The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
The adaptation of drug administration to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
A progressive advance or delay of bedtime until the desired bedtime is achieved.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (1/56)

AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin.  (+info)

Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration. (2/56)

Temporal variations in the renal toxicity of aminoglycosides have been reported for experimental animals as well as for humans. In fact, maximal renal toxicity of aminoglycosides was observed when the drug was given during the rest period, while a lower toxicity was observed when the drug was injected during the activity period. The aim of the present study was to evaluate temporal variations in the effectiveness and renal toxicity of gentamicin in an experimental model of pyelonephritis in rats. The experiments were carried out with female Sprague-Dawley rats (185 to 250 g). They had free access to food and water throughout the study and were maintained on a 14-h light-10-h dark cycle. Animals were divided into four groups corresponding to the respective time of induction of pyelonephritis and treatment: 0700, 1300, 1900, and 0100 h. Pyelonephritis was induced by a direct inoculation of Escherichia coli (10(7) to 10(8) CFU) in the left kidney. Animals were treated for 3 and 7 days with a single daily dose of gentamicin (20 and 40 mg/kg of body weight, respectively) or saline (NaCl, 0.9%) at either 0700, 1300, 1900, or 0100 h. Animals treated at 0100 h for 3 days with gentamicin (20 mg/kg) showed a significantly lower number of bacteria in their kidneys than did all other groups (P < 0.01). After 7 days of treatment, the efficacy, evaluated by the log CFU per gram of tissue and by the percentage of sterilized kidneys, was also higher when gentamicin was administered at 0100 h. The beta-galactosidase and the N-acetyl-beta-D-glucosaminidase activities were significantly higher in urine of rats given gentamicin at 1300 h than in urine of rats treated at another time of day (P < 0.05). Gentamicin injected at 1300 h induced a significantly greater increase of [3H]thymidine incorporation into DNA of renal cortex (P < 0.01), a significantly greater inhibition of sphingomyelinase activity (P < 0.05), and significantly more histopathological lesions than the same dose injected at another time of the day. Creatinine and blood urea nitrogen levels in serum were significantly higher (P < 0.05) and the creatinine clearance was significantly lower (P < 0.05) when gentamicin was injected at 1300 h than when it was injected at another time of day. Our data suggest temporal variations in both the toxicity and the effectiveness of gentamicin, the drug being more effective and less toxic when injected during the activity period of the animals.  (+info)

High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion. (3/56)

The purpose of the study was to examine inter- and intrapatient variation in 5-fluorouracil (5-FU) plasma concentrations in adult cancer patients receiving a 3-day drug infusion. Fourteen patients received 1266 mg/m2 N-(phosphonacetyl)-L-aspartate (PALA) infused i.v. over 15 min on day 1, followed immediately by a loading dose of 500 mg/m2 calcium leucovorin over 30 min. Then a prolonged infusion of leucovorin at 500 mg/m2/day and 5-FU at 1750 mg/m2/day was administered as either a constant rate or as a circadian infusion over 72 h. During constant rate infusions, 5-FU concentrations within individuals varied by 1.7-fold, but no uniform time of peak or trough concentration was observed. Transformation of these data by setting the time of peak to 0 h and by expressing concentrations as the percentage of the 24-h mean value revealed a nonrandom distribution of the time from peak to trough with a median time of 12 h (P = 0.027). These transformed data were also successfully fit to a circadian cosinor function (P < 0.001). During multiple constant rate 5-FU infusions, the intrapatient variability was high; the times of peak 5-FU concentration occurred at the same approximate sampling time 43% of the time, and troughs coincided 17% of the time. No difference in clinical toxicity was observed when matched constant rate and circadian infusions of 5-FU were compared. High inter- and intrapatient variability exists in 5-FU plasma concentrations in adult cancer patients during constant rate infusions with no evidence of a consistent circadian rhythm in untransformed data.  (+info)

Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. (4/56)

