The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
The adaptation of drug administration to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
A progressive advance or delay of bedtime until the desired bedtime is achieved.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.
A multidisciplinary field of research and practice studying the periodicity of biological systems and the application of principles of chronobiology to various therapeutic strategies. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Excessive or inappropriate LACTATION in females or males, and not necessarily related to PREGNANCY. Galactorrhea can occur either unilaterally or bilaterally, and be profuse or sparse. Its most common cause is HYPERPROLACTINEMIA.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Discussions, descriptions or catalogs of public displays or items representative of a given subject.
Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available.
Transmission of live or pre-recorded audio or video content via connection or download from the INTERNET.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
Elements of limited time intervals, contributing to particular results or situations.
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (1/56)

AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin.  (+info)

Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration. (2/56)

Temporal variations in the renal toxicity of aminoglycosides have been reported for experimental animals as well as for humans. In fact, maximal renal toxicity of aminoglycosides was observed when the drug was given during the rest period, while a lower toxicity was observed when the drug was injected during the activity period. The aim of the present study was to evaluate temporal variations in the effectiveness and renal toxicity of gentamicin in an experimental model of pyelonephritis in rats. The experiments were carried out with female Sprague-Dawley rats (185 to 250 g). They had free access to food and water throughout the study and were maintained on a 14-h light-10-h dark cycle. Animals were divided into four groups corresponding to the respective time of induction of pyelonephritis and treatment: 0700, 1300, 1900, and 0100 h. Pyelonephritis was induced by a direct inoculation of Escherichia coli (10(7) to 10(8) CFU) in the left kidney. Animals were treated for 3 and 7 days with a single daily dose of gentamicin (20 and 40 mg/kg of body weight, respectively) or saline (NaCl, 0.9%) at either 0700, 1300, 1900, or 0100 h. Animals treated at 0100 h for 3 days with gentamicin (20 mg/kg) showed a significantly lower number of bacteria in their kidneys than did all other groups (P < 0.01). After 7 days of treatment, the efficacy, evaluated by the log CFU per gram of tissue and by the percentage of sterilized kidneys, was also higher when gentamicin was administered at 0100 h. The beta-galactosidase and the N-acetyl-beta-D-glucosaminidase activities were significantly higher in urine of rats given gentamicin at 1300 h than in urine of rats treated at another time of day (P < 0.05). Gentamicin injected at 1300 h induced a significantly greater increase of [3H]thymidine incorporation into DNA of renal cortex (P < 0.01), a significantly greater inhibition of sphingomyelinase activity (P < 0.05), and significantly more histopathological lesions than the same dose injected at another time of the day. Creatinine and blood urea nitrogen levels in serum were significantly higher (P < 0.05) and the creatinine clearance was significantly lower (P < 0.05) when gentamicin was injected at 1300 h than when it was injected at another time of day. Our data suggest temporal variations in both the toxicity and the effectiveness of gentamicin, the drug being more effective and less toxic when injected during the activity period of the animals.  (+info)

High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion. (3/56)

The purpose of the study was to examine inter- and intrapatient variation in 5-fluorouracil (5-FU) plasma concentrations in adult cancer patients receiving a 3-day drug infusion. Fourteen patients received 1266 mg/m2 N-(phosphonacetyl)-L-aspartate (PALA) infused i.v. over 15 min on day 1, followed immediately by a loading dose of 500 mg/m2 calcium leucovorin over 30 min. Then a prolonged infusion of leucovorin at 500 mg/m2/day and 5-FU at 1750 mg/m2/day was administered as either a constant rate or as a circadian infusion over 72 h. During constant rate infusions, 5-FU concentrations within individuals varied by 1.7-fold, but no uniform time of peak or trough concentration was observed. Transformation of these data by setting the time of peak to 0 h and by expressing concentrations as the percentage of the 24-h mean value revealed a nonrandom distribution of the time from peak to trough with a median time of 12 h (P = 0.027). These transformed data were also successfully fit to a circadian cosinor function (P < 0.001). During multiple constant rate 5-FU infusions, the intrapatient variability was high; the times of peak 5-FU concentration occurred at the same approximate sampling time 43% of the time, and troughs coincided 17% of the time. No difference in clinical toxicity was observed when matched constant rate and circadian infusions of 5-FU were compared. High inter- and intrapatient variability exists in 5-FU plasma concentrations in adult cancer patients during constant rate infusions with no evidence of a consistent circadian rhythm in untransformed data.  (+info)

Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. (4/56)

CONTEXT: Long-term survival of patients with metastatic colorectal cancer has been achieved only in patients who underwent complete resection of metastases. Such surgery could be performed in a greater proportion of patients if effective chemotherapy could downstage previously unresectable metastases. This approach has been limited by the low tumor response rate achieved with conventional chemotherapy. OBJECTIVE: We studied the outcome of patients with initially unresectable liver metastases from colorectal cancer treated with a three-drug chemotherapy regimen followed by liver metastases surgery whenever possible. PATIENTS AND METHODS: From March 1988 to June 1994, 151 patients with colorectal liver metastases were considered initially unresectable because of large tumor size (> 5 cm), multinodular (> 4) or ill-located metastases. All patients received fully ambulatory chemotherapy with 5-fluorouracil, leucovorin and oxaliplatin (chronotherapy in 83% of them). They were periodically reassessed for surgery by a joint medico-surgical team. RESULTS: In 151 patients, the size of liver metastases decreased by > 50% in 89 patients (59%) and median overall survival was 24 months (95% confidence interval (95% CI): 19-28 months), with 28% surviving at five years (20%-35%). Surgery with curative intent was attempted in 77 patients (51%), complete resection of liver metastases was achieved in 58 patients (38%). The median survival of the 77 operated patients was 48 months (25-71), with a five-year survival rate of 50% (38-61). CONCLUSION: This new strategy of combining effective chemotherapy with surgery apparently altered the natural history of unresectable colorectal cancer metastases.  (+info)

Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. (5/56)

PURPOSE: To study how adding oxaliplatin (l-OHP) to chronomodulated fluorouracil (5-FU)-leucovorin (LV) affected the objective response rate, as first-line treatment of metastatic colorectal cancer. PATIENTS AND METHODS: Two hundred patients from 15 institutions in four countries were randomly assigned to receive a 5-day course of chronomodulated 5-FU and LV (700 and 300 mg/m(2)/d, respectively; peak delivery rate at 0400 hours) with or without l-OHP on the first day of each course (125 mg/m(2), as a 6-hour infusion). Each course was repeated every 21 days. Response was assessed by extramural review of computed tomography scans. RESULTS: Grade 3 to 4 toxicity from 5-FU-LV occurred in +info)

Biological time and in vivo research: a field guide to pitfalls. (6/56)

Biological rhythmicity is a fundamental characteristic of all life forms, from primitive bacteria to man. The molecular biology, genetics, and the neurobiology of the biological clock(s) are being elucidated. Daily (circadian) statistically significant fluctuations occur in all of the normal biological variables studied in the experimental animal and the human. Many researchers, however, are not aware of the negative impact biological rhythmicity can have on experimental design and/or data interpretation. This article serves not as a review, but as a "field guide" to the pitfalls that can occur when research is performed in the absence of an understanding of biological rhythmicity. The major topics discussed are: 1) data transfer from the diurnally in-active/resting/sleeping lab animal to the diurnally active human, 2) frequency of sampling, 3) free-running vs. synchronization, 4) alternating periods of resistance and susceptibility, 5) phase shifting of a rhythm, 6) the assumption that one mean +/- S.E. from control animals can be "stretched" across an experimental time span, and 7) plotting data on an "hours after treatment" format vs. a "time of day" format. The hope is that by avoiding the pitfalls, biological time will become an ally in the endeavor to understand human biology.  (+info)

Chronotherapeutic delivery of verapamil in obese versus non-obese patients with essential hypertension. (7/56)

BACKGROUND: The effect of controlled-onset, extended-release (COER) verapamil on haemodynamic parameters in obese and non-obese patients is evaluated in this analysis. METHODS: Data were pooled from three clinical trials evaluating efficacy and tolerability of COER-verapamil. Hypertensive men and women (stage I to III) were randomised to COER-verapamil (180-540 mg at bedtime) or placebo for 4-8 weeks and stratified according to body mass index (BMI-obese > 28 kg/m2). Efficacy was assessed as change from baseline in blood pressure (BP), heart rate, and rate-pressure product during four time periods throughout the dosing interval. Safety and tolerability were assessed by monitoring all adverse events and changes in metabolic laboratory parameters. RESULTS: Reductions in all haemodynamic parameters were significantly greater following COER-verapamil compared with placebo for all time periods. The haemodynamic effects of COER-verapamil in obese (n = 166, BMI = 32.8 kg/m2) and non-obese patients (n = 115, BMI = 25.0 kg/m2) were similar. COER-verapamil was well tolerated in both subgroups, but the incidence of constipation was significantly less in obese patients (P < 0.001). CONCLUSIONS: COER-verapamil is effective in reducing BP, heart rate, and rate-pressure product independently of BMI.  (+info)

