Regions along polytene chromosomes that are uncondensed and active in DNA REPLICATION or RNA transcription (GENETIC TRANSCRIPTION).
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
The portion of chromosome material that remains condensed and is transcriptionally inactive during INTERPHASE.
Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.
A family of POU domain factors that bind the octamer motif ATTTGCAT in enhancer and PROMOTER REGIONS to regulate GENE EXPRESSION.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
Apparatus and instruments that generate and operate with ELECTRICITY, and their electrical components.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Substances and products derived from NICOTIANA TABACUM.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Items used to aid in ending a TOBACCO habit.
A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.
Various fish of the family SALMONIDAE, usually smaller than salmon. They are mostly restricted to cool clear freshwater. Some are anadromous. They are highly regarded for their handsome colors, rich well-flavored flesh, and gameness as an angling fish. The genera Salvelinus, Salmo, and ONCORHYNCHUS have been introduced virtually throughout the world.
Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
A constellation of responses that occur when an organism is exposed to excessive heat. Responses include synthesis of new proteins and regulation of others.
A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
A family of nonbiting midges, in the order DIPTERA. Salivary glands of the genus Chironomus are used in studies of cellular genetics and biochemistry.
Complexes of RNA-binding proteins with ribonucleic acids (RNA).
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.
An order of the class Insecta. Wings, when present, number two and distinguish Diptera from other so-called flies, while the halteres, or reduced hindwings, separate Diptera from other insects with one pair of wings. The order includes the families Calliphoridae, Oestridae, Phoridae, SARCOPHAGIDAE, Scatophagidae, Sciaridae, SIMULIIDAE, Tabanidae, Therevidae, Trypetidae, CERATOPOGONIDAE; CHIRONOMIDAE; CULICIDAE; DROSOPHILIDAE; GLOSSINIDAE; MUSCIDAE; TEPHRITIDAE; and PSYCHODIDAE. The larval form of Diptera species are called maggots (see LARVA).
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Any method used for determining the location of and relative distances between genes on a chromosome.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Antibodies produced by a single clone of cells.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.

A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. (1/5)

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Balbiani ring mRNPs diffuse through and bind to clusters of large intranuclear molecular structures. (2/5)

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Nucleocytoplasmic mRNP export is an integral part of mRNP biogenesis. (3/5)

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The infant and pubertal human ovary: Balbiani's body-associated VASA expression, immunohistochemical detection of apoptosis-related BCL2 and BAX proteins, and DNA fragmentation. (4/5)

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The ecdysone receptor (ScEcR-A) binds DNA puffs at the start of DNA amplification in Sciara coprophila. (5/5)

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Vasa is an essential gene for germ cell development belonging to the DEAD-box family. In this study, we comparatively analyzed the expression characteristics of vasa in diploids, triploids, and tetraploids. The sequences showed high similarity among these fish and other vertebrates, with characteristic domains. Tissue expression analysis revealed that vasa was expressed exclusively in the gonad of different ploidy fishes. During embryogenesis, vasa expression was lower in diploid than in triploid and tetraploid fish, caused by doubling of the genome of tetraploids and abnormal gonads in the triploid fish. In adults, vasa mRNA levels were significantly lower in the testes of sterile triploid fish compared with fertile diploids and tetraploids. In the ovaries, triploid fish showed consistently high expression from the non-breeding season to the breeding season. Immunohistochemistry and western blotting results also supported the abnormal expression of vasa in triploid gonads. This study ...
We report here the molecular and cytological characterization of two proteins, ScoHET1 and ScoHET2 (for Sciara coprophila heterochromatin), which associate to constitutive heterochromatin in the dipteran S. coprophila. Both proteins, ScoHET1 of 37 kDa and ScoHET2 of 44 kDa, display two chromodomain motifs that contain the conserved residues essential for the recognition of methylated histone H3 at lysine 9. We raised antibodies to analyze the chromosomal location of ScoHET1 and ScoHET2 in somatic and germline cells. In S. coprophila polytene chromosomes, both proteins associate to the pericentromeric regions and to the heterochromatic subterminal bands of the chromosomes. In germinal nuclei, ScoHET1 and ScoHET2 proteins distribute to the heterochromatic regions of the regular chromosome complement and are abundantly present along the heterochromatic germline-limited
Balbiani ring (BR) granules are premessenger ribonucleoprotein particles (RNPs) generated in giant chromosomal puffs, the BRs, in the larval salivary glands of the dipteran chironomus tentans. Monoclonal antibodies were raised against nuclear proteins collected on a single-stranded-DNA-agarose affinity column, and two of them were used to identify RNA-binding proteins in BR granules. First, in Western blots (immunoblots), one of the antibodies recognized a 36-kDa protein and the other recognized a 45-KDa protein. Second, both antibodies bound to the BRs in immunocytological experiments. It was shown in cross-linking experiments that the two proteins are associated with heterogeneous nuclear RNP (hnRNP) complexes extracted from C. tentans nuclei. By immunoelectron microscopy of isolated and partly unfolded BR RNPs, it was specifically demonstrated that the BR granules contain the two proteins and, in addition, that both proteins are distributed frequently along the RNP fiber of the particles. ...
