Chymopapain
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Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
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A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (1/37)
Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells. (+info)Single-blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. (2/37)
This single-blind randomised clinical trial compared osteopathic manipulative treatment with chemonucleolysis (used as a control of known efficacy) for symptomatic lumbar disc herniation. Forty patients with sciatica due to this diagnosis (confirmed by imaging) were treated either by chemonucleolysis or manipulation. Outcomes (leg pain, back pain and self-reported disability) were measured at 2 weeks, 6 weeks and 12 months. The mean values for all outcomes improved in both groups. By 12 months, there was no statistically significant difference in outcome between the treatments, but manipulation produced a statistically significant greater improvement for back pain and disability in the first few weeks. A similar number from both groups required additional orthopaedic intervention; there were no serious complications. Crude cost analysis suggested an overall financial advantage from manipulation. Because osteopathic manipulation produced a 12-month outcome that was equivalent to chemonucleolysis, it can be considered as an option for the treatment of symptomatic lumbar disc herniation, at least in the absence of clear indications for surgery. Further study into the value of manipulation at a more acute stage is warranted. (+info)Intradiscal pressure after intradiscal injection of hypertonic saline: an experimental study. (3/37)
Although chemonucleolysis with chymopapain is a long-established treatment for lumbar intervertebral disc herniation, serious complications have been reported. Accordingly, alternative substances for chemonucleolysis have been sought. The main beneficial effect of chemonucleolysis derives from the decrease in intradiscal pressure. Several previous studies have investigated the relationship between physiological saline injection and disc mechanics in cadaveric specimens [2, 5, 16]. However, no previous study has assessed the intradiscal pressure after intradiscal injection of "hypertonic saline" in living animals. The present study compared the changes in intradiscal pressure after intradiscal injection of hypertonic saline with those after chymopapain injection. The lumbar intervertebral discs of 26 living rabbits were examined: 10% hypertonic saline was injected in ten rabbits, and chymopapain (10 pikokatal units) was injected intradiscally in another ten, with the remaining six being used as controls. The intradiscal pressure was measured at 1, 4, and 12 weeks after injection. The intradiscal pressure of the hypertonic saline-injected group at 4 weeks was significantly lower than that of the control group, but by 12 weeks it had recovered. On the other hand, that of the chymopapain-injected group remained significantly lower than that of the control group at 12 weeks. The results of this study found that hypertonic saline injected into the intervertebral discs temporarily decreased the intradiscal pressure. (+info)Chemonucleolysis: the state of the art. (4/37)
This review presents the history of chemonucleolysis, the techniques, indications, contraindications, and complications. Presenting an historical overview and comparison of success rates with surgical discectomy may provide a fresh understanding of the controversy surrounding chemonucleolysis and establish its efficacy in relation to more invasive treatments. A review of the literature from 1973 through 1998 for chemonucleolysis, open discectomy, and microdiscectomy provided published success rates for these procedures, and a mean rate with standard deviation was determined. In the experience and opinion of the authors, chemonucleolysis remains a viable alternative for patients who have exhausted all conservative means of treatment. Proper patient selection leads to success rates comparable to open discectomy and microdiscectomy. (+info)Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water. (5/37)
BACKGROUND: This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK) and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI) of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. RESULTS: The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. CONCLUSION: The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn.H2O.Sn) of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design. (+info)The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage. (6/37)
