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ChymopapainIntervertebral Disc ChemolysisFicainBromelainsPapainCystatins2,2'-DipyridylIntervertebral Disc DisplacementDrug Information ServicesCaricaSulfhydryl CompoundsBone Morphogenetic ProteinsPatents as TopicBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone and BonesBone Morphogenetic Protein Receptors, Type IAgaveNematode InfectionsAnthelminticsPyrantelTrichurisPeptidesMyelin Basic ProteinPeptide FragmentsManuscripts as TopicAmino Acid SequenceMolecular Sequence DataHLA-DR2 Antigen
Chymopapain: A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.Intervertebral Disc Chemolysis: The dissolving of the nucleus pulposus, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.Ficain: A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is at tyrosine and phenylalanine residues. EC 3.4.22.3.Bromelains: Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.Papain: A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.Cystatins: A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.2,2'-Dipyridyl: A reagent used for the determination of iron.Intervertebral Disc Displacement: An INTERVERTEBRAL DISC in which the nucleus pulposus has protruded through surrounding fibrocartilage. This occurs most frequently in the lower lumbar region.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Carica: A plant genus of the family Caricaceae, order Violales, subclass Dilleniidae, class Magnoliopsida. It is the source of edible fruit and PAPAIN.Sulfhydryl Compounds: Compounds containing the -SH radical.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Morphogenetic Protein Receptors, Type I: A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.Agave: A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.Nematode Infections: Infections by nematodes, general or unspecified.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Pyrantel: A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)Trichuris: A genus of nematode worms comprising the whipworms.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Myelin Basic Protein: An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.HLA-DR2 Antigen: A broad specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*01:15 and DRB1*01:16 alleles.

Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (1/37)

Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells.  (+info)

Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. (2/37)

This single-blind randomised clinical trial compared osteopathic manipulative treatment with chemonucleolysis (used as a control of known efficacy) for symptomatic lumbar disc herniation. Forty patients with sciatica due to this diagnosis (confirmed by imaging) were treated either by chemonucleolysis or manipulation. Outcomes (leg pain, back pain and self-reported disability) were measured at 2 weeks, 6 weeks and 12 months. The mean values for all outcomes improved in both groups. By 12 months, there was no statistically significant difference in outcome between the treatments, but manipulation produced a statistically significant greater improvement for back pain and disability in the first few weeks. A similar number from both groups required additional orthopaedic intervention; there were no serious complications. Crude cost analysis suggested an overall financial advantage from manipulation. Because osteopathic manipulation produced a 12-month outcome that was equivalent to chemonucleolysis, it can be considered as an option for the treatment of symptomatic lumbar disc herniation, at least in the absence of clear indications for surgery. Further study into the value of manipulation at a more acute stage is warranted.  (+info)

Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental study. (3/37)

Although chemonucleolysis with chymopapain is a long-established treatment for lumbar intervertebral disc herniation, serious complications have been reported. Accordingly, alternative substances for chemonucleolysis have been sought. The main beneficial effect of chemonucleolysis derives from the decrease in intradiscal pressure. Several previous studies have investigated the relationship between physiological saline injection and disc mechanics in cadaveric specimens [2, 5, 16]. However, no previous study has assessed the intradiscal pressure after intradiscal injection of "hypertonic saline" in living animals. The present study compared the changes in intradiscal pressure after intradiscal injection of hypertonic saline with those after chymopapain injection. The lumbar intervertebral discs of 26 living rabbits were examined: 10% hypertonic saline was injected in ten rabbits, and chymopapain (10 pikokatal units) was injected intradiscally in another ten, with the remaining six being used as controls. The intradiscal pressure was measured at 1, 4, and 12 weeks after injection. The intradiscal pressure of the hypertonic saline-injected group at 4 weeks was significantly lower than that of the control group, but by 12 weeks it had recovered. On the other hand, that of the chymopapain-injected group remained significantly lower than that of the control group at 12 weeks. The results of this study found that hypertonic saline injected into the intervertebral discs temporarily decreased the intradiscal pressure.  (+info)

Chemonucleolysis: the state of the art. (4/37)

This review presents the history of chemonucleolysis, the techniques, indications, contraindications, and complications. Presenting an historical overview and comparison of success rates with surgical discectomy may provide a fresh understanding of the controversy surrounding chemonucleolysis and establish its efficacy in relation to more invasive treatments. A review of the literature from 1973 through 1998 for chemonucleolysis, open discectomy, and microdiscectomy provided published success rates for these procedures, and a mean rate with standard deviation was determined. In the experience and opinion of the authors, chemonucleolysis remains a viable alternative for patients who have exhausted all conservative means of treatment. Proper patient selection leads to success rates comparable to open discectomy and microdiscectomy.  (+info)

Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water. (5/37)

BACKGROUND: This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI) of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. RESULTS: The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. CONCLUSION: The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn.H2O.Sn) of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.  (+info)

The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. (6/37)

OBJECTIVE: The purpose of this work was to test the effect of inhibition of bone remodeling, through the use of the bisphosphonate, zoledronic acid, on cartilage matrix damage in an animal model of cartilage matrix damage. DESIGN: New Zealand white rabbits were divided into four groups for treatment purposes: (1) untreated controls; (2) injected into one knee joint with the cartilage matrix degradation enzyme, chymopapain; (3) injected into one knee joint with chymopapain and also given subcutaneous injections of the bisphosphonate, zoledronic acid, three times per week until sacrifice at either day 28 or 56 post-chymopapain-injection; (4) received only the zoledronic acid injections. At sacrifice, the knee joints were examined grossly and histologically, and biochemically for proteoglycan content. Urine samples were analysed, at intervals, for levels of collagen cross-links which are biochemical markers of cartilage and bone. RESULTS: Animals receiving both intraarticular chymopapain injections and subcutaneous zoledronic acid injections displayed a significantly lower degree of grossly and histologically detectable cartilage degeneration on the tibial articular surfaces (the articular surface displaying the greatest degree of degeneration) than did animals only receiving the chymopapain injections. In addition, urinary levels of collagen cross-links for bone and cartilage were significantly higher in those animals only receiving chymopapain injections. CONCLUSION: The bone resorption observed after chymopapain injection into the rabbit knee joint can be inhibited through the use of the bisphosphonate, zoledronic acid. Furthermore, zoledronic acid does not increase the level of cartilage degeneration and appears to provide some level of chondroprotection in this model.  (+info)

Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. (7/37)

