Chronobiology Phenomena: Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.Chronobiology Discipline: A multidisciplinary field of research and practice studying the periodicity of biological systems and the application of principles of chronobiology to various therapeutic strategies. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.Chronotherapy: The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Chronobiology Disorders: Disruptions of the rhythmic cycle of bodily functions or activities.Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksChild Development: The continuous sequential physiological and psychological maturing of an individual from birth up to but not including ADOLESCENCE.Insects: The class Insecta, in the phylum ARTHROPODA, whose members are characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth; several hundred thousand different kinds having been described. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1)CLOCK Proteins: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.Book SelectionCircadian Clocks: Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.Textbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Physiology: The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Digestive System: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).Autonomic Nervous System: The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.Blood Volume: Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.ARNTL Transcription Factors: Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.Legislation, Veterinary: Laws and regulations, pertaining to the field of veterinary medicine, proposed for enactment or enacted by a legislative body.Biological Phenomena: Biological processes, properties, and characteristics of the whole organism in human, animal, microorganisms, and plants, and of the biosphere.Host-Parasite Interactions: The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Parasites: Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Plasmodium falciparum: A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.Pineal Gland: A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.Radiography, Dental, Digital: A rapid, low-dose, digital imaging system using a small intraoral sensor instead of radiographic film, an intensifying screen, and a charge-coupled device. It presents the possibility of reduced patient exposure and minimal distortion, although resolution and latitude are inferior to standard dental radiography. A receiver is placed in the mouth, routing signals to a computer which images the signals on a screen or in print. It includes digitizing from x-ray film or any other detector. (From MEDLINE abstracts; personal communication from Dr. Charles Berthold, NIDR)Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Universities: Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.Sleep Disorders: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Hospitals, University: Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.Students: Individuals enrolled in a school or formal educational program.Cardiology: The study of the heart, its physiology, and its functions.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)United StatesHeart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Cardiology Service, Hospital: The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Sleep Stages: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Bronchodilator Agents: Agents that cause an increase in the expansion of a bronchus or bronchial tubes.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Effects of endothelin on spontaneous contractions in lymph vessels. (1/75)

A mode of action of endothelin (ET) on spontaneous contractions was investigated in ring preparations of isolated bovine mesenteric lymphatics. ET-1 at concentrations between 10(-10) and 10(-9) M caused a dose-dependent increase in the frequency of spontaneous contractions. The specific ET(A)-receptor antagonist BQ-123 (5 x 10(-7) M) caused a significant inhibition of the ET-1-induced positive chronotropic effect in the ring preparations with and without the endothelium. Mechanical denudation of the lymphatic endothelial cells produced a significant potentiation of the ET-induced positive chronotropic effect. BQ-3020 (10(-8)-10(-7) M), a selective ET(B)-receptor agonist, induced dose dependently negative chronotropic and inotropic effects on the spontaneous contractions in the ring preparations with intact endothelium. Mechanical removal of the endothelium caused a significant reduction of the BQ-3020-induced negative chronotropic and inotropic effects. The ET-1-induced positive chronotropic effect was potentiated by pretreatment with N(omega)-nitro-L-arginine methyl ester (L-NAME) (10(-5) M) but unaffected by aspirin (10(-5) M). Additional treatment with L-arginine (10(-4) M) completely reversed the L-NAME-mediated potentiation of the ET-induced chronotropic effect. These results suggest that stimulation of ET(A) receptors on the lymphatic smooth muscles causes a positive chronotropic effect on the spontaneous contractions, and stimulation of ET(B) receptors on the lymphatic endothelial cells induces a release of nitric oxide, which results in the chronotropic and inotropic effects on spontaneous contractions in isolated bovine mesenteric lymphatics.  (+info)

Morningness/eveningness and the need for sleep. (2/75)

The purpose of this study was to determine, in a large sample of adults of all ages (17-80 years), the effect of morningness/eveningness on sleep/wake schedules, sleep needs, sleep hygiene and subjective daytime somnolence. A total of 617 subjects (219 subjects per chronotype group) matched for age, sex and employment status, completed an abridged morningness/eveningness questionnaire, a questionnaire on sleep habits and the quality of sleep, and the Epworth Sleepiness Scale. Eveningness was associated with a greater need for sleep, less time in bed during the week compared to ideal sleep needs, more time in bed at the weekend, a later bedtime and waking-up time especially at the weekend, more irregular sleep/wake habits and greater caffeine consumption. These subjects built up a sleep debt during the week and extended their duration of sleep at the weekend. They did not, however, rate themselves more sleepy than other types, despite the fact that our results showed a clear link between subjectively evaluated daytime somnolence and sleep debt. Why they were less affected by sleep deprivation is not clear. This raises the question of individual susceptibility to the modification of sleep parameters.  (+info)

Is the secretion of atrial natriuretic peptide in man under neural control? (3/75)

AIMS: Previous work has described short-term variation in the circulating plasma level of atrial natriuretic peptide (ANP), but the mechanism remains unknown. Our aim was to investigate the role of cardiac innervation in this variability. METHODS AND RESULTS: Blood samples were obtained from the right atrium via a pulmonary artery flotation catheter every 2 min over a 90 min period. Seven patients who underwent cardiac transplantation by the standard biatrial technique (partial innervation) and ten patients who underwent transplantation by the bicaval technique (total denervation) were studied. ANP levels were measured by radioimmunoassay. The median ANP levels were somewhat higher in the biatrial group compared to the bicaval group [470 (150-1095) vs. 216 (100-605) pg. ml(-1); median (range); P = ns], and both were much higher than normal levels in the pulmonary artery (40 (24, 56) pg ml(-1); median and interquartile range). In both transplant groups circulating plasma ANP levels showed considerable variability. The median number of 'peaks' and 'troughs', as counted by visual inspection, were not significantly different between the two groups. Computer analysis identified 12-16 and 6-15 'pulses' in the biatrial and bicaval group, respectively. Further analysis revealed that pulse amplitude, height and area were significantly higher in the biatrial compared to the bicaval group. CONCLUSION: It would appear that variability of circulating plasma levels of ANP is preserved despite complete or partial cardiac denervation, and so a neural mechanism does not appear to account for such variation.  (+info)

Basis for dosing time-dependent changes in the antiviral activity of interferon-alpha in mice. (4/75)

The influence of dosing time on the pharmacological effect (antiviral activity) of interferon-alpha (IFN-alpha), and the pharmacological and pharmacokinetic mechanisms, were investigated in ICR male mice under a 12-h light/dark cycle (lights on from 7:00 AM to 7:00 PM). 2'-5'Oligoadenylate synthetase activity in plasma at 24 h after IFN-alpha (10 MI.U./kg, i.v.) injection, as an index of antiviral activity, was significantly higher for injections given at 9:00 AM than for injections given at 9:00 PM (P <.05). The uptake of [(3)H]thymidine by lymphocytes after 24-h incubation with IFN-alpha, as an index of lymphocyte-stimulating effect, was significantly higher in cells obtained at 9:00 AM than in the cells obtained at 9:00 PM (P <.01). The number of receptors per cell and the expression of interferon-stimulated gene factor in lymphocytes after 24-h incubation with IFN-alpha were significantly higher in the cells obtained at 9:00 AM than at 9:00 PM (P <.05). A significant dosing time-dependent difference was demonstrated for the pharmacokinetic parameters of IFN-alpha, which showed higher clearance for injections given at 9:00 PM than for those at 9:00 AM (P <.05). The metabolism of IFN-alpha was significantly higher in kidney obtained at 9:00 PM than at 9:00 AM (P <.05). These findings support that choosing the most appropriate time of day for administration of IFN-alpha, associated with the rhythmicity of IFN-alpha receptor function and IFN-alpha pharmacokinetics, may increase the antiviral activity in experimental and clinical situations.  (+info)

Biological time and in vivo research: a field guide to pitfalls. (5/75)

Biological rhythmicity is a fundamental characteristic of all life forms, from primitive bacteria to man. The molecular biology, genetics, and the neurobiology of the biological clock(s) are being elucidated. Daily (circadian) statistically significant fluctuations occur in all of the normal biological variables studied in the experimental animal and the human. Many researchers, however, are not aware of the negative impact biological rhythmicity can have on experimental design and/or data interpretation. This article serves not as a review, but as a "field guide" to the pitfalls that can occur when research is performed in the absence of an understanding of biological rhythmicity. The major topics discussed are: 1) data transfer from the diurnally in-active/resting/sleeping lab animal to the diurnally active human, 2) frequency of sampling, 3) free-running vs. synchronization, 4) alternating periods of resistance and susceptibility, 5) phase shifting of a rhythm, 6) the assumption that one mean +/- S.E. from control animals can be "stretched" across an experimental time span, and 7) plotting data on an "hours after treatment" format vs. a "time of day" format. The hope is that by avoiding the pitfalls, biological time will become an ally in the endeavor to understand human biology.  (+info)

The temporal organization of life: the impact of multi-frequency non-linear biologic time structure upon the host-cancer balance. (6/75)

The current scientific paradigm, based upon an erroneous assumption of linear biologic reality and simple cause and effect relationships, has outlived its usefulness. In order to begin to turn the voluminous data the reductive process provides us with daily into meaningful understanding of life, it is essential to integrate these data within a complex, multi-frequency temporo-spatial framework. This rhythmic chronobiology more accurately depicts the life process, as well as its evolutionary and ongoing vital interaction with the pulsating cosmic resonance structure. Examples of the kinds of thinking and experiments necessary to exploit this new paradigm are provided.  (+info)

Diurnal variations of post-exercise parasympathetic nervous reactivation in different chronotypes. (7/75)

The purpose of this study was to investigate the diurnal variation and chronotype differences, i.e., in morning-types and evening-types, in post-exercise vagal reactivation. Twelve healthy male college students who were classified as morning-type (6) and evening-type (6), based on responses to a questionnaire, participated in this study. Postexercise vagal reactivation was assessed as the time constant of the beat-by-beat heart rate decrease for the first 30 sec after exercise (T30) at an intensity lower than the ventilatory threshold. The subjects performed 3-min cycle ergometer exercise at an intensity corresponding to 80% of the ventilatory threshold after a 1 min warm-up exercise in the morning (7:00 - 8:00) and evening (17:00 - 18:00) to obtain the T30. A significant interaction (chronotype-by-time) effect was found for T30. The morning value of the T30 in evening-type subjects was significantly larger than their evening value and the morning value in morning-type subjects. There was no significant interaction effect for heart rate and oxygen uptake during exercise. These results suggest that diurnal variation in post-exercise vagal reactivation is different between morning-type and evening-type, and post-exercise vagal reactivation in evening-type individuals is sluggish in the morning.  (+info)

The brain decade in debate: IV. Chronobiology. (8/75)

