Chymopapain: A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.Intervertebral Disc Chemolysis: The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.Ficain: A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is at tyrosine and phenylalanine residues. EC 3.4.22.3.Bromelains: Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.Papain: A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.Cystatins: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.2,2'-Dipyridyl: A reagent used for the determination of iron.Intervertebral Disc Displacement: An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Carica: A plant genus of the family Caricaceae, order Violales, subclass Dilleniidae, class Magnoliopsida. It is the source of edible fruit and PAPAIN.Sulfhydryl Compounds: Compounds containing the -SH radical.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Morphogenetic Protein Receptors, Type I: A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.Patient Education HandoutAsimina: A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain asitrocin, asitrilobins, and other tetrahydrofuran acetogenins.Acetogenins: Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Sperm Immobilizing Agents: Chemical substances with sperm immobilizing activity used as topically administered vaginal contraceptives.Nutritional Requirements: The amounts of various substances in food needed by an organism to sustain healthy life.Fruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Dietary Fiber: The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Agave: A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.Nematode Infections: Infections by nematodes, general or unspecified.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)Trichuris: A genus of nematode worms comprising the whipworms.Intervertebral Disc: Any of the 23 plates of fibrocartilage found between the bodies of adjacent VERTEBRAE.Gastrula: The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Diskectomy, Percutaneous: Percutaneous excision of a herniated or displaced INTERVERTEBRAL DISC by posterolateral approach, always remaining outside the spinal canal. Percutaneous nucleotomy was first described by Hijikata in Japan in 1975. In 1985 Onik introduced automated percutaneous nucleotomy which consists in percutaneous aspiration of the nucleus pulposus. It is carried out under local anesthesia, thus reducing the surgical insult and requiring brief hospitalization, often performed on an outpatient basis. It appears to be a well-tolerated alternative to surgical diskectomy and chymopapain nucleolysis.Intervertebral Disc Degeneration: Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Bufanolides: Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Professional Corporations: Legally authorized corporations owned and managed by one or more professionals (medical, dental, legal) in which the income is ascribed primarily to the professional activities of the owners or stockholders.Mechanical Thrombolysis: Procedures to cause the disintegration of THROMBI by physical interventions.Schiff Bases: Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)Fissure in Ano: A painful linear ulcer at the margin of the anus. It appears as a crack or slit in the mucous membrane of the anus and is very painful and difficult to heal. (Dorland, 27th ed & Stedman, 25th ed)Pit and Fissure Sealants: Agents used to occlude dental enamel pits and fissures in the prevention of dental caries.Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Cell Migration Assays, Leukocyte: Assays that measure the rate of migration of LEUKOCYTES. They may involve a variety of techniques such as measuring the movement of leukocytes through substrates such as AGAROSE gels or the rate of exit of cells from a glass capillary.Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.

Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (1/37)

Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells.  (+info)

Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. (2/37)

This single-blind randomised clinical trial compared osteopathic manipulative treatment with chemonucleolysis (used as a control of known efficacy) for symptomatic lumbar disc herniation. Forty patients with sciatica due to this diagnosis (confirmed by imaging) were treated either by chemonucleolysis or manipulation. Outcomes (leg pain, back pain and self-reported disability) were measured at 2 weeks, 6 weeks and 12 months. The mean values for all outcomes improved in both groups. By 12 months, there was no statistically significant difference in outcome between the treatments, but manipulation produced a statistically significant greater improvement for back pain and disability in the first few weeks. A similar number from both groups required additional orthopaedic intervention; there were no serious complications. Crude cost analysis suggested an overall financial advantage from manipulation. Because osteopathic manipulation produced a 12-month outcome that was equivalent to chemonucleolysis, it can be considered as an option for the treatment of symptomatic lumbar disc herniation, at least in the absence of clear indications for surgery. Further study into the value of manipulation at a more acute stage is warranted.  (+info)

Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental study. (3/37)

Although chemonucleolysis with chymopapain is a long-established treatment for lumbar intervertebral disc herniation, serious complications have been reported. Accordingly, alternative substances for chemonucleolysis have been sought. The main beneficial effect of chemonucleolysis derives from the decrease in intradiscal pressure. Several previous studies have investigated the relationship between physiological saline injection and disc mechanics in cadaveric specimens [2, 5, 16]. However, no previous study has assessed the intradiscal pressure after intradiscal injection of "hypertonic saline" in living animals. The present study compared the changes in intradiscal pressure after intradiscal injection of hypertonic saline with those after chymopapain injection. The lumbar intervertebral discs of 26 living rabbits were examined: 10% hypertonic saline was injected in ten rabbits, and chymopapain (10 pikokatal units) was injected intradiscally in another ten, with the remaining six being used as controls. The intradiscal pressure was measured at 1, 4, and 12 weeks after injection. The intradiscal pressure of the hypertonic saline-injected group at 4 weeks was significantly lower than that of the control group, but by 12 weeks it had recovered. On the other hand, that of the chymopapain-injected group remained significantly lower than that of the control group at 12 weeks. The results of this study found that hypertonic saline injected into the intervertebral discs temporarily decreased the intradiscal pressure.  (+info)

Chemonucleolysis: the state of the art. (4/37)

This review presents the history of chemonucleolysis, the techniques, indications, contraindications, and complications. Presenting an historical overview and comparison of success rates with surgical discectomy may provide a fresh understanding of the controversy surrounding chemonucleolysis and establish its efficacy in relation to more invasive treatments. A review of the literature from 1973 through 1998 for chemonucleolysis, open discectomy, and microdiscectomy provided published success rates for these procedures, and a mean rate with standard deviation was determined. In the experience and opinion of the authors, chemonucleolysis remains a viable alternative for patients who have exhausted all conservative means of treatment. Proper patient selection leads to success rates comparable to open discectomy and microdiscectomy.  (+info)

Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water. (5/37)

BACKGROUND: This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI) of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. RESULTS: The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. CONCLUSION: The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn.H2O.Sn) of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.  (+info)

The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. (6/37)

OBJECTIVE: The purpose of this work was to test the effect of inhibition of bone remodeling, through the use of the bisphosphonate, zoledronic acid, on cartilage matrix damage in an animal model of cartilage matrix damage. DESIGN: New Zealand white rabbits were divided into four groups for treatment purposes: (1) untreated controls; (2) injected into one knee joint with the cartilage matrix degradation enzyme, chymopapain; (3) injected into one knee joint with chymopapain and also given subcutaneous injections of the bisphosphonate, zoledronic acid, three times per week until sacrifice at either day 28 or 56 post-chymopapain-injection; (4) received only the zoledronic acid injections. At sacrifice, the knee joints were examined grossly and histologically, and biochemically for proteoglycan content. Urine samples were analysed, at intervals, for levels of collagen cross-links which are biochemical markers of cartilage and bone. RESULTS: Animals receiving both intraarticular chymopapain injections and subcutaneous zoledronic acid injections displayed a significantly lower degree of grossly and histologically detectable cartilage degeneration on the tibial articular surfaces (the articular surface displaying the greatest degree of degeneration) than did animals only receiving the chymopapain injections. In addition, urinary levels of collagen cross-links for bone and cartilage were significantly higher in those animals only receiving chymopapain injections. CONCLUSION: The bone resorption observed after chymopapain injection into the rabbit knee joint can be inhibited through the use of the bisphosphonate, zoledronic acid. Furthermore, zoledronic acid does not increase the level of cartilage degeneration and appears to provide some level of chondroprotection in this model.  (+info)

Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. (7/37)