Weekly docetaxel in breast cancer: applying clinical data to patient therapy. (8/56)

The use of weekly 35-40 mg/m2 docetaxel, typically on a schedule of 6 weeks of therapy followed by a 2-week break, has produced response rates ranging from 33%-50% in patients with advanced breast cancer, the majority of whom have already received chemotherapy. These encouraging levels of response are seen across disease sites and in patients with prior anthracycline exposure. Importantly, the weekly administration of docetaxel allows prolonged treatment to a high cumulative dose: the weekly regimen is minimally myelotoxic, and neuropathy and other adverse events are infrequent. Weekly single-agent docetaxel may be a useful therapy in particular groups of patients such as those with reduced bone marrow reserve. It may also be a helpful means of delivering a highly active cytotoxic drug in combination with radiation therapy, other proven chemotherapy agents such as doxorubicin, and new, highly promising biological agents such as HERCEPTIN:  (+info)

Chronotherapy for rheumatoid arthritis: current perspectives Hideto To Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder of unknown etiology. Morning stiffness, a characteristic feature of RA, shows a 24-hour rhythm. Cytokines, which are considered to play an important role in the pathogenesis of RA, also exhibit a 24-hour rhythm, with a peak in the early morning. These rhythms have been attributed to the endogenous hormone balance and changes in expression levels of clock-related genes. Chronotherapy based on the 24-hour rhythm of RA has been performed using glucocorticoids and disease-modifying antirheumatic drugs. In a previous study, it was reported that modified-release prednisone tablets were administered to patients with RA at night, which demonstrated that the severity of morning stiffness was markedly less than that in patients receiving the
Title:Considering Circadian Pattern of Blood Pressure in the Treatment of Hypertension via Chronotherapy: A Conducive or Maladroit Approach. VOLUME: 20 ISSUE: 12. Author(s):Rina Das* and Dinesh Kumar Mehta. Affiliation:M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, HR, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, HR. Keywords:Chronotherapeutics, hypertension, biologic rhythms, antihypertensives, homeostasis, chronobiology.. Abstract:Medical chronobiology deals with the way bodys rhythm influences a persons health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeostasis has been the base for the treatment of diseases. Little importance has been given in understanding biologic rhythms and their underlying mechanisms. ...
Ask Dr. Dressler: Chronotherapy: Its all in the timing In this seminar, Dr. Dressler talks about the bodys circadian rhythms, and how the timing of your dogs different body processes can figure into cancer treatments. Some treatments are both safer and more effective at certain times of day - and less safe or even h
The advantages of the field of chronotherapy are endless. If we can properly time our use of drugs to follow the circadian rhythms of disease, we are able to increase the efficacy and effectiveness of common pharmaceuticals, while decreasing toxic side effects. For example, the knowledge that our blood pressure increases during wakefulness and decreases at sleep time is common. However, taking it one step further, we find that patients with chronically high blood pressure do not follow the same rhythm: it stays at a constant high throughout the day which weakens their heart and blood vessels and progresses to heart failure. The preferred treatment for these patients is ACE inhibitors which are a class of drugs that work to decrease blood pressure. Patients are usually instructed to use them during the day, however, a study by Martino et al. found that administering the ACE inhibitor, captopril, is significantly more effective at sleep-time than at wake-time in hypertensive models. It is thus ...
The molecular clock: a focus on chronopharmacological strategies for a possible control of aminoglycoside renal toxicity Marcela RebueltoFarmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, ArgentinaAbstract: Chronotherapy applies biological rhythmicity in order to optimize clinical treatments, relating the dosing time of the drugs to the daily variations of their therapeutic and unwanted side effects due to the fluctuations in physiological processes involved in their pharmacokinetics and/or pharmacodynamics. The goal of chronotherapy is to administer treatments at the time of day that enhances both their effectiveness and tolerance. This review intends to (1) provide the theoretical rationale behind the use of aminoglycosides during extended interval schedule chronotherapy in clinical practice and (2) target the underlying molecular mechanisms of renal toxicity, the main unwanted side effect. Previous reports suggest that aminoglycoside therapy may benefit
The combination of hepatic artery infusion (HAI) of irinotecan, 5-fluorouracil and oxaliplatin with intravenous cetuximab has safely achieved prolonged survival in colorectal cancer patients with extensive liver metastases and prior treatment. Systemic exposure to the drugs or their main metabolites was determined during the first course of chronomodulated triplet HAI in 11 patients and related to toxicities after one or three courses. Consistent trends were found between the area under the plasma concentration-time curve (AUC) values of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN38; a bioactive metabolite), total oxaliplatin and platinum ultrafiltrate (P-UF), on the one hand, and subsequent leukopenia severity, on the other hand. Moreover, the maximum plasma concentration (C max) and the AUC of P-UF significantly predicted grades of diarrhoea (p = 0.004 and 0.017, respectively) and anaemia (p = 0.001 and 0.008, respectively) after the first course. Systemic drug exposure helps explain both ...
A surgical procedure is disclosed for joining, e.g., by stapling or clipping, body tissue of a patient situated in an internal body cavity of the patient from within the body cavity through a small opening into the body cavity. For example, the surgical procedure may be employed to repair indirect inquinial or femoral hernias in a laparoscopic procedure. A small opening is made into the body cavity at a site on the patients body remote from the body tissue to be joined in the internal body cavity. The body cavity is insufflated. An elongate tissue-joining instrument is inserted into the body cavity through the small opening. The instrument is moved through the insufflated internal body cavity to position a distal end of the instrument close to and on an internal side of the body tissue to be joined in the body cavity. The pieces of body tissue are then joined by the instrument by manipulation of the instrument at a proximal end thereof.
Introduction Multiple prospective clinical trials document improved normalization of asleep blood pressure (BP) and 24 h BP patterning-increase in...
Understanding the Complex Dynamics of the Molecular Circadian Clock and Designing a Metric of Clock Disruption in Cancer.. Supervisors: Professor David Rand (Systems biology and Mathematics) and Professor Francis Levi (Warwick Medical School). My project aims to elucidate the complexities of normal periodic gene expression, in order design a diagnostic tool to measure clock dysfunction for use in personalised medicine strategies in cancer chronotherapy.. ...
News-Medical.net Chronopharmacology or chronotherapy deals with the effects of a drug when taken at specific time of the day. This variable response to medication is due to the 24 hour biological clock or circadian rhythm of the body say experts. A new study has revealed that taking high blood pressure or hypertension pills at bed time could provide better protection against heart attacks and strokes. The study titled,
Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness. Cell division in many tissues and organs within the human body is regulated on a daily basis by the clock, providing the theoretical basis for chronotherapy of cancer, and manipulation of internal circadian rhythms provides treatments for several kinds of ...
Adequate amounts of good-quality sleep are vital for optimal functioning. Children and adults with learning disabilities (LD) appear to be at increased risk of suffering from various forms of sleep disturbance, with implications for their daytime functioning, caregivers stress, and the professionals involved in their care. This chapter will discuss current understanding about the nature, prevalence, and etiology of sleep disturbance in individuals with LD and reflect on special considerations of assessment and treatment (including sleep hygiene, behavioral therapy, chronotherapy, light therapy, and melatonin) for this population. Limitations in current knowledge are highlighted along with future research priorities. ...
Cancer, Circadian Timing System, Patients, Therapeutic, Anorexia, Biorhythms, Colorectal Cancer, Cytokines, Fatigue, Rest, Treatments, Wrist, Administration, Apoptosis, Biology, Cell Cycle, Chronotherapy, DNA, DNA Repair, Down Regulation
Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy, nephropathy, and vomiting are dose-limiting factors. Previous studies reported that chronotherapy decreased CDDP-induced nephropathy and vomiting. In the present study, we investigated the influence of dosing times on CDDP-induced peripheral neuropathy in rats. CDDP (4 mg/kg) was administered intravenously at 5:00 or 17:00 every 7 days for 4 weeks to male Sprague-Dawley rats, and saline was given to the control group. To assess the dosing time dependency of peripheral neuropathy, von-Frey test and hot-plate test were performed. In order to estimate hypoalgesia, the hot-plate test was performed in rats administered CDDP weekly for 4 weeks. On day 28, the withdrawal latency to thermal stimulation was significantly prolonged in the 17:00-treated group than in the control and 5:00-treated groups. When the von-Frey test was performed to assess mechanical
