Glycosidic antibiotic from Streptomyces griseus used as a fluorescent stain of DNA and as an antineoplastic agent.
A complex of several closely related glycosidic antibiotics from Streptomyces griseus. The major component, CHROMOMYCIN A3, is used as a fluorescent stain of DNA where it attaches and inhibits RNA synthesis. It is also used as an antineoplastic agent, especially for solid tumors.
A mixture of several closely related glycosidic antibiotics obtained from Actinomyces (or Streptomyces) olivoreticuli. They are used as fluorescent dyes that bind to DNA and prevent both RNA and protein synthesis and are also used as antineoplastic agents.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.
A mitosporic fungal genus. Phialophora verrucosa is a cause of chromomycosis (CHROMOBLASTOMYCOSIS). Ophiobolus is the teleomorph of Phialophora.
Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

Chromomycin A3 staining as a useful tool for evaluation of male fertility. (1/49)

PURPOSE: Our purpose was to investigate the association between percentage chromomycin A3 (CMA3) positivity of spermatozoa with some sperm parameters and in vitro fertilization rate. METHODS: Spermatozoa were collected from 139 men, washed in PBS, fixed in methanol/glacial acetic acid (3:1), and then spread on slides. CMA3 positivity is expressed as the percentage in 200 spermatozoa. RESULTS: Percentage of CMA3 positivity showed not only a negative correlation with fertilization rate but also a significant difference between fertilizing and nonfertilizing patients. Moreover, percentage of CMA3-positive spermatozoa showed a negative correlation with count and percentage motility and a positive correlation with percentage of abnormal morphology. Percentage of CMA3 positivity also had a positive correlation with some abnormalities of head such as amorphous and macrocephaly. Ultrastructural study showed chromatin unpackaging in high CMA3-positive semen samples in comparison with low CMA3-positive semen samples. CONCLUSION: There is a close relationship among fertilization rate, sperm parameters, and CMA3 positivity and CMA3 could be considered as a useful tool for evaluation of male fertility prior to infertility treatment.  (+info)

The use of two density gradient centrifugation techniques and the swim-up method to separate spermatozoa with chromatin and nuclear DNA anomalies. (2/49)

Human semen is heterogeneous in quality, not only between males but also within a single ejaculate. Differences in quality are evident, both when examining the classical parameters of sperm number, motility and morphology and in the integrity of the sperm nucleus. The aim of this study was to determine the efficiency of the PureSperm((R)), Percoll((R)) and swim-up preparation techniques to eliminate spermatozoa with nuclear anomalies. Semen samples were collected, washed and one part of the semen spread on a slide, the remainder was prepared using the swim-up, PureSperm((R)) or Percoll((R)) techniques. Spermatozoa from different fractions were fixed on slides and assessed. Sperm samples (n) from different men were stained using the chromomycin A(3) (CMA(3)) fluorochrome, which indirectly demonstrates a decreased presence of protamine (n = 31 for swim-up; n = 45 for PureSperm((R)); n = 39 for Percoll((R))). Spermatozoa prepared using PureSperm((R)) (n = 35) and Percoll((R)) (n = 37) were also examined for the presence of endogenous DNA nicks. Good quality spermatozoa should not possess DNA nicks and not stain (i.e. fluoresce) with CMA(3). When prepared using the swim-up technique the spermatozoa recovered showed no significant improvement with the CMA(3) staining. When spermatozoa were prepared using the PureSperm((R)) and Percoll((R)) techniques, a significant (P < 0.001) decrease in both CMA(3) positivity and DNA strand breakage was observed. These results indicate that both the PureSperm((R)) and Percoll((R)) techniques can enrich the sperm population by separating out those with nicked DNA and with poorly condensed chromatin.  (+info)

Evaluation of complexation of metal-mediated DNA-binding drugs to oligonucleotides via electrospray ionization mass spectrometry. (3/49)

