Chemicals and Drugs
CilastatinImipenemDipeptidasesThienamycinsCyclopropanesDrug CombinationsProtease InhibitorsSulbactam
Cilastatin
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
Imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Dipeptidases
EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13.
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Cyclopropanes
Drug Combinations
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Protease Inhibitors
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Sulbactam
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

Multiple roles for IL-12 in a model of acute septic peritonitis. (1/118)

The present study addressed the role of IL-12 in a murine model of septic peritonitis, induced by cecal ligation and puncture (CLP). Although CLP surgery induced IL-12 production at 6 and 24 h after surgery, IL-12 immunoneutralization was clearly deleterious in this model: 54% of CLP mice receiving preimmune serum survived, whereas mice administered IL-12 antisera prior to CLP experienced a 25% survival rate. IL-12 immunoneutralization not only led to increased mortality, but also appeared to promote a shift away from IL-12 and IFN-gamma, in favor of IL-10. This cytokine shift corresponded to changes in bacterial load, as CLP mice receiving IL-12 antiserum yielded more CFUs from the peritoneal cavity at 24 h after CLP. To address the role of bacterial infection in IL-12 antiserum-induced mortality following CLP, antibiotics were administered for 4 days after surgery. Despite regular antibiotic administration, IL-12 immunoneutralization still reduced survival in CLP mice. Furthermore, histology of the ceca revealed that mice administered IL-12 antisera failed to show typical organization of the damaged cecum wall. Accordingly, Gram staining revealed bacteria within peritoneal fluids from these mice, while peritoneal fluids from CLP mice that received preimmune serum and antibiotics were free of bacteria. Altogether, these data suggested multiple important roles for IL-12 in the evolution of murine septic peritonitis.  (+info)

Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. (2/118)

The effect of antibiotics on the acute lung injury induced by virulent Pseudomonas aeruginosa PA103 was quantitatively analyzed in a rat model. Lung injury was induced by the instillation of PA103 directly into the right lower lobes of the lungs of anesthetized rats. The alveolar epithelial injury, extravascular lung water, and total plasma equivalents were measured as separate, independent parameters of acute lung injury. Four hours after the instillation of PA103, all the parameters were increased linearly depending on the dose of P. aeruginosa. Next, we examined the effects of intravenously administered antibiotics on the parameters of acute lung injury in D-galactosamine-sensitized rats. One hour after the rats received 10(7) CFU of PA103, an intravenous bolus injection of aztreonam (60 mg/kg) or imipenem-cilastatin (30 mg/kg) was administered. Despite an MIC indicating resistance, imipenem-cilastatin improved all the measurements of lung injury; in contrast, aztreonam, which had an MIC indicating sensitivity, did not improve any of the lung injury parameters. The antibiotics did not generate different quantities of plasma endotoxin; therefore, endotoxin did not appear to explain the differences in lung injury. This in vivo model is useful to quantitatively compare the efficacies of parenteral antibiotic administration on Pseudomonas airspace infections.  (+info)

Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. (3/118)

DA-1131, a new carbapenem antibiotic, undergoes renal metabolism by renal dehydropeptidase I (DHP-I), located on the brush border of the proximal tubular cell. Species differences with regard to the effects of cilastatin, a renal DHP-I inhibitor, were investigated after a 1-min intravenous infusion of DA-1131, with or without cilastatin, to rats, rabbits, and dogs. After intravenous infusion, the nonrenal clearance (CL(NR)) of DA-1131 was significantly slower in rats (3.00 versus 8.01 ml/min/kg) and rabbits (2.41 versus 6.77 ml/min/kg) when the drug was coadministered with cilastatin; this could be due to the slower metabolism of DA-1131 by rat and rabbit kidney DHP-I. This indicated that renal metabolism of DA-1131 by renal DHP-I was inhibited by cilastatin. However, coadministration with cilastatin to dogs did not affect the CL(NR) of DA-1131.  (+info)

Modification of acquired immunity in mice by imipenem/cilastatin. (4/118)

The immunomodulating properties of antimicrobial drugs may have important implications for clinical practice, particularly for those patients whose immune system has been compromised. In this study, we assessed the influence of different treatments with a beta-lactam antibiotic (imipenem/cilastatin) on several acquired immune responses of BALB/c mice; splenocyte responses to specific mitogens and to sheep red blood cells, IL-2 production and proportions of the different lympho-monocytic populations. Impenem/cilastatin was shown to modify some lymphocyte-associated immune functions and it would be useful to investigate whether immunomodulatory effects also occur in humans.  (+info)

Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial. (5/118)

An open, randomized, multinational, multicentre study was conducted to compare the efficacy, safety and tolerability of levofloxacin 500 mg twice daily with imipenem/cilastatin 1 g iv three-times daily in the treatment of hospitalized adult patients with clinically suspected bacteraemia/ sepsis. Levofloxacin patients could change from iv to oral administration after a minimum of 48 h iv treatment if clinical signs and symptoms of sepsis had improved. The primary efficacy analysis was based on the clinical and bacteriological response at clinical endpoint. A total of 503 patients were randomized and 499 included in the intent-to-treat population. The per-protocol population comprised 287 patients with bacteriologically proven infection. Clinical cure rates at clinical endpoint in the intent-to-treat population and per-protocol population were 77% (184/239) and 89% (125/140), respectively, for levofloxacin and 68% (178/260) and 85% (125/147), respectively, for imipenem/cilastatin. At follow-up, the cure rates in the per-protocol population were 84% for levofloxacin and 69% for imipenem/cilastatin. The 95% confidence interval for both populations showed that levofloxacin was as effective as imipenem/cilastatin. A satisfactory bacteriological response was obtained in 87% (96/110) of levofloxacin patients and 84% (97/116) of imipenem/cilastatin patients at clinical endpoint. Adverse events possibly related to the study drug were reported in 74 (31%) levofloxacin patients and 79 (30%) imipenem/cilastatin patients. There were no clinically appreciable differences between the treatment groups. Levofloxacin 500 mg twice daily, either iv or as sequential iv/oral therapy, was as effective and well tolerated as imipenem/cilastatin 1 g iv three-times daily in the treatment of hospitalized patients with suspected bacteraemia/sepsis.  (+info)

Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule. (6/118)

The aim of this study was to define mechanisms involved in the luminal uptake of inorganic mercury in the kidney using isolated perfused straight (S2) segments of the proximal tubule. When mercuric conjugates of glutathione (GSH), cysteinylglycine. or cysteine (containing 203Hg2+) were perfused through the lumen, the rates of luminal disappearance flux (JD) of inorganic mercury were approximately 39, 53, and 102 fmol/min per' min, respectively. Thus, the rates of luminal uptake of mercury are greater when the mercury is in the form of a mercuric conjugate of cysteine than in the form of a mercuric conjugate of cysteinylglycine or GSH. Addition of acivicin to the perfusate, to inhibit activity of the y-glutamyltransferase, caused significant reductions in the J,, for mercury in tubules perfused with mercuric conjugates of GSH. Addition of cilastatin, an inhibitor of dehydropeptidase- l (cysteinylglycinase) activity, caused significant reductions in the uptake of mercury in tubules perfused with mercuric conjugates of cysteinylglycine. These findings indicate that a significant amount of the luminal uptake of mercury, when mercuric conjugates of GSH are present in the lumen, is dependent on the activity of both y-glutamyltransferase and cysteinylglycinase. Finally, the JD for mercury in tubules perfused with mercuric conjugates of cysteine was reduced by approximately 50% when 3.0 mM L-lysine or 5.0 mM cycloleucine was added to the perfusate. It is concluded that these findings indicate that at least some of the luminal uptake of mercuric conjugates of cysteine occurs at the site of one or more amino acid transporters via a mechanism involving molecular homology.  (+info)

Acute necrotizing pancreatitis: treatment strategy according to the status of infection. (7/118)

