Chromogranin B: A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.Chromogranin A: A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.Chromogranins: A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.Secretogranin II: A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.Adrenal Medulla: The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.Cytoplasmic Granules: Condensed areas of cellular material that may be bounded by a membrane.PC12 Cells: A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.Inositol 1,4,5-Trisphosphate Receptors: Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.Pancreatic Hormones: Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Dithiothreitol: A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.

The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules. (1/53)

The disulfide-bonded loop of chromogranin B (CgB), a regulated secretory protein with widespread distribution in neuroendocrine cells, is known to be essential for the sorting of CgB from the trans-Golgi network (TGN) to immature secretory granules. Here we show that this loop, when fused to the constitutively secreted protein alpha1-antitrypsin (AT), is sufficient to direct the fusion protein to secretory granules. Importantly, the sorting efficiency of the AT reporter protein bearing two loops (E2/3-AT-E2/3) is much higher compared with that of AT with a single disulfide-bonded loop. In contrast to endogenous CgB, E2/3-AT-E2/3 does not undergo Ca2+/pH-dependent aggregation in the TGN. Furthermore, the disulfide-bonded loop of CgB mediates membrane binding in the TGN and does so with 5-fold higher efficiency if two loops are present on the reporter protein. The latter finding supports the concept that under physiological conditions, aggregates of CgB are the sorted units of cargo which have multiple loops on their surface leading to high membrane binding and sorting efficiency of CgB in the TGN.  (+info)

Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. (2/53)

Chromogranin A (CgA) and chromogranin B (CgB) are acidic proteins stored in and released from hormone granules in endocrine and neuroendocrine tissue. The chromogranins are postulated to serve as pro-hormones to generate biologically active peptides, which may influence hormonal release and vascular functions or have antibacterial functions. Although N-terminal and C-terminal regions show some species amino acid homology, the chromogranins as a whole display considerable interspecies differences, which prevents their use in comparative studies of biological functions. We present four new radioimmunoassays for the measurement of defined N-terminal regions of CgA and CgB. A new radioimmunoassay for measurement of intact bovine CgA has also been developed. With these assays and two previously published ones, we have compared the cross-reactivity of chromogranins from man, cattle, sheep, goat, pig and horse and compared adrenomedullar content and serum levels of CgA from these species. We have also studied the influence of peptide concentrations and the ionic strength of the mobile phase on molecular weight estimations. Assays with antibodies directed against the N-terminal parts of CgA and CgB showed sufficient interspecies cross-reactivity to allow comparative quantification of the circulating levels in man, cattle, sheep, goat, pig and horse. Assays measuring the intact human or bovine CgA were not suitable for comparative purposes in samples from sheep, goat, pig and horse. Molecular interactions between vasostatin immunoreactive material and intact bovine CgA were demonstrated in gel permeation studies, suggesting that conclusions about the degree of N-terminal processing from elution profiles should be made with caution. Reliable interspecies comparison of chromogranins is difficult, but measurements with region-specific assays may be helpful to study concentrations of chromogranins and chromogranin-related peptides.  (+info)

Identification and characterization of novel chromogranin B-derived peptides from porcine chromaffin granules by liquid chromatography/electrospray tandem MS. (3/53)

Chromogranin B (CgB) is a regulated secretory protein that is stored in endocrine and neuroendocrine cells. It can be processed proteolytically to small peptide fragments. In the present study three proteolytic products of porcine CgB were obtained after size-exclusion, immunoaffinity, and reversed-phase chromatography, and then identified by electrospray tandem MS. One novel peptide was identified as S586-R602 (SR-17) and is phosphorylated at one or two serine residues. Another novel peptide H603-Q636 (HQ-34), with molecular mass 3815.56 Da, was found to be oxidized at the methionine residue. In addition, a secretolytin-like peptide fragment (KR-11), which is two amino acids shorter than the bovine secretolytin, was found. This is the first report that the C-terminal region of CgB, the homologue of human CCB, is proteolytically processed further into three small peptide fragments.  (+info)

Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides. (4/53)

Chromogranin B (CgB) is a member of the granin family of neuroendocrine secretory proteins, which has been proposed to play a role in secretory granule biogenesis and as a precursor to bioactive peptides. The cloning of CgB in a phylogenetically distant vertebrate, the frog Rana ridibunda, reveals a modest overall homology (35-40%) with mammalian CgB. However, the sequences of the N- and C-terminal regions are more highly conserved (57-65% amino acid identity) and may give rise to novel regulatory peptides. In frog, intense expression of CgB mRNA was observed in particular structures of the brain and in the distal lobe of the pituitary.  (+info)

Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control. (5/53)

Chromogranins A (CGA) and B (CGB) are two major Ca(2+) storage proteins of the secretory granules of neuroendocrine cells. Nevertheless, we found in the present study that CGB was also localized in the nucleus. In immunogold electron microscopy using bovine adrenal medullary chromaffin cells, it was found that the number of CGB-labeled gold particles localized per microm(2) of the nucleus was equivalent to 20% that of CGB-labeled gold particles localized per microm(2) of the secretory granules. Considering that CGB is estimated to exist in the 0.1-0.2-mm range in the secretory granules of bovine chromaffin cells, 20% of these amounts to 20-40 microm. In addition, transfection of CGA and CGB into nonneuroendocrine COS-7 and NIH3T3 cells repeatedly indicated the nuclear localization of CGB in addition to its usual localization in the cytoplasm. Moreover, immunoblot and immunogold electron microscopy analyses of neuroendocrine PC12 cells also showed the existence of endogenous CGB in both the cytosol and the nucleus. Nuclear routing of CGB did not appear to depend entirely upon the nuclear localization signal as some of the nuclear localization signal mutant CGB were still targeted to the nucleus. In gene array assay, CGB was shown to either induce or suppress transcription of many genes including those of transcription factors. Of these we have analyzed eight genes, four induced (zinc finger protein, MEF2C, hCRP2, abLIM) and four suppressed (hcKrox, T3-receptor, troponin C, integrin) using the quantitative reverse transcription-PCR method and spectrophotometry to determine the transcription levels of each mRNA. CGB was shown to increase the transcription of zinc finger protein, MEF2C, hCRP2, and abLIM by 2.5-5-fold while suppressing that of hcKrox, T3-receptor, troponin C, and integrin by 60-75%. Given that MEF2C and hcKrox genes are transcription factors, these results pointed to the transcription control role of CGB in the nucleus.  (+info)

Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. (6/53)

Chromogranin A (CGA) and chromogranin B (CGB) are acidic proteins stored in secretory organelles of endocrine cells and neurons. In addition to their roles as helper proteins in the packaging of peptides, they may serve as prohormones to generate biologically active peptides such as vasostatin-1 and secretolytin. These molecules derived from CGA and CGB, respectively, possess antimicrobial properties. The present study demonstrates that plasmatic levels of both vasostatin-1 and secretolytin increase during surgery in patients undergoing cardiopulmonary bypass (CPB). Vasostatin-1 and secretolytin, initially present in plasma at low levels, are released just after skin incision. Consequently, they can be added to enkelytin, an antibacterial peptide derived from proenkephalin A, for the panoply of components acting as a first protective barrier against hypothetical invasion of pathogens, which may occur during surgery. CGA and CGB, more commonly viewed as markers for endocrine and neuronal cells, were also found to have an immune origin. RNA messengers coding for CGB were amplified by reverse transcription-polymerase chain reaction in human monocytes, and immunocytochemical analysis by confocal microscopy revealed the presence of CGA or CGB or both in monocytes and neutrophils. A combination of techniques including confocal microscopic analysis, mass spectrometry measurement, and antibacterial tests allowed for the identification of the positive role of interleukin 6 (IL-6) in the secretolytin release from monocytes in vitro. Because IL-6 release is known to be strongly enhanced during CPB, we suggest a possible relationship between IL-6 and the increased level of secretolytin in patients undergoing CPB.  (+info)

Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. (7/53)

The two major proteins of secretory granules of secretory cells, chromogranins A (CGA) and B (CGB), have previously been proposed to play key roles in secretory granule biogenesis. Recently, CGA was reported to play an on/off switch role for secretory granule biogenesis. In the present study we found CGB being more effective than CGA in inducing secretory granule formation in non-neuroendocrine NIH3T3 and COS-7 cells. The mean number of dense core granules formed/cell of CGA-transfected NIH3T3 cells was 2.51, whereas that of CGB-transfected cells was 4.02, indicating the formation of 60% more granules in the CGB-transfected cells. Similarly, there were 55% more dense core granules formed in the CGB-transfected COS-7 cells than in the CGA-transfected cells. Moreover, transfection of CGA- and CGB-short interfering RNA (siRNA) into neuroendocrine PC12 cells not only decreased the amount of CGA and CGB expressed but also reduced the number of secretory granules by 41 and 78%, respectively, further suggesting the importance of CGB expression in secretory granule formation.  (+info)