OBJECTIVE: To determine if oral glucosamine (GlcN) improves joint biology after acute damage by a protease. METHODS: The effect of 8 weeks of dietary GlcN (20 or 100 mg/kg/day) on knee joint cartilage was evaluated in 2.2-kg male NZW rabbits with and without damage introduced by intraarticular injection of chymopapain (CP). Cartilage was evaluated histologically and scored according to the Mankin scale. Analyses of total hydroxyproline and glycosaminoglycan (GAG) contents and reverse transcription-polymerase chain reaction (RT-PCR) analysis of selected genes were performed. RESULTS: After 8 weeks, there was no effect of GlcN on the GAG content of normal cartilage. Both levels of GlcN treatment significantly increased the sulfated GAG content in the cartilage of the medial femoral condyle in damaged and contralateral knees, but did not change the collagen content. In CP-injected knees, there was still some loss of surface proteoglycan (PG) that was not completely corrected by dietary GlcN. Even after 8 weeks, levels of messenger RNA (mRNA) detected by RT-PCR showed changes indicative of damage and repair, such as elevated type II collagen mRNA, and these levels were not influenced by GlcN treatment. Meniscal GAG content was increased in the contralateral knee of rabbits receiving high-dose GlcN, but was decreased in those receiving no GlcN or low-dose GlcN. Neither diet nor treatment affected the meniscal collagen content. CONCLUSION: These results suggest that oral GlcN treatment might be useful in a situation where GlcN is limiting, such as where there is a rapid replacement of cartilage PG.  (+info)

Chemonucleolysis. (8/37)

A prospective study of 480 patients who underwent enzymatic dissolution of the nucleus pulposus with chymopapain is reported. Seventy per cent of patients with the clincial criteria for a disc herniation had a favourable response to chemonucleolysis. The commonest cause of failure was persistent back pain. In patients with sequestered discs or lateral recess stenosis surgical intervention was not made more difficult by chemonucleolysis. Those with a previous operation, spinal stenosis or psychogenic components to the disability had very poor results. Complications were few and easily managed.  (+info)

Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...
Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and significantly lower than those of papain or ficin. The environment of the ...
Chymopapain Injection Advanced Patient Information - Drugs.comChymopapain Injection Advanced Patient Information - Drugs.com
Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
discogel.com.ardiscogel.com.ar
ment of back pain; it consists of a percutaneous intradiskal ment of the disk, we performed a concomitant injection of intra- injection that dissolves the nucleus pulposus and lowers in- articular steroids in the adjacent facet joints in all patients.9 tradiskal pressure. Several years ago, the most widely used sub- Procedures were performed with local anesthetic, under surgical stance for this was chymopapain, which had an efficacy of conditions and controlled digital fluoroscopy. A diskography was close to 80% in lumbar disk herniations and close to 85% in performed before RGE nucleolysis. The dose of RGE injected into the cervical disk hernias1-3 but was withdrawn from the market cervical disk was 0.2- 0.3 mL. Intradiskal injection of 1-2 mg of gen- due, in part, to anaphylactic reactions to this enzyme.4 After tamicin was systematically performed in all the cases at the end of the this, the search for a new drug that could have the same effi- procedure to prevent infection. At least 1 facet ...
Rongeurs & Spinal InstrumentsRongeurs & Spinal Instruments
We carry a limited range of rongeurs and spinal instruments following requests from veterinary surgeons, however our supplier carries a full range of instruments within this field so if you need something we dont list just ask and we give you a quote. Similarly if you have an idea for a new instrument or modification of an existing instrument we would be very keen to help make your idea reality. ...
Compléments morphologiques à létude de quelques Nématodes Héligmosomes, parasites de Rongeurs américains | ParasiteCompléments morphologiques à l'étude de quelques Nématodes Héligmosomes, parasites de Rongeurs américains | Parasite
Parasite international open-access, peer-reviewed, online journal publishing high quality papers on all aspects of human and animal parasitology
Carica PapayaCarica Papaya
Salutary effects of carica papaya leaf extract in dengue fever patients- a pilot study... Salutary effects of carica papaya leaf extract in dengue fever patients- a pilot study.. Thrombocytosis and anti-inflammatory properties, and toxicological evaluation of carica papaya mature leaf concentrate in a murine model... A study of haemato-stimulatory effects of graded dose of aqueous carica papaya seed extract in wistar rats... Dengue fever treatment with carica papaya leaves extracts... Carica papaya leaves juice significantly accelerates the rate of increase in platelet count among patients with dengue fever and dengue haemorrhagic fever... The effect of carica papaya l. Leaves extract capsules on platelets count and hematocrit level in dengue fever patient... Evaluation of platelet augmentation activity of carica papaya leaf aqueous extract in rats.. ...
Papain Market Sees a Steady Growth Ahead - BizPR.ca | Canadian Free Press Release and Distribution CentrePapain Market Sees a Steady Growth Ahead - BizPR.ca | Canadian Free Press Release and Distribution Centre
Papain is also known as papaya proteinase-I which is an enzyme present in papaya. Papain is an important digestive enzyme which breakdown tough protein fibers. Papain is very stable also at very elevated temperatures. Papain latex is a rich source of cysteine endopeptidases including chymopapain, caricain and glycyl endopeptidase. Papain is traditionally used as a meat tenderizer and also used in skin burns, skin ulcers, wounds etc. Some of the common uses of papain are it boosts digestion, treats skin and wound, resistant to fungus, supports immune system and source of antioxidant etc. As papain is source of antioxidant, it is commonly used in food preservation to reduce bacterial infestations and spoilage of food due to oxidation.. Market Segmentation: Papain. The Papain market is segmented on the basis of its applications in different industries like food industry, cosmetic industry, pharmaceutical industry and chemical industry etc. Papain is used for food industry for food processing, as a ...
Avita Pharmacy - Wellness LibraryAvita Pharmacy - Wellness Library
Papaya is likely safe when consumed in food amounts. Fermented papaya is possibly safe when used medicinally for up to three months. Use with caution in patients with bleeding disorders or those taking agents that may increase the risk of bleeding, in patients with diabetes or hypoglycemia or those taking agents that affect blood sugar, and in patients with autoimmune disorders or those using agents that affect the immune system. Use papaya seed extract and the papaya enzyme papain with caution. Use cautiously with vitamin A or retinoids, beta-carotene or carotene-containing foods, iron or iron-rich foods, sodium, potassium supplements, or agents that alter potassium levels. Avoid in patients with a known allergy or hypersensitivity to papaya, its components (including papaya juice, papaya flower pollen, papain, and chymopapain), members of the Caricaceae family, or latex. Cross sensitivity between kiwi and papaya, as well as papain, has been reported. Severe life-threatening allergic reactions ...
Full Endoscopic Spinal Surgery Techniques: Advancements, Indications, and Outcomes | EndoscopesFull Endoscopic Spinal Surgery Techniques: Advancements, Indications, and Outcomes | Endoscopes
In the early 1960s, Lyman Smith injected chymopapain into a herniated lumbar disc using what was later to be termed "the safe zone" by Kambin and thus began the era of minimally invasive spine surgery.29 The first meeting of the International Society for Minimal Intervention of Spine Surgery in April 1990 further defined the term minimally invasive spine surgery against the back drop of the additional advances that had been made in endoscopic spine surgery techniques and approaches.. Endoscopic spinal surgery clinical outcomes have been studied for the past 25 years. These outcomes have included prospective randomized clinical trials evaluating the effectiveness of endoscopic techniques versus open posterior microdiscectomy techniques in the treatment of primary and revision lumbar disc herniations.1,30-34 These trials have revealed equivalency in outcomes amongst the two treatment groups. Recent non-randomized lumbar studies include a single surgeon evaluation of 400 patients using the ...
Antimicrobial and anti-inflammatory activity of aqueous extract of Carica papaya | JHPAntimicrobial and anti-inflammatory activity of aqueous extract of Carica papaya | JHP
Introduction: Over centuries, Carica papaya (papaya) has been used as a nutritious and medicinal plant. In view of its medicinal uses, our group focused on aqueous leaves extract of papaya and tried to determine its antimicrobial (using bacterial strains i.e. gram positive and gram negative ones) and anti-inflammatory (virally infected human whole blood) activities. The protein content of the plant and its secondary metabolites were also analysed qualitatively.Methods: The protein content from aqueous leaves extract of C. papaya was quantified using Nanodrop method. ELISA studies were conducted in order to determine the antibody production against ovalbumin (OVA) using papaya aqueous leaves extract. Also, its antigen specific proliferation in virally infected human whole blood samples was determined through MTT assay. In addition, antimicrobial studies (using gram positive and gram negative strains) and cytotoxicity were also studied.Results: The aqueous leaves extract of papaya showed enhancement in