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List the changes the primary oocyte underqoes in the tertiary follicular stage in the human ovary - Biology - Human Reproduction
PUFF Meaning: short, quick blast; act of puffing, from puff (v.). Meaning type of light pastry is recorded from… See definitions of puff.
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The objective of our research is to determine whether the synchrotron is an effective tool for imaging human ovaries ex situ. Approximately 1 in every 6 women in Canada is affected by infertility; however, the underlying causes remain largely unknown. Imaging techniques are essential for increasing our understanding of normal and abnormal female reproductive biology. At present, ultrasonography is the most commonly-used tool to image human ovaries. However, ultrasonography only allows the detection of structures ≥ 2 mm in size within the ovaries, limiting the ability to detect smaller anatomic details (eg. the eggs and the surrounding cells and follicles or the small fluid filled sacs that contain the eggs). Other limitations of ultrasonography for imaging the ovaries include a limited depth of penetration within the pelvis and the inability to see the ovaries clearly due to bowel activity and/or gas.. The synchrotron has been effectively used for imaging soft tissues, including the breast, ...
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The cover image illustrates the relationship between βHeavy-spectrin (in green) and Coracle (in red) in the tubular Drosophila salivary gland epithelium. βH-spectrin is heavily concentrated at the apical lumenal surface, whereas Coracle is limited to the apical−lateral septate junctions at the cell boundaries. This image was made through a maximum projection of a confocal data stack. The boundary between these two domains is degraded in the absence of the βH-spectrin-binding protein Annexin B9. See Tjota et al. (pp. 2914-2926). ...
This little strange chick came with our other chicks that came with the momma hen, Freckles. The Amish people from which we got the chicks said that not all of them may have come from the momma hen, some other eggs may have gotten mixed in her nest. Sure enough, one little chick just doesnt look like the rest. All the chicks are about 2 months old, but this strange-looking little one, which I call Lil Puff, is much smaller and looks so different. Puff has a puff of feathers on her head, and a strange bumpy beak ...
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Hola..entry kedua untuk hari ini, ok, semalam my frens a.k.a my model yang sekarang jual barangan mekap datang menghantar barang yg emma ord ...
H. D. Berendes (1965). "Salivary gland function and chromosomal puffing patterns in Drosophila hydei". Chromosoma. 17 (1): 35- ...
Balbiani described the chromosomal puffs among the tangled thread inside the nucleus, and named it "permanent spireme". In 1890 ... The formation of puffs is called puffing. In the regions of puffs, the chromonemata uncoil and open out to form many loops. The ... The puffs indicate the site of active genes where mRNA synthesis takes place. The chromonemata of puffs give out a series of ... The chromosomal strands are formed after repeated division of the chromosome in the absence of cytoplasmic division. This type ...
Chromosomal changes induced by infective agents Triangle. Sandoz J. Med. Sci. vol. 8, p. 42-48. Pavan, C., Biesele, J., Riess, ... Since the early observations the giant polytene chromosomes and its puffs were noticed in several larval tissues. Similar ... The fly is scientifically notable for the physiology of its polytene chromosomes and developmentally regulated amplified puffs ... a transcription-related puff, where the chromatin expands and the transcription events takes place; and an amplification- ...
A unique feature of the hsromega gene, which led to discovery of the 93D puff in 1970, is its singular inducibility with ... Drosopoulou E, Konstantopoulou I, Scouras ZG (1996). "The heat shock genes in the Drosophila montium subgroup: chromosomal ... Lakhotia SC (2011). "Forty years of the 93D puff of Drosophila melanogaster" (PDF). Journal of Biosciences. 36 (3): 399-423. ...
PuFF) (ISS Experiment) - NASA Evaluation of Maximal Oxygen Uptake and Submaximal Estimates of VO2max Before, During, and After ... Chromosomal Aberrations in Blood Lymphocytes of Astronauts (Chromosome) Dosimetric Mapping (DOSMAP) A Study of Radiation Doses ... PuFF) Evaluation of Maximal Oxygen Uptake and Submaximal Estimates of VO2max Before, During, and After Long Duration ... NASA Chromosomal Aberrations in Blood Lymphocytes of Astronauts (Chromosome) (ISS Experiment) - NASA Dosimetric Mapping (DOSMAP ...
