Chromonar: A coronary vasodilator agent.Diagnosis-Related Groups: A system for classifying patient care by relating common characteristics such as diagnosis, treatment, and age to an expected consumption of hospital resources and length of stay. Its purpose is to provide a framework for specifying case mix and to reduce hospital costs and reimbursements and it forms the cornerstone of the prospective payment system.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Dry Eye Syndromes: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Coronary Vessels: The veins and arteries of the HEART.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Self-Injurious Behavior: Behavior in which persons hurt or harm themselves without the motive of suicide or of sexual deviation.AzetidinesPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Sterols: Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)Phytosterols: A class of organic compounds known as STEROLS or STEROIDS derived from plants.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Micelles: Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.Dioctyl Sulfosuccinic Acid: All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Acidobacteria: A physiologically diverse phylum of acidophilic, gram-negative bacteria found in a wide variety of habitats, but particularly abundant in soils and sediments.Immunoglobulin Light Chains: Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Creatine Kinase, MM Form: An isoenzyme of creatine kinase found in the MUSCLE.

Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. (1/14)

1. The aim of the present study was to investigate the effects of cloricromene, a coumarine derivative, in rats subjected to collagen-induced arthritis. 2. Collagen-induced arthritis (CIA) was induced in Lewis rats by an intradermal injection of 100 microl of the emulsion (containing 100 microg of bovine type II collagen) (CII) and complete Freund's adjuvant (CFA) at the base of the tail. On day 21, a second injection of CII in CFA was administered. 3. Lewis rats developed an erosive hind paw arthritis when immunized with CII in CFA. Macroscopic clinical evidence of CIA first appeared as peri-articular erythema and oedema in the hind paws. The incidence of CIA was 100% by day 27 in the CII challenged rats and the severity of CIA progressed over a 35-day period with radiographic evaluation revealing focal resorption of bone together with osteophyte formation in the tibiotarsal joint and soft tissue swelling. 4. The histopathology of CIA included erosion of the cartilage at the joint margins. Treatment of rats with cloricromene (10 mg kg(-1) i.p. daily) starting at the onset of arthritis (day 23), delayed the development of the clinical signs at days 24 - 35 and improved histological status in the knee and paw. 5. Immunohistochemical analysis for iNOS, COX-2, nitrotyrosine and for poly (ADP-ribose) synthetase (PARS) revealed a positive staining in inflamed joints from collagen-treated rats. The degree of staining for iNOS, COX-2, nitrotyrosine and PARS were markedly reduced in tissue sections obtained from collagen-treated rats, which had received cloricromene. 6. Radiographic signs of protection against bone resorption and osteophyte formation were present in the joints of cloricromene-treated rat. 7. This study provides the first evidence that cloricromene, a coumarine derivative, attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in the rat.  (+info)

Effect of estrogen replacement therapy on distribution of myocardial blood flow in female anesthetized rabbits. (2/14)

Estrogen replacement therapy reduces risk of cardiovascular events by altering coronary vasoregulation and distribution of blood flow. Vessel reactivity and blood flow distribution were assessed in anesthetized female rabbits in the following groups: 1) sham, 2) ovariectomy, 3) ovariectomy + 17beta-estradiol, and 4) ovariectomy + dehydroepiandrosterone. After a 2-wk treatment, cardiac hemodynamics, vascular reserve, and blood flow were evaluated during the following infusions: 1) NaCl, or vehicle (0.5 ml/min), 2) acetylcholine (2 mg/kg), 3) isoproterenol (2 mg. kg(-1). min(-1)), and 4) chromonar (8 mg/kg). In hearts from ovariectomized rabbits, autoregulatory blood flow was preserved despite lower diastolic perfusion pressures (55 +/- 8 vs. 64 +/- 8 mmHg in sham) and rate-pressure product (14.4 +/- 0.8 vs. 19.3 +/- 0.8 beats/min. mmHg x 10(-3)). Estrogen replacement therapy restored coronary pressure and reserve, and all drugs increased vascular conductance. In conclusion, in hearts from ovariectomized rabbits, vascular reserve declined because coronary pressure was lower; however, blood flow was preserved at a higher level than expected for oxygen demand. Estrogen replacement therapy restores myocardial oxygen supply-demand indices and returns coronary pressure-flow data to levels observed in animals with intact ovaries.  (+info)

Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats. (3/14)

PURPOSE: To investigate the effects of cloricromene, a coumarin derivative, in rats subjected to endotoxin-induced uveitis (EIU). METHODS: Endotoxin uveitis was induced in male Lewis rats by a single footpad injection of 200 microg lipopolysaccharide (LPS). Cloricromene was topically applied to the rat eye twice at 1 hour before and 7 hours after injection of LPS. A separate group of animals was treated with vehicle. Rats were killed 16 hours after injection and the eyes enucleated for histologic examination and immunohistochemical analysis. The effect of treatment was also evaluated by slit lamp examination, by the number of intraocular inflammatory cells on histologic sections, and by measuring the protein and TNFalpha levels in the aqueous humor. Nitrite and nitrate production was also measured in the aqueous humor. RESULTS: The histopathology of the iris-ciliary body included inflammatory cell infiltration and nuclear modification of vessel endothelial cells. Cloricromene treatment reduced the inflammatory cell infiltration and improved histologic status of the ocular tissue. Immunohistochemical analysis for P-selectin, intracellular adhesion molecule (ICAM)-1, nitrotyrosine, and poly(ADP-ribose) synthetase (PARS) revealed a positive staining in inflammatory cell infiltration from LPS-treated rats. The degree of staining for P-selectin, ICAM-1, nitrotyrosine, and PARS was markedly reduced in tissue sections obtained from LPS-recipient rats that had received cloricromene. Cloricromene strongly inhibited cell infiltration, protein exudation, TNFalpha production, and nitrite-nitrate formation. CONCLUSIONS: This study provides the first evidence that cloricromene, a coumarin derivative, attenuates the degree of inflammation and tissue damage associated with EIU in rats.  (+info)

Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene. (4/14)

The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle suspensions were made using inert polymer resins (Eudragit RS100 and RL100). We modified the quasi-emulsion solvent diffusion technique by varying some formulation parameters (the drug-to-polymer ratio, the total drug and polymer amount, and the stirring speed). The chemical stability of AD6 in the nanosuspensions was assessed by preparing some formulations using (unbuffered) isotonic saline or a pH 7 phosphate buffer solution as the dispersing medium. The formulations were stored at 4 degrees C, and the rate of degradation of AD6 was followed by high performance liquid chromatography (HPLC). The obtained nanosuspensions showed mean sizes and a positive surface charge (zeta-potential) that make them suitable for an ophthalmic application; these properties were maintained upon storage at 4 degrees C for several months. In vitro dissolution tests confirmed a modified release of the drug from the polymer matrixes. Nanosuspensions prepared with saline solution and no or lower amounts of surfactant (Tween 80) showed an enhanced stability of the ester drug for several months, with respect to an AD6 aqueous solution. Based on the technological results, AD6-loaded Eudragit Retard nanoparticle suspensions appear to offer promise as a means to improving the shelf life and bioavailability of this drug after ophthalmic application.  (+info)

Protective effects of a coumarin derivative in diabetic rats. (5/14)

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Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins. (6/14)

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Decreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits. (7/14)

