Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Melatonin: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.Mastectomy: Surgical procedure to remove one or both breasts.Mastodynia: Pain in the breast generally classified as cyclical (associated with menstrual periods), or noncyclical, i.e. originating from the breast or nearby muscles or joints, ranging from minor discomfort to severely incapacitating.Surgical Procedures, Minor: Surgery restricted to the management of minor problems and injuries; surgical procedures of relatively slight extent and not in itself hazardous to life. (Dorland, 28th ed & Stedman, 25th ed)Actigraphy: The measurement and recording of MOTOR ACTIVITY to assess rest/activity cycles.Breast Neoplasms: Tumors or cancer of the human BREAST.Body Temperature: The measure of the level of heat of a human or animal.Photoperiod: The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.Polysomnography: Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.Smith-Magenis Syndrome: Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.Cheek: The part of the face that is below the eye and to the side of the nose and mouth.Hearing Tests: Part of an ear examination that measures the ability of sound to reach the brain.Chromosomes, Human, Pair 17: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Syndrome: A characteristic symptom complex.Abnormalities, MultipleNatural History: A former branch of knowledge embracing the study, description, and classification of natural objects (as animals, plants, and minerals) and thus including the modern sciences of zoology, botany, and mineralogy insofar as they existed at that time. In the 17th, 18th, and 19th centuries it was much used for the generalized pursuit of certain areas of science. (Webster, 3d ed; from Dr. James H. Cassedy, NLM History of Medicine Division)Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)Chromosomes, Artificial, P1 Bacteriophage: DNA constructs that are derived from the DNA of BACTERIOPHAGE P1. They can carry large amounts (about 100-300 kilobases) of other sequence for a variety of bioengineering purposes.Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.Jet Lag Syndrome: A chronobiologic disorder resulting from rapid travel across a number of time zones, characterized by insomnia or hypersomnolence, fatigue, behavioral symptoms, headaches, and gastrointestinal disturbances. (From Cooper, Sleep, 1994, pp593-8)Miller Fisher Syndrome: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)Sleep Disorders, Circadian Rhythm: Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.Bell Palsy: A syndrome characterized by the acute onset of unilateral FACIAL PARALYSIS which progresses over a 2-5 day period. Weakness of the orbicularis oculi muscle and resulting incomplete eye closure may be associated with corneal injury. Pain behind the ear often precedes the onset of paralysis. This condition may be associated with HERPESVIRUS 1, HUMAN infection of the facial nerve. (Adams et al., Principles of Neurology, 6th ed, p1376)Arthrogryposis: Persistent flexure or contracture of a joint.Mitochondrial Myopathies: A group of muscle diseases associated with abnormal mitochondria function.De Quervain Disease: Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.Chronobiology Phenomena: Biological systems as affected by time. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Guillain-Barre Syndrome: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Environmental Health: The science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Serial Extraction: The selective extraction of deciduous teeth during the stage of mixed dentition in accordance with the shedding and eruption of the teeth. It is done over an extended period to allow autonomous adjustment to relieve crowding of the dental arches during the eruption of the lateral incisors, canines, and premolars, eventually involving the extraction of the first premolar teeth. (Dorland, 28th ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.NebraskaPsychology, Experimental: The branch of psychology which seeks to learn more about the fundamental causes of behavior by studying various psychologic phenomena in controlled experimental situations.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Sri LankaCarboxy-Lyases: Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.Smad3 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Smad4 Protein: A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.Smad7 Protein: An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Smad1 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.Osteonectin: Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Genetics, Medical: A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Policy: Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.Public Health Practice: The activities and endeavors of the public health services in a community on any level.Health Services Research: The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)Public Health Administration: Management of public health organizations or agencies.Research Support as Topic: Financial support of research activities.Patient Navigation: The process of helping patients to effectively and efficiently use the health care system when faced with one or more of these challenges: (1) choosing, understanding, and using health coverage or applying for assistance when uninsured; (2) choosing, using, and understanding different types of health providers and services; (3) making treatment decisions; and (4) managing care received by multiple providers.Nobel PrizeChronobiology Discipline: A multidisciplinary field of research and practice studying the periodicity of biological systems and the application of principles of chronobiology to various therapeutic strategies. Aging, biological rhythms, and cyclic phenomena are included. Statistical, computer-aided mathematical procedures are used to describe, in mathematical terminology, various biological functions over time.Chronotherapy: The adaptation of therapeutic approaches such as pharmacological (DRUG CHRONOTHERAPY), surgical, radiological, or physical to the known variations in biological RHYTHMICITY, such as CIRCADIAN RHYTHMS. The treatment is aimed at supporting normal rhythms, or modifying the timing of therapy to achieve maximal efficacy and minimal adverse effect.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.Circadian Clocks: Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.Chronobiology Disorders: Disruptions of the rhythmic cycle of bodily functions or activities.CLOCK Proteins: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.Interdisciplinary Studies: Programs of study which span the traditional boundaries of academic scholarship.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work. (1/96)

We tested the hypothesis that circadian adaptation to night work is best achieved by combining bright light during the night shift and scheduled sleep in darkness. Fifty-four subjects participated in a shift work simulation of 4 day and 3 night shifts followed by a 38-h constant routine (CR). Subjects received 2,500 lux (Bright Light) or 150 lux (Room Light) during night shifts and were scheduled to sleep (at home in darkened bedrooms) from 0800 to 1600 (Fixed Sleep) or ad libitum (Free Sleep). Dim light melatonin onset (DLMO) was measured before and after the night shifts. Both Fixed Sleep and Bright Light conditions significantly phase delayed DLMO. Treatments combined additively, with light leading to larger phase shifts. Free Sleep subjects who spontaneously adopted consistent sleep schedules adapted better than those who did not. Neither properly timed bright light nor fixed sleep schedules were consistently sufficient to shift the melatonin rhythm completely into the sleep episode. Scheduling of sleep/darkness should play a major role in prescriptions for overcoming shift work-related phase misalignment.  (+info)

beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome. (2/96)

Smith-Magenis syndrome (SMS) is a clinically recognisable contiguous gene syndrome ascribed to interstitial deletions of chromosome 17p11.2. Patients have a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Serum melatonin levels and day-night behaviour were studied in nine SMS children (aged 4 to 17 years) given acebutolol, a selective beta(1)-adrenergic antagonist (10 mg/kg early in the morning). Cardiac examination, serum melatonin, motor activity recordings, and sleep diaries were monitored before and after drug administration. The present study shows that a single morning dose of acebutolol suppressed the inappropriate secretion of melatonin in SMS. A significant improvement of inappropriate behaviour with increased concentration, delayed sleep onset, increased hours of sleep, and delayed waking were also noted. These results suggest that beta(1)-adrenergic antagonists help to manage hyperactivity, enhance cognitive performance, and reduce sleep disorders in SMS.  (+info)

Hypothalamic involvement in chronic migraine. (3/96)

OBJECTIVES: Chronic migraine (CM), previously called transformed migraine, is a frequent headache disorder that affects 2%-3% of the general population. Analgesic overuse, insomnia, depression, and anxiety are disorders that are often comorbid with CM. Hypothalamic dysfunction has been implicated in its pathogenesis, but it has never been studied in patients with CM. The aim was to analyze hypothalamic involvement in CM by measurement of melatonin, prolactin, growth hormone, and cortisol nocturnal secretion. METHODS: A total of 338 blood samples (13/patient) from 17 patients with CM and nine age and sex matched healthy volunteers were taken. Melatonin, prolactin, growth hormone, and cortisol concentrations were determined every hour for 12 hours. The presence of comorbid disorders was also evaluated. RESULTS: An abnormal pattern of hypothalamic hormonal secretion was found in CM. This included: (1) a decreased nocturnal prolactin peak, (2) increased cortisol concentrations, (3) a delayed nocturnal melatonin peak in patients with CM, and (4) lower melatonin concentrations in patients with CM with insomnia. Growth hormone secretion did not differ from controls. CONCLUSION: These results support hypothalamic involvement in CM, shown by a chronobiologic dysregulation, and a possible hyperdopaminergic state in patients with CM. Insomnia might be an important variable in the study findings.  (+info)

Heart rate and energy expenditure of incubating wandering albatrosses: basal levels, natural variation, and the effects of human disturbance. (4/96)

We studied the changes in heart rate (HR) associated with metabolic rate of incubating and resting adult wandering albatrosses (Diomedea exulans) on the Crozet Islands. Metabolic rates of resting albatrosses fitted with external HR recorders were measured in a metabolic chamber to calibrate the relationship between HR and oxygen consumption (V(O(2))) (V(O(2))=0.074 x HR+0.019, r(2)=0.567, P<0.001, where V(O(2)) is in ml kg(-1) min(-1) and HR is in beats min(-1)). Incubating albatrosses were then fitted with HR recorders to estimate energy expenditure of albatrosses within natural field conditions. We also examined the natural variation in HR and the effects of human disturbance on nesting birds by monitoring the changes in HR. Basal HR was positively related to the mass of the individual. The HR of incubating birds corresponded to a metabolic rate that was 1.5-fold (males) and 1.8-fold (females) lower than basal metabolic rate (BMR) measured in this and a previous study. The difference was probably attributable to birds being stressed while they were held in the metabolic chamber or wearing a mask. Thus, previous measurements of metabolic rate under basal conditions or for incubating wandering albatrosses are likely to be overestimates. Combining the relationship between HR and metabolic rate for both sexes, we estimate that wandering albatrosses expend 147 kJ kg(-1) day(-1) to incubate their eggs. In addition, the cost of incubation was assumed to vary because (i) HR was higher during the day than at night, and (ii) there was an effect of wind chill (<0 degrees C) on basal HR. The presence of humans in the vicinity of the nest or after a band control was shown to increase HR for extended periods (2-3 h), suggesting that energy expenditure was increased as a result of the disturbance. Lastly, males and females reacted differently to handling in terms of HR response: males reacted more strongly than females before handling, whereas females took longer to recover after being handled.  (+info)

Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. (5/96)