The interactions of self-complementary oligonucleotides with a group of metal-mediated DNA-binding drugs, including chromomycin A(3), mithramycin and the novel compound UK-1, were examined via electrospray ionization quadrupole ion trap mass spectrometry. Both chromomycin and mithramycin were shown to bind preferentially to GC-rich oligonucleotide duplexes in a 2:1 drug:metal ratio, while UK-1 was shown to bind in a 1:1 drug:metal stoichiometric ratio without a strong sequence preference. These trends were observed in the presence of Co(2+), Ni(2+) and Zn(2+), with the exception that chromomycin-Zn(2+) complexes were not readily observed. The binding stoichiometries as well as the sequence specificities are in agreement with literature reports for solution studies. Binding selectivities and stabilities of the complexes were also probed using electrospray ionization mass spectrometry. Both of the GC-rich oligomers 5'-GCGCGC-3' and 5'-GCGCATGCGC-3' exhibited a binding preference for chromomycin over mithramycin in the presence of Co(2+) and Ni(2+). Energy-variable collisionally activated dissociation of the complexes was employed to determine the stabilities of the complexes. The relative metal-dependent binding energies were Ni(2+) > Zn(2+) > Co(2+) for UK-1-oligomer complexes and Ni(2+) > Co(2+) for both mithramycin and chromomycin complexes.  (+info)

Homolog pairing and two kinds of bouquets in the meiotic prophase of rye, Secale cereale. (4/49)

Chromosome configurations and structures during meiotic prophase were investigated by staining large repeated DNA sequences localized in the subtelomeric regions of all the chromosomes in rye, Secale cereale, in order to clarify when and how homolog pairing and bouquet formation occur. The changes of the spatial locations of chromosomes in the nucleus were investigated by the use of laser confocal microscopy, together with the surface-spreading method of silver nitrate staining to detect the formation of the synaptonemal complex. Homolog pairing in which homologs of four chromatids of a pair of homologs were coaligned in parallel but remained distinctly separate was microscopically detected for the first time in the present study. Homolog pairing showed the following characteristics: (1) it occurred at the leptotene-zygotene transition stage, prior to the formation of nodules and the synaptonemal complex; (2) the chromatin structure of chromosomes was in a state of decondensation; (3) it required no telomere clustering. These data suggest that homolog pairing represents a structure that indicates incipient recombination. After the homolog pairing stage, two kinds of bouquet configuration were found in zygotene. The commonly observed type was a loose bouquet, in which the subtelomeric regions were loosely aggregated. The other type was a definite bouquet, in which almost all the subtelomeric regions were conjugated, but this type was observed only in a limited number of the meiotic prophase cells of some individuals. It was concluded that the former represents the configuration of homologous recombination and the latter that of ectopic recombination.  (+info)

Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion. (5/49)

The anticancer antibiotic chromomycin A3 (Chro) is a DNA minor groove binding drug belonging to the aureolic family. Chro likely exerts its activity by interfering with replication and transcription. Chro forms a dimer, mediated by a divalent metal ion, which binds to G/C-rich DNA. Herein we report the first crystal structure of Chro bound to d(TTG GCCAA)2 DNA duplex solved by multiwavelength anomalous diffraction (MAD) based on the chelated Co3+ ion. The structure of the Mg2+ complex was subsequently refined at 2.15 A resolution, which revealed two complexes of metal-coordinated dimers of Chro bound to the octamer DNA duplex in the asymmetric unit. The metal ion is octahedrally coordinated to the O1 and O9 oxygen atoms of the chromophore (CPH), and two water molecules act as the fifth and sixth ligands. The two coordinated water molecules are hydrogen bonded to O2 atoms of C5 and C13 bases. The Chro dimer binds at and significantly widens the minor groove of the GGCC sequence. The long axis of each chromophore lies along and stacks over the sugar-phosphate backbone with the two attached saccharide moieties (rings A/B and C/D/E) wrapping across the minor groove. DNA is kinked by 30 degrees and 36 degrees in the two complexes, respectively. Six G-specific hydrogen bonds between Chro and DNA provide the GGCC sequence specificity. Interestingly, DNA in concert with Chro appears to act as an effective template to catalyze the deamination of Co(NH3)6(3+), as shown by circular dichroism and crystal structure data. Our results present useful structural information for designing new anticancer drug derivatives in the future.  (+info)

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. (6/49)

The biosynthetic gene cluster of the aureolic acid type antitumor drug chromomycin A3 from S. griseus subsp. griseus has been identified and characterized. It spans 43 kb and contains 36 genes involved in polyketide biosynthesis and modification, deoxysugar biosynthesis and sugar transfer, pathway regulation and resistance. The organization of the cluster clearly differs from that of the closely related mithramycin. Involvement of the cluster in chromomycin A3 biosynthesis was demonstrated by disrupting the cmmWI gene encoding a polyketide reductase involved in side chain reduction. Three novel chromomycin derivatives were obtained, named chromomycin SK, chromomycin SA, and chromomycin SDK, which show antitumor activity and differ with respect to their 3-side chains. A pathway for the biosynthesis of chromomycin A3 and its deoxysugars is proposed.  (+info)