OBJECTIVE: To determine if oral glucosamine (GlcN) improves joint biology after acute damage by a protease. METHODS: The effect of 8 weeks of dietary GlcN (20 or 100 mg/kg/day) on knee joint cartilage was evaluated in 2.2-kg male NZW rabbits with and without damage introduced by intraarticular injection of chymopapain (CP). Cartilage was evaluated histologically and scored according to the Mankin scale. Analyses of total hydroxyproline and glycosaminoglycan (GAG) contents and reverse transcription-polymerase chain reaction (RT-PCR) analysis of selected genes were performed. RESULTS: After 8 weeks, there was no effect of GlcN on the GAG content of normal cartilage. Both levels of GlcN treatment significantly increased the sulfated GAG content in the cartilage of the medial femoral condyle in damaged and contralateral knees, but did not change the collagen content. In CP-injected knees, there was still some loss of surface proteoglycan (PG) that was not completely corrected by dietary GlcN. Even after 8 weeks, levels of messenger RNA (mRNA) detected by RT-PCR showed changes indicative of damage and repair, such as elevated type II collagen mRNA, and these levels were not influenced by GlcN treatment. Meniscal GAG content was increased in the contralateral knee of rabbits receiving high-dose GlcN, but was decreased in those receiving no GlcN or low-dose GlcN. Neither diet nor treatment affected the meniscal collagen content. CONCLUSION: These results suggest that oral GlcN treatment might be useful in a situation where GlcN is limiting, such as where there is a rapid replacement of cartilage PG.  (+info)

Chemonucleolysis. (8/37)

A prospective study of 480 patients who underwent enzymatic dissolution of the nucleus pulposus with chymopapain is reported. Seventy per cent of patients with the clincial criteria for a disc herniation had a favourable response to chemonucleolysis. The commonest cause of failure was persistent back pain. In patients with sequestered discs or lateral recess stenosis surgical intervention was not made more difficult by chemonucleolysis. Those with a previous operation, spinal stenosis or psychogenic components to the disability had very poor results. Complications were few and easily managed.  (+info)

*Caricain

Zucker, S.; Buttle, D.J.; Nicklin, M.J.H.; Barrett, A.J. (1985). "Proteolytic activities of papain, chymopapain and papaya ... Robinson, G.W. (1975). "Isolation and characterization of papaya peptidase A from commercial chymopapain". Biochemistry. 14: ... chymopapain S, Pp) is an enzyme. This enzyme catalyses the following chemical reaction Hydrolysis of proteins with broad ... multiple forms of chymopapain A and papaya proteinase". Biochem. J. 228: 525-527. PMC 1145013 . PMID 4015629. ...

*Glycyl endopeptidase

Polgár, L. (1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochim. Biophys. Acta. ... Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya ... proteinase 4, PPIV, chymopapain M) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage: ...

*Parviz Kambin

"Transforaminal Posterolateral Endoscopic Discectomy With or Without the Combination of a Low-Dose Chymopapain: A Prospective ...

*Crotalidae polyvalent immune fab

Patients with allergies to papain, chymopapain, other papaya extracts or the pineapple enzyme bromelain may also be at risk for ...

*Ficain

... and chymopapain. It is one of the most commonly used for differentiating many blood group antigens: For example, it destroys M ...

*List of MeSH codes (D08)

... chymopapain MeSH D08.811.277.656.300.215.350 --- ficain MeSH D08.811.277.656.300.215.585 --- papain MeSH D08.811.277.656. ...

*List of drugs: Cf-Ch

Chronovera Chronulac Chymex Chymodiactin chymopapain (INN) chymotrypsin (INN). ...

*ATC code M09

M09AA01 Hydroquinine M09AA72 Quinine, combinations with psycholeptics M09AB01 Chymopapain M09AB02 Collagenase clostridium ...

*List of EC numbers (EC 3)

... chymopapain, now EC 3.4.22.6 EC 3.4.4.12: ficin, now EC 3.4.22.3 EC 3.4.4.13: thrombin, now EC 3.4.21.5 EC 3.4.4.14: plasmin, ... chymopapain EC 3.4.22.7: asclepain EC 3.4.22.8: clostripain EC 3.4.22.9: yeast proteinase B. Now EC 3.4.21.48, cerevisin EC 3.4 ...