A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. (8/53)

Chromogranins A and B (CGA and CGB) are high capacity, low affinity calcium (Ca2+) storage proteins found in many cell types most often associated with secretory granules of secretory cells but also with the endoplasmic reticulum (ER) lumen of these cells. Both CGA and CGB associate with inositol 1,4,5-trisphosphate receptor (InsP3R) in a pH-dependent manner. At an intraluminal pH of 5.5, as found in secretory vesicles, both CGA and CGB bind to the InsP3R. When the intraluminal pH is 7.5, as found in the ER, CGA totally dissociates from InsP3R, whereas CGB only partially dissociates. To investigate the functional consequences of the interaction between the InsP3R and CGB monomers or CGA/CGB heteromers, purified mouse InsP3R type I were fused to planar lipid bilayers and activated by 2 microM InsP3. In the presence of luminal CGB monomers or CGA/CGB heteromers the InsP3R/Ca2+ channel open probability and mean open time increased significantly. The channel activity remained elevated when the pH was changed to 7.5, a reflection of CGB binding to the InsP3R even at pH 7.5. These results suggest that CGB may play an important modulatory role in the control of Ca2+ release from the ER. Furthermore, the difference in the ability of CGA and CGB to regulate the InsP3R/Ca2+ channel and the variability of CGA/CGB ratios could influence the pattern of InsP3-mediated Ca2+ release.  (+info)

*SCG5

Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med. 348 (12): 1134-49. doi: ... "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol. 3 (1): 38-45. doi:10.1097 ...

*SCG3

Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... "Entrez Gene: SCG3 secretogranin III". Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) ... "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of ...

*Granin

Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of ...

*SCG2

2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human ... Chromogranin Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... 2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1-3): 13-21. doi:10.1016/j.regpep.2008.07. ...

*Homeostasis

"The chromogranins and counter-regulatory hormones: do they make homeostatic sense?". Journal of Physiology. 517 (3): 643-649. ...

*Carcinoid syndrome

Chromogranin A and platelets serotonin are increased.[clarification needed] Tumour localization may be extremely difficult.[ ... Nobels FR, Kwekkeboom DJ, Bouillon R, Lamberts SW (1998). "Chromogranin A: its clinical value as marker of neuroendocrine ... Markers of the condition such as chromogranin-A are imperfect indicators of disease progression. Prognosis varies from ...

*Pheochromocytoma

Chromogranin A is elevated in case of pheochromocytoma. Micrograph of pheochromocytoma. Micrograph of pheochromocytoma. ...

*Ceruminous adenoma

The cells are negative with chromogranin, synaptophysin and CK20. The major diagnosis from which to separate ceruminous adenoma ...

*Saliva testing

"Chromogranin A detection in saliva of type 2 diabetes patients". Bosn J Basic Med Sci. 10: 2-8. PMID 20192923. CS1 maint: ... chromogranin A) was over-expressed in 100% of diabetic patients when compared to controls. In 2010 Qvarnstrom, et al., ...

*Secretoneurin

Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is also called ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...

*Neuroendocrine tumor

Aside from the hormones of secretory tumors, the most important markers are: chromogranin A (CgA), present in 99% of metastatic ... Neuroendocrine secretory protein-55, a member of the chromogranin family, is seen in pancreatic endocrine tumors but not ... Widely used neuroendocrine tissue markers are various chromogranins, synaptophysin and PGP9.5. Neuron-specific enolase (NSE) is ... chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated. Functional tumors are ...

*Lung cancer

SCLC derived from neuroendocrine cells may express CD56, neural cell adhesion molecule, synaptophysin or chromogranin. Lung ...

*Péptido YY, a enciclopedia libre

1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells ...

*5-Hydroxytryptophan

"Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5- ...

*B3GAT1

Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal ... conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin ...

*Mepartricin

permanent dead link] Fan S, Hao ZY, Zhang L, Chen XG, Zhou J, Zang YF, Tai S, Liang CZ (2014). "Increased chromogranin A and ...