Stowers RS, Garza D, Rascle A, Hogness DS (2000). "The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes ... This second definition is also sometimes applied to the situation where two different chromosomal deletions exist in trans (on ...
Poppy seeds are cancer presenters (blocking 80% of the chromosomal damage in carcinogen). Spices have a high amount of ... prominent predators who signal another by puffing out their throats and expanding their chests to show their radiant colour ...
Males and females flare or puff out their gill covers (opercula) to appear more impressive, either to intimidate other rivals ... Currently, the complete B. splendens chromosomal and mitochondrial genomes have been sequenced. Both genomes have yet to be ...
... studied chromosomal basis of sex and discovered XY basis Miodrag Stojković (born 1964), Serbian geneticist, working in Europe ... French embryologist who found chromosome puffs now called Balbiani rings David Baltimore (born 1938), US biologist, Nobel Prize ... elucidated chromosomal crossover Charles Darwin (1809-1882), English naturalist and author of On the Origin of Species Kay ... US botanist who with McClintock first saw chromosomal crossover Francis Crick (1916-2004), English molecular biologist, ...
After a puff, inhalation of the aerosol travels from the device into the mouth and lungs. The composition of e-liquids varies ... Nicotine has been shown to induce chromosomal aberration, chromatid exchange, single-strand DNA strand breaks, and micronuclei ... Fifteen puffs were chosen to estimate the nicotine delivery of one traditional cigarette. The risks to the lungs are not fully ... Users detect the "dry puff" (also known as a "dry hit") and avoid it, and they concluded that "There is no indication that EC ...
Some of the maize chromosomes have what are known as "chromosomal knobs": highly repetitive heterochromatic domains that stain ... the puffed confection known as popcorn and the breakfast cereal known as corn flakes.[citation needed] In Southern Africa, ... There are about 1000 chromosomal aberrations (e.g., translocations and inversions) and stocks with abnormal chromosome numbers ...
Over evolutionary time scales in which chromosomal polymorphisms accumulate, these changes become less apparent by karyotype - ... "Genes involved in tissue and organ development: Polytene chromosomes, endoreduplication and puffing". The Interactive Fly. ...
Some of the maize chromosomes have what are known as "chromosomal knobs": highly repetitive heterochromatic domains that stain ... the puffed confection known as popcorn and the breakfast cereal known as corn flakes. ... There are about 1000 chromosomal aberrations (e.g., translocations and inversions) and stocks with abnormal chromosome numbers ...
Instead, it puffs out its throat and draws air in through the nostrils, which in many species can then be closed by valves. ... evidence from studies on rates of chromosomal, protein, and anatomical evolution". Proceedings of the National Academy of ...
Renk K, White R, Lauer BA, McSwiggan M, Puff J, Lowell A (February 2014). "Bipolar Disorder in Children". Psychiatry J. 2014 ( ... Behavioral genetic studies have suggested that many chromosomal regions and candidate genes are related to bipolar disorder ...
In modern times, Sugar Puff, who had been listed in Guinness World Records as the world's oldest living pony, died in 2007 at ... "Horse Domestication and Conservation Genetics of Przewalski's Horse Inferred from Sex Chromosomal and Autosomal Sequences". ...
Sugar Puff, who had been listed in Guinness World Records as the world's oldest living pony, died in 2007 at age 56.[9] ... "Horse Domestication and Conservation Genetics of Przewalski's Horse Inferred from Sex Chromosomal and Autosomal Sequences". ...
Chromosomal Puffs. publications Timeline , Most Recent This graph shows the total number of publications written about " ...
1974) Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol 84:389-398, ... Chromosomal and Muscle Forms of Titin. The chromosomal and muscle forms of titin are unlikely to be identical. Although both ... 1994) Role of nonhistone proteins in the chromosomal events of mitosis. FASEB (Fed Am Soc Exp Biol) J 8:947-956, pmid:8088460. ... 1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91:47-58, pmid:9335334.. ...
H. D. Berendes (1965). "Salivary gland function and chromosomal puffing patterns in Drosophila hydei". Chromosoma. 17 (1): 35- ...
Balbiani described the chromosomal puffs among the tangled thread inside the nucleus, and named it "permanent spireme". In 1890 ... The formation of puffs is called puffing. In the regions of puffs, the chromonemata uncoil and open out to form many loops. The ... The puffs indicate the site of active genes where mRNA synthesis takes place. The chromonemata of puffs give out a series of ... The chromosomal strands are formed after repeated division of the chromosome in the absence of cytoplasmic division. This type ...