CONTEXT: Long-term survival of patients with metastatic colorectal cancer has been achieved only in patients who underwent complete resection of metastases. Such surgery could be performed in a greater proportion of patients if effective chemotherapy could downstage previously unresectable metastases. This approach has been limited by the low tumor response rate achieved with conventional chemotherapy. OBJECTIVE: We studied the outcome of patients with initially unresectable liver metastases from colorectal cancer treated with a three-drug chemotherapy regimen followed by liver metastases surgery whenever possible. PATIENTS AND METHODS: From March 1988 to June 1994, 151 patients with colorectal liver metastases were considered initially unresectable because of large tumor size (> 5 cm), multinodular (> 4) or ill-located metastases. All patients received fully ambulatory chemotherapy with 5-fluorouracil, leucovorin and oxaliplatin (chronotherapy in 83% of them). They were periodically reassessed for surgery by a joint medico-surgical team. RESULTS: In 151 patients, the size of liver metastases decreased by > 50% in 89 patients (59%) and median overall survival was 24 months (95% confidence interval (95% CI): 19-28 months), with 28% surviving at five years (20%-35%). Surgery with curative intent was attempted in 77 patients (51%), complete resection of liver metastases was achieved in 58 patients (38%). The median survival of the 77 operated patients was 48 months (25-71), with a five-year survival rate of 50% (38-61). CONCLUSION: This new strategy of combining effective chemotherapy with surgery apparently altered the natural history of unresectable colorectal cancer metastases.  (+info)

Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. (5/56)

PURPOSE: To study how adding oxaliplatin (l-OHP) to chronomodulated fluorouracil (5-FU)-leucovorin (LV) affected the objective response rate, as first-line treatment of metastatic colorectal cancer. PATIENTS AND METHODS: Two hundred patients from 15 institutions in four countries were randomly assigned to receive a 5-day course of chronomodulated 5-FU and LV (700 and 300 mg/m(2)/d, respectively; peak delivery rate at 0400 hours) with or without l-OHP on the first day of each course (125 mg/m(2), as a 6-hour infusion). Each course was repeated every 21 days. Response was assessed by extramural review of computed tomography scans. RESULTS: Grade 3 to 4 toxicity from 5-FU-LV occurred in +info)

Biological time and in vivo research: a field guide to pitfalls. (6/56)

Biological rhythmicity is a fundamental characteristic of all life forms, from primitive bacteria to man. The molecular biology, genetics, and the neurobiology of the biological clock(s) are being elucidated. Daily (circadian) statistically significant fluctuations occur in all of the normal biological variables studied in the experimental animal and the human. Many researchers, however, are not aware of the negative impact biological rhythmicity can have on experimental design and/or data interpretation. This article serves not as a review, but as a "field guide" to the pitfalls that can occur when research is performed in the absence of an understanding of biological rhythmicity. The major topics discussed are: 1) data transfer from the diurnally in-active/resting/sleeping lab animal to the diurnally active human, 2) frequency of sampling, 3) free-running vs. synchronization, 4) alternating periods of resistance and susceptibility, 5) phase shifting of a rhythm, 6) the assumption that one mean +/- S.E. from control animals can be "stretched" across an experimental time span, and 7) plotting data on an "hours after treatment" format vs. a "time of day" format. The hope is that by avoiding the pitfalls, biological time will become an ally in the endeavor to understand human biology.  (+info)

Chronotherapeutic delivery of verapamil in obese versus non-obese patients with essential hypertension. (7/56)

