1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Agencies of the FEDERAL GOVERNMENT of the United States.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Compounds consisting of two or more fused ring structures.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Volative flammable fuel (liquid hydrocarbons) derived from crude petroleum by processes such as distillation reforming, polymerization, etc.
A group of condensed ring hydrocarbons.
Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Painful URINATION. It is often associated with infections of the lower URINARY TRACT.
Means or process of supplying water (as for a community) usually including reservoirs, tunnels, and pipelines and often the watershed from which the water is ultimately drawn. (Webster, 3d ed)
The level of governmental organization and function at the national or country-wide level.
Any of several processes in which undesirable impurities in water are removed or neutralized; for example, chlorination, filtration, primary treatment, ion exchange, and distillation. It includes treatment of WASTE WATER to provide potable and hygienic water in a controlled or closed environment as well as provision of public drinking water supplies.
The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.
A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.

Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002. (1/90)

Human NAT1 and NAT2 genes were subcloned into pACYC184 vector and the plasmids thus obtained were introduced into Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1, 8-DNP/pSK1002), establishing new strains NM6001 and NM6002, respectively. We compared the sensitivities of these two strains with those of NM6000 towards carcinogenic nitroarenes and aromatic amines in the SOS/umu response. The induction of umuC gene expression by these chemicals in the presence and absence of the S9 fraction was assayed by measuring the cellular beta-galactosidase activity expressed by the umuC"lacZ fusion gene in the tester strains. 2-Nitrofluorene and 2-aminofluorene induced umuC gene expression more strongly in the NM6001 strain than in the NM6002 strain. In contrast, induction of umuC gene expression by 1, 8-dinitropyrene, 6-aminochrysene and 2-amino-3,5-dimethylimidazo[4, 5-f]quinoline was weaker in the NM6001 strain than in the NM6002 strain. 1-Nitropyrene, 2-amino-6-methyl-dipyrido[1,2-a:3', 2'-d]imidazole, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, 3-amino-1-methyl-5H-pyrido[4,3-b]indole, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3-methyl-9H-pyrido[2,3-b]indole were found to induce umuC gene expression at similar extents in both strains. These results suggest that the newly developed strains can be employed for the studies on mechanisms of genotoxicity of a variety of nitroarenes and aromatic amines, along with the assessment of cancer risk to humans.  (+info)

Three-dimensional structure of anti-5,6-dimethylchrysene-1, 2-dihydrodiol-3,4-epoxide: a diol epoxide with a bay region methyl group. (2/90)

The three-dimensional structure of a dihydrodiol epoxide of 5, 6-dimethylchrysene was elucidated by X-ray diffraction techniques. The effects of the steric overcrowding by the 5-methyl group in the bay region of this compound are described. The carbon atom of the 5-methyl group is found to lie out of the plane of the aromatic system, thereby avoiding the nearer C-H group of the epoxide ring; this C-H hydrogen atom is pushed in the opposite direction. As a result, the molecule is distorted so that the relative orientations of the epoxide group and the aromatic ring systems are very different for the diol epoxides of (nearly planar) benzo[a]pyrene (studied by Neidle and co-workers) and (distorted) 5, 6-dimethylchrysene (described here). The main effect of the 5-methyl group is to change the relative angle between the epoxide-bearing ring (the site of attack when the diol epoxide acts as an alkylating agent) and the aromatic ring system (which is presumed to lie partially between the DNA bases in the DNA adduct that is about to be formed). This may favor some specific alkylation geometry.  (+info)

Specificity of murine glutathione S-transferase isozymes in the glutathione conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11,12-diol 13,14-epoxide. (3/90)

Specificities of murine glutathione (GSH) S-transferase (GST) isozymes mGSTA1-1, mGSTA2-2, mGSTA3-3 and mGSTA4-4 (alpha class), mGSTP1-1 (pi class) and mGSTM1-1 (mu class) for GSH conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11, 12-diol 13,14-epoxide (B[g]CDE), the activated metabolites of the environmental pollutant benzo[g]chrysene (B[g]C), have been determined. When GST activity was determined as a function of varying (-)-anti- or (+)-syn-B[g]CDE concentration (10-320 microM) at a fixed saturating concentration of GSH (2 mM), each isozyme obeyed Michaelis-Menten kinetics. mGSTA1-1 was significantly more efficient than other murine GSTs in the GSH conjugation of not only (-)-anti-stereoisomer but also (+)-syn-B[g]CDE. For example, the catalytic efficiency (k(cat)/K(m)) of mGSTA1-1 towards (-)-anti-B[g]CDE was approximately 2.3- to 16.6-fold higher compared with other murine GSTs. Likewise, mGSTA1-1 was approximately 2.7-, 6.7-, 4.4- and 12.4-fold more efficient than mGSTA2-2, mGSTA3-3, mGSTP1-1 and mGSTM1-1, respectively, in catalyzing the GSH conjugation of (+)-syn-B[g]CDE. Interestingly, mGSTA4-4, which also belongs to class alpha, was virtually inactive towards both stereoisomers of B[g]CDE. The results of the present study indicate that murine GSTs, especially alpha class isozymes, significantly differ in their ability to detoxify B[g]CDE stereoisomers and that mGSTA1-1 plays a major role in the detoxification of both (-)-anti- and (+)-syn-B[g]CDE, which among four B[g]CDE stereoisomers are formed from the carcinogen B[g]C as major DNA binding metabolites.  (+info)

A phase I and pharmacological study of protracted infusions of crisnatol mesylate in patients with solid malignancies. (4/90)

This Phase I and pharmacological study was performed to assess the feasibility of administering the polycyclic aromatic hydrocarbon crisnatol in increasingly prolonged continuous i.v. infusions to patients with advanced solid malignancies. The study also sought to characterize the-principal toxicities of crisnatol on this schedule, to recommend doses for subsequent disease-directed studies, and to characterize possible associations between pharmacological parameters and toxicity. Sixteen patients were treated with 40 courses of crisnatol administered as a continuous i.v. infusion. The initial dose-schedule was 750 mg/m2/day for 6 days, and the duration of the infusion was to be progressively increased by 3-day increments to 9, 12, 15, 18, and 21. Courses were to be repeated every 4 weeks. Moderate to severe central nervous system (CNS) toxicity precluded the administration of crisnatol 750 mg/m2/day for longer than 6 days, and, therefore, the dose of crisnatol was reduced to 600 mg/m2/day. At this dose, three of five patients receiving a 12-day infusion experienced dose-limiting toxicity, which consisted of pulmonary thromboembolism (two patients) and grade 4 thrombocytopenia (one patient). None of the six patients completing a 9-day infusion at 600 mg/m2/day developed dose-limiting toxicity during the first or second course of crisnatol. At this dose level, the plasma concentrations at steady state (Css) averaged 1607.8+/-261.1 ng/ml, which exceeds minimal inhibitory concentrations for most tumors in vitro (1000 ng/ml). In fact, the administration of crisnatol at a dose of 600 mg/m2/day for 9 days resulted in the longest duration that biologically relevant plasma crisnatol concentrations have been sustained. Plasma Css values were significantly higher in patients who experienced severe CNS toxicity compared with those who did not (2465.3+/-1213.5 versus 1342+/-447.3 ng/ml; P = 0.04). There were no relationships evident between the clearance of crisnatol and indices reflecting renal and hepatic functions. One patient with a glioblastoma multiforme experienced a partial response lasting 14 months. The relative lack of intolerable CNS toxicity at the recommended dose for Phase II studies of crisnatol, 600 mg/m2/day for 9 days, as well as the magnitude of the Css values achieved and the antitumor activity observed at this dose, are encouraging. However, the mechanisms for the apparently increased thrombogenicity observed in this trial are unclear and require further elucidation.  (+info)

