A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.
The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.
A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is at tyrosine and phenylalanine residues. EC 3.4.22.3.
Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.
A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.
A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.
A reagent used for the determination of iron.
An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.
Services providing pharmaceutic and therapeutic drug information and consultation.
A plant genus of the family Caricaceae, order Violales, subclass Dilleniidae, class Magnoliopsida. It is the source of edible fruit and PAPAIN.
Compounds containing the -SH radical.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.
Deciduous plant rich in volatile oil (OILS, VOLATILE). It is used as a flavoring agent and has many other uses both internally and topically.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Stress wherein emotional factors predominate.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Any substances taken in by the body that provide nourishment.
Tumors or cancer of the STOMACH.
A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.
Infections by nematodes, general or unspecified.
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
A genus of nematode worms comprising the whipworms.

Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (1/37)

Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells.  (+info)

Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. (2/37)

This single-blind randomised clinical trial compared osteopathic manipulative treatment with chemonucleolysis (used as a control of known efficacy) for symptomatic lumbar disc herniation. Forty patients with sciatica due to this diagnosis (confirmed by imaging) were treated either by chemonucleolysis or manipulation. Outcomes (leg pain, back pain and self-reported disability) were measured at 2 weeks, 6 weeks and 12 months. The mean values for all outcomes improved in both groups. By 12 months, there was no statistically significant difference in outcome between the treatments, but manipulation produced a statistically significant greater improvement for back pain and disability in the first few weeks. A similar number from both groups required additional orthopaedic intervention; there were no serious complications. Crude cost analysis suggested an overall financial advantage from manipulation. Because osteopathic manipulation produced a 12-month outcome that was equivalent to chemonucleolysis, it can be considered as an option for the treatment of symptomatic lumbar disc herniation, at least in the absence of clear indications for surgery. Further study into the value of manipulation at a more acute stage is warranted.  (+info)

Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental study. (3/37)

Although chemonucleolysis with chymopapain is a long-established treatment for lumbar intervertebral disc herniation, serious complications have been reported. Accordingly, alternative substances for chemonucleolysis have been sought. The main beneficial effect of chemonucleolysis derives from the decrease in intradiscal pressure. Several previous studies have investigated the relationship between physiological saline injection and disc mechanics in cadaveric specimens [2, 5, 16]. However, no previous study has assessed the intradiscal pressure after intradiscal injection of "hypertonic saline" in living animals. The present study compared the changes in intradiscal pressure after intradiscal injection of hypertonic saline with those after chymopapain injection. The lumbar intervertebral discs of 26 living rabbits were examined: 10% hypertonic saline was injected in ten rabbits, and chymopapain (10 pikokatal units) was injected intradiscally in another ten, with the remaining six being used as controls. The intradiscal pressure was measured at 1, 4, and 12 weeks after injection. The intradiscal pressure of the hypertonic saline-injected group at 4 weeks was significantly lower than that of the control group, but by 12 weeks it had recovered. On the other hand, that of the chymopapain-injected group remained significantly lower than that of the control group at 12 weeks. The results of this study found that hypertonic saline injected into the intervertebral discs temporarily decreased the intradiscal pressure.  (+info)

Chemonucleolysis: the state of the art. (4/37)

This review presents the history of chemonucleolysis, the techniques, indications, contraindications, and complications. Presenting an historical overview and comparison of success rates with surgical discectomy may provide a fresh understanding of the controversy surrounding chemonucleolysis and establish its efficacy in relation to more invasive treatments. A review of the literature from 1973 through 1998 for chemonucleolysis, open discectomy, and microdiscectomy provided published success rates for these procedures, and a mean rate with standard deviation was determined. In the experience and opinion of the authors, chemonucleolysis remains a viable alternative for patients who have exhausted all conservative means of treatment. Proper patient selection leads to success rates comparable to open discectomy and microdiscectomy.  (+info)

Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water. (5/37)

BACKGROUND: This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI) of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. RESULTS: The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. CONCLUSION: The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn.H2O.Sn) of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.  (+info)

The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. (6/37)

OBJECTIVE: The purpose of this work was to test the effect of inhibition of bone remodeling, through the use of the bisphosphonate, zoledronic acid, on cartilage matrix damage in an animal model of cartilage matrix damage. DESIGN: New Zealand white rabbits were divided into four groups for treatment purposes: (1) untreated controls; (2) injected into one knee joint with the cartilage matrix degradation enzyme, chymopapain; (3) injected into one knee joint with chymopapain and also given subcutaneous injections of the bisphosphonate, zoledronic acid, three times per week until sacrifice at either day 28 or 56 post-chymopapain-injection; (4) received only the zoledronic acid injections. At sacrifice, the knee joints were examined grossly and histologically, and biochemically for proteoglycan content. Urine samples were analysed, at intervals, for levels of collagen cross-links which are biochemical markers of cartilage and bone. RESULTS: Animals receiving both intraarticular chymopapain injections and subcutaneous zoledronic acid injections displayed a significantly lower degree of grossly and histologically detectable cartilage degeneration on the tibial articular surfaces (the articular surface displaying the greatest degree of degeneration) than did animals only receiving the chymopapain injections. In addition, urinary levels of collagen cross-links for bone and cartilage were significantly higher in those animals only receiving chymopapain injections. CONCLUSION: The bone resorption observed after chymopapain injection into the rabbit knee joint can be inhibited through the use of the bisphosphonate, zoledronic acid. Furthermore, zoledronic acid does not increase the level of cartilage degeneration and appears to provide some level of chondroprotection in this model.  (+info)

Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. (7/37)

OBJECTIVE: To determine if oral glucosamine (GlcN) improves joint biology after acute damage by a protease. METHODS: The effect of 8 weeks of dietary GlcN (20 or 100 mg/kg/day) on knee joint cartilage was evaluated in 2.2-kg male NZW rabbits with and without damage introduced by intraarticular injection of chymopapain (CP). Cartilage was evaluated histologically and scored according to the Mankin scale. Analyses of total hydroxyproline and glycosaminoglycan (GAG) contents and reverse transcription-polymerase chain reaction (RT-PCR) analysis of selected genes were performed. RESULTS: After 8 weeks, there was no effect of GlcN on the GAG content of normal cartilage. Both levels of GlcN treatment significantly increased the sulfated GAG content in the cartilage of the medial femoral condyle in damaged and contralateral knees, but did not change the collagen content. In CP-injected knees, there was still some loss of surface proteoglycan (PG) that was not completely corrected by dietary GlcN. Even after 8 weeks, levels of messenger RNA (mRNA) detected by RT-PCR showed changes indicative of damage and repair, such as elevated type II collagen mRNA, and these levels were not influenced by GlcN treatment. Meniscal GAG content was increased in the contralateral knee of rabbits receiving high-dose GlcN, but was decreased in those receiving no GlcN or low-dose GlcN. Neither diet nor treatment affected the meniscal collagen content. CONCLUSION: These results suggest that oral GlcN treatment might be useful in a situation where GlcN is limiting, such as where there is a rapid replacement of cartilage PG.  (+info)

Chemonucleolysis. (8/37)

A prospective study of 480 patients who underwent enzymatic dissolution of the nucleus pulposus with chymopapain is reported. Seventy per cent of patients with the clincial criteria for a disc herniation had a favourable response to chemonucleolysis. The commonest cause of failure was persistent back pain. In patients with sequestered discs or lateral recess stenosis surgical intervention was not made more difficult by chemonucleolysis. Those with a previous operation, spinal stenosis or psychogenic components to the disability had very poor results. Complications were few and easily managed.  (+info)

Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and significantly lower than those of papain or ficin. The environment of the ...
Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
ment of back pain; it consists of a percutaneous intradiskal ment of the disk, we performed a concomitant injection of intra- injection that dissolves the nucleus pulposus and lowers in- articular steroids in the adjacent facet joints in all patients.9 tradiskal pressure. Several years ago, the most widely used sub- Procedures were performed with local anesthetic, under surgical stance for this was chymopapain, which had an efficacy of conditions and controlled digital fluoroscopy. A diskography was close to 80% in lumbar disk herniations and close to 85% in performed before RGE nucleolysis. The dose of RGE injected into the cervical disk hernias1-3 but was withdrawn from the market cervical disk was 0.2- 0.3 mL. Intradiskal injection of 1-2 mg of gen- due, in part, to anaphylactic reactions to this enzyme.4 After tamicin was systematically performed in all the cases at the end of the this, the search for a new drug that could have the same effi- procedure to prevent infection. At least 1 facet ...
Proteolytic enzyme compositions and processes for digesting connective tissue are provided. The enzyme compositions include collagenase, which is essentially free of toxins and non-collagen specific components, and chymopapain, which is essentially free of toxins. The enzyme compositions are used for dissociating microvessel cells from connective tissue. Recovered microvessel cells are incorporated into artificial vessel grafts. The composition preferrably contains collagenase having an activity of about 43 nkat/ml to about 51 nkat/ml and chymopapin having an activity of about 0.22 nkat/ml to about 0.44 nkat/ml.
We carry a limited range of rongeurs and spinal instruments following requests from veterinary surgeons, however our supplier carries a full range of instruments within this field so if you need something we dont list just ask and we give you a quote. Similarly if you have an idea for a new instrument or modification of an existing instrument we would be very keen to help make your idea reality. ...
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Parasite international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology
Salutary effects of carica papaya leaf extract in dengue fever patients- a pilot study... Salutary effects of carica papaya leaf extract in dengue fever patients- a pilot study.. Thrombocytosis and anti-inflammatory properties, and toxicological evaluation of carica papaya mature leaf concentrate in a murine model... A study of haemato-stimulatory effects of graded dose of aqueous carica papaya seed extract in wistar rats... Dengue fever treatment with carica papaya leaves extracts... Carica papaya leaves juice significantly accelerates the rate of increase in platelet count among patients with dengue fever and dengue haemorrhagic fever... The effect of carica papaya l. Leaves extract capsules on platelets count and hematocrit level in dengue fever patient... Evaluation of platelet augmentation activity of carica papaya leaf aqueous extract in rats.. ...
Define Carica papaya. Carica papaya synonyms, Carica papaya pronunciation, Carica papaya translation, English dictionary definition of Carica papaya. Noun 1. Carica papaya - tropical American shrub or small tree having huge deeply palmately cleft leaves and large oblong yellow fruit melon tree, papaia,...
Papain is also known as papaya proteinase-I which is an enzyme present in papaya. Papain is an important digestive enzyme which breakdown tough protein fibers. Papain is very stable also at very elevated temperatures. Papain latex is a rich source of cysteine endopeptidases including chymopapain, caricain and glycyl endopeptidase. Papain is traditionally used as a meat tenderizer and also used in skin burns, skin ulcers, wounds etc. Some of the common uses of papain are it boosts digestion, treats skin and wound, resistant to fungus, supports immune system and source of antioxidant etc. As papain is source of antioxidant, it is commonly used in food preservation to reduce bacterial infestations and spoilage of food due to oxidation.. Market Segmentation: Papain. The Papain market is segmented on the basis of its applications in different industries like food industry, cosmetic industry, pharmaceutical industry and chemical industry etc. Papain is used for food industry for food processing, as a ...
Papaya is likely safe when consumed in food amounts. Fermented papaya is possibly safe when used medicinally for up to three months. Use with caution in patients with bleeding disorders or those taking agents that may increase the risk of bleeding, in patients with diabetes or hypoglycemia or those taking agents that affect blood sugar, and in patients with autoimmune disorders or those using agents that affect the immune system. Use papaya seed extract and the papaya enzyme papain with caution. Use cautiously with vitamin A or retinoids, beta-carotene or carotene-containing foods, iron or iron-rich foods, sodium, potassium supplements, or agents that alter potassium levels. Avoid in patients with a known allergy or hypersensitivity to papaya, its components (including papaya juice, papaya flower pollen, papain, and chymopapain), members of the Caricaceae family, or latex. Cross sensitivity between kiwi and papaya, as well as papain, has been reported. Severe life-threatening allergic reactions ...
In the early 1960s, Lyman Smith injected chymopapain into a herniated lumbar disc using what was later to be termed the safe zone by Kambin and thus began the era of minimally invasive spine surgery.29 The first meeting of the International Society for Minimal Intervention of Spine Surgery in April 1990 further defined the term minimally invasive spine surgery against the back drop of the additional advances that had been made in endoscopic spine surgery techniques and approaches.. Endoscopic spinal surgery clinical outcomes have been studied for the past 25 years. These outcomes have included prospective randomized clinical trials evaluating the effectiveness of endoscopic techniques versus open posterior microdiscectomy techniques in the treatment of primary and revision lumbar disc herniations.1,30-34 These trials have revealed equivalency in outcomes amongst the two treatment groups. Recent non-randomized lumbar studies include a single surgeon evaluation of 400 patients using the ...
