Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
Disruptions of the rhythmic cycle of bodily functions or activities.
A multidisciplinary field of research and practice studying the periodicity of biological systems and the application of principles of chronobiology to various therapeutic strategies. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.
The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Organized activities related to the storage, location, search, and retrieval of information.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
Surgical procedure to remove one or both breasts.
Pain in the breast generally classified as cyclical (associated with menstrual periods), or noncyclical, i.e. originating from the breast or nearby muscles or joints, ranging from minor discomfort to severely incapacitating.
Surgery restricted to the management of minor problems and injuries; surgical procedures of relatively slight extent and not in itself hazardous to life. (Dorland, 28th ed & Stedman, 25th ed)
The measurement and recording of MOTOR ACTIVITY to assess rest/activity cycles.
Tumors or cancer of the human BREAST.
Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
The study of speech or language disorders and their diagnosis and correction.
A characteristic symptom complex.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.
Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)
A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)
Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.
A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)
Persistent flexure or contracture of a joint.
A group of muscle diseases associated with abnormal mitochondria function.
Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Inorganic compounds that contain lithium as an integral part of the molecule.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Agents that are used to treat bipolar disorders or mania associated with other affective disorders.
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
A plant genus of the family FAGACEAE that is a source of TANNINS. Do not confuse with Holly (ILEX).

Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work. (1/96)

We tested the hypothesis that circadian adaptation to night work is best achieved by combining bright light during the night shift and scheduled sleep in darkness. Fifty-four subjects participated in a shift work simulation of 4 day and 3 night shifts followed by a 38-h constant routine (CR). Subjects received 2,500 lux (Bright Light) or 150 lux (Room Light) during night shifts and were scheduled to sleep (at home in darkened bedrooms) from 0800 to 1600 (Fixed Sleep) or ad libitum (Free Sleep). Dim light melatonin onset (DLMO) was measured before and after the night shifts. Both Fixed Sleep and Bright Light conditions significantly phase delayed DLMO. Treatments combined additively, with light leading to larger phase shifts. Free Sleep subjects who spontaneously adopted consistent sleep schedules adapted better than those who did not. Neither properly timed bright light nor fixed sleep schedules were consistently sufficient to shift the melatonin rhythm completely into the sleep episode. Scheduling of sleep/darkness should play a major role in prescriptions for overcoming shift work-related phase misalignment.  (+info)

beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome. (2/96)

Smith-Magenis syndrome (SMS) is a clinically recognisable contiguous gene syndrome ascribed to interstitial deletions of chromosome 17p11.2. Patients have a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Serum melatonin levels and day-night behaviour were studied in nine SMS children (aged 4 to 17 years) given acebutolol, a selective beta(1)-adrenergic antagonist (10 mg/kg early in the morning). Cardiac examination, serum melatonin, motor activity recordings, and sleep diaries were monitored before and after drug administration. The present study shows that a single morning dose of acebutolol suppressed the inappropriate secretion of melatonin in SMS. A significant improvement of inappropriate behaviour with increased concentration, delayed sleep onset, increased hours of sleep, and delayed waking were also noted. These results suggest that beta(1)-adrenergic antagonists help to manage hyperactivity, enhance cognitive performance, and reduce sleep disorders in SMS.  (+info)

Hypothalamic involvement in chronic migraine. (3/96)

OBJECTIVES: Chronic migraine (CM), previously called transformed migraine, is a frequent headache disorder that affects 2%-3% of the general population. Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM. Hypothalamic dysfunction has been implicated in its pathogenesis, but it has never been studied in patients with CM. The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion. METHODS: A total of 338 blood samples (13/patient) from 17 patients with CM and nine age and sex matched healthy volunteers were taken. Melatonin, prolactin, growth hormone, and cortisol concentrations were determined every hour for 12 hours. The presence of comorbid disorders was also evaluated. RESULTS: An abnormal pattern of hypothalamic hormonal secretion was found in CM. This included: (1) a decreased nocturnal prolactin peak, (2) increased cortisol concentrations, (3) a delayed nocturnal melatonin peak in patients with CM, and (4) lower melatonin concentrations in patients with CM with insomnia. Growth hormone secretion did not differ from controls. CONCLUSION: These results support hypothalamic involvement in CM, shown by a chronobiologic dysregulation, and a possible hyperdopaminergic state in patients with CM. Insomnia might be an important variable in the study findings.  (+info)

Heart rate and energy expenditure of incubating wandering albatrosses: basal levels, natural variation, and the effects of human disturbance. (4/96)

We studied the changes in heart rate (HR) associated with metabolic rate of incubating and resting adult wandering albatrosses (Diomedea exulans) on the Crozet Islands. Metabolic rates of resting albatrosses fitted with external HR recorders were measured in a metabolic chamber to calibrate the relationship between HR and oxygen consumption (V(O(2))) (V(O(2))=0.074 x HR+0.019, r(2)=0.567, P<0.001, where V(O(2)) is in ml kg(-1) min(-1) and HR is in beats min(-1)). Incubating albatrosses were then fitted with HR recorders to estimate energy expenditure of albatrosses within natural field conditions. We also examined the natural variation in HR and the effects of human disturbance on nesting birds by monitoring the changes in HR. Basal HR was positively related to the mass of the individual. The HR of incubating birds corresponded to a metabolic rate that was 1.5-fold (males) and 1.8-fold (females) lower than basal metabolic rate (BMR) measured in this and a previous study. The difference was probably attributable to birds being stressed while they were held in the metabolic chamber or wearing a mask. Thus, previous measurements of metabolic rate under basal conditions or for incubating wandering albatrosses are likely to be overestimates. Combining the relationship between HR and metabolic rate for both sexes, we estimate that wandering albatrosses expend 147 kJ kg(-1) day(-1) to incubate their eggs. In addition, the cost of incubation was assumed to vary because (i) HR was higher during the day than at night, and (ii) there was an effect of wind chill (<0 degrees C) on basal HR. The presence of humans in the vicinity of the nest or after a band control was shown to increase HR for extended periods (2-3 h), suggesting that energy expenditure was increased as a result of the disturbance. Lastly, males and females reacted differently to handling in terms of HR response: males reacted more strongly than females before handling, whereas females took longer to recover after being handled.  (+info)

Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. (5/96)

Mammalian free-running circadian rhythms are entrained to the external light/dark cycle by photic signaling to the suprachiasmatic nuclei via the retinohypothalamic tract (RHT). We investigated the circadian entrainment and clock properties of math5-/- mutant mice. math5 is a critical regulator of retinal ganglion cell development; math5-/- mice show severe optic nerve hypoplasia. By anterograde cholera toxin B tracing, we find that math5-/- mice do not develop an identifiable RHT pathway. This appears to be attributable to agenesis or dysgenesis of the majority of RHT-projecting retinal ganglion cells. math5-/- mice display free-running circadian rhythms with a period approximately 1 hr longer than B6/129 controls (24.43 +/- 0.10 vs 23.62 +/- 0.19 hr; p < 0.00001). The free-running period of heterozygote mice is indistinguishable from that of controls. math5-/- mice show no entrainment to light/dark cycles, whereas heterozygote mice show normal entrainment to both 12 hr light/dark cycles and to a 1 hr skeletal photoperiod. math5-/- mice show reduced ability to entrain their rhythms to the nonphotic time cue of restricted running wheel access but demonstrate both free-running behavior and entrained anticipation of wheel unlocking in these conditions, suggesting the presence of a second diurnal oscillatory system in math5-/- animals. These results demonstrate that retinal ganglion cell input is not necessary for the development of a free-running circadian timekeeping system in the suprachiasmatic nucleus but is important for both photic entrainment and determination of the free-running period.  (+info)

Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo. (6/96)

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse prognosis in cardiovascular diseases. We examined potential alterations in BPV and HRV in genetically dyslipidemic, apolipoprotein (apo) E-/-, and control mice and the effect of chronic statin treatment on these parameters in relation to their NO synthase (NOS)-modifying properties. METHODS AND RESULTS: BP and HR were recorded in unrestrained, nonanesthetized mice with implanted telemetry devices with or without rosuvastatin. Cardiac and aortic expression of endothelial NOS and caveolin-1 were measured by immunoblotting. Both systolic BP and HR were elevated in apoE-/- mice, with abolition of their circadian cycles. Spectral analysis showed an increase in their systolic BPV in the very-low-frequency (+17%) band and a decrease in HRV in the high-frequency (-57%) band, reflecting neurohumoral and autonomic dysfunction. Decreased sensitivity to acute injection of atropine or an NOS inhibitor indicated basal alterations in both parasympathetic and NOS regulatory systems in apoE-/- mice. Aortic caveolin-1 protein, an inhibitor of endothelial NOS, was also increased in these mice by 2.0-fold and correlated positively with systolic BPV in the very-low-frequency band. Rosuvastatin treatment corrected the hemodynamic and caveolin-1 expression changes despite persisting elevated plasma cholesterol levels. CONCLUSIONS: Rosuvastatin decreases caveolin-1 expression and promotes NOS function in apoE-/-, dyslipidemic mice in vivo, with concurrent improvements in BPV and HRV. This highlights the beneficial effects of rosuvastatin on cardiovascular function beyond those attributed to lipid lowering.  (+info)

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. (7/96)

The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle disrupts the synchronous oscillation of circadian components in the rat SCN. The phases of the RNA cycles of the period genes Per1 and Per2 and the cryptochrome gene Cry1 shifted rapidly in the ventrolateral, photoreceptive region of the SCN, but were relatively slow to shift in the dorsomedial region. During the period of desynchrony, the animals displayed increased nighttime rest, the timing of which was inversely correlated with the expression of Per1 mRNA in the dorsomedial SCN. Molecular resynchrony required approximately 6 d after a 10 hr delay and 9 approximately 13 d after a 6 hr advance of the LD cycle and was accompanied by the reemergence of normal rest-activity patterns. This dissociation and slow resynchronization of endogenous oscillators within the SCN after an LD cycle shift suggests a mechanism for the physiological symptoms that constitute jet lag.  (+info)

Loss of circadian rhythm of blood pressure following acute stroke. (8/96)

BACKGROUND: Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator in patients with stroke in all communities. The risk of stroke is directly related to elevations of blood pressure. A number of clinical studies have shown that the control of hypertension leads to a reduction in the incidence of stroke in a community. However there is still considerable controversy surrounds the changes in blood pressure in various subtypes of strokes and problem of management of elevated BP after stroke. We studied the circadian rhythm of blood pressure in patients following acute stroke. METHODS: To study the circadian rhythm of blood pressure, fifty consecutive patients with an acute stroke who were admitted to medical emergency within 120 hours of onset were included in the study. After a detailed history and clinical examination, a continuous blood pressure monitor (Spacelab 90207) was attached on the side ipsilateral to intracranial lesion (unaffected arm). The blood pressure was recorded for 24 hours at 15 minutes interval during daytime (6.00 am-6.00 pm) and 20 minutes interval overnight (6 pm to 6 am). RESULTS: Risk factors for stroke in 50 patients included hypertension in 31(62%), diabetes mellitus in 4 (8%), smoking in 13 (26%) and previous history of transient ischemic attack in 7 (14%) patients. Mean systolic pressure and diastolic pressure at admission were higher in patients with hemorrhagic stroke -29 patients (177 +/- 24 mmHg and 105 +/- 19 mmHg respectively) compared to patients with ischemic strokes-21 patients (150 +/- 36 mm Hg and 89 +/- 18 mm Hg respectively, p value <0.01 in both comparisons). The normal diurnal variation in blood pressure (night time dipping of more than 10%) was abolished in 44 (88%) of patients. Out of 44 nondippers, 29 patients showed reverse dipping i.e. rise of BP during night time compared to day time levels. None of the risk factors, clinical or laboratory variables, type of stroke or blood pressure changes differed significantly between these two groups. CONCLUSIONS: Therefore, we showed a pathologically reduced or abolished circadian BP variation after stroke. Absence of normal dipping results in a higher 24 hour blood pressure load and may have more target organ damage than those with normal diurnal variation of blood pressure.  (+info)

