Chromosomal Position Effects
Chromosome Mapping
Chromosomes
Role for perinuclear chromosome tethering in maintenance of genome stability. (1/41)
(+info)Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication. (2/41)
(+info)Telomeric position effect--a third silencing mechanism in eukaryotes. (3/41)
(+info)Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. (4/41)
(+info)Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure. (5/41)
(+info)The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure. (6/41)
(+info)Developmentally regulated MAPK pathways modulate heterochromatin in Saccharomyces cerevisiae. (7/41)
(+info)Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. (8/41)
(+info)
JIL-1 and Su(var)3-7 Interact Genetically and Counteract Each Others Effect on Position-Effect Variegation in Drosophila |...
Deleteriousness scores show different position effects | Open-i
BacMap
Transcription factories and chromosome structure - Oxford Neuroscience
How to use bcftools to extract chromosomal position and genotypes?
Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and...
Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood | Epigenetics &...
Position effects on eukaryotic gene expression. - Department of Physiology, Anatomy and Genetics (DPAG)
How do geneticists indicate the location of a gene?
欧洲垃圾和污水处理标准(EN)翻译目录查询
A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers - Week 3 - Dosage Compensation |...
PreCisIon: PREdiction of CIS-regulatory elements improved by genes positION. - PubMed - NCBI
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. - PubMed - NCBI
JoVE Author Search: Elgin SC
In vivo live imaging of RNA polymerase II transcription factories in primary cells. - Radcliffe Department of Medicine
Effect of Nicotinamide in Friedreich's Ataxia - Full Text View - ClinicalTrials.gov
Effect of Nicotinamide in Friedreich's Ataxia - Full Text View - ClinicalTrials.gov
Human Nucleome Reveals Amazing 4-D World | The Institute for Creation Research
Biology-Online • View topic - Traslocation
Power Calibration Area Error - Chat - ImgBurn Support Forum
David Le Monnier
ERIC - EJ1285608 - Academic Rank and Position Effect on Academic Research Output -- A Case Study of Ariel University,...
Genomic imprinting of chromatin in Drosophila melanogaster
Variegation - Wikipedia
Welcome to Xcelris Genomics
Rob Martienssen - Cold Spring Harbor Laboratory
The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression. - Inserm
Photosynthetic Redox Imbalance Governs Leaf Sectoring in the Arabidopsis thaliana Variegation Mutants immutans, spotty, var1,...
Supplementary Materials Supplemental Textiles (PDF) JCB 201601050 sm - Human Cytomegalovirus Inhibition by Cardiac Glycosides
Epigenetic inheritance of gene expression in ciliates | Ciliate-net
Studies of rearrangements involving heterochromatin in Drosophila melanogaster. I. A proof of variegated-type position effect...
A Correlation of Ring-Shaped Chromosomes with Variegation in Zea Mays (December 15, 1932)
AKC Canine Health Foundation
The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in...
China Virgin TPR/TPE/TPV Granules/Pellets TPE Raw Material Virgin TPE Granules - China Tr Raw Material/TPR Granule for Shoes...
Artificial Ficus Tree With Variegation Leaves 2m - JNR-Studio
Cp190 - Centrosome-associated zinc finger protein CP190 - Drosophila melanogaster (Fruit fly) - Cp190 gene & protein
Silencing DNAmet-imprin 2012
Localization of Sir2p: the nucleolus as a compartment for silent information regulators | The EMBO Journal
Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional...
Gene repositioning within the cell nucleus is not random and is determined by its genomic neighborhood. - TUbiblio
Kenyas Ballot Scars - allAfrica.com
Matthew Zook
TPE 2003 - Anti-Fogging
TPE Male Sex Doll Blond Jimmy 5ft 2 (160 cm) | Naughty Harbor
WERAM - Writers, Erasers & Readers of Histone Acetylation and Methylation Database
Suv420h1 (untagged) - Mouse suppressor of variegation 4-20 homolog 1 (Drosophila) (Suv420h1), transcript variant 5, (10ug) -...
Gabrîyêl - Medium
Proteins: Recombinant, Native & Peptides | Cell Sciences
Insulated neighborhood
Kellum, R; Schedl, P (8 March 1991). "A position-effect assay for boundaries of higher order chromosomal domains". Cell. 64 (5 ... element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect ... Chromosomal alterations such as translocations, deletions and tandem duplications intersecting with insulated neighborhood ... Geyer, PK; Corces, VG (October 1992). "DNA position-specific repression of transcription by a Drosophila zinc finger protein". ...
Abby Dernburg
The study demonstrated the effect of chromosomal positioning on gene expression. Dernburg also studied the role heterochromatin ... Specifically, she used FISH to monitor the chromosomal position of regions of heterochromatin-a tightly packed region of DNA ...
Biodiversity
Wahl, GM; Robert de Saint Vincent B; Derose, ML (1984). "Effect of chromosomal position on amplification of transfected genes ... Effect of diversity on flood regulation (In a survey of the literature, the investigators could not find any studies) Effect of ... Allen A. P.; Gillooly J. F.; Savage V. M.; Brown J. H. (2006). "Kinetic effects of temperature on rates of genetic divergence ... The overuse of these finite resources by at least 56% has had a devastating effect on biodiversity, which is crucial to ...
Position-effect variegation
Six second chromosomal mus mutations were isolated with wm4. A copy of wild-type white gene was placed adjacent to ... PEV is a position effect because the change in position of a gene from its original position to somewhere near a ... "position-effect". Tartof, Kenneth D.; Hobbs, Cheryl; Jones, Marilyn (1984-07-01). "A structural basis for variegating position ... Position-effect variegation (PEV) is a variegation caused by the silencing of a gene in some cells through its abnormal ...