The present article is the adapted version of an electronic symposium organized by the Brazilian Society of Neuroscience and Behavior (SBNeC) which took place on June 14, 2000. The text is divided into three sections: I. The main issues, II. Chronodrugs, and III. Methods. The first section is dedicated to the perspectives of chronobiology for the next decade, with opinions about the trends of future research being emitted and discussed. The second section deals mostly with drugs acting or potentially acting on the organism's timing systems. In the third section there are considerations about relevant methodological issues concerning data analysis.  (+info)

Define biological time. biological time synonyms, biological time pronunciation, biological time translation, English dictionary definition of biological time. Noun 1. biological time - the time of various biological processes time - the continuum of experience in which events pass from the future through the...
Chronobiology is the study of biological rhythms. It examines the effects of time on biological events and internal biological clocks. Over the past few decades, chronobiology has developed into a multidisciplinary field of interest in general medicine and psychiatry (1). Research on chronobiology is constantly growing and has contributed to the development of an interdisciplinary field of research. The Nobel Prize in Medicine in 2017 was awarded to scientists who investigated molecular mechanisms that control circadian rhythms.. The earths rotation and the daily light-dark or day-night cycle have had long and constant biological impacts on the earths living organisms. Over the long evolutionary process, organisms have developed clock-like structures. These biological clocks help organisms successfully perform their activities over a 24-h cycle. This adaptive ability predicts cyclic changes and allows behavioral and physiological harmonization. These endogenous clocks are useful because they ...
The science of chronobiology quantifies the time structure characterizing each physiologic variable, its genetically anchored and mostly environmentally synchronized chronome. Thereby, one gains new information and thus a new dimension to the care of ones health and the integrity of ones environment. The importance of chronobiologic information has been compared with the importance of the energy released by splitting the atom. This science ushers in a new era by allowing one to do more than asking only whether a time-unspecified measurement or a series of such casual measurements or even a series of systematic measurements covering a day or a week is too high or too low. Instead, one can rely on a rhythm-adjusted mean (the MESOR) that as compared to the arithmetic mean is more accurate and more precise. As a dividend (which may be more important under certain conditions than the best average value), chronobiology also pro- vides new information on the extent of predictable since rhythmic changes (the
In life, timing is everything. There is a new buzzword in cancer therapy, Chronobiology. Simply put, this means the study of clocklike stuff in living things. Or you can use the brainier definition, Chronobiology is the quantitative study of rhythmic temporal relationships in biological phenomena. Our bodies go through a day as if multiple clocks were hardwired into our brains, organs, and very cells telling us what to do and when to do it. In recent years scientists have just begun to understand these multiple rhythms of activity and rest that different systems in the body go through on a daily basis. These daily, or circadian, cycles repeat themselves every 24 hours. Cells dont grow at a constant rate; rather there are bursts of frantic cell division followed by rest spells. Hormones are not generated at a steady flow rate but have high points when they are dumped into the blood and low points throughout the day. All animals have built in clocks in not just their bodies but in their ...
Canadian Society for Chronobiology provides an online community to network for all people interested and working in chronobiology in Canada and canadian chronobiologists presently outside of Canada.
Canadian Society for Chronobiology provides an online community to network for all people interested and working in chronobiology in Canada and canadian chronobiologists presently outside of Canada.
This investigation aimed to review the initial state of electrophysiological parameters that may predict the development of heart rhythm disorders in spontaneously-breathing pentobarbital-, ketamine-xylazine- and zoletil-anesthetized rats. These data will contribute to building a wider framework for a chronobiological perspective on the dependence of these parameters on the light-dark (LD) cycle under in vivo conditions. The study was performed using female Wistar rats, which were adapted to a 12 h LD cycle. Parameters evaluated included RR, PQ, QT, QTc intervals, the QRS complex and the amplitudes of P, R and T waves. The longest RR and QT interval duration occurred after the administration of ketamine-xylazine anesthesia in both the light period and the dark period. The longest PQ and QTc interval durations occurred under zoletil anesthesia in the light period. It is concluded that from a chronobiological perspective, the most significant electrophysiological myocardial susceptibility toward ...
Neurology: Chronobiology Differs Between Men and Women with Cluster Headache, Clinical Phenotype is organized by American Academy of Neurology (AAN) and will be held during Mar 14, 2017 - Mar 14, 2020.
AAPD Career Center: , Pullman, Washington , Postdoctoral Positions - Drug/Alcohol Addiction, Stress, Emotion, Chronobiology at Washignton State University, Department of Integrative Physiology and Neuroscience
What is the best time of day to train? And the one in which our brain is more concentrated? When it is better to apply creams and to dedicate oneself to beauty treatments and when to have a snack? Chronobiology helps you to. ...
Sports Chronobiology, An Issue of Clinics in Sports Medicine, 1e (The Clinics: Orthopedics) by Postolache MD, Teodor T. and a great selection of similar Used, New and Collectible Books available now at AbeBooks.com.
Available free of charge on the Internet 1. Cornélissen G, Halberg F. Introduction to Chronobiology. Medtronic Chronobiology Seminar #7. Minneapolis: Medtronic Inc.; April 1994, 52 pp. (Library of Congress Catalog Card #94-060580; URL http://www.msi.umn.edu/~halberg/) 2. Halberg F, Cornélissen G, International Womb-to-Tomb Chronome Initiative Group: Resolution from a meeting of the International Society for Research on Civilization Diseases and the Environment (New SIRMCE Confederation), Brussels, Belgium, March 17-18, 1995: Fairy tale or reality ? Medtronic Chronobiology Seminar #8, April 1995. Minneapolis: Medtronic Inc.; 1995. 12 pp. text, 18 figures. URL http://www.msi.umn.edu/~halberg/resol.html - - - Other: 3. Ahlgren A, Halberg F. Cycles of Nature: An Introduction to Biological Rhythms. Washington DC: National Science Teachers Association; 1990. 87 pp. 4. Ajuriaguerra J de (ed). Symposium Bel-Air III. Cycles biologiques et psychiatrie / publié sous la direction du professeur J. de ...
A. External cues (other than the entraining stimulus) that might provide timing stimuli to the animal should be avoided. This might seem axiomatic. For example, the most important entraining stimulus for mammals is light. As a result, most circadian biologists would not accept any phenomenon as circadian in nature unless it was demonstrated in continuous darkness (DD).. Nevertheless, this standard is often not observed. For example in the original studies demonstrating food entrainment (see review by Stephan [3]), animals were permitted to remain on a light-dark (LD) cycle. While the use of LD insured that the light entrained rhythm and the food entrained rhythm would remain temporally separated, the light also provides a temporal cue for food presentation. A number of recent food entrainment studies including those by Mistlberger in which he has done dorsomedial hypothalamic (DMH) lesions [4, 5], have continued to be performed only under LD. However, if animals are entrained under LD, and food ...
The evolving science of Chronobiology demonstrates that all body systems have a biorhythm or circadian rhythm that serve as physiological indicators that have a timing effect on specific systems metabolism. Nutrients and drugs give a more desired effect when given at a time that best matches this metabolism. This is called Chronobiology and is generating clinical studies that demonstrate certain drugs have a significantly different result if given in the AM as opposed to the PM. For example, since the liver is regenerating itself on a daily circadian basis in the early morning, antioxidants (i.e. Glutathione, N-Acetylcysteine) to help strengthen and support the liver are given in the IDNutrition™ PM packet. Because the pain of Osteoarthritis is generally late in the afternoon, the Joint and Inflammatory Support formulas are optimal if given in the IDNutrition™ AM packet. IDNutrition™ is delivering the optimal dose at the optimal time of day.. ...
The evolving science of Chronobiology demonstrates that all body systems have a biorhythm or circadian rhythm that serve as physiological indicators that have a timing effect on specific systems metabolism. Nutrients and drugs give a more desired effect when given at a time that best matches this metabolism. This is called Chronobiology and is generating clinical studies that demonstrate certain drugs have a significantly different result if given in the AM as opposed to the PM. For example, since the liver is regenerating itself on a daily circadian basis in the early morning, antioxidants (i.e. Glutathione, N-Acetylcysteine) to help strengthen and support the liver are given in the IDNutrition™ PM packet. Because the pain of Osteoarthritis is generally late in the afternoon, the Joint and Inflammatory Support formulas are optimal if given in the IDNutrition™ AM packet. IDNutrition™ is delivering the optimal dose at the optimal time of day.. ...
The evolving science of Chronobiology demonstrates that all body systems have a biorhythm or circadian rhythm that serve as physiological indicators that have a timing effect on specific systems metabolism. Nutrients and drugs give a more desired effect when given at a time that best matches this metabolism. This is called Chronobiology and is generating clinical studies that demonstrate certain drugs have a significantly different result if given in the AM as opposed to the PM. For example, since the liver is regenerating itself on a daily circadian basis in the early morning, antioxidants (i.e. Glutathione, N-Acetylcysteine) to help strengthen and support the liver are given in the IDNutrition™ PM packet. Because the pain of Osteoarthritis is generally late in the afternoon, the Joint and Inflammatory Support formulas are optimal if given in the IDNutrition™ AM packet. IDNutrition™ is delivering the optimal dose at the optimal time of day.. ...
How is the sleep/wake cycle maintained in plants? New research about plant proteins may help us to better understand the human circadian rhythm and human disease.
The applicant has a funded research program in medical chronoblology, is Associate Director of an NIH funded Harvard-wide Training Program in Sleep, Circadian &...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
What is the best time of day to train? And the one in which our brain is more concentrated? When it is better to apply creams and to dedicate oneself to beauty
Unlock the biological rhythm fat burning action of LPGs Body Shaping Gel to promote volume loss Dubai, UAE, 12th October 2017: The way our body works is simply amazing. Imagine, almost every organs in our body has a circadian clock ev
The suprachiasmatic nuclei (SCN) of the hypothalamus are the site of the body clock.29 These clusters of cells are linked to the eyes via the direct retinohypothalamic tract and receive a humoral input from the pineal gland, which secretes the hormone melatonin during the hours of darkness. Melatonin has many effects throughout the body, reviewed in an exercise physiology context by Atkinson et al.30 One of melatonins properties is that it is a potent vasodilator and so promotes heat loss. The evening fall of body temperature is caused by the body clock and the onset of melatonin secretion; the morning rise in body temperature is due to the combined effects of the body clock and an inhibition of melatonin secretion (secretion being suppressed by bright light). Melatonin induces drowsiness through its effect upon body temperature and also via a direct central action.. The rhythmic neural and humoral inputs to the SCN (showing a period of 24 h) enable the phase of the body clock to be adjusted to ...
