Chromosome Inversion
Chromosomes
Partial monosomy and partial trisomy 18 in two offspring of carrier of pericentric inversion of chromosome 18. (1/1042)
A pericentric inversion of chromosome 18 is described in the mother of a patient with clinical diagnosis of 18q--syndrome. The propositus' chromosome complement includes the recombinant 18 with deficiency of the distal one-third of the long arm and duplication of the terminal segment of the short arm. The propositus' sister carrier the recombinant 18 with a duplication of the distal one-third of the long arm and a deficiency of the terminal segment of the short arm. The relative length of the inverted segment represents about 60% of the total chromosome 18 length. The probability of recombinant formation following the occurrence of a chiasma within the inverted segment is predicted to be high. (+info)Modification of non-conservative double-strand break (DSB) rejoining activity after the induction of cisplatin resistance in human tumour cells. (2/1042)
The induction of collateral radioresistance after the development of cisplatin resistance is a well-documented phenomenon; however, the exact processes that are responsible for the cisplatin-induced radioresistance remain to be elucidated. There was no obvious difference in the level of radiation-induced DNA double strand breaks (DSBs), in DSB rejoining rates, or the level of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) in the cisplatin- and radiation-sensitive 2780/WT and cisplatin-resistant 2780/CP cell lines. However, there was a significantly (P < 0.01) lower level of DSB misrejoining activity within nuclear protein extracts derived from the cisplatin- and radiation-sensitive 2780/WT and OAW42/WT tumour cell lines than in similar extracts from their cisplatin- (and radiation-) resistant 2780/CP and OAW42/CP counterparts. All of the DSB misrejoining events involved deletions of between 134 and 444 bp that arose through illegitimate recombination at short repetitive sequences, such as those that arise through non-homologous repair (NHR). These data further support the notion that the radiosensitivity of DSB repair proficient human tumour cell lines may be partly determined by the predisposition of these cell lines to activate non-conservative DSB rejoining pathways. Furthermore, our data suggest that the induction of acquired cisplatin resistance is associated with a two- to threefold decrease in the activity of a non-conservative DSB rejoining mechanism that appears to be a manifestation of NHR. (+info)Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (3/1042)
The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes. (+info)Multiple DNA binding activities of the novel site-specific recombinase, Piv, from Moraxella lacunata. (4/1042)
The recombinase, Piv, is essential for site-specific DNA inversion of the type IV pilin DNA segment in Moraxella lacunata and Moraxella bovis. Piv shows significant homology with the transposases of the IS110/IS492 family of insertion elements, but, surprisingly, Piv contains none of the conserved amino acid motifs of the lambda Int or Hin/Res families of site-specific recombinases. Therefore, Piv may mediate site-specific recombination by a novel mechanism. To begin to determine how Piv may assemble a synaptic nucleoprotein structure for DNA cleavage and strand exchange, we have characterized the interaction of Piv with the DNA inversion region of M. lacunata. Gel shift and nuclease/chemical protection assays, competition and dissociation rate analyses, and cooperativity studies indicate that Piv binds two distinct recognition sequences. One recognition sequence, found at multiple sites within and outside of the invertible segment, is bound by Piv protomers with high affinity. The second recognition sequence is located at the recombination cross-over sites at the ends of the invertible element; Piv interacts with this sequence as an oligomer with apparent low affinity. A model is proposed for the role of the different Piv binding sites of the M. lacunata inversion region in the formation of an active synaptosome. (+info)The frequency and allelism of lethal chromosomes in isolated desert populations of Drosophila pseudoobscura. (5/1042)
Second-chromosome lethals were extracted from four populations of Drosophila pseudoobscura in Southern California. Two of the populations were from desert oases and two from the classic habitat on Mt. San Jacinto, previously studied by Dobzhansky. Allelism tests were made on the lethals within and between all locations. The frequency of lethal second-chromosomes in each location was 0.18, and this was not different from the results of other workers for samples throughout the species range. Interpopulational allelism rates were about 0.005, and not different from earlier results of Dobzhansky. Intrapopulational rates in this study were, with one exception, the same as the interpopulational rates, and significantly lower than Dobzhansky found using the third chromosome. This may be due to lethals being linked with heterotic third-chromosome inversions. The allelism rate of the exceptional population (about 0.03 and equal to Dobzhansky's intrapopulational results) may be due to heterotic lethals, or a founder effect. Two lethals were found in three populations each, possibly due to migration among these populations, which are up to 334 km apart. (+info)Gene differences between third-chromosome inversions of Drosophila pseudobscura. (6/1042)
Associations of alleles of the acid phosphatase-3 locus with the different third-chromosome inversions from different populations of D. pseudoobscura are described. We observe only the allele AP-3(1.0) in the Standard and Arrowhead inversions and the allele AP-3.98 in the Santa Cruz, Treeline, Cuernavaca and the Pikes Peak arrangements. The Chiricahua gene arrangement is polymorphic. (+info)A 189-bp repeat region within the human cytomegalovirus replication origin contains a sequence dispensable but irreplaceable with other sequences. (7/1042)
The human cytomegalovirus (HCMV) replication origin exhibits a strain-dependent difference in the number of copies of a 189-bp region: the AD169 and Towne strains contain one and three copies of the region, respectively. A nearly complete deletion of the 189-bp repeat region of the Towne strain does not eliminate the origin's ability to initiate DNA synthesis. Here we report that the replication ability of the HCMV replication origin in infected cells disappeared after replacements of an internal sequence (152 bp) of the 189-bp repeat region with lambda DNA of identical and different lengths as well as after introduction of multiple nucleotide substitutions within the 152-bp internal sequence of the 189-bp repeat. In contrast, a variation in the copy number of 189-bp region (either one or two copies) or an inversion of the 152-bp internal sequence of the 189-bp repeat maintained replication abilities similar to those of the wild-type origin of the Towne strain. These results indicate that the 189-bp repeat region within the HCMV replication origin is not just a dispensable spacer sequence but instead contains an irreplaceable sequence that may play a supporting role in HCMV DNA replication. (+info)Selective sweep at the Drosophila melanogaster Suppressor of Hairless locus and its association with the In(2L)t inversion polymorphism. (8/1042)
The hitchhiking model of population genetics predicts that an allele favored by Darwinian selection can replace haplotypes from the same locus previously established at a neutral mutation-drift equilibrium. This process, known as "selective sweep," was studied by comparing molecular variation between the polymorphic In(2L)t inversion and the standard chromosome. Sequence variation was recorded at the Suppressor of Hairless (Su[H]) gene in an African population of Drosophila melanogaster. We found 47 nucleotide polymorphisms among 20 sequences of 1.2 kb. Neutrality tests were nonsignificant at the nucleotide level. However, these sites were strongly associated, because 290 out of 741 observed pairwise combinations between them were in significant linkage disequilibrium. We found only seven haplotypes, two occurring in the 9 In(2L)t chromosomes, and five in the 11 standard chromosomes, with no shared haplotype. Two haplotypes, one in each chromosome arrangement, made up two-thirds of the sample. This low haplotype diversity departed from neutrality in a haplotype test. This pattern supports a selective sweep hypothesis for the Su(H) chromosome region. (+info)
Chromosome inversion - Simple English Wikipedia, the free encyclopedia
Periodic Reporting for period 1 - FITINV (Fitness consequences of chromosome inversion polymorphism in mimetic butterflies) |...
2017/18 ICD-10-CM Diagnosis Code Q95.1: Chromosome inversion in normal individual
Paracentric inversions | Article about paracentric inversions by The Free Dictionary
Evolutionary implications of inversions that have caused intra-strand parity in DNA | BMC Genomics | Full Text
Characterization of the human lineage-specific pericentric inversion that distinguishes human chromosome 1 from the homologous...
Project
Regulation of gene expression by site-specific inversion. - Semantic Scholar
Recombination and Gene Flux Caused by Gene Conversion and Crossing Over in Inversion Heterokaryotypes | Genetics
Mapping Regions Within Cosmopolitan Inversion In(3R)Payne Associated With Natural Variation in Body Size in Drosophila...
Yoga while on your period: Inversions are totally fine.
Dienekes Anthropology Blog: Age and origin of 17q21 inversion in humans
Dienekes Anthropology Blog: Age and origin of 17q21 inversion in humans
Chromosomal polymorphism in urban populations of Drosophila paulistorum
Fusion genes: what , why and how
Chromosome 9 Inversion or Duplication
Document
Inversion variants in the human genome: role in disease and genome architecture | Genome Medicine | Full Text
Nucleotide, cytogenetic and expression impact of the human chromosome 8p23.1 inversion polymorphism - Depósito Digital de...