Associates with open chromatin and chromosomal puffs of polytene chromosomes in larval salivary glands (PubMed:21752937). ...
As DNA decondenses into a more open state, it forms a distinctive swelling known as a chromosomal puff. These puffs are active ... Thus, chromosomal DNA is organized as a string of nucleosome beads with a small amount of DNA connecting each bead. This first ... Finally, the chromosomal binding site is determined by way of a procedure called autoradiography, which is used to make the ... In the Drosophila polytene chromosomes, this disruption can be seen, at least in part, as puffs at sites of DNA replication. It ...
PARP1 is an important regulator of transcription, as can be seen at PAR-rich Drosophila chromosomal "puffs" undergoing active ... Tulin, A.; Spradling, A. Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at drosophila puff loci. Science 2003, 299, ... polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res. 2002, 62, 6990-6996. [Google Scholar] ...
Chromosomal rearrangements are easily documented by comparing the order of bands between individuals, lines or even species. ... Puffs then, afford a view of the temporal sequence of gene activation. A temporal pattern to puffing in the salivary glands of ... Early puffs are independent of protein synthesis while late puffs require prior protein synthesis (Ashburner, 1990). For more ... Puffing is the term that describes structural changes in polytene chromosomes. If one observes polytene chromosomes during the ...
Staining was observed in some chromosomal puffs, suggesting that cohesin associates with transcribed loci. To test this, it was ... Nevertheless, individual chromosome tips could be identified, and developmental puffs, including the puff at 2B, were present ... Salivary glands do not express cut, but because cohesin is a constitutive chromosomal component, and probably binds to cut in ... Based on the assumption that cohesin is a constitutive chromosomal component, and the finding that it binds to the cut locus in ...
All experiments were carried out using a smoking machine with two ECs at different puff rate(s), 1 puff and 2 puffs per min, ... Acetaldehyde induced DNA and chromosomal damage in human lymphocyte in vitro [35, 36, 37]. Our findings are consistent with ... When stratified by puffing time, 2 puffs/min produced a significantly higher PNC than 1 puff/min for the menthol-flavored ECs ( ... tobacco flavor, 1 puff vs. 2 puffs) were tested using Students t-test. In addition, linear regressions were applied to ...
Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans NATURE Roy, P. J., Stuart, J. M., Lund, J., Kim, S. ... Classic examples of open chromatin domains include puffs on polytene chromosomes in Drosophila and extended loops from ... Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C-elegans DEVELOPMENT Pauli, F., Liu ... To investigate whether co-expressed genes are clustered, we examined the chromosomal positions of the genes expressed in the ...
... and trace elements by flavor and puffing time. We used ECs containing a common nicotine strength (1.8%) and the most popular ... All experiments were carried out using a smoking machine with two ECs at different puff rate(s), 1 puff and 2 puffs per min, ... Acetaldehyde induced DNA and chromosomal damage in human lymphocyte in vitro [35-37]. Our findings are consistent with those ... When stratified by puffing time, 2 puffs/min produced a significantly higher PNC than 1 puff/min for the menthol-flavored ECs ( ...
Loss of NURF function causes local chromosomal puffing at these same transgene insertion sites (B and D, arrows), and X- ... B) Similarly, puffing of the distal X including the roX1 locus is lost when roX1 is deleted. The genotypes are (A) yw Df (1) ... However, regional puffing can still be seen in most of the mutants (Figure 1, C and D), suggesting that there may be some sites ... The local puffing on the X chromosome in Nurf301 mutants prompted us to examine whether roX genes could modulate the Nurf301 ...
After prolonged heat shock, all Sxl protein was restricted to the heat-induced puff at the hs93D locus. In contrast, a ... Anti-Sxl staining of polytene chromosomes showed Sxl protein at a number of chromosomal locations, among which was the Sxl ... Sxl protein could also be targeted to a new chromosomal site carrying a transgene containing splicing regulatory sequences from ... presumptive small nuclear RNP protein was observed at several heat puffs following shock. ...
... chromosome puff explanation free. What is chromosome puff? Meaning of chromosome puff medical term. What does chromosome puff ... Looking for online definition of chromosome puff in the Medical Dictionary? ... Such bands appear at certain chromosomal locations within a given tissue at specific developmental stages in insects and are ... chromosome puff. Also found in: Dictionary, Thesaurus, Legal, Encyclopedia. chromosome puff. a band of accumulated chromatin ...
This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. ...
1996) Sodium salicylate decreases intracellular ATP, induces both heat shock factor binding and chromosomal puffing, but does ...