Dwarf Papaya Tainung (Carica papaya): 4: Pot: LogeesDwarf Papaya Tainung (Carica papaya): 4: Pot: Logee's
Papaya Tainung (Carica papaya), a red commercial variety, is deliciously sweet & produces abundant fruits that weigh from 3 to 5 pounds. Excellent for pots.
Carica papaya - WikispeciesCarica papaya - Wikispecies
Hassler, M. 2019. Carica papaya. World Plants: Synonymic Checklists of the Vascular Plants of the World (2019). In: Roskov Y., Abucay L., Orrell T., Nicolson D., Bailly N., Kirk P., Bourgoin T., DeWalt R.E., Decock W., De Wever A., Nieukerken E. van, Zarucchi, J., Penev L., eds. 2019. Species 2000 & ITIS Catalogue of Life. Published on the internet. Accessed: 2019 Aug. 30 ...
Carica papaya | BartlebyCarica papaya | Bartleby
Free Essays from Bartleby | Effect of Carica papaya seed extract on the cell wall of A. flavus under transmission electron microscope: In this experiment,...
PD Stock photo : Toucan (Ramphastidae), In A Carica Papaya Eating Its Juicy FruitPD Stock photo : Toucan (Ramphastidae), In A Carica Papaya Eating Its Juicy Fruit
Buy or license direct from the photographer this stunning image of : Toucan (Ramphastidae), In A Carica Papaya Eating Its Juicy Fruit
Curved Foraminotomy Rongeurs | Medline Industries, Inc.Curved Foraminotomy Rongeurs | Medline Industries, Inc.
Due to the coronavirus outbreak worldwide, global demand for some personal protective equipment (PPE) is exceeding supply. In addition, manufacturing of PPE and many other wound care and infection prevention products have been impacted by global response to coronavirus. While you may see product availability reduction in the near-term, please be assured Medline continues to work to diversify production and provide your supply needs. As always, please reach out to your Medline sales representative with any specific questions or follow up. ...
Un Isothrix nouveau de Bolivie (Rongeurs, Echimyidés). La denture des Isothrix : MammaliaUn Isothrix nouveau de Bolivie (Rongeurs, Echimyidés). La denture des Isothrix : Mammalia
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1MM KERRISON RONGEURS 8″ UPWARD WITH BLACK COATING G.S INSTRUMENTS - Medical Supply1MM KERRISON RONGEURS 8″ UPWARD WITH BLACK COATING G.S INSTRUMENTS - Medical Supply
Medical Supply Exchange / medsupplyexchange.com We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. For all other advertisement and cookie disclosures, please view our full Privacy & Cookie Policy.. ...
Papaya Leaf Powder or Cut and Sifted - Carica papayaPapaya Leaf Powder or Cut and Sifted - Carica papaya
Superior quality bulk Papaya Leaf available from Starwest - offering the finest chinese, craft, culinary, and therapeutic herbs since 1975.
Conteggio delle piastrine dellestratto e della foglia della papaiaConteggio delle piastrine dell'estratto e della foglia della papaia
La papaia o lasimina (Carica papaya) è una frutta tropicale, che è stata associata coerente con i numerosi beni medicinali. Uno degli la più importanti di questi reclami è la capacità dellestratto
Eat a Slice of Papaya Every Day for These BenefitsEat a Slice of Papaya Every Day for These Benefits
The benefits of papaya are both internal and external because in addition to improving your digestion and strengthening your immune system, papaya also helps to prevent cellular damage ...
Patent search - Patent Attorneys - Patent Applications - Patent SalePatent search - Patent Attorneys - Patent Applications - Patent Sale
Sustained-release formulation containing and amino acid polymer | vitamin D.sub.3 derivatives having a substituent at 2-position | In cap medication reminder | Morpholine derivatives, compositions and method of use | Pharmaceutical compositions and methods for increasing zinc levels |
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Detoxify Your Kidneys, Liver and Digestive System - All You Need Is Papaya Seeds! - Healthy Food StarDetoxify Your Kidneys, Liver and Digestive System - All You Need Is Papaya Seeds! - Healthy Food Star
The normal usage of papaya seeds is 1 tbsp. of them. This dosage is enough to get rid of the all toxins in the liver. Researches proved that these seeds prevent cirrhosis. Consume 5 papaya seeds, two times on a daily basis for 30 days continuously.. Or, you can grind them, crush them if the seeds are fresh in a mortar, and then add them to a refreshing lime juice. Drink this treatment twice per day for 30 days.. Promote Digestive Wellness. Papaya is ideal for digestion, and papaya seeds are rich in potent anti-parasite and antibacterial properties which remove the hazardous microorganisms in the intestinal tract. Moreover, papaya provides powerful anti-pathogenic properties that prove you need to eat 1 tbsp. of these seeds to prevent food poisoning and to eliminate bacteria that provoke digestion problems.. Reduce Swelling in Inflammatory Diseases. Papaya consists of 2 amazing enzymes, papain and chymopapain, which due to their powerful anti-inflammatory properties, they soothe swelling in case ...
Papaya Leaf JuicePapaya Leaf Juice
... aids in the breakdown and metabolism of protein, exhibits anti-ulcer activity and helps to relieve indigestion. Papaya leaf contains the powerful proteolytic enzymes, papain and chymopapain, which digest proteins, small peptides, amides and esters. Their activity extends to carbohydrate and fat, and they are said to be more effective than naturally- occurring proteases like pepsin and trypsin. Since stomach ailments are often the direct result of indigestion, papaya leaf juice may help prevent and remedy these by increasing digestive processes, as the digestive properties of papain are well established ...
Buy carica papaya - 0.5 kg seeds online at Nursery Live | Best seeds at lowest priceBuy carica papaya - 0.5 kg seeds online at Nursery Live | Best seeds at lowest price
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Carica papayaCarica papaya
Owoyele, Bamidele V., Adebukola, Olubori M., Funmilayo, Adeoye A, Soladoye, Aydoele O. 2008. Anti-inflammatory activities of ethanolic extract of Carica papaya Leaves. Inflammopharmacology 16 (2008) 168-173.. Papaya 2002. ,URL: http://www.herbs2000.com/herbs/herbs_papaya.htm, Accessed 28 March 2011. Papaya 2011. ,URL: http://www.hort.purdue.edu/newcrop/morton/papaya_ars.html#Origin%20and%20D istribution, Accessed 28 March 2011. Papayas. ,URL: http://www.innvista.com/health/foods/fruits/papayas.htm,. Accessed March 23rd 2011. Papaya Nutritional Information and Facts 2005. ,URL: http://www.juicing-for- health.com/papaya.html, Accessed 28 March 2011.. Phylum Magnoliophyta. ,URL: http://people.uvawise.edu/swvaflora/Magnoliophyta.html,. Accessed March 12th 2011.. ...
Papaya orchard, Carica papaya, with fruit - Stock Image E768/0165 - Science Photo LibraryPapaya orchard, Carica papaya, with fruit - Stock Image E768/0165 - Science Photo Library
Papaya orchard. Fruit growing on papaya trees, Carica papaya, in an orchard. Papaya is also known as the common pawpaw. The tree produces large, spherical fruit which may be eaten at breakfast, in salads or for dessert. Papaya leaves can be wrapped around meat when it is cooked. While it is known that papaya trees are native to the New World, their exact origin is uncertain. Photographed in Hawaii, USA. - Stock Image E768/0165
Papaya (Carica papaya L.) | CCRCPapaya (Carica papaya L.) | CCRC