Archived) SHSU NAMES PAYNE VICE PRESIDENT FOR ACADEMIC AFFAIRS
Pervis Payne: Death row inmate nearing execution granted bid for DNA testing in double murder - 95.1 WAPE
Rep Payne: Obama Makes War OK - Lets Try Democracy
Origin of the Australian-Antarctic Discordance from an ancient slab and mantle wedge - CaltechAUTHORS
Notes 4 | Matrix (Mathematics) | Determinant
Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex | Journal of Neuroscience
7 Benefits of Shoulderstand | Gaia
Five Popular and Magical Ways That Inversions Could Save Your Life - FeetUp® Yoga
Scene inversion slows the rejection of false positives through saccade exploration during search | www.icb.ucsb.edu
The Geological Society
OSA | Integral inversion to Fraunhofer diffraction for particle sizing
Payne County Youth Services Inc - (74074) - Stillwater, OK
Elliot Payne | Minneapolis College of Art and Design
Freda Payne - Payne And Pleasure - Vinyl LP - 1974 - US - Original | hhv.de
Craig Payne Discusses Trichomoniasis
Max Payne 2: The Fall of Max Payne • Eurogamer.net
Rita Ora: X Factor Concert with Liam Payne!: Photo 2806817 | Liam Payne, Rita Ora Pictures | Just Jared
Josh Payne - Barnet Football Club
HEALTH Compose Score for Max Payne 3 GamePhoto by...
Obsession Fitness | Exercise Equipment, Home Gyms - Paradigm 500 Inversion Table System | Back Therapy & Exercise Resistance -...
TurboFLASH FAIR Imaging with Optimized Inversion and Imaging Profiles<...
Leicester Research Archive: Genomic complexity of the Y-STR DYS19: inversions, deletions and founder lineages carrying...
Plus it
British Library EThOS: Studies in the Walden inversion : the relative configurations of laevorotatory-hydroxy compounds and...
scoreInvHap: Get inversion status in predefined regions version 1.0.0 from Bioconductor
Inversion Table Reviews - Find the Best Inversion Table - Inventive Step
About - Best Inversion Table Reviews
Inversion recovery legal definition of inversion recovery
Pericentric inversion | definition of pericentric inversion by Medical dictionary
Ecological and genetic relationships of the Forest-M form among chromosomal and molecular forms of the malaria vector Anopheles...
An attenuated strain of Bacillus anthracis (CDC 684) has a large chromosomal inversion and altered growth kinetics | BMC...
Footprints of Inversions at Present and Past Pseudoautosomal Boundaries in Human Sex Chromosomes : Genome Biology and Evolution...
Wellens syndrome | ECG Guru - Instructor Resources
Retrievals of aerosol single scattering albedo by multiwavelength lidar T measurements: Evaluations with NASA Langley HSRL-2...
Strong Stillness
Edges, Plateaus, and Yoga
Association of alleles of the malic dehydrogenase locus with a pericentric inversion in Drosophila robusta<...
hin - DNA-invertase hin - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - hin gene & protein
Bare Naked Words: ***Release Blitz Tour*** The Honor Series by Angel Payne
FMC Ft. Payne in Ft. Payne, AL - Dialysis Center Report - Services, Quality, Patient Survival, Reviews, Ratings, and More
Great British Bands / Jack Payne... | Jack Payne & His Orchestra | High Quality Music Downloads | 7digital United Kingdom
Louisa Mae Shelley b. 16 Jun 1866 Payne, Paulding County, Ohio, USA d. 10 Mar 1952 Payne, Paulding County, Ohio, USA: Tangled...
Dewpoint Temperature Inversions | Journal of Applied Meteorology and Climatology | American Meteorological Society
Gravity Training Boots Junior Comfort For Street Workout - Inversion Therapy - Back Pain Relief - Body Weight Abs Workout -...
NSCLC | ERIALCL.NET
Major Payne Movie Review & Film Summary (1995) | Roger Ebert
Suns lose sparkplug Cam Payne to injury in loss to Clippers
Association of Carotid Atherosclerosis With Electrocardiographic Myocardial Ischemia and Left Ventricular Hypertrophy |...
How to enable logging in websphere application server - Hosting Blog
Actomyosin contraction of the posterior hemisphere is required for inversion of the Volvox embryo | Development
Casco Bay protector, states first baykeeper, announces retirement - Portland Press Herald
Casebook Featured in NCSL Article on Child Welfare Information Systems
GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice | The EMBO Journal
Oceanic crust | Faculty of Engineering | Imperial College London
Why Should You Buy TAESOUW-Sports Beech Yoga Inversion Stool Handstand Artifact Inverted Aid Inversion Bench Chair Practice...
Plant of the Month | Theodore Payne Foundation
Dr. Jeremy Payne, MD - Phoenix, AZ - Vascular Neurology & Cerebrovascular Disorders | Healthgrades.com
Dr. William Payne V, MD - Warrenville, IL - Orthopedic Hand Surgery & Orthopedic Surgery | Healthgrades.com
K. Mark Payne - Find a Doctor | Charleston SC | MUSC Health
Howard Payne University occupational therapy
Howard Payne University dining hall menu
Whats New | Payne Pest Management
Howard Payne University nutrition program
Max Payne can be your life coach too
Dolley Payne Todd Madison | The White House
Howard Payne University CNA program
The Carter Payne Is The Newest Food Hall In Colorado
Australian Foreign Minister Marise Payne to visit India | India News | Zee News
You searched for chromosomal inversion - Biology Articles, Tutorials & Dictionary Online
Dper\GL17342 - GL17342 - Drosophila persimilis (Fruit fly) - Dper\GL17342 gene & protein
flipping inversion
Download Electron Gated Ion Channels With Amplification By Nh3 Inversion Resonance
Bac Trac Inversion Traction Device - Back in Action
Investigation of inversion domains in GaN by electric-force microscopy
Ancestral reconstruction
Watterson GA, Ewens WJ, Hall TE, Morgan A (1982). "The chromosome inversion problem". Journal of Theoretical Biology. 99 (1): 1 ... Sturtevant AH, Dobzhansky T (July 1936). "Inversions in the Third Chromosome of Wild Races of Drosophila Pseudoobscura, and ... Dobzhansky T, Sturtevant AH (January 1938). "Inversions in the Chromosomes of Drosophila Pseudoobscura". Genetics. 23 (1): 28- ... Various operations are allowed on these permutations, such as an inversion (a segment of the permutation is reversed in-place ...
Alfred Sturtevant
Chromosome Map. NCBI. April 11, 2007 gi?rid=gnd.chapter.272 Definition of Chromosome Inversion. April 11, 2007. http://www. ... Lattas, Chelsea K. Chromosome Inversions. Michigan State University. April 11, 2007 < http://www.msu.edu/~lattasch/inversion. ... This was the beginning of the chromosome theory; Roux viewed his findings as argument that chromosomes contain units of ... In 1913, he determined that genes were arranged on chromosomes in a linear fashion, like beads on a necklace. He also showed ...
Mark Kirkpatrick
Kirkpatrick, M.; Barton, N. H. (2006). "Chromosome inversions, local adaptation and speciation". Genetics. 173 (1): 419-434. ... His research touches on a wide variety of topics, including the evolution of sex chromosomes, sexual selection, and speciation ... He has also been actively involved in research on sex chromosome evolution and sex determination. Awards received include: ... Kirkpatrick has worked on questions in quantitative genetics, speciation, and chromosome evolution, focusing on the evolution ...
Oligoryzomys nigripes
de Almeida, Eunice Judith Cardoso; Yonenaga-Yassuda, Yatiyo (January 1991). "Pericentric inversions and sex chromosome ... There are 60 autosomal chromosomes and 2 sex chromosomes found in this species. Weksler et al., 2008 Musser, G.G.; Carleton, M. ... There are 31 pairs of chromosomes found in the Oligoryzomys nigripes species. The diploid formula for this species is 2n=62. ...
Drosophila pseudoobscura
Differs from CH only by an inversion on the third chromosome. "Drosophila pseudoobscura". Integrated Taxonomic Information ... In the D. pseudoobscura population, some males have a harmful chromosome called sex ratio (SR), where an inactive Y-chromosome ... Differs from AR only by a third chromsome inversion. Arrowhead or AR. ...
Acute myelomonocytic leukemia
AML with a translocation or inversion is seen in different chromosomes. Specifically, AML with inversion in chromosome 16 also ... a gene inactivation or activation has occurred due to chromosome translocations or inversion. AML-M4 with an inversion of ... chromosome 16 is caused by breakage and rearrangement within itself. Criteria for AMML is confirmed if the myeloblasts and ...