Mammalian free-running circadian rhythms are entrained to the external light/dark cycle by photic signaling to the suprachiasmatic nuclei via the retinohypothalamic tract (RHT). We investigated the circadian entrainment and clock properties of math5-/- mutant mice. math5 is a critical regulator of retinal ganglion cell development; math5-/- mice show severe optic nerve hypoplasia. By anterograde cholera toxin B tracing, we find that math5-/- mice do not develop an identifiable RHT pathway. This appears to be attributable to agenesis or dysgenesis of the majority of RHT-projecting retinal ganglion cells. math5-/- mice display free-running circadian rhythms with a period approximately 1 hr longer than B6/129 controls (24.43 +/- 0.10 vs 23.62 +/- 0.19 hr; p < 0.00001). The free-running period of heterozygote mice is indistinguishable from that of controls. math5-/- mice show no entrainment to light/dark cycles, whereas heterozygote mice show normal entrainment to both 12 hr light/dark cycles and to a 1 hr skeletal photoperiod. math5-/- mice show reduced ability to entrain their rhythms to the nonphotic time cue of restricted running wheel access but demonstrate both free-running behavior and entrained anticipation of wheel unlocking in these conditions, suggesting the presence of a second diurnal oscillatory system in math5-/- animals. These results demonstrate that retinal ganglion cell input is not necessary for the development of a free-running circadian timekeeping system in the suprachiasmatic nucleus but is important for both photic entrainment and determination of the free-running period.  (+info)

Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo. (6/96)

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse prognosis in cardiovascular diseases. We examined potential alterations in BPV and HRV in genetically dyslipidemic, apolipoprotein (apo) E-/-, and control mice and the effect of chronic statin treatment on these parameters in relation to their NO synthase (NOS)-modifying properties. METHODS AND RESULTS: BP and HR were recorded in unrestrained, nonanesthetized mice with implanted telemetry devices with or without rosuvastatin. Cardiac and aortic expression of endothelial NOS and caveolin-1 were measured by immunoblotting. Both systolic BP and HR were elevated in apoE-/- mice, with abolition of their circadian cycles. Spectral analysis showed an increase in their systolic BPV in the very-low-frequency (+17%) band and a decrease in HRV in the high-frequency (-57%) band, reflecting neurohumoral and autonomic dysfunction. Decreased sensitivity to acute injection of atropine or an NOS inhibitor indicated basal alterations in both parasympathetic and NOS regulatory systems in apoE-/- mice. Aortic caveolin-1 protein, an inhibitor of endothelial NOS, was also increased in these mice by 2.0-fold and correlated positively with systolic BPV in the very-low-frequency band. Rosuvastatin treatment corrected the hemodynamic and caveolin-1 expression changes despite persisting elevated plasma cholesterol levels. CONCLUSIONS: Rosuvastatin decreases caveolin-1 expression and promotes NOS function in apoE-/-, dyslipidemic mice in vivo, with concurrent improvements in BPV and HRV. This highlights the beneficial effects of rosuvastatin on cardiovascular function beyond those attributed to lipid lowering.  (+info)

An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. (7/96)

The suprachiasmatic nucleus (SCN) is the neuroanatomical locus of the mammalian circadian pacemaker. Here we demonstrate that an abrupt shift in the light/dark (LD) cycle disrupts the synchronous oscillation of circadian components in the rat SCN. The phases of the RNA cycles of the period genes Per1 and Per2 and the cryptochrome gene Cry1 shifted rapidly in the ventrolateral, photoreceptive region of the SCN, but were relatively slow to shift in the dorsomedial region. During the period of desynchrony, the animals displayed increased nighttime rest, the timing of which was inversely correlated with the expression of Per1 mRNA in the dorsomedial SCN. Molecular resynchrony required approximately 6 d after a 10 hr delay and 9 approximately 13 d after a 6 hr advance of the LD cycle and was accompanied by the reemergence of normal rest-activity patterns. This dissociation and slow resynchronization of endogenous oscillators within the SCN after an LD cycle shift suggests a mechanism for the physiological symptoms that constitute jet lag.  (+info)

Loss of circadian rhythm of blood pressure following acute stroke. (8/96)

BACKGROUND: Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator in patients with stroke in all communities. The risk of stroke is directly related to elevations of blood pressure. A number of clinical studies have shown that the control of hypertension leads to a reduction in the incidence of stroke in a community. However there is still considerable controversy surrounds the changes in blood pressure in various subtypes of strokes and problem of management of elevated BP after stroke. We studied the circadian rhythm of blood pressure in patients following acute stroke. METHODS: To study the circadian rhythm of blood pressure, fifty consecutive patients with an acute stroke who were admitted to medical emergency within 120 hours of onset were included in the study. After a detailed history and clinical examination, a continuous blood pressure monitor (Spacelab 90207) was attached on the side ipsilateral to intracranial lesion (unaffected arm). The blood pressure was recorded for 24 hours at 15 minutes interval during daytime (6.00 am-6.00 pm) and 20 minutes interval overnight (6 pm to 6 am). RESULTS: Risk factors for stroke in 50 patients included hypertension in 31(62%), diabetes mellitus in 4 (8%), smoking in 13 (26%) and previous history of transient ischemic attack in 7 (14%) patients. Mean systolic pressure and diastolic pressure at admission were higher in patients with hemorrhagic stroke -29 patients (177 +/- 24 mmHg and 105 +/- 19 mmHg respectively) compared to patients with ischemic strokes-21 patients (150 +/- 36 mm Hg and 89 +/- 18 mm Hg respectively, p value <0.01 in both comparisons). The normal diurnal variation in blood pressure (night time dipping of more than 10%) was abolished in 44 (88%) of patients. Out of 44 nondippers, 29 patients showed reverse dipping i.e. rise of BP during night time compared to day time levels. None of the risk factors, clinical or laboratory variables, type of stroke or blood pressure changes differed significantly between these two groups. CONCLUSIONS: Therefore, we showed a pathologically reduced or abolished circadian BP variation after stroke. Absence of normal dipping results in a higher 24 hour blood pressure load and may have more target organ damage than those with normal diurnal variation of blood pressure.  (+info)

*Phase response curve

Chronobiology Circadian rhythm sleep disorders Delayed sleep phase syndrome Carmen C. Canavier (2006). "Phase response curve". ... light therapy is used as treatment for several affective disorders including seasonal affective disorder (SAD). In 2002 Brown ... Various sleep disorders and externals stresses (such as jet lag) can interfere with this. People with non-24-hour sleep-wake ... Lewy A, Sack R, Fredrickson R (1983). "The use of bright light in the treatment of chronobiologic sleep and mood disorders: The ...

*Night owl (person)

Chronobiology Circadian rhythm sleep disorder Delayed sleep phase disorder Insomnia Lark (person) Morningness-eveningness ... Some night owls who have great difficulty adopting normal sleeping and waking times may have delayed sleep-phase disorder. ... Chronobiology (2004) Sleep Discrimination Intelligence and Creativity in Night Owls vs. Early Birds with several references to ... Seasonal Affective Disorder for Dummies (2007) p. 73 Jeff Belanger/Kirsten Dalley, The Nightmare Encyclopedia (2005) p. 83 ...

*Metabolic syndrome

... disrupted chronobiology/sleep, mood disorders/psychotropic medication use, and excessive alcohol use. There is debate regarding ... It has been found in Australia that 67% of patients with either bipolar disorder or schizoaffective disorder, and 51% of ... People with schizophrenia, schizoaffective disorder or bipolar disorder may have a predisposition to metabolic syndrome that is ... The syndrome is thought to be caused by an underlying disorder of energy utilization and storage. The cause of the syndrome is ...

*Delayed sleep phase disorder

Chronobiology Irregular sleep-wake rhythm Morningness-eveningness questionnaire Seasonal affective disorder (SAD) Sleep inertia ... 2007). "Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running ... There have been cases of DSPD developing into non-24-hour sleep-wake disorder, a severe and debilitating disorder in which the ... It has been named as one of the sleep disorders most commonly misdiagnosed as a primary psychiatric disorder. DSPD is often ...

*Biology of bipolar disorder

"The CLOCK gene and mood disorders: a case-control study and meta-analysis". Chronobiology international. 28 (9): 825-33. doi: ... Bipolar disorder is an affective disorder characterized by periods of elevated mood and depression. The cause and mechanism of ... Grunze, H. "Bipolar Disorder". In Zigmond, M; Rowland, L; Coyle, J. Neurobiology of Brain Disorder: Biological Basis of ... Although no single gene causes the disorder, a number of genes are linked to increase risk of the disorder, and various gene ...

*Circadian rhythm sleep disorder

... a circadian rhythm sleep disorder". Chronobiology International. 22 (3): 559-70. doi:10.1081/CBI-200062410. PMID 16076654. - " ... Advanced Sleep Phase Disorder, Delayed Sleep Phase Disorder, Free-Running Disorder, and Irregular Sleep-Wake Rhythm. PDF, 18 ... Circadian rhythm sleep disorders (CRSD) are a family of sleep disorders affecting (among other bodily processes) the timing of ... Non-24-hour sleep-wake disorder and other persistent circadian rhythm sleep disorders are believed to be caused by an ...

*Non-24-hour sleep-wake disorder

Chronobiology International. 19 (3): 649-658. doi:10.1081/CBI-120004546. PMID 12069043. "Experts compared, sleep tips, jet lag ... "Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, ... Delayed sleep phase disorder Advanced sleep phase disorder Irregular sleep-wake rhythm Circadian rhythm sleep disorder Seasonal ... Non-24-hour sleep-wake syndrome Non-24-hour sleep-wake disorder Non-24-hour sleep-wake rhythm disorder Free running disorder ( ...

*Seasonal affective disorder

"Chronotype And Personality Factors Of Predisposition To Seasonal Affective Disorder". Chronobiology International: the Journal ... With seasonal pattern is a specifier for bipolar and related disorders, including bipolar I disorder and bipolar II disorder. ... Seasonal affective disorder (SAD) is a mood disorder subset in which people who have normal mental health throughout most of ... Most people with SAD experience major depressive disorder, but as many as 20% may have a bipolar disorder. It is important to ...

*Suprachiasmatic nucleus

Chronobiology Photosensitive ganglion cell Sense of time Retinohypothalamic tract Shift work sleep disorder Fahey, Jonathan ( ... is reflected by several circadian rhythm sleep disorders, where this process does not function normally.[citation needed] ...

*Entrainment (chronobiology)

ASPD and non-24-hour sleep-wake disorder are improperly entrained to light/dark. Crepuscular - Animals active at twilight (i.e ... Entrainment, within the study of chronobiology, occurs when rhythmic physiological or behavioral events match their period to ... "Basic Science Review on Circadian Rhythm Biology and Circadian Sleep Disorders" (Review, Full Text, PDF). Annals Academy Med ...