Within the Life Safety Code, the NFPAs requirements for emergency lighting are referenced under section 7.9. Emergency illumination (when required) must be provided for a minimum of 1.5-hours in the event of failure of normal lighting. The emergency lighting must be arranged to provide initial illumination of not less than an average of one foot-candle and a minimum at any point of 0.1-foot-candle measured along the path of egress at floor level. And the emergency lighting system must be arranged to provide illumination automatically in the event of any interruption of normal lighting (section 7.9.2.3). ...
Although sleep and circadian rhythm disturbances are significant features of bipolar disorder and are associated with illness severity and recurrence, less is known about their significance prior to illness onset. Therefore, this study investigated these variables using objective assessment methods within a sample at high-risk of bipolar spectrum disorders. Thirty-one high-risk and 24 age- and gender-matched control participants wore an actigraph for 7 days to obtain sleep and circadian activity data. Self-report measures of mood, bed and get-up times, and cognitive style were also obtained. High-risk participants exhibited greater variability in duration, fragmentation, and efficiency of sleep, shorter sleep duration, and later and more variable bedtimes than controls. They also had lower relative amplitude of activity patterns and made more positive self-appraisals for hypomanic experiences. Logistic regression showed that positive self-appraisal and variability in bedtime significantly ...
Non-24-hour sleep-wake syndrome, also called free-running type or non-24-hour circadian rhythm disorder, is one of many circadian rhythm disorders.
Principal Investigator:UCHIYAMA Makoto, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Psychiatric science
Muming Poo, director of the Institute of Neuroscience of Chinese Academy of Sciences, introduces the significance of the cloned monkey models with circadian rhythm disorders at a press conference in Shanghai, east China, Jan. 23, 2019. China has cloned five monkeys from a gene-edited macaque with circadian rhythm disorders, the first time multiple monkeys have been cloned from a gene-edited monkey for biomedical research. Scientists made the announcement Thursday, with two articles published in National Science Review, a top Chinese journal in English. The cloned monkeys were born in Shanghai at Institute of Neuroscience of Chinese Academy of Sciences. (Xinhua/Jin Liwang). ...
Kirsten ten Tusscher first of all made a model that described the electrical behaviour of individual human heart muscle cells. She demonstrated that the behaviour of this model corresponded well with results from experiments on human heart cells. The source code of this cell model is freely available on Internet.. The researcher then used her new model to simulate the behaviour of 13,5 million individual grid points, which together form the anatomy of a human heart. As the model is extremely large and requires a considerable amount of calculating power, she used the TERAS supercomputer of SARA Computing and Networking Services and a mini-Beowulf cluster in her own Department of Theoretical Biology at Utrecht University. With this she studied the behaviour of electrical wave patterns during certain rhythm disorders in the human heart.. Heart rhythm disorders are abnormalities in the timing, sequence and co-ordination of how the heart muscle contracts. These vary in seriousness from palpitations ...
Clinical Presentation. The clinical presentation varies between patients and conditions, ranging from no symptoms to severe and frequently occurring symptoms 10. Though palpitations may occur infrequently, the typical symptoms are syncope (fainting) and cardiac arrest. Most inherited heart rhythm disorders are caused by autosomal dominant mutations 11-13. This means that a single genetic defect is present that results in the clinical condition that is inherited or transmitted to 50% of offspring. Typically, an index case (termed proband) presents with fainting, cardiac arrest or sudden death, and family screening identifies other members that are affected but with little or no symptoms. Being genetically affected, however, does not necessarily mean that individuals will be symptomatic. Penetrance is the term used to describe the proportion of individuals who possess the genetic mutation and are also symptomatic. The penetrance of inherited heart rhythm disorders is variable, ranging from 20-60% ...
How to Treat Heart Rhythm Disorders with Exercise. If you find out that you have a heart rhythm disorder, also known as an arrhythmia, it does not mean that you can never exercise again.http://www.heart.org/HEARTORG/Conditions/Arrhythmia...
There are eight reversible factors that can cause depression.. For some, depression may result from a combination of genetics, circadian rhythm disturbances, upbringing and social factors.. For others, depression may be rooted in a lack of dietary omega-3 fats combined with harmful addictions and adverse frontal lobe factors.. Exercise, herbs and nutrition play a role in the brains ability to manufacture serotonin and other neurotransmitters; thus, one may be able to manage good and bad stress, improve mood and change ones attitude and actions.. Dr. Neil Nedley, internal medicine specialist in cardiology, gastroenterology, and mental health and lifestyle medicine, has put together a DVD and eight-week depression recovery program.. This is being offered to Campbell River as a community service by Family Health and Education.. There are two free introductory sessions at 7 p.m. on Tues. Oct. 4 and Tues. Oct. 11. The eight-week program happens every Tuesday from 7-9 p.m. from Oct. 18 --Dec. 6, ...
The open and flexible UltraGATEWAY allows NightShift to build the routing and configuration of the data directly into their reporting and administration system. This makes it seamless to administer a scalable and growing radiology network, allowing simple modification and additions of doctors, customer sites and data centers in a constantly demanding environment. This partnership helps UltraRAD provide a better workflow driven solution for its customers and build a solid infrastructure for Nightshift ...
VELscope System uses blue spectrum lighting to screen for oral cancer. The VELscope® Oral Assessment System centers on a handheld scope that we use to screen for oral tissue abnormalities, including cancer. Unlike other adjunctive devices used for oral screening, the VELscope® does not require any dyes or prolonged testing procedures. In fact, a VELscope® exam is performed in our office during a routine hygiene exam (and under normal lighting conditions) in about two minutes. VELscope® technology is changing the way oral cancer screenings take place. The VELscope® handheld device emits a harmless, bright blue light which is used to inspect the mouth and tongue. The device is extremely sensitive to abnormal tissue changes and the distinctive blue-spectrum light causes the soft tissues of the mouth to naturally fluoresce. Healthy tissues fluoresce in distinct patterns that are visibly disrupted by trauma or disease, such as neoplastic lesions, and fungal, viral or bacterial infections. We use ...
The usefulness of QLF™ for the normal clinical practice lies, for some people, primarily in the realm of prevention and patient communication. Below an example of the use of QLF™ for the detection of cracks that are pretty hard, if not impossible, to detect with the naked eye under normal lighting conditions. See the QLF Library under Cracks. ...
iltered, temperature-controlled units with a 12 h light/dark cycle with free access to food and water. Animals were monitored for signs of distress 9128839
Healthy people with Aβ buildup have irregular circadian rhythms. In mice, circadian disruptions dull daily Aβ oscillations and lead to more plaques.. ...
Healthy people with Aβ buildup have irregular circadian rhythms. In mice, circadian disruptions dull daily Aβ oscillations and lead to more plaques.. ...
When the human brain takes on intellectually challenging tasks, groups of neurons tune in to one another for a fraction of a second and harmonise, then go back to improvising, says a new study.
The underlying cause of any heart rhythm disorder provides the basis for selecting the best treatment plan. In general, the best treatment is the least invasive option that effectively controls the heart rhythm disorder. Treatment options fall into several categories from the least to the most invasive.
A method for quantifying cardiac desynchrony of the right and left ventricles includes obtaining cardiac acquisition data from a medical imaging system, and determining a movement profile from the cardiac acquisition data. The movement profile is directed toward identifying at least one of a time-based contraction parameter for a region of the left ventricle (LV), and a displacement-based contraction parameter for a region of the LV. The determined movement profile is visually displayed by generating a 3D model therefrom.
Buy Cordarone Online! Cordarone is used to treat a variety of different types of fast, abnormal heart rhythms (these are known as tachyarrhythmias). It is used for severe rhythm disorders when other treatments are not effective or cannot be used.
Buy Cordarone Online! Cordarone is used to treat a variety of different types of fast, abnormal heart rhythms (these are known as tachyarrhythmias). It is used for severe rhythm disorders when other treatments are not effective or cannot be used.
The human body functions according to a circadian rhythm thought to be controlled by a biological clock located in the part of the brain called the hypothalamus. There are several distinct disorders of our circadian rhythm and these are listed below: ...
The University Health Network (UHN) is excited to be hosting the 2018 Traumatic Brain Injury Conference an annual, one day event for healthcare practitioners, students, researchers, and community members who encounter traumatic brain injury in their practice. This event will explore topics such as concussion, long-term effects of brain injury, rehabilitation, and sleep/wake disturbances following brain injury from prominent researchers and renowned scholars.. February 2, 2018 ...
The University Health Network (UHN) is excited to be hosting the 2018 Traumatic Brain Injury Conference an annual, one day event for healthcare practitioners, students, researchers, and community members who encounter traumatic brain injury in their practice. This event will explore topics such as concussion, long-term effects of brain injury, rehabilitation, and sleep/wake disturbances following brain injury from prominent researchers and renowned scholars.. February 2, 2018 ...
TY - JOUR. T1 - An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression. AU - Akiyama, Tokiho. AU - Katsumura, Takafumi. AU - Nakagome, Shigeki. AU - Lee, Sang Il. AU - Joh, Keiichiro. AU - Soejima, Hidenobu. AU - Fujimoto, Kazuma. AU - Kimura, Ryosuke. AU - Ishida, Hajime. AU - Hanihara, Tsunehiko. AU - Yasukouchi, Akira. AU - Satta, Yoko. AU - Higuchi, Shigekazu. AU - Oota, Hiroki. PY - 2017/6. Y1 - 2017/6. N2 - Humans show various responses to the environmental stimulus in individual levels as physiological variations. However, it has been unclear if these are caused by genetic variations. In this study, we examined the association between the physiological variation of response to light-stimulus and genetic polymorphisms. We collected physiological data from 43 subjects, including light-induced melatonin suppression, and performed haplotype analyses on the clock genes, PER2 and PER3, exhibiting geographical differentiation ...
Bright light therapy Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia Psychiatry Clin Neurosci 2000, 54, 352-3 Effects of phototherapy in patients with delayed sleep phase syndrome * Psychiatry Clin Neurosci 1999 Apr;53(2):231-3 Melatonin suppression by illumination of upper and lower visual fields * J Biol Rhythms. 1999 Apr;14(2):122-5…
history or DSISD (Duke Insomnia Sleep Diagnostics) suggests sleep disorder other than insomnia (e.g., sleep apnea, narcolepsy, periodic leg movements, etc.), or have insomnia associated with circadian rhythm disturbances, such as night or rotating shift work or travel across more than four time zones in the 14 days before Initial Screening (Visit 1) or during the study ...
Statement of Need Recent catastrophic bus and train accidents in the Bronx, New York, have highlighted the importance of understanding the negative effects of circadian sleep-wake disruption in shift workers, especially those in positions of responsibility for public safety, including bus and train operators and healthcare workers. Scientific evidence exists that manipulations by employers and employees can reduce the risk of errors due to sleep deprivation, so long as there is an understanding of underlying chronobiologic principles and the corresponding therapeutic options that can reduce and improve circadian disruption.. Activity Goal This program is designed to present the current understanding of chronobiology and the effects upon health and disease and to highlight the importance of circadian disruption on shift workers performances and productivity. Appropriate interventions can be undertaken by employers and employees to mitigate the effects of circadian disruption by manipulating ...
Introduction: Shift work, characterized by irregular schedules resulting in sleep loss and misalignment of circadian rhythms, is associated with increased incidence of cardiovascular disease. We tested whether circadian misalignment has an adverse impact on cardiovascular function independently of sleep loss. Methods: 19 healthy adults were studied using a parallel group design comparing two inter