BACKGROUND: The effect of controlled-onset, extended-release (COER) verapamil on haemodynamic parameters in obese and non-obese patients is evaluated in this analysis. METHODS: Data were pooled from three clinical trials evaluating efficacy and tolerability of COER-verapamil. Hypertensive men and women (stage I to III) were randomised to COER-verapamil (180-540 mg at bedtime) or placebo for 4-8 weeks and stratified according to body mass index (BMI-obese > 28 kg/m2). Efficacy was assessed as change from baseline in blood pressure (BP), heart rate, and rate-pressure product during four time periods throughout the dosing interval. Safety and tolerability were assessed by monitoring all adverse events and changes in metabolic laboratory parameters. RESULTS: Reductions in all haemodynamic parameters were significantly greater following COER-verapamil compared with placebo for all time periods. The haemodynamic effects of COER-verapamil in obese (n = 166, BMI = 32.8 kg/m2) and non-obese patients (n = 115, BMI = 25.0 kg/m2) were similar. COER-verapamil was well tolerated in both subgroups, but the incidence of constipation was significantly less in obese patients (P < 0.001). CONCLUSIONS: COER-verapamil is effective in reducing BP, heart rate, and rate-pressure product independently of BMI.  (+info)

Weekly docetaxel in breast cancer: applying clinical data to patient therapy. (8/56)

The use of weekly 35-40 mg/m2 docetaxel, typically on a schedule of 6 weeks of therapy followed by a 2-week break, has produced response rates ranging from 33%-50% in patients with advanced breast cancer, the majority of whom have already received chemotherapy. These encouraging levels of response are seen across disease sites and in patients with prior anthracycline exposure. Importantly, the weekly administration of docetaxel allows prolonged treatment to a high cumulative dose: the weekly regimen is minimally myelotoxic, and neuropathy and other adverse events are infrequent. Weekly single-agent docetaxel may be a useful therapy in particular groups of patients such as those with reduced bone marrow reserve. It may also be a helpful means of delivering a highly active cytotoxic drug in combination with radiation therapy, other proven chemotherapy agents such as doxorubicin, and new, highly promising biological agents such as HERCEPTIN:  (+info)

Chronotherapy is a medical treatment strategy that involves adjusting the timing of medication or other treatments based on the body's internal clock or circadian rhythms. The goal of chronotherapy is to optimize the effectiveness and minimize the side effects of treatments by administering them at specific times when they are most likely to be beneficial and well-tolerated.

For example, certain medications may be more effective when given at night because the body's metabolism slows down during sleep, allowing the drug to remain in the system longer. Similarly, some cancer treatments may be more effective when administered in the morning or evening based on the patient's circadian rhythms.

Chronotherapy can also involve adjusting lifestyle factors such as diet, exercise, and light exposure to help regulate the body's internal clock and improve overall health. This approach has been shown to be effective in treating a variety of conditions, including insomnia, depression, asthma, and cardiovascular disease.

Drug chronotherapy is a medical approach that involves the administration of medication at specific times or schedules to coincide with the body's circadian rhythms, with the aim of optimizing therapeutic efficacy and minimizing side effects. This strategy takes advantage of the fact that many physiological processes, including drug metabolism and elimination, exhibit daily variations due to the internal biological clock. By aligning drug administration with these natural rhythms, healthcare providers can potentially enhance treatment outcomes and improve patient compliance.

Examples of drug chronotherapy applications include:
- Administering anti-inflammatory drugs in the evening for patients with rheumatoid arthritis to reduce morning stiffness and pain
- Giving chemotherapeutic agents at specific times to maximize tumor cell kill and minimize toxicity to normal tissues
- Timing corticosteroid doses to match the natural circadian variation in endogenous cortisol production, which may help reduce side effects and improve efficacy

It is important to note that successful implementation of drug chronotherapy requires a thorough understanding of each patient's individual circadian rhythm patterns and potential interactions between drugs and the biological clock.

Chronobiology is the study of biological rhythms and their synchronization with environmental cycles. It examines how various biological processes in living organisms, including humans, are regulated by endogenous (internal) and exogenous (external) factors that recur over a specific time period. These rhythmic phenomena are known as circadian, ultradian, and infradian rhythms.

Circadian rhythms have a periodicity of approximately 24 hours and regulate many physiological processes such as sleep-wake cycles, body temperature, hormone secretion, and metabolism. Ultradian rhythms are shorter than 24 hours and include processes like heart rate variability, brain wave activity during sleep, and digestive enzyme release. Infradian rhythms have a longer periodicity, ranging from days to years, and include menstrual cycles in women and seasonal variations in animals.