Structural variation in the human genome
These repeated sequences could cause deletions, duplications, inversions, and inverted duplication chromosomes. The products of ... The inversion breakpoint was found to be around a segmental duplication which is observed in many other inversion events. It is ... At this scale, the only observations made were differences in chromosome number and chromosome structure. These variants that ... An inversion is a section of DNA on a chromosome that is reversed in its orientation in comparison to the reference genome. ...
Koolen-De Vries syndrome
The orientation of low copy repeats flanking the deleted segment suggests the inversion in the parental chromosome influences ... "A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism". Nat Genet. 38 (9): 999-1001 ... A review of five patients found the parental chromosome from which the deletion originated carried a common 900kb inversion ... Rao PN, Li W, Vissers LE, Veltman JA, Ophoff RA (2010). "Recurrent inversion events at 17q21.31 microdeletion locus are linked ...
Chromosomal polymorphism
Possessing chromosomes of varying shapes is generally the result of a chromosomal translocation or chromosomal inversion. In a ... In some cases of differing counts, the difference in chromosome counts is the result of a single chromosome undergoing fission ... In an inversion, a segment of a chromosome is flipped end-for-end. All forms of chromosomal polymorphism can be viewed as a ... where it splits into two smaller chromosomes, or two undergoing fusion, where two chromosomes join to form one. This condition ...
Benign familial neonatal seizures
This occurs on chromosome 5 and the inversion is of the p15 through q11 area. Affected individuals, thus, have the karyotype 46 ... "Familial pericentric inversion of chromosome 5 in a family with benign neonatal convulsions". J Med Genet. 39 (3): 214-6. doi: ... The rarest cause of BFNE, occurring in only one known family, is a chromosomal inversion. ... and the third being a chromosomal inversion (BFNC3). There is no obvious correlation between most of the known mutations and ...
Fraser syndrome
An earlier born infant had Fraser syndrome and the same chromosome 9 inversion.[citation needed] Van Haelst et al. (2007) ... 2003) located the Fraser syndrome locus to chromosome 4q21. In 6 of 18 consanguineous families with Fraser syndrome, van Haelst ... Both the female fetus and the phenotypically normal father had a chromosome anomaly: inv(9)(p11q21). ...
Sabino horse
Brooks, S. A.; Lear, T. L.; Adelson, D. L.; Bailey, E. (2007). "A chromosome inversion near the KIT gene and the Tobiano ... The simple dominant allele responsible for the tobiano pattern (TO) is a large inversion approximately 100kb downstream of KIT ...
Drosophila
Herrera, P.; Taylor, M. L.; Skeats, A.; Price, T. A. R.; Wedell, N. (2014). "Can patterns of chromosome inversions in ... whereas humans have about 22,000 genes among their 23 chromosomes. Thus the density of genes per chromosome in Drosophila is ... There is a connection between the number of time females choose to mate and chromosomal variants of the third chromosome. It is ... His work on Drosophila earned him the 1933 Nobel Prize in Medicine for identifying chromosomes as the vector of inheritance for ...
Acute basophilic leukemia
Liu, P.P.; A. Hajara; C. Wijmengac; F.S. Collins (1995). "Molecular pathogenesis of chromosome 16 inversion in the M4E0 ... Cytogenetically heterogeneous but frequently associated with Philadelphia chromosome. There is no clinically distinguishing ...
CBFB
It is most commonly caused by an inversion of particular region of chromosome 16; however it can also be caused by ... In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N ... O'Reilly J, Chipper L, Springall F, Herrmann R (2000). "A unique structural abnormality of chromosome 16 resulting in a CBF ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 16, Oncogenes, All stub ...
Equine coat color genetics
Brooks; Lear; Adelson; Bailey (2007). "A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses". ... For the most part, chromosomes come in pairs, one chromosome from each parent. When both chromosomes have the same allele for a ... DNA is organized into storage structures called chromosomes. A chromosome is simply a very long piece of DNA, and a gene is a ... The Dun locus is TBX3 on equine chromosome 8. The molecular cause behind the dun coat colors is not entirely understood, but ...
Dominant white
Brooks; Lear; Adelson; Bailey (2007). "A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses". ... At the time there was no means of assigning W to a position on the chromosome, or to a gene. This family of white horses ... A locus is the physical location of a gene on a chromosome. For any particular gene, when an individual inherits two identical ... Tobiano is caused by an inversion starting about 100 kb downstream of KIT, and is also considered an allele of KIT. These ...
Alternative mating strategy
The variation in plumage colours are determined by an inversion mutation on chromosome 2. This is an example of alternative ...
Emerin
Approximately 20% of cases have X chromosomes with an inversion within the Xq28 region. Moreover, recent research have found ... Small K, Warren ST (Jan 1998). "Emerin deletions occurring on both Xq28 inversion backgrounds". Human Molecular Genetics. 7 (1 ... "Transcriptional organization of a 450-kb region of the human X chromosome in Xq28". Proc. Natl. Acad. Sci. U.S.A. 90 (23): ... Genes on human chromosome X, Molecular biology). ...
Glossary of genetics
paracentric inversion A chromosomal inversion in which the inverted segment does not include the chromosome's centromere. ... of a linear chromosome or chromosome fragment) Having no centromere. acrocentric (of a linear chromosome or chromosome fragment ... pericentric (of a gene or region of a chromosome) Positioned near to the centromere of the chromosome. pericentric inversion A ... In humans, the X chromosome and the Y chromosome are sex chromosomes. alpha helix (α-helix) A common structural motif in the ...
Glossary of genetics (M−Z)
paracentric inversion A chromosomal inversion in which the inverted segment does not include the chromosome's centromere. ... pericentric inversion A chromosomal inversion in which the inverted segment includes the chromosome's centromere. Contrast ... of a linear chromosome or chromosome fragment) Having a centromere positioned at the terminal end of the chromosome (near or ... of a linear chromosome or chromosome fragment) Having a centromere positioned in the middle of the chromosome, resulting in ...
Rabicano
brooks, SA; TL Lear; DL Adelson; E Bailey (2007). "A chromosome inversion near the KIT gene and the Tobiano spotting pattern in ...
Eukaryote hybrid genome
Hooper DM, Griffith SC, Price TD (March 2019). "Sex chromosome inversions enforce reproductive isolation across an avian hybrid ... mitonuclear loci residing on the Z chromosome in hybrid Italian sparrows is consistent with compatible sex chromosomes being ... A closely related observation is the large X effect stating that there is a disproportionate contribution of the X/Z-chromosome ... There are two main variants of hybrid species genomes: allopolyploid, which have one full chromosome set from each parent ...
Michelin tire baby syndrome
A child with multiple anomalies, smooth muscle hamartoma, and familial paracentric inversion of chromosome 7q". J Am Acad ...
AI-10-49
The pericentric chromosome inversion inv(16)(p13q22) creates the CBFB-MYH11 fusion gene, which encodes the CBFβ-SMMHC fusion ... "Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique ... including groups with the chromosome rearrangements inv(16)(p13q22) and t(8;21)(q22;q22). The chromosome translocation t(8;21)( ... The chromosome translocation t(12;21) (p13.1;q22) causes the fusion of the ETS variant 6 (ETV6) and RUNX1 genes results in ETV6 ...
Roan (horse)
Haase, B; Jude R; Brooks SA; Leeb T (June 2008). "An equine chromosome 3 inversion is associated with the tobiano spotting ... The region of the chromosome that harbors the roan gene is homologous to parts of chromosomes in other species that also ... While a chromosomal inversion of KIT causes tobiano white spotting, KIT also harbors one or more alleles responsible for sabino ... Paired chromosomes exchange parallel pieces of DNA, a process called chromosomal crossover, prior to being passed on to the ...
T-cell prolymphocytic leukemia
The most frequent chromosomal abnormality is the inversion of chromosome 14, specifically inv 14(q11;q32). This is found in 80 ... Brito-Babapulle V, Catovsky D (1991). "Inversions and tandem translocations involving chromosome 14q11 and 14q32 in T- ... Maljaei SH, Brito-Babapulle V, Hiorns LR, Catovsky D (1998). "Abnormalities of chromosomes 8, 11, 14, and X in T-prolymphocytic ... abnormalities of chromosome 8 are seen approximately 75% of patients, including idic (8p11), t(8;8)(p11-12;q12), and trisomy 8 ...
TMEM200A
"Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18". Psychiatric Genetics ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 6, Genes, Human proteins ... All stub articles, Human chromosome 6 gene stubs). ...
Biopsychiatry controversy
"Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18". Psychiatric Genetics ... "A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42". Molecular Psychiatry. 9 ...
Erythranthe
The perennials and annuals differ as groups from each other by an inversion sequence on chromosome 8. Evidence tentatively ...