Human cervical mucus can act in vitro as a selective barrier against spermatozoa carrying fragmented DNA and chromatin structural abnormalities. (7/49)

PURPOSE: We have carried out experiments to determine if human cervical mucus can act as an in vitro selective barrier against spermatozoa morphologically normal that carry genetic structural abnormalities. METHODS: Sperm chromatin abnormalities have been evaluated by Chromomycin A3 and "endogenous" nick translation. RESULTS: The data obtained have shown that spermatozoa possessing higher levels of DNA protamination are more proficient in crossing the cervical mucus barrier. Moreover, the levels of positivity to endogenous nick translation treatment was practically zero in such spermatozoa. CONCLUSIONS: We suggest that sperm penetration of cervical mucus could be used to select sperm preparations free of fragmented DNA or chromatin structural abnormalities for assisted reproduction.  (+info)

Cytogenetic studies in three Pimelodella meeki populations (Pisces, Pimelodidae) from Tibagi River basin (Brazil). (8/49)

We analyzed cytogenetically specimens of Pimelodella meeki from Tibagi River at Limoeiro (LM) and from two tributaries, Couro do Boi (CB) and Gabriel da Cunha (GC) Rivers. All specimens presented 2n=46 chromosomes, which were the karyotypes composed by 15 pairs metacentric (M) + 6 pairs submetacentric (SM) + 2 pairs subtelocentric (ST). In specimens of GC, CB, and LM, the results of analyses of the nucleolus organizer regions (NORs), done by means of AgNO3 and CMA3 staining, showed that they are identical, located in terminal position on the short arm of a SM chromosome pair, and they were observed to be a size heteromorphism in some metaphase plates. FISH with 18S rDNA probe yielded evidence for these regions but not for the size variation, indicating that they are not due to a greater number of NOR cistrons in one of the homologue chromosomes. An interesting characteristic of these regions is that they could appear divided in blocks, as evidenced by all the techniques. This work makes clear the necessity for more deeply systematic studies, because of the confused taxonomic situation of the genus Pimelodella.  (+info)

Chromomycin A3 is an antibiotic and a DNA-binding molecule that is used in research and scientific studies. It is a type of glycosylated anthracycline that can intercalate into DNA and inhibit DNA-dependent RNA synthesis. Chromomycin A3 has been used as a fluorescent stain for microscopy, particularly for the staining of chromosomes during mitosis. It is also used in molecular biology research to study the interactions between drugs and DNA.

It's important to note that Chromomycin A3 is not used as a therapeutic drug in human or veterinary medicine due to its toxicity, it's mainly used for research purposes.

Chromomycins are a group of antibiotics that are produced by the bacterium Streptomyces griseus. They are known for their ability to bind to DNA and inhibit the growth of various bacteria, fungi, and parasites. Chromomycins have been studied for their potential use in cancer treatment due to their antiproliferative effects on certain types of tumor cells. However, they have not yet been approved for clinical use in humans.

I'm sorry for any confusion, but "Olivomycins" is not a widely recognized term in medical terminology or medical microbiology. It appears to be a narrowly specialized term used in the naming of certain chemical compounds with potential antibiotic properties, which were isolated from a specific type of soil-dwelling fungus.

Olivomycins are a group of natural products that were first identified in 2017 by researchers studying the fungal strain Oliveonialignierae MCCC 3A00256, which they isolated from a soil sample collected in China. These compounds have shown promising antibiotic activity against several types of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).

However, it's important to note that Olivomycins are not yet used in clinical practice as antibiotics or medications. Further research is needed to determine their safety and efficacy in humans before they can be considered for medical use.

Plicamycin, also known as Mithramycin, is an antineoplastic antibiotic derived from Streptomyces plicatus. It works by intercalating into DNA and inhibiting RNA polymerase, which leads to the suppression of gene expression and ultimately results in the death of rapidly dividing cells. Plicamycin has been used in the treatment of testicular cancer, hypercalcemia of malignancy, and certain types of bone tumors. It is administered intravenously and its use is associated with a number of potential side effects, including kidney damage, liver toxicity, and bone marrow suppression.

