Chromosomal Position Effects

Eye Color

Chromosome Mapping

Chromosomes

Transgenes

JIL-1 and Su(var)3-7 Interact Genetically and Counteract Each Others Effect on Position-Effect Variegation in Drosophila |...

Deleteriousness scores show different position effects | Open-i

BacMap

Transcription factories and chromosome structure - Oxford Neuroscience

How to use bcftools to extract chromosomal position and genotypes?

Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and...

Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood | Epigenetics &...

Position effects on eukaryotic gene expression. - Department of Physiology, Anatomy and Genetics (DPAG)

How do geneticists indicate the location of a gene?

欧洲垃圾和污水处理标准(EN)翻译目录查询

A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7

3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers - Week 3 - Dosage Compensation |...

PreCisIon: PREdiction of CIS-regulatory elements improved by genes positION. - PubMed - NCBI

Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. - PubMed - NCBI

JoVE Author Search: Elgin SC

In vivo live imaging of RNA polymerase II transcription factories in primary cells. - Radcliffe Department of Medicine

Effect of Nicotinamide in Friedreich's Ataxia - Full Text View - ClinicalTrials.gov

Effect of Nicotinamide in Friedreich's Ataxia - Full Text View - ClinicalTrials.gov

Human Nucleome Reveals Amazing 4-D World | The Institute for Creation Research

Biology-Online • View topic - Traslocation

Power Calibration Area Error - Chat - ImgBurn Support Forum

David Le Monnier

ERIC - EJ1285608 - Academic Rank and Position Effect on Academic Research Output -- A Case Study of Ariel University,...

Genomic imprinting of chromatin in Drosophila melanogaster

Variegation - Wikipedia

Welcome to Xcelris Genomics

Rob Martienssen - Cold Spring Harbor Laboratory

The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression. - Inserm

Photosynthetic Redox Imbalance Governs Leaf Sectoring in the Arabidopsis thaliana Variegation Mutants immutans, spotty, var1,...

Supplementary Materials Supplemental Textiles (PDF) JCB 201601050 sm - Human Cytomegalovirus Inhibition by Cardiac Glycosides

Epigenetic inheritance of gene expression in ciliates | Ciliate-net

Studies of rearrangements involving heterochromatin in Drosophila melanogaster. I. A proof of variegated-type position effect...

A Correlation of Ring-Shaped Chromosomes with Variegation in Zea Mays (December 15, 1932)

AKC Canine Health Foundation

The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in...

China Virgin TPR/TPE/TPV Granules/Pellets TPE Raw Material Virgin TPE Granules - China Tr Raw Material/TPR Granule for Shoes...

Artificial Ficus Tree With Variegation Leaves 2m - JNR-Studio

Cp190 - Centrosome-associated zinc finger protein CP190 - Drosophila melanogaster (Fruit fly) - Cp190 gene & protein

Silencing DNAmet-imprin 2012

Localization of Sir2p: the nucleolus as a compartment for silent information regulators | The EMBO Journal

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional...

Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood. - TUbiblio

Kenyas Ballot Scars - allAfrica.com

Matthew Zook

TPE 2003 - Anti-Fogging

TPE Male Sex Doll Blond Jimmy 5ft 2 (160 cm) | Naughty Harbor

WERAM - Writers, Erasers & Readers of Histone Acetylation and Methylation Database

Suv420h1 (untagged) - Mouse suppressor of variegation 4-20 homolog 1 (Drosophila) (Suv420h1), transcript variant 5, (10ug) -...

Gabrîyêl - Medium

Proteins: Recombinant, Native & Peptides | Cell Sciences

Insulated neighborhood

Abby Dernburg

Biodiversity

Position-effect variegation

Limb bud

RASGRP1

BESS domain

Hally Jolivette Sax

Position effect

Sarah Elgin

Glossary of genetics

Lawrence B. Salkoff

Intragenomic conflict

RpoS

Apical ectodermal ridge

Microevolution

Marginal zone B-cell lymphoma

Z-DNA

Subtelomere

Matilda effect

RIOK1

Netrin receptor DCC

Microbeam

SALL1

Recombinant inbred strain

MYH9

Thomas Hunt Morgan

Chromatin bridge

INPP1

Lavender (chicken plumage)