*Chymopapain

... (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death. Papain Chymopapain ... Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral ... The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing ...
Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and significantly lower than those of papain or ficin. The environment of the ...
Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
ment of back pain; it consists of a percutaneous intradiskal ment of the disk, we performed a concomitant injection of intra- injection that dissolves the nucleus pulposus and lowers in- articular steroids in the adjacent facet joints in all patients.9 tradiskal pressure. Several years ago, the most widely used sub- Procedures were performed with local anesthetic, under surgical stance for this was chymopapain, which had an efficacy of conditions and controlled digital fluoroscopy. A diskography was close to 80% in lumbar disk herniations and close to 85% in performed before RGE nucleolysis. The dose of RGE injected into the cervical disk hernias1-3 but was withdrawn from the market cervical disk was 0.2- 0.3 mL. Intradiskal injection of 1-2 mg of gen- due, in part, to anaphylactic reactions to this enzyme.4 After tamicin was systematically performed in all the cases at the end of the this, the search for a new drug that could have the same effi- procedure to prevent infection. At least 1 facet ...
We carry a limited range of rongeurs and spinal instruments following requests from veterinary surgeons, however our supplier carries a full range of instruments within this field so if you need something we dont list just ask and we give you a quote. Similarly if you have an idea for a new instrument or modification of an existing instrument we would be very keen to help make your idea reality. ...
Papain is also known as papaya proteinase-I which is an enzyme present in papaya. Papain is an important digestive enzyme which breakdown tough protein fibers. Papain is very stable also at very elevated temperatures. Papain latex is a rich source of cysteine endopeptidases including chymopapain, caricain and glycyl endopeptidase. Papain is traditionally used as a meat tenderizer and also used in skin burns, skin ulcers, wounds etc. Some of the common uses of papain are it boosts digestion, treats skin and wound, resistant to fungus, supports immune system and source of antioxidant etc. As papain is source of antioxidant, it is commonly used in food preservation to reduce bacterial infestations and spoilage of food due to oxidation.. Market Segmentation: Papain. The Papain market is segmented on the basis of its applications in different industries like food industry, cosmetic industry, pharmaceutical industry and chemical industry etc. Papain is used for food industry for food processing, as a ...
Papaya is likely safe when consumed in food amounts. Fermented papaya is possibly safe when used medicinally for up to three months. Use with caution in patients with bleeding disorders or those taking agents that may increase the risk of bleeding, in patients with diabetes or hypoglycemia or those taking agents that affect blood sugar, and in patients with autoimmune disorders or those using agents that affect the immune system. Use papaya seed extract and the papaya enzyme papain with caution. Use cautiously with vitamin A or retinoids, beta-carotene or carotene-containing foods, iron or iron-rich foods, sodium, potassium supplements, or agents that alter potassium levels. Avoid in patients with a known allergy or hypersensitivity to papaya, its components (including papaya juice, papaya flower pollen, papain, and chymopapain), members of the Caricaceae family, or latex. Cross sensitivity between kiwi and papaya, as well as papain, has been reported. Severe life-threatening allergic reactions ...
Introduction: Over centuries, Carica papaya (papaya) has been used as a nutritious and medicinal plant. In view of its medicinal uses, our group focused on aqueous leaves extract of papaya and tried to determine its antimicrobial (using bacterial strains i.e. gram positive and gram negative ones) and anti-inflammatory (virally infected human whole blood) activities. The protein content of the plant and its secondary metabolites were also analysed qualitatively.Methods: The protein content from aqueous leaves extract of C. papaya was quantified using Nanodrop method. ELISA studies were conducted in order to determine the antibody production against ovalbumin (OVA) using papaya aqueous leaves extract. Also, its antigen specific proliferation in virally infected human whole blood samples was determined through MTT assay. In addition, antimicrobial studies (using gram positive and gram negative strains) and cytotoxicity were also studied.Results: The aqueous leaves extract of papaya showed enhancement in
Papaya Tainung (Carica papaya), a red commercial variety, is deliciously sweet & produces abundant fruits that weigh from 3 to 5 pounds. Excellent for pots.
Buy or license direct from the photographer this stunning image of : Toucan (Ramphastidae), In A Carica Papaya Eating Its Juicy Fruit
Prices in US$ apply to orders placed in the Americas only. Prices in GBP apply to orders placed in Great Britain only. Prices in € represent the retail prices valid in Germany (unless otherwise indicated). Prices are subject to change without notice. Prices do not include postage and handling if applicable. RRP: Recommended Retail Price ...
Superior quality bulk Papaya Leaf available from Starwest - offering the finest chinese, craft, culinary, and therapeutic herbs since 1975.
The benefits of papaya are both internal and external because in addition to improving your digestion and strengthening your immune system, papaya also helps to prevent cellular damage ...
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The normal usage of papaya seeds is 1 tbsp. of them. This dosage is enough to get rid of the all toxins in the liver. Researches proved that these seeds prevent cirrhosis. Consume 5 papaya seeds, two times on a daily basis for 30 days continuously.. Or, you can grind them, crush them if the seeds are fresh in a mortar, and then add them to a refreshing lime juice. Drink this treatment twice per day for 30 days.. Promote Digestive Wellness. Papaya is ideal for digestion, and papaya seeds are rich in potent anti-parasite and antibacterial properties which remove the hazardous microorganisms in the intestinal tract. Moreover, papaya provides powerful anti-pathogenic properties that prove you need to eat 1 tbsp. of these seeds to prevent food poisoning and to eliminate bacteria that provoke digestion problems.. Reduce Swelling in Inflammatory Diseases. Papaya consists of 2 amazing enzymes, papain and chymopapain, which due to their powerful anti-inflammatory properties, they soothe swelling in case ...
... aids in the breakdown and metabolism of protein, exhibits anti-ulcer activity and helps to relieve indigestion. Papaya leaf contains the powerful proteolytic enzymes, papain and chymopapain, which digest proteins, small peptides, amides and esters. Their activity extends to carbohydrate and fat, and they are said to be more effective than naturally- occurring proteases like pepsin and trypsin. Since stomach ailments are often the direct result of indigestion, papaya leaf juice may help prevent and remedy these by increasing digestive processes, as the digestive properties of papain are well established ...
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Owoyele, Bamidele V., Adebukola, Olubori M., Funmilayo, Adeoye A, Soladoye, Aydoele O. 2008. Anti-inflammatory activities of ethanolic extract of Carica papaya Leaves. Inflammopharmacology 16 (2008) 168-173.. Papaya 2002. ,URL: http://www.herbs2000.com/herbs/herbs_papaya.htm, Accessed 28 March 2011. Papaya 2011. ,URL: http://www.hort.purdue.edu/newcrop/morton/papaya_ars.html#Origin%20and%20D istribution, Accessed 28 March 2011. Papayas. ,URL: http://www.innvista.com/health/foods/fruits/papayas.htm,. Accessed March 23rd 2011. Papaya Nutritional Information and Facts 2005. ,URL: http://www.juicing-for- health.com/papaya.html, Accessed 28 March 2011.. Phylum Magnoliophyta. ,URL: http://people.uvawise.edu/swvaflora/Magnoliophyta.html,. Accessed March 12th 2011.. ...
Papaya orchard. Fruit growing on papaya trees, Carica papaya, in an orchard. Papaya is also known as the common pawpaw. The tree produces large, spherical fruit which may be eaten at breakfast, in salads or for dessert. Papaya leaves can be wrapped around meat when it is cooked. While it is known that papaya trees are native to the New World, their exact origin is uncertain. Photographed in Hawaii, USA. - Stock Image E768/0165
Carica papaya L. is a scrub like a tree with the upright stalk and round. The top can be branch or not, side of that like a spons and hollow, in the outside a lot of leaf scars. The height of the tree around 2,5-10 m, petiole hollow round, the length around 2,5-10 m, round leaf or oval, bone of the leaves are finger shape, serrated edge, sharing such as finger, pointed tip with diameter around 25-75 cm, the top is green, the bottom is light green, slippery, and gloomy, each of three circle stalk trere are 8 leaves. The flowers almost always unisexual or dioecious, but mostly with several hermaphrodite flower in the staminate bouquet. The staminate in the bunches that same with tassel and long stalk, very small petals, the crown like a cream trumpet, with five edge, and long tube, slim, spin edge in the bud, anthers short stemmed, and the pistillate mostly stand-alone, the crown leaves loose and almost loose, cream, ovary tipped one, anthers are five. This plant can be found almost in the whole ...
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This is a clinical study looking at the effectiveness and safety of a new device call The Paradise System to use for renal denervation in patients who have mild to resistant hypertension. The study is divided into two groups, those on one to two anti hypertensive medications and those on three or more. For those only taking one or two medications, they will stop their current blood pressure medication while monitoring their blood pressure. Those who are taking 3 or more blood pressure medications will stop their current medication regime and be given one of two combination medications while monitoring their blood pressure. In each of the groups have the patients, if and when they continue to meet study inclusion criteria, will be randomized to undergo a renal denervation procedure using the new system vs no procedure. Their assignment will not be made known to them. All groups will be follow up to 3 years but for patients who did not initially have the procedure will be allowed to do so after ...