Watanabe heritable hyperlipidemic (WHHL) rabbits have severe hypercholesterolemia due to a genetic defect in their low density lipoprotein receptors. Therefore, they develop severe premature atherosclerosis of the large arteries including the coronary arteries. In the present study, we measured the coronary vascular reserve of these rabbits to evaluate the total cross-sectional coronary surface area. This method allowed us to quantify the functional consequences of the coronary atherosclerotic lesions. To evaluate coronary vascular reserve, we measured coronary blood flow with the radioactive microsphere technique before and after induction of maximal coronary vasodilation by an intravenous dose of 9 mg/kg of carbocromen. A group of pure-bred WHHL rabbits was compared to a group of normal Burgundy rabbits at ages of 100 and 300 days. At 100 days, there was no difference in coronary vascular reserve between the two groups. However, at 300 days, the coronary vascular reserve in WHHL rabbits was 48% smaller than in the normal Burgundy rabbits (p less than 0.001). In addition, by making corrosion casts and morphological studies, we were able to show that at 300 days nearly all the WHHL rabbits had severe coronary atherosclerotic lesions located mainly at the origin of the large coronary arteries. We conclude that WHHL rabbits at 300 days have a severe impairment of their coronary vascular reserve due to proximal atherosclerotic lesions in the coronary arteries.  (+info)

Thyroxine-induced hypertrophy of the rabbit heart. Effect on regional oxygen extraction, flow, and oxygen consumption. (8/14)

The effects of the administration of 0.5 or 1 mg/kg of 1-thyroxine for 3 or 16 days were studied in 55 New Zealand white rabbits. Heart size was 29% above control after 16 days of 1-thyroxine, despite lower body weights. In an anesthetized open-chest animal, regional microspectro-photometric observations of small arteries and veins to determine oxygen extraction were combined with regional blood flow measurements using radioactive microspheres to determine regional oxygen consumption by the Fick principle. Vascular flow reserves were studied through measurement of blood flow after the administration of chromonar HCl, 10 mg/kg. Myocardial oxygen consumption was, respectively, 2.4 and 3.8 times control after 3 and 16 days of 1-thyroxine. This was accompanied by significant increases in both coronary blood flow and oxygen extraction. In control, oxygen extraction and consumption were higher in the subendocardial region compared to the subepicardial area. No significant regional differences were found in flow, oxygen extraction, or consumption after 1-thyroxine administration. Chromonar increased coronary blood flow 2.8 times in the control animals, but did not significantly increase flow or decrease vascular resistance in the rabbits given 1-thyroxine. Adenosine increased coronary blood flow 3.5 times in the control animals but only 2.2 times in animals given 1-thyroxine for 3 days. Animals given 1-thyroxine had hypertrophied hearts with increased oxygen consumption, markedly increased flow, and increased oxygen extraction but without regional left ventricular differences.  (+info)