Polymorphism (biology)
Chromosome Botany, p. 36. London: Allen & Unwin. *^ Darlington, C.D.; Mather, K. 1949. The Elements of Genetics, pp. 335-336. ... or if it is necessary for them to start on the same chromosome. Originally, it was held that chromosome rearrangement would ... However, many believe it more likely that the genes start on the same chromosome.[21] They argue that supergenes arose in situ ... This process might involve suppression of crossing-over, translocation of chromosome fragments and possibly occasional cistron ...
Biological basis of love
Evolutionary psychology has proposed several explanations for love. Monkey infants and children are for a very long time dependent on parental help. Love has therefore been seen as a mechanism to promote mutual parental support of children for an extended time period. Another is that sexually transmitted diseases may cause, among other effects, permanently reduced fertility, injury to the fetus, and increase risks during childbirth. This would favor exclusive long-term relationships reducing the risk of contracting an STD.[1] From the perspective of evolutionary psychology the experiences and behaviors associated with love can be investigated in terms of how they have been shaped by human evolution.[2] For example, it has been suggested that human language has been selected during evolution as a type of "mating signal" that allows potential mates to judge reproductive fitness.[3] Miller described evolutionary psychology as a starting place for further research: "Cognitive neuroscience could try ...
Syncope (medicine)
The lead genetic variant, residing at chromosome 2q31.1, is an intergenic variant approximately 250 kb downstream of the ... Signs of ARVD/C include T wave inversion and epsilon waves in lead V1 to V3.[32] ... "Genome-wide association study identifies locus at chromosome 2q32. 1 associated with syncope and collapse". Cardiovascular ... "Genome-wide association study identifies locus at chromosome 2q32. 1 associated with syncope and collapse". Cardiovascular ...
Polymorphism - Simple English Wikipedia, the free encyclopedia
Studies over many years have shown that natural populations of Drosophila are polymorphic for chromosome inversions.[27] The ... closely linked' means close on the same chromosome. *↑ Sheppard, Philip M. 1975. Natural selection and heredity. 4th ed, London ... When a part of a chromosome gets reversed end to end, so the genes run in the opposite direction to before. ... inversions are so common that they must be kept in the population by natural selection.[28][29] ...
Symbiogenesis
Consequently, the chromosomes of many eukaryotes contain genes that originated from the genomes of mitochondria and plastids.[ ... Some species including Pediculus humanus (lice) have multiple chromosomes in the mitochondrion. This and the phylogenetics of ... organelle genomes forge eukaryotic chromosomes". Nature Reviews Genetics. 5 (2): 123-135. doi:10.1038/nrg1271. PMID 14735123. ... organelle genomes forge eukaryotic chromosomes". Nature Reviews. Genetics. 5 (2): 123-35. doi:10.1038/nrg1271. PMID 14735123. ...
Mutation
Chromosomal translocations: interchange of genetic parts from nonhomologous chromosomes.. *Chromosomal inversions: reversing ... Changes in chromosome number may involve even larger mutations, where segments of the DNA within chromosomes break and then ... For example, in the Homininae, two chromosomes fused to produce human chromosome 2; this fusion did not occur in the lineage of ... of extra piece of a chromosome broken piece of a chromosome may become attached to a homologous or non-homologous chromosome so ...
Microhomology-mediated end joining
MMEJ is frequently associated with chromosome abnormalities such as deletions, translocations, inversions and other complex ...
Earliest known life forms
Earth remains the only place in the universe known to harbor life.[10][11] The origin of life on Earth was at least 3.77 billion years ago, possibly as early as 4.41 billion years ago.[2][4][5] The Earth's biosphere extends down to at least 19 km (12 mi) below the surface,[12][13][14][15] and up to at least 76 km (47 mi)[16] into the atmosphere,[17][18][19] and includes soil, hydrothermal vents, and rock.[20][21] Further, the biosphere has been found to extend at least 914.4 m (3,000 ft; 0.5682 mi) below the ice of Antarctica,[22][23][24] and includes the deepest parts of the ocean,[25][26][27] down to rocks kilometers below the sea floor.[26][28][29] In July 2020, marine biologists reported that aerobic microorganisms (mainly), in "quasi-suspended animation", were found in organically-poor sediments, up to 101.5 million years old, 76.2 m (250 ft) below the seafloor in the South Pacific Gyre (SPG) ("the deadest spot in the ocean"), and could be the longest-living life forms ever found.[30][31] ...
Deletion (genetics)
When a chromosome breaks, a part of it is deleted or lost, the missing piece of chromosome is referred to as deletion or a ... Chromosomal crossovers within a chromosomal inversion. *Unequal crossing over. *Breaking without rejoining ... Any number of nucleotides can be deleted, from a single base to an entire piece of chromosome.[1] Some chromosomes have fragile ... Abbreviations include a minus sign (-) for chromosome deletions, and del for deletions of parts of a chromosome.[7] ...
List of diseases (C)
... trisomy 8p Chromosome 8, trisomy 8q Chromosome 8, trisomy Chromosome 9 inversion or duplication Chromosome 9 Ring Chromosome 9 ... trisomy 3q Chromosome 3, trisomy 3q13 2 q25 Chromosome 3, Trisomy 3q2 Chromosome 4 - Chromosome 5 Chromosome 4 ring Chromosome ... Chromosome 7 Chromosome 6 ring Chromosome 6, deletion 6q13 q15 Chromosome 6, monosomy 6p23 Chromosome 6, monosomy 6q Chromosome ... trisomy 2q Chromosome 2, trisomy 2q37 Chromosome 20 - Chromosome 22 Chromosome 20 ring Chromosome 20, deletion 20p Chromosome ...
The Myth of the One Percent
This includes insertions and deletions as well as rearrangements and inversions of the genome. These genomic features help ... There are also differences in the genetic networks and chromosome structure that make it difficult to quantify the relative ...
Multiplex ligation-dependent probe amplification
For example, probes may be designed to target various regions of chromosome 21 of a human cell. The signal strengths of the ... Recent studies have shown that MLPA (as well as another variants such as iMLPA) is a robust technique for inversion ... "Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix ... "Computer-assisted prenatal aneuploidy screening for chromosome 13, 18, 21, X and Y based on multiplex ligation-dependent probe ...
Ciliate
The resulting macronuclear chromosomes often contain only a single gene. In Tetrahymena, the micronucleus has 10 chromosomes ( ... DNA inversion and translocation are required for "unscrambling". This process is guided by long RNAs derived from the parental ... The micronuclear chromosomes are fragmented into many smaller pieces and amplified to give many copies. ... Macronuclear division is accomplished by amitosis, and the segregation of the chromosomes occurs by a process whose mechanism ...
Fluorescence in situ hybridization
... have similar chromosomes but with increasing distance chromosomes tend to break and fuse and thus result in mosaic chromosomes ... such as translocations and inversions which are hallmark aberrations seen in many types of leukemia and lymphoma. Spectral ... FISH can be used to study the evolution of chromosomes. Species that are related have similar chromosomes. This homology can be ... Probes that hybridize along an entire chromosome are used to count the number of a certain chromosome, show translocations, or ...
Primary effusion lymphoma
... inversions, translocations), aneuploidy (i.e. increases or decreases in the number of chromosomes), and the abnormal expression ...
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing
Fortunately, the PAM NGG sequence occurs at 424,651 instances on both strands of the E. coli chromosome, so this method is not ... Subsequent applications built upon simple sequence corrections and successfully repaired a chromosomal inversion abnormality in ... Second, the wild-type gene is never removed from the chromosome. This means that PCR screening is able to more quickly identify ... Previous methods were successful in inserting 30bp into the chromosome while the SCAR-less method was able to insert a sequence ...
Genetics and the Origin of Species
Polyploid cells have a chromosome number that is more than twice the haploid number. The effects of polyploidy between two ... Chromosomal inversion, a reversal of a segment, is the basis for differentiation in Drosophila. He also points out that these ... While analyzing chromosome structure in wild populations of Drosophila pseudoobscura, Dobzhansky discovered a surprising amount ... He shows that chromosomal translocation, a rearrangement of parts in chromosomes, accounts for racial differences in Datura ...
Virtual karyotype
... chromosome 1) to smallest (chromosome 22), with the sex chromosomes (X and Y) shown last. Historically, karyotypes have been ... Therefore, virtual karyotypes cannot detect balanced translocations and inversions. They also can only detect genetic ... These include: A translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, occurs in about 20% of adult ... Gains on chromosomes 6 and 8 are often used to refine the predictive value of the Monosomy 3 screen, with gain of 6p indicating ...
Kinesin-like protein KIF11
The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle ... or inversion, of the spindle poles leaving centrally positioned centrosome pairs flanked by a radial array of microtubules with ... Genes on human chromosome 10, All articles with unsourced statements, Articles with unsourced statements from January 2020, ... its possible role in bipolar spindle assembly and chromosome alignment". Biochem J. 451 (2): 195-204. doi:10.1042/BJ20121447. ...