... we studied the binding of the antibodies to chromosomal puffs in general. It was observed that many puffs in addition to the ... Balbiani ring (BR) granules are premessenger ribonucleoprotein particles (RNPs) generated in giant chromosomal puffs, the BRs, ... BRs harbor the two proteins, but there are also puffs containing only one of the components, either the 36- or the 45-kDa ...
By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary gland, Drosophila DEK ( ... In some human myeloid leukemia patients, DEK was fused to CAN by chromosomal translocation. This mutation significantly reduced ... dDEK facilitated H3.3 assembly during puff formation. ...
Who would have predicted the chance observation of Ritossas that chromosomal puffs in Drosophila, induced by elevated ... Ritossas "heat shock" puffs, which by light microscopy looked like cotton balls compressed between sections of tightly packed ... Ritossas "heat shock" puffs, which by light microscopy looked like cotton balls compressed between sections of tightly packed ... However, it was the demonstration that these puffs were new sites of transcription that was most impressive-Ritossa could ...
"Effect of bisacylhydrazine ecdysteroid mimics (RH-5849 and RH-5992) on chromosomal puffing, imaginal disc proliferation and ...
... suggesting that a chromosomal domain consists of a band (or puff) and part of the flanking interbands. Enhancer blocking assays ... Visualization of chromosomal domains with boundary element-associated factor BEAF-32 Cell. 1995 Jun 16;81(6):879-89. doi: ... Immunostaining localizes BEAF to hundreds of interbands and many puff boundaries on polytene chromosomes, ...
... in the manner which is very similar to sequential gene activation in chromosomal puffs. Experiments with the withdrawal of ... thus proving the existence of parallel mechanism controlling induction of specific chromosomal puffs and transcription of rDNA ...
Homology of puffing patterns on chromosome arm 3L in D.. Descripcion del kariotipo de Mayetiola hordei (Diptera: Cecidomyiidae ... Banding patterns of three leafcutter ant species of the genus Atta (Formicidae: Myrmicinae) and chromosomal inferences ...
To test this, researchers taught normal mice to associate a short light signal with a puff of air to the eye. The mice learned ... the human 15q11-13 chromosomal duplication. They focused on the cerebellum, a brain region heavily involved in motor control. ... Purkinje cells receive signals about environmental errors or disturbances - such as an air puff reaching the eye - from ... to blink in response to the light, even without an air puff. ASD model mice, however, were much slower to learn in this eye ...
Chromosomal Puffs. Chromosomes, Insect. Nematocyst. Neural Stem Cells Polytene Chromosome Sensilla. Category B - Organisms. ...
... chromosome puffing and hormonal control in development, chromosomal anomalies, gene linkage, pharmacogenetics, genetic ...
BR1, BR2, BR3, BR4: Balbiani rings, P: puff. Mentions: As a whole, the morphology of the salivary glands was similar to those ... 4). The combination of chromosomal arms was AB, CD, EF and G. Chromosomes were denominated from their respective lengths: I=II, ... 4). The combination of chromosomal arms was AB, CD, EF and G. Chromosomes were denominated from their respective lengths: I=II, ...
... both puffs and loci identified as puffing at some time during the third instar and prepupal period. In larvae that were heat ... Monoclonal antibodies against a specific nonhistone chromosomal protein of Drosophila associated with active genes. G C Howard, ... G C Howard, S M Abmayr, L A Shinefeld, V L Sato, S C Elgin; Monoclonal antibodies against a specific nonhistone chromosomal ... The results verify the hypothesis that a specific nonhistone chromosomal protein is preferentially associated with the set of ...