Chronobiology phenomena are crucial for understanding the timing of various physiological processes and how they can be influenced by external factors like light-dark cycles, social cues, and lifestyle habits. This knowledge has applications in fields such as medicine, agriculture, and environmental science.

Sleep phase chronotherapy is a specialized treatment approach in sleep medicine that involves systematically adjusting a person's sleep and wake times to realign their circadian rhythm (internal biological clock) with their desired sleep-wake schedule. This technique is often used to treat circadian rhythm sleep disorders, such as delayed sleep phase disorder (DSPD), advanced sleep phase disorder (ASPD), and irregular sleep-wake rhythm disorder.

The process of sleep phase chronotherapy typically involves gradually shifting the sleep onset time earlier or later in small increments (usually 15-60 minutes) every one to three days until the desired sleep schedule is achieved. This adjustment can be done over a period of several weeks, depending on the severity and nature of the sleep disorder.

It's important to note that sleep phase chronotherapy should be conducted under the supervision of a qualified healthcare professional or sleep specialist, as improper implementation may lead to further disruption of the circadian rhythm and exacerbate existing sleep problems.

A circadian rhythm is a roughly 24-hour biological cycle that regulates various physiological and behavioral processes in living organisms. It is driven by the body's internal clock, which is primarily located in the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain.

The circadian rhythm controls many aspects of human physiology, including sleep-wake cycles, hormone secretion, body temperature, and metabolism. It helps to synchronize these processes with the external environment, particularly the day-night cycle caused by the rotation of the Earth.

Disruptions to the circadian rhythm can have negative effects on health, leading to conditions such as insomnia, sleep disorders, depression, bipolar disorder, and even increased risk of chronic diseases like cancer, diabetes, and cardiovascular disease. Factors that can disrupt the circadian rhythm include shift work, jet lag, irregular sleep schedules, and exposure to artificial light at night.