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. (5/90)

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in combustion products of organic matter, including cigarette smoke. Metabolically activated diol epoxides of these compounds, including benzo[a]pyrene diol epoxide (B[a]PDE), have been suggested as causative agents in the development of lung cancer. We previously mapped the distribution of B[a]PDE adducts within the p53 tumor suppressor gene (also known as TP53), which is mutated in 60% of human lung cancers, and found that B[a]PDE adducts preferentially form at lung cancer mutational hotspots (codons 154, 157, 158, 245, 248, and 273). Other PAHs may be important in lung cancer as well. METHODS: Here we have mapped the distribution of adducts induced by diol epoxides of additional PAHs: chrysene (CDE), 5-methylchrysene (5-MCDE), 6-methylchrysene (6-MCDE), benzo[c]phenanthrene (B[c]PDE), and benzo[g]chrysene (B[g]CDE) within exons 5, 7, and 8 of the p53 gene in human bronchial epithelial cells. RESULTS: CDE exposure produced only low levels of adducts. Exposure of cells to the other activated PAHs resulted in DNA damage patterns similar to those previously observed with B[a]PDE but with some distinct differences. 5-MCDE, 6-MCDE, B[g]CDE, and B[c]PDE efficiently induced adducts at guanines within codons 154, 156, 157, 158, and 159 of exon 5, codons 237, 245 and 248 of exon 7, and codon 273 of exon 8, but the relative levels of adducts at each site varied for each compound. B[g]CDE, B[c]PDE, and 5-MCDE induced damage at codon 158 more selectively than 6-MCDE or B[a]PDE. The sites most strongly involved in PAH adduct formation were also the sites of highest mutation frequency (codons 157, 158, 245, 248, and 273). CONCLUSION: The data suggest that PAHs contribute to the mutational spectrum in human lung cancer.  (+info)

Time- and dose-dependent DNA binding of PAHs derived from diesel particle extracts, benzo[a]pyrene and 5-methychrysene in a human mammary carcinoma cell line (MCF-7). (6/90)

Cultures of a human mammary carcinoma cell line (MCF-7) were exposed to the soluble organic fraction of diesel particle emissions, benzo[a]pyrene (B[a]P) and 5-methylchrysene (5-MeCHR) to study time- and dose-related PAH-DNA binding. The concentrations of 14 PAHs in three extracts were analyzed by HPLC and PAH-DNA adducts were measured by (32)P post-labeling assay. Time-dependent DNA adducts formation of 2.5 microM B[a]P was lower than that of 2.5 microM 5-MeCHR. In comparison with B[a]P, 2-fold higher adduct formation by 5-MeCHR was observed at 12 h exposure, after which BPDE adducts decreased and 5-MeCHR continued to form adducts linearly during 48 h exposure. The data for these two PAH compounds demonstrate a large variation in adduct-forming potency, which should be taken into account when estimating DNA adducts formed by mixtures of unknown PAHs. A clear dose-response effect on formation of DNA adducts was obtained for B[a]P and a Standard Reference Material (SRM) of diesel particulate matter. The amount of B[a]P contributed more to total DNA adduct formation by SRM than by three diesel extracts. Thus, no conclusions can be drawn from diesel particle-derived B[a]P as to the adduct-forming potency of other carcinogenic PAHs. There was little change in adduct levels formed by three diesel extracts from 0 to 12 h exposure. Thereafter, the number of adducts formed by RD2 increased more rapidly than those formed by RD1 and EN97. The concentrations of 14 PAHs and adduct levels analyzed at 24 and 48 h did not change in the same proportion between the extracts. Neither could PAH-DNA adduct levels be explained by the sum of strong and weak adduct-forming PAHs analyzed in the extracts. This indicates that other PAHs in the extracts RD1, RD2 and EN97 contributed to adduct formation more than the carcinogenic adduct-forming PAHs analyzed in this study.  (+info)

Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes. (7/90)

Physiological effects of estrogen on myocardium are mediated by two intracellular estrogen receptors, ERalpha and ERbeta, that regulate transcription of target genes through binding to specific DNA target sequences. To define the role of ERbeta in the transcriptional activation of both endothelial (eNOS) and inducible nitric oxide synthase (iNOS) in cardiac myocytes, we used the complete ER-specific antagonist R,R-tetrahydrochrysene (R,R-THC). R,R-THC inhibited activation of iNOS/eNOS promoter-luciferase reporter constructs (iNOS/eNOS-Luc) in a dose-dependent fashion in COS7 cells selectively transfected with ERbeta, but failed to influence ERalpha-mediated increase of iNOS/ eNOS-Luc. In neonatal rat cardiomyocytes transfected with eNOS-Luc or iNOS-Luc, incubation with 17betaestradiol (E2, 10(-8) M) for 24 h stimulated expression of eNOS and iNOS. R,R-THC (10(-5) M) completely inhibited this effect. Furthermore, eNOS and iNOS protein expression in cardiac myocytes induced by E2 was completely blocked by R,R-THC as shown by immunoblot analysis. Taken together, these results show that ERbeta mediates transcriptional activation of eNOS and iNOS by E2.  (+info)

The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice. (8/90)

Benz(a)anthracene injected subcutaneously during the first 3 days of life caused a dose related increase in the incidence of liver and lung tumours in Swiss mice but over a similar dose range, the K region epoxide of benz(a)anthracene was less effective. Neonatally injected 7-methylbenz(a) was considerably more active than its K region epoxide in increasing the incidence of liver tumours in males. Both the parent compound and the epoxide slightly raised the incidence of lung tumours. Both chrysene and its K region epoxide increased liver tumour incidence but not lung tumour incidence. The K region epoxides of dibenz(a,h)-anthracene and 3-methylcholanthrene were without apparent effect on the incidence of liver, lung or other tumours despite indications from previously reported studies that the parent hydrocarbons are active at the same dose levels. The K region epoxide of phenanthrene had no effect on the incidence of any kind of neoplasm.  (+info)