The papaya tree is one of the most distinctive plants on earth. It is generally 4 to 5 meters tall and unbranched, but old plants may be 10 meters tall. The trunk looks a little like an upside-down, gray carrot. This plant has huge leaves with very long petioles and are clustered near the top of the tree, because the lower ones are shed, leaving large, circular scars on the bark. The stem is soft and weak because it has very flimsy wood (secondary xylem) and a hollow center. Once a plant starts to produce, there is a continuous supply of fruits. All one has to do is to climbing to harvest the lowermost papaya fruit.. The ripe fruit has a yellow and green skin, often with tints of red and orange, and a sweet, semi-firm, yellow-orange pulp. Within the central cavity of the fruit are hundreds of dark seeds that almost appear bluish when the fruit is cut open; they are about the size of small peas and are attached to the pulp. Papaya fruit is most commonly eaten fresh for dessert or made into a ...
The large oval fruits of this "Melon tree" are attached in clusters just under its umbrella of snowflake shaped leaves. Tropical. Makes a very handsome indoor ornamental tree if you provide sufficient warmth and bright light. With ideal conditions will bear fruit in 1 year. Self pollinating. Mature hgt. 18'-25' Growing Instructions & Tips: Plant at 1/2" depth using well draining soil mixture. Keep warm and damp - not wet. Requires bright light. Fertilize every two weeks.
Papaya - Get complete information on papaya fruit, green papaya, papaya tree, papaya plants, fresh papaya uses, health benefits of papaya fruits and papaya suppliers, green papaya exporters from India.
Papaya plants (Carica papaya), commonly referred to as trees, are actually very large herbaceous perennials, usually with a short life span (but capable of living up to 20 years). Papayas produce large fruit with very sweet, yellow to red-orange-colored flesh. They are not difficult to grow when given a site with ...
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Agenda Presentasi Pendahuluan Aspek Bioteknologi Struktur Papain Teori mengenai Papain Isolasi dan Karakterisasi Papain dari Pepaya (Carica papaya)
What is Carica? It is is a type of papaya fruit, often called mountain papaya and it contains many beneficial vitamins. What are interesting and unique from
One Piece765.5: L\sola del destino Minion (Digital Colored) pagina 1 (Carica immagini: 6), One Piece Manga italiano, read One Piece891 on-line
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Anggotaa DPR RI dari Fraksi Partai Kebangkitan Bangsa (PKB) Drs. H. Taufiq R. Abdullah mendesak kepada pemerintah agar bersungguh-sungguh memberikan dukungan untuk pengembangan hasil pertanian khas Ba
Todays article talks about the many beneficial properties you can get from eating just a slice of papaya every day. Dont miss it!
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View Notes - pom212_papaya_and_guava_2005_handout from POM 212 at UC Davis. Papaya Carica papaya • Fleshy berry • Also known as pawpaw • Cultivars vary in shape and size - Elongated to
Carica papaya L. leaves have been used in ethnomedicine for the treatment of fevers and cancers. Despite its benefits, very few studies on their potential toxicity have been described. The aim of the present study was to characterize the chemical composition of the leaf extract from Sekaki C. papaya cultivar by UPLC-TripleTOF-ESI-MS and to investigate the sub-acute oral toxicity in Sprague Dawley rats at doses of 0.01, 0.14 and 2 g/kg by examining the general behavior, clinical signs, hematological parameters, serum biochemistry and histopathology changes. A total of twelve compounds consisting of one piperidine alkaloid, two organic acids, six malic acid derivatives, and four flavonol glycosides were characterized or tentatively identified in the C. papaya leaf extract. In the sub-acute study, the C. papaya extract did not cause mortality nor were treatment-related changes in body weight, food intake, water level, and hematological parameters observed between treatment and control groups. Some
Dr. Steve Shoshany is a new breed of New York Chiropractor. As a New York Chiropractor, Dr. Shoshany has many interesting experiences. This New York Chiropractor blog is a journal of the day to day happenings of a New York Chiropractor and his New York Chiropractor clinic.Using the exclusive DRX 9000 he shares his results with this Non Surgical Spinal Decompression with all that are interested.This is an excellent treatment for those with a herniated disc and back pain. ...
Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests ELISA Kit 800-160-CPP Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests ELISA Kit 800-160-CPP
Our results show that the intraperitoneal administration of STZ to rats significantly increased glucose blood levels four days after injection, as well as decreased body weight. In addition, other diabetes-related signs were observed. These results agree with previous observations that have employed this model and that also report loss of body weight [13, 14].. Several reports suggest that this model of type 1 diabetes induced by STZ is adequate to evaluate the properties of leaves or fruits from different plants [15-17]. In the present study, the aqueous extract of C. papaya maintained the body weight of diabetic rats during treatment. Weight loss is a main sign of diabetes but its mechanism is not clear. It could be due to many factors such as loss of appetite, increased muscle waste and loss of tissue proteins [15, 18, 19]. In addition, the administration of the aqueous extract of C. papaya decreased water consumption. Other natural products also produce a decrease in both water intake and ...
Intradiscal electrothermal therapy (IDET) is a minimally invasive procedure for treating lower-back pain caused by worn spinal discs. IDET uses a heating device on the affected disc; the heat that it generates destroys nerve fibers, toughens the disc
id":422596706315,"title":"Organic Island Paw Paw Lip Salve 25ml","handle":"organic-island-paw-paw-lip-salve-25ml","description":"\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eDiscover the power of Paw Paw More!\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=ltr\u003e\u003cspan\u003eScientifically formulated to protect, replenish and nourish skin while maintaining hydration. The \u003c\/span\u003e\u003cspan\u003ePaw Paw Lip Salve\u003c\/span\u003e\u003cspan\u003e uses three types of paw paw enzymes, including NOP Organic Dehydrasome Pumpkin Papaya™, Papain (Papaya Enzyme) \u0026amp; Carica Papaya Fruit Extract (Paw Paw) to create a uniquely powerful formula that effectively moisturises and soothes all year round. Technologically advanced delivery systems OliveM1000 Crystal Skin and Si02 Matrix™ help to readily absorb these high quality organic ingredients directly into your skin, ensuring fast results you can see and feel. ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
carica definition: the nature genus for the Caricaceae; consisting of tropical United states trees; the papayas.; A genus of plants, normal order Papayaceæ, consisting of about 20 types, that are natives…
NAC GOOD FOR ** **URIs particularly useful for treating upper respiratory and lung infections; mucolytic classic study published in 1997: may not even notice being sick NAC significantly reduced flu-like episodes **OCD case report of a single patient with OCD who benefited from taking NAC was…
know the benefits of drinking papaya juice in treating weight loss, diabetes, heart diseases, acne and much more. Papaya juice is one of the most healthy and nutritious juices, a must for you all
... Cena je za pakovanje od 1000 Semena. Patuljasta - mini papaja daje plodove vec nakon 6 do 8 meseci a naraste najvise
Na tej strani se boš lahko predstavila, dodala svojo sliko, povedala o sebi, kaj počneš, na kaj si ponosna, kaj dobrega si naredila, da se počutiš - kot carica.
Papain is a medicine available in a number of countries worldwide. A list of US medications equivalent to Papain is available on the Drugs.com website.
p,,strong,Aim ,/strong, The study aims at determining the possible effects of Carica papaya leaf juice and hydrocortisone in increasing the platelet count in thrombocytopenia similar to dengue fever.,/p, ,p,,strong,Methodology ,/strong, The study was carried out on 24 Long Evans Norwegian strain healthy rats to investigate the comparative platelet increasing effect of Carica papaya leaf juice and hydrocortisone in experimentally induced thrombocytopenic rats. Thrombocytopenia was induced by 3 doses of cyclophosphamide (100mg/kg body weight) given subcutaneously. The rats were divided into 4 groups comprising of six animals in each group. These groups included a normal control and a cyclophosphamide induced thrombocytopenic control and the remaining two cyclophosphamide induced thrombocytopenic groups were administered Carica papaya leaf juice and hydrocortisone respectively.,/p, ,p,The duration of study was 15 days. The clotting time was determined on the 15th day although blood samples were ...
Our consortium partners have developed and studied stemcell-based, regenerative therapies with encouraging results in phase 1 and 2a trials. Patients exhibited rapid and progressive improvement of functional and pain indexes by 50% within 6 months and by 65% to 78% after 1 year with no side effects. In addition, MRI T2 relaxation measurements demonstrated a significant improvement. To develop the worlds first rigorously proven, effective treatment of DDD, RESPINE aims to assess, via a multicentre, randomized, controlled, phase 2b clinical trial including 112 patients with DDD, the efficacy of an allogenic intervertebral mesenchymal stem cell (MSC)-based therapy. This innovative therapy aims to rapidly (within 3 months) and sustainably (at least 24 months) reduce pain and disability. In addition, the consortium aims to provide new knowledge on immune response & safety associated with allogeneic BM-MSC intradiscal injection. This simple procedure would be cost-effective, minimally invasive, and ...
Siang itu beberapa perempuan duduk di teras rumah mengupas buah berwarna kuning yang bentuknya mirip dengan belimbing. Setelah diperhatikan lebih dekat, buah itu bukan belimbing, melainkan Carica. Carica? Nama yang agak unik ya? Ternyata diambil dari nama latinnya pepaya yaitu Carica. Buah yang lebih sering disebut pepaya hutan ini tumbuh di daerah Dieng, Wonosobo, Jawa Tengah. Rasa buah aslinya sepet tetapi rasa bijinya asam. Oleh para wanita ini, Carica diolah menjadi manisan yang enak sekali. Rasanya yang manis dan segar sangat cocok dijadikan hidangan buka puasa atau dinikmati saat matahari sedang terik-teriknya. ...
The main antioxidant in Papaya is papain, which gives it that rotten smell. Unripe papayas contain more papain than ripe ones. The ripeness of a papaya can determine how nutritious it really is. One study 1 looked at the nutrient content of ripe and unripe papayas and determined that several different antioxidants increased as a papaya ripened. They saw that certain carotenoids, which is the family that vitamin A (beta-carotene) comes from, increased dramatically. The amount of lycopene increased nearly 10x in ripened papayas vs unripe ones and beta-carotene more than doubled its original amount. Vitamin C more than doubled in ripened papayas as well. Basically, the more rotten your papaya smells, the healthier it is. However, dont eat papayas that have actually gone rotten. Papaya is very helpful with digestion and may also help treat all types of arthritis. How these things are connected is still unclear but it may have to do with fewer toxins in your body because enzymes in papaya help to ...