The primary objective of the present study is to examine whether the combination of the antidepressant duloxetine and chronotherapeutic methods (including sleep deprivation, light therapy, and maintaining a regular sleep-wake rhythm) in patient with major depression, will induce an immediate improvement from depression and whether this antidepressive effect will be maintained in the long term (29 weeks). Patient will be randomised to the above mentioned treatment or to an active group receiving exercise ...
Ayurveda talks about biological time, which is the movement of life.. Dosha Kala means the times of each dosha. The bodys biological clock is regulated by the doshas. The time of maximum activity of kapha is during morning and evening from about 6 to 10 a.m. and 6 to 10 p.m. The pitta period is during midday and midnight, from about 10 a.m. to 2 p.m. and 10 p.m. to 2 a.m., while vata hours are dawn and dusk, from about 2 to 6 a.m. and p.m. Thus a pitta-type disease such as ulcers may cause the most discomfort late at night in pitta time. The reverse is also true, in the sense that experiencing a sharp pain in the stomach region late at night may signify ulcers or another pitta disorder.. Avastha Paka Kala means the time for the different stages of digestion, which is also biological time. When you eat food, it passes through various stages of digestion, each one governed primarily by one taste and a specific dosha. To digest a major meal takes approximately six hours or more. For the first ...
What mechanisms turn down (or off) cell metabolism and other cell functions? How does an animal such as an opossum know when to activate mechanisms for slowing or stopping tissue and organ functions? These capabilities raise important questions, which Peter Hochachka and Michael Guppy explore in this seminal new book. This is a pioneering book of great use to biomedical/clinical researchers and to biologists, biochemists, and physiologists generally.
Arbogast, Helmut; Hallek, M.; Arbogast, B. und Szinicz, L. (1987): Circadian variation of the atropine effect on the running performance of mice treated with 1,2,2-trimethylpropylmethylphosphonofluoridate (soman). 2. annual meeting of the European Society for Chronobiology, 1986, Marburg. [PDF, 969kB] ...
As chief of the division of sleep and chronobiology in the department of psychiatry at the University of Pennsylvania School of Medicine, David F. Dinges, Ph.D., focuses on ways sleep and the endogenous circadian pacemaker interact to control wakefulness and waking neurobehavioral functions such as physiological alertness, attention, cognitive performance, fatigue, mood, neuroendocrine profiles, immune responses and health. In an interview with Psychiatric Times, Dinges discussed neurobehavioral consequences of sleep loss, factors that impair sleeping, the pervasiveness of sleepiness and new ways to manage sleepiness. 1
The clock in the SCN is the major controller overall for timing, but when we face environmental mismatches that specifically involve the use of any particle/waveform tied to QED, it increases the likelihood that we can have desynchronization of the SCN from the peripheral clocks. It appears the brain has a dual timing mechanism. It has the older analog clock that responds in a graded fashion to one photon of light of many. The SCN and Pineal gland seem to be big players in the analog system. The retina and visual apparatus are the newer part of the clock called the digital system. They use a binary code of off and on with light. The action potential of the optic nerve is all or none. When light is present at the human eye ROS and ELF-UV light is released from cells. (van Wijk). When we have desynchronization of the SCN from the peripheral organ clocks, we call this a phase shift in chronobiology. This is how we lose track of Quantum time (small time) that I mentioned in EMF 6. Moreover, this ...
We approach these questions using cell culture models as well as mouse models of the innate immune system. One of our projects funded by the DFG addresses the circadian clock in macrophages: what are the mechanisms of immune regulation in these cells and what are the pathophysiological implications? Another project started just recently deals with the circadian clock in the host defense against malaria. This project is funded by the Human Frontier Science Program (HFSP) and is part of an international and interdisciplinary research effort, elucidating the evolutionary ecology of chronobiology in host-parasite interactions. ...
Ronald J. Konopka (1947-2015) was an American geneticist who studied chronobiology. He made his most notable contribution to the field while working with Drosophila in the lab of Seymour Benzer at the California Institute of Technology. During this work, Konopka discovered the period (per) gene, which controls the period of circadian rhythms. Ron Konopka received his Ph.D. in Biology from the California Institute of Technology in 1972. In 1975, following his discovery of the period mutants, Konopka was awarded a faculty position at the California Institute of Technology. While there, Konopkas colleagues were critical of his reluctance to publish his work on the period gene, and Konopka was denied tenure. After his stay at Caltech, Konopka accepted a position at Clarkson University but was again denied tenure and subsequently exited the field of science. Konopkas career, interwoven with the work of his mentor, Seymour Benzer, and the other scientists working in Benzers lab is narrated in Time, ...
V. Sheeba, M. Nihal, S. J. Mathew, N. M. Swamy, L. Bandhopadhyay, M. K. Chandrashekaran, A. Joshi and V. K. Sharma, Does the difference in the timing of eclosion of the fruit fly Drosophila melanogaster reflect differences in the circadian organization?, Chronobiology International 18, 601 - 612 (2001 ...
V. Sheeba, M. Nihal, S. J. Mathew, N. M. Swamy, L. Bandhopadhyay, M. K. Chandrashekaran, A. Joshi and V. K. Sharma, Does the difference in the timing of eclosion of the fruit fly Drosophila melanogaster reflect differences in the circadian organization?, Chronobiology International 18, 601 - 612 (2001 ...
Chiang CD, Lewis CL, Wright MD, Agapova S, Akers B, Azad TD, Banerjee K, Carrera P, Chen A, Chen J, Chi X, Chiou J, Cooper J, Czurylo M, Downs C, Ebstein SY, Fahey PG, Goldman JW, Grieff A, Hsiung S, Hu R, Huang Y, Kapuria A, Li K, Marcu I, Moore SH, Moseley AC, Nauman N, Ness KM, Ngai DM, Panzer A, Peters P, Qin EY, Sadhu S, Sariol A, Schellhase A, Schoer MB, Steinberg M, Surick G, Tsai CA, Underwood K, Wang A, Wang MH, Wang VM, Westrich D, Yockey LJ, Zhang L, Herzog ED. 2012. Learning chronobiology by improving wikipedia. J Biol Rhythms 27(4):333-6. PubMed abstract & fulltext for subscribers ...
Statement of Need Recent catastrophic bus and train accidents in the Bronx, New York, have highlighted the importance of understanding the negative effects of circadian sleep-wake disruption in shift workers, especially those in positions of responsibility for public safety, including bus and train operators and healthcare workers. Scientific evidence exists that manipulations by employers and employees can reduce the risk of errors due to sleep deprivation, so long as there is an understanding of underlying chronobiologic principles and the corresponding therapeutic options that can reduce and improve circadian disruption.. Activity Goal This program is designed to present the current understanding of chronobiology and the effects upon health and disease and to highlight the importance of circadian disruption on shift workers performances and productivity. Appropriate interventions can be undertaken by employers and employees to mitigate the effects of circadian disruption by manipulating ...
Bile acids (BAs), the most important endogenous and signaling molecules regulate the target transporters and enzymes at transcriptional level, participate in a wide variety of processes throughout the entire gastrointestinal tract to orchestrate homeostasis in vivo. BAs and their metabolism and transportation appear to follow the clear circadian rhythms, and they are recently proposed also as the potential chronobiological signals that can affect the molecular clock mechanism. Cholecystectomy are believed to affect the circadian rhythms of BAs and the relevant enterohepatic transporters and enzymes systems and their regulatory signaling pathways, for the reason that the circadian cycle of gallbladder filling and emptying play a pivotal role in controlling the flow of bile into the intestine and the enterohepatic circulation of BAs ...
The appropriateness of shift systems and individual coping techniques were discussed by a panel composed of members who have conducted research aimed at understanding how intervention techniques interact with performance and recovery of function. Each of the following topics was addressed by one of the members of this panel: manipulation of sleepiness by changing chronobiological napping, schedule
(Waking Times) The past of our ancestors lives on through us: Groundbreaking research illustrates how parental experience is not only epigenetically imprinted onto offspring, but onto an unprecedented number of future generations. Rather than occurring over the elongated time scale of millions of years, genetic change can transpire in real biological time through nanoparticles known as exosomes.
A great article from Nicholas Wade at the NYT:. "At the Salk Institute in La Jolla, Calif., scientists are trying to get time to run backward.. Biological time, that is. In the first attempt to reverse aging by reprogramming the genome, they have rejuvenated the organs of mice and lengthened their life spans by 30 percent. The technique, which requires genetic engineering, cannot be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.". Read more here.. ...
The first observation of top quark production in proton-nucleus collisions is reported using proton-lead data collected by the CMS experiment at the CERN LHC at a nucleon-nucleon center-of-mass energy of 8.16 TeV. The measurement is performed using events with exactly one isolated electron or muon and at least four jets. The significance of the ttbar signal against the background-only hypothesis is above five standard deviations. The measured cross section is 45±8 nb, consistent with predictions from perturbative quantum chromodynamics. We will discuss the experimental and theoretical aspects of this measurement including the potential probing of the time structure of the Quark Gluon Plasma with an analogous measurement in nucleus-nucleus collisions.. ...
receive the little categories on download intermediate algebra for( have ChronoTypes 5 and 6). different fluorescence of stock excavated by a introductory carcinoma to a dejellying of protein confirmed to the oxygen text. The time preparation is a place in one date and has to the supported experience at the rapid Inhibition.
Published in the journal BMC Biology, these results show for the first time that directly targeting the biological clock in a cancerous tumour has an impact on its development.. Most of the cells in the human body have an internal clock that sets a rhythm for the activities of our organs according to the time of the day. Cancer cells, however, often have a non-functioning or malfunctioning clock.. "There were indications suggesting that the malfunctioning clock contributed to rapid tumour growth, but this had never been demonstrated. Thanks to the use of a chemical or a thermic treatment, we succeeded in repairing these cells clock and restoring it to its normal functioning. In these conditions, tumour growth drops nearly in half," explains Cermakian, who is also Director of the Laboratory of Molecular Chronobiology at the Douglas Mental Health University Institute, one of the research centres of the CIUSSS de lOuest-de-lÎle-de-Montréal.. Although this preclinical demonstration was done ...
Research Interests:. Research focuses on species interactions and the influence of environmental factors on reproductive and feeding processes at various scales in benthic marine organisms. Major research areas include chronobiology, phenology, larval ecology, deep-sea biology, ocean acidification and aquaculture. ...