Genes10

• Even if all genes remain intact after a chromosomal break, serious problems may occur. (mpg.de)
• The team examined clinical samples from blood, skin and amniotic fluid of nine patients with chromosomal breaks but without damage to known genes. (mpg.de)
• One such regional dependency is the telomeric effect, observed in several studies of Saccharomyces cerevisiae, under which e. g. essential genes are less likely to reside near the chromosomal ends. (chalmers.se)
• Can environmental factors modify the effect of genes influencing blood pressure? (unil.ch)
• The problem is particularly challenging in populations with significant linkage disequilibrium, where traits are often linked to large chromosomal regions containing many genes. (nih.gov)
• UCOE® technology expression elements are small DNA elements (isolated from around house-keeping genes, which need to be active most of the time) which create a transcriptionally active open chromatin environment around an integrated transgene, maximizing its potential to be transcribed into protein irrespective of the position of the transgene in the chromosome. (emdmillipore.com)
• The effects on gene expression that depend on the location of a gene with respect to its neighboring genes and region of chromosome. (bvsalud.org)
• Characterization of two genes required for the position-effect control of yeast mating-type genes. (ox.ac.uk)
• Chromosomal distribution of genes, are required for statistical testing of this hypothesis point, ligament, peritendon region, perineural region and the epidural space. (lotusseedsdesign.com)
• Telomeres are also implicated in transcriptional reversible gene silencing of nearby genes, leading to telomere position effect (TPE), which can promote modifications in cell biology. (fapesp.br)

Chromosome6

• The researchers applied a method called 'Hi-C' (High-throughput Chromosome Conformation Capture) to samples from patients with developmental disorders suspected to be caused by chromosomal rearrangements. (mpg.de)
• The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 11. (medlineplus.gov)
• Complex chromosome rearrangements (CCRs) are structural chromosomal rearrangements involving at least three chromosomes and more than two breakpoints. (e-kjgm.org)
• Based on the motion behaviors of the chromosome locus pair, the relaxation and the reorganization of the local chromosomal segments have been qualitatively and quantitatively resolved. (ntnu.edu.tw)
• The regional spatial shift to the cell membrane and the more significant changes of the correlated motion suggest the existence of the membrane-involved influence on the local chromosomal segments in the membrane protein expression, and it can be a key factor to segregate the whole bacterial chromosome. (ntnu.edu.tw)
• This chromosomal alteration only affects female individuals, who have monosomy of the X chromosome. (bvsalud.org)

Chromosomes4

• The classical analysis of chromosomal defects is done by a karyogram, which is a microscopic view of stained chromosomes. (mpg.de)
• Interpretation of statistical tests based on these assumptions may be misleading if dependencies exist that are unequal between chromosomes or in different chromosomal parts. (chalmers.se)
• The parent carries a chromosomal rearrangement between chromosomes 11 and 22 called a balanced translocation. (medlineplus.gov)
• With this approach, we demonstrate that transposons engage in long-range intra-chromosomal interactions guided by the separation of chromosomes into A and B compartments as well as topologically associated domains (TADs). (springer.com)

Abnormalities2

• This is despite the increased risk of chromosomal abnormalities and complications of pregnancy in this age group. (bmj.com)
• Epidemics of both genetic and chromosomal abnormalities. (berea.edu)

Gene expression8

• Here, we present a novel method, Lirnet, that automatically learns a regulatory potential for each sequence polymorphism, estimating how likely it is to have a significant effect on gene expression. (nih.gov)
• The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl.de)
• Ubiquitous Chromatin Opening Element (UCOE®) technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. (emdmillipore.com)
• UCOE® technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site. (emdmillipore.com)
• UCOE technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. (emdmillipore.com)
• UCOE technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site yielding 20-fold higher protein expression levels than conventional vectors. (emdmillipore.com)
• Cell to cell variation in gene expression caused by chromosomal position effects. (bvsalud.org)
• To reveal the details of the effect induced by the gene expression, the positions and the motions of the local chromosomal segments around the lactose operon have been investigated. (ntnu.edu.tw)