We examine the effects of nonlinear diode junction capacitance on the fundamental premise of the noise-to-nose calibration, that the kickout is identical in sha
Our group evaluated simultaneously the RV systolic reserve (TAPSE, S, myocardial acceleration during isovolumic contraction, IVA) and the pulmonary vascular reserve (arterial stiffness) using low-dose of dobutamine (10mg/kg/min) plus a 30° Trendelenburg position and its impacts on the outcome during a two year follow-up in patients with PAH. We demonstrated that global reserve of the RV-PCU was impaired in PAH patients, showing the higher increase in delta EM, higher mPAP-CO ratio, with a negative change in delta SV and a positive change in delta PVR and TPR. While delta EM correlated with delta mPAP, delta S and delta IVA correlated with CO, therefore the stress response of mPAP and CO would be in relation with the pulmonary vascular reserve and systolic RV reserve, respectively. The lower recruitable reserve of the RV-PCU was significantly related to a worse hemodynamic response to stress testing showing a higher dobutamine-induced mPAP-CO slope, and it could be associated with poor ...
This technology contains a coating of Glass panel on top of that there is a thin coating, which stores a continuous electric charge. In the touch on the screen some of this charge passes on to the consumer. This reduces the capacitance on the display at the point, which can be detected by the computer and calculated to comprehend the action. These are incredibly durable and are widely utilized in POS systems, Kiosks, and industrial technologies. Additionally, it has been availed in high-end mobile tablet computer technologies in the market today. You cannot activate a capacitive screen with a stylus or gloved fingers.. In fact, the technology behind the Touch display can actually traced right back into the 1940s but it was just two years later that it actually became possible to utilize on a big scale.. A roll to roll evaporator system From industry leading manufacturers are able to mass produce ITO signature film which can be used on various devices like smart phones, LCD or LED displays, ...
Fluorescent Dye derived from coumarine. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0097) - Products - Abnova
Effect of synthetic coumarin derivatives on HT1080 fibrosarcoma cell invasion. Chemoinvasion and chemotaxis were evaluated in Transwell cell culture inserts coa
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail. 7-Hydroxy-4-methylcoumarin and 4-methylcoumarin were obtained in 97% and 43% yields, respectively, over Amberlyst-15. This was the most active catalyst in the Pechmann reaction under studied conditions.
Highly functionalized pyrrolidines have gained much interest in the past few years as they constitute the main structural element of many natural and synthetic pharmacologically active compounds (Waldmann, 1995). Optically active pyrrolidines have been used as intermediates, chiral ligands or auxiliaries in controlled asymmetric synthesis (Suzuki et al., 1994; Huryn et al., 1991). In view of this importance, the crystal structure of the title compound has been carried out and the results are presented here.. The title compound consists of a pyrrolidine ring connected to a oxindole ring system at C1, a coumarine moiety at C2 and a benzene ring at C3. The X-ray analysis confirms the molecular structure and atom connectivity as illustrated in Fig.1.. The pyrrolidine (N1/C1-C4) ring adopts a twist conformation , with twist about the C4-N1 bond; the puckering parameters (Cremer & Pople, 1975), q2 = 0.4216 (14) Å and ϕ2 = 156.9 (2)°, and asymmetry parameters (Duax et al., 1976) ΔC2[C4-N1] = 5.0 ...
Andrew Ko, MD, provides his perspective on PEGPH20 given the phase III HALO-301 trial and potential drug combinations in the setting of pancreatic adenocarcinoma.
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray New Talent: Europe
Electrochemical sensing methods have the great potential to achieve simple, sensitive, selective, and cost-effec-tive detection of biomolecules to diagnose and monitor various diseases. In this regard, we have developed DNA and protein diagnostic system based on electrochemical analytical method. In chapter 2, we developed a novel alkaline phosphatase (ALP) determination system based on the $Cu^{2+}$-mediated oxidation which could be detected by impedimetric detection method. It causes change of the interfacial properties of the electrodes and increased interfacial electron-transfer resistance is detected by electrochemical impedance spectroscopy (EIS). In chapter 3, we have developed a novel strategy to achieve label-free multiplex DNA detection system based on the projected capacitive touchscreen. The hybridization event significantly enhanced the capacitance on the electrode, which can be very conveniently detected by the projected capacitive touchscreen. In chapter 4, we developed an ...
