A coronary vasodilator agent.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
The thermodynamic interaction between a substance and WATER.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
A plant genus of the family APIACEAE. It contains pungent oils and resins. It is used to flavor curries, as a carminative, and as cat and dog repellent. The occasionally used common name of 'giant fennel' should not be confused with true fennel (FOENICULUM).
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.
A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.
A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
The veins and arteries of the HEART.
The circulation of blood through the CORONARY VESSELS of the HEART.
Behavior in which persons hurt or harm themselves without the motive of suicide or of sexual deviation.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
A plant genus of the family ERICACEAE. The common name of "wintergreen" is also used for PYROLA and "snowberry" is also used for SYMPHORICARPOS.
A physiologically diverse phylum of acidophilic, gram-negative bacteria found in a wide variety of habitats, but particularly abundant in soils and sediments.
Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
An isoenzyme of creatine kinase found in the MUSCLE.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. (1/14)

1. The aim of the present study was to investigate the effects of cloricromene, a coumarine derivative, in rats subjected to collagen-induced arthritis. 2. Collagen-induced arthritis (CIA) was induced in Lewis rats by an intradermal injection of 100 microl of the emulsion (containing 100 microg of bovine type II collagen) (CII) and complete Freund's adjuvant (CFA) at the base of the tail. On day 21, a second injection of CII in CFA was administered. 3. Lewis rats developed an erosive hind paw arthritis when immunized with CII in CFA. Macroscopic clinical evidence of CIA first appeared as peri-articular erythema and oedema in the hind paws. The incidence of CIA was 100% by day 27 in the CII challenged rats and the severity of CIA progressed over a 35-day period with radiographic evaluation revealing focal resorption of bone together with osteophyte formation in the tibiotarsal joint and soft tissue swelling. 4. The histopathology of CIA included erosion of the cartilage at the joint margins. Treatment of rats with cloricromene (10 mg kg(-1) i.p. daily) starting at the onset of arthritis (day 23), delayed the development of the clinical signs at days 24 - 35 and improved histological status in the knee and paw. 5. Immunohistochemical analysis for iNOS, COX-2, nitrotyrosine and for poly (ADP-ribose) synthetase (PARS) revealed a positive staining in inflamed joints from collagen-treated rats. The degree of staining for iNOS, COX-2, nitrotyrosine and PARS were markedly reduced in tissue sections obtained from collagen-treated rats, which had received cloricromene. 6. Radiographic signs of protection against bone resorption and osteophyte formation were present in the joints of cloricromene-treated rat. 7. This study provides the first evidence that cloricromene, a coumarine derivative, attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in the rat.  (+info)

Effect of estrogen replacement therapy on distribution of myocardial blood flow in female anesthetized rabbits. (2/14)

Estrogen replacement therapy reduces risk of cardiovascular events by altering coronary vasoregulation and distribution of blood flow. Vessel reactivity and blood flow distribution were assessed in anesthetized female rabbits in the following groups: 1) sham, 2) ovariectomy, 3) ovariectomy + 17beta-estradiol, and 4) ovariectomy + dehydroepiandrosterone. After a 2-wk treatment, cardiac hemodynamics, vascular reserve, and blood flow were evaluated during the following infusions: 1) NaCl, or vehicle (0.5 ml/min), 2) acetylcholine (2 mg/kg), 3) isoproterenol (2 mg. kg(-1). min(-1)), and 4) chromonar (8 mg/kg). In hearts from ovariectomized rabbits, autoregulatory blood flow was preserved despite lower diastolic perfusion pressures (55 +/- 8 vs. 64 +/- 8 mmHg in sham) and rate-pressure product (14.4 +/- 0.8 vs. 19.3 +/- 0.8 beats/min. mmHg x 10(-3)). Estrogen replacement therapy restored coronary pressure and reserve, and all drugs increased vascular conductance. In conclusion, in hearts from ovariectomized rabbits, vascular reserve declined because coronary pressure was lower; however, blood flow was preserved at a higher level than expected for oxygen demand. Estrogen replacement therapy restores myocardial oxygen supply-demand indices and returns coronary pressure-flow data to levels observed in animals with intact ovaries.  (+info)

Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats. (3/14)