TY - JOUR. T1 - Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a lacI mammary epithelial cell line. AU - Sun, Yuan Wan. AU - Guttenplan, Joseph B.. AU - Khmelnitsky, Michael. AU - Krzeminski, Jacek. AU - Boyiri, Telih. AU - Amin, Shantu. AU - El-Bayoumy, Karam. PY - 2009/12/21. Y1 - 2009/12/21. N2 - The environmental pollutant 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. Our previous studies have shown that 6-NC is metabolized to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene (1,2-DHD-6-NC) in rats and in several in vitro systems, including human breast tissue, and the latter is the proximate carcinogenic form in the rat mammary gland. Because optically active enantiomers of numerous polynuclear aromatic hydrocarbon (PAH) metabolites including chrysene have different biological activities, ...
TY - JOUR. T1 - Tumorigenicity of 5-Methylchrysene Dihydrodiols and Dihydrodiol Epoxides in Newborn Mice and on Mouse Skin. AU - Hecht, Stephen S.. AU - Radok, Lynn. AU - Amin, Shantu. AU - Huie, Keith. AU - Melikian, Assieh A.. AU - Hoffmann, Dietrich. AU - Pataki, John. AU - Harvey, Ronald G.. PY - 1985/4/1. Y1 - 1985/4/1. N2 - 5-Methylchrysene, (±-trans-1,2-dihydro-1,2-dihydroxy-5-methylchrysene, (±-trans-7,8-dihydro-7,8-dihydroxy-5-methyl-chrysene, (±)-trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetra-hydro-5-methylchrysene (anti-DE-l), (±trans-1,2-dihydroxy-«yr?-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (syn-DE-l), and (±trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (anti-DE-ll) were tested for tumorigenicity in newborn mice and for tumor-initiating activity on mouse skin. In newborn mice, a total dose of 56 nmol of anti-DE-l induced 4.6 lung tumors/mouse and 1.2 liver tumors/mouse. These incidences were significantly higher than observed for any of the ...
TY - JOUR. T1 - Synthesis and aggregate formation of triphenylene core-centered porphyrin hexamers. AU - Hasobe, Taku. AU - Rabbani, Mohammad Gulam. AU - Sandanayaka, Atula S.D.. AU - Sakai, Hayato. AU - Murakami, Tatsuya. PY - 2010. Y1 - 2010. N2 - We demonstrate the synthesis, aggregate formation and spectroscopic property of new triphenylene core-centered porphyrin hexamers with different alkyl chain lengths.. AB - We demonstrate the synthesis, aggregate formation and spectroscopic property of new triphenylene core-centered porphyrin hexamers with different alkyl chain lengths.. UR - http://www.scopus.com/inward/record.url?scp=75649142119&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=75649142119&partnerID=8YFLogxK. U2 - 10.1039/b915983e. DO - 10.1039/b915983e. M3 - Article. C2 - 20107640. AN - SCOPUS:75649142119. VL - 46. SP - 889. EP - 891. JO - Chemical Communications. JF - Chemical Communications. SN - 1359-7345. IS - 6. ER - ...
Herein, four new H-shaped triphenylene discotic liquid crystal tetramers have been designed and synthesized using a copper-free [3+2] cycloaddition reaction between the triphenylene dimer and diazide compounds. To probe the molecular self-assembly and mesophase properties, the length and rigid spacers in diazide have been tailored.
Environmental chemicals may play a role in the etiology of human breast cancer. Aromatic amines, industrial chemicals found as environmental pollutants, have been identified as rat mammary carcinogens. We have detected the monocyclic aromatic amines, aniline, o-toluidine, and N-methylaniline at part …
MCDE is focusing on the problem of antibiotic-resistant bacteria. The lack of new antibiotic drug classes in the past two decades has lead to widespread bacterial resistance. MCDE has targeted 4 types of bacteria which account for 44% of all hospital-acquired infections. They have several promis...
We next sought to develop an assay that would examine the downstream effects of PARP inhibition, DNA damage. Although the PAR immunoassay measures the product of the enzyme targeted by PARP inhibitors and is therefore a direct reporter of target engagement, the pharmacologic objective of PARP inhibition is to impede or prevent DNA repair. Assays to evaluate this are also needed to evaluate the efficacy combining PARP inhibitors in the clinic with drugs that cause DNA damage. Such an assay would also support the PD evaluation of other types of DNA-damaging agents. The Division of Cancer Treatment and Diagnosis initiated a program to develop the indenoisoquinoline class of Top1 inhibitors (NSC 724998, 725776, and 706744; ref. 10) resulting in accumulation of double-strand DNA (dsDNA) breaks. The assay implemented for this drug effect was measurement of pS139 H2Ax (called γ-H2AX in the literature) in formalin-fixed, paraffin-embedded biopsy tissues via immunofluorescence assay (IFA) using ...
PRIMARY OBJECTIVES:. I. Determine the maximum tolerated dose of gemcitabine and flavopiridol in patients with solid tumors.. SECONDARY OBJECTIVES:. I. Determine the safety profile and toxic effects of this regimen in these patients.. II. Determine the pharmacokinetics of flavopiridol with and without gemcitabine in these patients.. III. Determine, using pharmacodynamic assays, the activity of flavopiridol as a cdk inhibitor in these patients.. IV. Determine, using pharmacodynamic assays, the markers of this regimen in these patients.. OUTLINE: This is a dose-escalation, multicenter study.. Some patients receive an initial dose of alvocidib IV over 1-7 hours on day 1 (course 0). Beginning 1 week later and for all subsequent courses, all patients receive gemcitabine hydrochloride IV over 60-150 minutes on days 1 and 15 and alvocidib IV over 1-7 hours on days 2 and 16. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.. Cohorts of 3-6 patients receive ...
65059-24-7 Synthesising 5-Methyl Chrysene | 3697-24-3 Synthesis Route, Search 5-Methyl Chrysene Synthesis route and MSDS, CAS 3697-24-3 Synthesis Route and NMR Spectrum, 3697-24-3 Precursor and Downstream Products
McLaren Bay Region in Bay City, MI - Get directions, phone number, research physicians, and compare hospital ratings for McLaren Bay Region on Healthgrades.
PURPOSE: Metarrestin is a first-in-class small molecule clinical candidate capable of disrupting the perinucleolar compartment, a subnuclear structure unique to metastatic cancer cells. This study aims to define the pharmacokinetic (PK) profile of metarrestin and the pharmacokinetic/pharmacodynamic relationship of metarrestin-regulated markers. METHODS: PK studies included the administration of single or multiple dose of metarrestin at 3, 10, or 25 mg/kg via intravenous (IV) injection, gavage (PO) or with chow to wild-type C57BL/6 mice and KPC mice bearing autochthonous pancreatic tumors. Metarrestin concentrations were analyzed by UPLC-MS/MS. Pharmacodynamic assays included mRNA expression profiling by RNA-seq and qRT-PCR for KPC mice. RESULTS: Metarrestin had a moderate plasma clearance of 48 mL/min/kg and a large volume of distribution of 17 L/kg at 3 mg/kg IV in C57BL/6 mice. The oral bioavailability after single-dose (SD) treatment was , 80%. In KPC mice treated with SD 25 mg/kg PO, plasma ...