Carica papaya L. is a scrub like a tree with the upright stalk and round. The top can be branch or not, side of that like a spons and hollow, in the outside a lot of leaf scars. The height of the tree around 2,5-10 m, petiole hollow round, the length around 2,5-10 m, round leaf or oval, bone of the leaves are finger shape, serrated edge, sharing such as finger, pointed tip with diameter around 25-75 cm, the top is green, the bottom is light green, slippery, and gloomy, each of three circle stalk trere are 8 leaves. The flowers almost always unisexual or dioecious, but mostly with several hermaphrodite flower in the staminate bouquet. The staminate in the bunches that same with tassel and long stalk, very small petals, the crown like a cream trumpet, with five edge, and long tube, slim, spin edge in the bud, anthers short stemmed, and the pistillate mostly stand-alone, the crown leaves loose and almost loose, cream, ovary tipped one, anthers are five. This plant can be found almost in the whole ...
Rare Unusual Plants | Canna Lily Phasion variegated & Stuttgart sport & Carica papaya Sunrise & patens & indica red and gold...Rare Unusual Plants | Canna Lily Phasion variegated & Stuttgart sport & Carica papaya Sunrise & patens & indica red and gold...
Buy Canna Lily Phasion variegated, Stuttgart sport, Carica papaya Sunrise, patens, indica red and gold indian shot, Florence Vaughn, Cassia, and alata Empress Candelabra
carica papaya rich enzyme tablets : BioShope in Chennai, Indiacarica papaya rich enzyme tablets : BioShope in Chennai, India
More about carica papaya rich enzyme tablets : By BioShope in Chennai, India; Contact Number, Address, Ratings, Location of the business, and more;
SCresearch.orgSCresearch.org
This is a clinical study looking at the effectiveness and safety of a new device call The Paradise System to use for renal denervation in patients who have mild to resistant hypertension. The study is divided into two groups, those on one to two anti hypertensive medications and those on three or more. For those only taking one or two medications, they will stop their current blood pressure medication while monitoring their blood pressure. Those who are taking 3 or more blood pressure medications will stop their current medication regime and be given one of two combination medications while monitoring their blood pressure. In each of the groups have the patients, if and when they continue to meet study inclusion criteria, will be randomized to undergo a renal denervation procedure using the new system vs no procedure. Their assignment will not be made known to them. All groups will be follow up to 3 years but for patients who did not initially have the procedure will be allowed to do so after ...
Papaya (Carica papaya) - OPWRPapaya (Carica papaya) - OPWR
The papaya tree is one of the most distinctive plants on earth. It is generally 4 to 5 meters tall and unbranched, but old plants may be 10 meters tall. The trunk looks a little like an upside-down, gray carrot. This plant has huge leaves with very long petioles and are clustered near the top of the tree, because the lower ones are shed, leaving large, circular scars on the bark. The stem is soft and weak because it has very flimsy wood (secondary xylem) and a hollow center. Once a plant starts to produce, there is a continuous supply of fruits. All one has to do is to climbing to harvest the lowermost papaya fruit.. The ripe fruit has a yellow and green skin, often with tints of red and orange, and a sweet, semi-firm, yellow-orange pulp. Within the central cavity of the fruit are hundreds of dark seeds that almost appear bluish when the fruit is cut open; they are about the size of small peas and are attached to the pulp. Papaya fruit is most commonly eaten fresh for dessert or made into a ...
500 Papaya Fruit Seeds CARICA papaya500 Papaya Fruit Seeds CARICA papaya
The large oval fruits of this "Melon tree" are attached in clusters just under its umbrella of snowflake shaped leaves. Tropical. Makes a very handsome indoor ornamental tree if you provide sufficient warmth and bright light. With ideal conditions will bear fruit in 1 year. Self pollinating. Mature hgt. 18'-25' Growing Instructions & Tips: Plant at 1/2" depth using well draining soil mixture. Keep warm and damp - not wet. Requires bright light. Fertilize every two weeks.
Papaya Benefits, Papaya Fruit Uses, Green Papaya Suppliers, ExportersPapaya Benefits, Papaya Fruit Uses, Green Papaya Suppliers, Exporters
Papaya - Get complete information on papaya fruit, green papaya, papaya tree, papaya plants, fresh papaya uses, health benefits of papaya fruits and papaya suppliers, green papaya exporters from India.
Insects That Eat Papaya Plants in Florida | Garden GuidesInsects That Eat Papaya Plants in Florida | Garden Guides
Papaya plants (Carica papaya), commonly referred to as trees, are actually very large herbaceous perennials, usually with a short life span (but capable of living up to 20 years). Papayas produce large fruit with very sweet, yellow to red-orange-colored flesh. They are not difficult to grow when given a site with ...
Smith Peterson Laminectomy Rongeur 9 1/2 - 40-4110 - Each - Surgical Instruments - OrthopedicSmith Peterson Laminectomy Rongeur 9 1/2' - 40-4110 - Each - Surgical Instruments - Orthopedic
We offer discount medical surgical supplies and instruments in the Orthopedic Rongeurs category, such as the Smith Peterson Laminectomy Rongeur 9 1/2 40-4110
Oleh Rindia Maharani Putri - ppt downloadOleh Rindia Maharani Putri - ppt download
Agenda Presentasi Pendahuluan Aspek Bioteknologi Struktur Papain Teori mengenai Papain Isolasi dan Karakterisasi Papain dari Pepaya (Carica papaya)
Catalogue: Fresh Carica Dieng | ITPC MilanCatalogue: Fresh Carica Dieng | ITPC Milan
What is Carica? It is is a type of papaya fruit, often called mountain papaya and it contains many beneficial vitamins. What are interesting and unique from
переводная головка | corona di caricaпереводная головка | corona di carica
(KudoZ) Russian to Italian translation of переводная головка: corona di carica [orologi - Mechanics / Mech Engineering (Tech/Engineering)].
One Piece879: Katakuri, uno dei tre Dolci Comandanti di Big Mom pagina 1 (Carica immagini: 3) - Italiano manga - Nine MangaOne Piece879: Katakuri, uno dei tre Dolci Comandanti di Big Mom pagina 1 (Carica immagini: 3) - Italiano manga - Nine Manga
One Piece879: Katakuri, uno dei tre Dolci Comandanti di Big Mom pagina 1 (Carica immagini: 3), One Piece Manga italiano, read One Piece891 on-line
One Piece785.5: Anche se le vostre gambe dovessero spezzarsi (Digital Colored) pagina 1 (Carica immagini: 3) - Italiano manga -...One Piece785.5: Anche se le vostre gambe dovessero spezzarsi (Digital Colored) pagina 1 (Carica immagini: 3) - Italiano manga -...
One Piece785.5: Anche se le vostre gambe dovessero spezzarsi (Digital Colored) pagina 1 (Carica immagini: 3), One Piece Manga italiano, read One Piece891 on-line
What is benefits of papaya for health?What is benefits of papaya for health?
... - There are 2 main papaya varieties: Mexican, which may weigh the maximum amount as ten pounds, and also the a lot of…
13 Side Effects Of Papaya13 Side Effects Of Papaya
The juicy yellow papaya is fully loaded with nutrients and has a rich source of dietary fiber. Here we have also listed a few side effects of papaya. ReadOn
Suport Taufiq R. Abdullah Untuk Petani Carica | PKBTVSuport Taufiq R. Abdullah Untuk Petani Carica | PKBTV
Anggotaa DPR RI dari Fraksi Partai Kebangkitan Bangsa (PKB) Drs. H. Taufiq R. Abdullah mendesak kepada pemerintah agar bersungguh-sungguh memberikan dukungan untuk pengembangan hasil pertanian khas Ba