*Light effects on circadian rhythm

Chronobiology Circadian advantage Circadian clock Circadian oscillator Circadian rhythm disorders Electronic media and sleep ... Seasonal affective disorder creates a model in which decreased day length during autumn and winter increases depressive ... Reviews in Endocrine and Metabolic Disorders. 10 (4): 301-310. doi:10.1007/s11154-009-9121-9. ISSN 1389-9155. Ma, W.P., J. Cao ... and depressive symptoms in this disorder. Light seems to have therapeutic antidepressant effects when an organism is exposed to ...

*List of cycles

Bipolar disorder - Cardiopulmonary resuscitation - Calvin-Benson cycle - Cell cycle - Chronobiology - Citric acid cycle - ...

*Morningness-eveningness questionnaire

Circadian rhythm sleep disorder Horne, JA, Östberg O (1976). "A self-assessment questionnaire to determine morningness- ... Chronobiology International. 28 (3): 238-247. doi:10.3109/07420528.2010.549599. PMC 3818690 . PMID 21452919. Hur YM, Bouchard ... eveningness in human circadian rhythms". International Journal of Chronobiology. 4 (2): 97-110. PMID 1027738. CS1 maint: ...

*Jürgen Aschoff

In: Trends in Chronobiology, ed. Hekkens W, Th JM, Jerkhof GA and Rhietveld WJ, Pergamon Press, Oxford and New York, pp. 149- ... His later work was more applicable to pathologies, such as psychiatric disorders and dangers of shift work schedules, which can ... Together with Erwin Bünning and Colin Pittendrigh, he is considered to be a co-founder of the field of chronobiology. Aschoff's ... Aschoff's work in the field of chronobiology introduced the idea that shifting one's light-dark cycle can result in harmful ...

*Thomas Wehr

Wehr and colleague Anna Wirz-Justice were awarded the Anna-Monika Prize for their work in the chronobiology of depressive ... Wehr and colleague Norman E. Rosenthal are credited with identifying and describing Seasonal Affective Disorder (SAD) and ... "Circadian Sleep Disorders," Nightline, February 21, 1996 "Body Clocks," The Infinite Mind, February 20, 2008 Science Magazine ...

*Zeitgeber

Seasonal affective disorder may occur as a result of deficiencies in zeitgebers (such as light) during the winter months that ... CHRONOBIOLOGY INTERNATIONAL, 17, 6, 719-732. Rutenfranz J, Helbruegge T. 1957. U ̈ ber Tageschwankungen der ... For bipolar disorder, Interpersonal and Social Rhythm Therapy (IPSRT) is meant to regulate and normalize an individual's social ... Howland, R. H., & Thase, M. E. (1999). Affective disorders: Biological aspects. In T. Millon, P. H. Blaney, & R. D. Davis (Eds ...

*Hiroki Ueda

In 2007 the Japanese Society for Chronobiology awarded him Young Investigator Promotion Award for a discovery of behavior of ... Innovator Award by Nikkei Business Publications for his invention on how to treat people with body time and rhythm disorders. ...

*NPAS2

Current research has revealed an association between seasonal affective disorder (SAD) and general mood disorder related to ... Chronobiology International. 32 (6): 785-91. doi:10.3109/07420528.2015.1049613. PMID 26134245. Soria V, Martínez-Amorós E, ... Associated with a connection to mood disorders, NPAS2 has been found to be involved with dopamine degradation. This was first ... and Npas2 are associated in an additive fashion with seasonal affective disorder or winter depression. Clock (gene) Bmal1/Arntl ...

*Circadian rhythm

A number of other disorders, for example bipolar disorder and some sleep disorders such as delayed sleep phase disorder (DSPD ... Johnson, Carl (2004). Chronobiology: Biological Timekeeping. Sunderland, Massachusetts, USA: Sinauer Associates, Inc. pp. 67- ... such as Advanced sleep phase disorder Delayed sleep phase disorder Non-24-hour sleep-wake disorder Circasemidian rhythm ... In medical science, an abnormal circadian rhythm in humans is known as circadian rhythm disorder. In 2017, the Nobel Prize in ...

*Eduard Estivill Sancho

In 1989, he created the Sleep Disorders Unit at the Institut Dexeus in Barcelona. Sancho is the author of numerous papers, more ... The standards recommended in this book are based on Chronobiology and behavioral pedagogical contributions, and are also based ...

*Bronowski Institute of Behavioural Neuroscience

Willis, G. L. (2008). "Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and ... Chronobiology International. 24 (3): 521-537. doi:10.1080/07420520701420717. PMID 17612949. ... that undertakes clinical and basic research into disorders of brain function and addresses problems of altered biological ...

*Seasonal effects on suicide rates

... bipolar disorder type II)". When a mood disorder recurs in a seasonal pattern it is described as a seasonal affective disorder ... Chronobiology International, 24, 727-737. Petridou E., Papadopoulos F. C., Frangakis C. E., Skalkidou A., Trichopoulos, D.. ( ... The seasonal mood disorders that were recurrent in this study are as follows: "depression, 51%, and bipolar disorder, 49%, with ... Psychological disorders can be affected by seasonal changes and result in suicide. There is also a "physiological strain that ...

*Sleep medicine

Chronic circadian rhythm disorders, the most common of which is delayed sleep phase disorder, may be managed by specifically- ... Due to the rapidly increasing knowledge about sleep, including the growth of the research field chronobiology from about 1960 ... The last two subgroups were (3) the medical or psychiatric sleep disorder section and (4) the proposed new disorders section. ... The International Classification of Sleep Disorders lists more than 80 different sleep disorder diagnoses. Sigurdson K; Ayas NT ...

*Fred W. Turek

He also served on the boards of the National Institute of Health National Center on Sleep Disorders Research and the National ... "Chronobiology" for the 2010 edition of Principles and Practices of Sleep Medicine. Turek has published nearly 400 reviews and ... aimed at shifting the human clock in an attempt to alleviate mental and physical problems that are associated with disorders in ...

*Charles Czeisler

As a Team Leader of the Human Performance Factors, Sleep and Chronobiology Team at the NASA National Space Biomedical Research ... CS1 maint: Uses authors parameter (link) "Sleep disorders linked to poor health and reduced occupational performance in police ... CS1 maint: Uses authors parameter (link) Münch M, Bromundt V (Dec 2012). "Light and chronobiology: implications for health and ... Awarded by the Society for Research on Biological Rhythms for his contributions to the field of Chronobiology in 2001 The NIOSH ...