Masters dissertation (2011). Lischémie cérébrale, qui correspond à une interruption du flux sanguin causée par lobstruction dune artère cérébrale, est occasionnée dans plus de 80% des AVCs humains. Cette maladie neurologique est ... [more ▼]. Lischémie cérébrale, qui correspond à une interruption du flux sanguin causée par lobstruction dune artère cérébrale, est occasionnée dans plus de 80% des AVCs humains. Cette maladie neurologique est la seconde cause de mortalité dans les sociétés industrialisées et son impact est lourd sur les survivants. En effet, elle génère des déficits fonctionnels subsistant pendant des mois, voire des années. Ce travail sinscrit dans la perspective de développement dun traitement permettant une récupération fonctionnelle de ces déficits par la recherche de techniques permettant de mimer un AVC humain sur différentes souches de rongeurs. Le présent travail consiste en la mise en place dune batterie de tests comportementaux ...
in Revue Médicale de Liège (1997), 52(8), 515-519. LEntre-Sambre-et-Meuse a été le siège dune épidémie de néphropathie épidémique à Hantavirus (NE) en 199293. Cinq cas ont été rencontrés au CHU de Liège en moins dun an. Le virus responsable de cette ... [more ▼]. LEntre-Sambre-et-Meuse a été le siège dune épidémie de néphropathie épidémique à Hantavirus (NE) en 199293. Cinq cas ont été rencontrés au CHU de Liège en moins dun an. Le virus responsable de cette affection appartient à la famille dès Hantavirus dont il existe huit sérotypes aux caractéristiques propres en terme de vecteur (rongeurs), de distribution géographique et de pathogénicité. Les pathologies induites chez lhomme vont de la néphropathie épidémique à Hantavirus - dévolution le plus souvent bénigne- au syndrome pulmonaire à Hantavirus (SPH) - fréquemment mortel - en passant par la fièvre hémorragique avec syndrome rénal (FHSR) de sévérité intermédiaire. Dans nos ...
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Papaya today is eaten around the world. You can grow it in any tropical country. But the home of the papaya is tropical Latin America. There are two major sizes of papaya: modern commercial papaya, and a wild papaya ( Carica cauliflora ), with roun
Bromelain is a protein-digesting enzyme (protease) extracted from the flesh and stem of the pineapple plant. Bromelain is a natural anti-inflammatory enzyme.
Bromelain list and information including what is Bromelain, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Papaya list and information including what is Papaya, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
Quadrante paillonné su smalto Grand Feu di colore blu. Centro opalino argentato. Cassa e rehaut in oro rosso 18 carati. Movimento meccanico a carica automatica. Riserva di carica di 68 ore. Diametro 43 mm. Numerus Clausus a 8 esemplari.
Enzymes are biological catalysts that speed up chemical reactions in your body. Bromelain and serrapeptase are enzymes that accelerate the break down and digestion of proteins. Bromelain is produced from the fruit and stems of pineapples.
A glass of papaya juice is an excellent way to get essential vitamins and minerals. It contains and the digestive enzyme called papain.
Ronde de Bordeaux s t tlila term s f gef k, sharon gy m lcs elad : Ficus carica Violette de Sollies- F gefa kont. 30 ...
Qualcuno sta avendo problemi con etch eil modulo r8169? Il mio carica correttamente ma appena provo a mandare su linterfaccia mi risponde con un mesto link down nonostante ovviamente tutto sia collegato e funzionante. Non solo, rimuovendo il modulo e tentando di ricaricarlo mi sputa fuori un bell error -22, fallendo miseramente... Che faccio, provo a passare a Lenny? Thanks in advance! -- Dario Fiumicello GPG Key ID: 0xC5EE3345 (hkp://pgp.mit.edu ...
Quadrante in smalto Grand Feu di colore avorio Cassa in oro rosso 18 carati. Movimento automatico. Riserva di carica di 68 ore. Diametro 43 mm. Numerus Clausus a 88 esemplari
A renal denervation system includes an ablation catheter and an inflation balloon. The renal denervation catheter is insertable into a renal artery to perform a renal denervation procedure. The inflation balloon is inflatable within the renal artery, wherein one of a blood pressure condition in the renal artery resulting from operation of the inflation balloon and a performance characteristic of the inflation balloon indicates efficacy of the renal denervation procedure.
In the 1930s, Mixter and Bar recognized the relationship between disc herniation and sciatica.1 In 1964, Smith was able to dissolve the nucleus pulposus via chemonucleolysis in a rabbit model via percutaneous enzymatic applications; this technique was later successfully applied in humans and later abandoned because of complications.2,3 In 1973, Kambin and Gellman initiated a percutaneous indirect spinal canal posterolateral extracanal nonvisualized approach through an anatomically safe triangle appropriately named Kambins triangle (see Fig. 93-1).4 Then Hijikata et al. in 1975 reported the first percutaneous nucleotomy for posterolateral lumbar disc herniations using arthroscopic techniques.5-7 Kambin and Gellman reported a 72% success rate for 136 patients treated with a percutaneous lateral technique similar to method adopted by Hijikata.8 This success was due to a reduction of intradiscal pressure by forming fenestrations in the outer annulus. In 1983, Frost and Hausmann first introduced a ...
IVD degeneration is mostly characterized by changes in disc morphology and composition of the extracellular matrix, as well as loss of disc cells and water content. To achieve optimal disc repair, the ideal therapy should preserve the intact architecture of the disc tissue as much as possible, while increasing the synthesis of water-absorbing molecules, such as type II collagen and proteoglycan, to restore its shock-cushion function. Most of the new biology-based strategies for disc repair are based upon these principles, including autologous cell transplantation, growth factor injection, or gene delivery. The present study provides a promising alternative that is potentially more easily translated to the clinical setting. Our results show that a single dose of simvastatin loaded in PEG-PLGA-PEG gel injected into the NP of rat discs up-regulates mRNA levels of collagen type II and the differentiation index (the ratio of type II to type I collagen). The improvements were also evident in the ...
Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dyslipidemia is characterized by abnormalities in blood lipid profiles. This study aims to determine the effect of ethanol extract of papaya seeds (Carica papaya L.) on lipid profile parameters, namely total cholesterol, triglycerides, LDL (Low Density Lipoprotein), and HDL (High Density Lipoprotein) dyslipidemia in rats This study examination of characteristic, . phytochemical screening of simplicia and ethanol extract of papaya seeds, and testing of ethanol extract of papaya seeds on lipid profile. This study uses an experimental method with post-test only control group design with 20 Wistar rats were then divided randomly into 5 groups. Ethanol extract of papaya seeds administered orally at a dose of 200 mg/kg bw and 400 mg/kg bw. Simvastatin dose of 0.9 mg/kg bw administered orally as a positive control. Quail egg yolk 1% body weight and propylthiouracil dose of 9 mg/kg bw administered orally as a control for comparison. ...
Introduction: The present study was conducted to evaluate the antioxidant and immunostimulant effects of The Carica papaya fruit aqueous extract (CPF, Caricaceae) against acrylamide induced oxidative stress and improvement of Immune functions which affected by free radicals liberating acrylamide in rats. Material and methods: Sixty male wistar albino rats (195-230g) were assigned to four groups, (fifteen/group). The first group used as control group and received normal physiological saline orally daily. The second group was supplemented with acrylamide 0.05% in drinking water. The third group was gastro-gavaged with 250 mg/kg of papaya fruit extract orally on daily basis. The fourth group was supplemented with acrylamide 0.05% in drinking water and gastro-gavaged with 250 mg/kg of papaya fruit extract orally on daily basis. The chosen dose of papaya fruit extract was based on the active pharmacological dose range obtained from the orientation study earlier conducted. The experimental period was ...
The study was conducted at the In Vitro Laboratory, Institut Pertanian Persekitaran Terkawal (IPPT), Faculty of Agriculture and Molecular and Cell Biology Laboratory, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor. The main objectives of the study were to develop in-vitro plantlet regeneration systems and to carry out preliminary studies of Agrobacterium-mediated gene transformation of Carica papaya L. cv. Eksotika. The study consisted of in-vitro plantlet regeneration through organogenesis, and somatic embryogenesis using different types of explant and different concentrations and combinations of plant growth regulators whereby the most appropriate system could be applied in the genetic transformation of the crop. The experiments were arranged in a completely randomized design (CRD). The study on organogenesis included shoot induction and rooting. On shoot induction, modified MS (Murashige and Skoog, 1962) medium supplemented with 500 mgL-1 ...
Oil rich Carica papaya Linn. (CPL) seed is currently discarded as waste. This research is aimed at ascertaining the lipid and antioxidant qualities of the oil in vivo(compared to groundnut oil). Four diets composed from the oil were fed to wistar rats for 32 days. The lipid profile and antioxidant status of the plasma, erythrocytes and brain were examined. The results showed significant reductions (P,0.05) in body weights (of rats fed with the 7-10 % oil diet), erythrocyte peroxidase activity, as well as cholesterol and phospholipids levels in brain. There was also a significant increase(P,0.05) in the reduced glutathione levels in the erythrocyte of rats fed with the 10 % oil diet. The brain weights were significantly increased (P,0.05) by all the CPL seed oil diets. The CPL seed oil quality is comparable to groundnut oil; but it is a better antioxidant source. Small quantities of 5-7% CPL oil in diets may be appropriate to prevent its deleterious effects on brain.. ...
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). Papain belongs to a family of related proteins with a wide variety of activities, including endopeptidases, aminopeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity. Members of the papain family are widespread, found in baculoviruses, eubacteria, yeast, and practically all protozoa, plants and mammals. The proteins are typically lysosomal or secreted, and proteolytic cleavage of the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals. Papain-like cysteine proteinases are essentially synthesised as inactive proenzymes (zymogens) with N-terminal propeptide regions. The activation process of these enzymes includes the removal of propeptide regions, which serve a variety of functions in vivo and in vitro. The pro-region is required for ...