Drosophila subobscura
... genome has been used to track global climate change by measuring the magnitude and direction of shifts in chromosome inversion ... More than 65 inversions have been identified. D. subobscura is frequently used in evolutionary-biological studies. As D. ... Further data on inversion polymorphism in Greece-Evidence of microdifferentiation". Egypt. J. Genet. Cytol. 2 (12): 1-132. ... Polytene drawings and photomaps helped further the study of these inversions, allowing for the finding of more than 600 ...
Unicameral bone cyst
... deletion of some genetic material in a chromosome, or chromosomal inversion. These two fusion genes are described in FET gene ... Fusion genes are formed from two previously independent genes that become united due to a chromosome translocation, ...
Frosted myotis
It is a diploid species, with two copies each of 22 chromosomes, for a total of 44 chromosomes. It is found most often in ... Harada, M., & Uchida, T. A. (1982). Karyotype of a rare species, Myotis pruinosus, involving pericentric inversion and ...
Centromere
... such as Robertsonian translocation and paracentric inversion. Dicentric chromosomes can have a variety of fates, including ... Chromosome-breaking events can also generate acentric chromosomes or acentric fragments. A dicentric chromosome is an abnormal ... The monocentric chromosome is a chromosome that has only one centromere in a chromosome and forms a narrow constriction. ... but reside closer to the end of the chromosomes. An acentric chromosome is fragment of a chromosome that lacks a centromere. ...
Forward genetics
Afterward, chromosome walking and jumping techniques were used to identify the gene and sequence it. Forward genetics can work ... Ionizing radiation can be used to induce genome-wide mutations as well as chromosomal duplications, inversions, and ... Genetic-linkage studies were able to map the disease loci in cystic fibrosis to chromosome 7 by using protein markers. ... By the classical genetics approach, a researcher would then locate (map) the gene on its chromosome by crossbreeding with ...
LILRB3
v t e v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 19, Wikipedia ... Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor ...
H19 (gene)
... chromosomal inversion, chromosome deletions, single stranded breaks in DNA, double stranded breaks in DNA, the intercalation of ... On the human chromosome 11p15, the methylated paternal H19 allele replicates early in the S phase while the hypomethylated ... After 10 weeks gestation and in full term placentae, there is exclusive expression of H19 from the maternal chromosome. In the ... Genome instability can refer to the accumulation of extra copies of DNA/chromosomes, chromosomal translocations, ...
HOXC4
This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and ... "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute ... Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and ... Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E (1988). "At least three human homeoboxes on chromosome 12 belong ...
Not para-, not peri-, but centric inversion of chromosome 12. | Journal of Medical Genetics
... which also showed an abnormal chromosome 12. Fluorescence in situ hybridisation (FISH) analysis of the aberrant chromosome ... resulting in a pseudodicentric chromosome. Further FISH analyses using telomeric and subtelomeric probes showed that the other ... using a 12 specific centromeric probe showed a break in the alphoid repeats followed by an inversion within the short arm, ...
Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans |...
dGH chromosome paints uniformly label a single sister chromatid of a chromosome. Panel B: An inversion (double signal switch; ... dGH chromosome paints uniformly label a single sister chromatid of a chromosome. Panel B: An inversion (double signal switch; ... chromosomes, as well as exchanges that occur among the uniquely painted chromosomes, whereas for inversions, the correction to ... Chromosome Translocations, Inversions and Telomere Length for Retrospective Biodosimetry on Exposed U.S. Atomic Veterans Miles ...
Chromosome inversion; Inversion, Chromosome
Inversion, Chromosome. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms ... Chromosome inversion (Inversion, Chromosome). An aberration in which a chromosomal segment is deleted and reinserted in the ... Ranked list of diseases related to "chromosome inversion"Drugs, active principles and "chromosome inversion"Medicinal plants ... so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome. ...
Chromosome 9 inversion - Rare Medical News
pericentric inversion. .[2] Chromosome 9 inversion is one of the most common structural balanced chromosomal variants, with an ... Humans have 23 pairs of chromosomes, which means that each human cell contains 46 chromosomes. Each chromosome has a p and q ... paracentric inversion. . If one break occurs in the short arm and the other in the long arm of the chromosome, then this is ... An inversion occurs when there are two breaks in one chromosome. The segment between the breakpoints flips around and reinserts ...
Familial pericentric and paracentric inversions of chromosome 1. | Profiles RNS
Koolen-de Vries syndrome: MedlinePlus Genetics
An inversion involves two breaks in a chromosome; the resulting piece of DNA is reversed and reinserted into the chromosome. ... A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism. Nat Genet. 2006 Sep;38(9):999 ... So while the inversion is very common, only an extremely small percentage of parents with the inversion have a child affected ... Chromatin is the complex of DNA and protein that packages DNA into chromosomes. The protein produced from the KANSL1 gene is ...
Search
Comparative Cytogenetics of the Black Ghost Knifefish (Gymnotiformes: Apteronotidae): Evidence of Chromosomal Fusion and...
The diploid chromosome number was 2n = 24 for A. albifrons, but with difference in the karyotype structure and fundamental ... Evidence of Chromosomal Fusion and Pericentric Inversions in Karyotypes of Two Apteronotus Species Zebrafish. 2017 Oct;14(5): ... However, there are more C-banded chromosomes in A. caudimaculosus than A. albifrons. The sites of 18S DNA as revealed by ... In A. caudimaculosus, the diploid chromosome number was 2n = 26, which was classified as 22 metacentric (m), 2 submetacentric ( ...
Chromosome inversions, adaptive cassettes and the evolution of species' ranges. | Mol Ecol;24(9): 2046-55, 2015 May. |...
Chromosome inversions, adaptive cassettes and the evolution of species ranges.. Kirkpatrick, Mark; Barrett, Brian. Mol Ecol ; ... A chromosome inversion can spread when it captures locally adapted alleles or when it is introduced into a species by ... Introgression of an inversion that carries novel, locally adapted alleles is a particularly powerful mechanism for range ... These results suggest a role for inversions as cassettes of genes that can accelerate adaptation by crossing species boundaries ...
A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success :: MPG.PuRe
A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success ... A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success Knief, U., Forstmeier, W., ... 2017). A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success. Nature Ecology & ...
Genetics Basics | CDC
We explain the different number of chromosomes and changes in chromosomes. We also talk about complex conditions. ... A translocation is when part of one chromosome has moved to another chromosome. An inversion is when part of a chromosome has ... Chromosomes come in pairs and humans have 46 chromosomes, in 23 pairs. Children randomly get one of each pair of chromosomes ... The chromosomes that form the 23rd pair are called the sex chromosomes. They decide if a person is born a male or female. A ...
Acute Myeloid Leukemia (AML) Subtypes and Prognostic Factors
Translocation or inversion of chromosome 16. *Translocation between chromosomes 15 and 17 (seen most often in patients with M3) ... Abnormalities of chromosome 11 (at the spot q23). *Loss of a chromosome, so the cell has only 1 copy instead of the normal 2 ( ... Chromosome (cytogenetic) abnormalities AML cells can have many kinds of chromosome changes, some of which can affect a persons ... AML with certain genetic abnormalities (gene or chromosome changes). *AML with a translocation between chromosomes 8 and 21 [t( ...
Sturge-Weber Syndrome: Practice Essentials, Background, Pathophysiology
Inversion of chromosome arm 4q and trisomy 10 were seen in one patient each. Shirley et al identified a somatic activating c. ... 28] on chromosome 9 (at 9q21.2), appears to cause alterations in regulation of the structure and function of blood vessels, ... 548G-,A mutation in GNAQ (on chromosome 9q21) in samples of affected tissues, in 23 out of 26 study participants with SWS. [28 ...
Search
CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate: Cell
Fetal anomalies associated with an inversion duplication 13 chromosome.. Obstet. Gynecol. 1988; 71: 991-994. *PubMed ... Chemical subdomains within the kinetochore of isolated CHO mitotic chromosomes.. J. Cell Biol. 1991; 114: 285-294. *Scopus (78) ... Chromosomes move polewardin anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. ... Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and ...
Malaria: a genetic marker helps identify super-spreading mosquitoes - press release Institut Pasteur
The 2La genetic marker is a chromosome inversion. In Anopheles mosquitoes, this genetic variation is present in two forms: the ... The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa, eLife, ... Called the 2La inversion, this marker is a frequent and geographically widespread genetic difference found in Anopheles gambiae ... The study found that mosquitoes carrying the 2L+a genetic marker inversion (aka the susceptible marker) are twice as likely to ...