*TIK-301

... is intended to be a take-as-need drug for primary insomnia, circadian rhythm disorders, depression, as well as sleep ... Chronobiology international. 19 (5): 915-36. doi:10.1081/cbi-120014108. PMID 12405554. Cardinali, DP; Srinivasan, V; Brzezinski ... In addition to a sleep aid, TIK-301 has been found useful in treating other disorders. Because of its affinity for serotonin ... TIK-301 has also been considered for use in patients with mild cognitive impairment (MCI) because of sleep disorder prevalence ...
Within the Life Safety Code, the NFPAs requirements for emergency lighting are referenced under section 7.9. Emergency illumination (when required) must be provided for a minimum of 1.5-hours in the event of failure of normal lighting. The emergency lighting must be arranged to provide initial illumination of not less than an average of one foot-candle and a minimum at any point of 0.1-foot-candle measured along the path of egress at floor level. And the emergency lighting system must be arranged to provide illumination automatically in the event of any interruption of normal lighting (section 7.9.2.3). ...
Although sleep and circadian rhythm disturbances are significant features of bipolar disorder and are associated with illness severity and recurrence, less is known about their significance prior to illness onset. Therefore, this study investigated these variables using objective assessment methods within a sample at high-risk of bipolar spectrum disorders. Thirty-one high-risk and 24 age- and gender-matched control participants wore an actigraph for 7 days to obtain sleep and circadian activity data. Self-report measures of mood, bed and get-up times, and cognitive style were also obtained. High-risk participants exhibited greater variability in duration, fragmentation, and efficiency of sleep, shorter sleep duration, and later and more variable bedtimes than controls. They also had lower relative amplitude of activity patterns and made more positive self-appraisals for hypomanic experiences. Logistic regression showed that positive self-appraisal and variability in bedtime significantly ...
Principal Investigator:UCHIYAMA Makoto, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Psychiatric science
Kirsten ten Tusscher first of all made a model that described the electrical behaviour of individual human heart muscle cells. She demonstrated that the behaviour of this model corresponded well with results from experiments on human heart cells. The source code of this cell model is freely available on Internet.. The researcher then used her new model to simulate the behaviour of 13,5 million individual grid points, which together form the anatomy of a human heart. As the model is extremely large and requires a considerable amount of calculating power, she used the TERAS supercomputer of SARA Computing and Networking Services and a mini-Beowulf cluster in her own Department of Theoretical Biology at Utrecht University. With this she studied the behaviour of electrical wave patterns during certain rhythm disorders in the human heart.. Heart rhythm disorders are abnormalities in the timing, sequence and co-ordination of how the heart muscle contracts. These vary in seriousness from palpitations ...
Clinical Presentation. The clinical presentation varies between patients and conditions, ranging from no symptoms to severe and frequently occurring symptoms 10. Though palpitations may occur infrequently, the typical symptoms are syncope (fainting) and cardiac arrest. Most inherited heart rhythm disorders are caused by autosomal dominant mutations 11-13. This means that a single genetic defect is present that results in the clinical condition that is inherited or transmitted to 50% of offspring. Typically, an index case (termed proband) presents with fainting, cardiac arrest or sudden death, and family screening identifies other members that are affected but with little or no symptoms. Being genetically affected, however, does not necessarily mean that individuals will be symptomatic. Penetrance is the term used to describe the proportion of individuals who possess the genetic mutation and are also symptomatic. The penetrance of inherited heart rhythm disorders is variable, ranging from 20-60% ...
How to Treat Heart Rhythm Disorders with Exercise. If you find out that you have a heart rhythm disorder, also known as an arrhythmia, it does not mean that you can never exercise again.http://www.heart.org/HEARTORG/Conditions/Arrhythmia...
There are eight reversible factors that can cause depression.. For some, depression may result from a combination of genetics, circadian rhythm disturbances, upbringing and social factors.. For others, depression may be rooted in a lack of dietary omega-3 fats combined with harmful addictions and adverse frontal lobe factors.. Exercise, herbs and nutrition play a role in the brains ability to manufacture serotonin and other neurotransmitters; thus, one may be able to manage good and bad stress, improve mood and change ones attitude and actions.. Dr. Neil Nedley, internal medicine specialist in cardiology, gastroenterology, and mental health and lifestyle medicine, has put together a DVD and eight-week depression recovery program.. This is being offered to Campbell River as a community service by Family Health and Education.. There are two free introductory sessions at 7 p.m. on Tues. Oct. 4 and Tues. Oct. 11. The eight-week program happens every Tuesday from 7-9 p.m. from Oct. 18 --Dec. 6, ...
The open and flexible UltraGATEWAY allows NightShift to build the routing and configuration of the data directly into their reporting and administration system. This makes it seamless to administer a scalable and growing radiology network, allowing simple modification and additions of doctors, customer sites and data centers in a constantly demanding environment. This partnership helps UltraRAD provide a better workflow driven solution for its customers and build a solid infrastructure for Nightshift ...
VELscope System uses blue spectrum lighting to screen for oral cancer. The VELscope® Oral Assessment System centers on a handheld scope that we use to screen for oral tissue abnormalities, including cancer. Unlike other adjunctive devices used for oral screening, the VELscope® does not require any dyes or prolonged testing procedures. In fact, a VELscope® exam is performed in our office during a routine hygiene exam (and under normal lighting conditions) in about two minutes. VELscope® technology is changing the way oral cancer screenings take place. The VELscope® handheld device emits a harmless, bright blue light which is used to inspect the mouth and tongue. The device is extremely sensitive to abnormal tissue changes and the distinctive blue-spectrum light causes the soft tissues of the mouth to naturally fluoresce. Healthy tissues fluoresce in distinct patterns that are visibly disrupted by trauma or disease, such as neoplastic lesions, and fungal, viral or bacterial infections. We use ...
The usefulness of QLF™ for the normal clinical practice lies, for some people, primarily in the realm of prevention and patient communication. Below an example of the use of QLF™ for the detection of cracks that are pretty hard, if not impossible, to detect with the naked eye under normal lighting conditions. See the QLF Library under Cracks. ...
Healthy people with Aβ buildup have irregular circadian rhythms. In mice, circadian disruptions dull daily Aβ oscillations and lead to more plaques.. ...
Healthy people with Aβ buildup have irregular circadian rhythms. In mice, circadian disruptions dull daily Aβ oscillations and lead to more plaques.. ...
When the human brain takes on intellectually challenging tasks, groups of neurons tune in to one another for a fraction of a second and harmonise, then go back to improvising, says a new study.
The underlying cause of any heart rhythm disorder provides the basis for selecting the best treatment plan. In general, the best treatment is the least invasive option that effectively controls the heart rhythm disorder. Treatment options fall into several categories from the least to the most invasive.
A method for quantifying cardiac desynchrony of the right and left ventricles includes obtaining cardiac acquisition data from a medical imaging system, and determining a movement profile from the cardiac acquisition data. The movement profile is directed toward identifying at least one of a time-based contraction parameter for a region of the left ventricle (LV), and a displacement-based contraction parameter for a region of the LV. The determined movement profile is visually displayed by generating a 3D model therefrom.
... ! Cordarone is used to treat a variety of different types of fast, abnormal heart rhythms (these are known as tachyarrhythmias). It is used for severe rhythm disorders when other treatments are not effective or cannot be used.
... ! Cordarone is used to treat a variety of different types of fast, abnormal heart rhythms (these are known as tachyarrhythmias). It is used for severe rhythm disorders when other treatments are not effective or cannot be used.
The human body functions according to a circadian rhythm thought to be controlled by a biological clock located in the part of the brain called the hypothalamus. There are several distinct disorders of our circadian rhythm and these are listed below: ...
The University Health Network (UHN) is excited to be hosting the 2018 Traumatic Brain Injury Conference an annual, one day event for healthcare practitioners, students, researchers, and community members who encounter traumatic brain injury in their practice. This event will explore topics such as concussion, long-term effects of brain injury, rehabilitation, and sleep/wake disturbances following brain injury from prominent researchers and renowned scholars.. February 2, 2018 ...
The University Health Network (UHN) is excited to be hosting the 2018 Traumatic Brain Injury Conference an annual, one day event for healthcare practitioners, students, researchers, and community members who encounter traumatic brain injury in their practice. This event will explore topics such as concussion, long-term effects of brain injury, rehabilitation, and sleep/wake disturbances following brain injury from prominent researchers and renowned scholars.. February 2, 2018 ...
Bright light therapy Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia Psychiatry Clin Neurosci 2000, 54, 352-3 Effects of phototherapy in patients with delayed sleep phase syndrome * Psychiatry Clin Neurosci 1999 Apr;53(2):231-3 Melatonin suppression by illumination of upper and lower visual fields * J Biol Rhythms. 1999 Apr;14(2):122-5…
history or DSISD (Duke Insomnia Sleep Diagnostics) suggests sleep disorder other than insomnia (e.g., sleep apnea, narcolepsy, periodic leg movements, etc.), or have insomnia associated with circadian rhythm disturbances, such as night or rotating shift work or travel across more than four time zones in the 14 days before Initial Screening (Visit 1) or during the study ...
Statement of Need Recent catastrophic bus and train accidents in the Bronx, New York, have highlighted the importance of understanding the negative effects of circadian sleep-wake disruption in shift workers, especially those in positions of responsibility for public safety, including bus and train operators and healthcare workers. Scientific evidence exists that manipulations by employers and employees can reduce the risk of errors due to sleep deprivation, so long as there is an understanding of underlying chronobiologic principles and the corresponding therapeutic options that can reduce and improve circadian disruption.. Activity Goal This program is designed to present the current understanding of chronobiology and the effects upon health and disease and to highlight the importance of circadian disruption on shift workers performances and productivity. Appropriate interventions can be undertaken by employers and employees to mitigate the effects of circadian disruption by manipulating ...
Introduction: Shift work, characterized by irregular schedules resulting in sleep loss and misalignment of circadian rhythms, is associated with increased incidence of cardiovascular disease. We tested whether circadian misalignment has an adverse impact on cardiovascular function independently of sleep loss. Methods: 19 healthy adults were studied using a parallel group design comparing two inter
Sleep duration and disruption have a significant impact on human health, quality of life, and life expectancy. Among humans, it is clear that the biological need for sleep varies dramatically. Natural short sleepers have a lifelong tendency to sleep only 4-5 h per night and to awaken refreshed and energetic. Natural long sleepers biologically require 9-10 h/night to feel well rested. The reason for these physiological differences is unknown and the genetic basis has not been explored.. Although relatively little is known regarding the genetic basis of sleep, there is a wealth of information on the genetics of circadian clock function across species. Sleep and circadian function are distinct processes that interact in living organisms. Although these two systems can operate independently, recent studies indicate a more intimate relationship.. Over the last decade, genetic material has been collected from individuals and families with circadian rhythm disturbances including familial advanced sleep ...
WASHINGTON - According to a new survey issued by the Heart Rhythm Society, the majority of Americans are unaware of two serious and potentially life-threatening heart rhythm disorders, atrial fibrillation (AF) and sudden cardiac arrest (SCA). In fact, only one in three Americans have ever heard of AF or recognize the number of lives claimed each year from SCA. Throughout February, Heart Health Month, the Heart Rhythm Society spotlights the need for public education on heart rhythm disorders affecting millions of people, and the specialists best suited to treat them - electrophysiologists.. More than 250,000 deaths occur each year as a result of SCA, more than breast cancer, lung cancer or AIDs. Yet, according to the recent survey, more than 65 percent of Americans not only underestimate the seriousness of SCA, but also believe SCA is a type of heart attack. While this current data does show a 5 percent increase since the Societys 2008 SCA awareness survey, the lack of awareness remains high and ...
Circadian clocks are found in nearly all organisms, from bacteria to mammals, and ensure that behavioral and physiological processes occur at optimal times of day and in the correct temporal order. It is becoming increasingly clear that chronic circadian misalignment (CCM), such as occurs in shift workers or as a result of aberrant sleeping and eating schedules common to modern society, has profound metabolic and cognitive consequences, but the proximate mechanisms connecting CCM with reduced organismal health are unknown. Furthermore, it has been difficult to disentangle whether the health effects are directly induced by misalignment or are secondary to the alterations in sleep and activity levels that commonly occur with CCM. Here, we investigated the consequences of CCM in the powerful model system of the fruit fly, Drosophila melanogaster. We subjected flies to daily 4-h phase delays in the light-dark schedule and used the Drosophila Activity Monitoring (DAM) system to continuously track locomotor
Behavioural signs and symptoms in dementia are of central clinical significance. There are a number of standardised rating scales available for the assessment of motor phenomena in dementia. However, there is no objective method of assessing these symptoms. In addition, the reliability of these scales, especially when used by caregivers from within families, has been questioned. In order to overcome this flaw, we propose the use of an actometric device for assessing behaviour motor symptoms in dementia. In the first part of this dissertation we assessed the reliability and the concurrent validity of an actometric device against two behavioural scales. Results show satisfactory validity and good reliability of this method. In the second part of this dissertation, we reanalysed data from our validation study, investigating whether the pattern of circadian rhythm disturbances is different in patients suffering from Alzheimer disease and patients suffering from vascular dementia, controlling ...