Introduction: Over centuries, Carica papaya (papaya) has been used as a nutritious and medicinal plant. In view of its medicinal uses, our group focused on aqueous leaves extract of papaya and tried to determine its antimicrobial (using bacterial strains i.e. gram positive and gram negative ones) and anti-inflammatory (virally infected human whole blood) activities. The protein content of the plant and its secondary metabolites were also analysed qualitatively.Methods: The protein content from aqueous leaves extract of C. papaya was quantified using Nanodrop method. ELISA studies were conducted in order to determine the antibody production against ovalbumin (OVA) using papaya aqueous leaves extract. Also, its antigen specific proliferation in virally infected human whole blood samples was determined through MTT assay. In addition, antimicrobial studies (using gram positive and gram negative strains) and cytotoxicity were also studied.Results: The aqueous leaves extract of papaya showed enhancement in
Papaya Tainung (Carica papaya), a red commercial variety, is deliciously sweet & produces abundant fruits that weigh from 3 to 5 pounds. Excellent for pots.
Hassler, M. 2019. Carica papaya. World Plants: Synonymic Checklists of the Vascular Plants of the World (2019). In: Roskov Y., Abucay L., Orrell T., Nicolson D., Bailly N., Kirk P., Bourgoin T., DeWalt R.E., Decock W., De Wever A., Nieukerken E. van, Zarucchi, J., Penev L., eds. 2019. Species 2000 & ITIS Catalogue of Life. Published on the internet. Accessed: 2019 Aug. 30 ...
Buy or license direct from the photographer this stunning image of : Toucan (Ramphastidae), In A Carica Papaya Eating Its Juicy Fruit
Free Essays from Bartleby | Effect of Carica papaya seed extract on the cell wall of A. flavus under transmission electron microscope: In this experiment,...
Due to the coronavirus outbreak worldwide, global demand for some personal protective equipment (PPE) is exceeding supply. In addition, manufacturing of PPE and many other wound care and infection prevention products have been impacted by global response to coronavirus. While you may see product availability reduction in the near-term, please be assured Medline continues to work to diversify production and provide your supply needs. As always, please reach out to your Medline sales representative with any specific questions or follow up. ...
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Superior quality bulk Papaya Leaf available from Starwest - offering the finest chinese, craft, culinary, and therapeutic herbs since 1975.
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The charming vintage style of this pillow will transport you straight to the tropics. Its retro vibe is perfect for adding a playful touch to most any room. Mix and match it with a collection of other pillows in the same color palette for maximum impact. Carica Papaya print. 50/50 Down/Poly insert included.
La papaya o la papaya (Carica papaya) es una fruta tropical, que se ha asociado constantemente a las propiedades medicinales numerosas
The benefits of papaya are both internal and external because in addition to improving your digestion and strengthening your immune system, papaya also helps to prevent cellular damage ...
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The normal usage of papaya seeds is 1 tbsp. of them. This dosage is enough to get rid of the all toxins in the liver. Researches proved that these seeds prevent cirrhosis. Consume 5 papaya seeds, two times on a daily basis for 30 days continuously.. Or, you can grind them, crush them if the seeds are fresh in a mortar, and then add them to a refreshing lime juice. Drink this treatment twice per day for 30 days.. Promote Digestive Wellness. Papaya is ideal for digestion, and papaya seeds are rich in potent anti-parasite and antibacterial properties which remove the hazardous microorganisms in the intestinal tract. Moreover, papaya provides powerful anti-pathogenic properties that prove you need to eat 1 tbsp. of these seeds to prevent food poisoning and to eliminate bacteria that provoke digestion problems.. Reduce Swelling in Inflammatory Diseases. Papaya consists of 2 amazing enzymes, papain and chymopapain, which due to their powerful anti-inflammatory properties, they soothe swelling in case ...
Papaya leaf juice aids in the breakdown and metabolism of protein, exhibits anti-ulcer activity and helps to relieve indigestion. Papaya leaf contains the powerful proteolytic enzymes, papain and chymopapain, which digest proteins, small peptides, amides and esters. Their activity extends to carbohydrate and fat, and they are said to be more effective than naturally- occurring proteases like pepsin and trypsin. Since stomach ailments are often the direct result of indigestion, papaya leaf juice may help prevent and remedy these by increasing digestive processes, as the digestive properties of papain are well established ...
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Owoyele, Bamidele V., Adebukola, Olubori M., Funmilayo, Adeoye A, Soladoye, Aydoele O. 2008. Anti-inflammatory activities of ethanolic extract of Carica papaya Leaves. Inflammopharmacology 16 (2008) 168-173.. Papaya 2002. ,URL: http://www.herbs2000.com/herbs/herbs_papaya.htm, Accessed 28 March 2011. Papaya 2011. ,URL: http://www.hort.purdue.edu/newcrop/morton/papaya_ars.html#Origin%20and%20D istribution, Accessed 28 March 2011. Papayas. ,URL: http://www.innvista.com/health/foods/fruits/papayas.htm,. Accessed March 23rd 2011. Papaya Nutritional Information and Facts 2005. ,URL: http://www.juicing-for- health.com/papaya.html, Accessed 28 March 2011.. Phylum Magnoliophyta. ,URL: http://people.uvawise.edu/swvaflora/Magnoliophyta.html,. Accessed March 12th 2011.. ...
Papaya orchard. Fruit growing on papaya trees, Carica papaya, in an orchard. Papaya is also known as the common pawpaw. The tree produces large, spherical fruit which may be eaten at breakfast, in salads or for dessert. Papaya leaves can be wrapped around meat when it is cooked. While it is known that papaya trees are native to the New World, their exact origin is uncertain. Photographed in Hawaii, USA. - Stock Image E768/0165
Traditional plant treatment for diabetes has shown a surging interest in the last few decades. Therefore, the purpose of this study was to assess the hypoglycemic effect of the aqueous extract of C. papaya leaves in diabetic rats. Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans. Diabetes was induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ). The aqueous extract of C. papaya was administered in three different doses (0.75, 1.5 and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks. The aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (p|0.05) in diabetic rats. It also decreased cholesterol, triacylglycerol and amino-transferases blood levels. Low plasma insulin levels did not change after treatment in diabetic rats, but they significantly increased in non-diabetic animals. Pancreatic islet cells were