Limb bud
The Hox genes are linked in four chromosomal clusters: Hoxa, Hoxb, Hoxc, and Hoxd. Their physical position on the chromosome ... This means that although Shh signaling is required, its effects change over time as the mesoderm is primed to respond to it ... Within the limb bud, expression of specific Hox genes varies as a function of the position along the anterior-posterior axis. ... Though limbs emerge at different locations in different species, their positions always correlate with the level of Hox gene ...
RASGRP1
Bottorff D, Ebinu J, Stone JC (May 1999). "RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions". ... The drug was able to reverse certain effects of the mutation RASGRP1. GRCh38: Ensembl release 89: ENSG00000172575 - Ensembl, ...
BESS domain
Reuter G, Giarre M, Farah J, Gausz J, Spierer A, Spierer P (March 1990). "Dependence of position-effect variegation in ... Zhao K, Hart CM, Laemmli UK (June 1995). "Visualization of chromosomal domains with boundary element-associated factor BEAF-32 ... the phantom of the modifier of position-effect variegation Su(var)3-7". Int. J. Dev. Biol. 46 (1): 167-71. PMID 11902679. This ...
Hally Jolivette Sax
She often collaborated with Karl on chromosomal studies, especially those related to the effects of radiation and chemicals on ... She worked for a year for the U.S. Department of Agriculture (1914-15) before taking up a position as an instructor of botany ... Radiomimetic effects on Veratrum (1968, with Karl Sax and Wayne Binns) Effects of sonic energy on chromosomes (1970, with Karl ... Radiomimetic effects (1965, with Karl Sax and H.J. Teas) Radiomimetic beverages, drugs, and mutagens (1966, with Karl Sax) ...
Position effect
These phenotypes are often due to a chromosomal translocation such that the color gene is now close to a region of ... Position effect is the effect on the expression of a gene when its location in a chromosome is changed, often by translocation ... Position effects on gene expression in two different eucaryotic organisms". Molecular biology of the cell (4th ed.). New York: ... Position effect is also used to describe the variation of expression exhibited by identical transgenes that insert into ...
Sarah Elgin
Wallrath, LL; Elgin, SCR (1995-05-15). "Position effect variegation in Drosophila is associated with an altered chromatin ... Silver, L M; Elgin, S C (February 1976). "A method for determination of the in situ distribution of chromosomal proteins". Proc ... this phenomenon is known as Position-effect variegation. Nuclease digestion assays have confirmed that the eye phenotypes are ... She continued to isolate and characterize nonhistone chromosomal proteins but started studying Drosophila. After her postdoc, ...
Glossary of genetics
position effect Any effect on the expression or functionality of a gene or sequence that is a consequence of its location or ... chromosomal crossover chromosomal duplication The duplication of an entire chromosome, as opposed to a segment of a chromosome ... Position effects are a major focus of research in the field of epigenetic inheritance. positional cloning A strategy for ... position effects, or infection by pathogens. variome vector Any DNA molecule used as a vehicle to artificially transport ...
Lawrence B. Salkoff
2. Gain-of-function mutant (Sh5) (which changed the inactivation kinetics of the current, 3. Position effect conferred by the ... Salkoff found that the W32 chromosomal broke within or close to the Shaker gene. This study showing the location of the Shaker ... and position effect mutations where a breakpoint near the gene reduces expression of a normal gene product. All three classes ... These studies validated the Shaker gene as the structural locus of a potassium channel and guided a chromosomal "walking" ...
Intragenomic conflict
Green-beard effect Gardner, Andy; Úbeda, Francisco (6 November 2017). "The meaning of intragenomic conflict". Nature Ecology & ... Transposons are autonomous replicating genes that encode the ability to move to new positions in the genome and therefore ... The best-studied examples include the neocentromeres (knobs) of maize, as well as several chromosomal rearrangements in mammals ... R. W. Beeman; K. S. Friesen; R. E. Denell (1992). "Maternal-effect selfish genes in flour beetles" (PDF). Science. 256 (5053): ...
RpoS
The position of the first site upstream of the major rpoS promoter corresponds to a "classical activator" similarly found in ... The regulatory effect in this case is RpoS down regulation of SCOT expression in response to oxidative stress in B. ... Transcription of rpoS in E. coli is mainly regulated by the chromosomal rpoSp promoter. rpoSp promotes transcription of rpoS ... the lac promoter thereby suggesting that its effects on transcription are activating (Lange and Hengge-Aronis, 1994); in ...
Apical ectodermal ridge
The Hox genes are "physically linked in four chromosomal clusters (Hoxa, Hoxb, Hoxc, Hoxd), and their physical position on the ... This means that although Shh signaling is required, its effects change over time as the mesoderm is primed to respond to it ... The position of the limb bud, and hence the AER, is specified by the expression boundaries of Hox genes in the embryonic trunk ... At these positions, the induction of cell outgrowth is thought to be mediated by a positive feedback loop of fibroblast growth ...
Microevolution
... they occupy consistent chromosomal positions, they may be polygenic or based on few genes, they may display additive, dominant ... The effect of genetic drift is larger in small populations, and smaller in large populations. Vigorous debates wage among ... Due to the damaging effects that mutations can have on cells, organisms have evolved mechanisms such as DNA repair to remove ... In organisms that use chromosomal crossover to exchange DNA and recombine genes, errors in alignment during meiosis can also ...
Marginal zone B-cell lymphoma
... chromosomal translocation between the short (i.e. "p") arm of chromosome 2 at position 24 and the long (i.e. "q") arm of ... trisomy of chromosomes 7 and 12 and deletion of the long arm of chromosome 6 which have as yet unknown functional effects; and ... arm of chromosome 11 at position 21 with the q arm of chromosome 18 at position 21 (notated as a t(11;18)(q21;q21) ... Chromosomal abnormalities such as: 1) trisomy of chromosome 3 (24% of cases) which causes the overexpression of FOXP1, NFKBIZ, ...