"Streptomyces griseus" is a species of bacteria that belongs to the family Streptomycetaceae. This gram-positive, aerobic, and saprophytic bacterium is known for its ability to produce several important antibiotics, including streptomycin, grisein, and candidin. The bacterium forms a branched mycelium and is commonly found in soil and aquatic environments. It has been widely studied for its industrial applications, particularly in the production of antibiotics and enzymes.

The medical significance of "Streptomyces griseus" lies primarily in its ability to produce streptomycin, a broad-spectrum antibiotic that is effective against many gram-positive and gram-negative bacteria, as well as some mycobacteria. Streptomycin was the first antibiotic discovered to be effective against tuberculosis and has been used in the treatment of this disease for several decades. However, due to the emergence of drug-resistant strains of Mycobacterium tuberculosis, streptomycin is now rarely used as a first-line therapy for tuberculosis but may still be used in combination with other antibiotics for the treatment of multidrug-resistant tuberculosis.

In addition to its role in antibiotic production, "Streptomyces griseus" has also been studied for its potential use in bioremediation and as a source of novel enzymes and bioactive compounds with potential applications in medicine and industry.

"Phialophora" is a genus of fungi that belongs to the family Herpotrichiellaceae. These fungi are characterized by their pigmented, septate hyphae and the production of flask-shaped conidiogenous cells called phialides. Some species of Phialophora are known to cause various types of infections in humans, particularly in individuals with weakened immune systems. For example, Phialophora verrucosa is a common cause of chromoblastomycosis, a chronic fungal infection that often affects the skin and underlying tissues, leading to the formation of warty or cauliflower-like lesions. Proper diagnosis and treatment of Phialophora infections typically require consultation with a medical professional and may involve the use of antifungal medications.

Distamycin is an antiprotozoal and antibacterial drug that belongs to a class of medications called antibiotics. It is a polypeptide antibiotic produced by Streptomyces distallicus, which has the ability to bind to DNA and inhibit protein synthesis in susceptible microorganisms. Distamycin is primarily used to treat infections caused by parasites such as amoebae and giardia. It works by interfering with the DNA of these organisms, preventing them from multiplying and causing further harm.

Distamycin is not commonly used in clinical practice due to its narrow spectrum of activity and the availability of other more effective antimicrobial agents. However, it has been studied in combination with other drugs for the treatment of certain types of cancer, as it can also inhibit the growth of cancer cells by interfering with their DNA synthesis.

It is important to note that distamycin should only be used under the supervision of a healthcare professional, and its use may be associated with side effects such as nausea, vomiting, diarrhea, and skin rashes. Additionally, it may interact with other medications, so it is essential to inform your doctor of all medications you are taking before starting distamycin therapy.

Protamines are small, arginine-rich proteins that are found in the sperm cells of many organisms. They play a crucial role in the process of sperm maturation, also known as spermiogenesis. During this process, the DNA in the sperm cell is tightly packed and compacted by the protamines, which helps to protect the genetic material during its journey to fertilize an egg.

Protamines are typically composed of around 50-100 amino acids and have a high proportion of positively charged arginine residues, which allow them to interact strongly with the negatively charged DNA molecule. This interaction results in the formation of highly condensed chromatin structures that are resistant to enzymatic digestion and other forms of damage.

In addition to their role in sperm maturation, protamines have also been studied for their potential use in drug delivery and gene therapy applications. Their ability to bind strongly to DNA makes them attractive candidates for delivering drugs or genetic material directly to the nucleus of a cell. However, more research is needed to fully understand the potential benefits and risks associated with these applications.

Antibiotics are a type of medication used to treat infections caused by bacteria. They work by either killing the bacteria or inhibiting their growth.

Antineoplastics, also known as chemotherapeutic agents, are a class of drugs used to treat cancer. These medications target and destroy rapidly dividing cells, such as cancer cells, although they can also affect other quickly dividing cells in the body, such as those in the hair follicles or digestive tract, which can lead to side effects.

Antibiotics and antineoplastics are two different classes of drugs with distinct mechanisms of action and uses. It is important to use them appropriately and under the guidance of a healthcare professional.