Interruption of afferent input from the sinoaortic and cardiac baroreceptors resulted in a decrease in the correlation dimension and the greatest Lyapunov exponent of the nonlinear dynamic characteristics of synchronized RSNA that was different among Sprague-Dawley rats, WKY, and SHR. In Sprague-Dawley rats, the immediate responses to sinoaortic and cardiac baroreceptor denervation were qualitatively similar to those seen in previous studies7 in which 60 minutes was allowed to elapse between the completion of the denervation procedure and the collection of the experimental data. However, there are important quantitative differences in that the decrease in the correlation dimension was less in the present study (immediate, 2.42 versus 2.16, −11%) than in the previous study (60 minutes, 2.65 versus 1.64, −38%), while the situation was opposite for the greatest Lyapunov exponent (immediate, 0.199 versus 0.130, −35%; 60 minutes, 0.201 versus 0.177, −12%). With respect to central nervous ...
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; ...
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By 1998, it seemed that the Hawaiian papaya industry would die out due to PRSV. However, it was saved by the foresight of a dedicated group of plant pathologists and by the introduction of papayas that were genetically engineered to resist PRSV. In the mid 1980s after PRSV had spread on the island of Oahu, plant pathologists, who analyzed the future impact of PRSV on Hawaii, began research to find a control for it before it was a major threat to papaya production on the island of Hawaii. Scientists, working at Cornell University and in Hawaii, decided to use genetic engineering to make papaya resistant to PRSV. Copies of the coat protein gene from PRSV were inserted into papaya cells. Messenger RNAs produced by these genetic inserts interfere with the ability of PRSV to infect the papaya and to replicate in the papayas cells. Thus, the genetically engineered papayas are resistant to the virus.. After the years of development and careful testing, the first release of resistant papaya cultivars, ...
Dr. Rinky Kapoor provides expert advice on skin lightening and boosting injection therapies and its precautions for use by Dr Debraj Shome & Dr Rinky Kapoor, The Esthetic Clinics in Mumbai, Kolkata, Hyderabad, Surat, New Delhi across India
É difícil dissociar a Turma do Sereno da Família Mantovan. Na verdade a Turma do Sereno deve ser um "braço" da Famíla Mantovan. Eu digo isso baseado no carisma desse trio de ouro, Seu Anézio, "Ferpa" e "Nersão" (conforme a ordem na foto). Toda última quinta-feira do mês, após nossa peleja religiosa e inadiável, lá vamos nós para para um churrasco comandado por essa família. Na minha vida poucas vezes fui tão bem recebido num ambiente, como na primeira vez em que compareci a esse momento de reunião do grupo. Quando o Rafael me pediu essa carica, eu me senti a vontade para assumir a proposta com o maior entusiasmo pelo respeito e amizade que dedico a esta família. A sinergia é tanta que no dia da entrega da carica Seu Anézio veio de camisa azul. Em nome da Turma do Sereno eu agradeço e reverencio a Família Mantovan. Valeu Seu Anézio, "Ferpa" e "Nersão ...
The papaya (from Carib via Spanish), papaw, or pawpaw is the fruit of the plant Carica papaya, the sole species in the genus Carica of the plant family Caricaceae. It is native to the tropics of the Americas, and was first cultivated in Mexico several centuries before the emergence of the Mesoamerican classical civilizations ...
If you suffer from lower back pain, leg pain, or pain in your upper back and arms, you may be dealing with a disc problem. Learn about intradiscal care!
(2002) Zander et al. J Biomech. There is little information about the influence of bone graft size, position and elasticity on the mechanical behavior of the lumbar spine. Intersegmental motion, intradiscal pressure and stresses ...
Genestra Bromelain Papain+ - Genestra Bromelain Papain+ is a multi-enzymatic formulation of bromelain, papain and pancreatin. Com
Connect and collaborate with Marlenildo Ferreira Melo at Federal Rural University of the Semi-Arid, with research interests in Carica papaya L. and weed, on Mendeley.
|b|Fig Black Mission (Ficus carica) |/b||br|Black Mission Fig is the most famous fig in cultivation. It produces two sizeable crops a year and its sweet distinct fig flavor is delicious whether eaten fresh or dried. Grow in full sun outside in the ga
Facts about red papaya. Red papaya is a fruit that used to be relatively unknown outside of the tropics, but today you can find it just about any supermarket. The fruit is loaded with nutrients so there is much to be gained if this fruit strikes your fancy. One serving has high fiber and potassium, iron, calcium, plus the daily requirement of vitamin A and three days worth of vitamin C. Red papaya contains antioxidants which can protect from certain types of cancer, such as colon cancer, and is known to help with digestive problems.
Papaya, the fruit with amazing nutritional and medicinal features! Checkout 10 amazing health and nutritional benefits of papaya and nutrition facts of papaya.
Dogs can safely eat papaya. They can eat papaya seeds, too, but many do not like the peppery-flavor of the seeds. Papayas are an excellent source of antioxidants, B vitamins and electrolytes....
Provides the latest information on papaya genetics and genomics for papaya researchers and plant biologists Written by a team of experts in various
Papayas grow in the tropical regions of the New World. They grow in southern Mexico and further south into Central and South America. Another name for the papaya is the paw...
LiPhone ha unurgente bisogno di aumentare lautonomia della batteria. Se lo si utilizza in 3G, in una zona dove il segnale è debole, in poche ore si perderanno parecchi punti percentuali. Al
Buah figs segar bisa ditemukan sekitar akhir bulan Juli hingga awal November berasal dari Turki, Sekitar bulanAgustus-September berasal dari Yunani dan Perancis . Dan yang berasal dari Italia dan Israel sekitar bulan September hingga November . Sekitar bulan Desember ke Juli biasanya diimpor dari Brasil ...
Compare Us to Boston Medical and SAVE! Penis Injection Therapy for Treatment of ED for Men in NYC If you have any questions, to schedule a … ...
When I was young(er), I didnt like Papaya. I didnt think it had a great taste or a great smell. But as I grew up, I picked up a special liking towards this
To rid the body of excess wastes and toxins can be as simple as incorporating papaya into the diet. An inadequate diet can lead to numerous digestive...
Objective: To determine efficacy of radionucleoplasty infiltration in intervertebral disc herniation Background of Background Data: Radionucleoplasty is a new, minimally invasive procedure for the treatment of disc prolapse. The aim of the present study was to determine associations between the morphology of the basic disease, patient-specific factors and the outcome of the treatment.Disc prolapse is one of the important causes of low back pain radiating to limbs. Apart from conservative therapy all other forms of treatment aim at decompressing the nerve roots. These can be done by taking the disc out by surgery or by decompressing the foramen and disc by different interventions. The various treatment options have confused clinicians due to significant failure rate associated with different kinds of surgeries as well as with different interventions. Injecting a thermal wand fordisc prolapsehas developed as an alternative to chemonucleolysis and disc surgery owing to its high success rates, less ...
In SPYRAL HTN OFF-MED renal denervation patients, the 24-hour systolic ambulatory blood pressure (ABPM) declined 5.5mmHg, resulting in a 5mmHg difference from the sham control arm (p=0.041), and the diastolic AMBP declined 4.8mmHg, resulting in a 4.4mmHg difference from the sham control arm (p=0.002). Additionally, there were no reported cases of new or worsening renal failure, vascular complications, or other major adverse events, confirming the safety of the renal denervation procedure - even with a revised procedural approach that extended ablations into the kidneys branch arteries and an increase in total number of ablations compared with previous trials.. "After SYMPLICITY HTN-3, we learned a lot about the procedure itself, medication adherence and which patients may have less response to the renal denervation procedure-these insights have been incorporated into the revised clinical approach in the SPYRAL HTN program," said co-principal investigator David Kandzari, director of ...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. The dengue infection in mouse model was established by inoculation of non-mouse adapted New Guinea C strain dengue virus (DEN-2) in AG129 mice. The freeze-dried CPLJ compounds were identified by Ultra-High Performance Liquid Chromatography High Resolution Accurate Mass Spectrometry analysis. The infected AG129 mice were orally treated with 500 mg/kg/day and 1000 mg/kg/day of freeze-dried CPLJ, starting on day 1 post infection for 3 consecutive days. The blood samples were collected from submandibular vein for plasma NS1 assay and
Cathepsin Z, also called cathepsin X or cathepsin P, is a protein that in humans is encoded by the CTSZ gene. It is a member of the cysteine cathepsin protease family, which has 11 members. As one of the 11 cathepsins, cathepsin Z contains distinctive features from others. Cathepsin Z has been reported involved in cancer malignancy and inflammation. The CTSZ gene is located at 20q13.32 on chromosome 20, consisting of 6 exons. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. Cathepsin Z is characterized by an unusual and unique 3-amino acid insertion in the highly conserved region between the glutamine of the putative oxynion hole and the active site cysteine. The pro-region of cathepsin Z shares no significant similarity with other cathepsin family sequences. It contains only 41 amino acid residues without the conserved motif of ERFNIN or GNFD found in other cysteine proteinases. Besides, the proregion sequence ...
Back pain related to herniated discs is an extremely common condition and a frequent cause of chronic disability. Although many cases of acute low back pain will resolve with conservative care, a surgical decompression is often considered when the pain is unimproved and is clearly neuropathic in origin, resulting from irritation of the nerve roots. Open surgical treatment typically consists of some sort of discectomy, where the extruding material is excised. A variety of minimally invasive techniques have been investigated over the years as a treatment of low back pain related to disc disease. Techniques can be divided into techniques that are designed to remove or ablate disc material and thus decompress the disc include chemonucleolysis, automated percutaneous lumbar discectomy, laser discectomy, and most recently disc decompression using radiofrequency energy, referred to as a DISC nucleoplasty™. Automated percutaneous discectomy, laser discectomy and DISC nucleoplasty™ are the subjects ...