PURPOSE: To investigate the effects of cloricromene, a coumarin derivative, in rats subjected to endotoxin-induced uveitis (EIU). METHODS: Endotoxin uveitis was induced in male Lewis rats by a single footpad injection of 200 microg lipopolysaccharide (LPS). Cloricromene was topically applied to the rat eye twice at 1 hour before and 7 hours after injection of LPS. A separate group of animals was treated with vehicle. Rats were killed 16 hours after injection and the eyes enucleated for histologic examination and immunohistochemical analysis. The effect of treatment was also evaluated by slit lamp examination, by the number of intraocular inflammatory cells on histologic sections, and by measuring the protein and TNFalpha levels in the aqueous humor. Nitrite and nitrate production was also measured in the aqueous humor. RESULTS: The histopathology of the iris-ciliary body included inflammatory cell infiltration and nuclear modification of vessel endothelial cells. Cloricromene treatment reduced the inflammatory cell infiltration and improved histologic status of the ocular tissue. Immunohistochemical analysis for P-selectin, intracellular adhesion molecule (ICAM)-1, nitrotyrosine, and poly(ADP-ribose) synthetase (PARS) revealed a positive staining in inflammatory cell infiltration from LPS-treated rats. The degree of staining for P-selectin, ICAM-1, nitrotyrosine, and PARS was markedly reduced in tissue sections obtained from LPS-recipient rats that had received cloricromene. Cloricromene strongly inhibited cell infiltration, protein exudation, TNFalpha production, and nitrite-nitrate formation. CONCLUSIONS: This study provides the first evidence that cloricromene, a coumarin derivative, attenuates the degree of inflammation and tissue damage associated with EIU in rats.  (+info)

Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene. (4/14)

The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle suspensions were made using inert polymer resins (Eudragit RS100 and RL100). We modified the quasi-emulsion solvent diffusion technique by varying some formulation parameters (the drug-to-polymer ratio, the total drug and polymer amount, and the stirring speed). The chemical stability of AD6 in the nanosuspensions was assessed by preparing some formulations using (unbuffered) isotonic saline or a pH 7 phosphate buffer solution as the dispersing medium. The formulations were stored at 4 degrees C, and the rate of degradation of AD6 was followed by high performance liquid chromatography (HPLC). The obtained nanosuspensions showed mean sizes and a positive surface charge (zeta-potential) that make them suitable for an ophthalmic application; these properties were maintained upon storage at 4 degrees C for several months. In vitro dissolution tests confirmed a modified release of the drug from the polymer matrixes. Nanosuspensions prepared with saline solution and no or lower amounts of surfactant (Tween 80) showed an enhanced stability of the ester drug for several months, with respect to an AD6 aqueous solution. Based on the technological results, AD6-loaded Eudragit Retard nanoparticle suspensions appear to offer promise as a means to improving the shelf life and bioavailability of this drug after ophthalmic application.  (+info)

Protective effects of a coumarin derivative in diabetic rats. (5/14)

 (+info)

Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins. (6/14)

 (+info)

Decreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits. (7/14)

Watanabe heritable hyperlipidemic (WHHL) rabbits have severe hypercholesterolemia due to a genetic defect in their low density lipoprotein receptors. Therefore, they develop severe premature atherosclerosis of the large arteries including the coronary arteries. In the present study, we measured the coronary vascular reserve of these rabbits to evaluate the total cross-sectional coronary surface area. This method allowed us to quantify the functional consequences of the coronary atherosclerotic lesions. To evaluate coronary vascular reserve, we measured coronary blood flow with the radioactive microsphere technique before and after induction of maximal coronary vasodilation by an intravenous dose of 9 mg/kg of carbocromen. A group of pure-bred WHHL rabbits was compared to a group of normal Burgundy rabbits at ages of 100 and 300 days. At 100 days, there was no difference in coronary vascular reserve between the two groups. However, at 300 days, the coronary vascular reserve in WHHL rabbits was 48% smaller than in the normal Burgundy rabbits (p less than 0.001). In addition, by making corrosion casts and morphological studies, we were able to show that at 300 days nearly all the WHHL rabbits had severe coronary atherosclerotic lesions located mainly at the origin of the large coronary arteries. We conclude that WHHL rabbits at 300 days have a severe impairment of their coronary vascular reserve due to proximal atherosclerotic lesions in the coronary arteries.  (+info)

Thyroxine-induced hypertrophy of the rabbit heart. Effect on regional oxygen extraction, flow, and oxygen consumption. (8/14)

The effects of the administration of 0.5 or 1 mg/kg of 1-thyroxine for 3 or 16 days were studied in 55 New Zealand white rabbits. Heart size was 29% above control after 16 days of 1-thyroxine, despite lower body weights. In an anesthetized open-chest animal, regional microspectro-photometric observations of small arteries and veins to determine oxygen extraction were combined with regional blood flow measurements using radioactive microspheres to determine regional oxygen consumption by the Fick principle. Vascular flow reserves were studied through measurement of blood flow after the administration of chromonar HCl, 10 mg/kg. Myocardial oxygen consumption was, respectively, 2.4 and 3.8 times control after 3 and 16 days of 1-thyroxine. This was accompanied by significant increases in both coronary blood flow and oxygen extraction. In control, oxygen extraction and consumption were higher in the subendocardial region compared to the subepicardial area. No significant regional differences were found in flow, oxygen extraction, or consumption after 1-thyroxine administration. Chromonar increased coronary blood flow 2.8 times in the control animals, but did not significantly increase flow or decrease vascular resistance in the rabbits given 1-thyroxine. Adenosine increased coronary blood flow 3.5 times in the control animals but only 2.2 times in animals given 1-thyroxine for 3 days. Animals given 1-thyroxine had hypertrophied hearts with increased oxygen consumption, markedly increased flow, and increased oxygen extraction but without regional left ventricular differences.  (+info)