Z-DNA
The toxic effect of ethidium bromide (EtBr) on trypanosomas is caused by shift of their kinetoplastid DNA to Z-form. The shift ... Because of this property, Z-DNA is hypothesized to code for the boundary in nucleosome positioning. Since the placement of ... In mammalian cells, the presence of such sequences was found to produce large genomic fragment deletions due to chromosomal ... had little to no effect on pathogenicity of the virus in mice. In Contrast, Kim, Y. et al. also found that deleting all 83 ...
Subtelomere
This deletion is thought to cause disease owing to a position effect that influences the transcription of nearby genes, rather ... The duplication, recombination, and deletion of subtelomeres allow for the creation of new genes and new chromosomal properties ... Sgo2 has also repressive effects for timing of subtelomeres replication by suppressing Sld3, a replication factor, at the start ... However, the use of inter-chromosomal circularization engenders chromosome instability by creating two centromeres in a single ...
Matilda effect
Stevens greatly influenced the scientific community's transition to this new line of inquiry: Chromosomal sex determination. ... despite having equal qualification as him for a professorial position. Rosalind Franklin (1920-1958) - now recognized as an ... The Matilda effect was compared to the Matthew effect, whereby an eminent scientist often gets more credit than a comparatively ... "Matilda effect" was coined in 1993 by science historian Margaret W. Rossiter. Rossiter provides several examples of this effect ...
RIOK1
... and a chromosomal location of human orthodox 6p24.3. (6:7,389,496-7,418,037) Effects on modified protein - protein degradation ... in positions 329 and 349 and 2 active sites in positions 324 (which is a proton acceptor) and 341 (4-aspartylphosphate ... Effects on biological progress - cell growth, inhibited, triggered by K411-m1. The effect of the experimental mutation of one ... When amino acid residues are altered, we report the change, the name of the mutant (if known), and the effects of the mutation ...
Netrin receptor DCC
DCC would fall into the chromosomal instability category. The chromosomal region of 18q has shown consistent LOH for nearly ... In a cancer state, the absence of DCC prevents the gradient from having an effect on the cell, making it more likely to ... into the mechanisms of DCC signaling and in-vitro studies of DCC modifications have solidified DCC's tumour suppressor position ... As the 18q chromosomal deletions were never resolved to be related solely to another gene, DCC was rapidly reaccepted as a ...
Microbeam
Experiments performed at microbeam facilities have since shown the existence of a bystander effect. A bystander effect is any ... Cell positioning must have high spatial resolution and reproducibility in order that the ion beam hit the target with a high ... Many biological endpoints have been studied including oncogenic transformation, apoptosis, mutations, and chromosomal ... it is necessary to be able to extrapolate from the effects of multiple traversals to the effects of single traversals of a ...
SALL1
... detection of a SALL1 mutation hot spot and evidence for a position effect in one patient". Human Mutation. 14 (5): 377-86. doi: ... Buck A, Archangelo L, Dixkens C, Kohlhase J (2000). "Molecular cloning, chromosomal localization, and expression of the murine ... "Detection of heterozygous SALL1 deletions by quantitative real time PCR proves the contribution of a SALL1 dosage effect in the ...
Recombinant inbred strain
The precision with which these recombinations are mapped is a function of the number and position of the genotypes used to type ... the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci). ... the greater the power and resolution with which phenotypes can be mapped to chromosomal locations. The first set of eight ... For an RI strain to be useful for mapping purposes, the approximate position of recombinations along each chromosome need to be ...
MYH9
March 2008). "Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related ... Ford HL, Silver DL, Kachar B, Sellers JR, Zain SB (December 1997). "Effect of Mts1 on the structure and activity of nonmuscle ... chromosomal localization, and upregulation during myeloid differentiation". Blood. 78 (7): 1826-33. doi:10.1182/blood.V78.7. ... Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were ...
Thomas Hunt Morgan
Morgan worked at Columbia University for 24 years, from 1904 until 1928 when he left for a position at the California Institute ... The relevance of mutations for evolution is that only characters that are inherited can have an effect in evolution. Since ... He was initially skeptical of Mendel's laws of heredity (as well as the related chromosomal theory of sex determination), which ... In Evolution and Adaptation (1903), he argued the anti-Darwinist position that selection could never produce wholly new species ...
Chromatin bridge
This effect is created when sticky ends of chromosomes remain connected to one another, even after mitosis. A chromatin bridge ... This instability, defined as frequent changes in chromosomal structure and number, may be the basis of the development of ... Because microtubules maintain the positions of the chromosomes during mitosis, they appear to be densely pinched between the ... As a result, several forms of chromosomal aberrations occur, including, but not limited to, binucleated cells, multipolar ...
INPP1
This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate ... Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were ... York JD, Veile RA, Donis-Keller H, Majerus PW (Jul 1993). "Cloning, heterologous expression, and chromosomal localization of ...
Lavender (chicken plumage)
The dilution effect is essentially the result of a mixture of pigmented and unpigmented regions within the feather barbs. The ... its position has not yet mapped., Until now, all the reported causal mutations in MLPH (melanophilin) of humans, mice and other ... the lavender phenotype is associated with a non-lethal complex mutation involving three consecutive overlapping chromosomal ... The deletion of PRLH has no effect on the level of circulating prolactin. Lavender birds have lighter body weight, lower body ...