OBJECTIVE: To determine benefits of conservative versus surgical treatment in patients with necrotizing pancreatitis. SUMMARY BACKGROUND DATA: Infection of pancreatic necrosis is the most important risk factor contributing to death in severe acute pancreatitis, and it is generally accepted that infected pancreatic necrosis should be managed surgically. In contrast, the management of sterile pancreatic necrosis accompanied by organ failure is controversial. Recent clinical experience has provided evidence that conservative management of sterile pancreatic necrosis including early antibiotic administration seems promising. METHODS: A prospective single-center trial evaluated the role of nonsurgical management including early antibiotic treatment in patients with necrotizing pancreatitis. Pancreatic infection, if confirmed by fine-needle aspiration, was considered an indication for surgery, whereas patients without signs of pancreatic infection were treated without surgery. RESULTS: Between January 1994 and June 1999, 204 consecutive patients with acute pancreatitis were recruited. Eighty-six (42%) had necrotizing disease, of whom 57 (66%) had sterile and 29 (34%) infected necrosis. Patients with infected necrosis had more organ failures and a greater extent of necrosis compared with those with sterile necrosis. When early antibiotic treatment was used in all patients with necrotizing pancreatitis (imipenem/cilastatin), the characteristics of pancreatic infection changed to predominantly gram-positive and fungal infections. Fine-needle aspiration showed a sensitivity of 96% for detecting pancreatic infection. The death rate was 1.8% (1/56) in patients with sterile necrosis managed without surgery versus 24% (7/29) in patients with infected necrosis (P <.01). Two patients whose infected necrosis could not be diagnosed in a timely fashion died while receiving nonsurgical treatment. Thus, an intent-to-treat analysis (nonsurgical vs. surgical treatment) revealed a death rate of 5% (3/58) with conservative management versus 21% (6/28) with surgery. CONCLUSIONS: These results support nonsurgical management, including early antibiotic treatment, in patients with sterile pancreatic necrosis. Patients with infected necrosis still represent a high-risk group in severe acute pancreatitis, and for them surgical treatment seems preferable.  (+info)

Treatment of severe nosocomial pneumonia: a prospective randomised comparison of intravenous ciprofloxacin with imipenem/cilastatin. (8/118)

BACKGROUND: A prospective multicentre study was undertaken to compare the efficacy of intravenous ciprofloxacin or imipenem in the treatment of severe nosocomial pneumonia requiring mechanical ventilation. METHODS: Patients with a clinical suspicion of pneumonia were randomised to receive either ciprofloxacin (800-1200 mg/day) or imipenem (2-4 g/day) in doses adjusted for renal function and specimens of the lower respiratory tract were taken. Patients were included in the study when specimens showed significant growth for potentially pathogenic microorganisms in quantitative bacterial cultures (n = 75, ciprofloxacin 41/75 (55%); imipenem 34/75 (45%)). The clinical and bacteriological success rates were the primary and secondary efficacy variables. An intent-to-treat analysis was performed for all randomised patients who received at least one dose of the study medication (n = 149, ciprofloxacin 72/149 (48%), imipenem 77/149 (52%)). RESULTS: The success rates were generally good, but neither the clinical success rates (ciprofloxacin, 29/41 (71%), imipenem, 27/34 (79%); 95% CI -10.8 to 28.1; p = 0.435) nor the bacteriological response rate (ciprofloxacin, 20/41 (49%), imipenem, 17/34 (50%); 95% CI -21.5 to 23.9; p = 1.0) were significantly different between the study arms. Pseudomonas aeruginosa was recovered in 26/75 patients (35%) and clinical (ciprofloxacin, 10/14 (71%), imipenem, 8/12 (67%); 95% CI -40.4 to 30.9; p = 1.0) and bacteriological response rates (ciprofloxacin, 7/14 (50%), imipenem, 3/12 (25%), 95% CI -60.9 to 10.9, p = 0.247) were not significantly different in this subgroup of patients. Resistance of Pseudomonas aeruginosa developed in 5/26 cases (19%), 1/14 (7%) to ciprofloxacin and 4/12 (33%) to imipenem (p = 0.147), and the mortality was 12/75 (16%) with no difference between treatment groups (ciprofloxacin, 8/41(24%), imipenem 4/34 (17%); p = 0.362). The clinical response was evaluable in 109/149 patients (73%) in the intent-to-treat analysis and was successful in 74/109 patients (68%). The clinical response rates were also not significantly different in the intent-to-treat analysis (ciprofloxacin, 34/52 (65%), imipenem, 40/57 (70%); 95% CI -12.8 to 22.3; p = 0.746). CONCLUSIONS: Treatment with either ciprofloxacin or imipenem was effective in a selected group of patients with microbiologically confirmed, severe nosocomial pneumonia requiring mechanical ventilation. Although no differences between the study medication could be documented in this trial, smaller differences between treatment arms may have been missed because of sample size limitations.  (+info)