  • The bands of polytene chromosomes become enlarged at certain times to form swellings called puffs. (wikipedia.org)
  • Puffing is the term that describes structural changes in polytene chromosomes. (sdbonline.org)
  • If one observes polytene chromosomes during the late prepupal stage, different bands appear to be puffed up. (sdbonline.org)
  • Anti-Sxl staining of polytene chromosomes showed Sxl protein at a number of chromosomal locations, among which was the Sxl locus itself. (asm.org)
  • Ritossa's "heat shock" puffs, which by light microscopy looked like cotton balls compressed between sections of tightly packed chromosomes, were also induced by exposure to dinitrophenol, ethanol, and salicylate. (nutritionreview.org)
  • Immunostaining localizes BEAF to hundreds of interbands and many puff boundaries on polytene chromosomes, suggesting that a chromosomal domain consists of a band (or puff) and part of the flanking interbands. (nih.gov)
  • A technique used to identify the presence of specific chromosomes or chromosomal regions through hybridization (attachment) of fluorescently-labeled DNA. (gofastdepot.com)
  • We know he has what is called a chromosomal translocation - his chromosomes are all there, but they're arranged differently. (thefreedictionary.com)
  • It was a chromosomal mosaic with 2n = 103 to 151 chromosomes. (thefreedictionary.com)
  • We found that treatment ofBradysia hygida larvae with BrdUrd during DNA puff anlage formation in the polytene chromosomes of the salivary gland S1 region noticeably affects anlage morphology. (bvsalud.org)
  • These include puffing of transcriptionally active regions of polytene chromosomes (e.g. (biologists.org)
  • C., as well as exposure to certain chemicals such as dinitrophenol or sodium salicylate, leads to a remarkable change in the puffing pattern of polytene chromosomes in salivary glands of fruit flies (Drosophila hydei). (justia.com)
  • In polytene chromosomes, condensed (bands), decondensed (interbands), genetically active (puffs), and silent (pericentric and intercalary heterochromatin as well as regions subject to position effect variegation) regions were found and their features were described in detail. (elsevier.com)
  • Classic" polytene chromosomes from larval salivary glands of D. melanogaster are composed of bundles of one to two thousand tightly synapsed chromosomal strands, which are formed via multiple rounds of endoreplication of just two starting chromatids. (biomedcentral.com)
  • Chromosomal Theory of Inheritance Genes are physically located at loci on chromosomes Additionally, it is chromosomes . (slideplayer.com)
  • The identification of titin as a chromosomal component provides a molecular basis for chromosome structure and elasticity. (rupress.org)
  • The chromosomal strands are formed after repeated division of the chromosome in the absence of cytoplasmic division. (wikipedia.org)
  • however, these position effects can be reversed by chromosomal rearrangements that bring the rolled gene closer to any block of autosomal or X chromosome heterochromatin (Eberl, 1993). (sdbonline.org)
  • Chromosome puffs contain DNA and RNA and are thought to represent gene TRANSCRIPTION . (thefreedictionary.com)
  • Discovered in 1962 by Ferruccio Ritossa, the heat shock response was described as the temperature-induced change in the organization of the tightly packed Drosophila salivary gland chromosome, leading to the appearance of puffs. (nutritionreview.org)
  • Homology of puffing patterns on chromosome arm 3L in D. (thefreedictionary.com)
  • Chromosome 10 was frequently involved in chromosomal translocation , which may be catastrophic genomic events and play key roles in tumorigenesis. (thefreedictionary.com)
  • Dr. Yu also received a two-year, $229,947 subcontract from Moffitt Cancer Center to model sarcoma-associated chromosomal translocations using chromosome engineering and then employ imaging analysis to identify different tumor habitats in the models, as part of a larger NCI-funded effort. (roswellpark.org)
  • chromosomal ( adjective , of or pertaining to the chromosome). (biology-online.org)
  • Using a human autoimmune scleroderma serum that identifies a chromosomal protein in human cells and Drosophila embryos, we cloned the corresponding Drosophila gene that encodes the homologue of vertebrate titin based on protein size, sequence similarity, developmental expression and subcellular localization. (rupress.org)
  • Using this serum to screen a Drosophila expression library, we isolated the gene that encodes the chromosomal protein that proved to be the Drosophila homologue of vertebrate titin ( D-Titin ). (rupress.org)
  • Monoclonal antibodies against a specific nonhistone chromosomal protein of Drosophila associated with active genes. (rupress.org)
  • Data are presented of electron microscopic (EM) analysis of consecutive developmental stages of Drosophila melanogaster complex puffs, formed as a result of simultaneous decondensation of several bands. (springernature.com)
  • The biological relevance of molecular chaperones during the modern times was discovered during the early 1960s when the Italian scientist Ferruccio Ritossa was studying nucleic acid synthesis in puffs of Drosophila salivary glands. (benthamscience.com)
  • Balbiani ring (BR) granules are premessenger ribonucleoprotein particles (RNPs) generated in giant chromosomal puffs, the BRs, in the larval salivary glands of the dipteran chironomus tentans. (asm.org)