Better recognition of chromosomal diseases | Max-Planck-Gesellschaft
However, the loss of large sections of the genome or their relocation to new positions can also have dramatic effects. Often, ... Chromosomal breaks often lead to disruption of chromatin domains, sometimes with severe effects. "Imagine these domains as ... In the clinical samples examined, the team was able to not only confirm the existing findings and specify the effect of ... Chromosomal rearrangements may alter these interaction patterns and can thus be seen in the analysis. ...
Diversity of genetic events associated with MLH1 promoter methylation in Lynch syndrome families with heritable constitutional...
Some of these epimutations, termed secondary, correspond to the epigenetic effects of cis-acting genetic defects transmitted to ... Alpha-thalassemia resulting from a negative chromosomal position effect. Blood 2000;96:800-807. ... Analysis of RNA extracted from patients III-1, IV-2, and P4 lymphoblastoid cell lines showed no effect of the variant c.116+ ... Some of these epimutations, termed secondary, correspond to the epigenetic effects of cis-acting genetic defects transmitted to ...
Testing of Chromosomal Clumping of Gene Properties
This Markov model is adapted to the observed telomeric effects and then simulations are used to demonstrate properties of the ... Furthermore, a general non-homogeneous discrete Markov approach for combining parametrically modelled position dependent ... One such regional dependency is the telomeric effect, observed in several studies of Saccharomyces cerevisiae, under which e. g ... essential genes are less likely to reside near the chromosomal ends. In this study we demonstrate that standard randomisation ...
Can environmental factors modify the effect of genes influencing blood pressure? - CBG
In the upper panel, the -log10(p-values) of each SNP are plotted against their chromosomal position. The pink points above the ... Effects of the genetic variants (snps) on the phenotype. *Effect of the interaction of the environmental factors and the snps ... Effects of the environmental factors on the phenotype (systolic blood pressure for linear regression and a binary variable for ... There are around 20 SNPs having almost all a positive effect on the SBP, meaning a possession of the minor allele leads to a ...
Learning a prior on regulatory potential from eQTL data
... and position of genetic polymorphisms-that are available for any organism. The extent to which the different features influence ... estimating how likely it is to have a significant effect on gene expression. This regulatory potential is defined in terms of " ... linked chromosomal region. In one example, Lirnet uncovered a novel, experimentally validated connection between Puf3-a ... where traits are often linked to large chromosomal regions containing many genes. Here, we present a novel method, Lirnet, that ...
Cells | Free Full-Text | Three-Dimensional Genome Organization in Breast and Gynecological Cancers: How Chromatin Folding...
Through chromosomal looping, cis-regulatory elements interact which each other to control gene expression by bringing distant ... These proteins also contribute to the insulator function constraining the heterochromatin-associated position-effect ... Gruber, S.; Haering, C.; Nasmyth, K. Chromosomal Cohesin Forms a Ring. Cell 2003, 112, 765-777. [Google Scholar] [CrossRef][ ... Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc. Natl. ...
EN (en)
MH DELETED MN ADDED MN
Chromosomal Position Effects G5.355.315.203.124 G5.308.203.124 Chromosome Breakage G5.355.180.210.170 G5.200.210.170 Chromosome ... Graft vs Leukemia Effect G12.425.901.402.320.320 G12.875.402.320.320 Graft vs Tumor Effect G12.425.901.402.320 G12.875.402.320 ... Bystander Effect G4.299.122.155 G4.85.155 CA-125 Antigen D12.776.395.560.631.50 Caffeine D3.438.759.758.824.175 D3.633.100.759. ... Greenhouse Effect G16.500.240.135.827 G16.500.175.827 Griseofulvin D3.438.127.275 D3.633.100.127.275 Group Homes J3.775.375 ...
Prognostic Significance of Molecular Markers and Extent of Resection in Primary Glioblastoma Patients | Clinical Cancer...
The MGMT gene maps to chromosomal band 10q26 and encodes a DNA repair protein that removes alkyl groups from the O6-position of ... Thus, high levels of MGMT may counteract the therapeutic effect of alkylating agents such as temozolomide and lead to treatment ... The amplification level of each gene was normalized to the dosage of the genomic marker D2S1743 (WI3306.1) at chromosomal band ... Furthermore, our findings suggest an additive effect of both parameters, with those patients having MGMT-methylated and near- ...
Part 1 - The tools of control
Position effects of this kind can influence the concentration of a gene product in the cell, or a genes activation timeframe. ... but that its location in its chromosomal, cellular, physiological and evolutionary context also plays a significant role. ... Allergenic effects could he carried by the transgene or be stimulated by imbalances in the chemistry of the host plant or ... Nevertheless, this position does not exclude the possibility that functions could be corrected by trial and error in certain ...
Chromosome 11: MedlinePlus Genetics
Other chromosomal conditions. Other changes in the number or structure of chromosome 11 can have a variety of effects, ... Potocki-Shaffer syndrome is caused by the deletion of a segment of the short (p) arm of chromosome 11 at a position described ... Health Conditions Related to Chromosomal Changes. The following chromosomal conditions are associated with changes in the ... These chromosomal changes are somatic, which means they are acquired during a persons lifetime and are present only in certain ...
GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content...
Flanking oligonucleotide sequences, chromosomal positions (best BLAST hit) and genotype calls for the 24,338unique polymorphic ... v is a vector of fixed population effects, u is a vector of random genetic background effects, and e is the vector of residuals ... The variances of the random effects u and e are assumed to be normally distributed with u ~ N (0, \( {\mathrm{G}\upsigma}_{\ ... Yao, M., Guan, M., Zhang, Z. et al. GWAS and co-expression network combination uncovers multigenes with close linkage effects ...
SMART: PostSET domain annotation
transposition】什么意思 英语transposition的翻译 音标 读音 用法 例句 在线翻译
genetics) a kind of mutation in which a chromosomal segment is transfered to a new position on the same or another chromosome ... electricity) a rearrangement of the relative positions of power lines in order to minimize the effects of mutual capacitance ... any abnormal position of the organs of the body 同义词: heterotaxy ...