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Evaluation of the appropriateness of imipenem/cilastatin prescription | IDREvaluation of the appropriateness of imipenem/cilastatin prescription | IDR
Evaluation of the appropriateness of imipenem/cilastatin prescription and dosing in a tertiary care hospital Wissam K Kabbara, George T Nawas, Wijdan H RamadanDepartment of Pharmacy Practice, School of Pharmacy, Lebanese American University, Byblos, Lebanon Background: Imipenem/cilastatin is an antibacterial agent of the carbapenem class of β-lactams that is known to have an extremely wide spectrum of activity against Gram-positive, Gram-negative, aerobic, anaerobic, and even multidrug-resistant strains. The objective of this study was to evaluate the appropriate use of imipenem/cilastatin in a local tertiary care hospital. The study assessed the indication both empirically and after the culture results were available, the dose and dose adjustment in renal failure, as well as the incidence of seizure in hospitalized patients receiving imipenem/cilastatin. Methods: This observational study was conducted in a tertiary care hospital over a 3-month period. The treatment of 100 patients with imipenem
https://www.dovepress.com/evaluation-of-the-appropriateness-of-imipenemcilastatin-prescription-a-peer-reviewed-article-IDR
A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired...A Study of the Safety and Effectiveness of Levofloxacin Compared With Imipenem/Cilastatin in Patients With Pneumonia Acquired...
Despite advances in prevention and treatment, hospital-acquired pneumonia remains a significant problem as the second most common infection acquired in the hospital and the most deadly (20%-50% of patients who acquire pneumonia while in the hospital die from complications of pneumonia). Levofloxacin has been shown in clinical trials to be effective against a number of different bacteria, including those found to be common and uncommon causes of pneumonia. This multicenter, open-label study evaluates the safety and effectiveness of levofloxacin as compared with imipenem/cilastatin, another type of antibiotic treatment, in patients with pneumonia acquired in the hospital. Patients receive treatment for a total of 7-15 days, initially with levofloxacin or imipenem/cilastatin, administered slowly through a vein. If patients respond positively to either drug, treatment may be changed to levofloxacin or ciprofloxacin (if initially treated with imipenem/cilastatin), to be taken by mouth. Certain ...
https://clinicaltrials.gov/ct2/show/NCT00236834
Cilastatin - WikipediaCilastatin - Wikipedia
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria; more precisely the carbapenem family of antibiotics. This property is due to the physico-chemical similarities between membrane dipeptidase (MDP), the compound it is usually set to target, and the bacterial metallo-beta-lactamase carried by the CphA gene Therefore, cilastatin is considered a beta-lactamase inhibitor, not an antibiotic per se. But as with other combinations of an ...
https://en.wikipedia.org/wiki/Cilastatin
Imipenem/cilastatin - WikipediaImipenem/cilastatin - Wikipedia
Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage.[11] Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Imipenem/cilastatin, like other carbapenems, binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. ...
https://en.wikipedia.org/wiki/Imipenem/cilastatin
Cilastatin; Imipenem (Cilastatin Sodium; Imipenem) RanbaxyCilastatin; Imipenem (Cilastatin Sodium; Imipenem) Ranbaxy
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Cilastatin; Imipenem (Cilastatin Sodium; Imipenem) Jodas ExpoimCilastatin; Imipenem (Cilastatin Sodium; Imipenem) Jodas Expoim
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Dual drug delivery of vancomycin and imipenem/cilastatin by coaxial nanofibers for treatment of diabetic foot ulcer infections ...
Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:111975. doi: 10.1016/j.msec.2021.111975. Epub 2021 Feb 15.. ABSTRACT. Diabetic foot ulcer infections are the main causes of hospitalization in diabetics. The present study aimed to develop vancomycin and imipenem/cilastatin loaded core-shell nanofibers to facilitate the treatment of diabetic foot ulcers. Therefore, novel core-shell nanofibers composed of polyethylene oxide, chitosan, and vancomycin in shell and polyvinylpyrrolidone, gelatin, and imipenem/cilastatin in core compartments were prepared using the electrospinning technique. The nanofibers were characterized using scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, tensile test, and drug release. The antibacterial activity of drug-loaded nanofibers in different drugs concentrations was evaluated against Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa by disk diffusion method. Furthermore, ...
https://www.infectoforum.net/dual-drug-delivery-of-vancomycin-and-imipenem-cilastatin-by-coaxial-nanofibers-for-treatment-of-diabetic-foot-ulcer-infections/
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CILASTATIN SODIUM (CAS 81129-83-1) Market Research Report 2017CILASTATIN SODIUM (CAS 81129-83-1) Market Research Report 2017
The report generally describes cilastatin sodium, examines its uses, production methods, patents. CILASTATIN SODIUM market situation is overviewed;
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Primaxin (imipenem/cilastatin) dosing, indications, interactions, adverse effects, and morePrimaxin (imipenem/cilastatin) dosing, indications, interactions, adverse effects, and more
Medscape - Indication-specific dosing for Primaxin (imipenem/cilastatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
https://reference.medscape.com/drug/primaxin-imipenem-cilastatin-342562
imipenem and cilastatin - WellSpan Health Libraryimipenem and cilastatin - WellSpan Health Library
Imipenem is an antibiotic that fights bacteria. Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys. Imipenem and cilastatin is a combination medicine used to treat severe infections of the lower respiratory tract, skin, stomach, or female reproductive organs...
http://www.wellspan.org/health-library/Document.aspx?id=d00082a1
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PRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPR - ONAPRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPR - ONA
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PRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPRPRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPR
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PRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPRPRIMAXIN IM 500 (Cilastatin sodium,Imipenem) dosage, indication, interactions, side effects | EMPR
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Selected Safety Information for RECARBRIO™ (imipenem, cilastatin, and relebactam)Selected Safety Information for RECARBRIO™ (imipenem, cilastatin, and relebactam)
Review the selected safety information for RECARBRIO™ (imipenem, cilastatin, and relebactam), and read the prescribing information for RECARBRIO before prescribing.
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cilastatin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYcilastatin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. cilastatin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=clinical&ligandId=5166
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Carbapenem
Imipenem, the first clinically used carbapenem, was developed at Merck and Co. It was approved for use in the United States in 1985.[20] Imipenem is hydrolyzed in the mammalian kidney by a dehydropeptidase enzyme to a nephrotoxic intermediate, and thus is co-formulated with the dehydropeptidase inhibitor cilastatin.[5] Imipenem is available in both intravenous[21] and intramuscular[22] formulations.. Meropenem is stable to mammalian dehydropeptidases and does not require co-administration of cilastatin. It was approved for use in the United States in 1996. In most indications it is somewhat more convenient to administer than imipenem, 3 times a day rather than 4. Doses of less than one gram may be administered as an IV bolus, whereas imipenem is usually administered as a 20-minute to one hour infusion. Meropenem is somewhat less potent than imipenem against gram-positive pathogens, and somewhat more potent against gram-negative infections. Unlike imipenem, which produced an unacceptable rate of ...
https://readtiger.com/wkp/en/Carbapenem
CiNii Articles - IKEDA KIMIAKI
COMPARISON BETWEEN MONOTHERAPY WITH IMIPENEM/CILASTATIN SODIUM (IPM/CS) AND COMBINATIONS OF IPM/CS AND OTHER DRUGS FOR TREATING BACTERIAL INFECTIONS IN PATIENTS WITH HEMATOPOIETIC DISORDERS （1996 ...
https://ci.nii.ac.jp/author?q=IKEDA+KIMIAKI
Human Metabolome Database: Showing metabocard for Cilastatin (HMDB0015535)Human Metabolome Database: Showing metabocard for Cilastatin (HMDB0015535)
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3-azido- 3-deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by ...
http://www.hmdb.ca/metabolites/HMDB15535