Sleep duration and disruption have a significant impact on human health, quality of life, and life expectancy. Among humans, it is clear that the biological need for sleep varies dramatically. Natural short sleepers have a lifelong tendency to sleep only 4-5 h per night and to awaken refreshed and energetic. Natural long sleepers biologically require 9-10 h/night to feel well rested. The reason for these physiological differences is unknown and the genetic basis has not been explored.. Although relatively little is known regarding the genetic basis of sleep, there is a wealth of information on the genetics of circadian clock function across species. Sleep and circadian function are distinct processes that interact in living organisms. Although these two systems can operate independently, recent studies indicate a more intimate relationship.. Over the last decade, genetic material has been collected from individuals and families with circadian rhythm disturbances including familial advanced sleep ...
WASHINGTON - According to a new survey issued by the Heart Rhythm Society, the majority of Americans are unaware of two serious and potentially life-threatening heart rhythm disorders, atrial fibrillation (AF) and sudden cardiac arrest (SCA). In fact, only one in three Americans have ever heard of AF or recognize the number of lives claimed each year from SCA. Throughout February, Heart Health Month, the Heart Rhythm Society spotlights the need for public education on heart rhythm disorders affecting millions of people, and the specialists best suited to treat them - electrophysiologists.. More than 250,000 deaths occur each year as a result of SCA, more than breast cancer, lung cancer or AIDs. Yet, according to the recent survey, more than 65 percent of Americans not only underestimate the seriousness of SCA, but also believe SCA is a type of heart attack. While this current data does show a 5 percent increase since the Societys 2008 SCA awareness survey, the lack of awareness remains high and ...
Circadian clocks are found in nearly all organisms, from bacteria to mammals, and ensure that behavioral and physiological processes occur at optimal times of day and in the correct temporal order. It is becoming increasingly clear that chronic circadian misalignment (CCM), such as occurs in shift workers or as a result of aberrant sleeping and eating schedules common to modern society, has profound metabolic and cognitive consequences, but the proximate mechanisms connecting CCM with reduced organismal health are unknown. Furthermore, it has been difficult to disentangle whether the health effects are directly induced by misalignment or are secondary to the alterations in sleep and activity levels that commonly occur with CCM. Here, we investigated the consequences of CCM in the powerful model system of the fruit fly, Drosophila melanogaster. We subjected flies to daily 4-h phase delays in the light-dark schedule and used the Drosophila Activity Monitoring (DAM) system to continuously track locomotor
Behavioural signs and symptoms in dementia are of central clinical significance. There are a number of standardised rating scales available for the assessment of motor phenomena in dementia. However, there is no objective method of assessing these symptoms. In addition, the reliability of these scales, especially when used by caregivers from within families, has been questioned. In order to overcome this flaw, we propose the use of an actometric device for assessing behaviour motor symptoms in dementia. In the first part of this dissertation we assessed the reliability and the concurrent validity of an actometric device against two behavioural scales. Results show satisfactory validity and good reliability of this method. In the second part of this dissertation, we reanalysed data from our validation study, investigating whether the pattern of circadian rhythm disturbances is different in patients suffering from Alzheimer disease and patients suffering from vascular dementia, controlling ...
Causes of Arrhythmias (Heart Rhythm Disturbances) can depend on each individual situation. Learn about causes of Arrhythmias (Heart Rhythm Disturbances) and find symptoms, diagnosis, and many types of smart treatments for Arrhythmias (Heart Rhythm Disturbances) at FoundHealth.
FECYT - Spanish Foundation for Science and Technology. A possible pharmacology objective for chemotherapy. Patients receiving chemical treatment for cancer often suffer fatigue and body weight loss, two of the most worrying effects of this therapy linked to the alteration of their circadian rhythms.. The circadian system, better known as our biological clock, is responsible for coordinating all the processes that take place in our organism.. If it does not function correctly, what is known as a circadian disruption or chronodisruption, has for years been linked to an increased incidence of cancer, obesity, diabetes, depression, cognitive problems or cardiovascular diseases.. Also, circadian disruption in cancer patients aggravates the prognosis of the disease and the chance of survival for these patients diminishes, Elisabet Ortiz Tudela, a researcher at the University of Murcia, told SINC.. The expert is the author of a study published in the International Journal of Cancer, which reveals ...
Heart rhythm disorders or heart rhythm disorders heart rhythm is irregular, sometimes fast (tachycardia) or slow or irregular (arrhythmia). At the heart rhythm disorder symptoms are generally mild without symptoms, so interference can only be known if you are feeling the pulse of the chest or the baby and found the irregular rhythm until hard to count how many times per minute her.. If this is the case does not mean there is no problem, precisely you should take him to the doctor to check and make sure his condition. As a precaution, you could be asked for recording an electrocardiogram (ECG) is used to determine the condition of his heart.. From the ECG recording, you can find out the childs heart condition in a normal state or there is interference. In severe heart rhythm disorders, the symptoms are a decrease in blood pressure, resulting in a pale, cold sweat and the body feels cold. Worse could seizures unconscious.. ...
Abstract:. BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P,0.03) than in the control group. No significant association was ...
obesity and mental illness. However, circadian disruptions are becoming increasingly widespread in our modern world. As such, there is an urgent need for novel technological solutions to address these issues.. In this talk, I will introduce the notion of Circadian Computing - technologies that support our innate biological rhythms. Specifically, I will describe a number of my recent projects in this area. First, I will present novel sensing and data-driven methods that can be used to assess sleep and related circadian disruptions. Next, I will explain how we can model and predict alertness, a key circadian process for cognitive performance. Third, I will describe a smartphone based tool for maintaining circadian stability in patients with bipolar disorder. To conclude, I will discuss a vision for how Circadian Computing can radically transform healthcare, including by augmenting performance, enabling preemptive care for mental health patients, and complementing current precision medicine ...
Sleep refreshes and restores us. However, when sleep is disrupted it can result in behavioral as well as physical problems that can seriously impact the ability of a child to perform optimally in school. This talk will provide participants with an overview of sleep and the problems that are associated with it. The highlights will include a number of the more common disturbances of sleep such as bedtime difficulties, night waking, circadian rhythm disorders and sleep terrors, and recent work on the nonmedical treatments for these problems. Described will be our work with children who have autism spectrum disorder who pose unique challenges and who exhibit a higher prevalence of sleep problems compared to the general population.. Review V. Mark Durands biographical statement.. ...
Generation of Knockout Mice. The methods for generation of the knockout mice were as described in detail by Roberts et al. (2000). In brief, gene inactivation was obtained by disruption of the first coding exon of the μ-opioid receptor gene in 129/SV embryonic stem cells. Germline transmission occurred from the breeding of chimeric males with C57BL/6Orl females. After mice were genotyped, those showing germline transmission were used as founder animals to produce the F1 animals used in these experiments. We used male homozygous MOR KO and WT littermate mice (shipped from Scripps Research Institute, La Jolla, CA) in these experiments. The genetic background of these mice was a hybrid C57BL/6Orl × 129/SV strain. We housed mice one to three per cage in a temperature-controlled room in which the lights were on a 12-h light/dark cycle with lights off at 10:00 AM.. In Vitro Single-Cell Recordings. We used 4- to 5-month-old MOR KO and genetically intact WT littermate mice in this study. In some ...
Background Maternal alcohol consumption is known to adversely affect fetal neurodevelopment. Cages and bedding, including access to environmental enrichment, were standardized between cages. Colonies were kept inside a controlled environment on a 14/10-h light/dark cycle at a heat of 21C to 24C with 40% to 60% moisture. Female mice of approximately 8 weeks of age were time-mated immediately with 8- to 12-week aged males. During gestation, dams were housed separately in standard cages. Six treatment occasions were selected to approximate ethanol publicity occurring in MK-0974 manufacture the human being 1st, second, and third trimesters: dam treatment at embryonic days (E) 8 and 11 (human being trimester one equivalent), E14 and 16 MK-0974 manufacture (human being second trimester equivalent), and pup treatment on postnatal days (P) 4 and 7 (human being third trimester equivalent) [19,25]. Each mouse (dam or pup) was treated on two treatment. To model punctuated high-blood alcohol (binge-like) ...
Induction of Diabetes. All procedures used in this study were approved by the animal care and use committee at Southern Illinois University, School of Medicine, and conformed according to National Institutes of Health and institutional guidelines. Mice were housed in standard cages and maintained on a 12-h light/dark cycle at an ambient temperature of 22 ± 1°C. Mice were housed in specific pathogen-free barrier animal facility, and rodent laboratory chow (Laboratory Diet 5001; Nutrition International, Inc., Brentwood, MO) and drinking water were provided ad libitum. Mice were at least 6 to 10 weeks of age and weighed between 18 and 23 g at the beginning of the experiments.. Age-matched single transgenic mice (Ins-HA.D2 mice), which express influenza hemagglutinin (HA) peptide, were used and were kindly provided by Dr. Lo (Lo et al., 1992). Freshly prepared STZ (50-200 mg/kg) in saline (pH 4.5 with 0.1 N citrate buffer) was injected intraperitoneally as described previously (Kamei et al., ...
Subjects. Male Tg2576 mice (Hsiao et al., 1996), expressing a double mutation (K670N/M671L) of human APP, were obtained from Taconic (Germantown, NY) and used for subsequent breeding. Transgenic mice heterozygous for the K670N/M671L transgene were maintained on a hybrid C57BL/6/SJL background through breeding hemizygous males with B6SJLF1 females. Genotypes were confirmed by PCR, and animals homozygous for the retinal degeneration mutation were excluded. Individually housed mice, maintained on a 12 h light/dark cycle, had ad libitum access to food and water. Studies were performed comparing heterozygous transgenic (Tg2576) males to age-matched transgene-negative littermates (controls).. β-Amyloid levels. Male Tg2576 mice (20 weeks of age) were given vehicle or 100 mg/kg DAPT orally. Brains from saline-perfused mice (DAPT-treated mice killed 0.5-24 h and vehicle-treated 4 h after dosing) were homogenized in 10:1 (v/w) cold 5 m guanidine, 50 mm Tris-HCl, shaken at room temperature 3 h, then ...
Materials. Diclofenac sodium, CBZ, reserpine, and β-D-glucuronide glucuronosohydrolase (β-glucuronidase, EC 3.2.1.31) were purchased from Sigma-Aldrich (St. Louis, MO). D-SG, D-SNAC, 1-(2,6-dichlorophenyl)indolin-2-one, and D-1-O-G were synthesized as described below. All solvents used for HPLC and LC/MS were of chromatographic grade. Stock solutions of diclofenac (10 mM), D-SG (10 mM), D-1-O-G (1.3 mM), and D-SNAC (10 mM) were prepared as solutions in 50:50 acetonitrile/water (3% formic acid).. Animal Treatment. Male Sprague-Dawley rats (N = 2; 250 -275 g) were purchased from Charles River Breeding Laboratories (Portage, MI). Upon arrival, animals were acclimated following a 12-h light/dark cycle in a humidity- and temperature-controlled environment for 2 weeks in accordance with the National Institutes of Health publication Guide for the Care and Use of Laboratory Animals. After the first week of acclimation, surgically implanted venous and biliary catheters were placed into the superior ...
Tarfa M. P.*, Mshelia P. P., Mahdi O. and Leonard, M. P.. ABSTRACT. Randomly bred normal Forty (40) male albino rats of wistar strain obtained from the wistar rat colony of the Department of Pharmacology, University of Jos, were used for this study. All the animals weighing between 90 - 230 grams and 10 - 20 weeks old were maintained under uniform conditions across ventilated room (temperature 25 - 28oc, and 12h light/dark cycle), with free access to standard diet of Growers Mash (Vital Feed Nig PLC, Maiduguri) and portable water ad Libitum. The rats were divided into groups I, II, III and IV with 10 rats each. However, the rats in groups II, III and IV received oral administration of the solution of Methylene Chloride at 420mg/kg, 840mg/kg and 1260mg/kg respectively for 5 weeks via oro-gastric intubation. Routine histological sections of the testes obtained from rats treated with methylene chloride at all the dose levels (420mg/kg, 840mg/kg and 1260mg/kg) for 5 weeks were characterized by ...
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The U.S. Food and Drug Administration today approved the first pacemaker that does not require the use of wired leads to provide an electrical connection between the pulse-generating device and the heart. While the Micra Transcatheter Pacing System works like other pacemakers to regulate heart rate, the self-contained, inch-long device is implanted directly in the right ventricle chamber of the heart.