With an adequately credentialed molecular target-scientific validation, a critically unmet medical need, and a feasible strategy for drug design-the Agents Development Pathway next proceeds along parallel tracks aimed to produce the key components for an initial clinical trial: an agent, a pharmacodynamic assay for target inhibition, and a stratification test for identifying which patients are most likely to benefit from treatment (Fig. 1). Some of the supporting tools for drug discovery and development, including cell culture or animal models, reagents for target detection, and target function assessment, etc., are the legacy of target validation experiments; other such tools need to be established. As such, some of the limitations of current approaches to target validation define a compelling agenda for the development of additional research tools and resources. Closer interaction among discovery researchers is needed to move beyond the simple model of, first, identifying a target, and then, ...
However, no protein accumulation occurred in the PMS controls.. After 10 days of incubation the VE-822 culture entered the stationary phase. During this period the concentration of chrysene in the medium decreased from 400 to 140 mg L−1, i.e. 60% of the chrysene was degraded during the 12 days of incubation. TLC of the ethyl acetate extract of the supernatants from the washed-cell incubations with chrysene showed the presence of polar metabolites. Metabolic intermediates were tentatively identified by comparing their Rf values with those of the respective standard reference compounds. Chrysene moved along with the solvent front. 1-Hydrox-2-naphthoic acid (Rf 0.43) and salicylic acid (Rf 0.15) were identified as the probable intermediates. A spot with Rf value of 0.86 did not match with any standards tested. The extracts were then analysed by HPLC and the individual spots on TLC were further characterized by LC-ESI-MS. Retention times from HPLC analysis (Fig. 2) and LC-ESI-MS. characteristics ...
405140-36-5 is the CAS No of Benzo[g]quinoline-5,10-dione,1-(2,2-dimethoxyethyl)-1,2-dihydro-2,2-dimethyl- ; physical and chemical property of 405140-36-5, Benzo[g]quinoline-5,10-dione,1-(2,2-dimethoxyethyl)-1,2-dihydro-2,2-dimethyl- is provided by ChemIndex
As one of the Big Three automobile manufacturers in the U.S., Ford could make a big difference. Instead, Ford plans to focus on sales of higher-emission SUVs and trucks in the U.S. Theyre even introducing a new diesel F-150 truck, which means now Americas best-selling vehicle, is offered with an engine that emits even more potent mammary carcinogens ...
These properties are changing weekly, this is how fast the housing sales are moving. Please contact us if you would like to be sent the latest properties available this week.. These properties are changing weekly, this is how fast the housing sales are moving. Please contact us if you would like to be sent the latest properties available this week.. Situated in the fast-growing Moreton Bay region, also known as the economic heart of the northern growth corridor of south east Queensland, Caboolture is set for massive population and employment growth.. Forecasts suggest an additional 232,000 will be living in the region by 2036, bringing the total population to a massive 622,000 people. Approximately 41,000 new residential dwellings will be provided to residents of the Moreton Bay region from 2009 to 2031.. 30,000 new jobs will also be available as a result of the projected 120 per cent employment growth. The majority of this job growth will be triggered by the $20 billion of proposed, approved, ...
Jill shares her emotional story of what happened when she went into labor and the all-hands-on-deck efforts of McLaren Bay Region medical staff when things didnt go as planned.
Browse local and regional news from the Hawkes Bay region, including Napier, Hastings, Dannevirke and Havelock North - hawkesbaytoday.co.nz
Structure, properties, spectra, suppliers and links for: (3R)-5,7-Dihydroxy-4H,6H-spiro[chromene-3,5-cyclobuta[f][1,3]benzodioxol]-4-one.
Structure, properties, spectra, suppliers and links for: 2-[4-(4-Chlorophenyl)cyclohexylidene]-3,4-dihydroxy-1(2H)-naphthalenone.
알페카 항성계의 구성원 중 밝은 쪽인 알페카 A는 분광형 A0V의 주계열성이며 태양 질량의 2.6배이다. 반지름은 태양의 2.89배에서 3.04배이다.[4][6] IRAS는 알페카 A를 관측하여 24 μm와 70 μm에서 초과 적외선 복사를 감지했다.[8] 이로 보아 A 주위에 먼지로 이루어진 거대한 원반이 있어 베가에서 관측되는 것과 유사한 원시행성계가 생성 중일 가능성이 있다. 먼지 원반은 항성으로부터 약 60 천문단위 거리까지 확장되어 있다.[9] 짝별 알페카 B는 분광형 G5의 주계열성으로 질량은 태양의 92%, 반지름은 태양의 90%이다. 알페카 B의 엑스선 광도는 6 × 1028 erg s−1로 태양의 최고 광도보다 30배 강한 값이다. 이처럼 강력한 엑스선 발산으로부터 B가 젊은 별임을 추정할 수 있다. 코로나 온도는 약 500만 켈빈으로 태양 코로나보다 훨씬 더 뜨겁다. 항성 적도에서의 자전 속도 ...
D・m・纽恩斯, L・克鲁辛艾尔鲍姆, 金德起, 陈冠能, 朴炳柱, B・g・埃尔米格林, 林仲汉, C・科桑达拉曼, S・波卢索萨 ...
EWGs Tap Water Database Benzo[g,h,i]perylene results for Washington Aqueduct Division | Benzo[g,h,i]perylene. Find out what is in your tap water
The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in multiple myeloma (MM), a blood cancer associated with uncontrolled proliferation of bone marrow plasma cells. This study aimed to develop a robust clinical pharmacodynamic (PD) assay to measure the on-target PD effects of the selective PI3K inhibitor GDC-0941 in MM patients. We conducted an in vitro drug wash-out study to evaluate the feasibility of biochemical approaches in measuring the phosphorylation of S6 ribosomal protein (S6), one of the commonly used PD markers for PI3K pathway inhibition. We then developed a 7-color phospho-specific flow cytometry assay, or phospho flow assay, to measure the phosphorylation state of intracellular S6 in bone marrow aspirate (BMA) and peripheral blood (PB). Integrated mean fluorescence intensity (iMFI) was used to calculate fold changes of phosphorylation. Assay sensitivity was evaluated by comparing phospho flow with Meso Scale Discovery (MSD) and immunohistochemistry (IHC) assays.
Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 µmol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The ...
Clean Seas Environment Monitoring Programme (CSEMP) accessment of benzo[g,h,i]perylene in biota (blue mussel soft body) at station WestChan_Dart_sh01, Sandridge (Dart Dart) from the Marine Environment Monitoring and Assessment National database (MERMAN).