ARCONA Papaya Enzyme Gel | Buy Online At SkinCareRXARCONA Papaya Enzyme Gel | Buy Online At SkinCareRX
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Eat a Slice of Papaya Every Day for These Benefits - Step To HealthEat a Slice of Papaya Every Day for These Benefits - Step To Health
Todays article talks about the many beneficial properties you can get from eating just a slice of papaya every day. Dont miss it!
pom212 papaya and guava 2005 handout - Papaya Carica papaya • Fleshy berry • Also known as pawpaw • Cultivars vary in shape and...pom212 papaya and guava 2005 handout - Papaya Carica papaya • Fleshy berry • Also known as pawpaw • Cultivars vary in shape and...
View Notes - pom212_papaya_and_guava_2005_handout from POM 212 at UC Davis. Papaya Carica papaya • Fleshy berry • Also known as pawpaw • Cultivars vary in shape and size - Elongated to
Molecules | Free Full-Text | Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats...Molecules | Free Full-Text | Repeated Dose 28-Days Oral Toxicity Study of Carica papaya L. Leaf Extract in Sprague Dawley Rats...
Carica papaya L. leaves have been used in ethnomedicine for the treatment of fevers and cancers. Despite its benefits, very few studies on their potential toxicity have been described. The aim of the present study was to characterize the chemical composition of the leaf extract from Sekaki C. papaya cultivar by UPLC-TripleTOF-ESI-MS and to investigate the sub-acute oral toxicity in Sprague Dawley rats at doses of 0.01, 0.14 and 2 g/kg by examining the general behavior, clinical signs, hematological parameters, serum biochemistry and histopathology changes. A total of twelve compounds consisting of one piperidine alkaloid, two organic acids, six malic acid derivatives, and four flavonol glycosides were characterized or tentatively identified in the C. papaya leaf extract. In the sub-acute study, the C. papaya extract did not cause mortality nor were treatment-related changes in body weight, food intake, water level, and hematological parameters observed between treatment and control groups. Some
Sciatica due to a herniated disc-healing your aching backSciatica due to a herniated disc-healing your aching back
Dr. Steve Shoshany is a new breed of New York Chiropractor. As a New York Chiropractor, Dr. Shoshany has many interesting experiences. This New York Chiropractor blog is a journal of the day to day happenings of a New York Chiropractor and his New York Chiropractor clinic.Using the exclusive DRX 9000 he shares his results with this Non Surgical Spinal Decompression with all that are interested.This is an excellent treatment for those with a herniated disc and back pain. ...
ELISA Kit-Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests-Alpha Diagnostic...ELISA Kit-Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests-Alpha Diagnostic...
Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests ELISA Kit 800-160-CPP Carica papaya Papain ELISA kit (for measuring papain residue/contaminant in therapeutics), 96 tests ELISA Kit 800-160-CPP
Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats | BMC Complementary and Alternative...Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats | BMC Complementary and Alternative...
Our results show that the intraperitoneal administration of STZ to rats significantly increased glucose blood levels four days after injection, as well as decreased body weight. In addition, other diabetes-related signs were observed. These results agree with previous observations that have employed this model and that also report loss of body weight [13, 14].. Several reports suggest that this model of type 1 diabetes induced by STZ is adequate to evaluate the properties of leaves or fruits from different plants [15-17]. In the present study, the aqueous extract of C. papaya maintained the body weight of diabetic rats during treatment. Weight loss is a main sign of diabetes but its mechanism is not clear. It could be due to many factors such as loss of appetite, increased muscle waste and loss of tissue proteins [15, 18, 19]. In addition, the administration of the aqueous extract of C. papaya decreased water consumption. Other natural products also produce a decrease in both water intake and ...
Injection Therapy - Professional course - UWE Bristol: CoursesInjection Therapy - Professional course - UWE Bristol: Courses
In the Injection Therapy course, study the theoretical and practical principles of injection therapy for musculoskeletal conditions.
subject:(Cardioprotection) - OATDsubject:(Cardioprotection) - OATD
La suralimentation postnatale (SAPN) chez les rongeurs induit des modifications cardio-métaboliques à lâge adulte. Notre objectif a été de déterminer si une restriction calorique (RC) modérée pouvait restaurer ces altérations cardio-métaboliques et améliorer la récupération post-ischémique dans un modèle de cœur perfusé in vitro.Après la naissance, des souriceaux C57BL/6 ont été répartis au nombre de 9 par portée pour les groupes témoins (Normoalimentées: NA), ou au 3 par portée pour induire la SAPN. Après le sevrage, les souris ont eu un accès libre à une nourriture standard et à leau. A 6 mois, la moitié des souris des deux groupes a été soumise à une RC de 20% (NARC, SARC) pendant un mois, tandis que lautre moitié a continué à se nourrir ad libitum (NAAL, SAAL). Des paramètres métaboliques et de la fonction cardiaque ont été évalués avant et après RC. A 7 mois, nous avons évalué au niveau du myocarde la sensibilité aux lésions ...
Intradiscal Electrothermal Therapy | Martin Castillo DPTIntradiscal Electrothermal Therapy | Martin Castillo DPT
Intradiscal electrothermal therapy (IDET) is a minimally invasive procedure for treating lower-back pain caused by worn spinal discs. IDET uses a heating device on the affected disc; the heat that it generates destroys nerve fibers, toughens the disc
Mother & Baby Care - GreenBeautyKokoMother & Baby Care - GreenBeautyKoko
id":422596706315,"title":"Organic Island Paw Paw Lip Salve 25ml","handle":"organic-island-paw-paw-lip-salve-25ml","description":"\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eDiscover the power of Paw Paw More!\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=ltr\u003e\u003cspan\u003eScientifically formulated to protect, replenish and nourish skin while maintaining hydration. The \u003c\/span\u003e\u003cspan\u003ePaw Paw Lip Salve\u003c\/span\u003e\u003cspan\u003e uses three types of paw paw enzymes, including NOP Organic Dehydrasome Pumpkin Papaya™, Papain (Papaya Enzyme) \u0026amp; Carica Papaya Fruit Extract (Paw Paw) to create a uniquely powerful formula that effectively moisturises and soothes all year round. Technologically advanced delivery systems OliveM1000 Crystal Skin and Si02 Matrix™ help to readily absorb these high quality organic ingredients directly into your skin, ensuring fast results you can see and feel. ...
JCDR - Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced...JCDR - Efficacy of Carica Papaya Leaf Extract in Reducing Treatment-Delay Secondary to Chemotherapy induced...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Definition for caricaDefinition for carica
carica definition: the nature genus for the Caricaceae; consisting of tropical United states trees; the papayas.; A genus of plants, normal order Papayaceæ, consisting of about 20 types, that are natives…
NAC & other cysteine sources to be avoided by Cancer Pts - INTERESTING TIMES - LiveJournalNAC & other cysteine sources to be avoided by Cancer Pts - INTERESTING TIMES - LiveJournal