Rearrangement2

• About 1 percent of all people with Beckwith-Wiedemann syndrome have a chromosomal abnormality such as a rearrangement (translocation) involving 11p15.5 or abnormal copying (duplication) or deletion of genetic material in this region. (medlineplus.gov)
• The reason for the retinitis pigmentosa phenotype in patient BB remains unclear, but the most likely explanations include a long-range chromosomal position effect, a small secondary rearrangement, and the presence of a coincident autosomal form of retinitis pigmentosa. (abertay.ac.uk)

Rearrangements4

• Chromosomal rearrangements may alter these interaction patterns and can thus be seen in the analysis. (mpg.de)
• The interaction at eya is essentially identical to a phenomenon known as transvection, which is an allelic position effect that is sensitive to certain kinds of chromosomal rearrangements. (caltech.edu)
• Because chromosomal rearrangements can affect the genotype-phenotype map of individuals and thus modify the patterns of covariation between traits, we also evaluate the effect of Robertsonian translocations on the modularity pattern of the sperm head. (biomedcentral.com)
• The reduction in percentages of shape covariation between pairs of modules in Rb sperms suggests that chromosomal rearrangements could induce changes in the genotype-phenotype map. (biomedcentral.com)

Proteins1

• His research focused on the molecular biology of chromosomal proteins. (uga.edu)

Drosophila4

• Based on sequence information from the SET domain, we have isolated human (SUV39H1) and mouse (Suv39h1) homologues of the dominant Drosophila modifier of position-effect-variegation (PEV) Su(var)3-9. (embl.de)
• First detection of chromosomal inversions in a natural population of the invasive pest species Drosophila suzukii . (ub.edu)
• Chromosomal Thermal Index: a comprehensive way to integrate the thermal adaptation of Drosophila subobscura whole karyotype" Genome 61: 73-78. (ub.edu)
• Medium-term changes in Drosophila subobscura chromosomal inversion polymorphism: a possible relation with global warming? (ub.edu)

Mutation1

• The mutation does, however, affect CP190 recruitment to specific insulator elements and has a modest effect on CTCF chromatin association. (sdbonline.org)

Epigenetic2

• Some of these epimutations, termed secondary, correspond to the epigenetic effects of cis -acting genetic defects transmitted to the offspring following a Mendelian inheritance pattern. (nature.com)
• 2 primary epimutations corresponding to pure epigenetic events, labile in the germ line and thus reversible between generations (although non-Mendelian inheritance might be occasionally observed 11 ), and secondary epimutations corresponding to the secondary epigenetic effects of cis -acting genetic alterations transmitted following a Mendelian inheritance pattern, with re-establishment of the epigenetic change in the offspring. (nature.com)

Loci2

• Such null mutants of both SIR2 and SIR3 are defective in the position-effect control of the silent loci but have no other detectable phenotype. (ox.ac.uk)
• In this study, we examined how the expression of either the lacY or the cfp gene in the native lac operon influences adjacent chromosomal segments by fluorescently labeling loci upstream and downstream of the expressed gene. (ntnu.edu.tw)

Sequence variation1

• We demonstrate in the yeast data that Lirnet can correctly suggest a specific causal sequence variation within a large, linked chromosomal region. (nih.gov)

Chromatin2

• Most conventional vectors suffer from position effects and chromatin shut down thus resulting in gene silencing over time. (biomedcentral.com)
• Chromatin position effects makes the generation of mammalian cell lines expressing the protein therapeutic a difficult, time consuming and expensive process. (biomedcentral.com)

Alleles2

• If we have a closer look (Figure 3) at the variable 'job activity', we can see that the minor alleles have a protective effect (Figure 3, middle panel) and what is surprising is that the R-squares are very high (27.64% and 27.65% respectively). (unil.ch)
• This interaction is an example of an "allelic position effect": an interaction that depends on the relative position in the genome of the two alleles, which is thought to be mediated by chromosomal pairing. (caltech.edu)

Males1

• It is clear from a scope of surveies affecting worlds and other animate beings that both hormonal and chromosomal differences between males and females affect a scope of masculine and feminine behavior. (studyhippo.com)

Understood1

• UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. (omicsdi.org)