Dr Philip Scarlett at Strathpine Surgical in Strathpine, Caboolture, and Moreton Bay Region, Queensland offers breast surgery such as lumpectomy, mastectomy and breast biopsy to treat breast cancer and breast problems
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The efficacy of a newly developed gas chromatography-negative ion chemical ionization-mass spectrometry-selected ion monitoring (GC-NICI-MS-SIM) assay for measuring globin adducts of benzo[a]pyrene (B[a]P) and chrysene diol epoxides in human was evaluated. In this pilot study, smokers and nonsmokers were selected as exposed and nonexposed groups. Using [2H12]r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyren e ([2H12]trans,anti-B[a]P-tetraol) as an internal standard, B[a]P-tetraols released from globin after hydrolysis and derivatization were quantified by GC-NICI-MS-SIM. Levels of trans-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (chrysene-DE)-globin adducts were estimated by assuming that the recovery and the MS response of the perdeuterated B[a]P-tetraol internal standard reflected the recovery and MS response of chrysene tetraols. The assay was found to be reproducible and sensitive enough to detect both analytes in all samples. The mean levels of B[a]P-tetraols released ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
TRACTION first recognised the need to have a presence in the Moreton Bay region when it secured funding to deliver 1-day workshops for students from Caboolture State High School in 2018. In 2021, TRACTION expects to formalise an exciting partnership which will see it establish a workshop in Morayfield from which it reach young people across the Moreton Bay region ...
From Te Mata Peak, on a clear day, you can see the whole of Hawkes Bay laid out before you - up to Māhia Peninsula in the north and the rugged hills behind the coast to the south. Read the story . . . ...
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5,20-dihydroxy-6,7-epoxy-1-oxo-5-witha-2,24-dienolide: has immunomodulating properties; RN given refers to (5alpha,6alpha,7alpha,22R)-isomer
TY - JOUR. T1 - Novel aromatic N-oxyl radical based on the benzo[g]quinoline skeleton. T2 - Synthesis and intermolecular ferromagnetic interaction. AU - Yao, Masaru. AU - Inoue, Hidenari. AU - Yoshioka, Naoki. PY - 2005/1/24. Y1 - 2005/1/24. N2 - A novel stable organic radical, 2,2-diphenyl-1,2-dihydrobenzo[g]quinoline- N-oxyl (2), has been synthesized and structurally characterized in order to examine the ring extension effect on the known derivative, 2,2-diphenyl-1,2- dihydroquinoline-N-oxyl (1). Based on SQUID measurement, 2 exhibited a ferromagnetic interaction obeying the Bleaney-Bowers equation with 2J = +4.6 cm -1. The X-ray analysis revealed an intermolecular edge-edge association of the aryl ring and N-oxyl moiety in the crystal of 2. The bifurcated edge-edge contacts between the α-spin site (nitroxyl O atom) and the β-spin site (aryl-H atoms) are responsible for the ferromagnetic interaction of 2.. AB - A novel stable organic radical, 2,2-diphenyl-1,2-dihydrobenzo[g]quinoline- N-oxyl ...
To name compounds containing phenyl groups, the phenyl group can be taken to be the parent hydrocarbon and being represented by the suffix -benzene. Alternatively, the phenyl group could be treated as the substituent, being described within the name as phenyl. This is usually done when the group attached to the phenyl group consists of six or more carbon atoms.[3]. As an example, consider a hydroxyl group connected to a phenyl group. In this case, if the phenyl group was taken as the parent hydrocarbon, the compound would be named hydroxybenzene. Alternatively, and more commonly, the hydroxyl group could be taken as the parent group (and the phenyl group treated as the substituent), resulting in the more familiar name phenol. ...
Maybe its a dubious distinction, but it is rather exciting to know we live in one of the most naturally dangerous places in the world (and a more dangerous place than our sister tech city in.
Selective activation of some dihydrodiols of several polycyclic aromatic hydrocarbons to mutagenic products by prostaglandin synthetase.: The ability of prostag
The city of Tampa[http://www.visittampabay.com/] in Hillsborough County is the largest city in the greater Tampa Bay region of Florida, which has a combined population of 2.5 million.
As the only hospital located in Inglewood, California, Centinela Hospital Medical Center is known for its exceptional expertise and care. Each year, the hospital serves more than 140,000 patients and their families from Los Angeles and the South Bay regions.. ...
How one woman transformed the marshy, wooded Chesapeake Bay region, first a gateway through which slave traders brought Africans, into a route to liberation.
The K-region trans-5,6-dihydrodiols formed in the metabolism of 12-methylbenz[a]anthracene (12-MBA) by liver microsomal preparations from untreated, phenobarbital-treated and 3-methylcholanthrene-treated male Sprague-Dawley rats were found by chiral stationary-phase h.p.l.c. (c.s.p.-h.p.l.c.) analyses to contain (5S,6S)/(5R,6R) enantiomer ratios of 93:7, 88:12 and 97:3 respectively. The absolute stereochemistry of a 12-MBA trans-5,6-dihydrodiol enantiomer was elucidated by the exciton-chirality c.d. method. The 5,6-epoxides formed in the metabolism of 12-MBA by liver microsomal preparations from untreated, phenobarbital-treated and 3-methylcholanthrene-treated male Sprague-Dawley rats in the presence of the epoxide hydrolase inhibitor 3,3,3-trichloropropylene 1,2-oxide were isolated from a mixture of metabolites by normal-phase h.p.l.c., and their (5S,6R)/(5R,6S) enantiomer ratios were found by c.s.p.-h.p.l.c. analyses to be 73:27, 78:22 and 99:1 respectively. The absolute configurations of ...
Kerryn Pollock, Hawkes Bay region - Society, Te Ara - the Encyclopedia of New Zealand, http://www.TeAra.govt.nz/en/zoomify/23946/social-deprivation (accessed 17 September 2021). Story by Kerryn Pollock, updated 1 Jul 2015. ...
Everywhere you turn in October companies are Pinkwashing us by claiming to be in support of breast cancer research while using ingredients that are mammary carcinogens, or carcinogenic contaminants that behave as endocrine disrupting compounds in our bodies, causing hormonal imbalance. As the Gerson Institute calls it, carcinogens for the cure. True that. Pinkwashing - verb 1. the sale of items containing known carcinogens, while marketing these products in support of breast cancer awareness 2. also, capitalizing on the promotion of breast cancer prevention when only concerned about bottom line profit margin.. Its said that Evelyn Lauders dream was to end breast cancer. Why doesnt the company jump off the breast cancer awareness bandwagon and honor her memory by reformulating their products WITHOUT harmful cancer causing ingredients?! LOreal, Proctor & Gamble and many others do it too. How do they sleep at night?!. According to the Breast Cancer Fund, which is doing amazing work in the ...