By ralst Skin temperature 33 degrees. Internal body temperature 37 degrees. Heart rate 64 beats per minute. Cameron eased her way through the door and crossed the room toward the window, swaying her hips as she passed Sarah, relaxing on the sofa. She stretched, bending her body with catlike grace, and exposing golden curves to the gentle caress of the morning sunlight. Skin temperature 33.3 degrees. Internal body temperature 37.1 degrees. Heart rate 72 beats per minute. Hands reaching towards the sky, Cameron arched her neck, her eyes closing in an imitation of bliss. Sarah grunted and picked up a magazine from where John had left it crumpled on the arm of the chair. Cameron kicked her shoes to one side and stretched her legs out before her in a manner guaranteed to show off her calves to their best effect. Skin temperature 33.7 degrees. Internal body temperature 37.3 degrees. Heart rate 81 beats per minute. The sound of tearing paper cut through the silence and Sarah tossed the remnants of the ...
These essential oils are high quality, pure plant extracts. Available for purchase in 5ml or 1ml bottles, or added to unscented Body Time products.
We all have a natural internal clock: our circadian rhythm. It makes us feel tired when its time to sleep and wakes us up on a schedule. And it can be...
Your internal Body clock. Do you wake up the same time of day? This is what it means -. We all have an internal clock system that helps bodily functions. Below is a list of times and organs associated with your internal body clock. If you have woken up the same time each night, some of your energy may be blocked or misdirected.. 9-11pm - Endocrine system, hormones Rebalances & enzymes are replenished. If you have problems or trouble falling asleep at this time you may be in flight or fight. I love and admire and respect chines medicine and get regular acupuncture treatments for the last 20 years. I especially love how Chinese medicine integrates emotions in the physical body and the direct correlation between specific negative emotions and their impact on specific organs. Fear creates a release of adrenaline which triggers flight or fight, response which has physiological effect. These responses include heightened mental alertness, higher blood pressure, muscle tensing, lack of appetite, ...
Surgical devices and methods for their use in manipulating internal body objects are provided. The subject devices have proximal and distal ends separated by an elongate member. Located at the distal end is at least one articulated member, and usually two or more articulated members. A manual means for actuating the one or more distal articulated members is located at the proximal end of the device. The elongate member may be flexible or rigid. The subject devices find use in a variety of applications, and are particularly suited for use in applications in which it is desired to manipulate an internal body object from a location external to the body.
When homeostasis is interrupted, the body can correct or worsen the problem by internal and external influences. Examples of homeostasis in the human body 1- Internal body temperature . The internal body temperature of humans is a great example of homeostasis. When an individual is healthy, their body temperature is maintained at 37 °.. ...
When the body is overrun with toxins or a sluggish detoxification it leads to decreased cellular energy. That translates to lower overall energy levels. Energy is produced in the body by cellular compartments know as mitochondria. The production of energy in these mini-factories can be disrupted by virtually any toxin. What makes it even worse is as energy production within a cell falls it leads to that cell becoming even more vulnerable to suffering from impaired detoxification as well as cellular damage. The good news is that by going on a successful program that provides the right nutritional support, you can get rid of toxins, boost cellular energy production, and help cells function more efficiently. The net result of these changes is that you feel more alive with higher energy levels.. ...
A.P. Biology Summer AssignmentJordan SakniCoelomate versus Acoelomate Body PlanCoelomates are organisms that have an internal body cavity lined completely with mesoderm. Acoelomates, on the other hand, either lack an internal body cavity altogether or ...
NTP Experiment-Test: 05158-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:35:24 Facility: Battelle Northwest Chemical CAS #: 1313-27-5 Lock Date: 07/13/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05158-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MOLYBDENUM TRIOXIDE Date: 04/04/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:35:24 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 MG/M3 30 MG/M3 100 MG/M3 ...
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) O-CHLOROBENZALMALONONITRILE (CS-2) NTP Experiment-Test: 05096-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:37 Facility: Battelle Northwest Chemical CAS #: 2698-41-1 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:37 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/ M3 M3 ...
A deep and restful sleep is essential to both our physical and emotional well-being. Our circadian rhythm, or internal body clock, not only regulates our sleep patterns, but also influences our blood pressure, body temperature, appetite, and the release of essential hormones by our brain. Those that experience insomni
We are all familiar with the negative consequences of getting too little sleep, but they may be more serious than just feeling a bit groggy. A new study published in the journal Science Translational Medicine has shown that sleep restriction, along with a disruption of ones internal body clock, can raise the risk of obesity and type 2 diabetes [1]. This could explain the increased rates of these conditions in shift workers and others who work at night.. ...
A diastolic blood pressure number of 90 or higher is considered to be hypertension or high blood pressure.. Differential Pulse Wave Index (DPI): Represents the overall health of the cardiovascular system. DPI is the main indicator that represents the aging of arteries. =, - b + c + d / a. It means if the (-) value is lower, the vascular aging degree is going bad.. DPI: See Differential Pulse Wave Index. Eccentric Constriction (EC): Represents the contraction power of vessels from the left ventricle. EC analyzes the b/a value out of basic waves. If the cardiac output is higher, the vascular state is good and the result value should be bigger in (-) value.. EC: See Eccentric Constriction.. Endothelium: An epithelium of mesoblastic origin composed of a single layer of thin flattened cells that lines internal body cavities (as the serous cavities or the interior of the heart).. Femoral Artery: The chief artery of the thigh that is a continuation of the external iliac artery lying in the anterior ...
Stress-When the percieved demands of a situation are greater than the percieved abillity to cope.. The autonomic nervous system (ANS)- Immediate stressors activate the sympathetic branch of the ANS. The sympathetic nervous system (SNS) prepares the body for fight or flight, the rapid action necessary when ananimal is under threat, This is achieved by the release of nonandreanaline, which activates internal body organs associated with fight or flight.. Fight or Flight- A term meaning an animal is energised to either fight or run away in response to a sudden stressor.. SNS induced changes included an increase in heart rate and blood pressure, increased pupil size and metabollic changes, such as the mobilisation of fat and glucose in the bloodstream.. The adrenal medulla- A second part of this rescource to stress includes the andrenal glands, especially the andrenal mudella. Neurons of the SNS travel to the medulla, causing it to release andrenaline into the bloodstream. Once in the bloodstream, ...
A steerable endoscopic sheath has a proximal end, a distal end and a working channel lumen disposed therein. A plurality of solid state light emitting devices such as light emitting diodes are positioned near the distal end of the sheath and are selectively energized to illuminate internal body tissues. An imaging device such as a photo diode or CCD array creates an image from light reflected from the tissue. The distal tip of the endoscopic sheath is selectively moveable with a deflection device that is insertable into the sheath. The deflection device includes a tip deflection mechanism that allows a user to move the tip of the deflection device. With the deflection device inserted in the sheath, movement of the distal tip causes a corresponding movement in the distal tip of the sheath. The distal tip of the sheath has a shape retaining mechanism that allows it to retain the shape imparted by the deflection device once the deflection device is removed from the sheath.
We all know how important it is to drink water, for some of us it takes a little pushing to get the right daily intake. Whilst we are often tempted to brush off the effects of dehydration, it can lead to significant body changes both externally and visually as well as to our internal body functions. Some of the more latent impacts will happen over a period of time and therefore less noticeable. However long term, dehydration is very bad for your health and could become a trigger for, depression, diabetes, skin conditions and worse still other more toxic diseases. Whilst it may seem somewhat dramatic, dehydration is a very dangerous and life threatening condition. In time of sickness dehydration can literally lead to death so ensuring you are also hydrated is really important ...
An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.
The invention provides improved methods and devices for heating a thermally conductive fluid within an internal body organ to thermally ablate or necrose the body organ. In an exemplary embodiment, the invention provides a thermal ablation device having an elongate member with a proximal end and a distal end. A heating apparatus is provided near the distal end of the elongate member which is constructed to heat a thermally conductive fluid without substantial direct heating of the heating apparatus. A fluid circulator is provided near the heating apparatus which circulates the thermally conductive fluid past the heating apparatus.