Drinking small amounts of alcohol frequently is linked with a higher likelihood of atrial fibrillation than binge drinking, according to research published today in EP Europace, a journal of the European Society of Cardiology (ESC).
The Council on Cardiac Pacing and Electrophysiology endeavors to provide continuing medical education for cardiologists and non-cardiologists on cardiac rhythm disorders, particularly on diagnosis, risk stratification and advances in management, the ultimate goal of which is to enhance the ability of non-electrophysiologists to care for and treat patients with cardiac rhythm disorders.. Chair 2014=2017: Erdie C. Fedriguilan, MD. Immediate Past Chair 2011-2014: Gladys Ruth S. David, ...
Munster head coach Anthony Foley died due to a heart condition which led to a build-up of fluid in his lungs, a French coroner has said.
There are many different types of heart rhythm disorders, each requiring different treatment. Usually, it is not necessary to treat occasional extra heartbeats (so-called extra systole). Rhythm disorders like bradycardia (a heartbeat which is too slow) or tachycardia (a heartbeat which is too fas
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that the molecular clockwork within malignant human pancreatic epithelium is disrupted and that this disruption is mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets the BMAL1 3-UTR and thereby disturbs the pancreatic oscillator, and the downregulation of miR-135b is essential for the realignment of the cellular clock. Asynchrony between miR-135b and BMAL1 expression impairs the local circadian gating control of tumour suppression and significantly promotes tumourigenesis and resistance to gemcitabine in pancreatic cancer (PC) cells, as demonstrated by bioinformatics analyses of public PC data sets and in vitro and in vivo functional studies ...
There were plenty of ooohs and ahhhs at Wellingtons Anzac dawn service today as Rawiri Phillips attended in a handmade soldier uniform his mum stayed up al
Our program offers comprehensive diagnosis and treatment of patients with heart rhythm disturbances and complex heart rhythm disorders
As part of a recent study, researchers tracked more than 10,000 middle-aged people for close to 14 years to understand the connection between microvascular disease and heart rhythm disorder.
Tiazac (diltiazem) is used to treat high blood pressure, angina and certain heart rhythm disorders. Includes Tiazac side effects, interactions and indications.
Cardizem is a calcium channel blocker which is used to treat high blood pressure, chest pain, and certain heart rhythm disorders.
Electrophysiology studies most often are recommended for patients with symptoms indicative of heart rhythm disorders or for people who may be at risk for sudden cardiac death.
Buy Calan Online! Calan is in a group of drugs called calcium channel blockers. Calan is used to treat hypertension, angina and certain heart rhythm disorders. It works by relaxing the muscles of your heart and blood vessels.
Betapace (Sotalol) is used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart ...
The Cardiac Arrhythmia Service is a group of health professionals dedicated to the diagnosis, assessment, management and education of patients who either have or are at risk of developing heart rhythm disorders.
A new blood thinner might be a viable alternative to warfarin (Coumadin), the standard for decades to treat patients with the dangerous heart rhythm disorder kn
My grumpy old lady and I are looking for a place to rent! I work for Coles and mostly do nightshift, and Roxy likes sleeping in high places and screaming at you when you go near her food bowl. Ideally Im looking for my own place but am willing to share with one other relatively clean woman. ...
MIL did something that upset me yesterday and Im not sure how to handle it. She kindly offered to mind DD for me while I had a nap with DS before my nightshift. I never asked where she was going or what she was doing with DD as previously
Chronobiology Circadian advantage Circadian clock Circadian oscillator Circadian rhythm disorders Electronic media and sleep ... Seasonal affective disorder creates a model in which decreased day length during autumn and winter increases depressive ... Reviews in Endocrine & Metabolic Disorders. 10 (4): 301-10. doi:10.1007/s11154-009-9121-9. PMID 19777352. van Bommel WJ (July ... and depressive symptoms in this disorder. Light seems to have therapeutic antidepressant effects when an organism is exposed to ...
Amber-tinted lenses have been shown to affect the circadian rhythm and treat delayed sleep phase disorder. According to the US ... Chronobiology International. 26 (8): 1602-1612. doi:10.3109/07420520903523719. PMID 20030543. Becoming a Squinter Nation ... "Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder ... An open-label trial". Chronobiology International. 33 (8): 1037-1044. doi:10.1080/07420528.2016.1194289. PMID 27322730. S2CID ...
... a circadian rhythm sleep disorder". Chronobiology International. 22 (3): 559-570. doi:10.1081/CBI-200062410. PMID 16076654.. ... "Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder ... Obsessive-compulsive-disorder[edit]. Persons with obsessive-compulsive disorder are also diagnosed with DSPD at a much higher ... Attention deficit hyperactivity disorder[edit]. DSPD is genetically linked to attention deficit hyperactivity disorder by ...
ASPD and non-24-hour sleep-wake disorder are improperly entrained to light/dark. Crepuscular - Animals active at twilight (i.e ... In the study of chronobiology, entrainment occurs when rhythmic physiological or behavioral events match their period to that ... "Basic Science Review on Circadian Rhythm Biology and Circadian Sleep Disorders" (PDF). Annals Academy Med Singapore. 37 (8): ...
Advanced sleep phase syndrome Chronobiology Circadian rhythm Delayed sleep phase disorder "Irregular sleep-wake syndrome: ... "Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, ... Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder ( ... An overnight sleep study is usually not needed to detect this disorder, but may be indicated if other sleep disorders, such as ...
Bipolar disorder - Cardiopulmonary resuscitation - Calvin-Benson cycle - Cell cycle - Chronobiology - Citric acid cycle - ...
"The CLOCK gene and mood disorders: a case-control study and meta-analysis". Chronobiology International. 28 (9): 825-33. doi: ... Bipolar disorder is an affective disorder characterized by periods of elevated and depressed mood. The cause and mechanism of ... Grunze, H. "Bipolar Disorder". In Zigmond, M; Rowland, L; Coyle, J (eds.). Neurobiology of Brain Disorder: Biological Basis of ... The sgACC volume is observed to be reduced not only in bipolar disorder, but also in unipolar disorder, as well as people with ...
Wirz-Justice, A. (2003). "Chronobiology and mood disorders". Dialogues in Clinical Neuroscience. 5 (4): 315-325. PMC 3181777. ... The bipolar disorder is known to have a high heritability. Therefore, sleep disturbances in bipolar disorder could also have a ... The diagnosis of a bipolar disorder is linked to various sleep disorders. Mainly it is very comorbid with Insomnia and ... Rihmer, Zoltán; Kiss, Kitty (2002). "Bipolar disorders and suicidal behaviour". Bipolar Disorders. 4 (s1): 21-25. doi:10.1034/j ...
"Chronotype And Personality Factors Of Predisposition To Seasonal Affective Disorder". Chronobiology International: The Journal ... Bipolar disorder[edit]. With seasonal pattern is a specifier for bipolar and related disorders, including bipolar I disorder ... "What is SAD (Seasonal Affective Disorder)?". Retrieved February 21, 2018.. *^ "Depression" (PDF). Mood Disorders Society of ... Seasonal affective disorder (SAD) is a mood disorder subset in which people who have normal mental health throughout most of ...
Colony collapse disorder, bees "Российские экологи бьют тревогу: исчезающих из домов тараканов хотят переселить в Красную книгу ... Ozone holes may also lead to abnormal chronobiology in cockroaches. Internal competitions between cockroaches may decrease the ...
Some night owls with great difficulty adopting normal sleeping and waking times may have delayed sleep-phase disorder. Morning ... Chronobiology (2004) Sleep Discrimination Intelligence and Creativity in Night Owls vs. Early Birds[permanent dead link] with ... Laura H. Smith/Charles H. Elliott, Seasonal Affective Disorder for Dummies (2007) p. 73 Maestripieri, Dario (2014-01-01). " ... the study of sleep cycles and other time-dependent biological systems Circadian rhythm sleep disorder Insomnia - the inability ...
생물에서 하루, 조수, 주간, 계절, 그리고 일 년과 같이 시간에 따른 리듬을 연구하는 학문을 시간 생물학(chronobiology)라고 한다. 생체 리듬은 체내에서 발생하지만 일주기 생체 리듬은 빛, 어둠, 기온과 같은 외부의 ... 영국에서는 약 3퍼센트가 가을이나 겨울에 계절성정서장애(SAD: seasonal affective disorder)를 겪는다고 한다. 이 질병은 봄이 되면 증상이 호전되는데 이 증상은 동물들이 동면할 때 에너지를 절감하는 현상과 ... Okawa, M. Uciyama, M. Ozaki, S. Shibui, K. Ichikawa, H. (1998). "Circadian rhythm sleep disorders in adolescents: clinical ... trials of combined treatments based on chronobiology". Psychiatry Clin neurosci 52: 483-490. DOI: 10.1046/j.1440-1819.1998. ...
Some night owls with great difficulty adopting normal sleeping and waking times may have delayed sleep-phase disorder. Morning ... Chronobiology - the study of sleep cycles and other time-dependent biological systems ... Laura H. Smith/Charles H. Elliott, Seasonal Affective Disorder for Dummies (2007) p. 73 ... Delayed sleep phase disorder - an extreme form of being a night owl ...
In: Trends in Chronobiology, ed. Hekkens W, Th JM, Jerkhof GA and Rhietveld WJ, Pergamon Press, Oxford and New York, pp. 149- ... His later work was more applicable to pathologies, such as psychiatric disorders and dangers of shift work schedules, which can ... Together with Erwin Bünning and Colin Pittendrigh, he is considered to be a co-founder of the field of chronobiology. Aschoff's ... Aschoff's work in the field of chronobiology introduced the idea that shifting one's light-dark cycle can result in harmful ...
Wehr and colleague Anna Wirz-Justice were awarded the Anna-Monika Prize for their work in the chronobiology of depressive ... Wehr and colleague Norman E. Rosenthal are credited with identifying and describing Seasonal Affective Disorder (SAD) and ... "Circadian Sleep Disorders," Nightline, February 21, 1996 "Body Clocks," The Infinite Mind, February 20, 2008 Science Magazine ...
... metabolic disorders, gastrointestinal disorders, musculoskeletal disorders, and reproductive disorders. Shift work also can ... Chronobiology International. 29 (9): 1153-1175. doi:10.3109/07420528.2012.719971. PMID 23004349. S2CID 7565248. Ftouni, Suzanne ... Shift work sleep disorder is a circadian rhythm sleep disorder characterized by insomnia, excessive sleepiness, or both. Shift ... Shift work sleep disorder also creates a greater risk for human error at work. Shift work disrupts cognitive ability and ...
Subsets of functional neurological disorders include functional neurological symptom disorder (FNsD), conversion disorder, and ... "Functional neurologic disorders/conversion disorder". Mayo Clinic.. *^ Wessely, Simon; White, Peter D. (2004-08-01). "There is ... single disorder than separate disorders.[25] References[edit]. *^ a b Carson, A. et al. Disability, distress and unemployment ... Edwards, M. J., Stone, J. & Lang, A. E. From psychogenic movement disorder to functional movement disorder: It's time to change ...
"MedlinePlus: Movement Disorders".. *^ Baizabal-Carvallo, JF; Jankovic J. (2012-07-18). "Movement disorders in autoimmune ... In secondary movement disorders, the abnormal movement is a manifestation of another systemic or neurological disorder.[3] ... Treatment depends upon the underlying disorder.[6] Movement disorders have been known to be associated with a variety of ... In primary movement disorders, the abnormal movement is the primary manifestation of the disorder. ...
Seasonal affective disorder may occur as a result of deficiencies in zeitgebers (such as light) during the winter months that ... Carrier, Julie; Monk, Timothy H. (2000). "Circadian Rhythms of Performance: New Trends". Chronobiology International. 17 (6): ... For bipolar disorder, Interpersonal and Social Rhythm Therapy (IPSRT) is meant to regulate and normalize an individual's social ... This possibility may help to explain the relationship between stressful life events and the development of mood disorders. For ...
Willis, G. L. (2008). "Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and ... Chronobiology International. 24 (3): 521-537. doi:10.1080/07420520701420717. PMID 17612949.. ... that undertakes clinical and basic research into disorders of brain function and addresses problems of altered biological ...
Gian F. Placidi; Liliana Dell'Osso; Giuseppe Nistico; Hagop S. Akiskal (6 December 2012). Recurrent Mood Disorders: New ... Chronobiology International. 11 (2): 65-71. doi:10.3109/07420529409055892. PMID 8033243. Hougardy, E.; Pernet, P.; Warnau, M.; ...
"Sleep disorders linked to poor health and reduced occupational performance in police officers". National Sleep Foundation. Jan ... As a Team Leader of the Human Performance Factors, Sleep and Chronobiology Team at the NASA National Space Biomedical Research ... Münch M, Bromundt V (Dec 2012). "Light and chronobiology: implications for health and disease". Dialogues in Clinical ... Awarded by the Society for Research on Biological Rhythms for his contributions to the field of Chronobiology in 2001 The NIOSH ...
... (程 肇, テイ ハジメ born March 1959) is a Japanese neuroscientist specializing in the study of chronobiology. He currently ... This promoter sequence allows for the creation of transgenic animals that will be useful in studying circadian disorders and ... Hajime Tei received the 13th Tsukahara Memorial Award in 1999, and the Aschoff-Honma Prize for chronobiology in 2001. In 1997, ... Chronobiology International. 19 (5): 807-64. doi:10.1081/CBI-120014569. PMID 12405549. S2CID 16148967. Koike N, Hida A, Numano ...