B-cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse...
P3 at the 3-position of the inositol ring converting PI(3,4,5)P3 back to PI(4,5)P2.13,14 Loss of PTEN results in accumulation ... as a result of chromosomal translocations and inversions at 14q31.2.16 Although such a defect is not found in CLL, TCL1 is ... 25 In order to investigate the effects of BCR deficiency on BCR signaling and the PI3K pathway in CLL cells, we assessed the ... via phosphorylating the 3-position of the inositol ring of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2).13 On the contrary ...
Molecular genetics of the Drosophila eyes absent gene - CaltechTHESIS
... which is an allelic position effect that is sensitive to certain kinds of chromosomal rearrangements. A current model for the ... This interaction is an example of an "allelic position effect": an interaction that depends on the relative position in the ... genome of the two alleles, which is thought to be mediated by chromosomal pairing. The interaction at eya is essentially ...
Mammalian Expression
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... maximizing its potential to be transcribed into protein irrespective of the position of the transgene in the chromosome.. UCOE ... technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure ... stable and high-level gene expression irrespective of the chromosomal integration site yielding 20-fold higher protein ... UCOE technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the ...
Biology (Duluth) - Research output
- [email protected]
JIL-1 and Su(var)3-7 interact genetically and counteract each others effect on position-effect variegation in drosophila. Deng ... Space-dependent effects of floral abundance on flower visitors. Ikemoto, M., Ohgushi, T. & Craig, T. P., Jun 2011, In: Journal ... Effects of simulated moose Alces alces browsing on the morphology of rowan Sorbus aucuparia. Jager, N. R. D. & Pastor, J., Sep ... Water chemistry and its effects on the physiology and survival of Atlantic salmon Salmo salar smolts. Liebich, T., McCormick, S ...
Frontiers | A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort
... measure and the horizontal axis is the chromosomal position with corresponding genes illustrated below. The blue dot represents ... Therefore, the effect of rs2253206 on cognitive function observed in our cohort may occur via altered expression levels of ... We have previously reported a significant effect of the APOE 𝜀4 polymorphism in PM using the CAPM test in a smaller subset of ... Raskin, S. A., Buckheit, C. A., and Waxman, A. (2012). Effect of type of cue, type of response, time delay and two different ...
DeCS
Chromosomal Position Effect Position Effect, Chromosomal Position Effects, Chromosomal Position Effect Variegation - Narrower ... Chromosomal Position Effect. Position Effect Variegation. Position Effect, Chromosomal. Position Effects, Chromosomal. ... Chromosomal Position Effects - Preferred Concept UI. M0512484. Scope note. The effects on gene expression that depend on the ... Stable position effects are sequence dependent. Variegated position effects depend on whether the gene is located in or ...
Publikationen
Computational Prediction of Position Effects of Apparently Balanced Human Chromosomal Rearrangements. 2017. The American ... Fractional quantum Hall effect in the interacting Hofstadter model via tensor networks. 2017. Physical Review B. Vol. 96(19), ... The effect of rheological approximations in 3-D numerical simulations of subduction and collision. 2018. Tectonophysics. Vol. ... Sensitivity of aerosol radiative effects to different mixing assumptions in the AEROPT 1.0 submodel of the EMAC atmospheric- ...
Biologia i Ecologia Bentòniques - Genètica: Francesc Mestres
Heterotic effect of chromosomal arrangements revealed by the persistence of lethal genes". Proc. Natl. Acad. Sci. U.S.A. 98: ... a computer program to reconstruct the position of chromosomes on the metaphase plate". Hereditas 132: 157-159. ... MESTRES, F., FIGUERAS, M. T. and SERRA, L. (2002). "A cytological study of the O5 chromosomal inversion of D. subobscura ( ... ESTEVE, C., LAGARES, C. and MESTRES, F. (2020). First detection of chromosomal inversions in a natural population of the ...
Characterization of two genes required for the position-effect control of yeast mating-type genes. - Oxford Neuroscience
... coding sequences were identified by constructing gene disruptions and using these mutations to replace the normal chromosomal ... Such null mutants of both SIR2 and SIR3 are defective in the position-effect control of the silent loci but have no other ... Such null mutants of both SIR2 and SIR3 are defective in the position-effect control of the silent loci but have no other ... Characterization of two genes required for the position-effect control of yeast mating-type genes. ...
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
... between chromosome X and 1 in the patient suggest either the disruption of a critical gene expression due to position effect or ... Chromosomal analysis of the proband revealed a de novo translocation of 46, X, t(X; 1) (q21; p32) chromosomal constitution. ... Chromosomal analysis revealed 46,XX karyotype. Hormonal investigations indicated low levels of cortisol and elevated levels of ... METHODS: Chromosomal analysis was performed by harvesting lymphocytes from peripheral blood sample. Hormonal analysis was ...
Daubnet Community • Ines, Esiel, Nemrok and Marcus Belgium
Side positioning is generally speaking preferred, as the toddler may get tribulation handling vocalized secretions if the level ... Only one chromosomal numerical abnormalities are compatible with full-term maturity and most denouement in mechanical abortion ... Other effects classify decreased lung activity and behavioral difficulties (Domain Constitution Configuration, 2011). Bellow, ... Jeopardy for caregiver position push В· Concerned portion counterpart After completing an assessment on Ethan, you note the ...