The acid-base balance and the topic of nutrition are of fundamental importance. Through many years of personal experience, from friends and customers, we recommend supporting the cupping massage with alkaline baths and alkaline nutrition.. Bernadette Ensfellner is the founder of E&M Vital. Her book: Medicine of internal body cleansing. What can the gut have to do with the appearance of the face? With rashes? Inflammation?. The products from E&M Vital are of the best quality. To the E&M website. ...
MODEL RELEASED. CT scanning. Doctors examining the results of a computed tomography (CT) scan of a patients chest and head (seen on screen). The patient (upper right) has been passed through the hole in the scanner. CT scanning uses X-rays to produce cross-sectional images of the scanned area, compiled by computer. This allows doctors to view internal body structures and diagnose medical conditions. In this case, the larynx was being examined. Photographed at the Fondation Rothschild, Paris, France. - Stock Image C002/1287
According to Newtons third law, all forces come in pairs (*). They involve two objects and the force of the one on the other is equal and opposite to the force on the one. An external force is one that acts between an object inside the system and an object outside. An internal force is one that acts between two objects both of which are inside the system. F=ma only concerns itself with external forces acting on internal bodies m. An internal force cancels out since the two sides of the force pair are equal and opposite. You get to pick which objects are inside the system and which are outside when you analyze the problem ...
Albany, NY (PRWEB) February 19, 2014 -- Medical imaging equipments primarily find application in obtaining images of internal body organs, tissues by using
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With all living organisms composed of 60 to 90 percent water, all organisms require the substance as a basic building material as well as to regulate internal body temperature, transport nutrients...
It is not only your internal body that can benefit from taking minerals and vitamins. It influences how you appear, as well. The best vitamins to take for beautiful hair and healthy skin and nails are oil based D, vitamins and E, and water based vitamins, C and biotin. Taking a good vitamin formulated with these Learn More will help you look great ...
At UnitedHealthcare, we are committed to improving the health care system.The TLC TV network opens doors to extraordinary lives. At TLC.com,. Lifestyle.Fastin Hi Tech Internal Body Cleansing And Detox Healthy Organic Detox Teas Dr Oz 2 Weeks Detox Diet. It can be great to have a lifestyle of natural and raw food.Elite Test 360 Fat Burner - Beginning. it requires dedication and sticking on the diet along with other activities a. is also manage this is to live a healthy.. ...
A triploblastic organism which does not have an internal body cavity other than the gut. The area between the gut and the organisms outer body wall is ...
CAMBRIDGE, Mass. - October 21, 2020 - SynDevRx, Inc., a clinical-stage oncology company, announces the completion of a series of preclinical studies demonstrating that its anti-cancer drug candidate, SDX-7320, inhibits PI3K/Akt inhibitor-induced hyperglycemia and subsequent hyperinsulinemia in normal mice and inhibits tumor growth in multiple models of HR+ breast cancer. The companys ongoing research places them at the vanguard of metabo-oncology, an emerging field of cancer research that focuses on the role metabolic hormones play in the development and progression of many common cancers, as well as tumor resistance developed in response to certain treatment.. SDX-7320 inhibits MetAP2, a clinically validated target that plays a key role in tumor growth, metastasis, angiogenesis, and metabolic dysfunction. In a series of efficacy and safety studies in a variety of syngeneic cancer models (breast, melanoma), SDX-7320 displayed single agent anti-tumor activity while improving metabolic ...
A small percentage of people may initially experience minor digestive changes when taking PGX. Slowly work up to the full dose to give your body time to adjust. It is important to drink adequate amounts of water (8-16 oz. or 1-2 cups) after taking PGX. Consult your health professional before use if you are under 18 years of age or have any health concerns. If you are taking medication, take it one hour prior to two hours after taking PGX. As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you have a medical condition, or anticipate a surgery. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. ...
That way the body will have a chance to rejuvenate. Ostarine For Trt if you dont give your body time to rest and recover then you are likely to get injured. Use caution when it comes to how heavy you lift because certain exercises are not good for lifting heavy.. Ideally youll get to the gym more often in order to keep your investment from going to waste. If you dont follow through with your Ostarine For Trt workouts paying your fees upfront can end up wasting a lot of money so only use this tactic if youve tried everything else. Do not think of your workout sessions as hard and sweaty work. Using those terms can make you feel less motivated and excited about exercising. When you refer to working out try to reference the activity by what it actually is as in swimming or jogging. buy sarms vs prohormone Dont lift weights for more than an hour at a time.. There can be individual differences but the main rule is around there. It is the equivalent of ostarine 40 mg gtx-024 staying 15 minutes ...
Running has several profound effects on the body. Initially you may find it difficult as the body adapts to the changes in heart rate and ventilation rate caused by an increase in respiration in the active muscles. A moderate pace warm up can help give the body time to adjust to the changes. Over time the muscles will develop an increased capillary network and not only will the number of mitochondria (needed to supply energy to the body) increase so will their size. Over time the length of time you can run for will increase and providing you keep pushing your limits by a minute or two a week and you run three or four times a week your runs will get progresivly easier and mor enjoyable. Aim to do twentyy minutes three days a week (take a day off in between as this is when all the changes happen) if you have to run walk run walk to start off so be it but make sure you persist for twenty mins (its the length of time that builds up your stamina!). Happy running ...
There is no specific time that it is safe to begin trying again. Health care providers have many different points of view. Some recommend waiting at least 3 months after your loss to give your body time to heal. If your loss was during the first trimester this is usually a necessary wait from a physical point of view, however, it may make sense for some women to wait to allow the shock of the loss to wear off and to begin to assimilate their feelings before attempting a new pregnancy. In most cases, it is possible to get pregnant on your first cycle after your loss.You should discuss with your health care provider whether or not this is the right option in your specific case. If your doctor recommends waiting a period of time, ask them to explain why. ...
TY - JOUR. T1 - Chronotherapeutic drug delivery for early morning surge in blood pressure. T2 - A programmable delivery system. AU - Nayak, Usha Yogendra. AU - Shavi, Gopal Venktesh. AU - Nayak, Yogendra. AU - Averinen, Ranjith Kumar. AU - Mutalik, Srinivas. AU - Reddy, Sreenivasa Meka. AU - Gupta, Purshottam Das. AU - Udupa, Nayanabhirama. PY - 2009/6/5. Y1 - 2009/6/5. N2 - The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulations with constant/programmable delivery rates make it possible to deliver drug at definite time or controlled rate in chronopharmacokinetic studies. The prepared system contained swellable polymer (l-hydroxypropyl cellulose (L-HPC), xanthan gum, polyethylene oxide or sodium alginate) together with drug tablet and erodible tablet (L-HPC or guar gum) in a pre-coated capsule. Various ...
This invention relates to a pharmaceutical dosage form for the phase-controlled and chronotherapeutic delivery of at least one and, preferably, several pharmaceutically active ingredients. The dosage
ABSTRACT. Chronopharmaceutics is a branch of pharmaceutics devoted to the design and evaluation of drug delivery systems that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given disease therapy. A major objective of chronotherapy in the treatment of several diseases is to deliver the drug in higher concentrations during the time of greatest need according to the circadian onset of diseases or symptoms. The main objective of the present study is to develop single-unit pulsatile drug delivery system for obtaining no drug release till it reaches in colon followed by pulsed drug release in colon to achieve chronotherapeutic release of atenolol for treatment of hypertension and to improve the patient compliance. In vitro studies revealed that the tablet coated with guar gum and Eudragit S-100 have limited drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. Programmable pulsatile, ...
Recent advances in chronotherapeutics led to the development of pulsatile drug delivery systems which effectively delivered the drug at specified time. Diseases like asth..
Researchers from the University of Vigo, in Spain, found that people who took their blood pressure medication at bedtime had better-controlled blood pressure, giving them a 66 per cent lower risk of dying from heart and circulatory conditions. The risk of suffering a heart attack was reduced by 44 per cent, heart failure by 42 per cent, and stroke by 49 per cent.. Their analyses took into account factors that could affect the results, such as age, sex, type 2 diabetes, kidney disease, smoking and cholesterol levels.. These findings come from the Hygia Chronotherapy Trial, the largest study to date looking at the effect of the time people take their blood pressure medication on the risk of heart and circulatory diseases.. In the study, 19,084 people of Caucasian Spanish origin were randomly divided into two groups - half took their medication at bedtime and the other half took their medication just after waking up. The researchers then monitored their health for an average of six years, with a ...