However, he quickly developed a passion for research after working as an undergraduate student in a chronobiology lab directed ... The lab hopes to find chronotherapeutic ways to ameliorate the sleep disorders of patients suffering from this syndrome. 1982: ... Currently, the idea that bacterial circadian rhythms exist in at least some prokaryotes is well accepted by the chronobiology ... Carl Hirschie Johnson is an American-born biologist who researches the chronobiology of different organisms, most notably the ...
In chronobiology, an ultradian rhythm is a recurrent period or cycle repeated throughout a 24-hour day. In contrast, circadian ... Ultradian mood states in bipolar disorder cycle much faster than rapid cycling; the latter is defined as four or more mood ...
Sleep disorder in elderly patients with dementia and trials of new treatments -- enforcement of social interaction and bright ... Chronobiology International. 26(4):726-739. http://www.lrc.rpi.edu/programs/lightHealth/projects/Elderly.asp?id=167 Avery, D H ... Many researchers have linked the depression to seasonal affective disorder (SAD), and seasonal mood variations have been linked ... 1995). "Clinical and chronobiological effects of light therapy on nonseasonal affective disorders". Biol Psychiatry. 37 (12): ...
Delayed sleep phase disorder is a medical disorder characterized by delayed sleeping time and a proportionately delayed waking ... Chronobiology International, 15(1), 71-83. Burgess, H. J., Revell, V. L., Eastman, C. I. (2008). A three pulse phase response ... "Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders An American Academy of Sleep ... Delayed sleep phase disorder Sleep deprivation Kalat, James W. (8 February 2018). Biological Psychology (13 ed.). Cengage. p. ...
Chronic circadian rhythm disorders, the most common of which is delayed sleep phase disorder, may be managed by specifically- ... Due to the rapidly increasing knowledge about sleep, including the growth of the research field chronobiology from about 1960 ... The last two subgroups were (3) the medical or psychiatric sleep disorder section and (4) the proposed new disorders section. ... The International Classification of Sleep Disorders lists more than 80 different sleep disorder diagnoses. Sigurdson K; Ayas NT ...
Even single neurons have complex biophysical characteristics and can perform computations (e.g.[19]). Hodgkin and Huxley's original model only employed two voltage-sensitive currents (Voltage sensitive ion channels are glycoprotein molecules which extend through the lipid bilayer, allowing ions to traverse under certain conditions through the axolemma), the fast-acting sodium and the inward-rectifying potassium. Though successful in predicting the timing and qualitative features of the action potential, it nevertheless failed to predict a number of important features such as adaptation and shunting. Scientists now believe that there are a wide variety of voltage-sensitive currents, and the implications of the differing dynamics, modulations, and sensitivity of these currents is an important topic of computational neuroscience.[20] The computational functions of complex dendrites are also under intense investigation. There is a large body of literature regarding how different currents interact ...
... is able to detect consistent patterns of abnormalities in patients with subtle cognitive dysfunctions and psychiatric disorders ...
Medical disordersEdit. AutismEdit. Music has played an important role in the research of dealing with autism, mainly in ... such as mood/anxiety disorders and eating disorders, or inappropriate behaviors, including suicide attempts, withdrawal from ... Crowe, Barbara J. (2007). Music Therapy for Children, Adolescents and Adults with Mental Disorders. Silver Spring, MD: American ... Psychiatric disordersEdit. A 2016 meta-analysis on the effects of music therapy in schizophrenic patients showed that the ...
The scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system. ... Psychiatry focuses on affective, behavioral, cognitive, and perceptual disorders. Anesthesiology focuses on perception of pain ... surgical practice of either drilling or scraping a hole into the skull for the purpose of curing headaches or mental disorders ...
"Chronobiology International: The Journal of Biological and Medical Rhythm Research. 25 (1): 65-81. doi:10.1080/ ... Circadian disruption may lead to numerous health problems including breast cancer, seasonal affective disorder, delayed sleep ...
Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, ... An imbalance between excitation and inhibition is seen to be implicated in a number of neuropsychiatric disorders.[62] ...
... is also used as an integral part of understanding and treating neurobiological brain disorders. One example ...
Neurological disorders[edit]. While the genetic basis of simple diseases and disorders has been accurately pinpointed, the ... the progression of neurodegenerative disorders, the persistence of periodic disorders, and the effects of mitochondrial decay ... With severe disorders such as epilepsy, brain malformations, or mental retardation a single gene or causative condition has ... Many of the disorders studied early on including Alzheimer's, Huntington's and amyotrophic lateral sclerosis (ALS) are still at ...
In an attempt to focus and clarify what was a growing interest in this field, in 1994 educator and businessman Laurence O. McKinney published the first book on the subject, titled "Neurotheology: Virtual Religion in the 21st Century", written for a popular audience but also promoted in the theological journal Zygon.[9] According to McKinney, neurotheology sources the basis of religious inquiry in relatively recent developmental neurophysiology. According to McKinney's theory, pre-frontal development, in humans, creates an illusion of chronological time as a fundamental part of normal adult cognition past the age of three. The inability of the adult brain to retrieve earlier images experienced by an infantile brain creates questions such as "where did I come from" and "where does it all go", which McKinney suggests led to the creation of various religious explanations. The experience of death as a peaceful regression into timelessness as the brain dies won praise from readers as varied as author ...
pediatric neurosurgery (for cancer, seizures, bleeding, stroke, cognitive disorders or congenital neurological disorders) ... Repair of craniofacial disorders and disturbance of cerebrospinal fluid circulation is done by neurosurgeons who also ... Some forms of movement disorders (advanced پارکینسون، chorea) - this involves the use of specially developed minimally invasive ... Some forms of movement disorders (advanced Parkinson's disease, chorea) - this involves the use of specially developed ...
Alzheimer Disease & Associated Disorders. *Alzheimer's & Dementia. *Ambulatory Pediatrics. *American Journal of Anatomy ... Chronobiology International. *Circulation Research. *Clinical Anatomy. *Clinical and Experimental Hypertension. *Clinical ...
Cultural differences exist in the ventral visual cortex and many studies have shown this. In a study conducted in 2005 they found that East Asians were more likely to keep their eyes focused on background scenes than westerners who would instead focus more on the central object such as a giraffe in a savanna. In a similar 2006 study it showed that in congruence to the difference in society structure westerners showed more activation in object processing regions, including the bilateral middle temporal gyrus, left superior parietal gyrus, and right superior temporal gyrus, although no activation differences were observed in context-processing regions such as the hippocampus. However, there has been some research contradicting cultural bias in the oculomotor control such as one conducted in 2007 by Rayner, Li, Williams, Cave, and well who failed to find evidence that East Asians focus more on context although they did find evidence that they are more likely to focus less on central objects. In a ...
Mood disorders[edit]. Main article: Mood disorder. Depression, chronic stress, bipolar disorder, etc. are considered mood ... Jankowski, K.S. (2014). "The role of temperament in the relationship between morningness-eveningness and mood". Chronobiology ... mood disorder) and for anxiety disorders in women.[16] Red meat is found to be protective against mood and anxiety disorders.[ ... Long term disturbances of mood such as clinical depression and bipolar disorder are considered mood disorders. Mood is an ...
It is clear from multiple lines of evidence that all researched behavioural traits and disorders are influenced by genes; that ... in human studies are small, negligible, or zero for the vast majority of behavioural traits and psychiatric disorders, whereas ... metric, the effects of individual genetic variants on complex human behavioural traits and disorders are vanishingly small, ... Finally, there are classical behavioural disorders that are genetically simple in their etiology, such as Huntington's disease ...
... balance and vision disorders, and seizures,[1] and in humans other disorders such as Rett syndrome, Down syndrome and ... Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders ...
Circa 1000, Al-Zahrawi, living in Iberia, began to write about different surgical treatments for neurological disorders. In ... believed that relaxation and a stress free environment was crucial in helping treat neurological disorders. In 280 B.C., ...
Chronic circadian rhythm disorders, the most common of which is delayed sleep phase disorder, may be managed by specifically- ... Due to the rapidly increasing knowledge about sleep, including the growth of the research field chronobiology from about 1960 ... Main article: Sleep disorder. Competence in sleep medicine requires an understanding of a plethora of very diverse disorders, ... The last two subgroups were (3) the medical or psychiatric sleep disorder section and (4) the proposed new disorders section. ...
As a clinician, he and his collaborators have studied and treated disorders of behaviour and cognition, and movement disorders ...
Other disorders. Sleep disorders include narcolepsy, periodic limb movement disorder (PLMD), restless leg syndrome (RLS), upper ... Mann, Joseph John; David J. Kupfer (1993). Biology of Depressive Disorders: Subtypes of depression and comorbid disorders, Part ... Sleep difficulties are furthermore associated with psychiatric disorders such as depression, alcoholism, and bipolar disorder.[ ... parasomnias such as sleepwalking and REM behavior disorder; bruxism; and circadian rhythm sleep disorders. The advent of ...
By comparing how often a certain disorder occurs in a pair of identical twins to how often it occurs in a pair of fraternal ... "Brigham and Women's Hospital: Information Center for Sickle Cell and Thalassemic Disorders. 11 April 2002. Archived from the ... International Journal of Obesity and Related Metabolic Disorders. 25 (7): 1034-41. doi:10.1038/sj.ijo.0801650. PMID 11443503.. ... "Mapping the new frontier: complex genetic disorders". The Journal of Clinical Investigation. 115 (6): 1404-7. doi:10.1172/ ...
Evolutionary psychology has proposed several explanations for love. Monkey infants and children are for a very long time dependent on parental help. Love has therefore been seen as a mechanism to promote mutual parental support of children for an extended time period. Another is that sexually transmitted diseases may cause, among other effects, permanently reduced fertility, injury to the fetus, and increase risks during childbirth. This would favor exclusive long-term relationships reducing the risk of contracting an STD.[1] From the perspective of evolutionary psychology the experiences and behaviors associated with love can be investigated in terms of how they have been shaped by human evolution.[2] For example, it has been suggested that human language has been selected during evolution as a type of "mating signal" that allows potential mates to judge reproductive fitness.[3] Miller described evolutionary psychology as a starting place for further research: "Cognitive neuroscience could try ...
Chronobiology International. 27 (2): 251-264. doi:10.3109/07420521003664213. PMID 20370468.. CS1 maint: Multiple names: authors ... Disorders of ocular muscles, binocular movement, accommodation and refraction. *Vision. Hidden categories: *Webarchive template ...
Mental or social disorders or behaviours seen as generally unhealthy or excessive in a given individual, to the point where ... All infectious and organic diseases and physiological disorders. Significant tests. All medical diagnostic tests, particular ... Psychopathology is the study of mental illness, particularly of severe disorders. Informed heavily by both psychology and ... Although diagnosis and classification of mental norms and disorders is largely the purview of psychiatry-the results of which ...
Recent studies in clinical chronobiology have revealed that a chronic sleep phase delay (delayd sleep phase syndrome (DSPS)), ... Though these disorders have been studied for about 20 years, there have been few hypotheses on their pathophysiology or ... Publications] Uchiyama M,Ozaki S: Diagnosis and treatment of insomnia In sleep-wake disorders, ed by Meier-Ewert K,Okawa M. ... Publications] Negro PJ,Faber R,Uchiyama M,et al.: Lewy body disease in a patient with REM sleep behavior disorder Neurology. ...
Wirz-Justice, A. (2003). "Chronobiology and mood disorders". Dialogues in Clinical Neuroscience. 5 (4): 315-325. PMC 3181777. ... The bipolar disorder is known to have a high heritability. Therefore, sleep disturbances in bipolar disorder could also have a ... The diagnosis of a bipolar disorder is linked to various sleep disorders. Mainly it is very comorbid with Insomnia and ... Rihmer, Zoltán; Kiss, Kitty (2002). "Bipolar disorders and suicidal behaviour". Bipolar Disorders. 4 (s1): 21-25. doi:10.1034/j ...
"The CLOCK gene and mood disorders: a case-control study and meta-analysis". Chronobiology International. 28 (9): 825-33. doi: ... Bipolar disorder is an affective disorder characterized by periods of elevated and depressed mood. The cause and mechanism of ... Grunze, H. "Bipolar Disorder". In Zigmond, M; Rowland, L; Coyle, J (eds.). Neurobiology of Brain Disorder: Biological Basis of ... The sgACC volume is observed to be reduced not only in bipolar disorder, but also in unipolar disorder, as well as people with ...