Causes of Arrhythmias (Heart Rhythm Disturbances) can depend on each individual situation. Learn about causes of Arrhythmias (Heart Rhythm Disturbances) and find symptoms, diagnosis, and many types of smart treatments for Arrhythmias (Heart Rhythm Disturbances) at FoundHealth.
FECYT - Spanish Foundation for Science and Technology. A possible pharmacology objective for chemotherapy. Patients receiving chemical treatment for cancer often suffer fatigue and body weight loss, two of the most worrying effects of this therapy linked to the alteration of their circadian rhythms.. The circadian system, better known as our biological clock, is responsible for coordinating all the processes that take place in our organism.. If it does not function correctly, what is known as a circadian disruption or chronodisruption, has for years been linked to an increased incidence of cancer, obesity, diabetes, depression, cognitive problems or cardiovascular diseases.. "Also, circadian disruption in cancer patients aggravates the prognosis of the disease and the chance of survival for these patients diminishes," Elisabet Ortiz Tudela, a researcher at the University of Murcia, told SINC.. The expert is the author of a study published in the International Journal of Cancer, which reveals ...
Heart rhythm disorders or heart rhythm disorders heart rhythm is irregular, sometimes fast (tachycardia) or slow or irregular (arrhythmia). At the heart rhythm disorder symptoms are generally mild without symptoms, so interference can only be known if you are feeling the pulse of the chest or the baby and found the irregular rhythm until hard to count how many times per minute her.. If this is the case does not mean there is no problem, precisely you should take him to the doctor to check and make sure his condition. As a precaution, you could be asked for recording an electrocardiogram (ECG) is used to determine the condition of his heart.. From the ECG recording, you can find out the childs heart condition in a normal state or there is interference. In severe heart rhythm disorders, the symptoms are a decrease in blood pressure, resulting in a pale, cold sweat and the body feels cold. Worse could seizures unconscious.. ...
Abstract:. BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P,0.03) than in the control group. No significant association was ...
obesity and mental illness. However, circadian disruptions are becoming increasingly widespread in our modern world. As such, there is an urgent need for novel technological solutions to address these issues.. In this talk, I will introduce the notion of "Circadian Computing" - technologies that support our innate biological rhythms. Specifically, I will describe a number of my recent projects in this area. First, I will present novel sensing and data-driven methods that can be used to assess sleep and related circadian disruptions. Next, I will explain how we can model and predict alertness, a key circadian process for cognitive performance. Third, I will describe a smartphone based tool for maintaining circadian stability in patients with bipolar disorder. To conclude, I will discuss a vision for how Circadian Computing can radically transform healthcare, including by augmenting performance, enabling preemptive care for mental health patients, and complementing current precision medicine ...
Sleep refreshes and restores us. However, when sleep is disrupted it can result in behavioral as well as physical problems that can seriously impact the ability of a child to perform optimally in school. This talk will provide participants with an overview of sleep and the problems that are associated with it. The highlights will include a number of the more common disturbances of sleep such as bedtime difficulties, night waking, circadian rhythm disorders and sleep terrors, and recent work on the nonmedical treatments for these problems. Described will be our work with children who have autism spectrum disorder who pose unique challenges and who exhibit a higher prevalence of sleep problems compared to the general population.. Review V. Mark Durands biographical statement.. ...
Generation of Knockout Mice. The methods for generation of the knockout mice were as described in detail by Roberts et al. (2000). In brief, gene inactivation was obtained by disruption of the first coding exon of the μ-opioid receptor gene in 129/SV embryonic stem cells. Germline transmission occurred from the breeding of chimeric males with C57BL/6Orl females. After mice were genotyped, those showing germline transmission were used as founder animals to produce the F1 animals used in these experiments. We used male homozygous MOR KO and WT littermate mice (shipped from Scripps Research Institute, La Jolla, CA) in these experiments. The genetic background of these mice was a hybrid C57BL/6Orl × 129/SV strain. We housed mice one to three per cage in a temperature-controlled room in which the lights were on a 12-h light/dark cycle with lights off at 10:00 AM.. In Vitro Single-Cell Recordings. We used 4- to 5-month-old MOR KO and genetically intact WT littermate mice in this study. In some ...
Background Maternal alcohol consumption is known to adversely affect fetal neurodevelopment. Cages and bedding, including access to environmental enrichment, were standardized between cages. Colonies were kept inside a controlled environment on a 14/10-h light/dark cycle at a heat of 21C to 24C with 40% to 60% moisture. Female mice of approximately 8 weeks of age were time-mated immediately with 8- to 12-week aged males. During gestation, dams were housed separately in standard cages. Six treatment occasions were selected to approximate ethanol publicity occurring in MK-0974 manufacture the human being 1st, second, and third trimesters: dam treatment at embryonic days (E) 8 and 11 (human being trimester one equivalent), E14 and 16 MK-0974 manufacture (human being second trimester equivalent), and pup treatment on postnatal days (P) 4 and 7 (human being third trimester equivalent) [19,25]. Each mouse (dam or pup) was treated on two treatment. To model punctuated high-blood alcohol (binge-like) ...
Induction of Diabetes. All procedures used in this study were approved by the animal care and use committee at Southern Illinois University, School of Medicine, and conformed according to National Institutes of Health and institutional guidelines. Mice were housed in standard cages and maintained on a 12-h light/dark cycle at an ambient temperature of 22 ± 1°C. Mice were housed in specific pathogen-free barrier animal facility, and rodent laboratory chow (Laboratory Diet 5001; Nutrition International, Inc., Brentwood, MO) and drinking water were provided ad libitum. Mice were at least 6 to 10 weeks of age and weighed between 18 and 23 g at the beginning of the experiments.. Age-matched single transgenic mice (Ins-HA.D2 mice), which express influenza hemagglutinin (HA) peptide, were used and were kindly provided by Dr. Lo (Lo et al., 1992). Freshly prepared STZ (50-200 mg/kg) in saline (pH 4.5 with 0.1 N citrate buffer) was injected intraperitoneally as described previously (Kamei et al., ...
Materials. Diclofenac sodium, CBZ, reserpine, and β-D-glucuronide glucuronosohydrolase (β-glucuronidase, EC 3.2.1.31) were purchased from Sigma-Aldrich (St. Louis, MO). D-SG, D-SNAC, 1-(2,6-dichlorophenyl)indolin-2-one, and D-1-O-G were synthesized as described below. All solvents used for HPLC and LC/MS were of chromatographic grade. Stock solutions of diclofenac (10 mM), D-SG (10 mM), D-1-O-G (1.3 mM), and D-SNAC (10 mM) were prepared as solutions in 50:50 acetonitrile/water (3% formic acid).. Animal Treatment. Male Sprague-Dawley rats (N = 2; 250 -275 g) were purchased from Charles River Breeding Laboratories (Portage, MI). Upon arrival, animals were acclimated following a 12-h light/dark cycle in a humidity- and temperature-controlled environment for 2 weeks in accordance with the National Institutes of Health publication Guide for the Care and Use of Laboratory Animals. After the first week of acclimation, surgically implanted venous and biliary catheters were placed into the superior ...
Tarfa M. P.*, Mshelia P. P., Mahdi O. and Leonard, M. P.. ABSTRACT. Randomly bred normal Forty (40) male albino rats of wistar strain obtained from the wistar rat colony of the Department of Pharmacology, University of Jos, were used for this study. All the animals weighing between 90 - 230 grams and 10 - 20 weeks old were maintained under uniform conditions across ventilated room (temperature 25 - 28oc, and 12h light/dark cycle), with free access to standard diet of Growers Mash (Vital Feed Nig PLC, Maiduguri) and portable water ad Libitum. The rats were divided into groups I, II, III and IV with 10 rats each. However, the rats in groups II, III and IV received oral administration of the solution of Methylene Chloride at 420mg/kg, 840mg/kg and 1260mg/kg respectively for 5 weeks via oro-gastric intubation. Routine histological sections of the testes obtained from rats treated with methylene chloride at all the dose levels (420mg/kg, 840mg/kg and 1260mg/kg) for 5 weeks were characterized by ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at Coliseum Health System Main Page Types of Arrhythmias Cause ...
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Drinking small amounts of alcohol frequently is linked with a higher likelihood of atrial fibrillation than binge drinking, according to research published today in EP Europace, a journal of the European Society of Cardiology (ESC).
The Council on Cardiac Pacing and Electrophysiology endeavors to provide continuing medical education for cardiologists and non-cardiologists on cardiac rhythm disorders, particularly on diagnosis, risk stratification and advances in management, the ultimate goal of which is to enhance the ability of non-electrophysiologists to care for and treat patients with cardiac rhythm disorders.. Chair 2014=2017: Erdie C. Fedriguilan, MD. Immediate Past Chair 2011-2014: Gladys Ruth S. David, ...
Circadian disruption has been implicated in tumour development, but the underlying mechanism remains unclear. Here, we show that the molecular clockwork within malignant human pancreatic epithelium is disrupted and that this disruption is mediated by miR-135b-induced BMAL1 repression. miR-135b directly targets the BMAL1 3-UTR and thereby disturbs the pancreatic oscillator, and the downregulation of miR-135b is essential for the realignment of the cellular clock. Asynchrony between miR-135b and BMAL1 expression impairs the local circadian gating control of tumour suppression and significantly promotes tumourigenesis and resistance to gemcitabine in pancreatic cancer (PC) cells, as demonstrated by bioinformatics analyses of public PC data sets and in vitro and in vivo functional studies ...
There were plenty of ooohs and ahhhs at Wellingtons Anzac dawn service today as Rawiri Phillips attended in a handmade soldier uniform his mum stayed up al
Our program offers comprehensive diagnosis and treatment of patients with heart rhythm disturbances and complex heart rhythm disorders
As part of a recent study, researchers tracked more than 10,000 middle-aged people for close to 14 years to understand the connection between microvascular disease and heart rhythm disorder.
Cardizem is a calcium channel blocker which is used to treat high blood pressure, chest pain, and certain heart rhythm disorders.
Tiazac (diltiazem) is used to treat high blood pressure, angina and certain heart rhythm disorders. Includes Tiazac side effects, interactions and indications.
Electrophysiology studies most often are recommended for patients with symptoms indicative of heart rhythm disorders or for people who may be at risk for sudden cardiac death.
... ! Calan is in a group of drugs called calcium channel blockers. Calan is used to treat hypertension, angina and certain heart rhythm disorders. It works by relaxing the muscles of your heart and blood vessels.
Betapace (Sotalol) is used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart ...
The Cardiac Arrhythmia Service is a group of health professionals dedicated to the diagnosis, assessment, management and education of patients who either have or are at risk of developing heart rhythm disorders.
A new blood thinner might be a viable alternative to warfarin (Coumadin), the standard for decades to treat patients with the dangerous heart rhythm disorder kn
My grumpy old lady and I are looking for a place to rent! I work for Coles and mostly do nightshift, and Roxy likes sleeping in high places and screaming at you when you go near her food bowl. Ideally Im looking for my own place but am willing to share with one other relatively clean woman. ...
MIL did something that upset me yesterday and Im not sure how to handle it. She kindly offered to mind DD for me while I had a nap with DS before my nightshift. I never asked where she was going or what she was doing with DD as previously
Purpose: Sirtuins are a family of NAD-dependent deacetylase that are involved in a variety of cellular functions including metabolism, DNA repair, apoptosis, neuronal survival and inflammation. However, much of the sirtuins in the retina are largely unknown. In this study, we analyzed the mRNA levels of seven sirtuins (Sirt1-7) together with the sirtuin-associated molecules, and the effect of light-dark condition on the expression levels in the retina.. Methods: Six-week-old male C57BL6/J mice were used. The mice were kept under 12-h light/12-h dark (LD) cycle. After keeping under the usual LD cycle for 2 weeks, the mice were randomly divided into the LD group and constant darkness group (DD group). The DD group was transferred to constant darkness after the dark phase of the last LD cycle, and kept in the dark for two 24-hours DD cycles, and then, sacrificed during third 24-hours DD cycle. The retina and the liver of the LD and DD group mice were sampled every 4 hours, and brain parietal ...
LA JOLLA, CA-Scientists have known for some time that throwing off the bodys circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.. Researchers at the Salk Institute for Biological Studies have now found a possible molecular link between circadian rhythm disturbances and an increased inflammatory response. In a study published July 9 in Proceedings of the National Academy of Sciences, the Salk team found that the absence of a key circadian clock component called cryptochrome (CRY) leads to the activation of a signaling system that elevates levels of inflammatory molecules in the body.. "There is compelling evidence that low-grade, constant inflammation could be the underlying cause of chronic diseases such as diabetes, obesity and cancer," says senior author Inder Verma, a professor in Salks Laboratory of Genetics and the Irwin and ...
Although sleep patterns change with age, it is the change in the ability to sleep that precipitates sleep complaints in older adults. Waking not rested, waking too early, trouble falling asleep, daytime napping, nocturnal waking, and difficulty initiating or maintaining sleep are among the chief sleep complaints of older adults. The consequences of poor sleep include difficulty sustaining attention, slowed response time, difficulty with memory, and decreased performance. Both medical and psychiatric conditions as well as the medications used to treat them lead to sleep complaints in older adults. Circadian rhythm disturbances and primary sleep disorders may also result in sleep complaints. Appropriate treatment may be dictated by severity of symptoms and concurrent medications. Efficacious pharmacologic interventions are the nonbenzodiazepine hypnotics zolpidem, zaleplon, and eszopiclone. Two new agents, ramelteon, which was recently approved by the U.S. Food and Drug Administration for use in ...