  • The chromatin of the chromosomal sites that would normally form DNA puffs remains very compact and DNA puff expansion does not occur with administration of 4 to 8 mM BrdUrd. (bvsalud.org)
  • Injection of BrdUrd at different ages provoked a gradient of compaction of the DNA puff chromatin, leading to the formation of very small to almost normal puffs. (bvsalud.org)
  • We propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff. (creedmoon.fun)
  • Subsequently chromatin boundaries (insulators) were discovered to flank the heat shock puffs. (elsevier.com)
  • proteins, separated by size In addition, chromatin contains an approximately equal mass of a wide variety of non-histone chromosomal proteins. (slideplayer.com)
  • 1991 ) Position-effect variegation-an assay for nonhistone chromosomal proteins and chromatin assembly and modifying factors. (biologists.org)
  • To investigate, Hansel and his team utilized a mouse model for one of the most common genetic abnormalities known in autism, the human 15q11-13 chromosomal duplication. (eurekalert.org)
  • Bidi rolling is associated with chromosomal abnormalities 19 . (mdquit.org)
  • But in fact, most miscarriages are the result of chromosomal abnormalities in the developing fetus, structural abnormalities of the uterus, or endocrine or autoimmune disorders in the moth. (medworm.com)
  • This method requires fair expertness in fluorescent in situ hybridization techniques as warm-heartedly as expertise in the simplification of the chromosomal abnormalities. (betsystamant.com)
  • Pre-implantation genetic diagnosis (PGD) is used in fertility clinics to detect large chromosomal abnormalities or genetic mutations passed on by parents to their in vitro fertilized (IVF) embryos. (bionity.com)
  • BR - Balbiani Ring, p - puff, arrows show centromeric bands. (nih.gov)
  • To elucidate to what extent the two proteins are also present in other hnRNPs, we studied the binding of the antibodies to chromosomal puffs in general. (asm.org)
  • It was observed that many puffs in addition to the BRs harbor the two proteins, but there are also puffs containing only one of the components, either the 36- or the 45-kDa protein. (asm.org)
  • The antigen for clone 28 was identified as a single protein of approximately 62,000 mol wt by using the antibodies followed by 125I-rabbit anti-mouse Ig to stain nitrocellulose replicas of SDS polyacrylamide gels of total chromosomal proteins. (rupress.org)
  • They are also exploring whether UBE3A , an autism candidate gene located in the 15q11-13 chromosomal region, is involved in synaptic pruning. (spectrumnews.org)
  • or chromosomal aberrations, or even broken. (zeroweb.org)
  • DSBs have been proven to be a key damage at a molecular level responsible for the formation of chromosomal aberrations, leading often to cell death. (spiedigitallibrary.org)
  • From a biochemical perspective, the normal growth and reproduction of bacteria nucleic acid (RNA) and deoxyribonucleic acid (DNA) is closely connected to the curl macromolecules by the number of hydrogen bonds, microwave cause hydrogen bonds the slack, breaking and reorganization, and induce genetic gene or chromosomal aberrations, or even broken. (zeroweb.org)
  • In addition, the microwave can make the bacteria normal growth and stability of the genetic breeding nucleic acid [RNA] and DNA [DNA], relaxation by a number of hydrogen bonds, breaking and reorganization, which induce genetic mutations or chromosomal aberrations and even rupture. (evangelicaloutpost.com)
  • The results verify the hypothesis that a specific nonhistone chromosomal protein is preferentially associated with the set of loci that includes both active sites and those scheduled to be active at some time in this developmental program. (rupress.org)
  • The puffs indicate the site of active genes where mRNA synthesis takes place. (wikipedia.org)
  • These include immunological approachesthoertrans- fer of tumor Binary options trading vs forex genes or prodrug-activating en- zymes. (4gamers-market.ru)
  • Puffs then, afford a view of the temporal sequence of gene activation. (sdbonline.org)
  • Sxl protein could also be targeted to a new chromosomal site carrying a transgene containing splicing regulatory sequences from the Sxl gene, following transcriptional induction. (asm.org)
  • This idea is reinforced by the fact that such puffs occur at regular intervals, suggesting that GENE SWITCHING is in operation. (thefreedictionary.com)
  • In the case of clone 28, the antibodies showed a preferential association with sites of gene activity, both puffs and loci identified as puffing at some time during the third instar and prepupal period. (rupress.org)
  • In studies of sequential puff formation it was found for the first time that the steroid hormone (ecdysone) exerts its action through gene activation, and that the process of gene activation upon ecdysone proceeds as a cascade. (elsevier.com)
  • This is manifested most clearly in case of puffing, i.e. when upon gene activation bands form puffs. (biomedcentral.com)
  • Autoradiographic experiments and silver grains counting showed that this treatment decreases the efficiency of RNA synthesis at DNA puff anlages. (bvsalud.org)
  • EM mapping principles proposed by us permitted more exact determination of the banding patterns of 19 regions in which 31 puffs develop. (springernature.com)
  • Molecular analysis and immunostaining with antibodies to multiple titin epitopes indicates that the chromosomal and muscle forms of titin may vary in their NH 2 termini. (rupress.org)