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The state reported 5,885 new positive coronavirus cases and 42 new deaths. The Tampa Bay region reported four new deaths in Wednesdays report.
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for (1E)-?1,1(3H,3H)-Bi[benzo[c]thiophene]-3,3-dione (CAS No. 23667-32-5)
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Read about the chemical and physical properties of 5-((Z)-2-Bromo-vinyl)-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione. Get 5-((Z)-2-Bromo-vinyl)-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
3beta,5-dihydroxy-1-N-methyl-indoline-2beta-carbonyl amino-D-alanyl-erythro-beta-hydoxyisoleucinyl-glycine: indolinepeptide from Paecilomyces sp. J300; structure in first source
What are the hours of work? ,a href= http://royal-golf-park.com/bactrim-coverage-group-b-strep/ ,bactrim ds 800 160,/a, They are often dressed in hand-me-downs, and the ones propped up outdoors lined with plastic to keep them dry ...
Three Clar structures with two sextets each are present in the four-ring chrysene structure: one having sextets in the first ...
22-. ISBN 978-0-299-10480-1. Wilds AL, Sutton RE (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of ... Tetrahydrochrysene Chrysene Triphenylethylene Estrobin Stilbestrol Methallenestril Ethamoxytriphetol Maximov PY, McDaniel RE, ...
Picine and chrysene as constituents of the mineral Curtisite (idrialite)". Experentia, volume 23, pages 793-794. Thomson, ... chrysene, and their methyl- and dimethyl-substituted homologues; the major components in the idrialite sample were higher- ...
CO2 1-hydroxy-2-naphthoate hydroxylase is involved in chrysene degradation in some bacteria. Deveryshetty J, Phale PS (October ... "A catabolic pathway for the degradation of chrysene by Pseudoxanthomonas sp. PNK-04". FEMS Microbiology Letters. 320 (2): 128- ...
predict that at least three more PAH crystals (pyrene, chrysene and tetracene) should occur as minerals. There are 72 known ... Others are mixtures: curtisite contains several PAH compounds, including dibenzofluorine, picene, and chrysene, while the most ...
One of these compounds, chrysene, was present at levels higher than the standard established by OEHHA. Chrysene is a known ...
The sediment was found to contain arsenic, a number of Polycyclic aromatic hydrocarbons, cadmium, and chrysene. "Michigan ...
2,8-DHHHC Chrysene Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS (1999). "Novel ligands that ...
... chrysene) Glucuronidation by UDP-Glucuronosyltransferases". Chemical Research in Toxicology. 24 (9): 1549-59. doi:10.1021/ ...
... phenanthrene and chrysene. Benzene is known to be a human carcinogen, and is detected most frequently and at the greatest ...
8-DHHHC Chrysene Ying Chen (2008). The Role of Steroids in the Regulation of Oocyte Cyst Breakdown and Primordial Follicle ...
It is well known that both kinked phenanthrene and chrysene are around 6 kcal/mol (25 kJ/mol) more stable than their linear ... The theory is also applied to so-called hydrogen-hydrogen bonds as they occur in molecules such as phenanthrene and chrysene. ...
Ionkin, A. S.; Marshall, W. J.; Fish, B. M.; Bryman, L. M.; Wang, Y. (2008). "A tetra-substituted chrysene: orientation of ... multiple electrophilic substitution and use of a tetra-substituted chrysene as a blue emitter for OLEDs". Chem. Commun. (20): ...
... chrysene". Cancer Research. 58 (23): 5340-5343. ISSN 0008-5472. PMID 9850062. v t e. ...
Being a fully benzenoid PAH means that triphenylene is much more resonance stable than its isomers chrysene, benz[a]anthracene ...
The compound was originally synthesized by Erich Clar in 1955 from acenaphthene in one method and from chrysene in another. ...
... chrysenes MeSH D04.615.723.590 - diterpenes, abietane MeSH D04.615.799.306 - benzopyrenes MeSH D04.615.799.306.300 - benzo(a) ...
Chrysene Record of CAS RN 85-01-8 in the GESTIS Substance Database of the Institute for Occupational Safety and Health Peter ...
In June 2016, BaP was added as benzo[def]chrysene to the REACH Candidate List of Substances of very high concern for ...
... parent compound of steroidal estrogens like estradiol Chrysene - parent compound of a group of nonsteroidal weak estrogens that ...
Chemicals such as chrysene, benzo(a)pyrene, benzo(e)pyrene, benzene and others are now on the restricted chemicals Candidate ...
Chrysene 1925 - Kongoni 1924 - Jolly Odd 1923 - Lace Girl 1922 - †His Double / Honneur 1921 - Yanda 1920 - Easingwold 1919 - ...
... chrysene Benzo[a]fluoranthene Benzo[ghi]fluoranthene Benzo[a]fluorene Benzo[b]fluorene Benzo[c]fluorene Benzo[ghi]perylene ... metallic Chrysene Chrysoidine CI Acid Orange 3 Cimetidine Cinnamyl anthranilate CI Pigment Red 3 Citrinin Clofibrate Clomiphene ... chrysene 5,6-Cyclopenteno-1,2-benzanthracene D & C Red No. 9 Dapsone Decabromodiphenyl oxide Deltamethrin ...
The molecular formula C18H12 may refer to: Benz[a]anthracene, or benzo[a]anthracene Benzo[c]phenanthrene Chrysene Tetracene, ...
... chrysene, and benzo(c)phenathrene). This data shows that myricetin is not unilaterally able to reduce the carcinogenic activity ...
... such as chrysene and benzo(a)pyrene. A strain of R. taiwanensis was shown to grow at constant gamma radiation 66 Gy/h at pH 2.3 ...
... chrysene, dibenz(a,h)anthracene, and indeno(1,2,3-cd)pyrene. Pathogens are bacteria and viruses that can be found in water and ...
... chrysene, fluoranthene, pyrene, triphenylene, naphthacene, benzanthracene, 5-rings: picene, benzo[a]pyrene, benzo[e]pyrene, ...
BjF can be obtained when either 2-(1-chloroethenyl)benzo[c]phenanthrene or 6-(1-chloroethenyl)chrysene is treated by flash ...
Chrysene is a constituent of tobacco smoke. As with other PAHs, chrysene is suspected to be a human carcinogen. Some evidence ... Chrysene is estimated to have about 1% of the toxicity of benzo(a)pyrene. Derivatives of chrysene include tetrahydrochrysene ... However, high purity chrysene is colorless, the yellow hue being due to the traces of its yellow-orange isomer tetracene, which ... The name "chrysene" originates from Greek Χρύσoς (chrysos), meaning "gold", and is due to the golden-yellow color of the ...