Carica papaya L. is a scrub like a tree with the upright stalk and round. The top can be branch or not, side of that like a spons and hollow, in the outside a lot of leaf scars. The height of the tree around 2,5-10 m, petiole hollow round, the length around 2,5-10 m, round leaf or oval, bone of the leaves are finger shape, serrated edge, sharing such as finger, pointed tip with diameter around 25-75 cm, the top is green, the bottom is light green, slippery, and gloomy, each of three circle stalk trere are 8 leaves. The flowers almost always unisexual or dioecious, but mostly with several hermaphrodite flower in the staminate bouquet. The staminate in the bunches that same with tassel and long stalk, very small petals, the crown like a cream trumpet, with five edge, and long tube, slim, spin edge in the bud, anthers short stemmed, and the pistillate mostly stand-alone, the crown leaves loose and almost loose, cream, ovary tipped one, anthers are five. This plant can be found almost in the whole ...
Starch isolated from carica papaya was modified by treatment with sodium monochloroacetate.. Proximate analyses revealed that moisture, ash, fat, protein and carbohydrate increased after carboxymethylation. But, percentage fibre content reduced from 11.46% in native starch to 9.69% in carboxymethyl starch derivative. The carboxymethylation reaction was confirmed by the presence of new intense bands at 1600 and 1419 cm-1 associated with the carboxyl and carboxymethyl substituents of the etherifying agent. The starch exhibited higher water and oil absorption capacities following modification and least gelation concentration reduced in carboxymethylated starch but increased in native starch. The blue value of starch-iodine colour complex, and turbidity stability decreased and improved respectively after carboxymethylation. Carboxymethylated starch showed a significantly lower pasting temperature, peak viscosity, trough viscosity and setback viscosity as compared to native starch. Differential ...
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This is a clinical study looking at the effectiveness and safety of a new device call The Paradise System to use for renal denervation in patients who have mild to resistant hypertension. The study is divided into two groups, those on one to two anti hypertensive medications and those on three or more. For those only taking one or two medications, they will stop their current blood pressure medication while monitoring their blood pressure. Those who are taking 3 or more blood pressure medications will stop their current medication regime and be given one of two combination medications while monitoring their blood pressure. In each of the groups have the patients, if and when they continue to meet study inclusion criteria, will be randomized to undergo a renal denervation procedure using the new system vs no procedure. Their assignment will not be made known to them. All groups will be follow up to 3 years but for patients who did not initially have the procedure will be allowed to do so after ...
The papaya tree is one of the most distinctive plants on earth. It is generally 4 to 5 meters tall and unbranched, but old plants may be 10 meters tall. The trunk looks a little like an upside-down, gray carrot. This plant has huge leaves with very long petioles and are clustered near the top of the tree, because the lower ones are shed, leaving large, circular scars on the bark. The stem is soft and weak because it has very flimsy wood (secondary xylem) and a hollow center. Once a plant starts to produce, there is a continuous supply of fruits. All one has to do is to climbing to harvest the lowermost papaya fruit.. The ripe fruit has a yellow and green skin, often with tints of red and orange, and a sweet, semi-firm, yellow-orange pulp. Within the central cavity of the fruit are hundreds of dark seeds that almost appear bluish when the fruit is cut open; they are about the size of small peas and are attached to the pulp. Papaya fruit is most commonly eaten fresh for dessert or made into a ...
The large oval fruits of this "Melon tree" are attached in clusters just under its umbrella of snowflake shaped leaves. Tropical. Makes a very handsome indoor ornamental tree if you provide sufficient warmth and bright light. With ideal conditions will bear fruit in 1 year. Self pollinating. Mature hgt. 18'-25' Growing Instructions & Tips: Plant at 1/2" depth using well draining soil mixture. Keep warm and damp - not wet. Requires bright light. Fertilize every two weeks.
Papaya - Get complete information on papaya fruit, green papaya, papaya tree, papaya plants, fresh papaya uses, health benefits of papaya fruits and papaya suppliers, green papaya exporters from India.
Papaya plants (Carica papaya), commonly referred to as trees, are actually very large herbaceous perennials, usually with a short life span (but capable of living up to 20 years). Papayas produce large fruit with very sweet, yellow to red-orange-colored flesh. They are not difficult to grow when given a site with ...
We offer discount medical surgical supplies and instruments in the Orthopedic Rongeurs category, such as the Smith Peterson Laminectomy Rongeur 9 1/2 40-4110
Agenda Presentasi Pendahuluan Aspek Bioteknologi Struktur Papain Teori mengenai Papain Isolasi dan Karakterisasi Papain dari Pepaya (Carica papaya)
What is Carica? It is is a type of papaya fruit, often called mountain papaya and it contains many beneficial vitamins. What are interesting and unique from
Carica sem zato ker... Nosim ljubezen do sebe. Moje tri lasnosti, ki jih najbolj cenim pri sebi so; sočutnost, ljubezen in hvaležnost. Pri drugih najbolj cenim;
2 Free Carica 3D Models for download, available in 3DS, MAX, OBJ, C4D, MAYA, BLENDER, FBX, SKP with lowpoly, rigged, animation, vr, game.
Carica sem, ker sem pri 50. letih zaprla uspešno podjetje - in začela na novo. Prej več kot 20 let v računovodstvu, zdaj vaša mentorica in coachinja za vaš
(KudoZ) Russian to Italian translation of переводная головка: corona di carica [orologi - Mechanics / Mech Engineering (Tech/Engineering)].
One Punch Man Original Webcomic (ONE)2 pagina 1 (Carica immagini: 10), One Punch Man Original Webcomic (ONE) Manga italiano, read One Punch Man Original Webcomic (ONE)76: Stallo e crescita on-line
One Punch Man Original Webcomic (ONE)4 pagina 1 (Carica immagini: 6), One Punch Man Original Webcomic (ONE) Manga italiano, read One Punch Man Original Webcomic (ONE)76: Stallo e crescita on-line
What is benefits of papaya for health? - There are 2 main papaya varieties: Mexican, which may weigh the maximum amount as ten pounds, and also the a lot of…
The juicy yellow papaya is fully loaded with nutrients and has a rich source of dietary fiber. Here we have also listed a few side effects of papaya. ReadOn