OBJECTIVE: The purpose of this work was to test the effect of inhibition of bone remodeling, through the use of the bisphosphonate, zoledronic acid, on cartilage matrix damage in an animal model of cartilage matrix damage. DESIGN: New Zealand white rabbits were divided into four groups for treatment purposes: (1) untreated controls; (2) injected into one knee joint with the cartilage matrix degradation enzyme, chymopapain; (3) injected into one knee joint with chymopapain and also given subcutaneous injections of the bisphosphonate, zoledronic acid, three times per week until sacrifice at either day 28 or 56 post-chymopapain-injection; (4) received only the zoledronic acid injections. At sacrifice, the knee joints were examined grossly and histologically, and biochemically for proteoglycan content. Urine samples were analysed, at intervals, for levels of collagen cross-links which are biochemical markers of cartilage and bone. RESULTS: Animals receiving both intraarticular chymopapain injections and subcutaneous zoledronic acid injections displayed a significantly lower degree of grossly and histologically detectable cartilage degeneration on the tibial articular surfaces (the articular surface displaying the greatest degree of degeneration) than did animals only receiving the chymopapain injections. In addition, urinary levels of collagen cross-links for bone and cartilage were significantly higher in those animals only receiving chymopapain injections. CONCLUSION: The bone resorption observed after chymopapain injection into the rabbit knee joint can be inhibited through the use of the bisphosphonate, zoledronic acid. Furthermore, zoledronic acid does not increase the level of cartilage degeneration and appears to provide some level of chondroprotection in this model. (+info)Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. (7/37)
OBJECTIVE: To determine if oral glucosamine (GlcN) improves joint biology after acute damage by a protease. METHODS: The effect of 8 weeks of dietary GlcN (20 or 100 mg/kg/day) on knee joint cartilage was evaluated in 2.2-kg male NZW rabbits with and without damage introduced by intraarticular injection of chymopapain (CP). Cartilage was evaluated histologically and scored according to the Mankin scale. Analyses of total hydroxyproline and glycosaminoglycan (GAG) contents and reverse transcription-polymerase chain reaction (RT-PCR) analysis of selected genes were performed. RESULTS: After 8 weeks, there was no effect of GlcN on the GAG content of normal cartilage. Both levels of GlcN treatment significantly increased the sulfated GAG content in the cartilage of the medial femoral condyle in damaged and contralateral knees, but did not change the collagen content. In CP-injected knees, there was still some loss of surface proteoglycan (PG) that was not completely corrected by dietary GlcN. Even after 8 weeks, levels of messenger RNA (mRNA) detected by RT-PCR showed changes indicative of damage and repair, such as elevated type II collagen mRNA, and these levels were not influenced by GlcN treatment. Meniscal GAG content was increased in the contralateral knee of rabbits receiving high-dose GlcN, but was decreased in those receiving no GlcN or low-dose GlcN. Neither diet nor treatment affected the meniscal collagen content. CONCLUSION: These results suggest that oral GlcN treatment might be useful in a situation where GlcN is limiting, such as where there is a rapid replacement of cartilage PG. (+info)Chemonucleolysis. (8/37)
A prospective study of 480 patients who underwent enzymatic dissolution of the nucleus pulposus with chymopapain is reported. Seventy per cent of patients with the clincial criteria for a disc herniation had a favourable response to chemonucleolysis. The commonest cause of failure was persistent back pain. In patients with sequestered discs or lateral recess stenosis surgical intervention was not made more difficult by chemonucleolysis. Those with a previous operation, spinal stenosis or psychogenic components to the disability had very poor results. Complications were few and easily managed. (+info)
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...
Chymopapain Injection Advanced Patient Information - Drugs.com
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US Patent for Method for isolating cells from tissue with a composition containing collagenase and chymopapin Patent (Patent # ...
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Caricain
Zucker S, Buttle DJ, Nicklin MJ, Barrett AJ (April 1985). "The proteolytic activities of chymopapain, papain, and papaya ... Robinson GW (August 1975). "Isolation and characterization of papaya peptidase A from commercial chymopapain". Biochemistry. 14 ... chymopapain S, Pp) is an enzyme. This enzyme catalyses the following chemical reaction Hydrolysis of proteins with broad ... multiple forms of chymopapain A and papaya proteinase omega". The Biochemical Journal. 228 (2): 525-7. doi:10.1042/bj2280525. ...
Glycyl endopeptidase
Polgár L (April 1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochimica et ... Glycyl endopeptidase (EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya ... proteinase 4, PPIV, chymopapain M) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage: ...
Discolysis
The procedure was first reported by Lyman W. Smith in 1964, and used chymopapain. Discolysis using chymopapain is no longer ...
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"Transforaminal Posterolateral Endoscopic Discectomy With or Without the Combination of a Low-Dose Chymopapain: A Prospective ...
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Patients with allergies to papain, chymopapain, other papaya extracts or the pineapple enzyme bromelain may also be at risk for ...
List of drugs: Cf-Ch
Chronovera Chronulac Chymex Chymodiactin chymopapain (INN) chymotrypsin (INN). ...
Ficain
... and chymopapain. It is one of the most commonly used for differentiating many blood group antigens: For example, it destroys M ...
List of MeSH codes (D08)
... chymopapain MeSH D08.811.277.656.300.215.350 - ficain MeSH D08.811.277.656.300.215.585 - papain MeSH D08.811.277.656.300.480 - ...
ATC code M09
M09AA01 Hydroquinine M09AA72 Quinine, combinations with psycholeptics M09AB01 Chymopapain M09AB02 Collagenase clostridium ...