The safety of chronotherapy is not fully known. While chronotherapy has been successful for some, it is necessary to rigidly ... In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person ... Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New ... A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ...
Chronotherapy, also called chronotherapeutics or chronotherapeutic drug delivery, refers to the coordination of therapeutic ... In the treatment of psychiatric conditions including bipolar depression, a form of chronotherapy combining intermittent sleep ...
Dridi D, Zouiten A, Mansour HB (June 2013). "Depression: chronophysiology and chronotherapy". Biological Rhythm Research. 45: ...
Phase delay chronotherapy is also occasionally used. Melatonin taken at night will not change the individual's circadian rhythm ... FASP is traditionally treated with light therapy in the evenings, or behaviorally with chronotherapy. Individuals with FASP ...
Several other cases have been preceded by chronotherapy, a prescribed treatment for delayed sleep phase disorder. "Studies in ... Oren, Dan A.; Wehr, Thomas A. (December 10, 1992). "Hypernyctohemeral syndrome after chronotherapy for delayed sleep phase ... a hypernyctohemeral syndrome could occur as a physiologic aftereffect of lengthening the sleep-wake cycle with chronotherapy". ...
"Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy". International Journal of Molecular ...
Roy, Sree (28 October 2014). "New Study Makes Strides in Chronotherapy, Details Gene Oscillations in Mammals". Sleep Review. ... First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery and Emerging Field of Chronotherapy: Penn ... Hogenesch's discovery that many proteins targeted by drugs experience circadian fluctuations made strides towards chronotherapy ...
A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ... phase delay chronotherapy, is intended to reset the circadian clock by manipulating bedtimes. It consists of going to bed two ...
Biological rhythm Chronotherapy (treatment scheduling) Circadian rhythm Mood ring Clark Glymour, Douglas Stalker (1990). " ...
Chronotherapy has also been prescribed for circadian rhythm disorders, though results are generally short-lived. Stimulants may ...
... and the first RCT on triple chronotherapy in out-patients with depression (Veale et al. 2021). Keyes, A.; Veale, D. (2021). ...
Terman M, McMahan I (2012) Chronotherapy: Resetting Your Inner Clock to Boost Mood, Alertness, and Quality Sleep. New York, ...
... time using certain biomarkers found in human blood can improve diagnosis of circadian disorders and optimize chronotherapy. In ...
Implementing a personalized signature-based platform for chronotherapy". Obesity Reviews. 22 (2): e13108. doi:10.1111/obr.13108 ...
Chronotherapy is sometimes used as a treatment, as an attempt to alter the phase of the individual's clock using cycles of ...
... chronotherapy and chronorecord-keeping. 'We pay more attention to watches we wear on our wrists than to clocks we acquire in ... A review in The Baltimore Sun quoted Lamberg's example explaining chronotherapy: "A drug like aspirin stays in the body for a ...
Once diagnosed, ASPD may be treated with bright light therapy in the evenings, or behaviorally with chronotherapy, in order to ...
Another type of therapy used in individuals with PBD is chronotherapy, which helps children and adolescents form a healthy ...
... including Advanced sleep phase disorder Delayed sleep phase disorder Non-24-hour sleep-wake disorder Chronotherapy Sleep Sleep ...
Dang is also a proponent of chronotherapy, the idea that the delivery of drugs can be timed to take advantage of the body's ...
Possible treatments for circadian rhythm sleep disorders include: Chronotherapy, best shown to effectively treat delayed sleep ...
... chronotherapy (treatment scheduling) chrysotherapy climatotherapy cobalt therapy cold compression therapy combination therapy ...
The safety of chronotherapy is not fully known. While chronotherapy has been successful for some, it is necessary to rigidly ... In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person ... Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New ... A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ...
Notably, the application of chronotherapy, which is a systematic execution of strategies that curtail seizures occurring from ... Such measurements have immense value for developing patient-specific management of seizures using chronotherapy in the future. ... Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy, recently published in the journal ... Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy. Neurosci Biobehav Rev, 98:122-134 ...
Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: improved sleep-time blood pressure ... Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: improved sleep-time blood pressure ...
"Chronotherapy" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Chronotherapy" by people in this website by year, and whether ... Below are MeSH descriptors whose meaning is more general than "Chronotherapy".. *Analytical, Diagnostic and Therapeutic ... The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to ...