M. Barradas, M.A. Khokher, R.A. Hutton, I.L. Craft, P. Dandona; Platelet Antiaggregatory Activity of Normal Placentae: Conversion of ADP to Adenosine. Clin Sci (Lond) 1 September 1982; 63 (3): 75P-76P. doi: https://doi.org/10.1042/cs063075Pb. Download citation file:. ...
We examine the effects of nonlinear diode junction capacitance on the fundamental premise of the noise-to-nose calibration, that the kickout is identical in sha
Our group evaluated simultaneously the RV systolic reserve (TAPSE, S, myocardial acceleration during isovolumic contraction, IVA) and the pulmonary vascular reserve (arterial stiffness) using low-dose of dobutamine (10mg/kg/min) plus a 30° Trendelenburg position and its impacts on the outcome during a two year follow-up in patients with PAH. We demonstrated that global reserve of the RV-PCU was impaired in PAH patients, showing the higher increase in delta EM, higher mPAP-CO ratio, with a negative change in delta SV and a positive change in delta PVR and TPR. While delta EM correlated with delta mPAP, delta S and delta IVA correlated with CO, therefore the stress response of mPAP and CO would be in relation with the pulmonary vascular reserve and systolic RV reserve, respectively. The lower recruitable reserve of the RV-PCU was significantly related to a worse hemodynamic response to stress testing showing a higher dobutamine-induced mPAP-CO slope, and it could be associated with poor ...
This technology contains a coating of Glass panel on top of that there is a thin coating, which stores a continuous electric charge. In the touch on the screen some of this charge passes on to the consumer. This reduces the capacitance on the display at the point, which can be detected by the computer and calculated to comprehend the action. These are incredibly durable and are widely utilized in POS systems, Kiosks, and industrial technologies. Additionally, it has been availed in high-end mobile tablet computer technologies in the market today. You cannot activate a capacitive screen with a stylus or gloved fingers.. In fact, the technology behind the Touch display can actually traced right back into the 1940s but it was just two years later that it actually became possible to utilize on a big scale.. A roll to roll evaporator system From industry leading manufacturers are able to mass produce ITO signature film which can be used on various devices like smart phones, LCD or LED displays, ...
Fluorescent Dye derived from coumarine. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0097) - Products - Abnova
HALO VITA GLO DAILY GREENS 100 TABLETS - A formula designed with essential nutrients including a blend of enzymes and chlorophyllins.
K2CO3 was utilized as an friendly catalyst for the environmentally fast and simple synthesis of ten 3-substituted coumarin derivatives by the Knoevenagel condensation of salicylaldehyde and its derivatives with diethyl malonate, ethyl acetoaceate or methyl acetoaceate under solvent free conditions. Three effect on the yield of coumarin-3-ethyl formate was investigated. The results showed that coumarin-3-ethyl formate were obtained 88.1% yields within based on 20 mmol of salicylaldehyde, molar ratio of salicylaldehyde to diethyl malonate 1:1.2, dosage of K2CO3 0.1 mmol and time of reaction 15-18 min. When ethyl (or methyl) acetoaceate displaces diethyl malonate, 3-acetyl coumarin were synthesized with the yield 84.7%(or 82.9%). When solid substituted salicylaldehyde displaces salicylaldehyde with diethyl malonate, ethyl (or methyl) acetoacetate at a mole ratio of 1:2.0, eight 3-substituted coumarin derivatives were synthesized with the yield from 62.5%-89.0%(or ...
Effect of synthetic coumarin derivatives on HT1080 fibrosarcoma cell invasion. Chemoinvasion and chemotaxis were evaluated in Transwell cell culture inserts coa
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
4-Hydroxy coumarin (1.0 mole) and potassium carbonate (1.5 mole) in DMF (3 vol) as a solvent media was heated up to 75 °C and solution of 3-methyl-1-phenyl-1 H-pyrazol-5(4H)-one (1.0 mole) in DMF (2 vol) at 75 °C was added. The reaction mass stirred for 5 h at 75 °C (TLC monitoring: hexane/ethyl acetate 5:5, Rf = 0.47). After the completion of reaction, the product was obtained by adjusting the pH at 4-5 by HCl. It was filtered, dried and recrystallized from ethyl acetate and hexane to give the 4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (6).. Light cream crystal. Yield 73 %, m.p. 153-157 °C, IR (KBr, cm-1) (Fig. S15): 1631 cm-1 (C=O), 3084-3176 cm-1 (OH), 1375-1390 cm-1 (CH2), 759 cm-1, 775 cm-1 (substituted benzene); 1H NMR (400 MHz, DMSO) (Fig. S7)11.83 (s, 1H, OH), 7.11-8.03 (m, 9H, Ar-H), 2.76 (m, 1H, CH), 2.18-2.19 (s, 3H, CH3); C19H14N2O4 (334.32); Found (C-68.16, H-4.29, N-8.37 %) requires (C-68.26, H-4.22, O-19.14, N-8.40 %) MS: m/z: 335.4 ...