Anggotaa DPR RI dari Fraksi Partai Kebangkitan Bangsa (PKB) Drs. H. Taufiq R. Abdullah mendesak kepada pemerintah agar bersungguh-sungguh memberikan dukungan untuk pengembangan hasil pertanian khas Ba
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Todays article talks about the many beneficial properties you can get from eating just a slice of papaya every day. Dont miss it!
Zucker S, Buttle DJ, Nicklin MJ, Barrett AJ (April 1985). "The proteolytic activities of chymopapain, papain, and papaya ... Robinson GW (August 1975). "Isolation and characterization of papaya peptidase A from commercial chymopapain". Biochemistry. 14 ... chymopapain S, Pp) is an enzyme. This enzyme catalyses the following chemical reaction Hydrolysis of proteins with broad ... multiple forms of chymopapain A and papaya proteinase omega". The Biochemical Journal. 228 (2): 525-7. doi:10.1042/bj2280525. ...
Polgár L (April 1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochimica et ... Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya ... proteinase 4, PPIV, chymopapain M) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage: ...
The procedure was first reported by Lyman W. Smith in 1964, and used chymopapain. Discolysis using chymopapain is no longer ...
"Transforaminal Posterolateral Endoscopic Discectomy With or Without the Combination of a Low-Dose Chymopapain: A Prospective ...
Patients with allergies to papain, chymopapain, other papaya extracts or the pineapple enzyme bromelain may also be at risk for ...
Chronovera Chronulac Chymex Chymodiactin chymopapain (INN) chymotrypsin (INN). ...
... and chymopapain. It is one of the most commonly used for differentiating many blood group antigens: For example, it destroys M ...
... chymopapain MeSH D08.811.277.656.300.215.350 - ficain MeSH D08.811.277.656.300.215.585 - papain MeSH D08.811.277.656.300.480 - ...
M09AA01 Hydroquinine M09AA72 Quinine, combinations with psycholeptics M09AB01 Chymopapain M09AB02 Collagenase clostridium ...
... chymopapain, now EC 3.4.22.6 EC 3.4.4.12: ficin, now EC 3.4.22.3 EC 3.4.4.13: thrombin, now EC 3.4.21.5 EC 3.4.4.14: plasmin, ... chymopapain EC 3.4.22.7: asclepain EC 3.4.22.8: clostripain EC 3.4.22.9: yeast proteinase B. Now EC 3.4.21.48, cerevisin EC 3.4 ...
... (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Studying A280 chymopapain is found in the fraction of 750-1000 ml. Once chymopapain has been isolated, it can be crystallized ... Chymopapain's structure was solved by X-ray diffraction techniques. Analysis of this structure showed chymopapain to have 7 ... Chymopapain presents a quaternary structure characterized by the formation of homo dimers, which means that two chymopapain ...
... may refer to one of two enzymes: Chymopapain Caricain This disambiguation page lists articles associated with the ... title Chymopapain S. If an internal link led you here, you may wish to change the link to point directly to the intended ...
Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Studying A280 chymopapain is found in the fraction of 750-1000 ml. Once chymopapain has been isolated, it can be crystallized ... Chymopapains structure was solved by X-ray diffraction techniques. Analysis of this structure showed chymopapain to have 7 ... Chymopapain presents a quaternary structure characterized by the formation of homo dimers, which means that two chymopapain ...
Chymopapain S may refer to one of two enzymes: Chymopapain Caricain This disambiguation page lists articles associated with the ... title Chymopapain S. If an internal link led you here, you may wish to change the link to point directly to the intended ...
Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and ... Uses For chymopapain. Chymopapain is injected directly into a herniated ("slipped) disk in the spine to dissolve part of the ... Proper Use of chymopapain. Dosing. The dose of chymopapain will be different for different patients. Follow your doctors ... Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain ...
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. ...
65 Pages Report] Check for Discount on chymopapain from papaya latex Global Market and Forecast Research report by ChemReport. ... chymopapain from papaya latex Global Market and Forecast Research Table of Contents Part 1: General Information of chymopapain ... Potential users of chymopapain from papaya latex The main trading companies of chymopapain from papaya latex List of Figures ... 2.2 Construction of Industry Chain of chymopapain from papaya latex Chapter 3: End User of chymopapain from papaya latex List ...
... chymopapain 10,000 units/vial injection) was not withdrawn from sale for reasons of safety or effectiveness. This determination ... Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness. ... This determination will allow FDA to Start Printed Page 3887approve abbreviated new drug applications (ANDAs) for chymopapain ... CHYMODIACTIN (chymopapain 10,000 units/vial injection) is the subject of NDA 18-663. CHYMODIACTIN is indicated for the ...
... Olmarker, K ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Animals, Cartilage, Cheek, Chondroitin Lyases, Chondroitinases and Chondroitin Lyases, Chymopapain, Cricetinae, Mesocricetus, ...
Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many ... Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of ... There can be no question but that the M2H factor for chymopapain was one of highest ever recorded. Because it wasnt released ... Chemonucleolysis with chymopapain (or other enzymes such as collagenase) really werent a bad idea if qualified people were ...
Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and ... Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ...
... unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. ... The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published ... A brush is useful in removing strands of nucleus loosened by chymopapain. ... significantly more nucleus is removed if chymopapain is used in addition to rongeurs. ...
Experts available for chymopapain consulting, expert witness, or analyst services for business, legal, and technical ... Chymopapain Experts. The following experts are available as chymopapain consultants and chymopapain expert witnesses. ORC ... Definition: Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. ...
Current Status of Chymopapain for Herniated Nucleus Pulposus. Javid, Manucher J.; Nordby, Eugene J. ... Current Status of Chymopapain for Herniated Nucleus Pulposus. Javid, Manucher J.; Nordby, Eugene J. ...
Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ...
... chymopapain; collagenase; tyrosinase;thermolysin; and nuclease (RNAase and DNAase).Partially degraded by pepsin and papain ...
Lickables Nutritional Gel Chicken official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.