Genomic architecture of adaptive radiation and hybridization in Alpine whitefish | Nature Communications
Kirkpatrick, M. & Barton, N. Chromosome inversions, local adaptation and speciation. Genetics 173, 419-434 (2006). ... De‐Kayne, R., Zoller, S. & Feulner, P. G. D. A de novo chromosome‐level genome assembly of Coregonus sp. Balchen: one ... De-Kayne, R., Zoller, S. & Feulner, P. G. D. Data from: a de novo chromosome-level genome assembly of Coregonus sp. "Balchen": ... We also identified genes that were annotated on chromosome-scale scaffolds in the whitefish reference genome47 which overlapped ...
WHO EMRO | Chromosomal aberrations in children with suspected genetic disorders | Volume 3, issue 1 | EMHJ volume 3, 1997
... inversion péricentrique du chromosome 9 (2; 1,5%), marqueur chromosomique (2; 1,5%) et aberrations des chromosomes sexuels (4 ... marker chromosome (2; 1.5%) and sex chromosome aberrations (4; 2.9%). All of them showed phenotypic-cytogenetic heterogeneity. ... pericentric inversion of chromosome 9 (2; 1.5%), marker chromosome (2; 1.5%) and sex chromosome aberrations (4; 2.9%). All of ... inversion péricentrique du chromosome 9 (2; 1,5%), marqueur chromosomique (2; 1,5%) et aberrations des chromosomes sexuels (4; ...
Cell Journal
Pericentric inversion of chromosome 9 was seen in 5% of patients. This inversion was prevalent in patients with recurrent ... Chromosome Abnormalities and Viability of Vitrified Eight-Cell Mouse Embryos at Presence of Two Different Cryoprotectants at ... Experiments were conducted to find the differences between post-thaw viability and chromosome aberrations in eight-cell mouse ... Embryo survival was assessed by in vitro development, and chromosome abnormalities were analyzed by Giemsa staining. The ...
Exon skipping in the KIT gene causes a Sabino spotting pattern in horses | Semantic Scholar
Chromosome Fragility
Summary Report | CureHunter
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other ... Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other ... affecting all chromosomes. ". 11/01/2015 - "This chromosome fragility involves the generation of chromosome/chromatid gaps or ... Chromosome Fragility. Subscribe to New Research on Chromosome Fragility ...
Volume 39 Issue 4 | Journal of Medical Entomology
KEYWORDS: Anopheles gambiae, chromosome inversions, heterosis, insecticide resistance, Mali, Cote dIvoire. Read Abstract + ... Inversion 2La has previously been associated with dieldrin resistance and inversion 2Rb shows an association with DDT ... Two paracentric inversions namely 2La and 2Rb are highly ubiquitous in the wild and laboratory populations sampled. Both ... Stable Chromosomal Inversion Polymorphisms and Insecticide Resistance in the Malaria Vector Mosquito Anopheles gambiae (Diptera ...
Publication Year: 2008 / Subject term: plant morphology - PubAg Search Results
Differences in sex chromosomes, fixed inversions, and the kind and frequency of floating inversions revealed five cytoforms (A ... chromosome inversions; sex linkage; males; phylogeny; molecular systematics; sex chromosomes; larvae; insect ecology; plant ... Zea mays; plant development; plant architecture; chromosomes; corn; chromosome translocation. DOI:. 10.1534/genetics.108.091843 ... chromosome pairing; Helianthus argophyllus; chromosome mapping; inbred lines; interspecific hybridization; wild relatives; ...
Microhomology-mediated end joining - Wikipedia
Biblio | UW Biology
Biologia i Ecologia Bentòniques - Genètica: Francesc Mestres
MESTRES, F., BALANYA, J., SEGARRA, C., PREVOSTI, A. and SERRA, L. (1994). "O chromosome inversion polymorphism in Northern and ... "Inversions and adaptation to the plant toxin ouabain shape DNA sequence variation within and between chromosomal inversions of ... MESTRES, F. and SERRA, L. (1999). "Distribution of lethal genes and their allelism in the O chromosome of D. subobscura". J. ... ZIVANOVIC, G. and MESTRES, F. (2000). "Lethal genes in O5 chromosomes of D. subobscura from Europe and America". J. Zool. Syst ...
Gene regulatory effects of a large chromosomal inversion in highland maize<...
Chromosome Inversion Medicine & Life Sciences 100% * Zea mays Medicine & Life Sciences 77% ... Chromosomal inversions play an important role in local adaptation. Inversions can capture multiple locally adaptive functional ... N2 - Chromosomal inversions play an important role in local adaptation. Inversions can capture multiple locally adaptive ... AB - Chromosomal inversions play an important role in local adaptation. Inversions can capture multiple locally adaptive ...
TranslocationDeletionsDeletionAberrationsPericentric InversionsAbnormalitiesDuplicationsKaryotypeAberrationMutationGenomeHumansParacentric inversionGene on the X chromosomePairsLarge chromosomalAbnormal chromosomeAbnormalityGeneticsGenesExtra chromosomePolymorphismPopulationsAneuploidyGenomicDisordersCentromeresCytogeneticSegmentMonosomyAutosomalAdaptiveDominantDrosophilaMaizeMetacentricChromatinFrequentOnsetPolymorphismsInfertilityRepeatsFrequenciesAdaptationVariantsVariationHumanSyndromeOccursFamilialLocallyMalesDisorderSusceptibleRepetitivePair
Translocation3
- A translocation is when part of one chromosome has moved to another chromosome. (cdc.gov)
- In some individuals, 2q37 microdeletion syndrome results from chromosome rearrangements involving 2q37 (e.g., chromosome 2 inversion, ring chromosome 2, or translocation between chromosome 2 and another chromosome). (erasingdavid.com)
- We actually can cure AIDS and cancer with RA SHIELD, since these two diseases are caused by the failure in crystallization of Chromosomes due to failure of Wave Optics during cell division (so-called translocation, transposition, deletions, and other structural defects of chromosomes). (wordpress.com)
Deletions4
- MMEJ is frequently associated with chromosome abnormalities such as deletions, translocations, inversions and other complex rearrangements. (wikipedia.org)
- Previously interstitial deletions of chromosome 4p have only been rarely described. (lww.com)
- Y chromosome infertility is caused by deletions of genes in the AZF regions. (erasingdavid.com)
- Therefore, despite the great success in developing human genome maps of deletions and duplications, the mapping of inversions has lagged behind. (biomedcentral.com)
Deletion8
- Most people with Koolen-de Vries syndrome caused by a deletion have had at least one parent with a common variant of the 17q21.31 region of chromosome 17 called the H2 lineage. (medlineplus.gov)
- Missing a small part of a chromosome is called a deletion. (cdc.gov)
- A boy with 13.34-Mb interstitial deletion of chromosome 4p15. (lww.com)
- We report on a 12-year-old female with both a partial duplication and deletion involving chromosome 6. (hindawi.com)
- Although a majority of chromosomal duplication-deletion cases have resulted from a parental pericentric inversion, the parents of our case have normal chromosomes. (hindawi.com)
- What causes Y chromosome deletion? (erasingdavid.com)
- Three regions of the Y chromosome appear particularly susceptible to deletion and are termed AZFa, AZFb, and AZFc. (erasingdavid.com)
- AA/C1, AA/C1/SB, and AA/C1/SB10 cell lines have common chromosomal abnormalities including a pericentric inversion of chromosome 1 with deletion of part of the short arm and monosomy for chromosome 18. (aacrjournals.org)
Aberrations7
- or other CHROMOSOME BREAKAGE related aberrations. (curehunter.com)
- 0.001) of chromosome fragility, as well as other numerical and structural aberrations in breast cancer patients when compared to the control group. (curehunter.com)
- Chromosome aberrations as a biological dose-response indicator of radiation exposure in uranium miners. (cdc.gov)
- The relationship between radiation exposure and chromosome aberrations was studied in uranium miners (SIC-1094). (cdc.gov)
- All aberrations except inversions plus translocations were less prevalent in workers exposed for more than 3000WLM than in workers exposed 700 to 2890WLM. (cdc.gov)
- The authors conclude that except for dicentrics plus rings the prevalence of chromosome aberrations is a sensitive biological indicator of low level irradiation among uranium miners. (cdc.gov)
- is determined in men when reduced testosterone production is suspected, e.g. in hypogonadism, estrogen therapy, chromosome aberrations (as in the Klinefelter's syndrome) and liver cirrhosis. (cdc.gov)
Pericentric Inversions1
- The most persistent pattern of aberration increases with increasing dose occurred in the pericentric inversions plus translocations grouping. (cdc.gov)
Abnormalities3
- Chromosome Abnormalities. (raremedicalnews.com)
- Alternate explanations for the origin of the patient's chromosome abnormalities include parental gonadal mosaicism, nonallelic homologous recombination, or potentially intrachromosomal transposition of the telomeres of chromosome 6. (hindawi.com)
- When distal trisomy 6p and distal monosomy 6q do occur together, the abnormalities normally are the result of a parental pericentric inversion. (hindawi.com)
Duplications1
- The great majority of sporadic and familial cases show no cytogenetic abnormality, but approximately 2% carry duplications, inversions, or translocations affecting distal 11p. (jci.org)