Special Occupational Hazard Review and Control Recommendations for Chrysene ... Special Occupational Hazard Review and Control Recommendations for Chrysene. ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Chrysene. Regulatory process names 2 Translated names 17 IUPAC names 2 Other names 1 Other identifiers 3 ...
Benzo[def]chrysene. ↓Other names: Regulatory process names [5] Other names [1] IUPAC names [7] ...
... accessment of chrysene in sediment (unsieved) at station Clyde_FirthCInnerCumbraes_se02, Skelmorlie (Clyde) from the Marine ... CSEMP assessment of chrysene in sediment at Skelmorlie (Clyde). Statistical analysis. Trend assessment. Analysis of variance. ... Determinand : Chrysene. Units : μg kg-1 dry weight normalised to 2.5% organic carbon. Data extraction : 30 April 2020. ...
... accessment of chrysene in biota (blue mussel soft body) at station Forth_LowerForthEstuary_sh01 (Forth estuary @ Blackness) ... CSEMP assessment of chrysene in biota at Forth estuary @ Blackness. Statistical analysis. Trend assessment. Analysis of ... Determinand : Chrysene. Units : μg kg-1 wet weight. Data extraction : 30 April 2020. ...
0.5 for Chrysene 250, 500, 750 and 1000µM respectively. ROS activity was significantly increased for all chrysene ... Effects Of Chrysene On Human Arpe-19 Cells You will receive an email whenever this article is corrected, updated, or cited in ... Conclusions: : Chrysene in all concentrations used in this study significantly decreases retinal cell viability in vitro, ... Results: : ARPE-19 cells treated with chrysene mean % CV was 93.65%, 81.10%, 77.55% and 60.05% for 250, 500, 750 and 1000 µM ...
Dibenzo Def, Mno Chrysene-6,12-Dione, 4,10-Dibromo-. Identifications. *CAS Number: 4378-61-4*Synonyms/Related:*Dibenzo Def, Mno ... Chemical Database - Dibenzo Def, Mno Chrysene-6,12-Dione, 4,10-Dibromo-. EnvironmentalChemistry.com. 1995 - 2018. Accessed on- ... Mno Chrysene-6,12-Dione, 4,10-Dibromo- (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Dibenzo ... Chrysene-6,12-Dione, 4,10-Dibromo- Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An online version of the ...
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; Benzo[a]pyrene; Dibenzo[def,p]chrysene; Polycyclic aromatic ... Title: In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic ... Accepted Manuscript: In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and ... The prototypic PAH, benzo[a]pyrene (B[a]P) and the highly carcinogenic dibenzo[def,p]chrysene (DBC) are metabolically activated ...
Benzo[def]chrysene (Benzo[a]pyrene). EC No.: 200-028-5 CAS No.: 50-32-8 ...
The mean of the chrysene-DE adducts in smokers was estimated to be 310 +/- 30 SE fmol/mg globin (ranging from 190 to 460 fmol/ ... Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans.. A A ... Levels of trans-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (chrysene-DE)-globin adducts were estimated by assuming that ... Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans. ...
0/Carcinogens; 0/Chrysenes; 0/Pyrenes; 129-00-0/pyrene; 218-01-9/chrysene; 50-32-8/Benzo(a)pyrene; 51-79-6/Urethane; 57-97-6/9, ... Chrysenes / toxicity. Mice. Mice, Hairless. Micronucleus Tests / methods*. Pyrenes / toxicity. Skin / cytology, drug effects*. ... Micronuclei in mouse skin cells following in vivo exposure to benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, chrysene, pyrene ... Dose-dependent increases in MN were observed with DMBA, benzo[a]pyrene, chrysene, and urethane. Increased numbers of ...
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual ... Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response ... chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring, Cancer Letters (2011), doi: ...
Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP ... Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP- ... Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP- ... Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP- ...
Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.
... chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a] pyrene (BAP), dibenz[a.,h] anthracene (DAHA), benzo[ghi]perylene ...
Dibenzo[def,p]chrysene (DBC) is a high molecular weight PAH classified as a 2B carcinogen by the International Agency for ... Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. ... Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice.. ...
... chrysene diol epoxide isomers. Together they form a unique fingerprint. * benzo(c)chrysene Chemical Compounds ... chrysene (B[c]C). The catalytic efficiency (k(cat)/K(m)) of V104,A113 (VA) and V104,V113 (VV) variants of hGSTP1-1 was ... chrysene (B[c]C). The catalytic efficiency (k(cat)/K(m)) of V104,A113 (VA) and V104,V113 (VV) variants of hGSTP1-1 was ... chrysene (B[c]C). The catalytic efficiency (k(cat)/K(m)) of V104,A113 (VA) and V104,V113 (VV) variants of hGSTP1-1 was ...
Search 5-Methyl Chrysene Synthesis route and MSDS, CAS 3697-24-3 Synthesis Route and NMR Spectrum, 3697-24-3 Precursor and ...
Chrysene. 0.12 ppb. 0.48. -. -. 2. 1. 0. 0 No. Dibromochloromethane. 0.10 ppb. 0.57. 60. 80. 3. 1. 0. 0 Yes. ...
Three Clar structures with two sextets each are present in the four-ring chrysene structure: one having sextets in the first ...
218-01-9.................................. Chrysene. 287-92-3.................................. Cyclopentane. 297-78-9 ...
Californias Prop 65 and Chrysene Public Health Concerns In 1986, California voters approved an initiative to address ...
Benz[a]pyrene ; BaP ; Benzo[d,e,f]chrysene ;Benzo[a]pyrene ; 3,4-Benzpyrene (carcinogen) ; 3,4-Benzopyrene ; 6,7-Benzopyrene ; ...
chrysene; Nickel; diethylphthalate; methylphenol; endrin; phenanthrene; barium; di-N-octyl phthalate; Dichloroethylene; ...
6) "Confirmation" means an additional sample is analyzed from the same location where a detection has occurred to confirm the detection. The original sample and the confirmation sample are collected and analyzed within a reasonable period of time, generally not to exceed two weeks. Confirmation occurs when the confirmation sample analysis result falls within plus or minus thirty percent of the original sample result. This confirmation analysis is in addition to any analytical method confirmation requirements ...
chrysene^. Vinggaard et al., 2000 [110]. Monteiro et al., 2000a [111]; Monteiro et al., 2000b [114] ...
TEFs for chrysene, benzo[k]fluoranthene, benz[a]anthracene, indeno[1,2,3-cd]pyrene, benzo[b]fluoranthene, and dibenz[a,h] ... For the cancer evaluation (chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benz(a)anthracene, indeno(1,2,3-cd)pyrene, ... chrysene, benzo(k)fluoranthene, benzo(b)fluoranthene, benz(a)anthracene, indeno(1,2,3-cd)pyrene, dibenz(a,h)anthracene or benzo ...