Chronotherapy refers to the use of circadian or other rhythmic cycles in the application of therapy. Examples of this are ... Chronotherapy (sleep phase). In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, ... The safety of chronotherapy is not fully known. While chronotherapy has been successful for some, it is necessary to rigidly ... Other forms of sleep phase chronotherapy:. A modified chronotherapy is called controlled sleep deprivation with phase advance, ...
Chronotherapy: Counting down cancer. Continuing with the personalization theme, Dr. Robert Dallmann from Warwick Medical School ... chronotherapy. :. "Propelled by the 2017 Nobel Prize in Medicine or Physiology [going] to three circadian biologists for ... uncovering the molecular mechanism of circadian biological clocks, cancer chronotherapy is gaining critical momentum to enter ...
A unique service of our program is outpatient triple chronotherapy that combines Wake therapy, sleep phase advance and bright ... Our chronotherapy program will provide circadian rhythm-based treatments for depression, seasonal affective disorder, and ... Triple Chronotherapy Process. These treatment process takes place over a three day period. During this time, all of your waking ... We use a combination of wake and bright light therapy along with sleep phase advance - termed triple chronotherapy - as our ...
Chronotherapy is basically therapy using manipulation of sleep, wake and light. There are different types of Chronotherapy:. * ... Tags: Circadian Rhythm treatment bipolar Chronotherapy Depression - TV Show Blog APA Reference. Tracy, N. (2010, November 18). ... How is Chronotherapy Thought to Work?. As with most complicated things in life, we arent quite sure. What we are pretty sure ... What Does Chronotherapy Mean?. Well, Im not sure, but if a drug-free treatment could produce results in three days I would ...
In the treatment of hypertension, investigation of chronobiology, chronopharmacology and chronotherapy began a few decades ago ... This article reviews the chronobiology of hypertension and the chronopharmacology and chronotherapy of the Diltiazem ... However, different medications have been studied for their chronopharmacology and potential chronotherapy. ... Chronotherapy of Cardiac Diseases using Diltiazem HCl - A Review Author(s): V. Kamalakkannan, K.S.G. Arul Kumaran, P. Meena ...
In this paper we explore a new implantable stimulator that implements chronotherapy as a feedforward input to supplement both ... The use of digitally-enabled chronotherapy as a feedforward signal to augment adaptive neurostimulators could prove a useful ... In this paper we explore a new implantable stimulator that implements chronotherapy as a feedforward input to supplement both ... The use of digitally-enabled chronotherapy as a feedforward signal to augment adaptive neurostimulators could prove a useful ...
... and their normalisation with methods of chronotherapy might become an important element of therapeutic treatment. Chronotherapy ... and their normalisation with methods of chronotherapy might become an important element of therapeutic treatment. Chronotherapy ... Sleep deprivation as a method of chronotherapy in the treatment of depression ...
Chronotherapy is a method of administration of drugs in specific combinations and at specific times, in order to achieve the ... Chronotherapy has also been shown to contribute to the regulation of arterial hypertension, especially during the night, and to ... Conclusions: Evidence from the treatment of both cancer and hypertension support the concept that chronotherapy has many ... The Role of Chronotherapy in the Management of Cancer and Arterial Hypertension ...
Chronotherapy. *Nutrition and mental health. *Single case experimental design methodology. Teaching. I teach on anxiety ...
Disturbances in circadian rhythm-the approximately 24-hour cycles that are endogenously generated by an organism-can be categorized into 2 main groups: transient disorders and chronic disorders. Transient disorders include jet lag or a changed sleep schedule due to work, social responsibilities, or illness.
Triple chronotherapy succeeds with home treatment for major depression. For Professionals. Realizing the Promise of ...
Two years ago, the Chronobiology and Chronotherapy Task Force of the International Society of Bipolar Disorders reviewed all ... Of all the conditions for which chronotherapy has been applied, bipolar disorders might be an especially rich intervention. ... the clinical studies done on each type of chronotherapy to determine its effectiveness and tolerability in the acute and ...
A Time to Heal: Chronotherapy Tunes In to Bodys Rhythms. February 23, 2001 ...
Chronotherapy in Congenital Adrenal Hyperplasia. Ross Richard A central tenet in medicine is that disruption of homeostatic ...
Chronotherapy: This therapy approach uses progressive advancement or delay (three hours every two days) of sleep time, ...
Circadian; alcohol use disorder (AUD); Zeitgeber; daily structure; addiction; chronotherapy; depression; personalized ...
Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy. Hill RJW, Innominato PF, Le´vi F, ... Updated Aug 22nd 2022: Chronotherapy Clinical Trial with a different Drug which is a good background resource. ... Core Concept: Emerging science of chronotherapy offers big opportunities to optimize drug delivery https://lnkd.in/gpAz-28v ...
Circadian rhythm in atopic dermatitis-Pathophysiology and implications for chronotherapy. Vaughn AR, Clark AK, Sivamani RK, Shi ...
... the National Institutes of Health for work on a personalized integrated chronotherapy for perinatal depression; March of Dimes ...
Executive One Person Infrared Salt Cave Sauna w/FREE 5G Harmonizer - Chronotherapy Low EMF ...
Bedtime hypertension treatment improves cardiovascular risk reduction the Hygia Chronotherapy Trial (2019) 1 de outubro de 2019 ... Bedtime hypertension chronotherapy, Cardiovascular risk, Coronary revascularization, Heart failure, Myocardial infarction, ...
Experimental chronotherapy of mouse mammary adenocarcinoma MA13/C with docetaxel and doxorubicin as single agents and in ...
Background: Degenerative spine disorders (DSD) are the most frequent reason of morbidity in adults. Commonly DSD includes degenerative disorders of intervertebral discs (IVDs), spinal stenosis and degenerative spondylolisthesis (SL). There is increasing evidence about significant role of cytokines in DSD pathogenesis, symptomathology and progression, but their protective levels remain still unknown.. Material and Methods: The aim of presented study was to provide quantitative and qualitative analysis of cytokine, chemokine and growth factors levels in individual parts of IVDs - annulus fibrosus (AF) and nucleus pulposus (NP) - separately and in facet joints (FJ) subchondral bone of patients with DSD and in controls - healthy subjects during a multiorgan procurement procedure. Bio-Plex® assay was used to measure concentrations of 27 different cytokines in tissue of patients with DSD. Their concentrations in tissues of healthy subjects during a multiorgan procurement procedure represented ...
  • The American Academy of Sleep Medicine has recommended chronotherapy for the treatment of circadian rhythm and sleep disorders. (wikipedia.org)
  • Circadian Rhythm and Chronotherapy - New Bipolar/Depression Therapy? (healthyplace.com)
  • The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. (numdam.org)
  • Morningness" or "eveningness" is thought to be highly influenced by genetics and is expressed as a preference rather than a modifiable behavior, even though behavioral measures combined with chronotherapy (light therapy, use of melatonin) can be used in people with misalignment of their biological clock and their environment in circadian rhythm sleep-wake disorders. (medscape.com)
  • Because circadian rhythms substantially shorter than 24 hours are extremely rare, this type of chronotherapy has remained largely experimental. (wikipedia.org)
  • Two years ago, the Chronobiology and Chronotherapy Task Force of the International Society of Bipolar Disorders reviewed all the clinical studies done on each type of chronotherapy to determine its effectiveness and tolerability in the acute and maintenance treatment of bipolar depression and mania. (cet.org)
  • In the treatment of hypertension, investigation of chronobiology, chronopharmacology and chronotherapy began a few decades ago. (rjptonline.org)
  • This article reviews the chronobiology of hypertension and the chronopharmacology and chronotherapy of the Diltiazem hydrochloride used in its management. (rjptonline.org)
  • Chronotherapy with valsartan/hydrochlorothiazide combination in essential hypertension: improved sleep-time blood pressure control with bedtime dosing. (druglib.com)
  • Chronotherapy is used in different fields, examples of this are the treatment of asthma, cancer, hypertension, and multiple types of depression, among others seasonal affective disorder and bipolar disorder. (findmeacure.com)
  • Chronotherapy has also been shown to contribute to the regulation of arterial hypertension, especially during the night, and to be a predictor for the appearance of cardiovascular complications. (hjn.gr)
  • Evidence from the treatment of both cancer and hypertension support the concept that chronotherapy has many advantages. (hjn.gr)
  • The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. (rtrn.net)
  • Disturbances of circadian rhythms play an important role in the pathogenesis of affective illnesses, and their normalisation with methods of chronotherapy might become an important element of therapeutic treatment. (psychiatriapolska.pl)
  • Chronotherapy is a method of administration of drugs in specific combinations and at specific times, in order to achieve the maximum therapeutic effect with the minimum side effects. (hjn.gr)
  • However, different medications have been studied for their chronopharmacology and potential chronotherapy. (rjptonline.org)
  • Chronotherapy uses the human phase response to light or melatonin. (wikipedia.org)
  • In cancer case studies better response was observed to chemotherapy administered according to chronotherapy principles, with a reduction of side effects and better quality of life. (hjn.gr)