The MFPL fish facility provides maintenance and stock supply for the research groups working with both zebrafish (Danio rerio) and medakafish (Oryzias latipes). Both fish species have become attractive models for the molecular analysis of vertebrate development and physiology. The current facility is designed to host around 25,000 fish in more than 580 aquariums of different sizes. For chronobiological experiments and the study of light-dependent processes, the facility also provides special shelving systems that can be set to individual light regimes and light of different wavelengths. The MFPL fish facility includes laboratory space and equipment to perform high-throughput microinjections, transplantations or other micromanipulations. The facility organization including breeding and feeding routine is provided by a highly motivated animal care team and supported by the lab members of the Tessmar and Raible groups. ...
Except for a handful of forward-thinking school districts, the continuing resistance to starting high school later to accommodate the biological time clocks of teenagers speaks to the attitudes of the adults in charge of our children. How can it be that despite overwhelming evidence that sleep deprivation in teenagers is every bit the public health menace that cigarette smoking is, school administrators have abided the status quo?Sleep researchers have convincingly demonstrated that, on average, teenagers need nine hours of sleep and that their brains are programmed for them to stay up later than adults. Sleep researchers have also convincingly demonstrated that, on average, adults need eight hours of sleep. Not getting enough sleep is as pervasive in todays culture as was consuming two or three packs per day of Lucky Strikes in the 1940s, 50s and 60s. In reaction to a July 2010 Wall Street Journal article reporting the salutary effects of starting first period later at a Rhode Island prep ...
IN THOUSANDS OF CLINICAL STUDIES, HGH HAS BEEN SHOWN TO ACCOMPLISH THE FOLLOWING: * Reduce Body Fat and Build Lean Muscle WITHOUT EXERCISE! * Enhance Sexual Performance * Remove Wrinkles and Cellulite * Lower Blood Pressure and Improve Cholesterol Profile * Improve Sleep, Vision and Memory * Restore Hair Color and Growth * Strengthen the Immune System * Increase Energy and Cardiac Output * Turn back your bodys Biological Time Clock 10 - 20 years * Live Longer AND Stronger * All natural and organic plant based FEEL 10 YEARS YOUNGER WITH ORAL SPRAY HGH. GUARANTEED We are the manufacturer and we sell directly to Doctors, Chiropractors, and consumers world wide the highest grade HGH Oral Spray available. With internet marketing, we are able to save advertising cost and pass those savings along to you. But you must act now. To receive more information call us anytime (24hrs) TOLL FREE 1-888-621-7300 We must speak to you in person to qualify your usage. All of your questions will be addressed and ...
I should have known better; science marches onward, and old arguments get reexamined as new data arises. Steve Meyers book is a wonderful, comprehensive case that the origin of the major types of animals, namely the phyla, is just as strikingly discontinuous as the origin of life. As such, it represents a solid second volume complementary to his previous work, Signature in the Cell, which focused on the origin of life.. I had come to think that discussing the Cambrian Explosion was misguided because of two arguments: 1) that the explosion was merely an artifact of the fact that organisms before that time did not have hard bones or shells, and 2) that the explosion was short on the geological time scale, but was really quite long on the biological time scale. Meyer disposes of both of these arguments quite handily. On the first, modern science shows that soft-bodied organisms are well preserved in the strata before, during, and after the Cambrian. Also, many of the body types which appear in the ...
Internal Time book. Read 88 reviews from the worlds largest community for readers. Early birds and night owls are born, not made. Sleep patterns may be ...
Dennis Mills. Mills is the Deputy Director for X-ray Science at Argonnes synchrotron, the Advanced Photon Source. His main scientific interests are X-ray optics for synchrotron radiation applications and the use of the unique properties of synchrotron radiation, such as the polarization and modulated time structure, for studying condensed matter physics.. ...
Biological rhythms are driven by circadian oscillators, which are ultimately controlled by the cyclic expression of clock genes. Cryptochromes (CRY), blue light photoreceptors, belong to the negative elements of the transcriptional feedback loop into the molecular clock. This paper describes the cloning and characterization of two cryptochromes (cry1 and 2) in European seabass, which is considered an interesting chronobiology model due to its dual (diurnal/nocturnal) behavior. The cloned cDNA fragments encoded for two proteins of 567 and 668 amino acids, which included the FAD-binding and the DNA-photolyase domains. Moreover, both proteins had a high homology with cryptochrome proteins (Cry) of other teleost fish. These cry1 and 2 genes were expressed in several tissues of seabass (brain, liver, heart, retina, muscle, spleen, gill and intestine). In addition, the daily expression of cry1 was rhythmic in brain, heart and liver with the acrophase around ZT 03:15 h (after the onset of lights). ...
25 Jul. 2013 Full moon can mess with your sleep, new study finds- Meghan Holohan- NBC News Health Though this news article is a little older though the research results are still interesting. Cajochen, a professor and director of the Centre for Chronobiology at the University of Basel in Switzerland studied an old experiment from 2000 to 2003 that examined circadian rhythms and the sleep- wake cycle. The experiment included 17 healthy young volunteers between age 20 and 31 and 16 healthy older subjects between the ages 57 to 74. At the time, the study had nothing to do with lunar cycles and sleep. Though as Cajochen looked at this study again, he found that people experienced better sleep during the new moon and worse sleep during a full moon. During the full moon, it takes an average of five minutes longer to fall asleep and people dozed for 20 minutes less. And, their melatonin levels dropped. Melatonin is a hormone that regulates the sleep-wake cycle by causing drowsiness and a dip in body ...
How We Tick. At last, the Chrononutrition and Biorhythm science that IDNutrition has been utilizing since its inception is now working its way into medicine.. U.S. scientists Jeffrey Hall, Michael Rosebush and Michael Young received the 2017 Nobel prize for Medicine for unraveling of molecular mechanisms that control our bodys internal clocks.. Chronopharmacology (also known as Chronobiology) is the study of biological clocks and is now a growing field of research thanks to the pioneering work of these three scientists. Their work uncovered the role of specific genes in fruit flies that keep the body synchronized with light changes. "This ability to prepare for the regular daily fluctuations is crucial for all life forms," Thomas Perlmann, secretary of the Karolinska Institute Nobel Committee, told reporters.. "This years Nobel prize laureates have been studying this fundamental problem and solved the mystery of how an inner clock in our bodies can anticipate daily fluctuations between night ...
The granulocytes reacted immediately to the physical stress of sleep loss and directly mirrored the bodys stress response," said Ackermann, a postdoctoral researcher at the Eramus MC University Medical Center Rotterdam in the Netherlands. The study, "Diurnal Rhythms in Blood Cell Populations and the Effect of Acute Sleep Deprivation in Healthy Young Men," was a collaborative effort between the Department of Forensic Molecular Biology at Erasmus MC University Medical Center Rotterdam and Chronobiology, Faculty of Health and Medical Sciences at the University of Surrey, United Kingdom. The laboratory study was conducted at the University of Surrey Clinical Research Centre.. For a copy of the study or to arrange an interview with an AASM spokesperson, please contact PR Coordinator Doug Dusik at 630-737-9700, ext. 9364, or [email protected] The monthly, peer-reviewed, scientific journal SLEEP is published online by the Associated Professional Sleep Societies LLC, a joint venture of the American ...
Irish Health Research Board; Leukaemia Research Fund; Medical Research Council (MRC); National Awareness and Early Diagnosis Initiative (Department of Health & Cancer Research UK); National Institute for Health Research (NIHR); OTKA-EPR (Hungarian Research Board). Member of editorial board: Spatial and Spatio-temporal Epidemiology Reviewer for the following journals: Acta Neurochiruga; African Journal of Biotechnology; American Journal of Epidemiology; Applied Statistics; Archives of Disease in Childhood; Birth Defects A: Clinical and Molecular Teratology; Blood; BMC Cancer; BMC Public Health; British Journal of Cancer; British Journal of Haematology; British Medical Journal; Cancer Causes and Control; Cancer Detection and Prevention; Cancer Epidemiology; Cancer Epidemiology, Biomarkers and Prevention; Child: Care, Health and Development; Chronobiology International; Clinical Microbiology and Infection; Developmental Medicine and Child Neurology; Diabetic Medicine; Diabetes Research and Clinical ...
Melatonin is a hormone that takes part in the regulation of biological rhythms. It is produced in the pineal gland and is stimulated by darkness and inhibited by exposure to light. The increased amouot of melatonin during the hours of darkness sends a chronobiological message throughout the body, and translates it into a chemical message that can be read by target cells. This process requires that a receiving protein, a receptor, is present on the cell surface, and that it can recognize melatonin and transfer the signal from outside of the cell to the inside, where it can be transformed into a cellular response. The present investigation was focused on receptor recognition, receptor activation and receptor-mediated signaling.. The scales of the cuckoo wrasse (Labrus ossifagus L.), a teleost fish, bear melanophores that contain pigment granules that can be transported to the center of the cell (pigment aggregation) or distributed throughout the melanophore (pigment dispersion). Pigment ...
Title: Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy. VOLUME: 2 ISSUE: 2. Author(s):David E. Blask, Leonard A. Sauer and Robert T. Dauchy. Affiliation:Laboratory of Experimental Neuroendocrinology / Oncology, Bassett Research Institute, One Atwell Road, Cooperstown, NY 13326, USA. Keywords:Circadian-Based Cancer Therapy, 13-hydroxyoctadecadienoic acid (13-HODE), Estrogen Response Pathway, glutathione (GSH), Chronobiological. Abstract: Melatonin, as a new member of an expanding group of regulatory factors that control cell proliferation and loss, is the only known chronobiotic, hormonal regulator of neoplastic cell growth. At physiological circulating concentrations, this indoleamine is cytostatic and inhibits cancer cell proliferation in vitro via specific cell cycle effects. At pharmacological concentrations, melatonin exhibits cytotoxic activity in cancer cells. At both ...
The advantages of the field of chronotherapy are endless. If we can properly time our use of drugs to follow the circadian rhythms of disease, we are able to increase the efficacy and effectiveness of common pharmaceuticals, while decreasing toxic side effects. For example, the knowledge that our blood pressure increases during wakefulness and decreases at sleep time is common. However, taking it one step further, we find that patients with chronically high blood pressure do not follow the same rhythm: it stays at a constant high throughout the day which weakens their heart and blood vessels and progresses to heart failure. The preferred treatment for these patients is ACE inhibitors which are a class of drugs that work to decrease blood pressure. Patients are usually instructed to use them during the day, however, a study by Martino et al. found that administering the ACE inhibitor, captopril, is significantly more effective at sleep-time than at wake-time in hypertensive models. It is thus ...
The transition of the human uterus from a quiescent to a contractile state takes place over a number of weeks. On such biological time scales, cellular phenotype is modified by changes in the transcriptome, which in turn is under the control of the underlying endocrine, paracrine, and biophysical processes resulting from the ongoing pregnancy. In this study, we characterize the transition of the human myometrial transcriptome at term from not in labour (NIL) to in labour (LAB) using high throughput RNA sequencing (RNA-seq). RNA was isolated from the myometrium of uterine biopsies from patients at term who were not in labour (n = 5) and at term in spontaneous labour (n = 5) without augmentation. A total of 143.6 million separate reads were sequenced, achieving, on average, ∼13 times coverage of the expressed human transcriptome per sample. Principal component analysis indicated that the NIL and LAB transcriptomes could be distinguished as two distinct clusters. A comparison of the NIL and LAB ...