NAC GOOD FOR ** **URIs particularly useful for treating upper respiratory and lung infections; mucolytic classic study published in 1997: may not even notice being sick NAC significantly reduced flu-like episodes **OCD case report of a single patient with OCD who benefited from taking NAC was…
Are Papayas Bad For You? - Here Is Your Answer.Are Papayas Bad For You? - Here Is Your Answer.
Approved by Dr. Sunil - Papaya is very healthy for you unless you are pregnant, in which case you would want to limit your consumption. The powerful nutrients in this fruit support many vital organs and systems throughout the body. Not only is papaya great for the internal body it has many benefits for the skin.
Know the Benefits of Drinking Papaya Juice | HubPagesKnow the Benefits of Drinking Papaya Juice | HubPages
know the benefits of drinking papaya juice in treating weight loss, diabetes, heart diseases, acne and much more. Papaya juice is one of the most healthy and nutritious juices, a must for you all
CaricainCaricain
Glycyl endopeptidaseGlycyl endopeptidase
Parviz KambinParviz Kambin
Crotalidae polyvalent immune fabCrotalidae polyvalent immune fab
FicainFicain
List of MeSH codes (D08)List of MeSH codes (D08)
List of drugs: Cf-ChList of drugs: Cf-Ch
ATC code M09ATC code M09
List of EC numbers (EC 3)List of EC numbers (EC 3)
ChymopapainChymopapain
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
ChymopapainIntervertebral Disc ChemolysisFicainBromelainsPapainCystatins2,2'-DipyridylIntervertebral Disc DisplacementDrug Information ServicesCaricaSulfhydryl CompoundsBone Morphogenetic ProteinsPatents as TopicBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone and BonesBone Morphogenetic Protein Receptors, Type IAgaveNematode InfectionsAnthelminticsPyrantelTrichurisPeptidesMyelin Basic ProteinPeptide FragmentsManuscripts as TopicAmino Acid SequenceMolecular Sequence DataHLA-DR2 Antigen
Chymopapain Injection Advanced Patient Information - Drugs.comChymopapain Injection Advanced Patient Information - Drugs.com
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...
Chymopapain - WikipediaChymopapain - Wikipedia
Chymopapain (Injection Route) Proper Use - Mayo ClinicChymopapain (Injection Route) Proper Use - Mayo Clinic
chymopapain from papaya latex Global Market and Forecast Research : ReportsnReportschymopapain from papaya latex Global Market and Forecast Research : ReportsnReports
Federal Register :: Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...Federal Register :: Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...
Microvascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbitsMicrovascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbits
The Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton ReportThe Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton Report
Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...
Chymopapain Expert for Consulting, Expert WitnessChymopapain Expert for Consulting, Expert Witness
June 1994 - Volume 4 - Issue 2 - Contributor Index : Neurosurgery QuarterlyJune 1994 - Volume 4 - Issue 2 - Contributor Index : Neurosurgery Quarterly
December 1985 - Volume 64 - Issue 12 - Contributor Index : Anesthesia & AnalgesiaDecember 1985 - Volume 64 - Issue 12 - Contributor Index : Anesthesia & Analgesia
Patent US4789732 - Bone morphogenetic protein composition - Google PatentsPatent US4789732 - Bone morphogenetic protein composition - Google Patents
PLA: Statutes & RulesPLA: Statutes & Rules
Enzyme Explorer Assay Library | Sigma-AldrichEnzyme Explorer Assay Library | Sigma-Aldrich
Chemonucleolysis - definition of chemonucleolysis by The Free DictionaryChemonucleolysis - definition of chemonucleolysis by The Free Dictionary
KEGG ENZYME: 3.4.22.6KEGG ENZYME: 3.4.22.6
Ivan Cheng, MD | Stanford Medicine ProfilesIvan Cheng, MD | Stanford Medicine Profiles
Device and method for dispensing medication to tissue lining a body cavity - KAPLOUN ILYADevice and method for dispensing medication to tissue lining a body cavity - KAPLOUN ILYA
Chiropractors are bullshit | Hacker NewsChiropractors are bullshit | Hacker News
In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode,...In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode,...
NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View
DHG Pharmaceutical productsDHG Pharmaceutical products
Intradiscal Lumbar PRP Injection - I have receivedIntradiscal Lumbar PRP Injection - I have received
Caricain - WikipediaCaricain - Wikipedia
Chemonucleolysis failures treated by PLIF.Chemonucleolysis failures treated by PLIF.
How do you treat a bulging disc? | Reference.comHow do you treat a bulging disc? | Reference.com
Protein & Peptide Letters, Volume 22 - Number 3Protein & Peptide Letters, Volume 22 - Number 3
Cimetidine Hydrochloride Monograph for Professionals - Drugs.comCimetidine Hydrochloride Monograph for Professionals - Drugs.com
Arachnoiditis - Caring MedicalArachnoiditis - Caring Medical
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth Care
ChymopapainIntervertebral Disc ChemolysisFicainBromelainsPapainCystatins2,2'-DipyridylIntervertebral Disc DisplacementDrug Information ServicesCaricaSulfhydryl CompoundsBone Morphogenetic ProteinsPatents as TopicBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone and BonesBone Morphogenetic Protein Receptors, Type IAgaveNematode InfectionsAnthelminticsPyrantelTrichurisPeptidesMyelin Basic ProteinPeptide FragmentsManuscripts as TopicAmino Acid SequenceMolecular Sequence DataHLA-DR2 Antigen
StudiesPapain and chymopapainEnzymes22.6Chemonucleolysis with chymopapainIntervertebralInjectionCaricaDoses of chymopapainInjectionsAnaphylaxisLumbarCollagenasePapaya extractsAllergicNucleus pulposusParalysis of the legsGlycoproteaseSialidaseProteasesProteinsInflammationEndopeptidasesGlycylThiolTherapeutic22.2ProteinasesDiscsSpineLatex1986NerveSevereAdultPatientsWidelyDiscMedicalTreatmentEffectsAdditionImportant
Studies1
  • Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
Papain and chymopapain15
Enzymes2
22.62
  • Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). (wikipedia.org)
  • Plant peptidases such as papain (EC 3.4.22.2), ficin (EC 3.4.22.3), chymopapain (EC 3.4.22.6), asclepain A (EC 3.4.22.7), actinidin (EC 3.4.22.14), glycyl endopeptidase (EC 3.4.22.25), caricain (EC 3.4.22.30), ananain (EC 3.4.22.31), stem bromelain (EC 3.4.22.32 and fruit bromelain (EC 3.4.22.33). (embl.de)
Chemonucleolysis with chymopapain2
Intervertebral2
Injection6
Carica2
Doses of chymopapain1
Injections3
Anaphylaxis2
Lumbar2
  • Chymopapain chemonuclolysis is the least invasive technique to treat lumbar disc herniation and relieve pain from related sciatica. (sciencephoto.com)
  • Chemonucleolysis is a treatment in which an enzyme, chymopapain, is injected directly into a herniated lumbar disc in an effort to dissolve material around the disc, thus reducing pressure and pain. (lifescript.com)
Collagenase1
  • Chymopapain and semipurified collagenase had similar morphologic and mechanical effects. (cdc.gov)
Papaya extracts1
Allergic2
Nucleus pulposus1
  • Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many practitioners learned that this was not as simple as it seemed. (burtonreport.com)
Paralysis of the legs1
Glycoprotease2
Sialidase1
  • The 561 antibody recognizes a class III group epitope, which is resistant to sialidase/glycolyprotease and chymopapain treatment. (biolegend.com)
Proteases1
  • Proteases such as chymopapain and trypsin can be used in some instances to release cells or interrupt antigen-antibody interaction. (neb.com)