Delayed Sleep Phase Syndrome Table of Contents Introduction 1 Causes 2 Symptoms 2 Testing 3 Sleep diary 3 Actigraphy 3 Treatment 3 Bright light therapy 3 Chronotherapy 4 Sleep hygiene 5 Melatonin 5 Vitamin
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The primary objective of the present study is to examine whether the combination of the antidepressant duloxetine and chronotherapeutic methods (including sleep deprivation, light therapy, and maintaining a regular sleep-wake rhythm) in patient with major depression, will induce an immediate improvement from depression and whether this antidepressive effect will be maintained in the long term (29 weeks). Patient will be randomised to the above mentioned treatment or to an active group receiving exercise ...
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Eileen presents Episode 12: Circadian Rhythms with Paul Jaminet posted at Phoenix Helix, saying, This episode of the Phoenix Helix podcast covers Circadian Rhythms: our internal body clock that does so much more than keep time. Balanced rhythms promote autoimmune healing, whereas wonky rhythms are a huge obstacle, throwing off our sleep, hormones, and so much more. Im joined by Dr. Paul Jaminet, author of The Perfect Health Diet, to teach us how to harness these rhythms for optimal health. We also talk about his dietary protocol in detail, why he recommends eating white rice, and how infections relate to autoimmunity. Its a great interview ...
Histamine is produced in the human body by some of the white blood cells called basophils, eosinophils, and by mast cells found especially numerous at sites of potential injury € the nose, mouth, and feet, internal body surfaces, and blood vessels. Its role is to increase the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. Histamine is known to be involved in many physiological functions because of its chemical properties that allow it to be versatile in binding. Ref. Histamine has multiple effects on both innate and adaptive immune responses, mediated by the four histamine receptors (H1€H4). In relation to cancer, histamine is associated with an immunosuppressive tumour microenvironment, including an increase in CD4+CD25+ regulatory T cell (Treg) activity, reduced antigen-presenting activity of dendritic cells (DC), reduced NK-cell activity and increased myeloid-derived suppressor cell (MDSC) activity ...
Methods used to produce pictures of internal body structures; for example, X-ray films, ultrasonography, computed tomography (CT) scans, and magnetic resonance imaging (MRI).. ...
A magnetic resonance imaging (MRI) is an imaging test that uses powerful magnetic forces and radio-frequency (RF) waves to make detailed 3-dimensional pictures of organs, soft tissues, bone and most other internal body structures. Some MRI scans require a contrast medium to provide clearer images.
A magnetic resonance imaging (MRI) is an imaging test that uses powerful magnetic forces and radio-frequency (RF) waves to make detailed 3-dimensional pictures of organs, soft tissues, bone and most other internal body structures. Some MRI scans require a contrast medium to provide clearer images.
Even today, biologists dont have a concrete definition of life. Usually, definitions of life are broken down into a set of descriptive criteria, most of which need to be met for something to be considered alive. Some of the most established criteria, as enumerated by Wikipedia, are as follows:. Homeostasis: self-regulation of the internal environment. Humans regulate our internal body temperature, and single-celled organisms can alter things such as chemical concentrations inside the cell.. Organization: being structured, generally, of one or more cells. This is a criterion bacteria would fail.. Metabolism: being able to transform chemicals or energy into cellular materials and being able to decompose organic matter. You eat food, organic matter, which you break down into energy for your body. Plants, via photosynthesis, convert the energy from light into food for themselves.. Growth: this one is fairly self-explanatory, though its helpful to note that a living thing increases in size in all ...
SECTION II - LINES WITH OTHER CLASSES AND WITHIN THIS CLASS. Class 604, Surgery, is an integral part of Class 128, Surgery, and all notes and class lines of Class 128 apply to Class 604. Class 604 follows the hierarchy of Class 128, Class 604 merely replaces the Medicators and Receptors portion of Class 128. For the purpose of convenience, Class 604 is referred to as a separate Class.. LINE WITH CLASS 4. Generic terms such as treatment, therapy, massage, hydrotherapy, hydromassage, etc., are to be interpreted broadly for placement in Class 4 lacking a disclosed body treatment for a named medical condition or physical injury. Exceptions to this rule comprise generically disclosed and claimed hydrotherapy of the genitalia or any internal body tissues, or a device for applying a force which imparts a specific motion to the body or portion thereof, or a device which is disclosed as providing treatment resulting in an internal action on the body which shall be classified in Class 128 or one ...
Dairy products are hard to digest and well-studied in its relationship to cancer and diseases. Fruit, vegetables, nuts, seeds, grains and plant-based protein, help extend longevity and promote beautiful skin to age slowly. Our skin is the largest organ on our body which reflects what the internal body cant get rid of - the skin will try to do so itself. This is especially true when it comes to the liver and digestive system. When you consume a lot or in some cases a little, dairy - the skin usually takes a major hit. This may be through acne, redness, blotchy or lackluster skin, Most people notice a big improvement in their skin when they ditch dairy. This is because our skin isnt left to do all the work itself to detox dairy. ...
With the help of different diagnostic imaging techniques in Grant LA 70644, the doctors may identify the cause of a disease or injury. These diagnostic machines in Grant LA 70644 are also helpful for doctors or physicians in ensuring if a diagnosis is appropriate or not. The diagnostic methods in Grant LA 70644 may comprise magnetic resource imaging (MRI), x-rays and Computed Tomography or CT scans.. The techniques help physicians in Grant LA 70644 see whats happening inside the body of the patients. The doctor becomes able to locate your bones, nerves, muscles and other organs on the x-ray image. These images let the health specialists identify any kind of internal body problem or abnormality.. X-rays or Radiographs. Radiograph is one among those techniques of imaging that are most prevalent in all the areas of the medical field. The part of the patients body that needs to be examined is placed between the machine and the photographic film. Electromagnetic waves pass through the body and the ...
A positive result was observed in an in vivo micronucleus assay in somatic cells exposed by the intraperitoneal route. In this case, there are additional data from in vivo tests with oral administration of the test substance showing negative results and the weight of evidence approach has been applied. Furthermore, data from an in vivo study on chromosomal aberrations in somatic cells by the oral route also showed negative results. It seems that genotoxicity can only be shown at internal body substance concentrations which cannot be achieved using application routes other than intraperitoneal. Furthermore, the intraperitoneal route of exposure is not relevant for human exposure. Hazard classification for germ cell mutagenicity primarily aims to identify substances causing heritable mutations or being suspected of causing heritable mutations. Therefore, this hazard class is primarily concerned with substances that may cause mutations in the germ cells of humans that can be transmitted to the ...
Magnetic Resonance Imaging is a diagnostic technique that produces computerized images of internal body tissue and is based on magnetic vibration of tiny molecules within the body induced by the application of radio waves. With no known side effects, MRI provides cross-sectional images of muscles, nerves, ligaments, tendons, spinal cord, brain, heart and breast
This is a state of internal body starvation that happens in the obese due to high amounts of insulin as a result of the very common insulin resistance that affects up to 71 percent of the population. In fact, misunderstanding of this internal starvation has lead to our popular culture of blame the victim attitude for obesity and weight gain. According to Dr. Prab R. Tumpati, MD, founder of W8MD medical weight loss centers of America, this state of starvation in the obese is what leads to food cravings, over eating, and weight gain that happens in the overweight or obese. ...
There are several types of weight loss supplements available in the market, which can be consumed in capsules or powder, such as weight loss shakes. The most sought after are thermogenic because they raise internal body temperature, accelerate metabolism and promote fat burning.. Some foods can be considered weight loss supplements. However, usually, a weight loss supplement is any pill, capsule, or tablet that includes herbal or chemical components explicitly formulated to increase your metabolism, which will allow your body to burn more calories. Aside from that, a weight loss supplement may also help you decrease your appetite so that you may take fewer calories.. Is not paired with a good exercise, weight loss supplements might have an inferior performance of weight loss supplements. Taking a pill should not stop there, you need to combine it with an efficient and enhanced exercise. You can search the Internet to find instructions for adequately using weight loss supplements for workouts, ...