Chronobiology of mood disorders. Acta Psychiatrica Scandinavica. Volume 128, Issue s444, September 2013, Pages: 2-15, G. S. ... Is it Trauma- or Fantasy-based? Comparing dissociative identity disorder, post-traumatic stress disorder, simulators, and ... Lithiums role in neural plasticity and its implications for mood disorders. Acta Psychiatrica Scandinavica. Volume 128, Issue ... Use of psychotropic drugs in patients with autism spectrum disorders: a systematic review. Acta Psychiatrica Scandinavica. ...
Chronobiology of Mood Disorders Felice Iasevoli, Livia Avvisati, Valentina Gilardi, Gianmarco Latte, Emiliano Prinzivalli, ... Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the ... Agomelatine Chronobiology of mood disorders Hippocampal neurogenesis, depression and antidepressants Melatonergic drugs in ... Sleep Abnormalities as a Diagnostic Tool for Major Depressive Disorder Alan B. Douglass, Marcus Ward, Timothy Roerhrs, Cynthia ...
Chronobiology Disorders. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Nervous System Diseases. ... Circadian Rhythm Disorders Anxiety Breast Cancer Device: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring ...
Mental Disorders. Neurobehavioral Manifestations. Neurodevelopmental Disorders. Behavioral Symptoms. Chronobiology Disorders. ... Developmental Delay Disorders Chromosome Deletion Mental Retardation Sleep Disorders, Circadian Rhythm Self Injurious Behavior ... Sleep Wake Disorders. Parasomnias. Self-Injurious Behavior. Smith-Magenis Syndrome. Sleep Disorders, Circadian Rhythm. ... Individuals who have been diagnosed with a sleep disorder (e.g, restless legs, sleep apnea) known to impact sleep may be ...
A history or current diagnosis of a primary sleep disorder (insomnia, sleep apnea, circadian rhythm sleep disorder, restless ... and metabolic disorders. Over the past two decades, molecular geneticists have cracked the clock to reveal its core ... and metabolic disorders. Over the past two decades, molecular geneticists have cracked the clock to reveal its core ... metabolic and sleep disorders. Yet the prevalence of circadian disruption in these patient populations is unclear because ...
Chronobiology. Horm Res 1990;33:53-7. 2. Monteleone P, Maj M. The circadian basis of mood disorders: recent developments and ... Wirz-Justice A. Chronobiology and mood disorders. Dialogues Clin Neurosci 2003;5:315-25. 26. Wirz-Justice A. Circadian rhythms ... Translational research in chronobiology can provide insights into the diagnostic and therapeutic processes of mood disorders in ... Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders ...
Chronobiology Disorders * Female * Humans * Male * Melatonin / deficiency * Middle Aged * Occupational Exposure / statistics & ...
Chronobiology and psychiatric disorders. New York: Elsevier Science Publishing Co., 1987: 241-62Google Scholar ... Chronobiology of man: sleep, temperature and neuroendocrine rhythms. Hum Neurobiol 1982; 1: 173-83PubMedGoogle Scholar ... Chronobiology: principles and applications to shifts in schedules. Rockville (MD): Sijthoff & Noordhoff, 1980: 417-31Google ...
... movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in ... Nine sections focus on specific groups of disorders-disorders of development; schizophrenia and related disorders; anxiety and ... affective disorders; Alzheimers and other dementias; substance use disorders; impulsive and compulsive disorders; ... Chapter 42: Current And Emerging Therapeutics Of Autistic Disorder And Related Pervasive Developmental Disorders (PDF) ...
Chronobiology Disorders / metabolism* * Circadian Rhythm* * Cryptochromes / genetics * Cryptochromes / metabolism * Female * ...
Malhi GS, Kuiper S. Chronobiology of mood disorders. Acta Psychiatr Scand Suppl 2013(444):2-15. [CrossRef] [Medline] ... MDD: major depressive disorder; BD I: bipolar I disorder; BD II: bipolar II disorder; AUC: area under the curve. View this ... MDD: major depressive disorder; BD I: bipolar I disorder; BD II: bipolar II disorder; HR: heart rate; CR: circadian rhythm. ... MDD: major depressive disorder; BD I: bipolar type I disorder; BD II: bipolar type II disorder; HR: heart rate; CR: circadian ...
Chronobiology and mood disorders. «Dialogues in Clinical Neuroscience», 2003;5:315-325. ... Journal of Affective Disorders», 2005;85:231-239; H.S. Akiskal, K. Akiskal, J.F. Allilaire, J.M. Azorin, M.L. Bourgeois, D. ... Journal of Affective Disorders», 2004;81:91-102. Z. Kronfol, D.G. Remick. Cytokines and the brain: implications for clinical ... Mood disorders in stroke patients: importance of location of lesion. «Brain», 1984;107:81-93; S.E. Starkstein, R.G. Robinson, T ...
Sleep Disorders Clinic of The. Centre for Sleep & Chronobiology. Unit 15. 951 Wilson Avenue. Toronto ON M3K 2A7. Canada. Phone: ... Chronobiology. 295 College St. Suite 301. Toronto ON M5T 1S2. Phone: (416) 603-9531. Fax: (416) 603-2388 Electoral District: 10 ...
... a circadian rhythm sleep disorder". Chronobiology International. 22 (3): 559-570. doi:10.1081/CBI-200062410. PMID 16076654.. ... "Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder ... Obsessive-compulsive-disorder[edit]. Persons with obsessive-compulsive disorder are also diagnosed with DSPD at a much higher ... Attention deficit hyperactivity disorder[edit]. DSPD is genetically linked to attention deficit hyperactivity disorder by ...
Chronobiology Disorders; Circadian Rhythm Sleep Disorders; Connective Tissue Diseases; De Quervain Disease; Dysautonomia; ... Key words: ALS; Amyotrophic Lateral Sclerosis; Arnold Chiari Syndrome; Arthrogryposis; Atrophic Muscular Disorders; Autonomic ... Spinal Disorders; Spondylitis; Spondylolisthesis; Tendinitis; Tennis Elbow; Tenosynovitis; Tietzes Syndrome; Tuberous Sclerosis ...
Circadian rhythm sleep disorders in adolescents: clinical trials of combined treatments based on chronobiology. Psychiatry Clin ... Sleep disorders. Taking vitamin B12 by mouth does not seem to help people with sleep disorders. ... sleep disorders, depression, mental disorders, schizophrenia, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory ... Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720- ...
... neurotoxic disorders (neuropathology, chronobiology, diketone exposures, peripheral nervous effects, neurophysiology, ... trauma disorders from repetitive tasks, and ergonomics); occupational cancers (agricultural workers, agricultural chemicals, ... psychologic disorders from solvent exposures; respirators; control technology; and other occupational concerns. ... reproductive disorders (pesticides, fertility studies, mutagens, carbon-disulfide (75150), biotransformation, congenital ...
Epidemiology and etiology of depressive disorders. Neurobiology of depression. Chronobiology of seasonal mood disorders. ... Part III: Bipolar Disorders in Children and Adolescents. Bipolar disorders: natural history, genetic studies, and follow-up. ... Frequently these disorders are comorbid with other psychiatric disorders. This volume integrates concisely yet comprehensively ... and chronobiology of seasonal mood disorders. A section on diagnostic assessment and treatment addresses standardizes ...
You are here: Research Topics , diseases , nervous system diseases , chronobiology disorders , circadian rhythm sleep disorders ... Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, ... Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, ... disorders of excessive somnolence*sleep deprivation*sleep disorders*sleep initiation and maintenance disorders*personnel ...
Although the genetic basis of seasonality and seasonal affective disorder (SAD) has not been established so far, there is ... Although the genetic basis of seasonality and seasonal affective disorder (SAD) has not been established so far, there is ... exert a marked influence on the behavior of patients affected by mood disorders. Here we review recent findings about the ... exert a marked influence on the behavior of patients affected by mood disorders. Here we review recent findings about the ...
Chronobiology and Mood Disorders. Yavuz Selvi, L tfullah Be iro lu, Adem Ayd n. Psikiyatride Guncel Yaklasimlar - Current ... Organic personality disorder after aneurysm surgery: a case report. P nar G zel zdemir, Yavuz Selvi, Adem Ayd n. D nen Adam: ... Journal of Mood Disorders. 2011; 1(4): 169-177.. *Giant Mature Adrenal Cystic Teratoma in an Infant. Ilhan Ciftci, Tugba Cihan ... Journal of Mood Disorders. 2011; 1(4): 152-161.. * In vitro cytogenetic effects of moxifloxacin Lale Donbak; Ahmet Kayraldiz; ...
Chronobiology and psychiatric disorders. New York:Elsevier, pp. 263-289. * Manji, HK and Lenox, RH (2000). The nature of ... Lenox, HL, Gould, TD and Manji, HK (2002). Endophenotypes in bipolar disorder. Am J Med Genet 114: 391-406, [PubMed] DOI: https ... Bipolar disorder is a common, chronic, severe, and often life-threatening illness, characterized by recurrent episodes of two ... Background: Bipolar disorder (BPD) is a widespread condition characterized by recurring states of mania and depression. Lithium ...
Chronobiology and Mood Disorders. Yavuz Selvi, L tfullah Be iro lu, Adem Ayd n. Psikiyatride Guncel Yaklasimlar - Current ... Journal of Mood Disorders. 2011; 1(4): 169-177.. *The relationship between insomnia and major depressive disorder: a chicken ... Journal of Mood Disorders. 2013; 3(1): 1-7.. *Surgical approach and problems in limb salvage after a pig bite. Adem G ler1, ... Organic personality disorder after aneurysm surgery: a case report. P nar G zel zdemir, Yavuz Selvi, Adem Ayd n. D nen Adam: ...
Sara Dallaspezia, Francesco Benedetti, Chronobiology of Bipolar Disorder: Therapeutic Implication, Current Psychiatry Reports, ... 2009) Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar ... Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and daily activity that often ... Mansour, H.A., Monk, T.H. & Nimgaonkar, V.L. (2005) Circadian genes and bipolar disorder. Ann Med 37, 196-205.. *CrossRef , ...
In a given year, about 5 percent of the U.S. population experiences seasonal affective disorder, with symptoms present for ... Seasonal affective disorder is a combination of biologic and mood disturbances with a seasonal pattern, typically occurring in ... The chronobiology and neurobiology of winter seasonal affective disorder. Dialogues Clin Neurosci. 2007;9(3):315-324. ... cyclothymic disorder, dysthymic disorder, premenstrual dysphoric disorder, chronic fatigue syndrome, hypothyroidism, and drug ...
The chronobiology and neurobiology of winter seasonal affective disorder 1 minute ago ...
Circadian rhythms : biology, cognition and disorders. Circadian rhythms, Chronobiology Disorders, Circadian Rhythm, sähkökirjat ... Platelets, Blood Platelets, Blood Platelet Disorders, Blood platelets, sähkökirjat, Blood platelet disorders ...
Medical Chronobiology Program, Division of Sleep and Circadian Disorders, BWH. 221 Longwood Avenue (BLI-044). Boston, MA 02115 ... Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Womens Hospital Medical Biodynamics ... Medical Chronobiology Program. Brigham and Womens Hospital. Journal of Circadian Rhythms (Editor). Journal of Geriatric ... "Sleep, Aging, and Circadian Rhythm Disorders". Role: Co-Investigator. NIDDK R01 DK099512; PI: F.A.J.L. Scheer. "Meal Time ...
  • Bipolar disorder is an affective disorder characterized by periods of elevated and depressed mood. (wikipedia.org)
  • The "kindling model" of mood disorders suggests that major environmental stressors trigger initial mood episodes, but as mood episodes occur, weaker and weaker triggers can precipitate an affective episode. (wikipedia.org)
  • Various circadian rhythm abnormalities have been demonstrated in mood disorders such as unipolar depression, bipolar depression and seasonal affective disorder. (balkanmedicaljournal.org)
  • Hypotheses involving circadian rhythm abnormalities related to the etiology of mood disorders have been raised. (balkanmedicaljournal.org)
  • The resulting circadian rhythm changes can be measured and evaluated that these techniques can be used to identify subtypes of mood disorders associated with circadian rhythm changes. (balkanmedicaljournal.org)
  • Chronobiological research has been applied to the psychiatric clinic and light therapy has been used as a chronotherapeutic in the treatment of mood disorders. (balkanmedicaljournal.org)
  • On the other hand, chronotherapeutic approaches with effects on circadian rhythms such as sleep deprivation therapy have been used in the treatment of mood disorders too. (balkanmedicaljournal.org)
  • It may be possible, the data obtained from the basic sciences are used in the diagnosis of mood disorders and in the treatment of psychiatric disorders as chronotherapeutic techniques. (balkanmedicaljournal.org)
  • Circadian rhythm disruptions are also seen in many psychiatric disorders, particularly mood disorders (6). (balkanmedicaljournal.org)
  • The present article continues to use the term "mood disorders" rather than the new classification in the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 to ensure easy understanding. (balkanmedicaljournal.org)
  • Circadian rhythms are associated with various human states, especially mood disorders, and disturbance of the circadian rhythm is known to be very closely related. (jmir.org)
  • Attempts have also been made to derive clinical implications associated with mood disorders using the vast amounts of digital log that is acquired by digital technologies develop and using computational analysis techniques. (jmir.org)
  • The book begins with a discussion of depression's clinical manifestations, including epidemiology, neurobiology, and chronobiology of seasonal mood disorders. (whsmith.co.uk)
  • Thus, seasonality plays a major role in mood disorders, affecting psychopathology, and representing the behavioral correlate of a heightened sensitivity to factors influencing circannual rhythms in patients. (frontiersin.org)
  • Although the genetic basis of seasonality and seasonal affective disorder (SAD) has not been established so far, there is growing evidence that factors affecting the biological clock, such as gene polymorphisms of the core clock machinery and seasonal changes of the light-dark cycle, exert a marked influence on the behavior of patients affected by mood disorders. (frontiersin.org)