Online Geographies Of Forced Eviction Dispossession Violence Resistance 2017
To be the present environments for promoters in the first hazard, we are the position is for the line of case level FIG.; ... Meyer, chromosomal online geographies of forced eviction coding and information assays, 2000 Plant Mol. online geographies of ... An online protein is even as of effect, for matrix example of error or orientation structure. null using is until commercially ... If you are at an online geographies of forced or chromosomal translation, you can be the chemistry component to require a model ...
GenesChromosomeChromosomesAbnormalitiesGene expressionRearrangementRearrangementsProteinsDrosophilaMutationEpigeneticLociSequence variationChromatinAllelesMalesUnderstoodDemonstrateSecondaryExplanationAdjacentDifferencesInteractionsNuclearGenomeNeurologicalSNPsSystemicDeleteriousProtectiveGenetic effectsAdverse effectsStableConditionsTranscriptionSignificanceVariantsDependentScopeOutcomeBehavioralPatientsRiskPartsBiologicalFunctionRegionsRadiationHealthHumansInvestigationsPoints
Genes10
- Even if all genes remain intact after a chromosomal break, serious problems may occur. (mpg.de)
- The team examined clinical samples from blood, skin and amniotic fluid of nine patients with chromosomal breaks but without damage to known genes. (mpg.de)
- One such regional dependency is the telomeric effect, observed in several studies of Saccharomyces cerevisiae, under which e. g. essential genes are less likely to reside near the chromosomal ends. (chalmers.se)
- Can environmental factors modify the effect of genes influencing blood pressure? (unil.ch)
- The problem is particularly challenging in populations with significant linkage disequilibrium, where traits are often linked to large chromosomal regions containing many genes. (nih.gov)
- UCOE® technology expression elements are small DNA elements (isolated from around house-keeping genes, which need to be active most of the time) which create a transcriptionally active open chromatin environment around an integrated transgene, maximizing its potential to be transcribed into protein irrespective of the position of the transgene in the chromosome. (emdmillipore.com)
- The effects on gene expression that depend on the location of a gene with respect to its neighboring genes and region of chromosome. (bvsalud.org)
- Characterization of two genes required for the position-effect control of yeast mating-type genes. (ox.ac.uk)
- Chromosomal distribution of genes, are required for statistical testing of this hypothesis point, ligament, peritendon region, perineural region and the epidural space. (lotusseedsdesign.com)
- Telomeres are also implicated in transcriptional reversible gene silencing of nearby genes, leading to telomere position effect (TPE), which can promote modifications in cell biology. (fapesp.br)
Chromosome6
- The researchers applied a method called 'Hi-C' (High-throughput Chromosome Conformation Capture) to samples from patients with developmental disorders suspected to be caused by chromosomal rearrangements. (mpg.de)
- The following chromosomal conditions are associated with changes in the structure or number of copies of chromosome 11. (medlineplus.gov)
- Complex chromosome rearrangements (CCRs) are structural chromosomal rearrangements involving at least three chromosomes and more than two breakpoints. (e-kjgm.org)
- Based on the motion behaviors of the chromosome locus pair, the relaxation and the reorganization of the local chromosomal segments have been qualitatively and quantitatively resolved. (ntnu.edu.tw)
- The regional spatial shift to the cell membrane and the more significant changes of the correlated motion suggest the existence of the membrane-involved influence on the local chromosomal segments in the membrane protein expression, and it can be a key factor to segregate the whole bacterial chromosome. (ntnu.edu.tw)
- This chromosomal alteration only affects female individuals, who have monosomy of the X chromosome. (bvsalud.org)
Chromosomes4
- The classical analysis of chromosomal defects is done by a karyogram, which is a microscopic view of stained chromosomes. (mpg.de)
- Interpretation of statistical tests based on these assumptions may be misleading if dependencies exist that are unequal between chromosomes or in different chromosomal parts. (chalmers.se)
- The parent carries a chromosomal rearrangement between chromosomes 11 and 22 called a balanced translocation. (medlineplus.gov)
- With this approach, we demonstrate that transposons engage in long-range intra-chromosomal interactions guided by the separation of chromosomes into A and B compartments as well as topologically associated domains (TADs). (springer.com)
Abnormalities2
Gene expression8
- Here, we present a novel method, Lirnet, that automatically learns a regulatory potential for each sequence polymorphism, estimating how likely it is to have a significant effect on gene expression. (nih.gov)
- The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl.de)
- Ubiquitous Chromatin Opening Element (UCOE®) technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. (emdmillipore.com)
- UCOE® technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site. (emdmillipore.com)
- UCOE technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. (emdmillipore.com)
- UCOE technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site yielding 20-fold higher protein expression levels than conventional vectors. (emdmillipore.com)
- Cell to cell variation in gene expression caused by chromosomal position effects. (bvsalud.org)
- To reveal the details of the effect induced by the gene expression, the positions and the motions of the local chromosomal segments around the lactose operon have been investigated. (ntnu.edu.tw)
Rearrangement2
- About 1 percent of all people with Beckwith-Wiedemann syndrome have a chromosomal abnormality such as a rearrangement (translocation) involving 11p15.5 or abnormal copying (duplication) or deletion of genetic material in this region. (medlineplus.gov)
- The reason for the retinitis pigmentosa phenotype in patient BB remains unclear, but the most likely explanations include a long-range chromosomal position effect, a small secondary rearrangement, and the presence of a coincident autosomal form of retinitis pigmentosa. (abertay.ac.uk)
Rearrangements4
- Chromosomal rearrangements may alter these interaction patterns and can thus be seen in the analysis. (mpg.de)
- The interaction at eya is essentially identical to a phenomenon known as transvection, which is an allelic position effect that is sensitive to certain kinds of chromosomal rearrangements. (caltech.edu)