Highly functionalized pyrrolidines have gained much interest in the past few years as they constitute the main structural element of many natural and synthetic pharmacologically active compounds (Waldmann, 1995). Optically active pyrrolidines have been used as intermediates, chiral ligands or auxiliaries in controlled asymmetric synthesis (Suzuki et al., 1994; Huryn et al., 1991). In view of this importance, the crystal structure of the title compound has been carried out and the results are presented here.. The title compound consists of a pyrrolidine ring connected to a oxindole ring system at C1, a coumarine moiety at C2 and a benzene ring at C3. The X-ray analysis confirms the molecular structure and atom connectivity as illustrated in Fig.1.. The pyrrolidine (N1/C1-C4) ring adopts a twist conformation , with twist about the C4-N1 bond; the puckering parameters (Cremer & Pople, 1975), q2 = 0.4216 (14) Å and ϕ2 = 156.9 (2)°, and asymmetry parameters (Duax et al., 1976) ΔC2[C4-N1] = 5.0 ...
Andrew Ko, MD, provides his perspective on PEGPH20 given the phase III HALO-301 trial and potential drug combinations in the setting of pancreatic adenocarcinoma.
Headstage includes an attached twisted pair digital tether and µDB25 connector, and video tracking LED sockets. For use with Halo-18, Harlan 12 and Harlan 28 microdrives.. The HS-64-mux headstage consists of two 32 channel mux headstages connected to a single tether at the Y junction close to the headstages. Combine analog and digital (MUX) headstages on Digital Lynx SX-M systems.. ...
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray New Talent: Europe
Electrochemical sensing methods have the great potential to achieve simple, sensitive, selective, and cost-effec-tive detection of biomolecules to diagnose and monitor various diseases. In this regard, we have developed DNA and protein diagnostic system based on electrochemical analytical method. In chapter 2, we developed a novel alkaline phosphatase (ALP) determination system based on the $Cu^{2+}$-mediated oxidation which could be detected by impedimetric detection method. It causes change of the interfacial properties of the electrodes and increased interfacial electron-transfer resistance is detected by electrochemical impedance spectroscopy (EIS). In chapter 3, we have developed a novel strategy to achieve label-free multiplex DNA detection system based on the projected capacitive touchscreen. The hybridization event significantly enhanced the capacitance on the electrode, which can be very conveniently detected by the projected capacitive touchscreen. In chapter 4, we developed an ...
The market for methyl acetoacetate was mainly driven by end-user industries such as pharmaceutical, agrochemicals and solvents among others.Methyl acetoacetate is used as a starting material in the production of cyclic compounds such as coumarine and pyrazole.This research report analyzes this market on the basis of its market segments, major geographies, and current market trends.
In one dead dosed with 2,000 mg/kg, irregular respiration and compound-colored stool were evident on the day of dosing and on Day 1 after dosing. Irregular respiration decrease of fecal volume, hypothermia, incised wound (left forelimb, right forelimb), paleness, refusal to feed, scratched wound (abdomen), self biting and in a state of lying on side were evident on Day 2 after dosing. Then, one animal was found dead on Day 2 after dosing. In five surviving animals at 2,000 mg/kg, irregular respiration was evident on the day of dosing. In three surviving animals at 2,000 mg/kg, irregular respiration and/or compound-colored stool were evident from Day 1 to Day 2 after dosing. Then, these animals returned to a normal appearance on Day 3 after dosing. In two surviving animals at 2,000 mg/kg, irregular respiration, compound-colored stool, decrease of fecal volume, hypothermia, incised wound (left forelimb, right forelimb), paleness, decrease in food consumption, blackish stool, piloerection and/or ...
My Lasik Dr also mentioned an enhancement may be an option. I expressed that I did not wish to risk my day time vision. He was sympathetic to this. He asked for another wavefront diagnostic to be carried out, which was also performed today. This was a surprise to the technician, and I got the impression she isnt often asked to perform this test after Lasik and better than 20/20 vision is gained. Technician said wavefront analysis looked good, and she actually asked me do the starbursts/halos bother you that much?. A single word response answer - Yes ...
My Lasik Dr also mentioned an enhancement may be an option. I expressed that I did not wish to risk my day time vision. He was sympathetic to this. He asked for another wavefront diagnostic to be carried out, which was also performed today. This was a surprise to the technician, and I got the impression she isnt often asked to perform this test after Lasik and better than 20/20 vision is gained. Technician said wavefront analysis looked good, and she actually asked me do the starbursts/halos bother you that much?. A single word response answer - Yes ...
Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnkes reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.
Interactions of several 7-aminocoumarins with human serum albumin (HSA) were studied by using fluorescence spectroscopic technique and modeling studies. There is a large change in fluorescence spectral parameters like intensity, emission maxima and anisotropy for all aminocoumarins. There were two binding sites for cou-1, 311 and a single binding site for other coumarins. The binding constant(s) are large for all coumarins reflective of a strong binding. These spectral studies show that structural variants at the third, fourth and seventh position affects binding. The probable location of these coumarins in domain Ii has been predicted based on modeling. The effect of structural modification on the efficiency of binding was obtained for various other coumarins, using modeling.. ...
Block copolymer-based (BCP) ion gels are a class of interesting solid polymer electrolytes (SPEs) in electrochemical applications. This thesis aims to systematically study the mechanical and electrical properties of BCP-based ion gels formed by the selfassembly of ABA triblock copolymers in an ionic liquid, and find ways to enhance the properties of the gels, in order to formulate optimal designs in terms of the triblock for applications to electrochemical devices. Two particular target applications are organic transistors and electrochemical capacitors, due to the very large specific capacitance (on the order of F/cm2) of these electrolytes and therefore low voltage operation and potentially desirable energy storage. To study the effect of the BCP on the properties of ion gels, BCPs with different midblocks and end-block lengths were prepared, and the viscoelastic and electrical properties of the ion gels were investigated over large composition and temperature ranges. The gels were formed ...
TY - JOUR. T1 - Evidence of endothelial dysfunction in the development of Alzheimers disease. T2 - Is Alzheimers a vascular disorder?. AU - Kelleher, Rory J.. AU - Soiza, Roy L. N1 - Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship. The authors are grateful to Alzheimers Research UK for providing funding. PY - 2013/11/15. Y1 - 2013/11/15. N2 - The etiology of Alzheimers disease (AD) remains unclear. The emerging view is that cerebrovascular dysfunction is a feature not only of cerebrovascular diseases, such as stroke, but also of neurodegenerative conditions, such as AD. In AD, there is impaired structure and function of cerebral blood vessels and cells in the neurovascular unit. These effects are mediated by vascular oxidative stress. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier and reduces the brains repair capacity. Such injury can exacerbate the cognitive dysfunction exerted ...
0201] Particularly preferred compounds of the formula M are those in which [0202] RMa and RMb each, independently of one another, denote P, P-Sp-, H, F, Cl, Br, I, --CN, --NO2, --NCO, --NCS, --OCN, --SCN, SF5 or straight-chain or branched alkyl having 1 to 25 C atoms, in which, in addition, one or more non-adjacent CH2 groups may each be replaced, independently of one another, by --C(R0)═C(R0)--, --C≡C--, --N(R00)--, --O--, --S--, --CO--, --CO--O--, --O--CO--, --O--CO--O-- in such a way that O and/or S atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by F, Cl, Br, I, CN, P or P-Sp-, where at least one of the radicals RMa and RMb preferably denotes or contains a group P or P-Sp-, [0203] AM1 and AM2 each, independently of one another, denote 1,4-phenylene, naphthalene-1,4-diyl, naphthalene-2,6-diyl, phenanthrene-2,7-diyl, anthracene-2,7-diyl, fluorene-2,7-diyl, coumarine, flavone, where, in addition, one or more CH groups in these ...
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push-pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin ...
Looking for Marevan? Find out information about Marevan. anticoagulant anticoagulant , any of several substances that inhibit blood clot formation . Some anticoagulants, such as the coumarin derivatives... Explanation of Marevan
Hormonal 6 Epsilon -lower alkanoylthio-3-oxo-4-en-steroids are prepared from corresponding 6 Epsilon -halo-3-oxo-delta-4steroids and 6 Epsilon -lower alkanoylthio-5-hydroxy-3-oxosteroids. They are also useful as intermediates for synthesis of hormonal thieno-(4,3,2-4,5,6,)steroids which have been disclosed in U.S. Pat. No. 3,300,485.