  • In protozoans, there is no transcription, since the puff consists only of DNA. (wikipedia.org)
  • However, it was the demonstration that these puffs were new sites of transcription that was most impressive-Ritossa could detect newly synthesized RNA within minutes of puffing. (nutritionreview.org)
  • By immunodetection, we show that the analogue is preferentially incorporated into the DNA puff anlages. (bvsalud.org)
  • The signature molecular abnormality of synovial sarcoma consists of a balanced chromosomal translocation t(X;18)(p11;q11) that results in an in-frame fusion of SS18 to SSX1, SSX2, or in rare instances, SSX4. (thefreedictionary.com)
  • It however wasn't viable for transfer due to a chromosomal abnormality. (dooleynotedstyle.com)
  • In the regions of puffs, the chromonemata uncoil and open out to form many loops. (wikipedia.org)
  • In the 50CF, 62CE, 63F and 71CF regions puffing zones are located closely adjacent to each other but the decondensation of separate band groups occurs at different puff stages (PS). (springernature.com)
  • genome detected multiple genetic exchanges between pericentromeric regions of chromosomal arms caused by partial-arm translocations. (g3journal.org)
  • The puffing is caused by the uncoiling of individual chromomeres in a band. (wikipedia.org)
  • a growing knowledge that a significant percentage of embryos are chromosomal mosaics at this stage--a phenomenon that likely results in nontransfer of embryos that have the potential for developing karyotypically normally. (thefreedictionary.com)
  • Thus far, effects associated with UPD have included disorders of genomic imprinting, chromosomal imbalances, recessive disorders through isodisomy, pheno- copies of some chromosomal deletions, and a possible contribution to the stepwise development of the oncogenic process (Engel, 1993. (retzepti.ru)
  • Thus, chromosomal DNA is organized as a string of nucleosome beads with a small amount of DNA connecting each bead. (encyclopedia.com)
  • After prolonged heat shock, all Sxl protein was restricted to the heat-induced puff at the hs93D locus. (asm.org)
  • In contrast, a presumptive small nuclear RNP protein was observed at several heat puffs following shock. (asm.org)
  • The morphological data obtained suggest a complex genetic organisation of many puffs. (springernature.com)
  • Chromosomal rearrangements are easily documented by comparing the order of bands between individuals, lines or even species. (sdbonline.org)
  • Such bands appear at certain chromosomal locations within a given tissue at specific developmental stages in insects and are significant in the study of the mode of genetic transmission. (thefreedictionary.com)
  • Hansel and his team studied motor circuits in the cerebellums of mice with an extra copy of the chromosomal region 15q11-13 - thought to be the second most common genetic aberration seen in autism . (spectrumnews.org)
  • Basic semen analysis of the male patient and the fact that he had previously fathered a healthy child indicated that his fertility was not affected by his chromosomal translocation , contrary to previous literature reports stating that male balanced translocations carriers are prone to sterility. (thefreedictionary.com)
  • For permanent and inheritable genetic modification, such as those processes used for crop engineering, chromosomal modifications are used. (rdxplanet.com)
  • Three cases of two-band puff formation when one or both bands undergo partial decondensation are described. (springernature.com)
  • When BrdUrd is injected in a mixture with thymidine, it is not incorporated into the DNA, and normal DNA puffs form. (bvsalud.org)
  • We aimed to assess the content of electronic cigarette (EC) emissions for five groups of potentially toxic compounds that are known to be present in tobacco smoke: nicotine, particles, carbonyls, volatile organic compounds (VOCs), and trace elements by flavor and puffing time. (springer.com)
  • Results from the Collaborative Genetic Study of Nicotine Dependence show that of 53,742 screened subjects, roughly half (51 percent) took at least one puff on a cigarette. (drugabuse.gov)
  • 5) The myxoid variant, which is characterized by the chromosomal translocation t(12;16) (q13;p11), is a lobulated soft-tissue tumor composed of slender, hyperchromatic spindle cells and signet-ringlipoblasts, a plexiform vascular pattern, and a myxoid matrix. (thefreedictionary.com)
  • To test this, researchers taught normal mice to associate a short light signal with a puff of air to the eye. (eurekalert.org)
  • The mice learned to blink in response to the light, even without an air puff. (eurekalert.org)
  • The researchers used a test called 'eye-blink conditioning,' in which mice learn to associate a shining light with an uncomfortable puff of air on their eye. (spectrumnews.org)
  • Using Retin A means changing most of the products that are used for cleaning and protecting the skin and this inclludes CLarisonic, proventil inhaler time between puffs toners, and scrubs. (rdxplanet.com)
  • It was amazing, John was able to join me in the "OR" and We saw a little puff of light pop on the ultrasound screen letting us know the embryo made its way nto my belly. (dooleynotedstyle.com)
  • Cervarix vaccine prevents cervical cancer and in whom hardware removal is o en an overlooked site o the greats, i traditional neurologists were botanists who knew the rare and fastidious bacteria. (roanokechowan.edu)