Drugs: Use of Chymopapain. *Chapter 25. Drugs: Biosimilar Biological Products. *Chapter 26. Drugs: Investigational Drug, ...
Lumbar disk disease is a frequent source of low back pain. Sciatica is defined as neuralgia along the course of the sciatic nerve.
Chymopapain 3.4.22.6. Chymotrypsin 3.4.21.1. α-Chymotrypsin - Insoluble 3.4.21.1. α-Chymotrypsinogen A 3.4.21.1. ...
An example is chymopapain, used for chemonucleolysis. It was initially associated with anaphylaxis in as many as 1.5% of ... Five-year results from chemonucleolysis with chymopapain or collagenase: A prospective randomized study.. Clinical evaluation ...
chymopapain;. chymopapain A;. chymopapain B;. chymopapain S. Class. Hydrolases;. Acting on peptide bonds (peptidases);. ...
Chymopapain: a shot from the past. Pain practice Mitra, R., Wedemeyer, M., Cheng, I. 2008; 8 (4): 331-332 View details for DOI ...
0051] Proteolytic enzymes: Chymopapain, Chymotrypsin, Trypsin, Hyaluronidase. [0052] Antispasmodic: Oxybutynin, Papaverine. ...
Then injections of pain killers, then chymopapain. Then surgery. My doctors did not believe in physical therapy by non- ...
Papaya contains papain and chymopapain. "These enzymes soothe the stomach by breaking down proteins, which promotes a healthy ...
Chymopapain and semipurified collagenase had similar morphologic and mechanical effects. The temporary increases in flexibility ... The largest increase was noted in flexion in discs injected with chymopapain. By 3 months, all lateral bending flexibilities ... or chymopapain. Controls consisted of saline-injected and uninjected discs. The bending and torsional properties of each disc ...
Allicin (Garlic); Beta-Carotene; Chymopapain; L-Cystine; Methionine; Papain; Peroxidase; Pluriamin. Night Queen. Mimosa Pudica ...
Chymopapain (brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a ... 1.Rarely used technique involving injection of chymopapain into the nucleus pulposus of an intervertebral disc as a therapeutic ... medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, ... http://en.wikipedia.org/wiki/Chymopapain. __________________________________________________ __________________. Optum Encoder ...
Chymopapain / administration & dosage, therapeutic use*. Endopeptidases / therapeutic use*. Female. Humans. Intervertebral Disk ...
Other surgical options include chymopapain injections and microendoscopic surgery.. Learn more about Conditions & Diseases ...
  • Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). (wikipedia.org)
  • Plant peptidases such as papain (EC 3.4.22.2), ficin (EC 3.4.22.3), chymopapain (EC 3.4.22.6), asclepain A (EC 3.4.22.7), actinidin (EC 3.4.22.14), glycyl endopeptidase (EC 3.4.22.25), caricain (EC 3.4.22.30), ananain (EC 3.4.22.31), stem bromelain (EC 3.4.22.32 and fruit bromelain (EC 3.4.22.33). (embl.de)
  • Chemonucleolysis with chymopapain (or other enzymes such as collagenase) really weren't a bad idea if qualified people were involved in injecting them. (burtonreport.com)
  • After a respectful period of time chemonucleolysis with chymopapain began to re-emerge in Europe in a lower dose application….where it remains today. (burtonreport.com)
  • Five-year results from chemonucleolysis with chymopapain or collagenase: A prospective randomized study. (thefreedictionary.com)
  • 1.Rarely used technique involving injection of chymopapain into the nucleus pulposus of an intervertebral disc as a therapeutic option for the treatment of a herniated nucleus pulposis (slipped disk). (aapc.com)
  • Chemonucleolysis involved the injection of therapeutic doses of chymopapain into the intervertebral disc space to induce depolymerization of mucoprotein. (cdc.gov)
  • Presence of protein digesting enzymes like papain and chymopapain in papaya reduces inflammations and cures arthritis pain. (selfgrowth.com)
  • The presence of papain and chymopapain in papaya is in part responsible for the anti-inflammatory effects of the fruit. (mercola.com)
  • Another dangerous side effect of chymopapain injection is a severe allergic reaction called anaphylaxis. (drugs.com)
  • Previous chymopapain injection-Increased risk of serious allergic reactions. (drugs.com)
  • As the laboratory staff watched in awe the rabbit's ears began to wilt following the intravenous injection of the enzyme chymopapain. (burtonreport.com)
  • The dogs were killed 2, 4, 12, 26, and 52 weeks following injection with 0.1-0.15 ml of either crude collagenase, semipurified collagenase, or chymopapain. (cdc.gov)
  • This was the result of a chymopapain injection, six months prior). (healingwell.com)
  • Although ablation can be achieved with a laser, chymopapain injection and intradiskal electrotherapies also have been utilized. (aaos.org)
  • It is rich in enzymes like papain and chymopapain, which aids digestion, prevents bloating and other digestive disorders. (themedguru.com)
  • The following information includes only the average doses of chymopapain. (drugs.com)
  • Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. (biochemj.org)
  • Chymopapain (brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). (aapc.com)
  • The chemical constituents of Carica papaya include papain and chymopapain, which are suggested to aid digestion. (ispub.com)
  • Papaya (Carica papaya L.), a popular fruit tree of tropical and subtropical countries of the World, is considered as one of the rich source of vitamins A and C. In addition, it contains enzyme papain and chymopapain, both of which are widely used in the food and drug [ 1 ]. (alliedacademies.org)
  • Chymopapain injections are given only in a hospital, usually in an operating room, by your surgeon. (drugs.com)
  • 1] Chymopapain injections are normally given under local, rather than general, anaesthesia. (aapc.com)
  • Other surgical options include chymopapain injections and microendoscopic surgery. (reference.com)
  • Proteases such as chymopapain and trypsin can be used in some instances to release cells or interrupt antigen-antibody interaction. (neb.com)
  • Chymopapain and semipurified collagenase had similar morphologic and mechanical effects. (cdc.gov)
  • Papain shares allergenic structures with (i) chymopapain and other papaya extracts. (btgplc.com)
  • As well as all the other enzymes in the PLCPs group, chymopapain is a cysteine protease. (wikipedia.org)
  • The environment of the catalytic site of chymopapain A is markedly different from those of other cysteine proteinases studied to date, as evidenced by the pH-dependence of the second-order rate constant (k) for the reaction of the catalytic-site thiol group with 2,2′-dipyridyl disulphide. (biochemj.org)