The market for methyl acetoacetate was mainly driven by end-user industries such as pharmaceutical, agrochemicals and solvents among others.Methyl acetoacetate is used as a starting material in the production of cyclic compounds such as coumarine and pyrazole.This research report analyzes this market on the basis of its market segments, major geographies, and current market trends.
My Lasik Dr also mentioned an enhancement may be an option. I expressed that I did not wish to risk my day time vision. He was sympathetic to this. He asked for another wavefront diagnostic to be carried out, which was also performed today. This was a surprise to the technician, and I got the impression she isnt often asked to perform this test after Lasik and better than 20/20 vision is gained. Technician said wavefront analysis looked good, and she actually asked me do the starbursts/halos bother you that much?. A single word response answer - Yes ...
My Lasik Dr also mentioned an enhancement may be an option. I expressed that I did not wish to risk my day time vision. He was sympathetic to this. He asked for another wavefront diagnostic to be carried out, which was also performed today. This was a surprise to the technician, and I got the impression she isnt often asked to perform this test after Lasik and better than 20/20 vision is gained. Technician said wavefront analysis looked good, and she actually asked me do the starbursts/halos bother you that much?. A single word response answer - Yes ...
Interactions of several 7-aminocoumarins with human serum albumin (HSA) were studied by using fluorescence spectroscopic technique and modeling studies. There is a large change in fluorescence spectral parameters like intensity, emission maxima and anisotropy for all aminocoumarins. There were two binding sites for cou-1, 311 and a single binding site for other coumarins. The binding constant(s) are large for all coumarins reflective of a strong binding. These spectral studies show that structural variants at the third, fourth and seventh position affects binding. The probable location of these coumarins in domain Ii has been predicted based on modeling. The effect of structural modification on the efficiency of binding was obtained for various other coumarins, using modeling.. ...
TY - JOUR. T1 - Evidence of endothelial dysfunction in the development of Alzheimers disease. T2 - Is Alzheimers a vascular disorder?. AU - Kelleher, Rory J.. AU - Soiza, Roy L. N1 - Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship. The authors are grateful to Alzheimers Research UK for providing funding. PY - 2013/11/15. Y1 - 2013/11/15. N2 - The etiology of Alzheimers disease (AD) remains unclear. The emerging view is that cerebrovascular dysfunction is a feature not only of cerebrovascular diseases, such as stroke, but also of neurodegenerative conditions, such as AD. In AD, there is impaired structure and function of cerebral blood vessels and cells in the neurovascular unit. These effects are mediated by vascular oxidative stress. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier and reduces the brains repair capacity. Such injury can exacerbate the cognitive dysfunction exerted ...
0201] Particularly preferred compounds of the formula M are those in which [0202] RMa and RMb each, independently of one another, denote P, P-Sp-, H, F, Cl, Br, I, --CN, --NO2, --NCO, --NCS, --OCN, --SCN, SF5 or straight-chain or branched alkyl having 1 to 25 C atoms, in which, in addition, one or more non-adjacent CH2 groups may each be replaced, independently of one another, by --C(R0)═C(R0)--, --C≡C--, --N(R00)--, --O--, --S--, --CO--, --CO--O--, --O--CO--, --O--CO--O-- in such a way that O and/or S atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by F, Cl, Br, I, CN, P or P-Sp-, where at least one of the radicals RMa and RMb preferably denotes or contains a group P or P-Sp-, [0203] AM1 and AM2 each, independently of one another, denote 1,4-phenylene, naphthalene-1,4-diyl, naphthalene-2,6-diyl, phenanthrene-2,7-diyl, anthracene-2,7-diyl, fluorene-2,7-diyl, coumarine, flavone, where, in addition, one or more CH groups in these ...
Looking for Marevan? Find out information about Marevan. anticoagulant anticoagulant , any of several substances that inhibit blood clot formation . Some anticoagulants, such as the coumarin derivatives... Explanation of Marevan
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push-pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin ...
Hormonal 6 Epsilon -lower alkanoylthio-3-oxo-4-en-steroids are prepared from corresponding 6 Epsilon -halo-3-oxo-delta-4steroids and 6 Epsilon -lower alkanoylthio-5-hydroxy-3-oxosteroids. They are also useful as intermediates for synthesis of hormonal thieno-(4,3,2-4,5,6,)steroids which have been disclosed in U.S. Pat. No. 3,300,485.