List of EC numbers (EC 3)
... chymopapain, now EC 3.4.22.6 EC 3.4.4.12: ficin, now EC 3.4.22.3 EC 3.4.4.13: thrombin, now EC 3.4.21.5 EC 3.4.4.14: plasmin, ... chymopapain EC 3.4.22.7: asclepain EC 3.4.22.8: clostripain EC 3.4.22.9: yeast proteinase B. Now EC 3.4.21.48, cerevisin EC 3.4 ...
Chymopapain
... (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Studying A280 chymopapain is found in the fraction of 750-1000 ml. Once chymopapain has been isolated, it can be crystallized ... Chymopapain's structure was solved by X-ray diffraction techniques. Analysis of this structure showed chymopapain to have 7 ... Chymopapain presents a quaternary structure characterized by the formation of homo dimers, which means that two chymopapain ...
Chymopapain S
... may refer to one of two enzymes: Chymopapain Caricain This disambiguation page lists articles associated with the ... title Chymopapain S. If an internal link led you here, you may wish to change the link to point directly to the intended ...
Chymopapain - Wikipedia
Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme ... Studying A280 chymopapain is found in the fraction of 750-1000 ml. Once chymopapain has been isolated, it can be crystallized ... Chymopapains structure was solved by X-ray diffraction techniques. Analysis of this structure showed chymopapain to have 7 ... Chymopapain presents a quaternary structure characterized by the formation of homo dimers, which means that two chymopapain ...
Chymopapain S - Wikipedia
Chymopapain Injection Advanced Patient Information - Drugs.com
Detailed drug Information for chymopapain Injection. Includes common brand names, drug descriptions, warnings, side effects and ... Uses For chymopapain. Chymopapain is injected directly into a herniated ("slipped) disk in the spine to dissolve part of the ... Proper Use of chymopapain. Dosing. The dose of chymopapain will be different for different patients. Follow your doctors ... Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain ...
Chymopapain (Injection Route) Proper Use - Mayo Clinic
chymopapain from papaya latex Global Market and Forecast Research : ReportsnReports
65 Pages Report] Check for Discount on chymopapain from papaya latex Global Market and Forecast Research report by ChemReport. ... chymopapain from papaya latex Global Market and Forecast Research Table of Contents Part 1: General Information of chymopapain ... Potential users of chymopapain from papaya latex The main trading companies of chymopapain from papaya latex List of Figures ... 2.2 Construction of Industry Chain of chymopapain from papaya latex Chapter 3: End User of chymopapain from papaya latex List ...
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Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for...
... chymopapain 10,000 units/vial injection) was not withdrawn from sale for reasons of safety or effectiveness. This determination ... Determination That Chymopapain 10,000 Units/Vial Injection Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness. ... This determination will allow FDA to Start Printed Page 3887approve abbreviated new drug applications (ANDAs) for chymopapain ... CHYMODIACTIN (chymopapain 10,000 units/vial injection) is the subject of NDA 18-663. CHYMODIACTIN is indicated for the ...
Microvascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbits
... Olmarker, K ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Chymopapain induced severe effects on the cartilage and surrounding tissues. Microangiography revealed a vessel-free zone at ... Animals, Cartilage, Cheek, Chondroitin Lyases, Chondroitinases and Chondroitin Lyases, Chymopapain, Cricetinae, Mesocricetus, ...
The Tale of the Floppy Eared Bunny (The Saga of Chymopapain) - The Burton Report
Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many ... Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of ... There can be no question but that the M2H factor for chymopapain was one of highest ever recorded. Because it wasnt released ... Chemonucleolysis with chymopapain (or other enzymes such as collagenase) really werent a bad idea if qualified people were ...
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity...
Towards these substrates chymopapain A has kcat./km values similar to those of actinidin and of papaya proteinase omega and ... Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ... Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity- ...
Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a...
... unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. ... The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published ... A brush is useful in removing strands of nucleus loosened by chymopapain. ... significantly more nucleus is removed if chymopapain is used in addition to rongeurs. ...
Chymopapain Expert for Consulting, Expert Witness
Experts available for chymopapain consulting, expert witness, or analyst services for business, legal, and technical ... Chymopapain Experts. The following experts are available as chymopapain consultants and chymopapain expert witnesses. ORC ... Definition: Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. ...
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Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ... Decreased Incidence and Mortality of Anaphylaxis to Chymopapain. Moss, Jonathan; Roizen, Michael F.; Nordby, Eugene J.; More ...