Monobactams and Carbapenims - howMedMonobactams and Carbapenims - howMed
Imipenem is metabolized in renal tubules by dehydropeptidase enzyme. Cilastatin is dehydropeptidase inhibitor, it may be combined so that enough drug reaches the site of action ...
http://howmed.net/pharmacology/monobactams-and-carbapenims/
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vancomycin-阿摩線上測驗vancomycin-阿摩線上測驗
10 下列抗生素中，何者容易被renal tubular dehydropeptidase 破壞，所以常併用cilastatin 來抑制此酵素，以提高此抗生素在血中之濃度 ...
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Neutropenic Fever Empiric Therapy Overview Archives - Bookkeeping Services And Quality Tax, Accounting, Payroll Services-...Neutropenic Fever Empiric Therapy Overview Archives - Bookkeeping Services And Quality Tax, Accounting, Payroll Services-...
7] :. Piperacillin-tazobactam 4.5 g IV q6h or. Cefepime 2 g IV q8h or. Meropenem 1 g IV q8h or. Imipenem-cilastatin 500 mg IV q6h. No single agent has shown superiority in the empiric treatment of febrile neutropenia.. Second-line dual therapy: The use of dual therapy in high-risk patients is indicated for complicated cases (hypotension or pneumonia) or suspected or proven antimicrobial resistance. Appropriate antibiotic regimens in this setting include the following:. Piperacillin-tazobactam 4.5 g IV q6h plus an aminoglycoside (see below) or. Cefepime 2 g IV q8h plus an aminoglycoside (see below) or. Meropenem 1 g IV q8h plus an aminoglycoside (see below) or. Imipenem-cilastatin 500 mg IV q6h plus an aminoglycoside (see below). Aminoglycoside options:. Gentamicin 2 mg/kg IV q8h or 5 mg/kg q24h or. Amikacin 15 mg/kg/day or. Tobramycin 2 mg/kg q8h. Indications for the empiric addition of vancomycin (15 mg/kg IV q12h) to drug regimens listed above:. Clinically suspected serious catheter-related ...
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Wide spectrum action against aerobes & anaerobes More active than ceftazidime Wide spectrum of action including gram +ve & gram-ye coverage Cilastatin diminishes adverse reaction associated with imipenem administration   Dosage : Adults : In terms of Impenem ,1.2 g Daily in Divided Doses every 6-8 Irs given Via I.V. infusion Children : 3WS 15-25 mg/Kg Every 6 Hrs by IV Infusion Surgical Prophylaxis In Terms of Impenem 19 given on induction of anaesthesia followed by 1g 3 Hrs Later   Indications : Infections In Dialysis Patients  UT Infections  LRT Infections  Endocarditis  Gynaecological Infection  Diabetic Foot Infection  Intra Abdominal Infection  Bone & Joint Infections  Skin & Skin Structure Infection  Nosocomial ...
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Tissue distribution of the drug (therapeutic concen- neonates with poor aminoglycoside kinetics or docu- trations must be reached at the site of infection) mented multiresistant infections, and the drug shouldbe administered at 11 mg/kg IV or IM q8h. A new class Foals with pneumonia secondary to septicemia require of synthetic β-lactams, the carbapenems, exhibits a high broad-spectrum therapy because of either gram-nega- degree of stability in the presence of β-lactamases and tive or gram-positive involvement. Older foals with may be useful in critically ill foals with documented uncomplicated pneumonia may initially be treated with multiresistant infections. Imipenem-cilastatin has been a gram-positive regimen, but a poor response to treat- used in foals at an empiric dosage of 5 to 10 mg/kg IM ment represents a clear indication for institution of bid with apparent safety and efficacy.6 Intravenous broad-spectrum therapy. Evidence of pulmonar y administration substantially increases the ...
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Does tigecycline have a place in therapy for hospital-acquired pneumonia or ventilator-associated pneumonia? - LECOMDoes tigecycline have a place in therapy for hospital-acquired pneumonia or ventilator-associated pneumonia? - LECOM
Tigecycline is FDA approved in patients 18 years of age or older for the treatment of complicated skin and skin structure infections (SSSI) caused by susceptible organisms, including methicillin-resistant Staphylococcus aureus and vancomycin sensitive Enterococcus faecalis. In addition, it is indicated for the treatment of complicated intra-abdominal infections (cIAI) and community-acquired pneumonia (CAP) caused by susceptible organisms.1. To date, tigecycline does not have a place in therapy for hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP) due to an increase in mortality that was observed when using tigecycline in these conditions. A search of the medical literature returned several supportive studies.. Freire, et al. (2010) conducted a phase 3, randomized, double-blind trial comparing tigecycline with imipenem/cilastatin for the treatment of HAP.2 Patients were given an initial dose of 100 mg IV, followed by 50 mg IV every 12 hours. The tigecycline regimen was ...
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Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection |...Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection |...
Study design.This was a prospective, multicenter, double-blind, randomized controlled trial (MK-7655 Protocol 004, NCT01506271) conducted from 16 November 2012 through 12 August 2014 at 45 sites in 20 countries. The original protocol and all amendments were approved by the relevant institutional review board or independent ethics committee at each study center. The study was conducted in accordance with the protocol, Good Clinical Practice guidelines, and the Declaration of Helsinki. Subjects provided written informed consent before any study procedures were performed.. Study participants were adults (≥18 years of age) with clinically suspected and/or bacteriologically documented cIAI requiring hospitalization and treatment with i.v. antibiotic therapy. Postoperative (or intraoperative) enrollment was encouraged. If preoperative data were available that strongly suggested an appropriate diagnosis for entry (see Appendix S1 in the supplemental material), then preoperative enrollment was ...
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The Nutshell EPO Revokes Broads CRISPR Patent Shortly after ruling out the earliest priority dates on a foundational patent for CRISPR gene-editing technology, the European Patent Office rescinded the patent entirely-and more are likely to follow.. ...
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Ampicillin sulbactam in pregnancy - How to take dapoxetine 60
The risk of pregnancy increases with each. Ampicillin and Sulbactam and aminoglycosides should not be reconstituted together due to the in vitro inactivation of.Is ampicillin safe in pregnancy. Talk to your doctor about any side effect that seems unusual or. Ceftriaxone attenuates alcohol intake take it Tell your level.1. Chemical and Physical Data 1.1 Synonyms ehem. clavulanic acid and sulbactam (Foulds, 1986;. The disposition of ampicilln is altered in pregnancy.. IC Fertility Pregnancy Immunochemistry Fertility/Pr Pregnanc. AMPICILLIN AM 256 WW S30. SULBACTAM SUL 256 WW S30.Ampicillin sulbactam can be used as. Which organ made during pregnancy provides nutrients to and removes wastes from the fetus as well as producing hormones.Pregnancy cat. B Appears safe in pregnancy [1] Legal status. Co-amoxiclav (Amoxicillin/clavulanic acid) 1 · Imipenem/cilastatin 1 · Ampicillin/sulbactam.wh0cd594755 ,a href=http://ampicillinsulbactam.review/,ampicillin sulbactam. Women need to take their ...
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EP 1113016 A4 20011212 - CARBAPENEM COMPOUNDSEP 1113016 A4 20011212 - CARBAPENEM COMPOUNDS
387552322 - EP 1113016 A4 2001-12-12 - CARBAPENEM COMPOUNDS - [origin: WO0015640A1] Carbapenem compounds represented by general formula (I); pharmacologically acceptable salts of the same; and antibacterial agents containing these compounds or salts as the active ingredient (wherein R is hydrogen or optionally substituted lower alkyl; and n is an integer of 1 or 2). The compounds and salts exhibit a potent antibacterial activity and are excellent in the resistance to beta -lactamase and renal dehydropeptidase.[origin: WO0015640A1] Carbapenem compounds represented by general formula (I); pharmacologically acceptable salts of the same; and antibacterial agents containing these compounds or salts as the active ingredient (wherein R is hydrogen or optionally substituted lower alkyl; and n is an integer of 1 or 2). The compounds and salts exhibit a potent antibacterial activity and are excellent in the resistance to beta -lactamase and renal dehydropeptidase.
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AID 56107 - Stability towards hog kidney dehydropeptidase (DHP) expressed as relative hydrolysis to imipenem - PubChemAID 56107 - Stability towards hog kidney dehydropeptidase (DHP) expressed as relative hydrolysis to imipenem - PubChem
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Complicated Intra-Abdominal Infections Market Size & Share | Complicated Intra-Abdominal Infections Market Research ReportComplicated Intra-Abdominal Infections Market Size & Share | Complicated Intra-Abdominal Infections Market Research Report