This randomized phase II trial provides further rationale supporting a compelling explanation for at least part of this resistance, namely very high interstitial concentrations of hyaluronan," he continued. "These data also support the use of tumor HA as a potential predictive biomarker for patient selection in the ongoing, global phase III study of PAG versus AG in patients with HA-high PDA.". The HALO-202 trial was conducted in two stages. In stage 1 (March 2013 to April 2014), 146 patients were randomized 1:1 to receive PAG or AG -- but researchers observed an imbalance in thromboembolic events early in the study. The trial was subsequently put on hold and 29 patients receiving PAG continued treatment with AG alone. Seven of these patients went back on PEGPH20 therapy when stage 2 of the trial started (August 2014 to February 2016) with an amended protocol.. In stage 2, patients with thromboembolic events were excluded, enoxaparin (Lovenox) prophylaxis was initiated in both arms, and an ...
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The only frequent adverse reaction during therapy with oral anticoagulants is bleeding due to depression of vitamin K-dependent hepatic clotting proteins. Untoward effects not related to the desired pharmacologic action of coumarin derivatives are unusual and generally benign events such as gastrointestinal dysfunction, hypersensitivity dermatitides, drug fever, and alopecia. Only one serious complication remains poorly understood: coumarin necrosis of skin and subcutaneous tissue. Widely reported in Europe (1-10) it has received little attention in English-speaking countries (11-14) and is still being misinterpreted as a hemorrhagic effect.. Although clinical use of bishydroxycoumarin began in 1940, coumarin necrosis was not recognized until ...
A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3-c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
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About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
Description of disease ERT (estrogen replacement therapy). Treatment ERT (estrogen replacement therapy). Symptoms and causes ERT (estrogen replacement therapy) Prophylaxis ERT (estrogen replacement therapy)
Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leucocytes.: Recent data [Lopéz-Farré, Riesco, Moliz, Egido, Casado, Hernand
TY - JOUR. T1 - Protective effects of relaxin in ischemia/reperfusion-induced intestinal injury due to splanchnic artery occlusion. AU - Masini, Emanuela. AU - Cuzzocrea, Salvatore. AU - Mazzon, Emanuela. AU - Muià, Carmelo. AU - Vannacci, Alfredo. AU - Fabrizi, Francesca. AU - Bani, Daniele. PY - 2006/8/24. Y1 - 2006/8/24. N2 - 1 Splanchnic artery occlusion (SAO) followed by reperfusion causes endothelial injury and inflammation which contribute to the pathophysiology of shock. We investigated the effects of relaxin (RLX), known to afford protection against the deleterious effects of cardiac ischemia/reperfusion, given to rats subjected to splanchnic artery occlusion and reperfusion (SAO/R)-induced splanchnic injury. 2 RLX (30 ng kg -1, 15 min. before reperfusion) significantly reduced the drop of blood pressure and high mortality rate caused by SAO/R. RLX also reduced histopathological changes, leukocyte infiltration (myeloperoxidase) and expression of endothelial cell adhesion molecules in ...
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The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity ...
Warfarin is a modern slow-kill repeat-bait poison and among the safest and most effective rat poisons in common use. Warfarin was discovered after Canadian cattle ate improperly stored sweet clover and began to hemorhage and die. In 1930 the active ingredient "coumarin" was isolated from this clover. In 1940 the Wisconsin Alumni Research Foundation patented a coumarin compounded called Warfarin (named after the foundations initials). In 1952 warfarin was first used as an anticoagulant on humans, and today it (or some other coumarin derivative) is used by patients with artificial heart valves or who are in danger of thrombosis (blood clots). When used as a rodenticide, warfarin should be set out in feed-on-demand bait stations for at least two weeks. Other anticoagulants that work about the same as warfarin are brodifacoum, bromadiolone, chlorophacinone, diphacinone, fumarin, pival, and PMP. Some rat and mouse populations have become resistant to warfarin and other anti-coagulants -- a good ...
Neuroinflammation plays a vital role in Alzheimers disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system, and they play essential roles in the maintenance of homeostasis and responses to neuroinflammation. The orphan G-protein-coupled receptor 55 (GPR55) has been reported to modulate inflammation and is expressed in immune cells such as monocytes and microglia. However, its effects on neuroinflammation, mainly on the production of members of the arachidonic acid pathway in activated microglia, have not been elucidated in detail. In this present study, a series of coumarin derivatives, that exhibit GPR55 antagonism properties, were designed. The effects of these compounds on members of the arachidonic acid cascade were studied in lipopolysaccharide (LPS)-treated primary rat microglia using Western blot, qPCR, and ELISA. We demonstrate here that the various compounds with GPR55 antagonistic activities significantly inhibited the
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大阪府立看護大学/大阪府立看護大学/大阪府立看護大学/大阪府立看護大学医療技術短期大学部/大阪府立看護大学医療技術短期大学部/大阪府立看護大学医療技術短期大学部/元大阪府立羽曳野病院/元大阪府立看護大学医療技術短期大学部 (1997 from CiNii) ...