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Chymopapain and semipurified collagenase had similar morphologic and mechanical effects. The temporary increases in flexibility ... The largest increase was noted in flexion in discs injected with chymopapain. By 3 months, all lateral bending flexibilities ... or chymopapain. Controls consisted of saline-injected and uninjected discs. The bending and torsional properties of each disc ...
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Chymopapain (brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a ... 1.Rarely used technique involving injection of chymopapain into the nucleus pulposus of an intervertebral disc as a therapeutic ... medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, ... http://en.wikipedia.org/wiki/Chymopapain. __________________________________________________ __________________. Optum Encoder ...
Chemonucleolysis failures treated by PLIF.
22.6Chemonucleolysis with chymopapainIntervertebralPapain and chymopapain in papayaInjectionEnzymes like papainDoses of chymopapainCaricaInjectionsProteasesCollagenasePapaya extractsCysteineDigestionNucleus pulposusAnaphylaxisProteolyticGlycoproteaseLumbarSialidaseProteinInflammationAllergicEndopeptidasesThiolDiscectomyCatalyticTherapeuticProteins22.2ProteinasesLatexDiscsNerveSevereAdultRarelyPatientsDiscTreatmentPresenceFoundMedicalEffectsAddition
22.62
- Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). (wikipedia.org)
- Plant peptidases such as papain (EC 3.4.22.2), ficin (EC 3.4.22.3), chymopapain (EC 3.4.22.6), asclepain A (EC 3.4.22.7), actinidin (EC 3.4.22.14), glycyl endopeptidase (EC 3.4.22.25), caricain (EC 3.4.22.30), ananain (EC 3.4.22.31), stem bromelain (EC 3.4.22.32 and fruit bromelain (EC 3.4.22.33). (embl.de)
Chemonucleolysis with chymopapain3
- Chemonucleolysis with chymopapain (or other enzymes such as collagenase) really weren't a bad idea if qualified people were involved in injecting them. (burtonreport.com)
- After a respectful period of time chemonucleolysis with chymopapain began to re-emerge in Europe in a lower dose application….where it remains today. (burtonreport.com)
- Five-year results from chemonucleolysis with chymopapain or collagenase: A prospective randomized study. (thefreedictionary.com)
Intervertebral2
- 1.Rarely used technique involving injection of chymopapain into the nucleus pulposus of an intervertebral disc as a therapeutic option for the treatment of a herniated nucleus pulposis (slipped disk). (aapc.com)
- Chemonucleolysis involved the injection of therapeutic doses of chymopapain into the intervertebral disc space to induce depolymerization of mucoprotein. (cdc.gov)
Papain and chymopapain in papaya2
- Presence of protein digesting enzymes like papain and chymopapain in papaya reduces inflammations and cures arthritis pain. (selfgrowth.com)
- The presence of papain and chymopapain in papaya is in part responsible for the anti-inflammatory effects of the fruit. (mercola.com)
Injection6
- Another dangerous side effect of chymopapain injection is a severe allergic reaction called anaphylaxis. (drugs.com)
- Previous chymopapain injection-Increased risk of serious allergic reactions. (drugs.com)
- As the laboratory staff watched in awe the rabbit's ears began to wilt following the intravenous injection of the enzyme chymopapain. (burtonreport.com)
- The dogs were killed 2, 4, 12, 26, and 52 weeks following injection with 0.1-0.15 ml of either crude collagenase, semipurified collagenase, or chymopapain. (cdc.gov)
- This was the result of a chymopapain injection, six months prior). (healingwell.com)
- Although ablation can be achieved with a laser, chymopapain injection and intradiskal electrotherapies also have been utilized. (aaos.org)
Enzymes like papain1
- It is rich in enzymes like papain and chymopapain, which aids digestion, prevents bloating and other digestive disorders. (themedguru.com)
Doses of chymopapain1
- The following information includes only the average doses of chymopapain. (drugs.com)
Carica4
- Chymopapain A was isolated from the dried latex of papaya (Carica papaya) by ion-exchange chromatography followed by covalent chromatography by thiol-disulphide interchange. (biochemj.org)
- Chymopapain (brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). (aapc.com)
- The chemical constituents of Carica papaya include papain and chymopapain, which are suggested to aid digestion. (ispub.com)
- Papaya (Carica papaya L.), a popular fruit tree of tropical and subtropical countries of the World, is considered as one of the rich source of vitamins A and C. In addition, it contains enzyme papain and chymopapain, both of which are widely used in the food and drug [ 1 ]. (alliedacademies.org)