Complicated Intra-Abdominal Infections market research report presents a detailed analysis of the Complicated Intra-Abdominal Infections market size and share, epidemiology, key companies and pipeline insights
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Complicated Intra-Abdominal Infections - Pipeline Review, H2 2014 | Aug 28, 2014 - ReleaseWireComplicated Intra-Abdominal Infections - Pipeline Review, H2 2014 | Aug 28, 2014 - ReleaseWire
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Tetraphase Pharmaceuticals Inc. (via Public) / Tetraphase Pharmaceuticals Highlights Data at Upcoming American Society for...Tetraphase Pharmaceuticals Inc. (via Public) / Tetraphase Pharmaceuticals Highlights Data at Upcoming American Society for...
About XERAVATM XERAVA(eravacycline for injection) is a tetracycline class antibacterial indicated for the treatment of complicated intra-abdominal infections (cIAI) in patients 18 years of age and older. XERAVA was investigated for the treatment of cIAI as part of the Companys IGNITE (Investigating Gram-Negative Infections Treated with Eravacycline) Phase 3 program. In the first pivotal Phase 3 trial in patients with cIAI, twice-daily intravenous (IV) XERAVA met the primary endpoint by demonstrating statistical non-inferiority of clinical response compared to ertapenem and was well-tolerated. In the second Phase 3 clinical trial in patients with cIAI, twice-daily IV XERAVA met the primary endpoint by demonstrating statistical non-inferiority of clinical response compared to meropenem and was well-tolerated. In both trials, XERAVA achieved high cure rates in patients with Gram-negative pathogens, including resistant isolates. Indications and Usage XERAVA is indicated for the treatment of ...
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Moxifloxacin i.v. in the Treatment of Complicated Intra-Abdominal Infection (cIAI) - Tabular View - ClinicalTrials.govMoxifloxacin i.v. in the Treatment of Complicated Intra-Abdominal Infection (cIAI) - Tabular View - ClinicalTrials.gov
This study is a local, prospective, open-label, company-sponsored, non interventional, multi-center study. Patients documented must suffer from a cIAI and take at least one dose of Moxifloxacin infusion.The primary objective is to define the types of cIAI infections that require Moxifloxacin i.v. therapy in China ...
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CilastatinCilastatin
Imipenem alone is an effective antibiotic and can be given without cilastatin. Cilastatin itself does not have antibiotic ... Cilastatin inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for ... Thus imipenem/cilastatin, like amoxicillin/clavulanic acid, is a commonly used combination product. Keynan S, Hooper NM, Felici ... Cilastatin can therefore be combined intravenously with imipenem in order to protect it from degradation, prolonging its ...
https://en.wikipedia.org/wiki/Cilastatin
Jeannette BrownJeannette Brown
She worked to develop the compound cilastatin sodium. Cilastatin is an inhibitor of renal dehydropeptidase. Since the ... "Cilastatin". www.drugbank.ca. Retrieved 2020-04-24. Neal, Sharon L. (2 April 2012). "Black Women, Chemistry Pioneers". Chemical ... This combination creates the antibiotic Primaxin (imipenem/cilastatin), which is used to treat severe internal infections, as ... antibiotic, imipenem, is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin is used in combination with ...
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ImipenemImipenem
"Imipenem-Cilastatin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. NCBI Bookshelf. 17 January 2017 ... U.S. Patent 4,194,047 Clissold SP, Todd PA, Campoli-Richards DM (March 1987). "Imipenem/cilastatin. A review of its ... Kahan FM, Kropp H, Sundelof JG, Birnbaum J (December 1983). "Thienamycin: development of imipenen-cilastatin". The Journal of ... Clissold SP, Todd PA, Campoli-Richards DM (March 1987). "Imipenem/cilastatin. A review of its antibacterial activity, ...
https://en.wikipedia.org/wiki/Imipenem
Β-Lactamase inhibitorΒ-Lactamase inhibitor
"Cilastatin/imipenem/relebactam - AdisInsight". Springer International Publishing AG. Retrieved 29 April 2016. "FDA approves new ... used in combination with imipenem/cilastatin (Recarbrio). β-lactamase inhibitors with other types of non β-lactam cores: ...
https://en.wikipedia.org/wiki/Β-Lactamase_inhibitor
Membrane dipeptidaseMembrane dipeptidase
Inhibitors include bestatin and cilastatin. Dipeptidase 1 (DPEP1) Dipeptidase 2 (DPEP2) Dipeptidase 3 (DPEP3) Campbell BJ, Lin ...
https://en.wikipedia.org/wiki/Membrane_dipeptidase
CarbapenemCarbapenem
Meropenem is stable to mammalian dehydropeptidases and does not require co-administration of cilastatin. It was approved for ... Edwards SJ, Emmas CE, Campbell HE (2005). "Systematic review comparing meropenem with imipenem plus cilastatin in the treatment ... Discovery and development of imipenem/cilastatin". American Journal of Medicine. 78 (6A): 3-21. doi:10.1016/0002-9343(85)90097- ... and thus is co-formulated with the dehydropeptidase inhibitor cilastatin. Imipenem is available in both intravenous and ...
https://en.wikipedia.org/wiki/Carbapenem
Cyclopentenone prostaglandinsCyclopentenone prostaglandins
Clinical and pharmacokinetic study of imipenem/cilastatin in children and newborn infants]". Pathologie-biologie. 37 (5): 485- ...
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MeropenemMeropenem
Unlike imipenem, it is stable to dehydropeptidase-1, so can be given without cilastatin. In 2016, a synthetic peptide- ...
https://en.wikipedia.org/wiki/Meropenem
CapnocytophagaCapnocytophaga
The imipenem/cilastatin, clindamycin, or combinations containing an inhibitor of beta-lactamases (i.e. Augmentin, Unasyn) are ...
https://en.wikipedia.org/wiki/Capnocytophaga
AcinetobacterAcinetobacter
Wood GC, Hanes SD, Croce MA, Fabian TC, Bougher BA (2002). "Comparison of ampicillin-sulbactam and imipenem-cilastatin for the ...
https://en.wikipedia.org/wiki/Acinetobacter
ErtapenemErtapenem
Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations". Therapeutic Drug Monitoring. 38 (5): 587-92. doi: ...
https://en.wikipedia.org/wiki/Ertapenem
ThienamycinThienamycin
To prevent its rapid degradation, imipenem is normally coadministered with cilastatin, an inhibitor of this enzyme. Nicolaou, K ...
https://en.wikipedia.org/wiki/Thienamycin
RelebactamRelebactam
In the United States, relebactam is approved for use in the combination imipenem/cilastatin/relebactam (Recarbrio). Avibactam ...
https://en.wikipedia.org/wiki/Relebactam
Simmons-Smith reactionSimmons-Smith reaction
The β-lactamase inhibitor Cilastatin provides an instructive example of Simmons-Smith reactivity in natural products synthesis ...
https://en.wikipedia.org/wiki/Simmons–Smith_reaction
PiperacillinPiperacillin
Schmitt DV, Leitner E, Welte T, Lode H (June 2006). "Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of ... Ong CT, Kuti JL, Nicolau DP (2005). "Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam ... "Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for ...
https://en.wikipedia.org/wiki/Piperacillin
Intermolecular metal-catalyzed carbenoid cyclopropanationsIntermolecular metal-catalyzed carbenoid cyclopropanations
... such as cilastatin.(12) Tandem cyclopropanation/fragmentation is a key step in the synthesis of 12-hydroxyeicosatetraenoic acid ...
https://en.wikipedia.org/wiki/Intermolecular_metal-catalyzed_carbenoid_cyclopropanations
Pediatric Trials NetworkPediatric Trials Network
July 2013). "Adverse events associated with meropenem versus imipenem/cilastatin therapy in a large retrospective cohort of ...
https://en.wikipedia.org/wiki/Pediatric_Trials_Network
Drug of last resortDrug of last resort
... such as imipenem/cilastatin) - used as a drug of last resort for a variety of different bacterial infections; Ceftobiprole and ...
https://en.wikipedia.org/wiki/Drug_of_last_resort
CefiderocolCefiderocol
25 October 2018). "Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by ... Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections (APEKS-cUTI)" at ClinicalTrials.gov Portal: Medicine (Source ... or another antibacterial drug called imipenem/cilastatin. Both treatments were given intravenously for 7-14 days and neither ... cure or improvement in their symptoms related to cUTI and a negative urine culture test in comparison to imipenem/cilastatin. ...
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Febrile neutropeniaFebrile neutropenia
... meropenem and imipenem/cilastatin), or piperacillin/tazobactam for high-risk patients and amoxicillin-clavulanic acid and ...
https://en.wikipedia.org/wiki/Febrile_neutropenia
List of antibioticsList of antibiotics
Meropenem/vaborbactam Imipenem/cilastatin/relebactam Carbapenems: (meropenem, imipenem/cilastatin - NOT ertapenem) Others: ...
https://en.wikipedia.org/wiki/List_of_antibiotics
WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