Chymopapain Injection Advanced Patient Information - Drugs.comChymopapain Injection Advanced Patient Information - Drugs.com

Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and ... Uses For chymopapain. Chymopapain is injected directly into a herniated ("slipped) disk in the spine to dissolve part of the ... Proper Use of chymopapain. Dosing. The dose of chymopapain will be different for different patients. Follow your doctors ... Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain ...
more infohttps://www.drugs.com/cons/chymopapain-injection.html

Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...

Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and ... Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ...
more infohttp://www.biochemj.org/content/233/1/119

Papaya Leaf JuicePapaya Leaf Juice

Papaya leaf contains the powerful proteolytic enzymes, papain and chymopapain, which digest proteins, small peptides, amides ...
more infohttp://www.drinks-health.com/2008/11/papaya-leaf-juice.html

Chymopapain - WikipediaChymopapain - Wikipedia

Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death. Papain Chymopapain ... Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral ... The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing ...
more infohttps://en.wikipedia.org/wiki/Chymopapain

Chymopapain (Injection Route) Proper Use - Mayo ClinicChymopapain (Injection Route) Proper Use - Mayo Clinic

The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. ...
more infohttps://www.mayoclinic.org/drugs-supplements/chymopapain-injection-route/proper-use/drg-20062811

chymopapain from papaya latex Global Market and Forecast Research : ReportsnReportschymopapain from papaya latex Global Market and Forecast Research : ReportsnReports

65 Pages Report] Check for Discount on chymopapain from papaya latex Global Market and Forecast Research report by ChemReport. ... chymopapain from papaya latex Global Market and Forecast Research Table of Contents Part 1: General Information of chymopapain ... Potential users of chymopapain from papaya latex The main trading companies of chymopapain from papaya latex List of Figures ... 2.2 Construction of Industry Chain of chymopapain from papaya latex Chapter 3: End User of chymopapain from papaya latex List ...
more infohttp://www.reportsnreports.com/reports/619546-chymopapain-from-papaya-latex-global-market-and-forecast-research.html

Federal Register
       :: 
      Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...Federal Register :: Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...

... chymopapain 10,000 units/vial injection) was not withdrawn from sale for reasons of safety or effectiveness. This determination ... Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness. ... This determination will allow FDA to Start Printed Page 3887approve abbreviated new drug applications (ANDAs) for chymopapain ... CHYMODIACTIN (chymopapain 10,000 units/vial injection) is the subject of NDA 18-663. CHYMODIACTIN is indicated for the ...
more infohttps://www.federalregister.gov/documents/2003/01/27/03-1742/determination-that-chymopapain-10000-unitsvial-injection-was-not-withdrawn-from-sale-for-reasons-of

Microvascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbitsMicrovascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbits

... Olmarker, K ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Animals, Cartilage, Cheek, Chondroitin Lyases, Chondroitinases and Chondroitin Lyases, Chymopapain, Cricetinae, Mesocricetus, ...
more infohttps://lup.lub.lu.se/search/publication/d808ca95-9c7e-4268-bd52-0908aa0f04c1

The Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton ReportThe Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton Report

Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many ... Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of ... There can be no question but that the M2H factor for chymopapain was one of highest ever recorded. Because it wasnt released ... Chemonucleolysis with chymopapain (or other enzymes such as collagenase) really werent a bad idea if qualified people were ...
more infohttp://www.burtonreport.com/InfSpine/MinInvasProcChemonucleolysis.htm

Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...

... unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. ... The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published ... A brush is useful in removing strands of nucleus loosened by chymopapain. ... significantly more nucleus is removed if chymopapain is used in addition to rongeurs. ...
more infohttps://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-8-122

Chymopapain Expert for Consulting, Expert WitnessChymopapain Expert for Consulting, Expert Witness

Experts available for chymopapain consulting, expert witness, or analyst services for business, legal, and technical ... Chymopapain Experts. The following experts are available as chymopapain consultants and chymopapain expert witnesses. ORC ... Definition: Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. ...
more infohttp://www1.orcexperts.com/experts.asp?strSearchType=all&strQuery=chymopapain

December 1985 - Volume 64 - Issue 12 - Contributor Index : Anesthesia & AnalgesiaDecember 1985 - Volume 64 - Issue 12 - Contributor Index : Anesthesia & Analgesia

Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ...
more infohttps://journals.lww.com/anesthesia-analgesia/pages/contributorindex.aspx?year=1985&issue=12000

Patent US4789732 - Bone morphogenetic protein composition - Google PatentsPatent US4789732 - Bone morphogenetic protein composition - Google Patents

... chymopapain; collagenase; tyrosinase;thermolysin; and nuclease (RNAase and DNAase).Partially degraded by pepsin and papain ...
more infohttp://www.google.ca/patents/US4789732

September 1986 - Volume 11 - Issue 7 - Contributor Index : SpineSeptember 1986 - Volume 11 - Issue 7 - Contributor Index : Spine

The Biochemistry of the Action of Chymopapain in Relief of Sciatica. BUTTLE, DAVID J.; ABRAHAMSON, MAGNUS; BARRETT, ALAN J. ... The Biochemistry of the Action of Chymopapain in Relief of Sciatica. BUTTLE, DAVID J.; ABRAHAMSON, MAGNUS; BARRETT, ALAN J. ... The Biochemistry of the Action of Chymopapain in Relief of Sciatica. BUTTLE, DAVID J.; ABRAHAMSON, MAGNUS; BARRETT, ALAN J. ...
more infohttps://journals.lww.com/spinejournal/pages/contributorindex.aspx?year=1986&issue=09000

PLA: Statutes & RulesPLA: Statutes & Rules

Drugs: Use of Chymopapain. *Chapter 25. Drugs: Biosimilar Biological Products. *Chapter 26. Drugs: Investigational Drug, ...
more infohttps://www.in.gov/pla/2545.htm

Enzyme Explorer Assay Library | Sigma-AldrichEnzyme Explorer Assay Library | Sigma-Aldrich

Chymopapain 3.4.22.6. Chymotrypsin 3.4.21.1. α-Chymotrypsin - Insoluble 3.4.21.1. α-Chymotrypsinogen A 3.4.21.1. ...
more infohttps://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/assay-library.html

Ivan Cheng, MD | Stanford Medicine ProfilesIvan Cheng, MD | Stanford Medicine Profiles

Chymopapain: a shot from the past. Pain practice Mitra, R., Wedemeyer, M., Cheng, I. 2008; 8 (4): 331-332 View details for DOI ...
more infohttps://med.stanford.edu/profiles/ivan-cheng

Device and method for dispensing medication to tissue lining a body cavity - KAPLOUN ILYADevice and method for dispensing medication to tissue lining a body cavity - KAPLOUN ILYA

0051] Proteolytic enzymes: Chymopapain, Chymotrypsin, Trypsin, Hyaluronidase. [0052] Antispasmodic: Oxybutynin, Papaverine. ...
more infohttp://www.freepatentsonline.com/y2004/0249364.html

DHG Pharmaceutical productsDHG Pharmaceutical products

Allicin (Garlic); Beta-Carotene; Chymopapain; L-Cystine; Methionine; Papain; Peroxidase; Pluriamin. Night Queen. Mimosa Pudica ...
more infohttps://drugs-about.com/firms/dhg-pharmaceutical.html

Intradiscal Lumbar PRP Injection - I have receivedIntradiscal Lumbar PRP Injection - I have received

Chymopapain (brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a ... 1.Rarely used technique involving injection of chymopapain into the nucleus pulposus of an intervertebral disc as a therapeutic ... medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, ... http://en.wikipedia.org/wiki/Chymopapain. __________________________________________________ __________________. Optum Encoder ...
more infohttps://www.aapc.com/memberarea/forums/printthread.php?t=85318

Chemonucleolysis failures treated by PLIF.Chemonucleolysis failures treated by PLIF.

Chymopapain / administration & dosage, therapeutic use*. Endopeptidases / therapeutic use*. Female. Humans. Intervertebral Disk ...
more infohttp://www.biomedsearch.com/nih/Chemonucleolysis-failures-treated-by-PLIF/3882299.html

How do you treat a bulging disc? | Reference.comHow do you treat a bulging disc? | Reference.com

Other surgical options include chymopapain injections and microendoscopic surgery.. Learn more about Conditions & Diseases ...
more infohttps://www.reference.com/health/treat-bulging-disc-5d4d39b8c85b25db

Cimetidine Hydrochloride Monograph for Professionals - Drugs.comCimetidine Hydrochloride Monograph for Professionals - Drugs.com

Chymodiactin (chymopapain for injection) prescribing information. Northbrook, IL; 1985 Jun.. 126. Deutsch PH. Dermatographism ...
more infohttps://www.drugs.com/monograph/cimetidine-hydrochloride.html

US5445606A - Indicator for iontophoresis system 
        - Google PatentsUS5445606A - Indicator for iontophoresis system - Google Patents

... chymopapain; cholecystokinin; chorionic gonadotropin; corticotropin (ACTH); erythropoietin; epoprostenol (platelet aggregation ...
more infohttps://patents.google.com/patent/US5445606
  • Another dangerous side effect of chymopapain injection is a severe allergic reaction called anaphylaxis. (drugs.com)
  • Before receiving chymopapain, you should discuss its use, and the possibility of anaphylaxis or other serious side effects, with your doctor. (drugs.com)
  • The following information includes only the average doses of chymopapain. (drugs.com)
  • Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
  • Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. (biochemj.org)
  • The environment of the catalytic site of chymopapain A is markedly different from those of other cysteine proteinases studied to date, as evidenced by the pH-dependence of the second-order rate constant (k) for the reaction of the catalytic-site thiol group with 2,2′-dipyridyl disulphide. (biochemj.org)
  • Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. (orcexperts.com)
  • Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve. (drugs.com)
  • One prominent Canadian orthopedic chymopapain advocate stated at a medical meeting that all he required was a "few cc's of chymopapain" to take care of all of his spine patients! (burtonreport.com)
  • The sad part of this tale is that the inadvertent deposition of chymopapain into nerve tissue as well as the sub-arachnoid space created some horrendous problems (including stroke, paraplegia, and death) for a significant number of patients. (burtonreport.com)
  • Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
  • Two spines, each of which consists of seven discs, were used for each of the following procedures: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. (biomedcentral.com)
  • A therapeutic concentration (2000 pKat/ml) of chymopapain stopped the microcirculation in the injected area immediately, with numerous microbleedings at the border zone. (lu.se)
  • The presence of other medical problems may affect the use of chymopapain. (drugs.com)
  • Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of medical devices and techniques even today. (burtonreport.com)
  • The striking bell-shaped component that is a characteristic feature of the reactions of S-/ImH+ (thiolate/imidazolium) ion-pair components of many cysteine-proteinase catalytic sites with the 2,2′-dipyridyl disulphide univalent cation is not present in the pH-k profile for the chymopapain A reaction. (biochemj.org)
  • significantly more nucleus is removed if chymopapain is used in addition to rongeurs. (biomedcentral.com)
  • Unfortunately the use of chymopapain created new problems for patients. (burtonreport.com)
  • The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing it decided to stop selling worldwide. (wikipedia.org)