Demonstrate2

• In this study we demonstrate that standard randomisation test procedures are of limited applicability in the presence of telomeric effects. (chalmers.se)
• This Markov model is adapted to the observed telomeric effects and then simulations are used to demonstrate properties of the suggested modified randomisation tests. (chalmers.se)

Secondary1

• Nursing assessment the secondary effect of the patients room. (berea.edu)

Explanation2

• Abnormal chromosomal segregation is a potential explanation, but abnormal telomere biology has also been postulated as a causal determinant for biological aging. (fapesp.br)
• 1 The most likely explanation is a combination of inadequate control for socioeconomic position, which the authors concede, and differences in the interval between pregnancies among teenage compared with older mothers. (bmj.com)

Adjacent1

• Variegated position effects depend on whether the gene is located in or adjacent to HETEROCHROMATIN or EUCHROMATIN . (bvsalud.org)

Differences2

• Several extensions of such standard tests are here suggested for handling clumping simultaneously with regional differences in essentiality frequencies in sub-telomeric and central gene positions. (chalmers.se)
• These encephalon differences may ensue from chromosomal differences and may besides be the consequence of hormonal differences. (studyhippo.com)

Interactions2

• We also tested if interactions of different environmental factors with SNPs have an effect on blood pressure. (unil.ch)
• CTCF protein lacking sequences critical for CP190 interactions is almost as effective as wild type in rescuing the phenotypic effects of a CTCF null allele. (sdbonline.org)

Nuclear1

• MDM2 has p53-independent transcription factor-like effects in nuclear factor-kappa beta (NFκB) activation. (mdmpathway.com)

Genome4

• However, the loss of large sections of the genome or their relocation to new positions can also have dramatic effects. (mpg.de)
• Please see [http://genome.sph.umich.edu/wiki/Rare-Metal] == What is new == * 01/04/2014 Version 5.7 is released, which added metrics for heterogeneity of genetic effects, including I2 and Q for single variant association statistics * 12/09/2014 Version 5.6 is released, which added function conditional.rareMETALS.range.group, and fixed a minor issue for estimating sample sizes. (umich.edu)
• Estimates of genetic effects and locus genetic variance == Preparing Input Files for rareMETALS == # Generate summary level statistic files: Summary statistics files can be generated by rvtests [https://github.com/zhanxw/rvtests] or rare-metal-worker [http://genome.sph.umich.edu/wiki/Rare-Metal-Worker] # Annotate your summary level statistics: In order to perform gene-level association test, summary level statistics file have to be annotated first. (umich.edu)
• Repair was less efficient at translational positions near a nucleosome dyad and at heterochromatic regions in the yeast genome. (omicsdi.org)

Neurological1

• There are limited studies regarding neurological effects in humans after inhalation exposure to pyridine. (cdc.gov)

SNPs1

• There are around 20 SNPs having almost all a positive effect on the SBP, meaning a possession of the minor allele leads to a higher blood pressure. (unil.ch)

Systemic1

• Up to date ganciclovir gel in herpetic keratitis is preferred because of its prolonged corneal reach circumstance, almost identical tonicity to tears, pH adjusted to a physiologic roam, sterilizability (autoclava- ble), want and long-lasting shelf viability, selectivity to virus-infected cells, lubricant effects seeking corneal anesthesia, aqueous humor penetration following contemporary instillation, effectiveness as acyclovir at 20 times crop concentration, and minimal/no systemic adverse effects. (daubnet.com)

Deleterious1

• Women planning to become pregnant should avoid all alcohol consumption, smoking, and use of illegal drugs (eg, cocaine) before and during the pregnancy, because these activities may have serious deleterious effects on the fetus. (medscape.com)

Protective1

• As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)

Genetic effects1

• The goal of this project is to use the Cohorte Lausannois (CoLaus) data to find environmental factors (e.g. alcohol consumption, physical activity, smoking, etc.) that modify genetic effects influencing blood pressure. (unil.ch)

Adverse effects1

• Public health officials and project managers concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAEL) have been observed. (cdc.gov)

Stable1

• Stable position effects are sequence dependent. (bvsalud.org)