Prior to this, I was a Wellcome Trust funded 1+3 year (MSc+PhD) doctoral student at Imperial College, supervised by Profs. Michael Stumpf and Sylvia Richardson. After completing the MSc component with Distinction, I started my PhD in October 2007. Additionally working with Charles Bangham (Immunology) and Alexandra Lewin (Biostatistics), I investigated and developed stability selection approaches for proteomic biomarker discovery in the context of HTLV-1 associated myelopathy/tropical spastic paraparesis. I also considered the use of Gaussian process regression models for quantifying the robustness of inferences drawn from biological time course data. For my PhD, I was awarded the Centenary Prize for Research in the Molecular Biosciences ...
Topics to be covered in the WHJ include the following: Epidemiology and Prevention, Chronocardiology and Chronomics, Nutrition and Lifestyle in CVD, Clinical Cardiology, Cardiovascular Sciences (Molecular Cardiology: biochemistry and biology), Hypertension, Coronary artery disease, Pharmacotherapy, Electrophysiology, Echocardiography, Nuclear Cardiology, Pediatric Cardiology, Geriatric Cardiology, CVD in women, Cardiac Rehabilitation and Prehabilitation, as well as Interventional Cardiology and Cardiac surgery ...
The Jet Lag Treatment Pack prevents jet lag symptoms and helps to adjust sleeping patterns to different time zones. Buy this treatment safely online at euroClinix.net
The advent of the ultra-long-haul flight means that meeting planners need to get creative in dealing with this modern menace. Dealing with jet lag can be challenging, but fear not-were here to help with some innovative ideas for tackling it.
1Above is a drink working to combat all of the inconveniences of jet lag. The brand has recently released the drink in United States and Canada in
Melatonin, better known as the hormone of darkness, is secreted by the pineal gland during the night and helps us fall asleep. Because its internal regulation depends on light, melatonin is part of chronobiology, the study of biological mechanisms and their adaptations to lunar and solar related rhythms (Klein et al. 1991). Therefore, photoperiod changes greatly impact melatonin concentration, influencing changes in neuronal and hormonal mechanisms of the photo neuro-endocrine systems, namely reproduction. Research has shown that a disruption in the circadian rhythm of melatonin due to photoperiod changes detrimentally affects the rhythmic function of the female reproductive cycle. Research from journals, articles, and printed books has shown that both exogenous and endogenous features contribute to the reproductive cycle and that the internal mechanisms are entrained by environmental cues. Photoresponsiveness of the reproductive system is mediated by the internal biological clock, transcriptional
J Physiol. 2001 Aug 15;535(Pt 1):261-7. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans.. Thapan K, Arendt J, Skene DJ.. Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.. 1. Non-image forming, irradiance-dependent responses mediated by the human eye include synchronisation of the circadian axis and suppression of pineal melatonin production. The retinal photopigment(s) transducing these light responses in humans have not been characterised. 2. Using the ability of light to suppress nocturnal melatonin production, we aimed to investigate its spectral sensitivity and produce an action spectrum. Melatonin suppression was quantified in 22 volunteers in 215 light exposure trials using monochromatic light (30 min pulse administered at circadian time (CT) 16-18) of different wavelengths (lambda(max) 424, 456, 472, 496, 520 and 548 nm) and irradiances (0.7-65.0 microW ...
TY - CONF. T1 - Electromagnetic pulser for the investigation of cell membranes. AU - Doria, A.. AU - Gallerano, G.P.. AU - Giovenale, E.. AU - Messina, G.. AU - Spassovsky, I.. PY - 2011. Y1 - 2011. N2 - An electron based radiation source is presented with the aim of irradiating cell membrane models and biological cell membranes. The peculiarity of the device is that it can simultaneously generate short electromagnetic pulses, in the millimeter wave range, and electrostatic pulses with the same time structure. © 2011 IEEE.. AB - An electron based radiation source is presented with the aim of irradiating cell membrane models and biological cell membranes. The peculiarity of the device is that it can simultaneously generate short electromagnetic pulses, in the millimeter wave range, and electrostatic pulses with the same time structure. © 2011 IEEE.. UR - http://www.scopus.com/inward/record.url?scp=84855867325&partnerID=8YFLogxK. UR - ...
All the children had previously received DMARDs (66.6% methotrexate (MTX) and 33.3% MTX and sulfasalazine). Eight of the 9 patients (88.9%) were taking corticosteroids at baseline. Eight received etanercept (ETN) and one Adalimumab (ADA), with good outcomes in all the patients unless 1 that had to switch from ETN to ADA due to inefficacy, and improved after the change. The steroids were suspended in 75% of children (6). Differences between mean values of CRP, ESR, and platelets from baseline to actual moment were statistically significant.. The median biologic time is 4 (1.11) years.. Actually all the children are in remission, two of them (patients 1 and 4) without biological treatment or classic DMARDs (since 5 and 2 years respectively).. None of the children have had significant adverse effects nor required hospitalisation from the beginning of therapy. ...
The molecular clock: a focus on chronopharmacological strategies for a possible control of aminoglycoside renal toxicity Marcela RebueltoFarmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, ArgentinaAbstract: Chronotherapy applies biological rhythmicity in order to optimize clinical treatments, relating the dosing time of the drugs to the daily variations of their therapeutic and unwanted side effects due to the fluctuations in physiological processes involved in their pharmacokinetics and/or pharmacodynamics. The goal of chronotherapy is to administer treatments at the time of day that enhances both their effectiveness and tolerance. This review intends to (1) provide the theoretical rationale behind the use of aminoglycosides during extended interval schedule chronotherapy in clinical practice and (2) target the underlying molecular mechanisms of renal toxicity, the main unwanted side effect. Previous reports suggest that aminoglycoside therapy may benefit
With the rapid growth in the number of solved protein structures stored in the Protein Data Bank (PDB) and the Electron Microscopy Data Bank (EMDB), it is essential to develop tools to perform real‐time structure similarity searches against the entire structure database
Get information, facts, and pictures about Jet lag at Encyclopedia.com. Make research projects and school reports about Jet lag easy with credible articles from our FREE, online encyclopedia and dictionary.
The first time I heard about the biological rhythms of a man was from a scientific adviser, Doctor of Psychology, Professor V. Klimenko. He described how, as a psychologist for the Soviet national chess team, he served the world champion Anatoly Karpov. It was then, according to him, the study of the basic biological rhythms of man was actively conducted. Professor Klimenko said there were even detective stories around the most successful dates for the three main biological rhythms of Karpov. Their team was trying to fix the date of the match, so they tried to set the date on these most successful dates for their athlete and on the most unfortunate dates for his opponent. And the opposing team, on the contrary, knowing and studying the same questions, tried to. counter these intentions and tried to win for themselves their most favorable days, and the unsuccessful days for the Soviet chess player. Professor Klimenko suggested that his calculations and conclusions, sometimes altered the fate of ...
Jet Lag problems: I travel a lot and always struggle with jet lag. How would melatonin help and how many times is it safe to take this? Can you get addicted...
Just before I left on vacation, a mother of a child in my practice asked me why it was so hard for her 6-yo son to make transitions. I was rushing to get ready to leave, so I sent her a quick email promising to respond more fully when I had a chance to think about it. I have had her question in the back of my mind and was especially struck by it when I arrived in Europe and experienced jet lag. It occurred to me that jet lag was a good metaphor for the kind of transition the mother was asking about.. First of all, her child is one of those highly sensitive children I refer to as "race horses", of others in the literature have called "orchids". He is extremely intelligent but sometimes retreats to infantile behavior patterns, and he often reacts with extreme distress in the context of transitions - even simple daily transitions such as getting up and getting ready for school in the morning or leaving play to go somewhere or do something else. This problem is interesting because it gets mixed up ...
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Your body has an internal clock that helps regulate when you eat and sleep, and even how you feel. Read on to learn more about biological rhythms.
If stories traditionally mimic the birth, growth and death of nature with a beginning, middle and end, what happens to stories in cyberspace ...
This plant can be weedy or invasive according to the authoritative sources noted below.This plant may be known by one or more common names in different places, and some are listed above. Click on an acronym to view each weed list, or click here for a composite list of Weeds of the U.S. ...
Not so smart after all: Memories of what you learned and experienced yesterday are consolidated during REM sleep. Deep sleep may also be involved in this process. Disrupted sleep means disrupted learning. Difficulty with weight management: Sleep disruption affects the hormones that regulate hunger as well as our level of physical activity. Recurrent sleep deprivation increases our desire for high-calorie foods and may make us more prone to weight gain, research suggests. A 2006 study found that each hour of social jet lag was associated with a 33 percent higher risk of obesity.. Infections: Ongoing sleep deprivation and disruption are associated with weakened immune function, potentially leaving us less able to fight off viruses like the common cold.. Temptation to drink and smoke: Social jet lag is a risk factor for more than academic failure; it can also lead to increased use of alcohol, cigarettes, and caffeine, according to a 2006 study in Chronobiology International.. Accident-prone: ...
Dr. Alfred J. Lewy reviews medical content for Healthwise, a nonprofit organization with a mission to help people make better health decisions. Dr. Lewy is the Richard H. Phillips Professor of Biological Psychiatry at the Oregon Health and Science University School of Medicine in Portland, Oregon. He is also a Professor of Ophthalmology, Physiology, and Pharmacology. He serves as Senior Vice Chairman of the Department of Psychiatry and is the Director of the Sleep and Mood Disorders Laboratory at Oregon Health and Science University School of Medicine. Dr. Lewy is an internationally recognized pioneer in the field of human chronobiology. He has made major contributions to the study of melatonin physiology and light as they relate to depression, seasonal affective disorder, jet lag, and sleep disorders.. ...
Chronotherapy for rheumatoid arthritis: current perspectives Hideto To Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder of unknown etiology. Morning stiffness, a characteristic feature of RA, shows a 24-hour rhythm. Cytokines, which are considered to play an important role in the pathogenesis of RA, also exhibit a 24-hour rhythm, with a peak in the early morning. These rhythms have been attributed to the endogenous hormone balance and changes in expression levels of clock-related genes. Chronotherapy based on the 24-hour rhythm of RA has been performed using glucocorticoids and disease-modifying antirheumatic drugs. In a previous study, it was reported that modified-release prednisone tablets were administered to patients with RA at night, which demonstrated that the severity of morning stiffness was markedly less than that in patients receiving the