*Xenin

... is a peptide hormone produced by a subpopulation of chromogranin A-positive endocrine cells in the mucous membrane of the ...

*Synaptophysin

Diagnostically, it is often used in combination with chromogranin A. List of human genes Synaptophysin has been shown to ...

*Molecular diagnostics

"Selective Localization of the Parathyroid Secretory Protein-I/Adrenal Medulla Chromogranin a Protein Family in a Wide Variety ...

*Zollinger-Ellison syndrome

An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...

*Paraganglioma

With immunohistochemistry, the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron ...

*Neuroendocrine differentiation

Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely ... chromogranin A (CgA), synaptophysin and neuron-specific enolase (NSE) (three proteins that are used as markers for ... chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or ...

*CHGB

... may refer to: CHGB-FM, a radio station (97.7 FM) licensed to Wasaga Beach, Ontario, Canada Chromogranin B, a protein ...

*Neuroendocrine cell

... chromogranin A, gastrin-releasing peptide (GRP), and cholecystokinin. These cells can be the source of several types of lung ...

*Multiple endocrine neoplasia type 1

Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's ...

*Papillary tumors of the pineal region

Chromogranin → - NSE (neuron-specific enolase) → ++ NFP (neurofilament protein) → - CD56/N-CAM (neural cell adhesion molecule ...
Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp ...
Neuroendocrine tumours (NETs) are rare tumours that originate from neuroendocrine cells and their incidence has increased for the last 20 decades; partly because of advances in diagnostic tools, which have improved detection rates. Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. As a result, we hypothesised that plasma CgB concentration is a more accurate and reliable prognostic indicator in NET patients. Data from 121 NET patients were collected retrospectively and submitted to statistical analyses. In univariate survival analysis, circulating CgB levels were associated with a significantly poorer survival time than CgA. In addition, multivariate analysis was performed by considering other prognostic ...
CHGB - CHGB (Myc-DDK-tagged)-Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company.
Complete information for CHGB gene (Protein Coding), Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. TFH cells produce high amounts of dopamine and release it upon cognate interaction with B cells. Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. Mathematical modelling suggests that faster dopamine-induced T-B-cell interactions increase total germinal centre output and accelerate
CHGB Fragment MS Protein Standard, is a protein fragment containing a 50-150 amino acid sequence identical to part of a human CHGB protein target. The fragment MS Protein Standard represents a new category of using heavy isotope labeled (15N, 13C) Lysine and Arginine residues resulting in more than 99% isotope incorporation, as internal MS standards offering distinct advantages to existing products for relative and absolute quantification.
Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension Academic Article ...
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. Unlike neuroendocrine tissues, pancreatic islets of these animals lacked compensatory changes in other granins and were therefore analyzed in detail. Stimulated secretion of insulin, glucagon and somatostatin was reduced in CgB-ko islets, in parallel with somewhat impaired glucose clearance and reduced insulin release, but normal insulin sensitivity in vivo. CgB-ko islets lacked specifically the rapid initial phase of stimulated secretion, had elevated basal insulin release, and stored and released twice as much proinsulin as wildtype (wt) islets. Stimulated release of
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
a proportion of human TFH [follicular helper T] cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. TFH cells produce high amounts of dopamine and release it upon cognate interaction with B cells ,,. ,, faster dopamine-induced T-B-cell interactions increase total germinal centre output and accelerate it by days ,,. Ilenia Papa, David Saliba, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature 547, 318-323 (July 20, 2017) doi: 10.1038/nature23013. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23013.html. Kate Prestt. Discovery of brain-like activity in immune system promises better disease treatments. July 13, 2017. http://www.anu.edu.au/news/all-news/discovery-of-brain-like-activity-in-immune-system-promises-better-disease-treatments. ...
Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II.
A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary tree including pancreatic duct, with periampullary 30 mm mass lesion projecting into lumen of duodenum. Enlarged nodes were seen around the superior mesenteric artery. This was confirmed on MRI liver. Fasting gut hormones were normal except for a mildly elevated somatostatin level. Chromogranin A was elevated at 78 pmol/L with normal chromogranin B. Duodenoscopy and biopsy showed possible tubovillous adenoma with ...
Shop Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein ELISA Kit, Recombinant Protein and Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Blast transformation of rabbit B-derived lymphocytes by a mitogen extracted from Nocardia.: Nocardia water soluble mitogen (NWSM) is known to stimulate mouse an
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion Academic Article ...
Mouse monoclonal antibody raised against full length recombinant human CHGA. Recombinant protein corresponding to full length human CHGA. (MAB14233) - Products - Abnova
Excessive activation of the hypothalamic pituitary adrenal (HPA) axis has been associated with numerous diseases, including depression, and the tricyclic antidepressant imipramine has been shown to suppress activity of the HPA axis. Central hypothalamic control of the HPA axis is complex and involves a number of neuropeptides released from multiple hypothalamic subnuclei. The present study was therefore designed to determine the effects of imipramine administration on the mouse hypothalamus using a peptidomics approach. Among the factors found to be downregulated after acute (one day) or chronic (21 days) imipramine administration were peptides derived from secretogranin 1 (chromogranin B) as well as peptides derived from cerebellin precursors. In contrast, peptides SRIF-14 and SRIF-28 (1-11) derived from somatostatin (SRIF, somatotropin release inhibiting factor) were significantly upregulated by imipramine in the hypothalamus. Because diminished SRIF levels have long been known to occur in ...
The possibility of differentiating between chromaffin vesicles with different catecholamine contents was tested by studying the distribution of rabbit adrenal dopamine β-hydroxylase (EC 1.14.21) and catecholamines, and the buoyant densities of the catecholamine storage vesicles after isopycnic centrifugation of crude storage vesicle fractions in sucrose density gradients. Catecholamine storage vesicles were prepared from adrenal glands of untreated rabbits, rabbits which had received chlorisondamine chloride (10/kg intraperitoneally) to block ganglionic transmission, and rabbits which had received both chlorisondamine chloride and reserpine (1 mg kg). Adrenal glands were examined 1 day after treatmenmt with chlorisondamine and 1 and 8 days after combined treatment with chlorisondamine and reserpine. Intact storage vesicles obtained from glands of untreated animals had a specific gravity of 1.27, while the membranes obtained from vesicles lysed in distilled water had a specific gravity of 1.12. ...