Science & Technology, Life Sciences & Biomedicine, Biology, Physiology, Life Sciences & Biomedicine - Other Topics, BIOLOGY, PHYSIOLOGY, melatonin suppression, light, melanopsin, human, SHORT-WAVELENGTH LIGHT, RETINAL GANGLION-CELLS, CIRCADIAN RESPONSES, HIGH-SENSITIVITY, ACTION SPECTRUM, DIM LIGHT, NON-CONE, NON-ROD, MELANOPSIN, BRIGHT ...
To see a picture of this specimen under normal lighting conditions, return to the fossil section. Look for the same product number followed by an "N." To see other fluorescent material from this location, return to the main fluorescent page and select the link "To view specimen material from Florida ...
30 In the absence of light input to the clock, nonphotic time cues are obviously a potential therapeutic option to treat non-24-hour circadian rhythms disorder. in the blind. There are currently no therapeutic guidelines, but some preliminary research suggests that it may be beneficial for patients to try to maintain a regular 24-hour schedule. Klerman Inhibitors,research,lifescience,medical and colleagues92 showed that the circadian system of a blind man with a period of 24.1 h became entrained when he lived on a 23.8 h "day." AU aspects of his schedule were shifted simultaneously in this protocol including the sleep-wake cycle, meal times, activity, posture, and interaction with staff, precluding identification of the effective time signal, but collectively at least they were able to induce a phase advance. Other attempts to entrain circadian rhythms in blind people using a "potential complex "zeitgeber" including exercise (bicycle riding, 50 W over 15 mins), a strict social routine, a cold ...
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia). It has distinct meanings and causes. It can refer to the usual state preceding falling asleep, the condition of being in a drowsy state due to circadian rhythm disorders, or a symptom of other health problems. It can be accompanied by lethargy, weakness, and lack of mental agility. Somnolence is often viewed as a symptom rather than a disorder by itself. However, the concept of somnolence recurring at certain times for certain reasons constitutes various disorders, such as excessive daytime sleepiness, shift work sleep disorder, and others; and there are medical codes for somnolence as viewed as a disorder. Sleepiness can be dangerous when performing tasks that require constant concentration, such as driving a vehicle. When a person is sufficiently fatigued, microsleeps may be experienced. In individuals deprived of sleep, somnolence may ...
Female Sprague-Dawley rats (n = 12, Harlan Laboratories) 220-245 g at embryonic day (E)2 were allowed to acclimate to the animal facility for 2 d before experimental manipulation. The pregnant dams were individually housed in a sealed and vented cage (Sealed Space Plus, Techniplast). Animals were housed under standard laboratory conditions in a temperature 20°C ± 1, and relative humidity 60% controlled environment, with a normal 12 h light/dark cycle (lights on 7:00 A.M.-7:00 P.M.). Food and water were available ad libitum. All procedures were performed in accordance with University of Colorado Institutional Animal Care and Use Committee guidelines for the humane use of laboratory rats in biological research.. Dams were randomly assigned to either a treatment group receiving prenatal stress (n = 5) or to a control nonstressed group (n = 4). To avoid litter size confounds due to a high mortality rate in the animals receiving both stress and terbutaline, pregnant dams were exposed to a daily ...
Animals and Treatment. All procedures were conducted in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the National Institutes of Health. Tg2576 transgenic mice (male and female) expressing Swedish mutated form of human APP (APPswe) (Hsiao et al., 1996) were bred in-house. All animals were maintained on a 12:12-h light/dark cycle with unrestricted access to food and water until use. Twenty-eight mice of 9.5 to 10.5 months of age were treated with CHF5074 (375 ppm in the diet) or standard diet (controls) for 17 weeks. At week 17, animals were sacrificed by decapitation, and brains were rapidly removed and divided in the two hemispheres. One hemisphere was used for measurements of Aβ plaques, and the other hemisphere was used for extractable Aβ. Blood samples were collected in EDTA-coated tubes and centrifuged at 800g for 20 min to separate plasma. Plasma samples were divided into two aliquots of approximately 100 μl each, and they were stored ...
Exercise has many well-established benefits to physical and mental health (25-30). The intensity, duration, frequency, mode, volume, and progression of exercise to optimize the beneficial effects have been well characterized (26, 44, 45). However, the proper timing of exercise and its potential added benefit of improving circadian entrainment have not been investigated thoroughly. Disruption of circadian rhythms (e.g., by shift work, social jetlag, early-morning schedules) is associated with metabolic disorders, cardiovascular disease, and cancer (6-11). If exercise could reduce circadian disruption, then it may also improve the risk factors associated with this disruption.. A tenet of the mammalian circadian system is that it is differentially sensitive to stimuli given at different times of day. Therefore, it is likely that the response of the internal circadian rhythm to exercise depends on the time of day of exercise. We chose morning and evening exercise for 2 reasons. First, morning ...
Learn how light and circadian disruption could be messing with your hormones, and how to ensure your body and brain can stay in sync with day and night.
Learn more about Other Treatments for Arrhythmias (Heart Rhythm Disturbances) at Reston Hospital Center Main Page Types of Arrhythmias ...
For every 1,000 people in the study, extra 5.2 cases of A-fib were documented among those who work long hours during the last 10 years. This is a serious cause.
St. Davids HealthCare, along with Texas Cardiac Arrhythmia, hasdeveloped the Texas Cardiac Arrhythmia Institute (TCAI) at St. DavidsMedical Center in Austin.
We have emailed you at with instructions on how to set up a new password. If you do not receive an email in the next 24 hours, or if you misplace your new password, please contact:. ASA members: ...
I was entranced by an essay in Emergency Physicians Monthly . . . If you want to know what professional craftsmanship looks like, this is it. ". -David Brooks, New York Times Op/Ed Editor. ...
... refers to the treatment used to restore normal heart rhythm in patients with heart rhythm disturbance. It is often recommended to patients with atrial fibrillation, a common heart rhythm disorder
Related Media: Understanding Atrial FibrillationArrhythmias That Start in the AtriaSinus Arrhythmia -Cyclic changes in the heart rate during...
The Heart Rhythm Society (HRS) is a leading resource on cardiac pacing and electrophysiology. This specialty organization represents medical, allied health, and science professionals from more than 70 countries who specialize in cardiac rhythm disorders.
The Heart Rhythm Society (HRS) is a leading resource on cardiac pacing and electrophysiology.This specialty organization represents medical, allied health, and science professionals from more than 70 countries who specialize in cardiac rhythm disorders.
Buy Online Inderal la is a beta-adrenergic receptor blocker and is used to treat angina, hypertension and heart rhythm disorders. Without a doctor prescription.
Anaprilin is used to treat tremors, chest pains, hypertension (high blood pressure), heart rhythm disorders. Order online with delivery to EU, UK, US & AU.
Current Research and Scholarly Interests Dr. Narayan directs the Computational Arrhythmia Research Laboratory, whose goal is to define the mechanisms underlying complex human heart rhythm disorders, to develop bioengineering-focused solutions to improve therapy that will be tested in clinical trials. The laboratory has been funded continuously since 2001 by the National Institutes of Health, AHA and ACC, and interlinks a disease-focused group of clinicians, computational physicists, bioengineers and trialists. ...
Ebony Alston, MD is a cardiologist with MedStar Heart & Vascular Institute at MedStar Franklin Square Medical Center. Dr. Alston treats patients with coronary artery disease, heart rhythm disorders, high cholesterol, hypertension, and congestive heart failure. She has a particular interest Cardiology
Researchers have created a sensor-embedded, replica of the heart's outer wall that could be used to treat and monitor heart rhythm disorders such as atrial fibrillation.
People with kidney disease may be at a higher risk of developing the heart rhythm disorder known as atrial fibrillation. Learn more about this new study.
Sometimes a picture paints a thousand words - and thats definitely the case with this hilarious explanation of heart rhythm disorders. Never have heart complaints seemed like this much fun. If you have one of these (I have AF) youll know that sometimes a good laugh is exactly what you need...
At 3:00am, Friday morning, I was doing my grocery shopping. As I left the store, this confrontation was taking place. The young man in black is a store employee and is their "in-house" security at night. The kid in the white t-shirt is a local punk who has been banned from the store for multiple reasons, mostly involving theft. The lady is Maggie, the nightshift checker ...
Taken on my way home from a nightshift. Id been taking shots of a loch before sunrise but after the sun came up, the mist rose and I had to stop and try to shoot it. This is 3 lots of 3 portrait shots which were first edited in photomatix for tonal range then stitched together and toned down in elements. I dont enjoy over the top HDR landscapes but this one accurately reflects the scene I saw, with the possible exception of the sky which has that HDR yellow tinge I find hard to remove!
Three Pygmy Marmoset monkeys, including a tiny four-week-old baby, have been stolen from Symbio Wildlife Park in Helensburgh, south of Sydney.
Friends and supporters are rallying around a B.C. family whose four-week-old baby is facing months of cancer treatment after being diagnosed with a rare form of infant leukemia.
Treats malaria. Quinine was the first effective treatment for malaria. Quinine should not be used to treat or prevent nighttime leg cramps. Quinine has not been shown to be effective for this purpose, and may cause serious issues.
It helps if you know what to expect and herself - so it is very important to seek urgent assistance from your general practitioner mental health service or a hospital emergency department to ensure the I was a rebel until now. An Economic Depression Is Characterized By A Sharp Function Low Thyroid struggling with desperation and financial anorexia even though the solutions are right in front of me I dont really have regrets but maybe the depression and the alcoholism didnt need to interrupt my first marriage. Pfarrer kritisiert Evangelikale fr Umgang mit Israel.. Antidepressant Medications Anti-depressant Drugs Antidepressant Medications Anti-depressant Drugs Introduction. Low-Carb Vegan Diet Plan. History Channel on Secret Societies: Why Shakespeare wrote "Lets kill all the Circadian Rhythm Disturbances in Dementia a.. Method of Assessment for Postpartum Depression Specified. (Depression is classified as minor depression if you have fewer than five depression symptoms for at least 2 These ...
Learn basic information about some of the most common types of sleep disorders, including: snoring, insomnia, sleep apnea, parasomnias, restless legs syndrome, narcolepsy, jet lag, and circadian rhythm disorders.
Duration discrimination within the seconds-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits via dopaminergic-glutamatergic pathways. Besides interval timing, most (if not all) organisms exhibit circadian rhythms in physiological, metabolic and behavioral functions with periods close to 24 h. We have previously reported that both circadian disruption and desynchronization impaired interval timing in mice. In this work we studied the involvement of dopamine (DA) signaling in the interaction between circadian and interval timing. We report that daily injections of levodopa improved timing performance in the peak-interval procedure in C57BL/6 mice with circadian disruptions, suggesting that a daily increase of DA is necessary for an accurate performance in the timing task. Moreover, striatal DA levels measured by reverse-phase high-pressure liquid chromatography indicated a daily rhythm under light/dark conditions. This daily variation was affected by ...
Competence in sleep medicine requires an understanding of a myriad of very diverse disorders, many of which present with similar symptoms such as excessive daytime sleepiness, which, in the absence of volitional sleep deprivation, "is almost inevitably caused by an identifiable and treatable sleep disorder", such as sleep apnea, narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome, menstrual-related hypersomnia, idiopathic recurrent stupor, or circadian rhythm disturbances.[36] Another common complaint is insomnia, a set of symptoms which can have a great many different causes, physical and mental. Management in the varying situations differs greatly and cannot be undertaken without a correct diagnosis.[37]. Sleep dentistry (bruxism, snoring and sleep apnea), while not recognized as one of the nine dental specialties, qualifies for board-certification by the American Board of Dental Sleep Medicine (ABDSM). The resulting Diplomate status is recognized by the American Academy of Sleep ...
Melatonin is a hormone that is synthesised by the pineal gland in humans and produced in animals as well as plants. Although the effects of melatonin are complex and poorly understood, it plays a critical role in the regulation of the sleeping and waking cycle and other circadian rhythms. Melatonin has been studied as a possible treatment of circadian rhythm disorders and may be helpful in reducing sleep disturbances caused by jet lag. Melatonin works by triggering chemical receptors in the brain to encourage sleep. Melatonin is not recommended for people with allergies or sensitivity to any of the medications ingredients, or who have problems with the immune system, kidney or liver problems. Alcohol should be avoided while taking melatonin. Because melatonin affects sleep patterns, it may affect a persons driving or the ability to operate machinery. Melatonin is not recommended during pregnancy or while breastfeeding. Melatonin may also react with other medications and treatments, including ...
0081] To determine whether direct stimulation of efferent vagus nerve activity might suppress the systemic inflammatory response to endotoxin, adult male Lewis rats were subjected to bilateral cervical vagotomy, or a comparable sham surgical procedure in which the vagus nerve was isolated but not transected. Efferent vagus nerve activity was stimulated in vagotomized rats by application of constant voltage stimuli to the distal end of the divided vagus nerve 10 min before and again 10 min after the administration of a lethal LPS dose (15 mg/kg, i.v.). An animal model of endotoxic shock was utilized in these experiments. Adult male Lewis rats (280-300 g, Charles River Laboratories, Wilmington, Mass.) were housed at 22° C. on a 12 h light/dark cycle. All animal experiments were performed in accordance with the National Institute of Health Guidelines under the protocols approved by the Institutional Animal Care and Use Committee of North Shore University Hospital/New York University School of ...
Neurology: Chronobiology Differs Between Men and Women with Cluster Headache, Clinical Phenotype is organized by American Academy of Neurology (AAN) and will be held during Mar 14, 2017 - Mar 14, 2020.