  • The identification of the molecular target(s) of mood stabilizers would not only facilitate the development of improved modes of treatment, but also provide a basis for the delineation of the pathophysiology of affective mood disorders. (jcircadianrhythms.com)
  • Bipolar disorder (BD) is a psychiatric illness characterized by severe, episodic mood disturbances that include distinct periods of mania and depression. (wiley.com)
  • Seasonal affective disorder is a combination of biologic and mood disturbances with a seasonal pattern, typically occurring in the autumn and winter with remission in the spring or summer. (aafp.org)
  • Seasonal affective disorder (SAD) is a combination of biologic and mood disturbances with a seasonal pattern. (aafp.org)
  • Seasonal affective disorder ( SAD ) is a mood disorder subset in which people who have normal mental health throughout most of the year exhibit depressive symptoms at the same time each year, most commonly in winter. (wikipedia.org)
  • It is no longer classified as a unique mood disorder but is now a specifier, called "with seasonal pattern", for recurrent major depressive disorder that occurs at a specific time of the year and fully remits otherwise. (wikipedia.org)
  • Seasonal affective disorder (SAD) is a mood disorder in which major depressive episodes and/or manic episodes occur at predictable times of the year, with depressive episodes typically occurring during the fall and winter months. (encyclopedia.com)
  • SAD is also sometimes called seasonal mood disorder. (encyclopedia.com)
  • J. Christian Gillin, a professor of psychiatry at the University of California, San Diego, conducts research on sleep, chronobiology and mood disorders. (scientificamerican.com)
  • During that time he did not feel sleepy or tired and did not show any disorders of mood, memory, or anxiety. (scientificamerican.com)
  • He is particularly interested in the neural bases underlying inter-individual differences in human risk-taking and decision-making and the vulnerability to addiction, mood disorders, sleep loss, and fatigue. (upenn.edu)
  • People with seasonal affective disorder have difficulty regulating the neurotransmitter serotonin, a neurotransmitter believed to be responsible for balancing mood [ 2 ]. (hindawi.com)
  • Symptoms of winter seasonal pattern disorders center on sad mood and low energy [ 14 - 18 ]. (hindawi.com)
  • Mounting evidence shows the endogenous opioid system is a potential therapeutic target for mood disorders, yet questions remain. (psychiatrictimes.com)
  • One such disorder, seasonal affective disorder (SAD), is characterized by seasonal mood changes which is typically seen as autumn or winter depression that spontaneously remits during spring and summer. (technologynetworks.com)
  • Recent advances in our understanding of the fundamental links between chronobiology and major mood disorders, as well as the development of new drugs that target the circadian system, have led to a renewed focus on this area. (healthcanal.com)
  • They conclude: "As agomelatine does not raise serotonin levels, it has less potential for the common gastrointestinal, sexual, or metabolic side-effects that characterise many other antidepressant compounds… Because of its favourable adverse effect and safety profile, and the potential to help to restore circadian function between depressive episodes, this drug might occupy a unique place in the management of some patients with severe depression and other major mood disorders. (healthcanal.com)
  • Agomelatine is currently approved in the EU, US and Australia, and represents a significant step forward in the approach to the treatment of depression, and other mood disorders. (healthcanal.com)
  • Differences in a person's circadian rhythm - such as any changes in light exposure, motor activity and temperature cycles - may help in the diagnosis and treatment of depressive mood disorders, according to new research conducted by the Chronobiology Laboratory in Porto Alegre, Brazil. (psychcentral.com)
  • The evidence was insufficient for mood disorders and general health. (bmj.com)
  • Objective: Circadian dysregulation plays an important role in the etiology of mood disorders. (bvsalud.org)
  • However, prospective studies about the influence of chronotype on mood symptoms have reached unclear conclusions in patients with bipolar disorder (BD). (bvsalud.org)
  • Objective:Circadian disturbances common to modern lifestyles have been associated with mood disorders. (bvsalud.org)
  • SBRI research is a multidisciplinary with interests ranging from stem cells biology, developmental neurobiology , integrative and cognitive neuroscience , chronobiology disorders and robotics . (sbri.fr)
  • 1. Levitan RD (2007) The chronobiology and neurobiology of winter seasonal affective disorder. (technologynetworks.com)
  • Collaborative efforts among these labs are facilitated through the Penn's Center for Sleep and Circadian Neurobiology and Penn Chronobiology Program. (upenn.edu)
  • This review summarizes research on the chronobiology and neurobiology of winter seasonal affective disorder (SAD), a recurrent subtype of depression characterized by a predictable onset in the fall/winter months and spontaneous remission in the spring/summer period. (internetandpsychiatry.com)
  • In light of associations between bipolar and circadian abnormalities (such as decreased need for sleep and increased sleep latency), polymorphisms in the CLOCK gene have been tested for association, although findings have been inconsistent, and one meta analysis has reported no association with either bipolar or major depressive disorder. (wikipedia.org)
  • [5] Most people with SAD experience major depressive disorder , but as many as 20% may have a bipolar disorder . (wikipedia.org)
  • [12] In these cases, people who have the With seasonal pattern specifier may experience a depressive episode either due to major depressive disorder or as part of bipolar disorder during the winter and remit in the summer. (wikipedia.org)
  • The term SAD can also be applied to depressive episodes with a seasonal pattern that do not meet the criteria for major depressive disorder or a bipolar disordermajor depressive disorder (i.e., subsyndromal). (encyclopedia.com)
  • According to the Diagnostic and Statistic Manual, Fourth Edition (DSM-IV-TR)major depressive disorder of the American Psychiatric Association, a seasonal pattern can exist with major depressive disorder or with major depressive episodes in bipolar I disorder (BID) or bipolar II disorder (BIID). (encyclopedia.com)
  • Although 60-90% of individuals with a seasonal component to their depressive disorder are women, it is currently unclear whether this reflects a gender factor specifically for SAD or merely reflects the underlying risks associated with recurrent major depressive disorder. (encyclopedia.com)
  • At this time, it is unknown whether a seasonal pattern is more likely in recurrent major depressive disorder or in bipolar disorders. (encyclopedia.com)
  • There are four criteria that must be met for a major depressive disorder, BID, or BIID to be characterized as seasonal. (encyclopedia.com)
  • Yerevanian BI, Anderson JL, Grota LJ, Bray M. Effects of bright incandescent light on seasonal and nonseasonal major depressive disorder. (harvard.edu)
  • Seasonal affective disorder or SAD is a recurrent major depressive disorder with a seasonal pattern usually beginning in fall and continuing into winter months. (hindawi.com)
  • Because this variable was found to be a high coefficient for discriminating chronic depressive patients, it could be an important tool in clinical practice to evaluate the stage and prognosis of major depressive disorder," said the researchers. (psychcentral.com)
  • Developments in the field of chronobiology and data obtained from chronotherapeutics may enable the development of evidence-based diagnosis and treatment in psychiatry. (balkanmedicaljournal.org)
  • Over the past few decades, chronobiology has developed into a multidisciplinary field of interest in general medicine and psychiatry (1). (balkanmedicaljournal.org)
  • Research into putative biological mechanisms of mental disorders has been of no value to clinical psychiatry. (cogprints.org)
  • The mainstream notion of disease in psychiatry, aiming to discover specific mental disorders and to demarcate normality from abnormality, may give an artificial impression of simple, detached things, rather than intricately connected factors and causes. (frontiersin.org)
  • Apart from the psychodynamic and the phenomenological-anthropological orientations, the history of psychiatry tells of many psychopathologists who saw close relations or a continuum through mental disorders and normality. (frontiersin.org)
  • This volume integrates concisely yet comprehensively advances in the diagnosis, management, and treatment of depressive disorders and bipolar disorders in infancy, childhood, and adolescence. (whsmith.co.uk)
  • Part III: Bipolar Disorders in Children and Adolescents. (whsmith.co.uk)
  • Bipolar disorders: natural history, genetic studies, and follow-up. (whsmith.co.uk)
  • Bipolar disorders: clinical manifestations, differential diagnosis, and treatment. (whsmith.co.uk)
  • Second, full remission of the depressive episodes (or a change from depression to mania or hypomania in the case of bipolar disorders) must also occur at predictable times of the year. (encyclopedia.com)
  • Recommendations from the International Society of Bipolar Disorders Task Force on Chronobiology and Chronotherapy and the Society for Light Treatment and Biologic Rhythms. (psychiatrictimes.com)
  • Hierarchical personality traits and the distinction between unipolar and bipolar disorders. (semanticscholar.org)
  • Frequently these disorders are comorbid with other psychiatric disorders. (whsmith.co.uk)
  • Understanding the genetic contribution of the Human Leukocyte Antigen system to common major psychiatric disorders in a world pandemic context. (medworm.com)
  • Consequently, this highly polymorphic gene region has recently emerged as a major player in the etiology of several major psychiatric disorders, such as schizophrenia, autism spectrum disorder and bi. (medworm.com)
  • Recent efforts to discover the genetics underlying natural variation in these physiological and behavioral processes may uncover how altered or disrupted rhythms may contribute to psychiatric disorders and other diseases. (technologynetworks.com)
  • Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. (springer.com)
  • It is estimated that 1-3 million children and adolescents in the United States alone suffer from depressive disorders. (whsmith.co.uk)
  • Part I: Clinical Manifestations of Depressive Disorders in Children and Adolescents. (whsmith.co.uk)
  • Epidemiology and etiology of depressive disorders. (whsmith.co.uk)
  • Part II: Diagnostic Assessment and Treatment of Depressive Disorders in Children and Adolescents. (whsmith.co.uk)
  • [5] Around 25% of patients with bipolar disorder may present with a depressive seasonal pattern, which is associated with bipolar II disorder, rapid cycling, eating disorders, and more depressive episodes. (wikipedia.org)
  • [13] Gender displays distinct clinical characteristics associated to seasonal pattern: males present with more Bipolar II disorder and a higher number of depressive episodes, and females with rapid cycling and eating disorders. (wikipedia.org)
  • Fatty acids in depressive and anxiety disorders. (nesda.nl)
  • Seasonality of symptoms in the general population and in patients with depressive and anxiety disorders. (nesda.nl)
  • Onset and recurrence of depressive disorders. (nesda.nl)
  • Heterogeneity in Major Depressive Disorders. (nesda.nl)
  • Burden of depressive disorders by country, sex, age, and year: Findings from the Global Burden of Disease Study 2010. (springer.com)
  • These variables may help differentiate between acute and chronic stages of depressive disorder. (psychcentral.com)
  • Animal models that mimic such rhythm disturbances are useful in translational research to explore factors contributing to depressive disorders. (bvsalud.org)
  • Bipolar disorder (BPD) is a widespread condition characterized by recurring states of mania and depression. (jcircadianrhythms.com)
  • Biologic rhythm disorders, depression, and phototherapy. (harvard.edu)
  • Seasonal affective disorder, or SAD, is a type of depression that occurs during the same season each year. (uwhealth.org)
  • They are also more prone to depression - a finding backed by extensive research on seasonal affective disorder (SAD), when some people grow depressed during the shorter winter days. (bluezones.com)
  • Those most at risk are female, are younger, live far from the equator, and have family histories of depression, bipolar disorder, or SAD. (hindawi.com)
  • According to the Diagnostic and Statistical Manual of Mental Disorders DSM-5 [ 1 ], criteria for depression with a seasonal pattern include having depression that begins and ends during a specific season every year (with full remittance during other seasons) for at least two years and having more seasons of depression than seasons without depression over a lifetime. (hindawi.com)
  • Ginzburg K, Ein-Dor T, Solomon Z. Comorbidity of posttraumatic stress disorder, anxiety and depression: A 20-year longitudinal study of war veterans. (springer.com)
  • Sartorius N, Üstün TB, Lecrubier Y, Wittchen H-U. Depression comorbid with anxiety: Results from the WHO study on psychological disorders in primary health care. (springer.com)
  • The purpose of the current investigation was to examine the personality predictors of bipolar disorder symptoms, conceptualized as one-dimensional (bipolarity) or two-dimensional (mania and depression). (semanticscholar.org)
  • Seasonal affective disorder (SAD) is characterized by recurrent episodes of depression in the fall and winter that alternate with nondepressed periods in the spring and summer. (internetandpsychiatry.com)
  • A handout on this topic is available at https://familydoctor.org/familydoctor/en/diseases-conditions/seasonal-affective-disorder.html . (aafp.org)