  • In the 1990s, I came across a pioneer in the field, Dr. William Hrushevsky, who actually had the original idea of what today we call chronotherapy or chronomodulated chemotherapy, time sensitive drugs (chrono means time sensitive). (blockmd.com)
  • Hiroki Ueda, a researcher at the RIKEN Center for Developmental Biology in Kobe, Japan, says that some doctors are already using chronotherapy in treatments such as chemo for colon cancer. (discovermagazine.com)
  • There is a need for more randomized studies with larger samples of patients in order to document the possible advantages of chronotherapy for wider clinical practice. (hjn.gr)
  • This study may provide scientific evidence for the application of chronotherapy in clinical practice. (bvsalud.org)
  • We use a combination of wake and bright light therapy along with sleep phase advance - termed triple chronotherapy - as our standard protocol whenever wake therapy is prescribed. (chicagochronotherapy.org)
  • Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New England Journal of Medicine in 1992. (wikipedia.org)
  • Of all the conditions for which chronotherapy has been applied, bipolar disorders might be an especially rich intervention. (cet.org)
  • Chronotherapy refers to the use of circadian or other rhythmic cycles in the application of therapy. (findmeacure.com)
  • Chronotherapy is basically therapy using manipulation of sleep, wake and light. (healthyplace.com)
  • The use of digitally-enabled chronotherapy as a feedforward signal to augment adaptive neurostimulators could prove a useful algorithmic method in conditions where sensitivity to temporal patterns are characteristics of the disease state, providing a novel mechanism for tailoring a more patient-specific therapy approach. (ox.ac.uk)
  • We will review "chronotherapy," Social Rhythm therapy, and several PsychoEducation techniques that you can immediately apply with clients. (pesi.com)
  • A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. (wikipedia.org)
  • Sometimes, although extremely infrequently, "reverse" chronotherapy - i.e., gradual movements of bedtime and rising time earlier each day - has been used in treatment of patients with abnormally short circadian rhythms, in an attempt to move their bedtimes to later times of the day. (wikipedia.org)
  • Chronotherapy is a successful treatment of diseases may depend on the time of day or month that a medicine is taken or surgery performed. (findmeacure.com)
  • Here is an example of how chronotherapy could work over a week's course of treatment, with the patient going to sleep 3 hours later every day until the desired sleep and wake time is reached. (wikipedia.org)
  • Our staff includes psychiatric nurses and graduate students in clinical psychology who have received training in chronotherapy and biological rhythms. (chicagochronotherapy.org)
  • While chronotherapy has been successful for some, it is necessary to rigidly maintain the desired sleep/wake cycle thenceforth. (wikipedia.org)
  • Studies in animals suggest that a hypernyctohemeral syndrome could occur as a physiologic aftereffect of lengthening the sleep-wake cycle with chronotherapy. (wikipedia.org)
  • In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person is sleeping on a normal schedule. (wikipedia.org)
  • In this paper we explore a new implantable stimulator that implements chronotherapy as a feedforward input to supplement both open-loop and closed-loop methods. (ox.ac.uk)
  • Methods like this aren't exactly practical, which has been an obstacle to chronotherapy. (discovermagazine.com)
  • This approach, known as chronotherapy, is gaining attention as research suggests a relationship between when we take medications and how well they work. (harvard.edu)
  • Chronotherapy: Resetting the circadian clocks of patients with delayed sleep phase insomnia. (wikipedia.org)
  • It is used as a form of chronotherapy that can help to cure some sleep disorders . (fact-index.com)
  • Apart from the clinical applications, chronotherapy is becoming increasingly popular in non-clinical settings, for example on the work floor, where it is used to increase productivity and performance. (findmeacure.com)
  • How is Chronotherapy Thought to Work? (healthyplace.com)
  • Scientists can also carry out transgenic work and test timed dosing regimes (chronotherapy). (manchester.ac.uk)
  • This graph shows the total number of publications written about "Chronotherapy" by people in this website by year, and whether "Chronotherapy" was a major or minor topic of these publications. (rtrn.net)
  • Below are the most recent publications written about "Chronotherapy" by people in Profiles. (rtrn.net)
  • The idea of coordinating medical treatments with the ticking of patients' internal watch hands is called 'chronotherapy. (discovermagazine.com)
  • The idea of Chronotherapy then, is to reinstate a natural sleep rhythm. (healthyplace.com)
  • Chronotherapy is based on a controlled exposure to environmental stimuli which affect biorhythms. (psychiatriapolska.pl)