Challenging the human circadian clock by daylight saving time and shift-work [Elektronische Ressource] / written by Thomas Kantermann : Challenging the human circadian clock by Daylight Saving Time and Shift-Work Academic Dissertation (Doctor rerum naturalium) At the Centre for Chronobiology Institute for Medical Psychology Ludwig-Maximilians-University Munich Written by Thomas Kantermann thBorn 26 of February, 1979 in Gütersloh Arbeit eingereicht am: 17.07.2008 1. Gutachter / Prüfer: Prof. Gisela Grupe 2. Gutachter /
Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has renowned regulatory roles in the control of circadian rhythm and exerts its physiological actions primarily by interacting with the G protein-coupled MT1 and MT2 transmembrane receptors. The two melatonin receptor subtypes display identical ligand binding characteristics and mediate a myriad of signaling pathways, including adenylyl cyclase inhibition, phospholipase C stimulation and the regulation of other effector molecules. Both MT1 and MT2 receptors are widely expressed in the central nervous system as well as many peripheral tissues, but each receptor subtype can be linked to specific functional responses at the target tissue. Given the broad therapeutic implications of melatonin receptors in chronobiology, immunomodulation, endocrine regulation, reproductive functions and cancer development, drug discovery and
... allintitle: Google Web Sarches filetype:ppt. 49,722 Total for Life Sciences 0 for Aerobiology. 17,700 for Anatomy. 5 for Animal communication. 1,430 for Biochemistry. 1,990 for Bioinformatics. 927 for Biological systematics OR taxonomy. 8,640 for Biology. 46 for Biophysics. 99 for Botany. 251 for Cell biology. 2 for Chronobiology. 16 for Comparative anatomy. 0 for Cryobiology. 0 for Cryptozoology 29 for Developmental biology. 3,010 for Ecology. 98 for Embryology. 88 for Endocrinology. 93 for Entomology. 15 for Ethnobotany. 17 for Ethology. 19 for Evolutionary biology. 3,950 for Genetics. 8 for Herpetology. 348 for Human anatomy. 47 for Human biology 14 for Human ecology. 82 for Human physiology 8 for Ichthyology. 30 for Landscape ecology. 287 for Life sciences. 15 for Limnology. 0 for Linnaean taxonomy. 62 for Marine biology. 1,180 for Microbiology. 449 for Molecular biology. 1 for Molecular virology. 36 for Mycology. 564 for Neuroscience. 4,140 for Nutrition. 0 for Oology. 6 for ...
MarketSizeForecasters.com adds a new "Global Jet Lag Therapy Market Research Report 2017" new report to its research database. The report spread across 103 pages and 115 table and figures in it. The report provides information on industry trends, demand, top manufacturers, countries, material and application.. Global Jet Lag Therapy Market Research Report 2017 estimates the drivers, restraints, and opportunities pertaining to the global Jet Lag Therapy market over the timeframe of 2016-2022. Delivering the key insights pertaining to this industry, the report provides an in-depth analysis of the latest trends, present and future business scenario, market size and share, and commercialization potential of the Jet Lag Therapy industry over the coming five years.. Request a Free sample PDF of this research to evaluate more @ https://marketsizeforecasters.com/get-sample/359427/?utm_source=SPR-SP. The competitive landscape of the Jet Lag Therapy market profiles the key players participating in the ...
Several types of depression such as bipolar disorder, seasonal affective disorder and subforms of major depressive disorder are known to be associated with deviations in the circadian system, alterations that are crucial to the etiology of these pathologies. Therefore, entrainment of circadian rhythms is regarded as a promising basis for treatment. The rules for successful synchronization by melatonin are outlined. Differences of phase resetting within the phase response curve are emphasized. Moreover, deviations from classic pharmacological thinking are underlined. When appropriately timed, relatively low doses are sufficient for entrainment, whereas increases of doses may reduce rather than improve the success of resynchronization. Immediate-release formulations are sufficient and recommendable, since they generate synchronizing signals that are favorable with regard to their time structure, whereas extended actions as desired in classic pharmacology of antidepressants may prevent successful ...
In the atmosphere, feldspar particles act as ice nuclei that make ice crystals grow in clouds and enable precipitation. The reason was found by researchers of Karlsruhe Institute of Technology (KIT) and University College London (UCL) with the help of electron microscopy observations and molecular dynamics computer modeling. The ice nucleus proper is a quasi-hidden crystal surface of the feldspar that is exposed at surface defects only. The researchers present their findings in Science.
The illustration above is adapted from Till Roenneberg et al., the team who invented the Munich Chronotype Questionnaire, MCTQ. The MCTQ is a modern version of the Morningness-eveningness Questionnaire, MEQ, and it is considered to give the best estimate of morningness and eveningness chronotypes. They have chosen to consider sleep onset at 00:30 and 01:00 as
Melatonin. One of the best ways to alleviate jet lag is to take melatonin. This natural hormone plays a major role in synchronizing the body clock with the external environment. One major review concluded that 2-5 mg of melatonin, taken at bedtime after arrival for two to four days-together with the non-drug measures listed in the box below-can minimize jet lag (BMJ, 2003; 326: 296-7). But timing of the dose is important: if taken at the wrong time early in the day, it can cause sleepiness and delay adaptation to the local time (Cochrane Database Syst Rev, 2002; 2: CD001520).. However, melatonin is difficult to get hold of in the UK and other European countries, although it is freely available in the US, Thailand and Singapore.. Adverse effects are rare, but some report sleepiness, headache, feeling heavy-headed or hungover, stomach dis-comfort or depression. Those taking warfarin or other oral anticoagulants, and those with epilepsy would do best to avoid melatonin (BMJ, 2003; 326: 296-7). ...
Cancer, Circadian Timing System, Patients, Therapeutic, Anorexia, Biorhythms, Colorectal Cancer, Cytokines, Fatigue, Rest, Treatments, Wrist, Administration, Apoptosis, Biology, Cell Cycle, Chronotherapy, DNA, DNA Repair, Down Regulation
Jet lag and shift work impose painful changes on the bodys circadian rhythms. Adjusting oxygen consumption might help, researchers say. But dont hold your breath; its only been tested in mice.
Studies show that shift work and other sleep disturbances like jet lag can disrupt your body clock and increase the risks of obesity and diabetes. But, until now, researchers havent really been sure exactly how these changes affect the bodys metabolism. To find out, Dr.
Studies show that shift work and other sleep disturbances like jet lag can disrupt your body clock and increase the risks of obesity and diabetes. But, until now, researchers havent really been sure exactly how these changes affect the bodys metabolism. To find out, Dr.
A new study in mice suggests an unlikely cure for jet lag: oxygen deprivation. When the animals breathed air with about one-quarter to one-third less...
Memory Learn how scent, jet lag, and estrogen affect memory, plus plenty of other information, with these facts. Jet lag. Frequent jet lag can impair your memory, probably due to the stress hormones released. New connections. Every time you recall a memory or have a new thought, you are creating a new connection in your…
Patients receiving chemical treatment for cancer often suffer fatigue and body weight loss, two of the most worrying effects of this therapy linked to the alteration of their circadian rhythms.
Thanks so much for posting these Barbara. They really give a sense of the intimate nature a performance like this achieves. I was struck by the stories that came out of the between song banter. Really fills in the gaps of the meaning behind these songs I love so much ...
Delta is testing a large photon shower thats supposed to help cure frequent fliers of their jetlag. How does it work -- and is it safe? AllThingsDs Lauren Goode reports from the D11 conference.
Wu, C. W., Tsai, P. J., Chen, S. C. J., Li, C. W., Hsu, A. L., Wu, H. Y., Ko, Y. T., Hung, P. C., Chang, C. Y., Lin, C. P., Lane, T. J. & Chen, C. Y., 十月 1 2019, 於 : Sleep and Biological Rhythms. 17, 4, p. 423-431 9 p.. 研究成果: 雜誌貢獻 › 文章 ...
A compulsion to consume as much as possible of a particular website, then tell your friends about it so that youre not the only one who spent all day r...
This book on the role of melatonin in psychiatric and neoplastic disorders is edited and written by prominent researchers in their respective fields from universities in the United States and Canada. The purpose is to review the current state of knowledge about the hormone melatonin and its potential role in psychiatric disorders such as depression, sleep and eating disorders, and the possible role of melatonin in neoplastic disorders. The primary audience includes adult, child, and adolescent psychiatrists, oncologists, endocrinologists, pediatricians, and other health professionals. Appropriate figures, graphs, and tables are included to illustrate the text. The article references are extensive and up-to-date. Melatonin is a hormone secreted by the pineal gland. Receptors for melatonin are found not only in the brain but also in cells in other parts of the body. This book reviews the role melatonin plays in psychiatric disorders such as major depression, sleep disorders, chronobiological mood ...
Geriatric animal models are crucial for a better understanding and an improved therapy of age-related diseases. We observed a high mortality of aged mice after anesthesia with a standard dose of ketamine/xylazine, an anesthetic regimen frequently used in laboratory veterinary medicine. C57BL/6-N mice at the age of 2.14 ± 0.23 months (young mice) and 26.31 ± 2.15 months (aged mice) were anesthetized by intraperitoneal injection of 2 mg ketamine and 0.2 mg xylazine. 4 of 26 aged mice (15.4%) but none of 26 young mice died within 15 min after injection of the anesthetics. The weight of aged mice was significantly higher than that of young mice (32.8 ± 5.4 g versus 23.2 ± 3.4 g, p | 0.0001). Thus, aged mice received lower doses of anesthetics in relation to their body weight which are within the lower range of doses recommended in the literature or even beneath. There were no differences between deceased and surviving aged mice concerning their sex, weight and their motor performance prior to anesthesia
Voluntary health organizations active in the prevention or treatment of diseases or conditions that affect the nerves, muscles or bones. Use this code for organizations that focus on a wide variety of nerve, muscle and bone diseases or those not specified below. The related medical specialty is orthopedic surgery.. Key words: ALS; Amyotrophic Lateral Sclerosis; Arnold Chiari Syndrome; Arthrogryposis; Atrophic Muscular Disorders; Autonomic Nervous System Diseases; Batten Disease; Bell Palsy; Bells Palsy; Bone Diseases; Bursitis; Cartilage Diseases; Central Nervous System Diseases; Chronic Fatigue Syndrome; Chronobiology Disorders; Circadian Rhythm Sleep Disorders; Connective Tissue Diseases; De Quervain Disease; Dysautonomia; dystonia; Fibromyalgia; Guillain-Barre Syndrome; Hemiplegia; Jet Lag Syndrome; Joint Diseases; Lou Gehrig Disease; Miller Fisher Syndrome; Mitochondrial Myopathies; MS; Multiple Sclerosis; Muscular Diseases; Muscular Dystrophy;Muscle Diseases; Musculoskeletal & Connective ...
Could breathing reduced oxygen help warfighters recover from jet lag faster? In an effort to find out, U.S. Army and U.K. researchers recently conducted a jet lag study on British warfighters who traveled to the lush rainforests of Brunei.
ABSTRACT. Chronopharmaceutics is a branch of pharmaceutics devoted to the design and evaluation of drug delivery systems that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given disease therapy. A major objective of chronotherapy in the treatment of several diseases is to deliver the drug in higher concentrations during the time of greatest need according to the circadian onset of diseases or symptoms. The main objective of the present study is to develop single-unit pulsatile drug delivery system for obtaining no drug release till it reaches in colon followed by pulsed drug release in colon to achieve chronotherapeutic release of atenolol for treatment of hypertension and to improve the patient compliance. In vitro studies revealed that the tablet coated with guar gum and Eudragit S-100 have limited drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. Programmable pulsatile, ...