Proteins1
  • Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. (orcexperts.com)
Inflammation1
Endopeptidases1
Glycyl1
Thiol2
  • The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. (biochemj.org)
  • The environment of the catalytic site of chymopapain A is markedly different from those of other cysteine proteinases studied to date, as evidenced by the pH-dependence of the second-order rate constant (k) for the reaction of the catalytic-site thiol group with 2,2′-dipyridyl disulphide. (biochemj.org)
Therapeutic1
  • A therapeutic concentration (2000 pKat/ml) of chymopapain stopped the microcirculation in the injected area immediately, with numerous microbleedings at the border zone. (lu.se)
22.21
  • The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. (biochemj.org)
Proteinases1
Discs2
  • Two spines, each of which consists of seven discs, were used for each of the following procedures: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. (biomedcentral.com)
  • The largest increase was noted in flexion in discs injected with chymopapain. (cdc.gov)
Spine2
  • Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve. (drugs.com)
  • One prominent Canadian orthopedic chymopapain advocate stated at a medical meeting that all he required was a "few cc's of chymopapain" to take care of all of his spine patients! (burtonreport.com)
Latex1
19861
Nerve1
  • The sad part of this tale is that the inadvertent deposition of chymopapain into nerve tissue as well as the sub-arachnoid space created some horrendous problems (including stroke, paraplegia, and death) for a significant number of patients. (burtonreport.com)
Severe1
Adult1
  • Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
Patients2
Widely1
  • Its fruits, stems, leaves, and roots are used in a wide range of medical applications, including the production of two important bioactive compounds (chymopapain and papain), which are widely used for digestive diseases [ 19 - 21 ]. (hindawi.com)
Disc3
  • Why, he reasoned couldn't chymopapain also dissolve the collagen in a herniated disc? (burtonreport.com)
  • From this basic observation the saga of chemonucleolysis (enzymatic dissolution of disc collagen) with chymopapain (the active ingredient in Adolf's meat tenderizer) was born. (burtonreport.com)
  • The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published but we are not aware of any previous quantitative studies on procedures for removing as much nucleus as possible from the disc. (biomedcentral.com)
Medical2
  • The presence of other medical problems may affect the use of chymopapain. (drugs.com)
  • Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of medical devices and techniques even today. (burtonreport.com)
Treatment1
  • Chymopapain is an enzyme that has been used successfully in the treatment of herniated nucleus, as alternative [ 7 - 9 ] or as an adjunct [ 10 ] to surgery. (biomedcentral.com)
Effects1
  • Microvascular effects of chondroitinase ABC and chymopapain. (lu.se)
Addition1
Important1
  • As it turned out, even when chymopapain was injected into the right location there were important associated liabilities. (burtonreport.com)
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity... (biochemj.org)
Chymopapain (Injection Route) Proper Use - Mayo Clinic
Chymopapain (Injection Route) Proper Use - Mayo Clinic (mayoclinic.org)
June 1994 - Volume 4 - Issue 2 - Contributor Index : Neurosurgery Quarterly
June 1994 - Volume 4 - Issue 2 - Contributor Index : Neurosurgery Quarterly (journals.lww.com)
Ivan Cheng, MD | Stanford Medicine Profiles
Ivan Cheng, MD | Stanford Medicine Profiles (med.stanford.edu)
Federal Register :: Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...
Federal Register :: Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for... (federalregister.gov)
Cimetidine Hydrochloride Monograph for Professionals - Drugs.com
Cimetidine Hydrochloride Monograph for Professionals - Drugs.com (drugs.com)
Arachnoiditis - Caring Medical
Arachnoiditis - Caring Medical (caringmedical.com)
The Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton Report
The Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton Report (burtonreport.com)
Red Papaya | Gardening Central
Red Papaya | Gardening Central (gardeningcentral.org)
Papaya fruit: Health benefits, uses, and risks
Papaya fruit: Health benefits, uses, and risks (medicalnewstoday.com)
NIOSHTIC-2 Publications Search - 00184892 - Chemonucleolysis in the treatment of lumbar disc disease.
NIOSHTIC-2 Publications Search - 00184892 - Chemonucleolysis in the treatment of lumbar disc disease. (cdc.gov)
Digibind (Digoxin Immune Fab): Uses, Dosage, Side Effects, Interactions, Warning
Digibind (Digoxin Immune Fab): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
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Increase or decrease in stability after nucleotomy? Conflicting in vitro and in vivo results in the sheep model | Journal of... (rsif.royalsocietypublishing.org)
Diagnosis and treatment of sciatica | The BMJ
Diagnosis and treatment of sciatica | The BMJ (bmj.com)
3 Ways to Cure a Morning Stomach Ache - wikiHow
3 Ways to Cure a Morning Stomach Ache - wikiHow (wikihow.com)
Intradiscal Platelet Rich Plasma - Full Text View - ClinicalTrials.gov
Intradiscal Platelet Rich Plasma - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Internet Scientific Publications
Internet Scientific Publications (ispub.com)
Percutaneous Coronary Intervention in Chronic Total Occlusion.
Percutaneous Coronary Intervention in Chronic Total Occlusion. (bioportfolio.com)
Microscopically Assisted Percutaneous Technique as a Minimally Invasive Approach to the Posterior Spine | SpringerLink
Microscopically Assisted Percutaneous Technique as a Minimally Invasive Approach to the Posterior Spine | SpringerLink (link.springer.com)
SMART: Pept_C1 domain annotation
SMART: Pept_C1 domain annotation (smart.embl.de)
Sunny News 16th-29th Feb,2012 by Vaibhav Narula - issuu
Sunny News 16th-29th Feb,2012 by Vaibhav Narula - issuu (issuu.com)
Fiji Island Holiday Blog | Jean-Michel Cousteau Resort Fiji
Fiji Island Holiday Blog | Jean-Michel Cousteau Resort Fiji (fijiresort.com)
Papaya Leaf Tea Shows Anticancer Abilities | EmaxHealth
Papaya Leaf Tea Shows Anticancer Abilities | EmaxHealth (emaxhealth.com)
Medical Dictionary of Health Terms: A-C - Harvard Health
Medical Dictionary of Health Terms: A-C - Harvard Health (health.harvard.edu)
Eat papaya to get rid of wrinkles & a round tummy
Eat papaya to get rid of wrinkles & a round tummy (vivawoman.net)
Pawpaw a.k.a Papaya Nectar (recipe) - TriniGourmet
Pawpaw a.k.a Papaya Nectar (recipe) - TriniGourmet (trinigourmet.com)
Benefits Of Papaya | Health And Nutrition Tips
Benefits Of Papaya | Health And Nutrition Tips (healthandnutritiontips.net)
Papaya's Health Benefits
Papaya's Health Benefits (ecochildsplay.com)
Papaya During Pregnancy: Does It Cause Miscarriage?
Papaya During Pregnancy: Does It Cause Miscarriage? (momjunction.com)
Goat Anti-Mouse IgG Magnetic Beads Protocol | NEB
Goat Anti-Mouse IgG Magnetic Beads Protocol | NEB (neb.com)
Studies on the molecular variability in Indian isolates of Papaya ringspot virus
Studies on the molecular variability in Indian isolates of Papaya ringspot virus (alliedacademies.org)
Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...
Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a... (bmcmusculoskeletdisord.biomedcentral.com)
Top Natural Anti-Inflammatory Foods To Add To Your Diet
Top Natural Anti-Inflammatory Foods To Add To Your Diet (faithful-to-nature.co.za)