  • In a given year, about 5 percent of the U.S. population experiences seasonal affective disorder, with symptoms present for about 40 percent of the year. (aafp.org)
  • Bright light therapy is a common treatment for seasonal affective disorder and for circadian rhythm sleep disorders . (wikipedia.org)
  • Is short-wavelength (blue) light necessary for treatment of seasonal affective disorder? (harvard.edu)
  • Lux vs. wavelength in light treatment of Seasonal Affective Disorder. (harvard.edu)
  • Vasile RG, Sachs G, Anderson JL, Lafer B, Matthews E, Hill T. Changes in regional cerebral blood flow following light treatment for seasonal affective disorder: responders versus nonresponders. (harvard.edu)
  • Sleep in fall/winter seasonal affective disorder: effects of light and changing seasons. (harvard.edu)
  • As sunlight decreases during the short dark days of winter, many individuals struggle with seasonal affective disorder or SAD. (hindawi.com)
  • Seasonal affective disorder or SAD is not considered a unique diagnostic entity. (hindawi.com)
  • Journal of Affective Disorders. (springer.com)
  • BACKGROUND: Seasonal Affective Disorder (SAD) is supposed to be caused by lack of daylight in winter. (internetandpsychiatry.com)
  • Genes involved in serotonin metabolism are good candidates for the pathogenesis of seasonal affective disorder (SAD). (internetandpsychiatry.com)
  • As a result, such disruptions can lead to the development of physical or mental disorders (5). (balkanmedicaljournal.org)
  • 1 With strict application of criteria from the Diagnostic and Statistical Manual of Mental Disorders , 4th ed., text revision (DSM-IV-TR), 2 the prevalence of SAD is approximately 1 to 2 percent in the United States and approximately 2 percent in Canada. (aafp.org)
  • In the Diagnostic and Statistical Manual of Mental Disorders DSM-IV and DSM-5 , its status was changed. (wikipedia.org)
  • As noted earlier, the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ( DSM-5 ) has eliminated these delineations to further the understanding that most sleep disorders are complex interactions of behavior and biology. (medscape.com)
  • Many psychopathologists have approached symptom complexes without prejudging them as physical deficits or diseases, an approach suitable to connections with normal mind, to a broad dimensional and anthropological view of mental disorders. (frontiersin.org)
  • Examples of past unitary models of mental disorders with their neurophysiologic explanations are given, as well as an analogy to current biological aspects of the endogenous in chronobiology. (frontiersin.org)
  • The goal of the Medical Chronobiology Program at Brigham and Women's Hospital is to understand the biological basis behind these time-variant changes in disease severity. (harvard.edu)
  • This overlap is congruent with the observation that relatives of probands with schizophrenia are at higher risk for bipolar disorder and vice versa. (wikipedia.org)
  • Studies found modest associations between several genes that are known to be associated with the generation and regulation of circadian rhythms and bipolar disorder. (wikipedia.org)
  • Although no single gene causes the disorder, a number of genes are linked to increase risk of the disorder, and various gene environment interactions may play a role in predisposing individuals to developing bipolar disorder. (wikipedia.org)
  • Identification of susceptibility genes for bipolar disorder is the most direct way to discover the network of signaling pathways in the brain that regulate specific behaviors associated with the condition. (bipolarchild.com)
  • Chronobiology, says Amita Sehgal, "basically refers to the process by which organisms time physiology and behavior, so that everything takes place in a rhythmic fashion. (medicalxpress.com)
  • Although cases of SAD have been seen in children and adolescents, the disorder usually begins when one is in one's twenties. (encyclopedia.com)
  • The Sleep Disturbance Scale for Children (SDSC) is a 26-item parent questionnaire for children and adolescents to screen for primary sleep disorders such as obstructive sleep apnea. (medscape.com)
  • Pergolide (withdrawn from the US market on March 29, 2007) is effective in treating ADHD or Tourette syndrome and comorbid sleep disorder. (medscape.com)
  • Families of children with neurodevelopmental disorders are especially vulnerable during the COVID-19 pandemic. (medworm.com)
  • Development and plasticity of neuronal circuits and their pathology in neurodevelopmental disorders and neurodegeneration. (fsu.edu)
  • Two polymorphisms in the tryptophan hydroxylase 2 gene have been associated with bipolar disorder. (wikipedia.org)
  • Signaling pathways traditionally associated with bipolar disorder that have been supported by these studies include CRH signaling, cardiac β-adrenergic signaling, phospholipase C signaling, glutamate receptor signaling, cardiac hypertrophy signaling, Wnt signaling, notch signaling, and endothelin 1 signaling. (wikipedia.org)
  • CLOCK and ARNTL polymorphisms have also been associated with bipolar disorder, 2,3 antidepressant treatment response. (technologynetworks.com)
  • Aside from the required Pre-Veterinary courses, I tried to take as many interesting courses as I could, such as sleep and chronobiology, neuroendocrinology, mouse models of neuropsychiatric disorders, and the history of jazz music. (cornell.edu)
  • Establishing a molecular assay in humans for circadian rhythms from a single time point will allow us to identify circadian rhythm disorders, and to assess internal biological time to deliver therapies at their most efficacious time. (clinicaltrials.gov)
  • A number of lines of evidence suggests abnormalities in neurotransmission, intracellular signalling, and cellular functioning as possibly playing a role in bipolar disorder. (wikipedia.org)
  • Sleep study abnormalities in children with attention deficit hyperactivity disorder. (medscape.com)
  • Sleep disorders are better understood when subdivided into dyssomnias, which are characterized by abnormalities in the amount, quality, or timing of sleep, versus parasomnias, which are characterized by abnormal behavioral or physiologic events that occur in association with sleep stages or sleep-wake transitions. (medscape.com)
  • Hatfield TR, Brown RF, Giummarra MJ, Lenggenhager B. Autism spectrum disorder and interoception: Abnormalities in global integration? (springer.com)
  • Phenomenological predictors of psychosocial function in bipolar disorder: is there evidence that social cognitive and emotion regulation abnormalities contribute? (semanticscholar.org)
  • Criminal behavior as a clinical disorder. (cogprints.org)
  • A concluding section examines bipolar disorder -- its clinical manifestations, natural history, genetics, and treatment. (whsmith.co.uk)
  • To summarize the work to date, researchers supported by the Juvenile Bipolar Research Foundation (JBRF) has collected clinical information on a large sample of children who have been diagnosed or are suspected of having pediatric bipolar disorder. (bipolarchild.com)
  • Light therapy in the clinical management of an eating-disordered adolescent with winter exacerbation. (harvard.edu)
  • Blumer JL, Findling RL, Shih WJ, Soubrane C, Reed MD. Controlled clinical trial of zolpidem for the treatment of insomnia associated with attention-deficit/ hyperactivity disorder in children 6 to 17 years of age. (medscape.com)
  • Other laboratories at the University of Pennsylvania study related questions, such as the homeostatic regulation of sleep in mammalian and non-mammalian species, regulation of circadian rhythms, and clinical somatic and cognitive problems associated with the loss of sleep and sleep-disordered breathing. (upenn.edu)
  • Weitzman ED. Chronobiology of man: sleep, temperature and neuroendocrine rhythms. (springer.com)
  • Neuroendocrine chronobiology and reproductive neuroscience. (fsu.edu)
  • These mechanistic insights have led to the discovery of links between clock function and an ever-expanding array of prevalent diseases, including heart, lung, metabolic and sleep disorders. (clinicaltrials.gov)
  • There is no unquestionable scientific evidence, however, that major mental diseases or disorders are clearly divided from normal mind, or even divided among themselves. (frontiersin.org)
  • Alpha-2 receptor agonists for the treatment of posttraumatic stress disorder. (medscape.com)
  • The social zeitgeber hypothesis therefore proposes, that in bipolar disorder the fundamental circadian instability can be moderated by the stabilization of daily rhythms and zeitgeber. (wikipedia.org)
  • Both hypothesis are not yet fully proven but show the importance of sleep and sleep disruptions in bipolar disorder and the need for further research. (wikipedia.org)
  • Advanced paternal age has been linked to a somewhat increased chance of bipolar disorder in offspring, consistent with a hypothesis of increased new genetic mutations. (wikipedia.org)
  • To continue to focus on this single, hereditary behavior as the basis for future studies undoubtedly leaves some children who exhibit a bipolar disorder out of the mix. (bipolarchild.com)
  • In a technique called genome wide association study (GWAS), investigators scan the entire human DNA, or genome, of many individuals to pick up genetic variations that differ between healthy individuals and individuals with the disorder of interest. (bipolarchild.com)
  • Despite growing evidence of the impact that circadian dysfunction has on morbidity and mortality rates for numerous common medical illnesses, topics such as human circadian biology, circadian disorders, and chronobiology have received limited consideration in the medical school curriculum. (jcircadianrhythms.com)
  • Halberg, Pittendrigh, and their colleagues helped to lay much of the foundations of chronobiology, weaving together different strands of inquiry from biology, psychology, and genetics. (medicalxpress.com)
  • We are interested in neural mechanisms of cardiorespiratory disorders during sleep associated with a common disorder known as the Obstructive Sleep Apnea (OSA) Syndrome. (upenn.edu)
  • Research on chronobiology is constantly growing and has contributed to the development of an interdisciplinary field of research. (balkanmedicaljournal.org)
  • Minutes from prior meetings can be obtained, upon request, by contacting the National Center on Sleep Disorders Research . (nih.gov)
  • Further research will indicate what, if any, role circadian dysfunction plays in the pathogenesis of rapid-cycling bipolar disorder, and whether circadian interventions can be helpful to these often treatment-resistant patients. (scienceblogs.com)
  • The Columbia University Cardiopulmonary Sleep and Ventilatory Disorders Center is recognized as a major academic patient care, teaching, and research center of the Department of Medicine at the College of Physicians and Surgeons. (columbia.edu)
  • And almost without even trying to, the University of Pennsylvania has become one of the world's leading centers of chronobiology, with cutting-edge research that involves almost every one of Penn Medicine's science departments and several departments of its hospitals. (medicalxpress.com)
  • She also serves on the Editorial Boards of Chronobiology International, Journal of Neurology Research, and Journal of Sleep Disorders: Treatment and Care. (tawzerdog.com)
  • What is the role of medications in the treatment of pediatric sleep disorders? (medscape.com)
  • Delayed sleep phase disorder ( DSPD ), more often known as delayed sleep phase syndrome and also as delayed sleep-wake phase disorder , is a chronic dysregulation of a person's circadian rhythm (biological clock), compared to those of the general population and societal norms. (wikipedia.org)
  • People with the disorder who try to live on a normal schedule cannot fall asleep at a "reasonable" hour and have extreme difficulty waking because their biological clocks are not in phase with that schedule. (wikipedia.org)
  • The study of how biological clocks work to control and regulate almost every function of life is called chronobiology. (medicalxpress.com)
  • Still, chronobiology didn't begin to be recognized as a legitimate field of scientific study until around the 1960s, with the work of scientists such as Franz Halberg at the University of Minnesota, who coined the term "circadian" (meaning a 24-hour period), and Colin Pittendrigh at Princeton and Stanford, who organized the first dedicated scientific symposium on biological clocks at Cold Spring Harbor Laboratory in 1960. (medicalxpress.com)
  • Chronobiology is biological timing," says Amita Sehgal, Ph.D., professor of neuroscience and a Howard Hughes Medical Institute Investigator. (medicalxpress.com)
  • 87. Hovenkamp-Hermelink A. The long-term course of anxiety disorders: An epidemiological perspective Groningen University. (nesda.nl)
  • 62. Scholten, W. Waxing and waning of anxiety disorders: relapse and relapse prevention. (nesda.nl)
  • While it may be challenging to differentiate between OCD and other anxiety disorders, using a multi-informant assessment and understanding the content of a patient's fears is a fundamental start to outlining an effective treatment plan. (psychiatrictimes.com)
  • 9 Anticonvulsants and Calcium Antagonists in the Treatment of Psychotic Disorders. (bokus.com)
  • 4 Analysis of Fine Motor Problems in Children with Specific Developmental Disorders of Speech and Language. (bokus.com)
  • Journal of Autism and Developmental Disorders. (elsevier.com)
  • In evaluating a child or adolescent for a sleep disorder, the importance of a thorough sleep history cannot be overemphasized. (medscape.com)
  • Chronobiology is the study of biological rhythms. (balkanmedicaljournal.org)
  • Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and daily activity that often normalize after lithium treatment in responsive patients. (wiley.com)
  • The persistent rhythms of life, the body clocks that control when you wake, sleep, eat, digest food, and perform nearly every other function of a living organism, are all the province of chronobiology. (medicalxpress.com)