Circadian Disturbances After Breast Cancer Surgery - Full Text View - ClinicalTrials.govCircadian Disturbances After Breast Cancer Surgery - Full Text View - ClinicalTrials.gov

Chronobiology Disorders. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. Nervous System Diseases. ... Circadian Rhythm Disorders Anxiety Breast Cancer Device: Wrist-Actigraph - Octagonal Basic Motionlogger, Ambulatory monitoring ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01171508?term=Breast+Cancer&lup_s=02%2F26%2F2013&lup_d=30

Natural History Study of Smith-Magenis Syndrome - Full Text View - ClinicalTrials.govNatural History Study of Smith-Magenis Syndrome - Full Text View - ClinicalTrials.gov

Chromosome Disorders. Disease. Pathologic Processes. Genetic Diseases, Inborn. Chronobiology Disorders. Nervous System Diseases ... and a striking neurobehavioral phenotype that includes a circadian sleep disorder. The majority of cases (~90%) are due to de ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00013559?cond=%22Smith-Magenis+syndrome%22&rank=1

Search  DefinitionsSearch Definitions

Chronobiology Disorders; Circadian Rhythm Sleep Disorders; Connective Tissue Diseases; De Quervain Disease; Dysautonomia; ... Key words: ALS; Amyotrophic Lateral Sclerosis; Arnold Chiari Syndrome; Arthrogryposis; Atrophic Muscular Disorders; Autonomic ... Spinal Disorders; Spondylitis; Spondylolisthesis; Tendinitis; Tennis Elbow; Tenosynovitis; Tietzes Syndrome; Tuberous Sclerosis ...
more infohttp://nccs.urban.org/sites/all/nccs-archive/html/PubApps/nteeSearch.php?returnElement=&popup=0&code=G50&codeType=NTEE

Treatment Strategies for Children With Smith-Magenis Syndrome - Full Text View - ClinicalTrials.govTreatment Strategies for Children With Smith-Magenis Syndrome - Full Text View - ClinicalTrials.gov

Mental Disorders. Neurobehavioral Manifestations. Neurodevelopmental Disorders. Behavioral Symptoms. Chronobiology Disorders. ... Developmental Delay Disorders Chromosome Deletion Mental Retardation Sleep Disorders, Circadian Rhythm Self Injurious Behavior ... Sleep Wake Disorders. Parasomnias. Intellectual Disability. Self-Injurious Behavior. Smith-Magenis Syndrome. Sleep Disorders, ... Individuals who have been diagnosed with a sleep disorder (e.g, restless legs, sleep apnea) known to impact sleep may be ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00506259

Books - Medicine - Terkko NavigatorBooks - Medicine - Terkko Navigator

Circadian rhythms : biology, cognition and disorders. Circadian rhythms, Chronobiology Disorders, Circadian Rhythm, sähkökirjat ... Platelets, Blood Platelets, Blood Platelet Disorders, Blood platelets, sähkökirjat, Blood platelet disorders ...
more infohttps://www.terkko.helsinki.fi/anatomy-and-physiology/books

RePub, Erasmus University Repository:
  The significance of circadian rhythms and dysrhythmias in critical illnessRePub, Erasmus University Repository: The significance of circadian rhythms and dysrhythmias in critical illness

biological clocks, Chronobiology disorders, circadian rhythms, critical illness, physiology Persistent URL. dx.doi.org/10.1177/ ...
more infohttps://repub.eur.nl/pub/99769

Visual impairment and circadian rhythm disorders.  - Surrey Research Insight Open AccessVisual impairment and circadian rhythm disorders. - Surrey Research Insight Open Access

Animals, Central Nervous System Depressants, Chronobiology Disorders, Humans, Melatonin, Vision Disorders Related URLs :. * ... Lockley, SW, Arendt, J and Skene, DJ (2007) Visual impairment and circadian rhythm disorders. Dialogues Clin Neurosci, 9 (3). ...
more infohttp://epubs.surrey.ac.uk/207043/

SelfDecode | Genome AnalysisSelfDecode | Genome Analysis

Chronobiology Disorders AHR,PPARG. Hyperglycemia PRKCB,SP1. Waardenburg Syndrome Type 2 MITF,SOX10. ...
more infohttps://www.selfdecode.com/molecular-function/GO:0006357/

Northwestern University - Research Output
     - Northwestern ScholarsNorthwestern University - Research Output - Northwestern Scholars