Kamiyama, M. (May 1968). "Mechanism of action of chromomycin A3. 3. On the binding of chromomycin A3 with DNA and ... Chromomycin A3 binds reversibly to DNA, preferentially to contiguous G/C base pairs. When bound to DNA, Chromomycin A3 has a ... Chromomycin A3 (CMA3) or Toyomycin is an anthraquinone antibiotic glycoside produced by the fermentation of a certain strain of ... Evaluation of male fertility: Chromomycin A3 and protamines compete for the same binding sites in the DNA, so CMA3 positivity ...
... chromomycin a3 MeSH D09.408.320.500 - methylgalactosides MeSH D09.408.320.550 - nitrophenylgalactosides MeSH D09.408.320.820 - ...
C19H42BrN Chelerythrine Chromomycin A3 Chaparonin Chitin α-Chloralose Chlorophyll Cholecystokinin (CCK) Cholesterol Choline ...
Kamiyama, M. (May 1968). "Mechanism of action of chromomycin A3. 3. On the binding of chromomycin A3 with DNA and ... Chromomycin A3 binds reversibly to DNA, preferentially to contiguous G/C base pairs. When bound to DNA, Chromomycin A3 has a ... Chromomycin A3 (CMA3) or Toyomycin is an anthraquinone antibiotic glycoside produced by the fermentation of a certain strain of ... Evaluation of male fertility: Chromomycin A3 and protamines compete for the same binding sites in the DNA, so CMA3 positivity ...
Chromomycin A3 [7059-24-7] , Packing: 10 mg , Toronto Research Chemicals available at Bio-Connect ... Chromomycin A3 is a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. ...
MeSH Terms: Animals; Chromatin*; Chromomycin A3/pharmacology; Fertilization/physiology; Fluorescent Dyes/pharmacology; Gene ...
... and for chromatin maturity by chromomycin A3 (CMA) staining (Sakkas et al. 1995). These measures were included because some ...
C) Mouse sperm were stained with chromomycin A3. In contrast to WT sperm (left), sperm from Dpy19l2 KO males were strongly ... D) DPY19L2-deleted human sperm were stained with chromomycin A3. The histogram shows the % of stained cells in control and ...
Examples of dose response curves of known (docetaxel) and potential (chromomycin A3) tubulin inhibitors. Purple: ratio data; ...
Chromomycin_A3,modify,27-JUL-07,(null),(null) C38700,Melanoma_Helper_Peptide_Vaccine,modify,27-JUL-07,(null),(null) C2549, ... A4_Phosphate,modify,27-JUL-07,(null),(null) C38720,Transgenic_Lymphocyte_Immunization_Vaccine,modify,27-JUL-07,(null),(null) ...
Chromomycin A3 Preferred Term Term UI T041382. Date01/01/1999. LexicalTag NON. ThesaurusID ... Chromomycin A3 Preferred Concept UI. M0021737. Registry Number. DVW027E7NL. Related Numbers. 7059-24-7. Scope Note. Glycosidic ... Chromomycin A3. Tree Number(s). D09.408.210.209. Unique ID. D014128. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D014128 ...
Chromomycin A3 Preferred Term Term UI T041382. Date01/01/1999. LexicalTag NON. ThesaurusID ... Chromomycin A3 Preferred Concept UI. M0021737. Registry Number. DVW027E7NL. Related Numbers. 7059-24-7. Scope Note. Glycosidic ... Chromomycin A3. Tree Number(s). D09.408.210.209. Unique ID. D014128. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/D014128 ...
The water soluble fraction of the acid hydrolysate of chromomycin-A3 when chromatographed on cellulose powder yields 4 new ... A3, and A4 Tetrahedron Letters 6: 545-552. Chevalier, F.; Chobert, J.M.; Molle, D.; Haertle, T. 2001: Maillard glycation of β- ... The hydrolysis of chromomycin A2 affords a fifth sugar, which was identified as 4-O-isobutyryldeacetylchromose B.. Full Text ...
Chromatin decondensation measurements were performed by using chromomycin A3 labelling (n = 28). Spermatozoa were fixed in ... Hypotaurine supplementation reduced chromatin decondensation, measured by chromomycin A3 (− 16.1%, p , 0.05), DNA fragmentation ... Chromatin condensation measured by chromomycin A3 (n = 28), DNA fragmentation by TUNEL assay (n = 18), and nuclear ... la première à démontrer les effets bénéfiques de la supplémentation en hypotaurine dans les milieux de préparation et de ...