For use in combination regimens for eradication of H. pylori in adults Imipenem/cilastatin is an alternative for complicated ... 5 years Terizidone may be an alternative Prothionamide may be an alternative Imipenem/cilastatin may be an alternative For ... use only in patients with HIV receiving protease inhibitors For use only in combination with meropenem or imipenem/cilastatin ...
https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines
Multidrug-resistant tuberculosisMultidrug-resistant tuberculosis
... imipenem-cilastatin/meropenem, amikacin/streptomycin, ethionamide/prothionamide, p-aminosalicylic acid) For patients with RR-TB ...
https://en.wikipedia.org/wiki/Multidrug-resistant_tuberculosis
List of MeSH codes (D02)List of MeSH codes (D02)
... cilastatin MeSH D02.455.426.392.368.533.450 - hypoglycins MeSH D02.455.426.559 - hydrocarbons, aromatic MeSH D02.455.426.559. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
List of MeSH codes (D10)List of MeSH codes (D10)
... cilastatin MeSH D10.251.355.325.240 - crotonic acids MeSH D10.251.355.325.240.240 - crotonates MeSH D10.251.355.325.300 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D10)
List of drugs: CiList of drugs: Ci
... cilastatin (INN) cilazapril (INN) cilazaprilat (INN) cilengitide (USAN) cilmostim (INN) cilnidipine (INN) cilobamine (INN) ...
https://en.wikipedia.org/wiki/List_of_drugs:_Ci
ATC code J01ATC code J01
... cilastatin and relebactam J01DI01 Ceftobiprole medocaril J01DI02 Ceftaroline fosamil J01DI03 Faropenem J01DI04 Cefiderocol ... Meropenem J01DH03 Ertapenem J01DH04 Doripenem J01DH05 Biapenem J01DH06 Tebipenem pivoxil J01DH51 Imipenem and cilastatin ...
https://en.wikipedia.org/wiki/ATC_code_J01
Imp (disambiguation)Imp (disambiguation)
... a camera on board the Mars Pathfinder lander imipenem/cilastatin, an antibiotic combination Interplanetary Monitoring Platform ...
https://en.wikipedia.org/wiki/Imp_(disambiguation)
Timeline of antibioticsTimeline of antibiotics
... imipenem/cilastatin/relebactam 2019 - cefiderocol Timeline of medicine and medical technology List of antibiotics, grouped by ... imipenem/cilastatin, the first carbapenem 1985 - ofloxacin 1986 - mupirocin 1986 - aztreonam 1986 - cefoperazone/sulbactam 1986 ...
https://en.wikipedia.org/wiki/Timeline_of_antibiotics
Imipenem and Cilastatin Injection: MedlinePlus Drug InformationImipenem and Cilastatin Injection: MedlinePlus Drug Information
Imipenem and Cilastatin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using imipenem and cilastatin injection,. *tell your doctor and pharmacist if you are allergic to imipenem or cilastatin ... Use imipenem and cilastatin injection exactly as directed. Do not use more or less of it or use it more often than prescribed ... Imipenem and cilastatin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go ...
https://medlineplus.gov/druginfo/meds/a686013.html
Imipenem/Cilastatin - Fresenius Kabi Great Britain
Imipenem/Cilastatin Please note that due to the Association of the British Pharmaceutical Industry body information on ...
https://www.fresenius-kabi.com/gb/products/imipenem-cilastatin-kabi
Acute Pyelonephritis Medication: Sulfonamides, Fluoroquinolones, Cephalosporins, Second Generation, Cephalosporins, Third...Acute Pyelonephritis Medication: Sulfonamides, Fluoroquinolones, Cephalosporins, Second Generation, Cephalosporins, Third...
Imipenem/cilastatin has bactericidal activity against a wide range of gram-negative and gram-positive organisms. It is an ... have been shown to respond to treatment with imipenem-cilastatin. The general dosing recommendation is 500 mg IV every 6 hours ...
https://www.medscape.com/answers/245559-22214/which-medications-in-the-drug-class-cephalosporins-third-generation-are-used-in-the-treatment-of-acute-pyelonephritis
Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal...Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal...
imipenem/cilastatin in hospitalized Chinese patients with cIAIs. In this phase 3, multicenter, open-label study, patients were ... 53.9% after imipenem/cilastatin therapy (P < 0.001), primarily due to gastrointestinal-related events, especially nausea ( ... Because the study was not powered to demonstrate non-inferiority between tigecycline and imipenem/cilastatin, no formal ... In the microbiologically evaluable population, 86.5% (45 of 52) of tigecycline- and 97.9% (47 of 48) of imipenem/cilastatin- ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-10-217/peer-review
Imipenem/cilastatin efficacy evaluated<...Imipenem/cilastatin efficacy evaluated<...
Imipenem/cilastatin efficacy evaluated. Drug Intelligence and Clinical Pharmacy. 1985;19(11):840-841. doi: 10.1177/ ... Bailie, G. R. ; Crossley, K. B. ; Rotschafer, J. C. / Imipenem/cilastatin efficacy evaluated. In: Drug Intelligence and ... Bailie, G. R., Crossley, K. B., & Rotschafer, J. C. (1985). Imipenem/cilastatin efficacy evaluated. Drug Intelligence and ... Imipenem/cilastatin efficacy evaluated. / Bailie, G. R.; Crossley, K. B.; Rotschafer, J. C. ...
https://experts.umn.edu/en/publications/imipenemcilastatin-efficacy-evaluated
Serratia Medication: AntibioticsSerratia Medication: Antibiotics
Imipenem-cilastatin (Primaxin). *View full drug information. Carbapenem is used for treatment of multiple-organism infections ...
https://emedicine.medscape.com/article/228495-medication
Imipenem cilastatin injection Exporter, Manufacturer Supplier, GujaratImipenem cilastatin injection Exporter, Manufacturer Supplier, Gujarat
APINDEX PHARMACEUTICALS PRIVATE LIMITED - Prominent Exporter,Manufacturer, Supplier of Imipenem cilastatin injection based in ... Buy Imipenem cilastatin injection at reasonable price. ...
http://m.apindexpharma.com/imipenem-cilastatin-injection-7539262.html
Drug Trials Snapshot: AVYCAZ (cUTI) | FDADrug Trials Snapshot: AVYCAZ (cUTI) | FDA
... and tolerability of AVYCAZ versus imipenem-cilastatin in the treatment of adults with cUTI. Patients were stratified based on ... and the other half was given another antibiotic called imipenem-cilastatin. Neither the patients nor the health care ... professionals administering the drug knew which patients were taking AVYCAZ and which were taking imipenem-cilastatin until ...
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshot-avycaz-cuti
Will There Be Drug Shortages Due To The Coronavirus? Complete List Of Medication ShortagesWill There Be Drug Shortages Due To The Coronavirus? Complete List Of Medication Shortages
Imipenem and Cilastatin for Injection, USP. *Ketamine Injection. *Ketoprofen Capsules. *Ketorolac Tromethamine Injection ...
https://www.ibtimes.com/will-there-be-drug-shortages-due-coronavirus-complete-list-medication-shortages-2938311
Imipenem 500 mg+ Cilastatin 500 mg.Imipenem 500 mg+ Cilastatin 500 mg.
Imipenem 500 mg+ Cilastatin 500 mg in Budaun :- Rednirus Mart is a online portal and commercial marketplace where people can ... easily search for the best Imipenem 500 mg+ Cilastatin 500 mg in... ... Imipenem 500 Cilastatin 500 MG injections pcd Franchise Suppliers & Ma... Looking for Imipenem 500 + Cilastatin 500 MG ... Imipenem 500 With Cilastatin 500 MG PCD Pharma Supplier & Manufacturin... Healthkind Pharmaceuticals is one of the top PCD ...
https://www.rednirusmart.com/budaun/imipenem-500-mg-cilastatin-500-mg
Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.
Imipenem/cilastatin and meropenem are carbapenem antibiotics that are infused intravenously (IV) over 30 to 45 min. We ... Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.. ... Eighteen healthy adults in a randomized, 4-phase, crossover study received 1000 mg of imipenem/cilastatin or meropenem as a ... Three-hour infusions of imipenem/cilastatin and meropenem improved the cumulative probability of target attainment for a ...
http://webmail.druglib.com/abstract/le/lee-ls_diagn-microbiol-infect-dis_20101100.html
Thieme E-Journals - Pharmaceutical Fronts / AbstractThieme E-Journals - Pharmaceutical Fronts / Abstract
imipenem - cilastatin sodium - stability - oxidation - free water Publication History. Article published online:. 04 July 2022 ... This study led to a better understanding of the degradation mechanism of imipenem and cilastatin sodium, and could provide a ... The study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to ... Effect of Oxygen and Water on the Stability of Imipenem and Cilastatin Sodium for Injection. Meng Zhang ...
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1750043
Mara Dinsmoor, MD, MPH | NorthShoreMara Dinsmoor, MD, MPH | NorthShore
Imipenem-cilastatin. Obstet Gynecol Clin North Am, 19:475-482, 1992.. *Dinsmoor MJ. Ophthalmia neonatorum. Infection Protocols ...
https://www.northshore.org/research-institute/investigators/mara-dinsmoor-md-mph/
Hematoma and abscess formation caused by Mycoplasma hominis following | IJWHHematoma and abscess formation caused by Mycoplasma hominis following | IJWH
... cilastatin sodium. Because the exudate exhibited M. hominis growth in an anaerobic environment, we administered the quinolone ... cilastatin sodium. Because the exudate exhibited M. hominis growth in an anaerobic environment, we administered the quinolone ...