Conditions2

• Charles Raymond Greene studied hormones and the effects of environmental conditions such as high-altitude on physiology in the twentieth century in the United Kingdom. (asu.edu)
• Green researched frostbite and altitude sickness during his mountaineering expeditions, helping to explain how extreme environmental conditions effect respiration. (asu.edu)

Transcription2

• CPD formation is also inhibited by DNA-bound transcription factors, in effect protecting important DNA elements from UV damage. (omicsdi.org)
• In the ventral limb bud, the transcription factor engrailed-1 (En-1) is produced. (medscape.com)

Significance1

• They should also help to determine whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)

Variants1

• However, it is unknown whether the effect of the discovered genetic variants are modified by life-style factors. (unil.ch)

Dependent1

• Furthermore, a general non-homogeneous discrete Markov approach for combining parametrically modelled position dependent probabilities of a dichotomous property with a simple single parameter clumping is suggested. (chalmers.se)

Scope1

• If this situation were not enough, one should also effects into the social, medical, philosophical and consider the unfoldings to the human dignity of the religious scope. (bvsalud.org)

Outcome1

• Of tese sperm + %success 36 7 18 35 14 23 53 54 ls mean score 30 same as for general anaesthesia in renal transplant recipients and those treated with testosterone for growth hormone secretion in for gynecomastia and significant effect on outcome. (gatech.edu)

Behavioral2

• Other effects classify decreased lung activity and behavioral difficulties (Domain Constitution Configuration, 2011). (daubnet.com)
• This showed that male sex endocrines had both physiological and behavioral effects, in rats at least. (studyhippo.com)

Patients1

• J. pies a unique position to confirm or exclude patients with ed who are affected by klinefelter unbalanced chromosomal complements in the 2. (gatech.edu)

Risk3

• Are many short-term and drugs that relieve some side effects but potentiate other risk factors as well. (lotusseedsdesign.com)
• All, they are a in a better position with acids improve endothelial function in humans at risk for atherosclerosis: A review. (lotusseedsdesign.com)
• Estimates of exposure levels posing minimal risk to humans (MRLs) have been made, where data were believed reliable, for the most sensitive noncancer effect for each exposure duration. (cdc.gov)

Parts1

• Thus, modularity is considered a key feature of biological organization that allows the modification of certain parts of organisms with minor effects on other parts, thereby contributing to evolvability [ 3 ]. (biomedcentral.com)

Biological4

• spores can be an effective biological weapon because of In this study, we used the rpoB gene as a chromosomal their high stability. (cdc.gov)
• In this essay I will be discoursing how gender can be explained from both the biological position and the societal position in order to reply the inquiry of whether sociology can in fact explain it. (studyhippo.com)
• This supports the biological position. (studyhippo.com)
• The biological position of gender is supported by those cross-cultural surveies that have found cosmopolitan characteristics of gender. (studyhippo.com)

Function1

• This regulatory potential is defined in terms of "regulatory features"-including the function of the gene and the conservation, type, and position of genetic polymorphisms-that are available for any organism. (nih.gov)

Regions1

• We have already seen a change in activity between activating the front, middle, and rear regions of the brain, as well as dosing effects. (uw.edu)

Radiation1

• Understanding the basic concepts in radiation physics, chemistry, and biology is important to the evaluation and interpretation of radiation-induced adverse health effects and to the derivation of radiation protection principles. (cdc.gov)

Health4

• the cumulative effect of social and economic exclusion on the health of mothers and their babies, whatever their age, is. (bmj.com)
• During his time at the CDC, he was the first Hispanic to attain the rank of assistant surgeon general and held a number of leadership positions focused on improving the health of mothers, children and adults in programs such as immunizations, birth defects and disabilities. (uga.edu)
• The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of pyridine and a depiction of significant exposure levels associated with various adverse health effects. (cdc.gov)
• As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

Humans1

• No useful studies were located regarding renal effects in humans after inhalation exposure to pyridine. (cdc.gov)

Investigations1

• Genetic and metabolic investigations for neurodevelopmental disorders: position statement of the Canadian College of Medical Geneticists (CCMG). (cdc.gov)

Points1

• The points in the figures showing noobserved-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)