Karyotype6
- The diploid chromosome number was 2n = 24 for A. albifrons, but with difference in the karyotype structure and fundamental number values between two populations under study. (nih.gov)
- The karyotypes of A. albifrons and A. caudimaculosus indicated a reduction of 2n resulting from chromosomal fusion, as could be hypothesized from the presence of an interstitial telomere sequence in two chromosome pairs in karyotype of A. caudimaculosus. (nih.gov)
- This collage of photomicrographs depicts the karyotype that would represent the chromosomal configuration seen in a human being with what is known as a chromosome 17 inversion. (cdc.gov)
- A karyotype represents a complete set of chromosomes in each and every eukaryote cell of an individual organism. (cdc.gov)
- Males with normal karyotype, for example, should not be heterozygous for polymorphisms exclusive to the X chromosome, and normal females should show no signals for polymorphisms exclusive to the Y chromosome. (biomedcentral.com)
- complex described above, karyotype analysis of the female ovarian chromosomes has revealed further subdivision into chromosomal forms called Forrest, Mopti (M) and Savanna (S) [ 7 ]. (cdc.gov)
Aberration3
- Various confounding factors were also evaluated for potential effects on chromosome aberration frequencies. (allenpress.com)
- Taken together, we find that our approach of combined chromosome aberration-based retrospective biodosimetry provided reliable dose estimation capability, particularly on a group average basis, for exposures above statistical detection limits. (allenpress.com)
- An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation , so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome. (lookfordiagnosis.com)
Mutation6
- A small number of individuals with Koolen-de Vries syndrome do not have a chromosome 17 microdeletion but instead have a mutation within the KANSL1 gene that causes one copy of the gene to be nonfunctional. (medlineplus.gov)
- It is caused by a mutation in a gene found on chromosome 11. (cdc.gov)
- A mutation in which a section of chromosome is reversed 180 degrees. (berkeley.edu)
- Is the mechanism of mutation different for Y-chromosome microdeletion? (erasingdavid.com)
- PGT-M involves a close examination of the mutation carried by an individual and the area of the chromosome surrounding it. (thebridgeclinic.com)
- The Brugada disease, the last clinico-cardiologic entity described in the 20th century, initially called right bundle branch block syndrome with ST segment elevation from V1 to V2 or V3 and sudden cardiac death, is genetically determined in a dominant autosomal mode, and it affects the alpha subunit of the Na+ channel by alteration of chromosome 3 and mutation in the SCN5A gene. (southampton.ac.uk)
Genome10
- Linkage studies are either performed as full genome screens with a dense set of genetic markers covering all chromosomes, or locally (fine-mapping) at a certain chromosomal area of interest. (springer.com)
- With the advent of paired-end sequencing approaches, it is now possible to map inversions across the human genome. (biomedcentral.com)
- Based on the paired-end sequencing studies published to date, it is now feasible to make a first map of inversions across the human genome and to use this map to explore the characteristics and distribution of this form of variation. (biomedcentral.com)
- Further characterization of inversions should be considered as an important step towards a deeper understanding of human variation and genome dynamics. (biomedcentral.com)
- It is still not clear how many common inversions exist in the human genome, what the size distribution of inversions variants is, and to what extent inversions are associated with human disorders. (biomedcentral.com)
- As a consequence, our understanding of the extent of inversion variants in the human genome has increased dramatically in the past few years. (biomedcentral.com)
- This review will give an overview of the current knowledge of inversions in the human genome, the methods used to discover and type inversions, and their role in human disease and human genome architecture. (biomedcentral.com)
- Genome Polymorphism Scans (hereafter Scans) are defined as the typing of a set of DNA polymorphisms spanning the length of each chromosome within a genome. (biomedcentral.com)
- The outbreak strain genome comprises 3 chromosomes and a plasmid, sharing an average nucleotide identity of 98.4% with B. stabilis ATCC27515 BAA-67, but with 13% novel coding sequences. (cdc.gov)
- The RA SHIELD was released by Wave Genome LLC to help its clients restore the Wave Optics of chromosomes under the condition of the SARS-CoV-19 pandemic. (wordpress.com)
Humans5
- Humans have 23 pairs of chromosomes, which means that each human cell contains 46 chromosomes. (raremedicalnews.com)
- Chromosomes come in pairs and humans have 46 chromosomes, in 23 pairs. (cdc.gov)
- Because the regulation of imprinted genes in the homologous region in the mouse (distal region of chromosome 7) is broadly conserved between mice and humans, experiments in mice have complemented molecular analyses of BWS pathology and have contributed greatly to our current knowledge of mammalian genomic imprinting mechanisms. (jci.org)
- In humans, aneuploidy would be any number of chromosomes other than the usual 46. (genome.gov)
- Humans have 22 pairs of autosomes and one pair of sex chromosomes (XX or XY). (genome.gov)
Paracentric inversion2
- If both breaks occur in the same arm of the chromosome, this is called a paracentric inversion . (raremedicalnews.com)
- [ 3 ] The term Ambras syndrome was coined, and subsequent genetic analyses in 2 patients have revealed an association with a paracentric inversion of band 8q22. (medscape.com)
Gene on the X chromosome2
- X-linked recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder. (raremedicalnews.com)
- It is caused by a change in a gene on the X chromosome. (cdc.gov)
Pairs4
- If the gene is on one of the first 22 pairs of chromosomes, called the autosomes, the genetic disorder is called an autosomal condition. (cdc.gov)
- People usually have 23 pairs of chromosomes. (cdc.gov)
- The chromosomes are arranged in pairs, and aligned using the position of each chromosome's centromere. (cdc.gov)
- Preimplantation Genetic Testing for Aneuploidy (PGT-A) formerly known as Preimplantation Genetic Screening (PGS) is a procedure that allows the identification and transfer of euploid (chromosomally normal) embryos by screening all 23 pairs of the human chromosome for aneuploidy. (thebridgeclinic.com)
Large chromosomal1
- It has long been possible to detect inversions of large chromosomal regions in G-banded karyotypes. (biomedcentral.com)
Abnormal chromosome2
- A 39 year old male with primary infertility was diagnosed as having Klinefelter syndrome by conventional cytogenetic analysis, which also showed an abnormal chromosome 12. (bmj.com)
- Rhoades MM , Dempsey E. The Effect of Abnormal Chromosome 10 on Preferential Segregation and Crossing over in Maize. (academictree.org)
Abnormality1
- Aneuploidy is an abnormality in the number of chromosomes in a cell due to loss or duplication. (genome.gov)
Genetics1
- The genetics of BWS are complex, but evidence for genomic imprinting effects is present for each of the 3 major subgroups of patients (familial, sporadic, and those with chromosome anomalies) (see ref. 3 and references cited therein). (jci.org)
Genes4
- These results suggest a role for inversions as cassettes of genes that can accelerate adaptation by crossing species boundaries, rather than protecting genomes from introgression. (bvsalud.org)
- People get (inherit) their chromosomes , which contain their genes , from their parents. (cdc.gov)
- Parental allele-specific alterations in the chromosome environment of imprinted genes are revealed by the presence of asynchronous DNA replication and differences in chromatin structure and modification (e.g., histone acetylation). (jci.org)
- Procesos que se dan en distintos organismos, por el que surgen nuevos genes. (bvsalud.org)
Extra chromosome2
- Having an extra chromosome is called trisomy. (cdc.gov)
- Down syndrome (DS) is the most common genetic disorder, resulting from an extra chromosome in pair 21. (bvsalud.org)
Polymorphism1
- Medium-term changes in Drosophila subobscura chromosomal inversion polymorphism: a possible relation with global warming? (ub.edu)
Populations3
- A number of paracentric chromosomal inversions have been observed as polymorphisms in wild and laboratory populations of this species. (bioone.org)
- Two paracentric inversions namely 2La and 2Rb are highly ubiquitous in the wild and laboratory populations sampled. (bioone.org)
- In this study, we used large-scale transcriptomic data to dissect the functional importance of a 13 Mb inversion locus (Inv4m) found almost exclusively in highland populations of maize (Zea mays ssp. (elsevier.com)
Aneuploidy1
- The goal of PGT-A is to identify embryos (presumed to be chromosomally normal) with aneuploidy, which will detect chromosomal status including missing or additional chromosome(s) such as Down syndrome, Turner's syndrome, Patau's syndrome, Edward's syndrome, abnormal sperm parameters etc. (thebridgeclinic.com)