Carbocromen - DrugBankCarbocromen - DrugBank

Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development.
more infohttps://www.drugbank.ca/drugs/DB13279

C-化学物质数据库C-化学物质数据库

Chromonar(Vasodilator (coronary).). *Chromotrope 2B. *Chromotropic Acid. *Chromous Acetate. *Chromous Bromide. *Chromous ...
more infohttps://www.drugfuture.com/chemdata-c.html

Integrative Medical Sciences | NEOMEDIntegrative Medical Sciences | NEOMED

We will test whether Chromonar treatment will prevent and reverse the consequences of doxorubicin treatment. We currently have ...
more infohttp://www.neomed.edu/research-faculty/student-research/summer-research-fellowship-program/ims-2/

Patente US20070155676 - Substituted azetidinone compounds, processes for preparing the same ... - Google PatentesPatente US20070155676 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes

... chromonar hydrochloride, clonitrate, diltiazem hydrochloride, dipyridamole, droprenilamine, erythrityl tetranitrate, isosorbide ...
more infohttp://www.google.es/patents/US20070155676

Patent US6497895 - Hyperbranched polymeric micelles for encapsulation and delivery of ... - Google PatentsPatent US6497895 - Hyperbranched polymeric micelles for encapsulation and delivery of ... - Google Patents

... chromonar, cilostazol, cinchonidine, citral, clinofibrate, clofaziminc, clofibrate, cloflucarban, clonitrate, clopidol, ...
more infohttp://www.google.com.au/patents/US6497895

Patente US20070155674 - Substituted azetidinone compounds, processes for preparing the same ... - Google PatentesPatente US20070155674 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes

... chromonar hydrochloride, clonitrate, diltiazem hydrochloride, dipyridamole, droprenilamine, erythrityl tetranitrate, isosorbide ...
more infohttp://www.google.es/patents/US20070155674

List of MeSH codes (D03) - WikipediaList of MeSH codes (D03) - Wikipedia

... chromonar MeSH D03.438.150.446.350 --- coumestrol MeSH D03.438.150.446.400 --- esculin MeSH D03.438.150.446.520 --- 4- ... chromonar MeSH D03.830.219.446.350 --- coumestrol MeSH D03.830.219.446.400 --- esculin MeSH D03.830.219.446.520 --- 4- ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)

Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.comApplication # 2005/0002865. Diagnostic/therapeutic agents - Patents.com

... chromonar, ciadox, ciamexon, cianergoline, cianidol, cianopramine, ciapilome, cicaprost, cicarperone, ciclactate, ciclafrine, ...
more infohttp://www.patents.com/us-20050002865.html

Effects of Sevoflurane on Regional Myocardial Blood Flow Distribution  :Quantification with Myocardial Contrast...Effects of Sevoflurane on Regional Myocardial Blood Flow Distribution :Quantification with Myocardial Contrast...

POTENT coronary vasodilators, including adenosine, chromonar, and dipyridamole, have been shown to cause myocardial ischemia ...
more infohttp://anesthesiology.pubs.asahq.org/article.aspx?articleid=1946424

Pharmaceutical products list 46Pharmaceutical products list 46

Chromonar *Chromone *Chrom-O-Red Disclosing Solution Concentrate - Germiphene *Chromosmon *Chromosol Ophta - Sandoz *Chromosorb ...
more infohttps://drugs-about.com/drugs/drugs-46.html

MICRO-RNAS OF THE MIR-15 FAMILY MODULATE CARDIOMYOCYTE SURVIVAL AND     CARDIAC REPAIR - Patent applicationMICRO-RNAS OF THE MIR-15 FAMILY MODULATE CARDIOMYOCYTE SURVIVAL AND CARDIAC REPAIR - Patent application

... chromonar, clobenfurol, clonitrate, dilazep, dipyridamole, droprenilamine, efloxate, erythrityl tetranitrane, etafenone, ...
more infohttp://www.patentsencyclopedia.com/app/20140051745

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