  • Chrysene is estimated to have about 1% of the toxicity of benzo(a)pyrene. (wikipedia.org)
  • Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans. (aacrjournals.org)
  • The efficacy of a newly developed gas chromatography-negative ion chemical ionization-mass spectrometry-selected ion monitoring (GC-NICI-MS-SIM) assay for measuring globin adducts of benzo[a]pyrene (B[a]P) and chrysene diol epoxides in human was evaluated. (aacrjournals.org)
  • Micronuclei in mouse skin cells following in vivo exposure to benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, chrysene, pyrene and urethane. (biomedsearch.com)
  • Dose-dependent increases in MN were observed with DMBA, benzo[a]pyrene, chrysene, and urethane. (biomedsearch.com)
  • Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1). (aspetjournals.org)
  • Mono- and diphenols of chrysene and benzo(a)pyrene are suspected substrates of a 3-methylcholanthrene (MC)-inducible phenol UDP-glucuronosyltransferase (UGT1A1). (aspetjournals.org)
  • The present invention provides a benzo[b]chrysene compound represented by general formula [1] below and an organic light-emitting element including the compound. (patentsencyclopedia.com)
  • [0002] The present invention relates to a novel benzo[b]chrysene compound and an organic light-emitting element including the same. (patentsencyclopedia.com)
  • [0006] One of the polycyclic aromatic hydrocarbons is benzo[b]chrysene. (patentsencyclopedia.com)
  • No. 7,183,010 discloses 2,3-benzochrysene as compound 444 which is an unsubstituted benzo[b]chrysene as an example of associated compounds in organic light-emitting elements using excimer emission due to molecular association. (patentsencyclopedia.com)
  • A structural formula of benzo[b]chrysene is shown below. (patentsencyclopedia.com)
  • 1980,45,1424 (p. 1427, lower right) discloses a method for synthesizing a benzo[b]chrysene compound having an aryl substituent only at the 5-position, i.e., 5-(2-naphthyl)benzo[b]chrysene, and physical property values thereof. (patentsencyclopedia.com)
  • A structural formula of the benzo[b]chrysene compound having an aryl substituent only at the 5-position is shown below. (patentsencyclopedia.com)
  • [0008] An object of the present invention is to provide a novel compound exhibiting satisfactory luminescence, more specifically a novel benzo[b]chrysene compound. (patentsencyclopedia.com)
  • The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. (openrepository.com)
  • Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. (openrepository.com)
  • The strain grew on phenanthrene as a sole carbon and energy source and could mineralize 14 C from a number of partially labeled PAHs, including naphthalene, phenanthrene, chrysene, benz[ a ]anthracene, and benzo[ a ]pyrene, but not pyrene or fluoranthene. (asm.org)
  • None of the tested RHDs were capable of significantly transforming fluoranthene, chrysene, or benzo[ a ]pyrene. (asm.org)
  • In the sample fractions, only one had any measurable aromatic hydrocarbons, which consisted of 0.00023mg/m3 fluoranthene (206440), 0.00134mg/m3 pyrene (129000), and 0.00053mg/m3 chrysene (218019). (cdc.gov)
  • Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. (oregonstate.edu)
  • Dibenzo[def,p]chrysene (DBC) is a high molecular weight PAH classified as a 2B carcinogen by the International Agency for Research on Cancer. (oregonstate.edu)
  • Some evidence suggests that it causes cancer in laboratory animals, but chrysene is often contaminated with more strongly carcinogenic compounds. (wikipedia.org)
  • Derivatives of chrysene include tetrahydrochrysene and 2,8-dihydroxyhexahydrochrysene, which are estrogenic compounds. (wikipedia.org)
  • As with other PAHs, chrysene is suspected to be a human carcinogen. (wikipedia.org)
  • Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C 18H 12 that consists of four fused benzene rings. (wikipedia.org)
  • To evaluate the in vitro toxicity of chrysene on human retinal pigment epithelial cells (ARPE-19). (arvojournals.org)
  • Toxicity for the chrysene solvent DMSO was tested for all treatment groups and no statistically significant change was seen. (arvojournals.org)
  • However, high purity chrysene is colorless, the yellow hue being due to the traces of its yellow-orange isomer tetracene, which cannot be separated easily. (wikipedia.org)
  • The directional reactive model was applied to predict variation of aryl hydrocarbon receptor-mediated toxic potencies among homologues of chrysene with structural modifcations such as the numbers of constituent benzene rings, methylation and hydroxylation. (kist.re.kr)
  • After 24 hours of chrysene exposure, the following assays were performed: trypan blue dye exclusion to measure cell viability (CV), JC-1 to measure changes in mitochondrial membrane potential (ΔΨM), caspase-3/7 as an indicator of apoptotic activity and the 2', 7' dichlorodihydrofluorescein diacetate (DCFH-DA) assay to measure accumulation of reactive oxygen species (ROS). (arvojournals.org)
  • ARPE-19 cells treated with chrysene mean % CV was 93.65%, 81.10%, 77.55% and 60.05% for 250, 500, 750 and 1000 µM respectively, the later showed significantly reduction in CV% compared to untreated ARPE19 controls. (arvojournals.org)
  • ROS activity was significantly increased for all chrysene concentrations when compared to untreated control. (arvojournals.org)
  • Caspase 3/7 activity was significantly increased for all chrysene concentrations. (arvojournals.org)
  • Chrysene in all concentrations used in this study significantly decreases retinal cell viability in vitro, induces JC1, ROS, and caspase 3/7 activity. (arvojournals.org)
  • Levels of trans-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (chrysene-DE)-globin adducts were estimated by assuming that the recovery and the MS response of the perdeuterated B[a]P-tetraol internal standard reflected the recovery and MS response of chrysene tetraols. (aacrjournals.org)
  • Interestingly, estimated levels of chrysene-DE-globin adducts in the same subjects were about two orders of magnitude higher than those of the globin adducts of BPDE. (aacrjournals.org)
  • The detection limits were fairly high, exceeding measured levels in some cases (e.g., chrysene), and more problematic, exceeding some health-based reference values (e.g., methylene chloride). (albany.edu)
  • chrysene decreased IsoP levels. (aacrjournals.org)