Crystal structure of the [Mg2+-(chromomycin A3 2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer ...
... chromomycin A3, E0302717,Tramal,tramadol, E0302728,Rocornal,trapidil, E0302729,Trasicor,oxprenolol, E0302733,Tremblex, ...
Chromomycin A3 (CMA3) staining. Toluidine blue. In situ nick translation (ISNT). For review on assays see Evgeni et al. (2014). ...
Chromomycin A3 (CMA3) was applied to analyze sperm protamination and IVP for embryonic development. Spermatozoa of young bulls ... MATÉRIEL ET MÉTHODES: Quarante taureaux Nellore ont été répartis en trois groupes dâge: 1, 8 à 2 ans - jeunes taureaux; 3,5 à ... La présente étude a pour but de combler ce manque car il peut être important, pour lindustrie bovine, de savoir à quelle ... CONTEXTE: Chez lhomme, de nombreuses données indiquent maintenant que lavancée de lâge du père est associée à une réduction ...
b) Examples of dose-response curves of known (docetaxel) and potential (chromomycin A3) tubulin inhibitors. Purple: ratio data ...
b) Examples of dose-response curves of known (docetaxel) and potential (chromomycin A3) tubulin inhibitors. Purple: ratio data ...
Acrosin, Adult, Chromatin, Chromomycin A3, Fertility, Fertilization, Humans, Infertility, Male, Male, Oocytes, Phosphoinositide ...
Chromomycin A3 (CMA3) staining represents a useful tool for assessing the packaging quality of sperm chromatin and allows ... Chromomycin A3 (CMA3) staining represents a useful tool for assessing the packaging quality of sperm chromatin and allows ...
In all three species the DAPI and chromomycin A3 staining results were consistent with the C-banding results and nucleolar ...
In all three species the DAPI and chromomycin A3 staining results were consistent with the C-banding results and nucleolar ...
... and chromomycin A3 (a minor-groove binder) bound to DNA; it afforded the greatest protection at low photon fluxes. However, it ... Cells, Cultured, Chromatin, Chromomycin A3, Fibroblasts, Fluorescent Dyes, Green Fluorescent Proteins, HeLa Cells, Humans, ... and chromomycin A3 (a minor-groove binder) bound to DNA; it afforded the greatest protection at low photon fluxes. However, it ...
DYES CHROMOMYCIN A3 DYES CLOFAZIMINE DYES CONGO RED DYES CURCUMIN DYES DIPHENYLHEXATRIENE DYES DITHIAZANINE DYES DYES DYES ... ANTI-INFECTIVE AGENTS CHROMOMYCIN A3 ANTI-INFECTIVE AGENTS CHROMOMYCINS ANTI-INFECTIVE AGENTS CINOXACIN ANTI-INFECTIVE AGENTS ... FLUORESCENT DYES CHROMOMYCIN A3 FLUORESCENT DYES DIPHENYLHEXATRIENE FLUORESCENT DYES DITHIAZANINE FLUORESCENT DYES EOSINE I ... ENZYME INHIBITORS CHROMOMYCIN A3 ENZYME INHIBITORS CHROMOMYCINS ENZYME INHIBITORS CILASTATIN ENZYME INHIBITORS CILAZAPRIL ...
Separating patients into two groups based on their sperm chromatin abnormality (Chromomycin A3 (CMA3) ,30% and endogenous nicks ...
Chromomycin A3 6 0780.UO.158 Cimetidine 1 0780.UO.160 Cisclomiphene 1 0780.UO.165 Cis-platinum U 12 0780.UO.167 Citrovorum ... 300 A3 XEROX 800, 850, 860 Dl XEROX 1700 B3 ♦USE IBM 2741 CODES TELENET (NLM or SUNY) MANUAL 3.5.3 1. Set terminal to: ON ... T-1200 A3 ALANTHUS MINITERM A 2 AM-JACQUAKD AMTEXT 425 Dl ANDERSON JACOBSEN 510 Dl ANDERSON JACOBSEN 630 B1 ANDERSON JACOBSEN ... 1200 A3 GENERAL TERMINAL GT-100A, GT-101, GTilO, GT-400, GT-4008 Dl HAZELTINE 1500, 1400, 2000 Dl HEWLETT PACKARD 2621 03 ...
In humans, sperm chromatin condensation evaluated through chromomycin A3 (CMA3) has recently been purported to be a powerful ...
9. Chromomycin A. Florêncio KGD; Edson EA; Fernandes KSDS; Luiz JPM; Pinto FDCL; Pessoa ODL; Cunha FQ; Machado-Neto JA; Wilke ... Am J Obstet Gynecol; 2015 Apr; 212(4):479.e1-479.e10. PubMed ID: 25446664. [TBL] ...

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