With the help of different diagnostic imaging techniques in Garden City LA 70540, the doctors may identify the cause of a disease or injury. These diagnostic machines in Garden City LA 70540 are also helpful for doctors or physicians in ensuring if a diagnosis is appropriate or not. The diagnostic methods in Garden City LA 70540 may comprise magnetic resource imaging (MRI), x-rays and Computed Tomography or CT scans.. The techniques help physicians in Garden City LA 70540 see whats happening inside the body of the patients. The doctor becomes able to locate your bones, nerves, muscles and other organs on the x-ray image. These images let the health specialists identify any kind of internal body problem or abnormality.. X-rays or Radiographs. Radiograph is one among those techniques of imaging that are most prevalent in all the areas of the medical field. The part of the patients body that needs to be examined is placed between the machine and the photographic film. Electromagnetic waves pass ...
ISBN 978-0-470-97948-8. Dridi D, Zouiten A, Mansour HB (June 2013). "Depression: chronophysiology and chronotherapy". ...
Several other cases have been preceded by chronotherapy, a prescribed treatment for delayed sleep phase disorder. "Studies in ... Oren, Dan A.; Wehr, Thomas A. (December 10, 1992). "Hypernyctohemeral syndrome after chronotherapy for delayed sleep phase ... a hypernyctohemeral syndrome could occur as a physiologic aftereffect of lengthening the sleep-wake cycle with chronotherapy". ...
"Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy". International Journal of Molecular ...
Biological rhythm Chronotherapy (treatment scheduling) Circadian rhythm Clark Glymour, Douglas Stalker (1990). "Winning through ...
A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ... phase delay chronotherapy, is intended to reset the circadian clock by manipulating bedtimes. It consists of going to bed two ...
Terman M, McMahan I (2012) Chronotherapy: Resetting Your Inner Clock to Boost Mood, Alertness, and Quality Sleep. New York, ...
First Atlas of Body Clock Gene Expression in Mammals Informs Timing of Drug Delivery and Emerging Field of Chronotherapy: Penn ... Hogenesch's discovery that many proteins targeted by drugs experience circadian fluctuations made strides towards chronotherapy ...
Chronotherapy is sometimes used as a treatment, as an attempt to alter the phase of the individual's clock using cycles of ...
Once diagnosed, ASPD may be treated with bright light therapy in the evenings, or behaviorally with chronotherapy, in order to ...
A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ... A formerly popular treatment, phase delay chronotherapy, is intended to reset the circadian clock by manipulating bedtimes. It ...
Chronotherapy has also been prescribed for circadian rhythm disorders, though results are generally short-lived. Stimulants may ...
Possible treatments for circadian rhythm sleep disorders include: Chronotherapy, best shown to effectively treat delayed sleep ...
... chronotherapy (treatment scheduling) chrysotherapy climatotherapy cobalt therapy cold compression therapy combination therapy ...
The safety of chronotherapy is not fully known. While chronotherapy has been successful for some, it is necessary to rigidly ... In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person ... Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New ... A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ...
Chronotherapy, also called chronotherapeutics or chronotherapeutic drug delivery, refers to the use of circadian or other ... In the treatment of psychiatric conditions including bipolar depression, a form of chronotherapy combining intermittent sleep ...
The safety of chronotherapy is not fully known. While chronotherapy has been successful for some, it is necessary to rigidly ... In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person ... Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New ... A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. One stays awake one whole night and ...
Chronotherapy, also called chronotherapeutics or chronotherapeutic drug delivery, refers to the use of circadian or other ... In the treatment of psychiatric conditions including bipolar depression, a form of chronotherapy combining intermittent sleep ...
Doctors are becoming increasingly interested in the science of chronotherapy - aligning medical treatment to our circadian ... Media captionChronotherapy is about matching treatment around our Body Clock. Being in tune with your natural Body Clock is ... "We have found chronotherapy is reducing the toxicity of treatments and improving the quality of life of patients, by respecting ... He plans to continue his research into cancer chronotherapy and will treat patients at University Hospital Birmingham. ...
Chronotherapy based on the 24-hour rhythm of RA has been performed using glucocorticoids and disease-modifying antirheumatic ... Chronotherapy for rheumatoid arthritis: current perspectives Hideto To Department of Medical Pharmaceutics, Graduate School of ... Chronotherapy based on the 24-hour rhythm of RA has been performed using glucocorticoids and disease-modifying antirheumatic ...
What is chronotherapy?. Chronotherapy is a behavioral technique that typically seeks to "correct" a dysfunctional circadian ... chronotherapy, circadian rhythm, goodcancer, goodhealth, goodmedicine, goodscience, natural cures, natural medicine, research, ... In chronotherapy, bedtime is delayed by three-hour increments every day to create a 27-hour day. The method is repeated each ... This is why chronotherapy ought to be utilized as a natural and non-invasive treatment for cancer patients, according to Breus. ...
Recent advances in chronotherapy for the management of asthma Hannah J Durrington,1 Stuart N Farrow,2,3 David W Ray2 1Institute ...
Chronotherapy, involves timing delivery of drugs to minimize side effects while maximizing effectiveness. Heres how it can ... Chronotherapy Could Make Cancer Treatments More Effective, Heres How. Chronotherapy, involves timing delivery of drugs to ... "We still need to identify better biomarkers to personalize chronotherapy," says Francis Lévi, a chronotherapy researcher at the ... Most chronotherapy strategies are based on a limited understanding of clock biology -- which frustrates Dang, who has yet to ...
Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy (MAPEC). The ... Procedure: Chronotherapy, timing of antihypertensive medication Comparison of effects of awakening versus bedtime dosing ... Procedure: Chronotherapy, timing of antihypertensive medication Comparison of effects of awakening versus bedtime dosing ... Device: Ambulatory blood pressure monitoring Procedure: Chronotherapy, timing of antihypertensive medication Drug: ACEI ( ...
Chronotherapy for hypertension in obstructive sleep apnoea (CHOSA): a randomised, double-blind, placebo-controlled crossover ... Chronotherapy for hypertension in obstructive sleep apnoea (CHOSA): a randomised, double-blind, placebo-controlled crossover ...
Chronotherapy did not result in changes in any other sleep-wake parameter. Chronotherapy seemed to help adjusting to local time ... Keywords: chronobiology, sleep timing, temperature, chronotherapy, students, teaching How to Cite: Montagnese, S., Zarantonello ... The effect of chronotherapy in the student who had just come back from Asia was striking, confirming that jet-lag remains an ... CHRONOTHERAPY TRIAL. While continuing to fill in their sleep-wake diaries, 8 students (5 males; 23.6 ± 1.6 years of age; 1 ...
This new more physiological chronotherapy has excellent potential to significantly improve cortisol replacement in all types of ...
Chronotherapy with spirapril in hypertensive patients: changes in the diurnal/nocturnal blood pressure ratio as a function of ... Almirall J, Comas L, Martínez-Ocaña JC, Roca S, Arnau A. Effects of chronotherapy on blood pressure control in non-dipper ... Chronotherapy with torasemide in hypertensive patients: increased efficacy and therapeutic coverage with bedtime as compared to ... Chronotherapy with the angiotensin-converting enzyme inhibitor ramipril in essential hypertension: improved blood pressure ...
The advantages of the field of chronotherapy are endless. If we can properly time our use of drugs to follow the circadian ... HOMETHERAPEUTIC APPLICATIONSINTENSIVE CARE UNITSCHRONOTHERAPYBLUE LIGHT THERAPYDISEASE APPLICATIONSCARDIOVASCULAR DISEASE ... Clinicians and research should collaborate to further the field of chronotherapy and create more effective therapeutic ...
"Chronotherapy" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Chronotherapy" by people in this website by year, and whether ... Below are MeSH descriptors whose meaning is more general than "Chronotherapy".. *Analytical, Diagnostic and Therapeutic ... The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to ...
TAF Chronotherapy : New Hope for Cancer Patients Even with the ever-advancing medical technology, cancer still causes fever ... Hiroyuki Abe explained, TAF Chronotherapy with the traditional therapy of different cancer treatment method, it is possible ...
Chronotherapy can even be effective in disorders that show seasonal variation rather than a 24-hour circadian rhythm. Peptic ... Cancer Treatment and Chronotherapy. Chemotherapy is one of the cancer treatments where chronobiology is becoming increasingly ... Chronotherapy is common sense help for people suffering from diseases that also show patterns of exacerbation and remission. ... Patients do not have to have a serious illness such as cancer in order to benefit from chronotherapy. Allergic rhinitis is the ...
This chronotherapy could be used to reduce off-target as well as adverse effects while increasing on-target efficacy. This ...
International Journal of Pharmacy and Pharmaceutical Research (IJPPR) will give best paper award every year in the form of money along with certificate to support research activity of scholar ...
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Chronotherapy. Chronotherapy means rescheduling or shifting sleep/wake patterns in the hope that out-of-sync rhythms could be ...