This randomized phase II trial provides further rationale supporting a compelling explanation for at least part of this resistance, namely very high interstitial concentrations of hyaluronan, he continued. These data also support the use of tumor HA as a potential predictive biomarker for patient selection in the ongoing, global phase III study of PAG versus AG in patients with HA-high PDA.. The HALO-202 trial was conducted in two stages. In stage 1 (March 2013 to April 2014), 146 patients were randomized 1:1 to receive PAG or AG -- but researchers observed an imbalance in thromboembolic events early in the study. The trial was subsequently put on hold and 29 patients receiving PAG continued treatment with AG alone. Seven of these patients went back on PEGPH20 therapy when stage 2 of the trial started (August 2014 to February 2016) with an amended protocol.. In stage 2, patients with thromboembolic events were excluded, enoxaparin (Lovenox) prophylaxis was initiated in both arms, and an ...
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
http://jazzyjoe.byethost13.com/content/range-wolf.html range wolf] [http://chuchundramc.marte.ro/view/halo-.html halo 2 costume] [http://antimil.uv.ro/small/free-chat.html free chat web cam] [http://robotqueen.uv.ro/library/cheap-paintball/ cheap paintball guns] [http://bervera.talk4fun.net/description/when-to/ when to use to or too] [http://astw56.uv.ro/styles/pretty-women/ pretty women] [http://astw56.uv.ro/styles/olympic-airways/ olympic airways] [http://robotqueen.uv.ro/library/house-for/ house for rent] [http://robotqueen.uv.ro/library/sportsbook/ sportsbook] [http://oktagudent.totalh.com/view/softwares-downloading/ softwares downloading] [http://kasumikawaii.byethost13.com/articles/install-jre/ install jre on linux] [http://robotqueen.uv.ro/library/asian-movies/ asian movies] [http://antimil.uv.ro/small/big-houses.html big houses] [http://oktagudent.totalh.com/view/apartment-dc/ apartment dc search washington] [http://thedrea.uv.ro/text/movado-watches/ movado watches] ...
ASL perfusion MR imaging was first described over a decade ago12,13 and has been an active area of research.14,15 One advantage of ASL over conventional bolus tracking for perfusion measurement is that it provides absolute CBF information. Quantification of CBF facilitates the identification of cases with symmetric global perfusion abnormalities (Fig 2).. Causes of global cerebral hyperperfusion include etiologies that result in global vasodilation or loss of cerebral vascular autoregulation. Carbon dioxide is a potent vasodilator, and hypercapnia can cause transient vasodilation when cerebral perfusion autoregulation pathways are intact.16-19 This property has been exploited with tests, such as the hypercapnia challenge, to evaluate the cerebral vascular reserve.17 All of the patients in our series had normal arterial blood gas measurements except for case 6. Case 6 is a case of favorable outcome while showing global hyperperfusion. Previous studies have shown up to a 200% increase in CBF as ...
The only frequent adverse reaction during therapy with oral anticoagulants is bleeding due to depression of vitamin K-dependent hepatic clotting proteins. Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign events such as gastrointestinal dysfunction, hypersensitivity dermatitides, drug fever, and alopecia. Only one serious complication remains poorly understood: coumarin necrosis of skin and subcutaneous tissue. Widely reported in Europe (1-10) it has received little attention in English-speaking countries (11-14) and is still being misinterpreted as a hemorrhagic effect.. Although clinical use of bishydroxycoumarin began in 1940, coumarin necrosis was not recognized until ...
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
ly words (1) Bloody Mary (1) Dark and stormy night (1) #inlandstrong (1) 000 Words from your Story (1) 10 Things I Thought Id Never Say (1) 100th follower (1) 17th of Nisan (1) 1800s (1) 1925 Model T Ford (1) 2 Timothy 1 (1) 2009 ACFW Genesis winner (1) 2011 ACFW conference (7) 2011 MBT WriMo (2) 2011 NaNoWriMo (4) 2011 sneak peek (1) 2011 Writers Covenant (2) 2012 ACFW Conference (3) 2012 Olympic Games (1) 2013 ACFW conference (4) 2014 (3) 2014 ACFW Conference (1) 3G Kindle Touch (1) 4 Key Truths for Writers (1) 4 rules for editing your writing (1) 4 tip for editing (1) 41 Will Come (1) 4th of July (3) 5 editing tips and a pet peeve (1) 60 seconds (1) 7th century (1) 9/11 (2) A Christmas Carol (2) A Door County Christmas (1) A Fish Out of Water (1) A Hope Undaunted (1) A Muppet Christmas Carol (1) A Passion Most Pure (1) A Promise to Protect (1) a sound mind (1) a tale of two cities (2) A Visit From Sandra Orchard (1) A Word Fitly Spoken (1) A Writers Imagination (1) a writers life (5) ...
About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