Injections3
- Chymopapain injections are given only in a hospital, usually in an operating room, by your surgeon. (drugs.com)
- 1] Chymopapain injections are normally given under local, rather than general, anaesthesia. (aapc.com)
- Other surgical options include chymopapain injections and microendoscopic surgery. (reference.com)
Proteases1
- Proteases such as chymopapain and trypsin can be used in some instances to release cells or interrupt antigen-antibody interaction. (neb.com)
Collagenase1
- Chymopapain and semipurified collagenase had similar morphologic and mechanical effects. (cdc.gov)
Papaya extracts1
- Papain shares allergenic structures with (i) chymopapain and other papaya extracts. (btgplc.com)
Cysteine3
- As well as all the other enzymes in the PLCPs group, chymopapain is a cysteine protease. (wikipedia.org)
- The environment of the catalytic site of chymopapain A is markedly different from those of other cysteine proteinases studied to date, as evidenced by the pH-dependence of the second-order rate constant (k) for the reaction of the catalytic-site thiol group with 2,2′-dipyridyl disulphide. (biochemj.org)
- The striking bell-shaped component that is a characteristic feature of the reactions of S-/ImH+ (thiolate/imidazolium) ion-pair components of many cysteine-proteinase catalytic sites with the 2,2′-dipyridyl disulphide univalent cation is not present in the pH-k profile for the chymopapain A reaction. (biochemj.org)
Digestion2
- Medicinally it has been valued for its enzymes, papain and chymopapain, which help with the digestion of proteins. (emaxhealth.com)
- A great natural energy drink, containing special protein digesting enzymes papain and chymopapain that aids healthy digestion. (ecochildsplay.com)
Nucleus pulposus1
- Even though injecting chymopapain simply required placing the tip of a needle in the nucleus pulposus of a disc many practitioners learned that this was not as simple as it seemed. (burtonreport.com)
Anaphylaxis1
- Before receiving chymopapain, you should discuss its use, and the possibility of anaphylaxis or other serious side effects, with your doctor. (drugs.com)
Proteolytic2
- The latex contains the protein-degrading (proteolytic) and mucolytic enzymes papain and chymopapain. (fijiresort.com)
- Researchers believe the proteolytic enzymes chymopapain and papain in papaya are responsible for these beneficial effects. (ecobeautyeditor.com)
Glycoprotease2
- Epitope Class III: Clone 581 recognizes a sialidase / glycoprotease / chymopapain insensitive class III epitope. (beckman.com)
- It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. (novusbio.com)
Lumbar2
- Chymopapain chemonuclolysis is the least invasive technique to treat lumbar disc herniation and relieve pain from related sciatica. (sciencephoto.com)
- Chemonucleolysis is a treatment in which an enzyme, chymopapain, is injected directly into a herniated lumbar disc in an effort to dissolve material around the disc, thus reducing pressure and pain. (lifescript.com)
Sialidase1
- The 561 antibody recognizes a class III group epitope, which is resistant to sialidase/glycolyprotease and chymopapain treatment. (biolegend.com)
Protein4
- The latter procedure was used to produce fully active enzyme containing one essential thiol group per molecule of protein, to establish that the chymopapain A molecule contains, in addition, one non-essential thiol group per molecule and to recalculate the literature value of epsilon 280 for the enzyme as 36 000 M−1 × cm −1. (biochemj.org)
- Papaya contains several unique protein-digesting enzymes including papain and chymopapain. (vivawoman.net)
- It's also a source of papain and chymopapain, protein-digesting enzymes which help reduce inflammation. (faithful-to-nature.co.za)
- [ 2 ] Papaya contains papain , chymopapain, glycyl endopeptidase, and glutamine cyclotransferase - all of which help digest protein. (globalhealingcenter.com)
Inflammation2
- Papain and another enzyme, chymopapain also reduces inflammation, especially in the area of joints. (healthandnutritiontips.net)
- Two enzymes in papaya - papain and chymopapain - have been found to help relieve inflammation, a major problem for people suffering from diseases like osteoarthritis and rheumatoid arthritis. (hubpages.com)
Allergic2
- Tell your doctor if you have ever had any unusual or allergic reaction to chymopapain or any other medicines. (drugs.com)
- The procedure's use is extremely limited, in part because some patients may have a life-threatening allergic reaction to chymopapain. (lifescript.com)
Endopeptidases1
- Latex (the milky liquid) is a mixture of papain, endopeptidases, and chymopapain (3) . (momjunction.com)