See also: chronotherapy. chronotherapeutics. (krŏn′ō-thĕr′ə-pyo͞o′tĭks, krō′nə-). n. (used with sing. verb). 1. Medical ... chronotherapy. Any therapy based on the timing of physiologic and pathologic events.. Alternative medicine. The process in ... Chronotherapy establishes routines of exercise, eating, work, study, rest and sleep.. Oncology. The adminstration of ... Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side ...
Chronotherapy Group of European Organization for Research and Treatment of Cancer, Les Cliniques Saint Joseph, Liège, 4000, ... Granda TG, Filipski E, DAttino RM, Vrignaud P, Anjo A, Bissery MC, Lévi F (2001) Experimental chronotherapy of mouse mammary ... Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy *Narin Ozturk ... Lévi F, Zidani R, Misset JL (1997) Randomized multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic ...
Providing a Basis for Chronotherapy in Cancer. Speaker. Amita Sehgal, PhD. Perelman School of Medicine, University of ...
Dressler: Chronotherapy: Its all in the timing In this seminar, Dr. Dressler talks about the bodys circadian rhythms, and how ... Chronotherapy: Timing Your Dogs Cancer Medication [MP3]. Sale Price: $7.00 List Price: $27.00 ... Dressler: Chronotherapy: Its all in the timing. In this seminar, Dr. Dressler talks about the bodys circadian rhythms, and ... Learn more about the power of circadian rhythms and chronotherapy (time therapy) by listening to Dr. Dresslers webinar. ...
Sleep Phase Chronotherapy, Chronotherapies, Sleep Phase, Chronotherapy, Sleep Phase, Sleep Phase Chronotherapies. ... Ontology: Sleep Phase Chronotherapy. (C2350587) Definition (MSH) A progressive advance or delay of bedtime until the desired ... Sleep Phase Chronotherapy Czech. posun spánkové fáze - chronoterapie, nástup spánku - chronoterapie, čas spánku - chronoterapie ... Aka: Sleep Restriction Therapy, Cognitive Behavioral Therapy for Insomnia, CBT-I, Sleep Phase Chronotherapy, Temporal Control ...
Applications for chronotherapy. Together they form a unique fingerprint. * Chronotherapy Medicine & Life Sciences ... keywords = "Aging, Arctic, Blood pressure, Chronotherapy, Circadian rhythms, Heart rate, Hypertension, Melatonin, Variability", ... T2 - Mechanisms linking aging, disease state and Arctic shift-work: Applications for chronotherapy ... Applications for chronotherapy. / Gubin, D. G.; Cornelissen, G.; Weinert, D.; Vetoshkin, A. S.; Gapon, L. I.; Shurkevich, N. P ...
Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial December 7, 2019 General ...
Chronotherapy Market: Key Players: Examples of some of the key players identified in the global Chronotherapy Market are UCB ... Chronotherapy: Drivers and Restraints: Chronotherapy is increasing as it reduces the frequency of dosage. Also with the ... Chronotherapy Market: Segmentation: Tentatively, the global Chronotherapy market can be segmented on the basis of treatment ... The success of the chronotherapy depends on the time at which the medicine is administered by the patient. The Chronotherapy is ...
I have been wondering for quite some time about how circadian cycles could be added into the metabolic perspective. Normal cells behave in a highly re...
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.. Ye Y1, Xiang Y1, Ozguc FM1, Kim ... Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to ... The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy ... The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy ...
  • Moreover, with chronotherapy diseases such as hypertension, asthma, the drugs target specific sites which reduce the treatment time. (consultingindustry24.com)
  • Administration-time-dependent effects of blood pressure-lowering medications: basis for the chronotherapy of hypertension. (eu-jr.eu)
  • Chronotherapy of hypertension: Administration-time-dependent effects of treatment on the circadian pattern of blood pressure. (eu-jr.eu)
  • Chronotherapy With Valsartan/Hydrochlorothiazide Combination in Essential Hypertension: Improved Sleep-Time Blood Pressure Control With Bedtime Dosing. (eu-jr.eu)
  • The chronotherapy of hypertension is a relatively new practice in the UK. (bjgp.org)
  • 2011 ) Chronotherapy in hypertension: a pill at night makes things right? (bjgp.org)
  • With regards to cancer treatment, several studies have examined the effects of chronotherapy when combined with harmful cancer treatments like chemotherapy, radiation and synthetic medication. (naturalnews.com)
  • Chronotherapy may increase allowable doses of chemotherapeutics, while decreasing tumour burden and chemotherapy-related side effects. (thefreedictionary.com)
  • These findings led to the idea of chronotherapy, wherein medication or other treatment can be optimized by delivery at appropriate times of the day. (pnas.org)
  • Thus far, more than 15 different anticancer drugs have been reported to exhibit strong time-of-administration effects on their efficacy ( 15-17 ), leading to the innovative idea of chronotherapy. (aacrjournals.org)
  • The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy. (cdc.gov)
  • Minimising circadian disruption through the personalisation of chronotherapy delivery could help to improve clinical tolerability and potentially contribute towards the treatment being more effective," concludes Ortiz. (eurekalert.org)
  • to study the clinical effectiveness of chronotherapy for alopecia areata treatment. (eu-jr.eu)
  • image: Shown are the MRI scans of the brain of a participant in a clinical trial evaluating chronotherapy -- or the timed delivery of drugs, based on circadian rhythms -- for glioblastoma. (eurekalert.org)
  • Metastatic Colorectal Carcinoma The clinical relevance of the chronotherapy principle was tested in a large population of patients with metastatic colorectal carcinoma using the standard methodology of clinical trials. (zanran.com)
  • Accordingly, chronotherapy based on circadian phenotypes might be applied to improve therapeutic efficacy. (aacrjournals.org)
  • In chronotherapy, an attempt is made to move bedtime and rising time later and later each day, around the clock, until a person is sleeping on a normal schedule. (wikipedia.org)
  • Sometimes, although extremely infrequently, "reverse" chronotherapy - i.e., gradual movements of bedtime and rising time earlier each day - has been used in treatment of patients with abnormally short circadian rhythms, in an attempt to move their bedtimes to later times of the day. (wikipedia.org)
  • In chronotherapy, bedtime is delayed by three-hour increments every day to create a 27-hour day. (naturalnews.com)
  • Chronotherapy: Resetting the circadian clocks of patients with delayed sleep phase insomnia. (wikipedia.org)
  • We have found chronotherapy is reducing the toxicity of treatments and improving the quality of life of patients, by respecting the circadian rhythms of the patients. (bbc.com)
  • He plans to continue his research into cancer chronotherapy and will treat patients at University Hospital Birmingham. (bbc.com)
  • Cancer and circadian rhythm: Can chronotherapy benefit patients with cancer? (naturalnews.com)
  • This is why chronotherapy ought to be utilized as a natural and non-invasive treatment for cancer patients, according to Breus. (naturalnews.com)
  • But even in its current form, chronotherapy can provide cancer patients a way to inhibit the spread of cancer cells and suppress tumor growth without the harmful side effects linked to conventional cancer treatments. (naturalnews.com)
  • Dr. Hiroyuki Abe explained, TAF Chronotherapy with the traditional therapy of different cancer treatment method, it is possible without affecting normal cells to help patients control the rate of diffusion of cancer cells, as well as reduction of tumor volume, and finally make the natural apoptosis of cancer cells. (bestrade.biz)
  • Cancer, arthritis, allergic rhinitis and peptic ulcers are all examples of health problems where chronotherapy can be used to improve outcomes and deliver a higher quality of care to patients. (chronobiology.com)
  • Patients do not have to have a serious illness such as cancer in order to benefit from chronotherapy. (chronobiology.com)
  • Also, the increase in the healthcare expenditure and development of new drugs with better outcomes for the patients are driving the Chronotherapy market . (consultingindustry24.com)
  • Researchers characterised the evolution of the circadian system in cancer patients submitted to a standard chronotherapy protocol (synchronisation of medication with natural rhythms). (eurekalert.org)
  • The offered chronotherapy method has the expressed anabolic effect on patients' organism. (eu-jr.eu)
  • We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS, and thus, chronotherapy may be used to effectively manage ARDS in COVID-19 patients . (bvsalud.org)
  • I often recommend chronotherapy to patients. (athealth.com)
  • He said that chronotherapy is also being tested in patients with pancreatic, biliary, breast, and lung cancers. (cancernetwork.com)
  • Patients on chronotherapy tolerated the three-drug treatment better than the constant-rate patients did. (cancernetwork.com)
  • Dr. Lévi told ONI that this result showed that the chronotherapy was more active, with nearly twice as many patients in the chronotherapy arm rendered disease free. (cancernetwork.com)
  • Chronotherapy, also called chronotherapeutics or chronotherapeutic drug delivery, refers to the use of circadian or other rhythmic cycles of a condition's symptoms and/or of the individual being treated in the application of therapy. (wikipedia.org)
  • Learn more about the power of circadian rhythms and chronotherapy (time therapy) by listening to Dr. Dressler's webinar. (dogcancerblog.com)
  • and, second, whether potential changes in the circadian BP pattern after Chronotherapy with antihypertensive drugs are associated to changes in cardiovascular risk. (clinicaltrials.gov)
  • Chronotherapy uses the human phase response to light or melatonin. (wikipedia.org)
  • What is Chronotherapy and Chronos toxicity and how it effects cancer treatment. (dogcancerblog.com)
  • Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to lower toxicity. (cdc.gov)
  • Chronotherapy subjects had only one fifth as much severe mucosal toxicity and half as much peripheral sensory neuropathy, with both differences being statistically significant. (cancernetwork.com)
  • Because circadian rhythms substantially shorter than 24 hours are extremely rare, this type of chronotherapy has remained largely experimental. (wikipedia.org)
  • Doctors are becoming increasingly interested in the science of chronotherapy - aligning medical treatment to our circadian rhythms. (bbc.com)
  • The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. (sickkids.ca)
  • Circadian rhythms are already being taken into account in other countries, including England, France and Australia, in a practice called " chronotherapy . (dogcancerblog.com)
  • Chronotherapy refers to therapeutics which match the rhythms of the disorder and help in optimizing outcomes with minimum side effects. (consultingindustry24.com)
  • Chronotherapy is the practice of giving medications in synchrony with these rhythms. (mit.edu)
  • Thoracic surface temperature rhythms as circadian biomarkers for cancer chronotherapy. (nih.gov)
  • 1992) Rhythms in bone marrow cell proliferation: How to apply to the chronotherapy of cancer - Reply. (ntnu.no)
  • The American Academy of Sleep Medicine has recommended chronotherapy for the treatment of circadian rhythm and sleep disorders. (wikipedia.org)
  • Here is an example of how chronotherapy could work over a week's course of treatment, with the patient going to sleep 1 hour later every day until the desired sleep and wake time is reached. (wikipedia.org)
  • In the treatment of psychiatric conditions including bipolar depression, a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies. (wikipedia.org)
  • He treatment is being led by Professor Francis Levi, one of the pioneers of chronotherapy. (bbc.com)
  • According to a recent article published in Psychology Today , a leading magazine on behavioral science, chronotherapy may be used as a natural and non-invasive treatment for cancer . (naturalnews.com)
  • Although it has been introduced in the 1970s, chronotherapy remains a relatively new method of treatment, especially for chronic diseases like cancer . (naturalnews.com)
  • Chronotherapy remains a fairly recent method of treatment for cancer that is yet to be fine-tuned by sleep specialists and healthcare professionals. (naturalnews.com)
  • Chronotherapy is the treatment method in which availability of drugs tunes to the body clock. (consultingindustry24.com)
  • Also after the treatment, chronotherapy develops a non-24-h sleep-wake syndrome as the person sleeps for over 24 h. (consultingindustry24.com)
  • Chronotherapy Market: Segmentation: Tentatively, the global Chronotherapy market can be segmented on the basis of treatment type, indications, distribution channel and geography. (consultingindustry24.com)
  • At the study the high chronotherapy effectiveness at treating alopecia areata was revealed and the possibility of its use for the effective treatment of a series of other pathologies was proved. (eu-jr.eu)
  • The treatment options discussed are focused on improvement of sleep quality, quantity, and phase-resetting, by means of improving sleep hygiene, chronotherapy, treatment of specific sleep disorders, and by strengthening certain neuronal networks involved in sleep, e.g. by sensorimotor rhythm neurofeedback. (brainclinics.com)
  • Here again, the chronotherapy group did significantly better than the flat-infusion group, with a median time to treatment failure of 6.5 months vs 5.0 months. (cancernetwork.com)
  • Cancer and rheumatoid arthritis are two disease areas where chronotherapy is showing promise. (bbc.com)
  • The University of Manchester is conducting a small chronotherapy trial for rheumatoid arthritis. (bbc.com)
  • The MAPEC study was designed to investigate whether normalizing the circadian blood pressure profile towards a more dipper pattern (increasing the diurnal/nocturnal ratio of blood pressure) by the use of Chronotherapy (that is, taking into account the time of day of administration of antihypertensive medications) reduces cardiovascular risk. (clinicaltrials.gov)
  • Chronotherapy takes into account how circadian rhythm and other internal clocks affect treatments, especially medications. (chronobiology.com)
  • Chronotherapy based on the 24-hour rhythm of RA has been performed using glucocorticoids and disease-modifying antirheumatic drugs. (dovepress.com)
  • Chronotherapy is a behavioral technique that typically seeks to "correct" a dysfunctional circadian rhythm. (naturalnews.com)
  • Chronotherapy can even be effective in disorders that show seasonal variation rather than a 24-hour circadian rhythm. (chronobiology.com)
  • We investigated the relationship between the circadian rhythm in the tolerability and the anticancer efficacy of gemcitabine in mice, as a prerequisite for the development of chronotherapy schedules with this drug in human cancer. (nature.com)
  • Finally, during chronotherapy they took significantly less time to fall asleep. (jcircadianrhythms.com)
  • Fifty-one percent of the chronotherapy group achieved an objective response, significantly better than the 30% response rate of the flat-infusion group. (cancernetwork.com)
  • For a secondary endpoint, median progression-free survival, the chronotherapy group again did better, although not significantly so (9.3 months vs 7.2 months). (cancernetwork.com)
  • A modified chronotherapy is called controlled sleep deprivation with phase advance, SDPA. (wikipedia.org)
  • Prognostic Value of Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy in Relation to Risk (the MAPEC Study). (clinicaltrials.gov)
  • The Chronotherapy is expected to be promising in future in diseases such as asthma, cardiovascular diseases, and deficit syndromes in children. (consultingindustry24.com)
  • Chronotherapy has been known to cause non-24-hour sleep-wake disorder in at least three recorded cases, as reported in the New England Journal of Medicine in 1992. (wikipedia.org)
  • A phase III trial is now investigating whether chronotherapy improves survival as well as response rate. (cancernetwork.com)
  • Chronotherapy is common sense help for people suffering from diseases that also show patterns of exacerbation and remission. (chronobiology.com)
  • Short-term effects of green tea chronotherapy on the metabolic homeostasis of mice on different diets. (geneticsmr.com)
  • Chronotherapy, involves timing delivery of drugs to minimize side effects while maximizing effectiveness. (ndtv.com)
  • A literature review and relevance to the chronotherapy of cancer. (ntnu.no)
  • Studies in animals suggest that a hypernyctohemeral syndrome could occur as a physiologic aftereffect of lengthening the sleep-wake cycle with chronotherapy. (wikipedia.org)
  • The success of the chronotherapy depends on the time at which the medicine is administered by the patient. (consultingindustry24.com)
  • The acquisition of current data in circadian clock mechanism may help chronotherapy, which takes into consideration the biological time to improve treatments by devising new therapeutic approaches for treating circadian-related disorders, especially cancer. (jcircadianrhythms.com)
  • Chronotherapy is an emerging field in biomedicine that leverages on fine-tuning the timing of drug delivery to obtain a therapeutic effect. (clinicaltrials.gov)
  • Three drug chronotherapy against colorectal cancer. (zanran.com)
  • This chronotherapy could be used to reduce off-target as well as adverse effects while increasing on-target efficacy. (technologypublisher.com)
  • Efficacy was also better in the chronotherapy group. (cancernetwork.com)
  • The manufacturers are reviewing and making efforts by increasing the efficiency of drugs with Chronotherapy which is expected to increase the market. (consultingindustry24.com)
  • Introduction Roux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes are induced by calorie restriction, the weight loss or surgery per se, remains uncertain. (bmj.com)
  • The Chronotherapy Market offers great potential and holds a strong approach in future with its continued investment. (consultingindustry24.com)
  • Dr. Tamimi and his team have successfully harnessed chronotherapy using NSAIDs to enhance bone healing in a murine fracture model. (clinicaltrials.gov)
  • Plus, unlike conventional cancer treatments, chronotherapy allows the body to recover at its own pace without the added weight of harmful side effects like cognitive dysfunction and heart problems. (naturalnews.com)
  • Also with the adoption of chronotherapy, various side effects are avoided. (consultingindustry24.com)
  • In conclusion, significant abnormalities in the sleep-wake patterns of a small group of university students were observed, and the students seemed to benefit from chronotherapy. (jcircadianrhythms.com)
  • Chronotherapy Market: Key Players: Examples of some of the key players identified in the global Chronotherapy Market are UCB Pharma GmbH, GenPharma International Pvt. (consultingindustry24.com)
  • Introducing Chronotherapy Did you know the art and science of Chronotherapy has been adopted into our society? (cpapclinic.ca)
  • While chronotherapy has been successful for some, it is necessary to rigidly maintain the desired sleep/wake cycle thenceforth. (wikipedia.org)
  • The method of chronotherapy that gains an essential circulation in Ukraine and throughout the world may play the important role in its solution. (eu-jr.eu)
  • The main group included 45 persons - treated using the method of chronotherapy. (eu-jr.eu)
  • Chronotherapy for cancer is one of the hottest areas of study in oncology. (chronobiology.com)
  • Chronotherapy is the study and application of the sleep and wake cycles of the human being to optimize energy patterns. (cpapclinic.ca)
  • Overall, our results identified Bmal1 as a novel tumor suppressor gene that elevates the sensitivity of cancer cells to paclitaxel, with potential implications as a chronotherapy timing biomarker in TSCC. (aacrjournals.org)