Carcinoid tumors are rare (2.5 to 5.0 cases per 100,000 of the population per year), slow-growing neuroendocrine malignancies with significant potential to produce hepatic metastases and release excessive amounts of vasoactive amines into the systemic circulation (1). As a consequence, up to 15% of patients may develop carcinoid syndrome, with cutaneous flushing, gastrointestinal hypermotility, and cardiac involvement. Cardiac manifestations, also known as carcinoid heart disease (CaHD), are caused by endocardial deposition of pearly fibrotic plaques (notable for absence of elastic fibers) that generally extend to the right-sided valves, leading to multiple patterns of severe valve dysfunction. Plaque formation causes annular constriction, leaflet thickening, and fusion of the subvalvular apparatus. Marked degeneration of the leaflet architecture leads to severe retraction and noncoaptation of the valve, which remains fixed in a semiopen position (2). In this setting, valve replacement is the ...
Though most types of thyroid cancer are cured by surgery and adjuvant radio- iodine therapy and TSH suppression, patients with radio-iodine refractory thyroid carcinoma as well as with medullary thyroid carcinoma, a neuroendocrine malignancy that does not express iodine transporter, are difficult to treat because of the lack of effective systemic treatment. Therefore, there is an urgent need of novel therapeutic measures for these patients. Thyroid cancer is frequently associated to the oncogenic conversion of protein kinases such as RET (medullary thyroid cancer) and BRAF (papillary and undifferentiated thyroid cancer). Therefore, protein kinase small molecule inhibitors (PKI) have been considered as promising novel agents for the treatment of thyroid carcinoma. Compounds that revealed good RET and BRAF activity both in clinical (vandetanib for RET) and in pre-clinical (vemurafenib for BRAF) settings have been identified. Recently, vandetanib was approved for patients with medullary thyroid ...
The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. Although the precise function of the chromogranins remains elusive, knowledge of their structure, distribution, and potential intracellular and extracellular roles, especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. Thus, measurement of its circulating concentration by radioimmunoassay may be a useful probe of exocytotic sympathoadrenal activity in humans, under both physiological and pathological conditions. Here, we explore the storage, structure, and function of chromogranin A, and parameters that influence its circulating levels. We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. ...
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TY - JOUR. T1 - TRANSPORT AND TURNOVER OF DOPAMINE‐β‐HYDROXYLASE (EC 1.14.2.1) IN SYMPATHETIC NERVES OF THE RAT. AU - Brimijoin, S.. PY - 1972/9. Y1 - 1972/9. N2 - Axoplasmic transport of dopamine‐β‐hydroxylase (DBH), a marker enzyme for catecholamine storage vesicles, was studied in sympathetic nerves of the rat. At 24 h after ligation of the sciatic nerve, there was a marked accumulation of DBH activity in the first 3 mm proximal to the ligature. Immediately distal to the ligature, a slight accumulation took place. Accumulation proximal to the ligature was a linear function of time for at least 6 h; the velocity of transport was calculated as 4.6 mm/h. Local application of 1 ·l of 0.1 M colchicine, caused a rapid increase in DBH activity in superior cervical ganglia. This increase remained linear for 22 h and its rate indicated a turnover time of 12 h for DBH in these ganglia. After application of colchicine to the ganglia, there was a decrease in DBH activity in the submaxillary ...
Secretory granules are specialized intracellular organelles that serve as a storage pool for selected secretory products. The exocytosis of secretory granules is markedly amplified under physiologically stimulated conditions. While granules have been recognized as post-Golgi carriers for almost 40 years, the molecular mechanisms involved in their formation from the trans-Golgi network are only beginning to be defined. This review summarizes and evaluates current information about how secretory proteins are thought to be sorted for the regulated secretory pathway and how these activities are positioned with respect to other post-Golgi sorting events that must occur in parallel. In the first half of the review, the emerging role of immature secretory granules in protein sorting is highlighted. The second half of the review summarizes what is known about the composition of granule membranes. The numerous similarities and relatively limited differences identified between granule membranes and other ...
Compare Secretogranin III ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Complete information for CHGA gene (Protein Coding), Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
C-terminal PHD zinc-finger domain capable of binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional ...
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008 ...
The structure of the gene encoding bovine chromogranin-A has been determined by characterization of two isolated genomic clones. Chromogranin-A is encoded by eight exons, which organize the coding region into several distinct structural and functional domains. Exons 1-5 represent the highly conserved signal peptide and N-terminal domain, which are separated into regions corresponding to the signal peptide, N-terminal sequence, disulfide-bonded loop, and remainder of the conserved N-terminal domain. Exon 6 represents the variable domain and encodes a region that is identical to the novel chromogranin-A-derived peptide chromostatin. Exon 7 encodes the biologically active peptide pancreastatin as well as most of the conserved C-terminal domain, with the remainder found on exon 8. The mRNA sequence obtained from the gene contains five nucleotide differences from the consensus sequence of four reported bovine chromogranin-A cDNA clones. Two of the differences in the gene result in two amino acid changes in
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Patient preparation: Patient must be fasting 10-12 hours prior to collection of specimen. Patient should not be on any medications that may influence Insulin levels, if possible, for at least 48 hours prior to collection. Specimen Type: SST Serum Container/Tube: Serum gel Submission Container/Tube: Plastic vial Specimen Volume: 2 mL Collection Instructions: Draw blood in a serum gel tube(s). Spin down and send 2 mL of serum frozen in a plastic vial.
Chemicals, Active / Peptides - Looking for an AHA from a supplier you can trust? Youve come to the right place. Grouped by individual categories, below youll find a comprehensive listing of companies to choose from, including those spotlighted at the top of each category.
Expression of CHGA () in adrenal gland tissue. Antibody staining with HPA017369, CAB000023, CAB040544, CAB055506 and CAB058688 in immunohistochemistry.
BHC Connect is an online collaborative environment intended to help our 14 hubs organize and interact with one another as well as their communities.