Thiol1
- Chymopapain - A thiol protease that catalyzes the hydrolysis of proteins and polypeptides to smaller polypeptides. (orcexperts.com)
Discectomy1
- Day A, Savage D, Friedman W (1986) Chemonucleolysis versus open discectomy: the case against chymopapain. (springer.com)
Catalytic2
- When this two bonds are broken, the catalytic triad from the chymopapain is available to be used again. (wikipedia.org)
- Thus the abnormal catalytic-site environment of chymopapain A detected by the reactivity-probe studies, which may have consequences for the acylation step of the catalytic act, does not perturb the conformation of the bound acyl group at the acyl-enzyme-intermediate stage of catalysis. (biochemj.org)
Therapeutic1
- A therapeutic concentration (2000 pKat/ml) of chymopapain stopped the microcirculation in the injected area immediately, with numerous microbleedings at the border zone. (lu.se)
Proteins1
- It is rich in the enzymes papain and chymopapain, which help lower acidity and break down proteins in your stomach. (wikihow.com)
22.21
- The Michaelis parameters for the hydrolysis of L-benzoylarginine p-nitroanilide and of benzyloxy-carbonyl-lysine nitrophenyl ester at 25 degrees C, and I 0.1 at several pH values catalysed by chymopapain A, papaya proteinase omega, papain (EC 3.4.22.2) and actinidin (EC 3.4.22.14) were determined. (biochemj.org)
Proteinases1
- The preparation of fully active chymopapain free of contaminating proteinases. (genome.jp)
Latex1
- We provide independent and unbiased information on manufacturers, prices, production news and consumers for the global and regional (North America, Asia and Europe) market of chymopapain from papaya latex. (reportsnreports.com)
Discs2
- Two spines, each of which consists of seven discs, were used for each of the following procedures: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. (biomedcentral.com)
- The largest increase was noted in flexion in discs injected with chymopapain. (cdc.gov)
Nerve2
- Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve. (drugs.com)
- The sad part of this tale is that the inadvertent deposition of chymopapain into nerve tissue as well as the sub-arachnoid space created some horrendous problems (including stroke, paraplegia, and death) for a significant number of patients. (burtonreport.com)
Severe1
- Chymopapain induced severe effects on the cartilage and surrounding tissues. (lu.se)
Adult1
- Studies on chymopapain have been done only in adult patients, and there is no specific information comparing use of chymopapain in children with use in other age groups. (drugs.com)
Rarely1
- Very rarely, use of chymopapain may cause serious side effects, including paralysis of the legs or death. (drugs.com)
Patients3
- The dose of chymopapain will be different for different patients. (drugs.com)
- One prominent Canadian orthopedic chymopapain advocate stated at a medical meeting that all he required was a "few cc's of chymopapain" to take care of all of his spine patients! (burtonreport.com)
- Unfortunately the use of chymopapain created new problems for patients. (burtonreport.com)
Disc3
- Why, he reasoned couldn't chymopapain also dissolve the collagen in a herniated disc? (burtonreport.com)
- From this basic observation the saga of chemonucleolysis (enzymatic dissolution of disc collagen) with chymopapain (the active ingredient in Adolf's meat tenderizer) was born. (burtonreport.com)
- The results of many studies involving removal of nucleus, including chemonucleolysis, using chymopapain, have been published but we are not aware of any previous quantitative studies on procedures for removing as much nucleus as possible from the disc. (biomedcentral.com)
Treatment1
- Chymopapain is an enzyme that has been used successfully in the treatment of herniated nucleus, as alternative [ 7 - 9 ] or as an adjunct [ 10 ] to surgery. (biomedcentral.com)
Presence1
- The presence of other medical problems may affect the use of chymopapain. (drugs.com)
Found1
- Therefore, the ability to work in low pH conditions supports the idea that chymopapain can be found in lysosomes. (wikipedia.org)
Medical1
- Despite the tale of chymopapain and its unfortunate demise the M2H phenomenon is still alive and well in the over-promoting of medical devices and techniques even today. (burtonreport.com)
Effects2
- Chymopapain is no longer used as a standard method to treat chronic low back pain because of its potential side effects. (wikipedia.org)
- Microvascular effects of chondroitinase ABC and chymopapain. (lu.se)
Addition1
- significantly more nucleus is removed if chymopapain is used in addition to rongeurs. (biomedcentral.com)