https://www.dovepress.com/hematoma-and-abscess-formation-caused-by-mycoplasma-hominis-following--peer-reviewed-fulltext-article-IJWH
BCG Vaccine (Tice strain) (BCG vaccine live) dosing, indications, interactions, adverse effects, and moreBCG Vaccine (Tice strain) (BCG vaccine live) dosing, indications, interactions, adverse effects, and more
imipenem/cilastatin/relebactam. Monitor Closely (1)imipenem/cilastatin/relebactam decreases effects of BCG vaccine live by ... imipenem/cilastatin. Monitor Closely (1)imipenem/cilastatin decreases effects of BCG vaccine live by pharmacodynamic antagonism ... imipenem/cilastatin. imipenem/cilastatin decreases effects of BCG vaccine live by pharmacodynamic antagonism. Modify Therapy/ ... imipenem/cilastatin/relebactam. imipenem/cilastatin/relebactam decreases effects of BCG vaccine live by pharmacodynamic ...
https://reference.medscape.com/drug/tice-bcg-vaccine-tice-strain-343147
Docetaxel - Collaborative Medicine Development NetworkDocetaxel - Collaborative Medicine Development Network
IMIPENEM+CILASTATIN. Add to compare. Small volume products for US market. Add to compare. ...
https://farmavita.net/market/advert/docetaxel-431
Aminophylline Injection (aminophylline dihydrate) dose, indications, adverse effects, interactions... from PDR.netAminophylline Injection (aminophylline dihydrate) dose, indications, adverse effects, interactions... from PDR.net
Imipenem; Cilastatin: (Moderate) Generalized seizures have occurred in patients who were receiving imipenem-cilastatin ... Imipenem; Cilastatin; Relebactam: (Moderate) Generalized seizures have occurred in patients who were receiving imipenem- ... Moderate) Generalized seizures have occurred in patients who were receiving imipenem-cilastatin concomitantly with theophylline ... Moderate) Generalized seizures have occurred in patients who were receiving imipenem-cilastatin concomitantly with theophylline ...
https://www.pdr.net/drug-summary/Aminophylline-Injection-aminophylline-dihydrate-3141
Jolivette (norethindrone) dose, indications, adverse effects, interactions... from PDR.netJolivette (norethindrone) dose, indications, adverse effects, interactions... from PDR.net
Imipenem; Cilastatin; Relebactam: (Moderate) It would be prudent to recommend alternative or additional contraception when oral ... Imipenem; Cilastatin: (Moderate) It would be prudent to recommend alternative or additional contraception when oral ...
https://pdr.net/drug-summary/Jolivette-norethindrone-2995
Vasquez Jimenez W[Author] - Search Results - PubMedVasquez Jimenez W[Author] - Search Results - PubMed
Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. ...
https://pubmed.ncbi.nlm.nih.gov/?term=Vasquez%20Jimenez%20W%5BAuthor%5D&cauthor=true&cauthor_uid=23870278
Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-Dependent Manner in Enterobacter Cloacae | Research SquareCefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-Dependent Manner in Enterobacter Cloacae | Research Square
Imipenem/Cilastatin. Drugs. 1992; 44(3):408-444.. *Saini S, Aparna, Gupta N, Mahajan A, Saini OP. Antibiotic susceptibility of ...
https://www.researchsquare.com/article/rs-919621/v1
CYTOVENE IV - Clinical AdvisorCYTOVENE IV - Clinical Advisor
Avoid imipenem-cilastatin (seizures). Monitor renal function with concomitant cyclosporine, amphotericin B. Caution with ...
https://www.clinicaladvisor.com/drug/cytovene-iv/
Bromelain | CS Mott Childrens Hospital | Michigan MedicineBromelain | CS Mott Children's Hospital | Michigan Medicine
Imipenem-Cilastatin. When taken with amoxicillin, bromelain was shown to increase absorption of amoxicillin in humans. When 80 ... Imipenem-Cilastatin-Relebactam. When taken with amoxicillin, bromelain was shown to increase absorption of amoxicillin in ...
https://www.mottchildren.org/health-library/hn-2817009
Use of Penicillins in Animals - Pharmacology - Merck Veterinary ManualUse of Penicillins in Animals - Pharmacology - Merck Veterinary Manual
Therefore, imipenem is typically combined with a dehydropeptidase inhibitor such as cilastatin. The addition of a methyl group ... Therefore, imipenem is typically combined with a dehydropeptidase inhibitor such as cilastatin. Imipenem may also lower seizure ...
https://www.merckvetmanual.com/veterinary/pharmacology/antibacterial-agents/use-of-penicillins-in-animals
Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated...Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated...
Kusama M, Yamamoto K, Yamada H, Kotaki H, Sato H, Iga T. Effect of cilastatin on renal handling of vancomycin in rats. J Pharm ...
https://link.springer.com/article/10.1007/s40262-019-00741-9
Imipenem and Cilastatin for InjectionInjectionCisplatin-Induced NephrotoxicityPrimaxinIntra-abdominal infectionsMeropenemEfficacySodium500mgAntibioticRenalMonotherapyIntravenouslySupplierSevereInfectionDrugsPatientsRelebactamDehydropeptidaseRECARBRIOReported with imipenemCarbapenemsInfectionsLinezolidBacterial1985CephalosporinsInhibitsSeizuresIntravenousGanciclovirDoseBeta-lactamsAdverse effectsSymptomsClinicallyUrinary
Imipenem and Cilastatin for Injection2
  • 9% w v Triamcinolone Acetonide Inj 10mg ml, 40mg ml BP USP Cefoperazone and sulbactam for Inj 1 gm Cefoperazone and sulbactam for Inj 2 gm Methylprednisolone Sodium Succinate for Inj USP 500mg Piperacillin and Tazobactam for Injectoin Imipenem and Cilastatin For Injection USP 1gm IMICIL Ceftriaxone Sodium for. (jewishledger.com)
  • This study compared tigecycline with a current empiric combination treatment, Primaxin (imipenem and cilastatin for injection) for intra-abdominal infections. (drugtopics.com)
Injection18
  • Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections. (medlineplus.gov)
  • Antibiotics such as imipenem and cilastatin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
  • Your doctor will tell you how long to use imipenem and cilastatin injection. (medlineplus.gov)
  • You may receive imipenem and cilastatin injection in a hospital, or you may administer the medication at home. (medlineplus.gov)
  • If you are using imipenem and cilastatin injection at home, use it at around the same times every day. (medlineplus.gov)
  • Use imipenem and cilastatin injection exactly as directed. (medlineplus.gov)
  • If you will be using imipenem and cilastatin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • Ask your healthcare provider what to do if you have any problems injecting imipenem and cilastatin injection. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with imipenem and cilastatin injection. (medlineplus.gov)
  • Use imipenem and cilastatin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • If you stop using imipenem and cilastatin injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • Imipenem and cilastatin injection is also sometimes used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cells. (medlineplus.gov)
  • or any of the ingredients in imipenem and cilastatin injection. (medlineplus.gov)
  • Find the Best Pharma PCD Franchise Company for Imipenem 500mg Cilastatin 500 mg Injection to start your own Franchise Business. (rednirusmart.com)
  • We are offering the best Franchise Companies that are dealing in Pharma PCD Franchise for Imipenem 500mg Cilastatin 500 mg Injection for Manufacturers Suppliers in India. (rednirusmart.com)
  • The study aimed to investigate the factors affecting the stability of imipenem and cilastatin sodium for injection (IMI/CIL) to improve the quality and stability in IMI/CIL preparation. (thieme-connect.com)
  • Recarbrio is a three-drug combination injection containing imipenem-cilastatin, a previously FDA-approved antibiotic, and relebactam, a new beta-lactamase inhibitor. (infantrisk.com)
Cisplatin-Induced Nephrotoxicity2
  • Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. (nih.gov)
  • Gómez-Gómez, M. M.: Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity. (hu-berlin.de)
Primaxin1
Intra-abdominal infections1
  • The U.S. Food and Drug Administration has approved Recarbrio (imipenem, cilastatin and relebactam), an antibacterial drug product to treat adults with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). (infantrisk.com)
Meropenem8
  • Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation. (druglib.com)
  • Imipenem/cilastatin and meropenem are carbapenem antibiotics that are infused intravenously (IV) over 30 to 45 min. (druglib.com)
  • We evaluated probability of target attainment and cumulative probability of target attainment of 30-min and 3-h infusions for imipenem/cilastatin and meropenem. (druglib.com)
  • Eighteen healthy adults in a randomized, 4-phase, crossover study received 1000 mg of imipenem/cilastatin or meropenem as a single-dose IV over 30 min or 3 h. (druglib.com)
  • Three-hour infusions of imipenem/cilastatin and meropenem improved the cumulative probability of target attainment for a variety of populations of microorganisms compared to 30-min infusions. (druglib.com)