Genomic2
- 80 years) veteran controls were collected and evaluated for radiation-induced chromosome damage utilizing directional genomic hybridization (dGH), a cytogenomics-based methodology that facilitates simultaneous detection of translocations and inversions. (allenpress.com)
- Although we could not confidently identify the causal alleles within Inv4m, this research accelerates progress towards understanding this inversion and will guide future research on these important genomic features. (elsevier.com)
Disorders3
- Genetic disorders often are described in terms of the chromosome that contains the gene that is changed in people who have the disorder. (cdc.gov)
- Some disorders are caused by having a different number of sex chromosomes. (cdc.gov)
- What disorders are carried on the Y chromosome? (erasingdavid.com)
Centromeres1
- In addition, we used indirect immunofluorescence to demonstrate that these antibodies recognize centromeres of HeLa chromosomes in the expected pattern for CENP-C. Localization of CENP-C by immunoelectron microscopy reveals that this protein is a component of the inner kinetochore plate. (cell.com)
Cytogenetic4
- Rhoades MM , Dempsey E. Cytogenetic Studies on a Transmissible Deficiency in Chromosome 3 of Maize Journal of Heredity . (academictree.org)
- Rhoades MM , Dempsey E. Cytogenetic Studies Of Deficient‐Duplicate Chromosomes Derived From Inversion Heterozygotes In Maize American Journal of Botany . (academictree.org)
- Rhoades MM . A Cytogenetic Study of a Chromosome Fragment in Maize. (academictree.org)
- Traditional cytogenetic approaches have long been able to identify microscopic inversion events, but discovery of submicroscopic events has remained elusive and largely ignored. (biomedcentral.com)
Segment5
- The segment between the breakpoints flips around and reinserts back into the chromosome. (raremedicalnews.com)
- In the H2 lineage, a 900 kb segment of DNA, which includes the region deleted in most cases of Koolen-de Vries syndrome, has undergone an inversion . (medlineplus.gov)
- We mapped the causative variant to a 37 kb segment on bovine chromosome 3. (plos.org)
- However, this strategy is limited to identification of variants that are several megabases in size, and even significantly larger inversions may escape detection if the inverted segment leads to little difference in the banding pattern. (biomedcentral.com)
- 2. Calo AA, The triad secondary R wave, RS-T segment elevation and T waves inversion in rigth precordial leads: a normal electrocardiographic variant. (southampton.ac.uk)
Monosomy1
- Missing a chromosome is called monosomy. (cdc.gov)
Autosomal2
- Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype. (raremedicalnews.com)
- Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
Adaptive3
- Chromosome inversions, adaptive cassettes and the evolution of species' ranges. (bvsalud.org)
- Inversions can capture multiple locally adaptive functional variants in a linked block by repressing recombination. (elsevier.com)
- The observed frequencies of the inversions that define these types are correlated with different ecological zones suggesting that they may have an adaptive character. (cdc.gov)
Dominant2
- X-linked dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome. (raremedicalnews.com)
- Like X-linked dominant diseases, Y chromosome-linked diseases are also extremely rare. (erasingdavid.com)
Drosophila2
Maize5
- Rhoades MM , Dempsey E, Ghidoni A. Chromosome elimination in maize induced by supernumerary B chromosomes. (academictree.org)
- Rhoades MM , Dempsey E. Induction of chromosome doubling at meiosis by the elongate gene in maize. (academictree.org)
- Rhoades MM . Chromosomes, Mutations, and Cytoplasm in Maize. (academictree.org)
- Rhoades MM . Studies of a Telocentric Chromosome in Maize with Reference to the Stability of Its Centromere. (academictree.org)
- Genetic Studies with Factors in the Tenth Chromosome in Maize. (academictree.org)
Metacentric1
- In A. caudimaculosus, the diploid chromosome number was 2n = 26, which was classified as 22 metacentric (m), 2 submetacentric (sm), and 2 acrocentric (a) chromosomes. (nih.gov)
Chromatin2
- Chromatin is the complex of DNA and protein that packages DNA into chromosomes. (medlineplus.gov)
- Rhoades MM , Dempsey E. Chromatin Elimination Induced by the B Chromosome of MaizeI. (academictree.org)
Frequent1
- Called the 2La inversion, this marker is a frequent and geographically widespread genetic difference found in Anopheles gambiae mosquitoes, the major African malaria vector. (pasteur.fr)
Onset1
- A 47-kd human nuclear protein recognized by antikinetochore autoimmunesera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation. (cell.com)
Polymorphisms1
- This is achieved through the typing of polymorphisms on the sex chromosomes. (biomedcentral.com)
Infertility2
- Muthuvel A, Ravindran M, Chander A, Subbian C. Pericentric inversion of chromosome 9 causing infertility and subsequent successful in vitro fertilization. (raremedicalnews.com)
- Y chromosome microdeletions (YCMDs) are the second most common genetic cause of male infertility. (erasingdavid.com)
Repeats1
- Fluorescence in situ hybridisation (FISH) analysis of the aberrant chromosome using a 12 specific centromeric probe showed a break in the alphoid repeats followed by an inversion within the short arm, resulting in a pseudodicentric chromosome. (bmj.com)
Frequencies1
- Perhaps not surprisingly, smoking and age-associated increases in background frequencies of inversions were observed. (allenpress.com)
Adaptation1
- Chromosomal inversions play an important role in local adaptation. (elsevier.com)
Variants4
- Chromosome 9 inversion is one of the most common structural balanced chromosomal variants, with an estimated incidence of about 3.5 percent. (raremedicalnews.com)
- Despite this progress, our understanding of inversion variants is still very restricted. (biomedcentral.com)
- While unbalanced variants such as copy number variations can be mapped using array-based approaches, strategies for characterization of inversion variants have been limited and underdeveloped. (biomedcentral.com)
- The long history of chromosomal studies in cytogenetics has led to the identification of several inversion variants, or heteromorphisms, that exist in the population but that have no clinical significance [ 15 ]. (biomedcentral.com)
Variation1
- In Anopheles mosquitoes, this genetic variation is present in two forms: the 2La genetic sequence and the 2L+ a genetic inversion. (pasteur.fr)
Human3
- Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (nih.gov)
- Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (nih.gov)
- This review provides an overview of the current knowledge about human inversions and their contribution to human phenotypes. (biomedcentral.com)
Syndrome6
- The microdeletion that causes Koolen-de Vries syndrome occurs on the long (q) arm of chromosome 17 at a location designated q21.31. (medlineplus.gov)
- So while the inversion is very common, only an extremely small percentage of parents with the inversion have a child affected by Koolen-de Vries syndrome. (medlineplus.gov)
- For example, people with Down syndrome have an extra copy of chromosome 21. (cdc.gov)
- For example, people with Turner syndrome usually have only one sex chromosome, an X. Women with Turner syndrome can have problems with growth and heart defects. (cdc.gov)
- For example, people with Williams syndrome are missing a small part of chromosome 7. (cdc.gov)
- A case of Weill-Marchesani syndrome with inversion of chromosome 15. (elsevier.com)
Occurs3
- An inversion occurs when there are two breaks in one chromosome. (raremedicalnews.com)
- If one break occurs in the short arm and the other in the long arm of the chromosome, then this is called a pericentric inversion . (raremedicalnews.com)
- A chromosomal inversion occurs when a chromosome breaks in two places, and the piece of genetic material broken away is flipped around and reinserted into the same chromosome. (cdc.gov)
Familial1
- Familial pericentric and paracentric inversions of chromosome 1. (uchicago.edu)
Locally2
- A chromosome inversion can spread when it captures locally adapted alleles or when it is introduced into a species by hybridization with adapted alleles that were previously absent. (bvsalud.org)
- Introgression of an inversion that carries novel, locally adapted alleles is a particularly powerful mechanism for range expansion. (bvsalud.org)
Males1
- Because only males have a Y chromosome and they always receive their Y chromosome from their father, Y-linked single-gene diseases are always passed on from affected fathers to their sons. (erasingdavid.com)
Disorder1
- If the gene is on the X chromosome, the disorder is called X-linked. (cdc.gov)
Susceptible1
- The study found that mosquitoes carrying the 2L+ a genetic marker inversion (aka the susceptible marker) are twice as likely to be infected with malaria than mosquitoes carrying the other form (i.e. 2La). (pasteur.fr)
Repetitive1
- Meiotic recombination errors in highly repetitive sequences in the Y chromosome result in microdeletions. (erasingdavid.com)