Abstract: The anion-templated synthesis of three novel halogen-bonding 5-halo-1,2,3-triazolium axle containing [2]rotaxanes is described, and the effects of altering the nature of the halogen-bond donor atom together with the degree of inter-component preorganisation on the anion-recognition properties of the interlocked host investigated. The ability of the bromotriazolium motif to direct the halide-anion-templated assembly of interpenetrated [2]pseudorotaxanes was studied initially; bromide was found to be the most effective template. As a consequence, bromide anion templation was used to synthesise the first bromotriazolium axle containing [2]rotaxane, the anion-binding properties of which, determined by 1H NMR spectroscopic titration experiments, revealed enhanced bromide and iodide recognition relative to a hydrogen-bonding protic triazolium rotaxane analogue. Two halogen-bonding [2]rotaxanes with bromo- and iodotriazolium motifs integrated into shortened axles designed to increase ...
Description of disease ERT (estrogen replacement therapy). Treatment ERT (estrogen replacement therapy). Symptoms and causes ERT (estrogen replacement therapy) Prophylaxis ERT (estrogen replacement therapy)
Patients receiving concomitant capecitabine and oral coumarin‐derivative anticoagulant therapy should have their anticoagulant response (INR or prothrombin time) monitored frequently in order to adjust the anticoagulant dose accordingly. A clinically important capecitabine‐warfarin drug interaction was demonstrated in a clinical pharmacology trial. Altered coagulation parameters and/or bleeding, including death, have been reported in patients taking capecitabine concomitantly with coumarin‐derivative anticoagulants such as warfarin and phenprocoumon. Post‐marketing reports have shown clinically significant increasesin prothrombin time and INR in patients who were stabilised on anticoagulants at the time capecitabine was introduced. These events occurred within several days and up to several months after initiating capecitabine therapy and, in a few cases, within 1 month after stopping capecitabine. These events occurred in patients with and without liver metastases. Age greater than 60 ...
Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leucocytes.: Recent data [Lopéz-Farré, Riesco, Moliz, Egido, Casado, Hernand
TY - JOUR. T1 - Protective effects of relaxin in ischemia/reperfusion-induced intestinal injury due to splanchnic artery occlusion. AU - Masini, Emanuela. AU - Cuzzocrea, Salvatore. AU - Mazzon, Emanuela. AU - Muià, Carmelo. AU - Vannacci, Alfredo. AU - Fabrizi, Francesca. AU - Bani, Daniele. PY - 2006/8/24. Y1 - 2006/8/24. N2 - 1 Splanchnic artery occlusion (SAO) followed by reperfusion causes endothelial injury and inflammation which contribute to the pathophysiology of shock. We investigated the effects of relaxin (RLX), known to afford protection against the deleterious effects of cardiac ischemia/reperfusion, given to rats subjected to splanchnic artery occlusion and reperfusion (SAO/R)-induced splanchnic injury. 2 RLX (30 ng kg -1, 15 min. before reperfusion) significantly reduced the drop of blood pressure and high mortality rate caused by SAO/R. RLX also reduced histopathological changes, leukocyte infiltration (myeloperoxidase) and expression of endothelial cell adhesion molecules in ...
The dielectric constant and the conductivity for several organic solvents of varying polarity and for colloidal suspensions are measured using dielectric spectroscopy as a function of frequency, over the frequency range 0.1 Hz to 100 kHz. These measurements are carried out for organic solvents of different polarities: cyclohexyl bromide (CHB), castor oil, cis+trans-decahydronaphtalene (decalin) and decane. In addition, dielectric spectroscopy is carried out for polymethylmethacrylate (PMMA) colloidal spheres in the intermediate polar mixture of cyclohexy bromide (C₆ H₁₁ Br,(CHB)) and 20% cis+trans-decalin by volume. The primary result in this thesis is the examination of electrode polarization effects, which were observed at low frequency in CHB and CHB-decalin mixtures. A simple model function for sample impedance coupled with electrode polarization, involving a power law dependance of the polarization capacitance on frequency, provided an excellent fit to the dielectric spectra at low ...
At The Bienetre Center, we use bio identical hormones for Estrogen Replacement Therapy, to bring estrogen levels back to a normal, healthy range, decreasing the symptoms you are experiencing and allowing you to experience life in a way that maybe you havent been able to for years.. After being treated with Estrogen Replacement Therapy, patients reported having better sleep, better attitudes on life and the ability to cope or handle stress better. There were also clinical improvements including fewer UTIs, a decrease in hot flashes and stronger bones.. ...
View details of top estrogen replacement therapy hospitals in Chennai. Get guidance from medical experts to select best estrogen replacement therapy hospital in Chennai