Chromogranin A: Reference Range, Interpretation, Collection and PanelsChromogranin A: Reference Range, Interpretation, Collection and Panels

It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. ... Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the ... It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. Chromogranin A contains ... encoded search term (Chromogranin%20A) and Chromogranin A What to Read Next on Medscape. Medscape Consult. ...
more infohttps://emedicine.medscape.com/article/2114314-overview

Chromogranin A. Storage and release in hypertension. | HypertensionChromogranin A. Storage and release in hypertension. | Hypertension

Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer, D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines ...
more infohttp://hyper.ahajournals.org/content/15/3/237

Evaluation of psychosomatic stress in children by measuring salivary chromogranin A.  - PubMed - NCBIEvaluation of psychosomatic stress in children by measuring salivary chromogranin A. - PubMed - NCBI

Evaluation of psychosomatic stress in children by measuring salivary chromogranin A.. Lee T1, Shimizu T, Iijima M, Obinata K, ... To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16882565?dopt=Abstract

Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | CirculationCatecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation

Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J Biol Chem. 2003; 278 ... Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell. 2001; 106: 499-509. ... Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005; 115: 1942-1952 ... A panel of 11 region-specific radioimmunoassays for measurements of human chromogranin A. Regul Pept. 2004; 117: 219-227. ...
more infohttp://circ.ahajournals.org/content/115/17/2271

Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific...Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific...

Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific ... Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. It has a general ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11257446?dopt=Abstract

Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours? | SFEBES2015Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours? | SFEBES2015

Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been ... This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by ... Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours?. Nipuni E Wanniachchi Wanigasekara, Paul Bech & ... Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were ...
more infohttps://www.endocrine-abstracts.org/ea/0038/ea0038P160

Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, IF,...Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, IF,...

Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB ... AH11074: Chromogranin A / CHGA (Neuroendocrine Marker) Antibody. AH11075: Chromogranin A / CHGA (Neuroendocrine Marker) ... Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide is for research use only and not for use in ... Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43 ...
more infohttp://www.abgent.com/products/AH10256-Chromogranin-A-Antibody-Clone-LK2H10--PHE5--CGA414

Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide -  Mouse Monoclonal Antibody [Clone SPM553 ] IHC...Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone SPM553 ] IHC...

Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone SPM553 ] ... AH11074: Chromogranin A / CHGA (Neuroendocrine Marker) Antibody. AH11075: Chromogranin A / CHGA (Neuroendocrine Marker) ... Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide is for research use only and not for use in ... Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43 ...
more infohttp://www.abgent.com/products/AH10405-Chromogranin-A--CHGA-Neuroendocrine-Marker-Antibody-Without-BSA-and-Azide

CHGB Gene - GeneCards | SCG1 Protein | SCG1 AntibodyCHGB Gene - GeneCards | SCG1 Protein | SCG1 Antibody

Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... chromogranin B (catecholamine and norepenephrine secretory protein) *CHGB. UniProtKB/Swiss-Prot Function: Secretogranin-1 is a ... Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CHGB

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. | PassportGlycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. | Passport

Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information ... Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. ... Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis.. ...
more infohttps://passport.as.uky.edu/glycosylated-chromogranin-heart-failure-implications-processing-and-cardiomyocyte-calcium

Correlation between age and Chromogranin A determination in prostate diseases | IRIS Università degli Studi di PerugiaCorrelation between age and Chromogranin A determination in prostate diseases | IRIS Università degli Studi di Perugia

ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to ... ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to ...
more infohttps://research.unipg.it/handle/11391/923474

CHGB - Secretogranin-1 precursor - Homo sapiens (Human) - CHGB gene & proteinCHGB - Secretogranin-1 precursor - Homo sapiens (Human) - CHGB gene & protein

"The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.". ...
more infohttp://www.uniprot.org/uniprot/P05060

Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated...Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated...

Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated ...
more infohttp://vivo.med.cornell.edu/display/pubid53949122279

PLOS ONE: accelerating the publication of peer-reviewed sciencePLOS ONE: accelerating the publication of peer-reviewed science

Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. ... Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB ... Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice. Obermüller S, Calegari F, King A, Lindqvist A, ... Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice. PLOS ONE 5(1): e8936. https://doi.org/10.1371/journal. ...
more infohttp://journals.plos.org/plosone/article/citation?id=10.1371/journal.pone.0008936

OriGene - CHGB (NM 001819) Human ORF cDNA CloneOriGene - CHGB (NM 001819) Human ORF cDNA Clone

Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company. ... Chgb (untagged) - Mouse chromogranin B (Chgb), (10ug). $190. Next day. MR209967. Chgb (Myc-DDK-tagged) - Mouse chromogranin B ( ... CHGB (GFP-tagged) - Human chromogranin B (secretogranin 1) (CHGB). pCMV6-AC-GFP. pLenti-C-Myc-DDK. pLenti-C-mGFP. $610. In ... Chgb (GFP-tagged) - Mouse chromogranin B (Chgb). $920. 3 weeks. MR209967L1. Lenti ORF clone of Chgb (Myc-DDK-tagged) - Mouse ...
more infohttp://www.origene.com/orf_clone/trueclone/NM_001819/RC201744/CHGB.aspx