- Because chromosomal rearrangements can affect the genotype-phenotype map of individuals and thus modify the patterns of covariation between traits, we also evaluate the effect of Robertsonian translocations on the modularity pattern of the sperm head. (biomedcentral.com)
- The reduction in percentages of shape covariation between pairs of modules in Rb sperms suggests that chromosomal rearrangements could induce changes in the genotype-phenotype map. (biomedcentral.com)
Proteins1
- His research focused on the molecular biology of chromosomal proteins. (uga.edu)
Drosophila4
- Based on sequence information from the SET domain, we have isolated human (SUV39H1) and mouse (Suv39h1) homologues of the dominant Drosophila modifier of position-effect-variegation (PEV) Su(var)3-9. (embl.de)
- First detection of chromosomal inversions in a natural population of the invasive pest species Drosophila suzukii . (ub.edu)
- Chromosomal Thermal Index: a comprehensive way to integrate the thermal adaptation of Drosophila subobscura whole karyotype" Genome 61: 73-78. (ub.edu)
- Medium-term changes in Drosophila subobscura chromosomal inversion polymorphism: a possible relation with global warming? (ub.edu)
Mutation1
- The mutation does, however, affect CP190 recruitment to specific insulator elements and has a modest effect on CTCF chromatin association. (sdbonline.org)
Epigenetic2
- Some of these epimutations, termed secondary, correspond to the epigenetic effects of cis -acting genetic defects transmitted to the offspring following a Mendelian inheritance pattern. (nature.com)
- 2 primary epimutations corresponding to pure epigenetic events, labile in the germ line and thus reversible between generations (although non-Mendelian inheritance might be occasionally observed 11 ), and secondary epimutations corresponding to the secondary epigenetic effects of cis -acting genetic alterations transmitted following a Mendelian inheritance pattern, with re-establishment of the epigenetic change in the offspring. (nature.com)
Loci2
- Such null mutants of both SIR2 and SIR3 are defective in the position-effect control of the silent loci but have no other detectable phenotype. (ox.ac.uk)
- In this study, we examined how the expression of either the lacY or the cfp gene in the native lac operon influences adjacent chromosomal segments by fluorescently labeling loci upstream and downstream of the expressed gene. (ntnu.edu.tw)
Sequence variation1
- We demonstrate in the yeast data that Lirnet can correctly suggest a specific causal sequence variation within a large, linked chromosomal region. (nih.gov)
Chromatin2
- Most conventional vectors suffer from position effects and chromatin shut down thus resulting in gene silencing over time. (biomedcentral.com)
- Chromatin position effects makes the generation of mammalian cell lines expressing the protein therapeutic a difficult, time consuming and expensive process. (biomedcentral.com)
Alleles2
- If we have a closer look (Figure 3) at the variable 'job activity', we can see that the minor alleles have a protective effect (Figure 3, middle panel) and what is surprising is that the R-squares are very high (27.64% and 27.65% respectively). (unil.ch)
- This interaction is an example of an "allelic position effect": an interaction that depends on the relative position in the genome of the two alleles, which is thought to be mediated by chromosomal pairing. (caltech.edu)
Males1
- It is clear from a scope of surveies affecting worlds and other animate beings that both hormonal and chromosomal differences between males and females affect a scope of masculine and feminine behavior. (studyhippo.com)
Understood1
- UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. (omicsdi.org)
Demonstrate2
- In this study we demonstrate that standard randomisation test procedures are of limited applicability in the presence of telomeric effects. (chalmers.se)
- This Markov model is adapted to the observed telomeric effects and then simulations are used to demonstrate properties of the suggested modified randomisation tests. (chalmers.se)
Secondary1
- Nursing assessment the secondary effect of the patients room. (berea.edu)
Explanation2
- Abnormal chromosomal segregation is a potential explanation, but abnormal telomere biology has also been postulated as a causal determinant for biological aging. (fapesp.br)
- 1 The most likely explanation is a combination of inadequate control for socioeconomic position, which the authors concede, and differences in the interval between pregnancies among teenage compared with older mothers. (bmj.com)
Adjacent1
- Variegated position effects depend on whether the gene is located in or adjacent to HETEROCHROMATIN or EUCHROMATIN . (bvsalud.org)
Differences2
- Several extensions of such standard tests are here suggested for handling clumping simultaneously with regional differences in essentiality frequencies in sub-telomeric and central gene positions. (chalmers.se)
- These encephalon differences may ensue from chromosomal differences and may besides be the consequence of hormonal differences. (studyhippo.com)
Interactions2
- We also tested if interactions of different environmental factors with SNPs have an effect on blood pressure. (unil.ch)
- CTCF protein lacking sequences critical for CP190 interactions is almost as effective as wild type in rescuing the phenotypic effects of a CTCF null allele. (sdbonline.org)
Nuclear1
- MDM2 has p53-independent transcription factor-like effects in nuclear factor-kappa beta (NFκB) activation. (mdmpathway.com)
Genome4
- However, the loss of large sections of the genome or their relocation to new positions can also have dramatic effects. (mpg.de)
- Please see [http://genome.sph.umich.edu/wiki/Rare-Metal] == What is new == * 01/04/2014 Version 5.7 is released, which added metrics for heterogeneity of genetic effects, including I2 and Q for single variant association statistics * 12/09/2014 Version 5.6 is released, which added function conditional.rareMETALS.range.group, and fixed a minor issue for estimating sample sizes. (umich.edu)
- Estimates of genetic effects and locus genetic variance == Preparing Input Files for rareMETALS == # Generate summary level statistic files: Summary statistics files can be generated by rvtests [https://github.com/zhanxw/rvtests] or rare-metal-worker [http://genome.sph.umich.edu/wiki/Rare-Metal-Worker] # Annotate your summary level statistics: In order to perform gene-level association test, summary level statistics file have to be annotated first. (umich.edu)
- Repair was less efficient at translational positions near a nucleosome dyad and at heterochromatic regions in the yeast genome. (omicsdi.org)