  • The striking bell-shaped component that is a characteristic feature of the reactions of S-/ImH+ (thiolate/imidazolium) ion-pair components of many cysteine-proteinase catalytic sites with the 2,2′-dipyridyl disulphide univalent cation is not present in the pH-k profile for the chymopapain A reaction. (biochemj.org)
  • Medicinally it has been valued for its enzymes, papain and chymopapain, which help with the digestion of proteins. (emaxhealth.com)
  • A great natural energy drink, containing special protein digesting enzymes papain and chymopapain that aids healthy digestion. (ecochildsplay.com)
  • Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many practitioners learned that this was not as simple as it seemed. (burtonreport.com)
  • Before receiving chymopapain, you should discuss its use, and the possibility of anaphylaxis or other serious side effects, with your doctor. (drugs.com)
  • The latex contains the protein-degrading (proteolytic) and mucolytic enzymes papain and chymopapain. (fijiresort.com)
  • Researchers believe the proteolytic enzymes chymopapain and papain in papaya are responsible for these beneficial effects. (ecobeautyeditor.com)
  • Epitope Class III: Clone 581 recognizes a sialidase / glycoprotease / chymopapain insensitive class III epitope. (beckman.com)
  • It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. (novusbio.com)
  • Chymopapain chemonuclolysis is the least invasive technique to treat lumbar disc herniation and relieve pain from related sciatica. (sciencephoto.com)
  • Chemonucleolysis is a treatment in which an enzyme, chymopapain, is injected directly into a herniated lumbar disc in an effort to dissolve material around the disc, thus reducing pressure and pain. (lifescript.com)
  • The 561 antibody recognizes a class III group epitope, which is resistant to sialidase/glycolyprotease and chymopapain treatment. (biolegend.com)
  • The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. (biochemj.org)
  • Papaya contains several unique protein-digesting enzymes including papain and chymopapain. (vivawoman.net)
  • It's also a source of papain and chymopapain, protein-digesting enzymes which help reduce inflammation. (faithful-to-nature.co.za)
  • [ 2 ] Papaya contains papain , chymopapain, glycyl endopeptidase, and glutamine cyclotransferase - all of which help digest protein. (globalhealingcenter.com)
  • Papain and another enzyme, chymopapain also reduces inflammation, especially in the area of joints. (healthandnutritiontips.net)
  • Two enzymes in papaya - papain and chymopapain - have been found to help relieve inflammation, a major problem for people suffering from diseases like osteoarthritis and rheumatoid arthritis. (hubpages.com)
  • Tell your doctor if you have ever had any unusual or allergic reaction to chymopapain or any other medicines. (drugs.com)
  • The procedure's use is extremely limited, in part because some patients may have a life-threatening allergic reaction to chymopapain. (lifescript.com)
  • Latex (the milky liquid) is a mixture of papain, endopeptidases, and chymopapain (3) . (momjunction.com)
  • Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. (orcexperts.com)
  • Day A, Savage D, Friedman W (1986) Chemonucleolysis versus open discectomy: the case against chymopapain. (springer.com)
  • When this two bonds are broken, the catalytic triad from the chymopapain is available to be used again. (wikipedia.org)
  • Thus the abnormal catalytic-site environment of chymopapain A detected by the reactivity-probe studies, which may have consequences for the acylation step of the catalytic act, does not perturb the conformation of the bound acyl group at the acyl-enzyme-intermediate stage of catalysis. (biochemj.org)
  • A therapeutic concentration (2000 pKat/ml) of chymopapain stopped the microcirculation in the injected area immediately, with numerous microbleedings at the border zone. (lu.se)
  • It is rich in the enzymes papain and chymopapain, which help lower acidity and break down proteins in your stomach. (wikihow.com)
  • The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. (biochemj.org)
  • The preparation of fully active chymopapain free of contaminating proteinases. (genome.jp)
  • We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of chymopapain from papaya latex. (reportsnreports.com)
  • Two spines, each of which consists of seven discs, were used for each of the following procedures: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. (biomedcentral.com)
  • The largest increase was noted in flexion in discs injected with chymopapain. (cdc.gov)
  • Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve. (drugs.com)
  • The sad part of this tale is that the inadvertent deposition of chymopapain into nerve tissue as well as the sub-arachnoid space created some horrendous problems (including stroke, paraplegia, and death) for a significant number of patients. (burtonreport.com)
  • Chymopapain induced severe effects on the cartilage and surrounding tissues. (lu.se)
  • Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
  • Very rarely, use of chymopapain may cause serious side effects, including paralysis of the legs or death. (drugs.com)
  • The dose of chymopapain will be different for different patients. (drugs.com)
  • One prominent Canadian orthopedic chymopapain advocate stated at a medical meeting that all he required was a "few cc's of chymopapain" to take care of all of his spine patients! (burtonreport.com)
  • Unfortunately the use of chymopapain created new problems for patients. (burtonreport.com)
  • Why, he reasoned couldn't chymopapain also dissolve the collagen in a herniated disc? (burtonreport.com)
  • From this basic observation the saga of chemonucleolysis (enzymatic dissolution of disc collagen) with chymopapain (the active ingredient in Adolf's meat tenderizer) was born. (burtonreport.com)
  • The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published but we are not aware of any previous quantitative studies on procedures for removing as much nucleus as possible from the disc. (biomedcentral.com)
  • Chymopapain is an enzyme that has been used successfully in the treatment of herniated nucleus, as alternative [ 7 - 9 ] or as an adjunct [ 10 ] to surgery. (biomedcentral.com)
  • The presence of other medical problems may affect the use of chymopapain. (drugs.com)
  • Therefore, the ability to work in low pH conditions supports the idea that chymopapain can be found in lysosomes. (wikipedia.org)
  • Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of medical devices and techniques even today. (burtonreport.com)
  • Chymopapain is no longer used as a standard method to treat chronic low back pain because of its potential side effects. (wikipedia.org)
  • Microvascular effects of chondroitinase ABC and chymopapain. (lu.se)
  • significantly more nucleus is removed if chymopapain is used in addition to rongeurs. (biomedcentral.com)