Chronobiology - field of biology that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar- ... Theoretical Biology - the mathematical modeling of biological phenomena. Zoology - study of animals, including classification, ...
The two animal experiments were entitled Chronobiology of Pocket Mice and Circadian Rhythm in Vinegar Gnats. Both experiments ... additional information about fluid distribution and fluid balance to get a better understanding of the fluid shift phenomena. ...
New models, such as the soliton model attempt to explain these phenomena, but are less developed than older models and have yet ... Also improbable possibility of modelling of local chronobiology mechanisms.. *Modern views regarding of the role of the ... The shortcomings of the model is its inability to reflect properly the following phenomena:. *The edge emphasizing property of ...
... and wildlife Chronobiology - field of biology that examines periodic (cyclic) phenomena in living organisms and their ... and wildlife History of chronobiology - history of the field of biology that examines periodic (cyclic) phenomena in living ... History of quantum physics - history of the branch of physics dealing with physical phenomena where the action is on the order ... Quantum mechanics - branch of physics dealing with physical phenomena where the action is on the order of the Planck constant. ...
... chronobiology), the alignment of a circadian system's period and phase to the period and phase of an external rhythm ... a phenomenon of the atmosphere Entrainment (physical geography), the process by which surface sediment is incorporated into a ...
... is a field of biology that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar ... "Father of Chronobiology" The University of Virginia offers an online tutorial on chronobiology. See the Science Museum of ... Chronobiology comes from the ancient Greek χρόνος (chrónos, meaning "time"), and biology, which pertains to the study, or ... Chronobiology is an interdisciplinary field of investigation. It interacts with medical and other research fields such as sleep ...
In: Trends in Chronobiology, ed. Hekkens W, Th JM, Jerkhof GA and Rhietveld WJ, Pergamon Press, Oxford and New York, pp. 149- ... The term Aschoff used for this phenomenon is "arousal" due to non-photic zeitgebers. Data from experimental assays show a ... Together with Erwin Bünning and Colin Pittendrigh, he is considered to be a co-founder of the field of chronobiology. Aschoff's ... Aschoff's work in the field of chronobiology introduced the idea that shifting one's light-dark cycle can result in harmful ...
Rosenthal and his colleagues then documented the phenomenon of SAD in a placebo-controlled study utilizing light therapy. A ... Chronobiology International: the Journal of Biological & Medical Rhythm Research. 31 (4): 523-531. doi:10.3109/07420528.2013. ...
McMahon and Block devised a model explaining these phenomena: light during the day does not have much of an effect on the ... McMahon has contributed several important discoveries to the field of chronobiology and vision. His research focuses on ... Block chronobiology Society for Neuroscience Vanderbilt University John E. Dowling "Douglas G. McMahon, Ph.D". vanderbilt.edu. ... marking an exciting time in the young field of chronobiology. McMahon contributed to the understanding of retinal ...
This phenomenon, called 'Spontaneous Internal Desynchrony', typically occurred in subjects after a duration of days to weeks. ... Rütger Wever was a German scientist, known for his significant contributions to the field of Chronobiology, including some of ...
Aside from human chronobiology, Roenneberg has significantly contributed to other aspects of the chronobiology field. He has ... He observed in the period of spore production (conidia bands) the phenomenon of masking, an unexpected effect on circadian ... Till Roenneberg (born May 4, 1953) is a professor of chronobiology at the Institute of Medical Psychology at Ludwig-Maximilian ... Kantermann, T; Roenneberg, T (2009). "Is light-at-night a health risk factor or a health risk predictor?". Chronobiology ...
In chronobiology, a circasemidian rhythm is a physiological arousal cycle that peaks twice in a 24-hour day. Numerous studies ... Eastman C. "Are separate temperature and activity oscillators necessary to explain the phenomena of human circadian rhythms?" ... Int J Chronobiology 2:175-180, 1974. - Kogi K, Ohta T. "Incidence of near accidental drowsing in locomotive driving during a ...
Its spatiotemporal variations lead to various measurable solar phenomena. Other solar phenomena are closely related to the ... The impact of the solar cycle on living organisms has been investigated (see chronobiology). Some researchers claim to have ... These eruptive phenomena can have a significant impact on Earth's upper atmosphere and space environment, and are the primary ... The magnetic polarity of sunspot pairs alternates every solar cycle, a phenomenon known as the Hale cycle. During the solar ...
It is a rare phenomenon for a self-funding scientist to form a bona fide IRO without traditional means of financial support. ... Chronobiology International. 24 (3): 521-537. doi:10.1080/07420520701420717. PMID 17612949. ...
Chronobiology Solar variation War cycles Revolutionary wave List of astronomical cycles Edward R. Dewey Nikolai Kondratiev ... having proved that the Sun's activity has an effect on many terrestrial phenomena. His works, mostly published in Russian, are ...
Chronobiology international 14 (5): 531-536 Solé, R., O. Miramontes y Goodwin BC. (1993) "Order and chaos in ant societies". J ... He suggested that nonlinear phenomena and the fundamental laws defining their behavior were essential to understand biology and ... 1997, "Temporal organization and disorganization in organisms". in: Chronobiology International 14 (5): 531-536 1997 Goodwin BC ... thus not taking into account dissipative effects that are required in a realistic approach to regulatory phenomena in biology. ...
Bünning received many honors in his life both in the field of chronobiology and botany. In 1960, he chaired in the 25th Cold ... This phenomenon, however, was not researched further until 1729 when Jean-Jacques d'Ortous de Mairan provided experimental data ... His 1958 work, "The Physiological Clock", was hailed as a milestone in the field of chronobiology, and his later works on plant ... Saunders, D (2005). "Erwin Bünning and Tony Lees, two giants of chronobiology, and the problem of time measurement in insect ...
Researchers in the field of chronobiology look for objective markers by which to measure the chronotype spectrum. Paine et al. ... referred to as the circadian system that regulate physiological phenomena (hormone levels, metabolic function, body temperature ... Chronobiology International, 31, 911-916. Giampietro, M.; Cavallera, G.M. (2006). "Morning and evening types and creative ...
Wiglusz, MS; Landowski, J; Cubała, WJ; Agius, M (September 2015). "Overlapping phenomena of bipolar disorder and epilepsy--a ... Chronobiology international. 28 (9): 825-33. doi:10.3109/07420528.2011.609951. PMID 22080789. McCarthy, MJ; Nievergelt, CM; ...
One example of this phenomenon is jetlag, in which traveling to another time zone causes desynchronization in sleep-wake cycles ... CHRONOBIOLOGY INTERNATIONAL, 17, 6, 719-732. Rutenfranz J, Helbruegge T. 1957. U ̈ ber Tageschwankungen der ... one of the founders of the field of chronobiology. His work demonstrated the existence of endogenous (internal) biological ...
Possible reasons it was not treated as a prevalent natural phenomenon include its abhorrence to people, the popular group and ... The proximate mechanism that allows for the correct timing of these periods involves circadian rhythms (see chronobiology), ...
The cell is also considered to be the basic unit in many pathological processes.[24] In addition, the phenomenon of energy flow ... Chronobiology - the study of periodic events in living systems. *Cognitive biology - the study of cognition ... Theoretical biology - the branch of biology that employs abstractions and mathematical models to explain biological phenomena ... Quantum biology - the study of the role of quantum phenomena in biological processes ...
Chronobiology Photosensitive ganglion cell Sense of time Retinohypothalamic tract Shift work sleep disorder Fahey, Jonathan ( ... which exhibit their own near-24-hour rhythms and control circadian phenomena in local tissue. The SCN receives input from ...
"complete field"), a phenomenon of visual perception Gestalt psychology (German spelling: Gestaltpsychologie), holistic ... chronobiology), external clue that helps to synchronize the internal body clock Zugunruhe (ornithology), pre-migration anxiety ... an alleged paranormal phenomenon where objects appear to move of their own accord Spiel, an attempt to present and explain a ...
Chronobiology International. 22 (3): 559-570. doi:10.1081/CBI-200062410. PMID 16076654.. ... phenomena. *Dream. *Exploding head syndrome. *False awakening. *Hypnagogia / Sleep onset. *Hypnic jerk ...
The phenomenon places great risk on the crew and passengers of an airplane because it significantly increases the chance of ... Chronobiology International. 25 (2-3): 373-388. doi:10.1080/07420520802118202. ISSN 0742-0528. ...
... collaborate closely with experimentalists in analyzing novel data and synthesizing new models of biological phenomena. ...
... study of phenomena Philately - study of postage stamps Philematology - act or study of kissing Phillumeny - collecting of ... political economy Chronobiology - study of biological rhythms Chrysology - study of precious metals Ciselure - art of chasing ... study of unexplained mental phenomena Parasitology - study of parasites Paroemiology - study of proverbs Parthenology - study ...
... of rhythmic temporal relationships in biological phenomena. Our bodies go through a day as if multiple clocks were hardwired ... DNC NEWS: Chronobiology and Chemotherapy: Subject: Administering cancer treatments according to circadian rhythms can increase ... There is a new buzzword in cancer therapy, Chronobiology. Simply put, this means the study of clocklike stuff in living things ... Chronobiology of the mammalian response to ionizing radiation. Potential applications in oncology. ...
6. Bechtel W. Circadian Rhythms and Mood Disorders: Are the Phenomena and Mechanisms Causally Related? Front Psychiatry 2015;6: ... Chronobiology is a field that studies the effects of time on biological systems. Periodicity is of particular interest. The ... Chronobiology is the study of biological rhythms. It examines the effects of time on biological events and internal biological ... Chronobiology is a continuously evolving field, and developments in this area can result in new implications for human health ...
Chronobiology is the study of timing mechanisms in biological systems as diverse as plants, animals and some micro-organisms. ... It includes rhythmic phenomena ranging from short period (ultradian) through daily (circadian) to long period (monthly, annual ...
Chronotype and time-of-day correlates of mind wandering and related phenomena. Biological Rhythm Research, 45(1), 37-49. https ... Chronobiology International, 17(6), 719-732. https://doi.org/10.1081/CBI-100102108.CrossRefPubMedGoogle Scholar ... mind-wandering is increasingly being recognized as a phenomenon that has so far evaded a one-to-one correspondence with any ... Chronobiology International, 34(7), 993-1001. https://doi.org/10.1080/07420528.2017.1308951.CrossRefPubMedGoogle Scholar ...
Chronobiology - field of biology that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar- ... Theoretical Biology - the mathematical modeling of biological phenomena. Zoology - study of animals, including classification, ...
Chronobiology is a field of science that examines periodic (cyclic) phenomena in living organisms. ... Views of a Foetus in the ... This phenomenon, known as "Mendels second law" or the "Law of independent assortment", means that the alleles of different ... Over many generations, the genomes of organisms can change, resulting in the phenomenon of evolution. Mutations and the ... In 1928, Frederick Griffith discovered of the phenomenon of transformation (see Griffiths experiment): dead bacteria could ...
Chronobiology is a field of biology that examines periodic (cyclic) phenomena in living organisms and their adaptation to solar ... "Father of Chronobiology" The University of Virginia offers an online tutorial on chronobiology. See the Science Museum of ... Chronobiology comes from the ancient Greek χρόνος (chrónos, meaning "time"), and biology, which pertains to the study, or ... Chronobiology is an interdisciplinary field of investigation. It interacts with medical and other research fields such as sleep ...
