- ...
Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator- ... Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator- ... This study will evaluate the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) (MK-7655A) compared to ...
To identify and review studies which have sought to define the pharmacokinetics of imipenem and cilastatin in patients ... Total body clearance of cilastatin ranged between 9 and 32 ml/min. Total body clearance of both imipenem and cilastatin was ... Drussano, GL, Standiford, HC 1985Pharmacokinetic profile of imipenem/cilastatin in normal volunteersAm J Med784753Google ... Acute kidney failure Cilastatin Clearance CRRT Haemodialysis Haemofiltration Imipenem Pharmacokinetics This is a preview of ...
1988) Imipenem/cilastatin in the treatment of severe nosocomial pneumonia. S Afr Med J 74:390-392, . ... 1986) Imipenem/cilastatin for the treatment of respiratory tract infections in patients with ventilatory support. Infection 14: ... 1987) Clinical outcome of nosocomial pneumonia following imipenem/cilastatin therapy. Drug Intell Clin Pharm 21:272-276, . ... 1985) Treatment of pneumonia with imipenem/cilastatin. NZ Med J 98:494-497, . ...
Imipenem; Cilastatin injection. What is imipenem/cilastatin. injection?. IMIPENEM; CILASTATIN (Primaxin®) is an. antibiotic. ... Imipenem-cilastatin is usually given in a hospital.. You may be given imipenem-cilastatin to take home to. complete your ... Cilastatin is. added to make imipenem work better. Imipenem-cilastatin treats many kinds of infections. including those of the ... Imipenem/cilastatin is for injection into a muscle or. infusion into a vein. Imipenem/cilastatin is usually. given in a ...
Imipenem) drug information & product resources from MPR including dosage information, educational materials, & patient ... Imipenem 500mg, cilastatin sodium 500mg; IM inj; sodium content 2.8mEq/g imipenem. ... Base dose on imipenem component. Lower respiratory tract, skin and skin structure, gynecologic: mild to moderate: 500-750mg ...
Dexamethasone/Imipenem/Cilastatin/Polymyxin B/Tobramycin preparation information is provided by Wedgewood Pharmacy. ... Dexamethasone/Imipenem/Cilastatin/Polymyxin B/Tobramycin Otic Suspension may be prescribed for Infection-Bacterial. ... 1 strength combination of Dexamethasone/Imipenem/Cilastatin/Polymyxin B/Tobramycin Otic Suspension is available.*Cilastatin 1 % ... Dexamethasone/Imipenem/Cilastatin/Polymyxin B/Tobramycin Otic Suspension. Prescribed For: Dogs. May be Prescribed For: ...
Imipenem crosses the placenta and is distributed into milk. When given with cilastatin, imipenem is eliminated by both renal ... Bioavailability after IM injection is approximately 95% for imipenem and 75% for cilastatin. Imipenem is distributed widely ... Imipenem:Cilastatin Suspension for IM Injection: 500 mg:500 mg, 750 mg:750 mg; Primaxin® I.M. (Merck); (Rx) ... Cilastatin inhibits the metabolism of imipenem by DHP 1 on the brush borders of renal tubular cells. This serves two functions ...
  • Little information is available on possible cross-sensitivity to liver injury among the different betalactam antibiotics, but patients with clinically apparent liver injury due to imipenem should probably avoid the other carbapenems. (wikipedia.org)
  • In large clinical trials, imipenem was associated with transient and asymptomatic elevations in serum aminotransferase levels in about 6% of patients given the drug for five to 14 days. (wikipedia.org)
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