TY - JOUR. T1 - Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus. AU - Tsay, Shwu Chen. AU - Hwu, Jih Ru. AU - Singha, Raghunath. AU - Huang, Wen Chieh. AU - Chang, Yung Hsiung. AU - Hsu, Ming Hua. AU - Shieh, Fa Kuen. AU - Lin, Chun Cheng. AU - Hwang, Kuo Chu. AU - Horng, Jia Cherng. AU - De Clercq, Erik. AU - Vliegen, Inge. AU - Neyts, Johan. PY - 2013/3/18. Y1 - 2013/3/18. N2 - A new compound library that contained 20 hinged benzimidazole-coumarin hybrids and their β-d-ribofuranosides was established. The anti-hepatitis C virus (HCV) activity of all novel coumarin derivatives, which were obtained by use of organic synthetic methods, was tested. Two of these hybrids exhibited appealing EC50 values of as low as 3.0 and 5.5 μM. The best selectivity index was 14. The incorporation of a d-ribofuranose into the hinged hybrids provided the corresponding nucleosides with the β configuration, one of which inhibited HCV replication with an EC50 value ...
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity ...
Warfarin is a modern slow-kill repeat-bait poison and among the safest and most effective rat poisons in common use. Warfarin was discovered after Canadian cattle ate improperly stored sweet clover and began to hemorhage and die. In 1930 the active ingredient coumarin was isolated from this clover. In 1940 the Wisconsin Alumni Research Foundation patented a coumarin compounded called Warfarin (named after the foundations initials). In 1952 warfarin was first used as an anticoagulant on humans, and today it (or some other coumarin derivative) is used by patients with artificial heart valves or who are in danger of thrombosis (blood clots). When used as a rodenticide, warfarin should be set out in feed-on-demand bait stations for at least two weeks. Other anticoagulants that work about the same as warfarin are brodifacoum, bromadiolone, chlorophacinone, diphacinone, fumarin, pival, and PMP. Some rat and mouse populations have become resistant to warfarin and other anti-coagulants -- a good ...
Hello, Estrogen replacement therapy is the substitution of estrogen when natural production is low due to any reason including hysterosalpingo-oophorectomy due to carcinoma. I am not sure what is it made from but it has complete natural properties like estrogen produced in the body. Hope I have...
Affordable Estrogen Replacement Therapy in Mexico. Helping adult woman compensate the low production of estrogen in their body. Contact us today!
Neuroinflammation plays a vital role in Alzheimers disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential roles in the maintenance of homeostasis and responses to neuroinflammation. The orphan G-protein-coupled receptor 55 (GPR55) has been reported to modulate inflammation and is expressed in immune cells such as monocytes and microglia. However, its effects on neuroinflammation, mainly on the production of members of the arachidonic acid pathway in activated microglia, have not been elucidated in detail. In this present study, a series of coumarin derivatives, that exhibit GPR55 antagonism properties, were designed. The effects of these compounds on members of the arachidonic acid cascade were studied in lipopolysaccharide (LPS)-treated primary rat microglia using Western blot, qPCR, and ELISA. We demonstrate here that the various compounds with GPR55 antagonistic activities significantly inhibited the
Bioidentical Estrogen replacement therapy in Annapolis, MD. Optimize your estrogen levels with help from a hormone doctor in Annapolis, MD.
Bioidentical Estrogen replacement therapy in Roswell, GA. Optimize your estrogen levels with help from a hormone doctor in Roswell, GA.
Among its many salutary effects, estrogen seems to protect the brain against the ravages of Alzheimers disease: numerous clinical studies support that finding.
大阪府立看護大学/大阪府立看護大学/大阪府立看護大学/大阪府立看護大学医療技術短期大学部/大阪府立看護大学医療技術短期大学部/大阪府立看護大学医療技術短期大学部/元大阪府立羽曳野病院/元大阪府立看護大学医療技術短期大学部 (1997 from CiNii) ...
高齢者および住宅歯科医療のための材料・術式の研究開発に関する一考察 -喪失歯牙補綴物の将来推計量からみた必要性- (1999 ...
Chromonar [D03.383.663.283.446.280] Chromonar * Coumestrol [D03.383.663.283.446.350] Coumestrol * Esculin [D03.383.663.283. ...
  • POTENT coronary vasodilators, including adenosine, chromonar, and dipyridamole, have been shown to cause myocardial ischemia via a "coronary steal" mechanism, which is defined as marked redistribution of myocardial blood flow from ischemic to normal zones or from subendocardial to subepicardial areas during constant aortic perfusion pressure and heart rate. (asahq.org)
  • Many preparations, for example, chromonar (Intensain), not only strengthen coronary blood flow but also improve metabolic processes in the heart, reduce the oxygen requirement of the myocardium, and strengthen collateral circulation. (thefreedictionary.com)

No images available that match "chromonar"