  • Prolonged infusions have the potential to optimize efficacy of imipenem/cilastatin and meropenem. (druglib.com)
  • In severe infection, piperacillin and tazobactam, imipenem and cilastatin, or meropenem may be used. (roadlesstraveledstore.com)
  • Those with risk factors for Pseudomonas should be treated with a beta-lactam antibiotic (piperacillin/tazobactam, imipenem/cilastatin, meropenem, doripenem, or cefepime), plus an aminoglycoside and azithromycin or an antipseudomonal fluoroquinolone (levofloxacin or ciprofloxacin). (bvsalud.org)
Efficacy2
  • Rotschafer, J. C. / Imipenem/cilastatin efficacy evaluated . (umn.edu)
  • The determination of efficacy of Recarbrio was supported in part by the findings of the efficacy and safety of imipenem-cilastatin for the treatment of cUTI and cIAI. (infantrisk.com)
Sodium3
  • The results showed that oxygen, water, particle shape, and particle size had significant effects on the stability of IMI/CIL, and free water content is a better predictor of the safety and stability of imipenem and cilastatin sodium than the total water content. (thieme-connect.com)
  • This study led to a better understanding of the degradation mechanism of imipenem and cilastatin sodium, and could provide a reference for the selection and control of IMI/CIL process conditions. (thieme-connect.com)
  • cilastatin sodium. (dovepress.com)
500mg1
  • Pharma PCD Franchise Company for Imipenem 500mg Cilastatin 500 mg Inje. (rednirusmart.com)
Antibiotic1
  • Since the antibiotic, IMIPENEM , is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. (bvsalud.org)
Renal1
  • Dado que el antibiótico, IMIPENEM, es hidrolizado por la deshidropeptidasa-I, que reside en el borde en cepillo del túbulo renal, se administra la cilastatina con imipenem para aumentar su eficacia. (bvsalud.org)
Monotherapy1
  • Overall, in patients with a positive culture, the microbiologic eradication rate was 91.3% for tigecycline as a monotherapy treatment versus 89.9% for imipenem/cilastatin, with a similar safety and tolerability profile in the two groups. (drugtopics.com)
Intravenously1
  • When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours. (medlineplus.gov)
Supplier1
  • Imipenem 500 With Cilastatin 500 MG PCD Pharma Supplier & Manufacturin. (rednirusmart.com)
Severe2
  • Imipenem/cilastatin is usually reserved for severe community-acquired pneumonia in the intensive care setting for patients who develop sepsis. (antiinfectivemeds.com)
  • A randomized trial compared imipenem/cilastatin with the third-generation cephalosporin ceftazidime (both IV) in 60 hospitalized patients with moderate to severe community-acquired pneumonia. (antiinfectivemeds.com)
Infection1
  • Case Commentary: Imipenem/Cilastatin and Fosfomycin for Refractory Methicillin-Resistant Staphylococcus aureus Infection: a Novel Combination Therapy. (bvsalud.org)
Drugs1
  • In this fact sheet, MSF looks at accessibility of five key drugs: bedaquiline, delamanid, imipenem/cilastatin, clofazimine and linezolid. (msfaccess.org)
Patients2
  • Streptococcus species [ 3 ], although an in- tion as determined by the Wagner classifi- creasing number of patients have been en- cation. (who.int)
  • This section reviews only imipenem/cilastatin because this class is generally used only in a small subset of community-acquired pneumonia patients. (antiinfectivemeds.com)
Relebactam5
  • Administer RECARBRIO 1.25 grams (imipenem 500 mg, cilastatin 500 mg, relebactam 250 mg) by intravenous (IV) infusion over 30 minutes every 6 hours in patients 18 years of age and older with creatinine clearance (CLcr) 90 mL/min or greater. (nih.gov)
  • RECARBRIO 1.25 grams for injection is supplied as sterile powder for constitution in a single-dose vial containing imipenem 500 mg (anhydrate equivalent), cilastatin 500 mg (free acid equivalent), and relebactam 250 mg (anhydrate equivalent). (nih.gov)
  • One was a priority review for the combination of relebactam, the company's investigational beta-lactamase inhibitor, with MK-7655A, IMI/REL (imipenem/cilastatin), for the treatment of complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) caused by certain susceptible gram-negative bacteria. (pharmatimes.com)
  • Recarbrio is a three-drug combination product containing imipenem, cilastatin, which belongs to a group of drugs called renal dehydropeptidase inhibitors, and relebactam, a new beta-lactamase inhibitor. (rxwiki.com)
  • Cilastatin and relebactam help imipenem work more effectively by preventing the breakdown of the antibiotic. (rxwiki.com)
Dehydropeptidase8
  • Cilastatin is in a class of medications called dehydropeptidase inhibitors. (medlineplus.gov)
  • Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. (adooq.com)
  • Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin (sye" la stat' in), a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. (nih.gov)
  • Pharmacology - This fixed combination of a carbapenem antibiotic (imipenem) and an inhibitor (cilastatin) of dehydropeptidase I (DHP I) has a very broad spectrum of activity. (elephantcare.org)
  • Comparative clinical trial of imipenem-cilastatin (N-formimidoyl-thienamycin-dehydropeptidase inhibitor) and cefazolin. (nih.gov)
  • Cilastatin prevents renal metabolism of imipenem by competitive inhibition of dehydropeptidase along the brush border of the renal tubules. (medscape.com)
  • Since the antibiotic, IMIPENEM , is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. (bvsalud.org)
  • Cilastatin is a chemical substance which inhibits dehydropeptidase (DHP1), a human enzyme that degrades Imipenem. (toku-e.com)
RECARBRIO1
  • Seizures and Central Nervous System Adverse Reactions: CNS adverse reactions such as seizures have been reported with imipenem/cilastatin, a component of RECARBRIO. (nih.gov)
Reported with imipenem1
  • Several instances of cholestatic jaundice arising during or shortly after therapy have been reported with imipenem-cilastatin and other carbapenems. (nih.gov)
Carbapenems1
  • Imipenem-cilastatin, like other carbapenems, binds to bacterial penicillin binding proteins and interferes with bacterial cell wall integrity and synthesis. (nih.gov)
Infections3
  • Imipenem-cilastatin is indicated for the treatment of severe or complicated skin, tissue, joint, respiratory tract, intraabdominal, urinary tract and urogenital infections as well as meningitis, endocarditis and sepsis due to susceptible organisms. (nih.gov)
  • Therapeutic effects of imipenem-cilastatin on experimental intrauterine infections in rats. (nih.gov)
  • Case reports document the successful use of inhaled imipenem/cilastatin in adult cystic fibrosis and non- cystic fibrosis patients with non- M. abscessus pulmonary infections. (nih.gov)
Linezolid1
  • However, titers of antibody in their s and penicillin g cefepime gatifloxacin piperacillin cefotaxime imipenem-cilastatin quinupristin-cefotetan levofloxacin dalfopristin cefoxitin linezolid trimethoprim-ceftazidime sulfamethoxazole antihypertensives diazoxide methyldopa nitroprusside antiarrhythmic agents should probably be higher than mg/dl, have an abnormal number of moles or freckles. (aaan.org)
Bacterial1
  • Imipenem/cilastatin combination inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). (medscape.com)
19851
  • Imipenem/cilastatin was approved for use in the United States in 1985. (nih.gov)
Cephalosporins1
  • Safety and tolerance for imipenem-cilastatin was similar to that of these two cephalosporins. (nih.gov)
Inhibits1
  • Cilastatin inhibits the metabolism of imipenem by DHP 1 on the brush borders of renal tubular cells. (elephantcare.org)
Seizures1
  • Imipenem-cilastatin: Generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin. (pediatriconcall.com)
Intravenous1
  • Intravenous imipenem/cilastatin is among the preferred antibiotics for treatment of M. abscessus, however, its use may result in systemic toxicities including hepatic injury and gastrointestinal effects. (nih.gov)
Ganciclovir1
Dose1
  • Our patient's imipenem-cilastatin dose had been increased 24 hours prior to his violent visual and auditory hallucinations because his renal function had improved. (medscape.com)
Beta-lactams1
  • There were more transient liver function test changes in the imipenem-cilastatin group, but the frequency was similar to that for beta-lactams in general. (nih.gov)
Adverse effects1
  • This case report bridges a void in the medical literature with regards to the psychiatric adverse effects of imipenem-cilastatin. (medscape.com)
Symptoms1
  • Although the carbapenem imipenem cilastatin has similar symptoms months later. (umaine.edu)
Clinically1
  • Parenterally administered imipenem/cilastatin has been associated with transient, mild serum aminotransferase elevations, but it is a rare cause of clinically apparent liver disease with jaundice. (nih.gov)
Urinary1
  • A 64-year-old Hispanic man in septic shock due to urinary tract infection was initiated on imipenem-cilastatin and mechanically ventilated, following admission to hospital. (medscape.com)
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