Neurological1
- There are limited studies regarding neurological effects in humans after inhalation exposure to pyridine. (cdc.gov)
SNPs1
- There are around 20 SNPs having almost all a positive effect on the SBP, meaning a possession of the minor allele leads to a higher blood pressure. (unil.ch)
Systemic1
- Up to date ganciclovir gel in herpetic keratitis is preferred because of its prolonged corneal reach circumstance, almost identical tonicity to tears, pH adjusted to a physiologic roam, sterilizability (autoclava- ble), want and long-lasting shelf viability, selectivity to virus-infected cells, lubricant effects seeking corneal anesthesia, aqueous humor penetration following contemporary instillation, effectiveness as acyclovir at 20 times crop concentration, and minimal/no systemic adverse effects. (daubnet.com)
Deleterious1
- Women planning to become pregnant should avoid all alcohol consumption, smoking, and use of illegal drugs (eg, cocaine) before and during the pregnancy, because these activities may have serious deleterious effects on the fetus. (medscape.com)
Protective1
- As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)
Genetic effects1
- The goal of this project is to use the Cohorte Lausannois (CoLaus) data to find environmental factors (e.g. alcohol consumption, physical activity, smoking, etc.) that modify genetic effects influencing blood pressure. (unil.ch)
Adverse effects1
- Public health officials and project managers concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAEL) have been observed. (cdc.gov)
Stable1
- Stable position effects are sequence dependent. (bvsalud.org)
Conditions2
- Charles Raymond Greene studied hormones and the effects of environmental conditions such as high-altitude on physiology in the twentieth century in the United Kingdom. (asu.edu)
- Green researched frostbite and altitude sickness during his mountaineering expeditions, helping to explain how extreme environmental conditions effect respiration. (asu.edu)
Transcription2
- CPD formation is also inhibited by DNA-bound transcription factors, in effect protecting important DNA elements from UV damage. (omicsdi.org)
- In the ventral limb bud, the transcription factor engrailed-1 (En-1) is produced. (medscape.com)
Significance1
- They should also help to determine whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)
Variants1
- However, it is unknown whether the effect of the discovered genetic variants are modified by life-style factors. (unil.ch)
Dependent1
- Furthermore, a general non-homogeneous discrete Markov approach for combining parametrically modelled position dependent probabilities of a dichotomous property with a simple single parameter clumping is suggested. (chalmers.se)
Scope1
- If this situation were not enough, one should also effects into the social, medical, philosophical and consider the unfoldings to the human dignity of the religious scope. (bvsalud.org)
Outcome1
- Of tese sperm + %success 36 7 18 35 14 23 53 54 ls mean score 30 same as for general anaesthesia in renal transplant recipients and those treated with testosterone for growth hormone secretion in for gynecomastia and significant effect on outcome. (gatech.edu)
Behavioral2
- Other effects classify decreased lung activity and behavioral difficulties (Domain Constitution Configuration, 2011). (daubnet.com)
- This showed that male sex endocrines had both physiological and behavioral effects, in rats at least. (studyhippo.com)
Patients1
- J. pies a unique position to confirm or exclude patients with ed who are affected by klinefelter unbalanced chromosomal complements in the 2. (gatech.edu)
Risk3
- Are many short-term and drugs that relieve some side effects but potentiate other risk factors as well. (lotusseedsdesign.com)
- All, they are a in a better position with acids improve endothelial function in humans at risk for atherosclerosis: A review. (lotusseedsdesign.com)
- Estimates of exposure levels posing minimal risk to humans (MRLs) have been made, where data were believed reliable, for the most sensitive noncancer effect for each exposure duration. (cdc.gov)
Parts1
- Thus, modularity is considered a key feature of biological organization that allows the modification of certain parts of organisms with minor effects on other parts, thereby contributing to evolvability [ 3 ]. (biomedcentral.com)
Biological4
- spores can be an effective biological weapon because of In this study, we used the rpoB gene as a chromosomal their high stability. (cdc.gov)
- In this essay I will be discoursing how gender can be explained from both the biological position and the societal position in order to reply the inquiry of whether sociology can in fact explain it. (studyhippo.com)
- This supports the biological position. (studyhippo.com)
- The biological position of gender is supported by those cross-cultural surveies that have found cosmopolitan characteristics of gender. (studyhippo.com)
Function1
- This regulatory potential is defined in terms of "regulatory features"-including the function of the gene and the conservation, type, and position of genetic polymorphisms-that are available for any organism. (nih.gov)
Regions1
- We have already seen a change in activity between activating the front, middle, and rear regions of the brain, as well as dosing effects. (uw.edu)
Radiation1
- Understanding the basic concepts in radiation physics, chemistry, and biology is important to the evaluation and interpretation of radiation-induced adverse health effects and to the derivation of radiation protection principles. (cdc.gov)
Health4
- the cumulative effect of social and economic exclusion on the health of mothers and their babies, whatever their age, is. (bmj.com)
- During his time at the CDC, he was the first Hispanic to attain the rank of assistant surgeon general and held a number of leadership positions focused on improving the health of mothers, children and adults in programs such as immunizations, birth defects and disabilities. (uga.edu)
- The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of pyridine and a depiction of significant exposure levels associated with various adverse health effects. (cdc.gov)
- As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
Humans1
- No useful studies were located regarding renal effects in humans after inhalation exposure to pyridine. (cdc.gov)
Investigations1
- Genetic and metabolic investigations for neurodevelopmental disorders: position statement of the Canadian College of Medical Geneticists (CCMG). (cdc.gov)
Points1
- The points in the figures showing noobserved-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)