New models, such as the soliton model attempt to explain these phenomena, but are less developed than older models and have yet ... Also improbable possibility of modelling of local chronobiology mechanisms.. *Modern views regarding of the role of the ... The shortcomings of the model is its inability to reflect properly the following phenomena:. *The edge emphasizing property of ...
Chronobiology. WBLS19002. Temporal organisation; analysis of behavior; history and position of the field; circadian rhythms: ... phenomena and function; sleep wake regulation I & II; sleep and genetics; pathology of the circadian system; chronofarmacology ...
Charlotte Helfrich-Försters research activities focus on chronobiology, the study of periodic (cyclic) phenomena in living ...
The field of chronobiology has advanced greatly in recent decades, achieving important breakthroughs in research in nearly all ... A better understanding of periodicity of epileptic phenomena is very important for epilepsy chronotherapy. So far, only limited ... The use of epilepsy chronotherapy will be contingent upon the amount of knowledge generated from future epilepsy chronobiology ... Loddenkemper, T; Lockley, SW; Kaleyias, J; Kothare, SV Chronobiology of epilepsy: Diangnostic and Therapeutic Implications of ...
Darwinian biology describes phenomena that are a result of a myriad of interactions but have no particular dominant factor at ... When we have desynchronization of the SCN from the peripheral organ clocks, we call this a phase shift in chronobiology. This ... It is where QED and chronobiology collide primordially, and where a new paradigm can be born if we are perceiving what the ... What do I mean by that? Many physiologic phenomena we observe to occur cannot be explained by their theories, such as the ...
This may seem to be a heretical position to take, given that the phenomenon of food entrainment of circadian rhythms was first ... Standards of evidence in chronobiology: A response. Authors: Patrick M Fuller , Department of Neurology, Program in ... Mistlberger, RE Buijs, RM Challet, E Escobar, C Landry, GJ Kalsbeek, A et al. (2009). Standards of evidence in chronobiology: ... Fuller, P. M., Lu, J., & Saper, C. B. (2009). Standards of evidence in chronobiology: A response. Journal of Circadian Rhythms ...
Chronobiology: Sleep and synaptic rhythms. Chronobiologists at Ludwig-Maximilians-Universitaet (LMU) in Munich, Germany, show ... Researchers at the University of Liverpool have shown that the phenomenon of protein modification (phosphorylation) in cell ...
1974 Periodicity of infectivity of plasmodial gametocytes: the Hawking phenomenon. Int. J. Parasitol. 4, 103-106. doi:10.1016/ ... Chronobiology has historically been neglected by evolutionary ecologists, but this is changing as it offers a novel opportunity ... First, the majority of recent research in the field of chronobiology has focused on asking questions about clock mechanisms [7- ... Our study thus achieves a rare link between chronobiology and evolutionary biology, as well as representing a novel application ...
Dunlap J.C. J.J. Loros & P.J. DeCoursey (2004). Chronobiology. Biological timekeeping . Sunderland, ma: Sinauer Associates, Inc ... the phenomenon in which two or more independent rhythmic processes synchronize with each other - has been described in a wide ... One of the reasons that the actogram became a key representation in Chronobiology is that it allows a fast and reliable visual ... This effect in Chronobiology is called entrainment. Therefore, under entrained conditions, circadian rhythms adjust their ...
... science paid little attention to such phenomena for most of human history. In the 18th century, curious types such as Swedish ... The questions of chronobiology are as intricate and varied as the pieces of a clock - the gears, the springs, the screws - and ... One aim of chronobiology, aside from simply understanding the whys and wherefores of our inner clocks, is to find ways to ... Still, chronobiology didnt begin to be recognized as a legitimate field of scientific study until around the 1960s, with the ...
... difficulty of the causal process of such group phenomena. During the last World Congress on Chronobiology (Paris, September ... Astronomical contributions to the explanation of astrological phenomena -- Irina Predeanu. We discuss the possible contribution ... We observed that some solar phenomena also exhibit 27-to-28-day cycles similar to those of the Moon, indicating a further ... Hypotheses on the causal nature of astrological phenomena: 11.5 / 10.1 / 10.6 / 9.5 ...
en] Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Belgium/epidemiology ; Chronobiology Phenomena ; Female ; ...
When these phenomena are considered in accordance with human life cycles, the peaks of the cytokine secretions fall early in ... Attention to the control of clock genes and chronobiology is now increasing, and thus a proactive examination work in this ... A chronobiology research has been progressed with the elucidation of this circadian rhythm [1]. ... Akira Hashiramoto, Kohsuke Yoshida, Nao Shibanuma and Yoshitada Sakai (2018) Chronobiology of rheumatoid arthritis; now and ...
ZHANG S PHENOMENON (HIS ELECTROGRAM ALTERNANS) AND A NEW MODEL OF ATRIOVENTRICULAR NODE DUAL PATHWAY CONDUCTION Youhua Zhang, M ... Chronobiology is a branch of biomedical sciences devoted to the study of biological rhythms, that according to cycle length, ... EXERCISE RELATED HYPERTENSION (ERH) MAY NOT BE A BENIGN PHENOMENON Yzhar Charuzi, M.D., Cedars Sinai Medical Center, LA, USA ... TEMPORAL VARIATION IN ACUTE AORTIC DISEASES: ONLY A RANDOM PHENOMENON?. Roberto Manfredini, M.D., University of Ferrara, Italy ...
TEMPORAL VARIATION IN ACUTE AORTIC DISEASES: ONLY A RANDOM PHENOMENON?. Roberto Manfredini, M.D., University of Ferrara, Italy ... Chronobiology is a branch of biomedical sciences devoted to the study of biological rhythms, that according to cycle length, ... Endothelial hyperpermeability and vascular leakage are significant pathogenic phenomena. Although contributing to life- ...
CLPS1194: Sleep and Chronobiology Research. This course and the companion research apprenticeship provide students a fully ... Uses sleep as the focal point for describing complex behavioral phenomena. How is sleep measured and defined? How does sleep ... Epidemiology 274: Topics in Chronobiology Introduction to basic concepts and principles of circadian biology and how they ... Behavioral and neurobiological phenomena including sleep regulation sleep homeostasis, circadian rhythms, sleep disorders, ...
chronobiology 1. The scientific study of the effect of time on living systems. 2. That aspect of biology that is concerned with ... 3. The study of the causal relations between geographical phenomena occurring within a particular region.. 4. The study of the ... A branch of chronobiology concerned with the effects of drugs upon the timing of biological events and rhythms, and the ... the timing of biological events, especially repetitive or cyclic phenomena in individual organisms.. 3. The study of biological ...
Chronobiology Phenomena*. *Delayed-Action Preparations. *Drug Administration Schedule. *Epinephrine/administration & dosage. * ... Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications.. ...
  • Although humans have always been at least subliminally aware of how their own bodies and other life forms are affected by natural rhythms such as the day-night cycle, the seasons, and the tides, science paid little attention to such phenomena for most of human history. (medicalxpress.com)
  • This phenomenon, also known as jet syndrome, occurs when humans are transported by jet plane across time zones. (thefreedictionary.com)
  • Humans similarly transported over great distances often experience fatigue and lowered efficiency for several days, a phenomenon known as "jet lag," or jet syndrome . (britannica.com)
  • Based on a series of studies on the prevalence of social jet lag and the toll it can take, researchers at the Centre of Chronobiology, Ludwig Maximilian University of Munich, recently suggested "that work (and school) schedules should be adapted to chronotype [a person's preferred timing for sleep and activity] whenever possible. (promises.com)
  • Uses sleep as the focal point for describing complex behavioral phenomena. (sleepresearchsociety.org)
  • We describe potential neurobiological constructs that can explain this phenomenon: during light anesthesia the subcortical mechanisms subserving spontaneous behavioral responsiveness are disabled but information integration within the corticothalamic network continues to produce consciousness, and unperturbed norepinephrinergic signaling maintains connectedness. (blogspot.com)
  • When these phenomena are considered in accordance with human life cycles, the peaks of the cytokine secretions fall early in the morning after the melatonin blood concentration peaks in human bodies. (oatext.com)
  • We observed that some solar phenomena also exhibit 27-to-28-day cycles similar to those of the Moon, indicating a further possible impact of the Sun on cycles of the biological menses. (aureas.org)
  • The basic idea in Biosyntonic therapy is replacing needles with ceramics, while respecting and synchronizing the chronobiology and the variable electromagnetic potential created by the natural cycles of the body. (mastersandmillionaires.com)
  • There are different mechanisms that arrange the order of chemical reactions depending on the need for their products: biochemical pacemakers as investigated in chronobiology, separation of reactions or charges by space and external pacemakers such as light and temperature. (beilstein-institut.de)
  • We found that a moderate dose of alcohol consumed by a young woman an hour before bed is associated with increased sleep intensity in the first couple hours of the sleep episode," says author Mary A. Carskadon, PhD, with the Bradley Hospital Sleep and Chronobiology Laboratory and Brown Medical School. (scienceblog.com)
  • Researchers at the University of Liverpool have shown that the phenomenon of protein modification (phosphorylation) in cell signalling is far more diverse and complex than previously thought. (brightsurf.com)
  • According to Harvard Medical School researchers, "As people age, it takes longer to fall asleep, a phenomenon called increased sleep latency. (amazonaws.com)
  • Others who have contributed significantly to chronobiology in the 20th century include A. Jores (Federal Republic of Germany), J. Möllerstrom and E. Forsgren (Sweden), J. W. Hastings and F. A. Brown (United States), and J. Cloudsley-Thompson and J. E. Harker (Great Britain). (thefreedictionary.com)
  • Harnessing these important biological phenomena to match metabolic supply to demand and bolster cell defenses at the apposite time may be a future therapeutic strategy in the intensive care unit. (eur.nl)
  • Eating three meals a day with snacks in-between or eating at any time are recent phenomenon in our modern societies . (naturalmedicineweek.com.au)
  • Extreme examples of this phenomena are people who work in front of computer monitors every day for years, and thus, are exposed to very intense electromagnetic pollution and often suffer severe health problems, also people who live under high power lines for long periods of time frequently develop cancer. (mastersandmillionaires.com)
  • For chronobiology, birds are particularly interesting subjects because their outstanding mobility implies a need for sophisticated and robust internal time-keeping, for example during long-distance migration to remote target areas. (gla.ac.uk)
  • The persistent rhythms of life, the body clocks that control when you wake, sleep, eat, digest food, and perform nearly every other function of a living organism, are all the province of chronobiology. (medicalxpress.com)
  • Using 400 ambulatory BP recordings over 8 weeks composed of 35 302 measurements, the trended cosinor model was found to be the best descriptor of BP chronobiology. (biomedsearch.com)
  • This publication provides in a concise yet accomplished model the fundamental ideas of chronobiology and their software to medical medication. (tvcirculando.com.br)
  • 2. The other thing you cannot afford to do is evaluate whether or not a technique is having an effect based upon having (or not having) any of those superficial, irrelevant, distracting phenomena discussed above, like face flushing, seeing light swirls, having sensations of this, that or the other thing, etc. (brainwaveentrainmentgurus1a.com)