Clinical neurophysiology of circadian rhythm sleep-wake disorders. Saeed, Y., Zee, P. C. & Abbott, S. M., Jan 1 2019, Handbook ... Endocrine Disorders. Eustler, EP. & Shore, RM., 2019, Caffeys Pediatric Diagnostic Imaging, 13th ed.. Coley, BD. (ed.). ... Fertility preservation in patients with disorders of sex development. Chen, D., Johnson, EK. & Finlayson, C., 2019, Textbook of ... Fertility Preservation in Patients with Disorders of Sex Development. Finlayson, CA., Chen, D. & Johnson, EK., 2019, ...
more infohttps://www.scholars.northwestern.edu/en/organisations/northwestern-university/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontobookanthology%2Fchapter

Brett R Kuhn, PhD - Research Output
     - Research NebraskaBrett R Kuhn, PhD - Research Output - Research Nebraska

Sanberg, S. A., Kuhn, B. R. & Kennedy, A. E., Dec 1 2018, In : Journal of Autism and Developmental Disorders. 48, 12, p. 4250- ... Maternal report of attention deficit hyperactivity disorder symptoms in preschool children. Gimpel, G. A. & Kuhn, B. R., Dec 1 ... Outcomes of a Behavioral Intervention for Sleep Disturbances in Children with Autism Spectrum Disorder. ...
more infohttps://nebraska.pure.elsevier.com/en/persons/brett-r-kuhn/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

SelfDecode | Genome AnalysisSelfDecode | Genome Analysis

Chronobiology Disorders PPARG. Ciliary Dyskinesia, Primary, 7 DNAH11. Ciliary Motility Disorders IFT122. ...
more infohttps://www.selfdecode.com/molecular-function/GO:0007507/

Need to  get some answers. - lookformedical.comNeed to get some answers. - lookformedical.com

Chronobiology Disorders (0) * Cranial Nerve Diseases (3) * Demyelinating Diseases (0) * Nervous System Malformations (0) ...
more infohttps://lookformedical.com/answers/en/3057/need-to-get-some-answers

No questions in Sturge-Weber Syndrome - lookformedical.comNo questions in Sturge-Weber Syndrome - lookformedical.com

Chronobiology Disorders (0) * Cranial Nerve Diseases (3) * Demyelinating Diseases (0) * Nervous System Malformations (1) ...
more infohttps://lookformedical.com/answers/en/diseases/nervous-system-diseases/neurocutaneous-syndromes/sturge-weber-syndrome

Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders - Balkan Medical...Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders - Balkan Medical...

Chronobiology. Horm Res 1990;33:53-7. 2. Monteleone P, Maj M. The circadian basis of mood disorders: recent developments and ... Wirz-Justice A. Chronobiology and mood disorders. Dialogues Clin Neurosci 2003;5:315-25. 26. Wirz-Justice A. Circadian rhythms ... Translational research in chronobiology can provide insights into the diagnostic and therapeutic processes of mood disorders in ... Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders ...
more infohttp://balkanmedicaljournal.org/text.php?lang=en&id=1915

Wiley Online Library: Search Results PageWiley Online Library: Search Results Page

Chronobiology of mood disorders. Acta Psychiatrica Scandinavica. Volume 128, Issue s444, September 2013, Pages: 2-15, G. S. ... Is it Trauma- or Fantasy-based? Comparing dissociative identity disorder, post-traumatic stress disorder, simulators, and ... Lithiums role in neural plasticity and its implications for mood disorders. Acta Psychiatrica Scandinavica. Volume 128, Issue ... Use of psychotropic drugs in patients with autism spectrum disorders: a systematic review. Acta Psychiatrica Scandinavica. ...
more infohttp://onlinelibrary.wiley.com/advanced/search/results?articleDoi=10.1111/acps.12085&scope=allContent&start=1&resultsPerPage=20

Melatonin, Neuroprotective Agents and Antidepressant Therapy | SpringerLinkMelatonin, Neuroprotective Agents and Antidepressant Therapy | SpringerLink

Chronobiology of Mood Disorders Felice Iasevoli, Livia Avvisati, Valentina Gilardi, Gianmarco Latte, Emiliano Prinzivalli, ... Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the ... Agomelatine Chronobiology of mood disorders Hippocampal neurogenesis, depression and antidepressants Melatonergic drugs in ... Sleep Abnormalities as a Diagnostic Tool for Major Depressive Disorder Alan B. Douglass, Marcus Ward, Timothy Roerhrs, Cynthia ...
more infohttps://link.springer.com/book/10.1007/978-81-322-2803-5

The Influence of Air Travel on Athletic Performance | SpringerLinkThe Influence of Air Travel on Athletic Performance | SpringerLink

Chronobiology and psychiatric disorders. New York: Elsevier Science Publishing Co., 1987: 241-62Google Scholar ... Chronobiology of man: sleep, temperature and neuroendocrine rhythms. Hum Neurobiol 1982; 1: 173-83PubMedGoogle Scholar ... Chronobiology: principles and applications to shifts in schedules. Rockville (MD): Sijthoff & Noordhoff, 1980: 417-31Google ...
more infohttps://link.springer.com/article/10.2165/00007256-199928030-00004

Neuropsychopharmacology - 5th Generation of Progress - ACNPNeuropsychopharmacology - 5th Generation of Progress - ACNP

... movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in ... Nine sections focus on specific groups of disorders-disorders of development; schizophrenia and related disorders; anxiety and ... affective disorders; Alzheimers and other dementias; substance use disorders; impulsive and compulsive disorders; ... Chapter 42: Current And Emerging Therapeutics Of Autistic Disorder And Related Pervasive Developmental Disorders (PDF) ...
more infohttps://acnp.org/digital-library/neuropsychopharmacology-5th-generation-progress/

Le parole che non ti ho detto. Semantica dellaffettività.   - CogprintsLe parole che non ti ho detto. Semantica dell'affettività. - Cogprints

Chronobiology and mood disorders. «Dialogues in Clinical Neuroscience», 2003;5:315-325. ... Journal of Affective Disorders», 2005;85:231-239; H.S. Akiskal, K. Akiskal, J.F. Allilaire, J.M. Azorin, M.L. Bourgeois, D. ... Journal of Affective Disorders», 2004;81:91-102. Z. Kronfol, D.G. Remick. Cytokines and the brain: implications for clinical ... Mood disorders in stroke patients: importance of location of lesion. «Brain», 1984;107:81-93; S.E. Starkstein, R.G. Robinson, T ...
more infohttp://cogprints.org/9046/index.html

Research Interests for Richard S. KeefeResearch Interests for Richard S. Keefe

Chronobiology Disorders, Clinical Trials as Topic, Clozapine, Cognition, Cognition Disorders, Cohort Studies, Communication, ... Memory Disorders, Mental Processes, Middle Aged, Mild Cognitive Impairment, Mood Disorders, Motivation, Movement Disorders, ... Psychotic Disorders, Pyrimidines, Quality of Life, Questionnaires, Quinolones, Randomized Controlled Trials as Topic, Reaction ... Sensation Disorders, Severity of Illness Index, Sex Characteristics, Social Adjustment, Social Behavior, Socioeconomic Factors ...
more infohttp://fds.duke.edu/db/aas/pn/faculty/richard.keefe/research.html

ScopeMed.org - Deposit for Medical ArticlesScopeMed.org - Deposit for Medical Articles

Chronobiology and Mood Disorders. Yavuz Selvi, L tfullah Be iro lu, Adem Ayd n. Psikiyatride Guncel Yaklasimlar - Current ... Organic personality disorder after aneurysm surgery: a case report. P nar G zel zdemir, Yavuz Selvi, Adem Ayd n. D nen Adam: ... Journal of Mood Disorders. 2011; 1(4): 169-177.. *Giant Mature Adrenal Cystic Teratoma in an Infant. Ilhan Ciftci, Tugba Cihan ... Journal of Mood Disorders. 2011; 1(4): 152-161.. * In vitro cytogenetic effects of moxifloxacin Lale Donbak; Ahmet Kayraldiz; ...
more infohttp://www.scopemed.org/?term=Yavuz%20Tokgoz&sarea=author&b1=Search+ScopeMed

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithiumGlycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

Chronobiology and psychiatric disorders. New York:Elsevier, pp. 263-289. * Manji, HK and Lenox, RH (2000). The nature of ... Lenox, HL, Gould, TD and Manji, HK (2002). Endophenotypes in bipolar disorder. Am J Med Genet 114: 391-406, [PubMed] DOI: https ... Bipolar disorder is a common, chronic, severe, and often life-threatening illness, characterized by recurrent episodes of two ... Background: Bipolar disorder (BPD) is a widespread condition characterized by recurring states of mania and depression. Lithium ...
more infohttps://www.jcircadianrhythms.com/articles/10.1186/1740-3391-5-3/

ScopeMed.org - Deposit for Medical ArticlesScopeMed.org - Deposit for Medical Articles

Chronobiology and Mood Disorders. Yavuz Selvi, L tfullah Be iro lu, Adem Ayd n. Psikiyatride Guncel Yaklasimlar - Current ... Journal of Mood Disorders. 2011; 1(4): 169-177.. *The relationship between insomnia and major depressive disorder: a chicken ... Journal of Mood Disorders. 2013; 3(1): 1-7.. *Surgical approach and problems in limb salvage after a pig bite. Adem G ler1, ... Organic personality disorder after aneurysm surgery: a case report. P nar G zel zdemir, Yavuz Selvi, Adem Ayd n. D nen Adam: ...
more infohttp://www.scopemed.org/?term=Adem%20Sezen&sarea=author&b1=Search+ScopeMed
  • SBRI research is a multidisciplinary with interests ranging from stem cells biology, developmental neurobiology , integrative and cognitive neuroscience , chronobiology disorders and robotics . (sbri.fr)
  • To describe the physiologic and behavioral characteristics of circadian rhythm sleep disorders (CRSDs) following minor traumatic brain injury (mTBI) in patients complaining of insomnia. (labome.org)
  • Developments in the field of chronobiology and data obtained from chronotherapeutics may enable the development of evidence-based diagnosis and treatment in psychiatry. (balkanmedicaljournal.org)
  • b>Circadian rhythm sleep disorders are common conditions manifested as misalignment between the sleep period and the physical/social 24-h environmental cycle. (labome.org)