CHGA monoclonal antibody, clone CHGA/777 - (MAB14233) - Products - AbnovaCHGA monoclonal antibody, clone CHGA/777 - (MAB14233) - Products - Abnova

betagranin (N-terminal fragment of chromogranin A),chromogranin A,parathyroid secretory protein 1 ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=MAB14233

CHGB Fragment MS Protein Standard - Creative ProteomicsCHGB Fragment MS Protein Standard - Creative Proteomics

Chromogranin-B, Secretogranin I. Uniprot ID. P05060. Protein Name. Secretogranin-1. Description. CHGB Fragment MS Protein ...
more infohttps://www.creative-proteomics.com/product/detail-cpilf22647_11356.htm

RefEx - Search ResultRefEx - Search Result

Pituitary secretory protein I, CgA, Chromogranin A precursor, SP-I, CGA, chromogranin A (CgA), CHGA, chromogranin A ( ...
more infohttp://refex.dbcls.jp/genelist.php?lang=en&db=human&roku_valid=1&rk%5B%5D=35&order_key=score&pageID=2

flashontrack: # s-pnei: brain-like activities; syntesis and release of dopamine by T-cellsflashontrack: # s-pnei: brain-like activities; syntesis and release of dopamine by T-cells

a proportion of human TFH [follicular helper T] cells contain dense-core granules marked by chromogranin B, which are normally ...
more infohttp://flashontrack.blogspot.it/2017/07/s-pnei-brain-like-activities-syntesis.html

TFH-derived dopamine accelerates productive synapses in germinal centres. - The Kennedy Institute of RheumatologyTFH-derived dopamine accelerates productive synapses in germinal centres. - The Kennedy Institute of Rheumatology

... which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. ... Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally ... Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally ... which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. ...
more infohttps://www.kennedy.ox.ac.uk/publications/708069

Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic...Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic...

Chromogranin B * Hypertension * Promoter Regions, Genetic abstract * The common CHGB promoter variants A-296C and A-261T, and ...
more infohttp://vivo.med.cornell.edu/display/pubid77949884304

Chromogranin A | ALZFORUMChromogranin A | ALZFORUM

If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
more infohttps://www.alzforum.org/antibodies/chromogranin-24

Chromogranin A | ALZFORUMChromogranin A | ALZFORUM

If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
more infohttps://www.alzforum.org/antibodies/chromogranin-0

Chromogranin A | LabCorpChromogranin A | LabCorp

The level of chromogranin A in the blood is normally low. A person with no signs or symptoms and a normal level of CgA is ... The chromogranin A (CgA) test is used as a tumor marker. It may be ordered in combination with a 5-HIAA test to help diagnose ... Should everyone have a chromogranin A test?. No. This test is usually ordered to help diagnose and monitor a carcinoid or other ... Chromogranin A can also be increased in people who take proton pump inhibitors (PPIs), which are drugs that reduce the amount ...
more infohttps://www.labcorp.com/help/patient-test-info/chromogranin-a

Chromogranin A/B/C (IPR001990) | InterPro | EMBL-EBIChromogranin A/B/C (IPR001990) | InterPro | EMBL-EBI

Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.. *Secretogranin 2 (chromogranin C): A sulfated ... Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly ... Granins (chromogranins or secretogranins) [PMID: 2053134] are a family of acidic proteins present in the secretory granules of ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR001990
  • Chromogranin A can be either measured in the serum or detected by immunohistochemistry in a tissue specimen. (medscape.com)
  • Serum chromogranin A can be elevated in other situations and conditions, including chronic proton-pump inhibitors use, renal failure, liver failure, heart failure, rheumatoid arthritis, inflammatory bowel disease, and hypertension. (medscape.com)
  • ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to evaluate the impact of age on CgA diagnostic significance. (unipg.it)
  • Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. (ox.ac.uk)
  • Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
  • Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. (uky.edu)
  • Glinicki P, Jeske W. Chromogranin A (CgA)--the influence of various factors in vivo and in vitro, and existing disorders on its concentration in blood. (medscape.com)
  • Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were associated with a significant increased risk of disease progression. (endocrine-abstracts.org)
  • Chromogranin A can be used, in conjunction with other testing modalities, as a diagnostic tool, but caution is advised since it is elevated in many other conditions. (medscape.com)
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