A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Condensed areas of cellular material that may be bounded by a membrane.
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETEROTRIMERIC G-PROTEINS. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues.
A plant family of the order THEALES, subclass Dilleniidae, class Magnoliopsida, best known for CAMELLIA SINENSIS, which is the source of Oriental TEA.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
Individual's rights to obtain and use information collected or generated by others.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules. (1/53)

The disulfide-bonded loop of chromogranin B (CgB), a regulated secretory protein with widespread distribution in neuroendocrine cells, is known to be essential for the sorting of CgB from the trans-Golgi network (TGN) to immature secretory granules. Here we show that this loop, when fused to the constitutively secreted protein alpha1-antitrypsin (AT), is sufficient to direct the fusion protein to secretory granules. Importantly, the sorting efficiency of the AT reporter protein bearing two loops (E2/3-AT-E2/3) is much higher compared with that of AT with a single disulfide-bonded loop. In contrast to endogenous CgB, E2/3-AT-E2/3 does not undergo Ca2+/pH-dependent aggregation in the TGN. Furthermore, the disulfide-bonded loop of CgB mediates membrane binding in the TGN and does so with 5-fold higher efficiency if two loops are present on the reporter protein. The latter finding supports the concept that under physiological conditions, aggregates of CgB are the sorted units of cargo which have multiple loops on their surface leading to high membrane binding and sorting efficiency of CgB in the TGN.  (+info)

Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. (2/53)

Chromogranin A (CgA) and chromogranin B (CgB) are acidic proteins stored in and released from hormone granules in endocrine and neuroendocrine tissue. The chromogranins are postulated to serve as pro-hormones to generate biologically active peptides, which may influence hormonal release and vascular functions or have antibacterial functions. Although N-terminal and C-terminal regions show some species amino acid homology, the chromogranins as a whole display considerable interspecies differences, which prevents their use in comparative studies of biological functions. We present four new radioimmunoassays for the measurement of defined N-terminal regions of CgA and CgB. A new radioimmunoassay for measurement of intact bovine CgA has also been developed. With these assays and two previously published ones, we have compared the cross-reactivity of chromogranins from man, cattle, sheep, goat, pig and horse and compared adrenomedullar content and serum levels of CgA from these species. We have also studied the influence of peptide concentrations and the ionic strength of the mobile phase on molecular weight estimations. Assays with antibodies directed against the N-terminal parts of CgA and CgB showed sufficient interspecies cross-reactivity to allow comparative quantification of the circulating levels in man, cattle, sheep, goat, pig and horse. Assays measuring the intact human or bovine CgA were not suitable for comparative purposes in samples from sheep, goat, pig and horse. Molecular interactions between vasostatin immunoreactive material and intact bovine CgA were demonstrated in gel permeation studies, suggesting that conclusions about the degree of N-terminal processing from elution profiles should be made with caution. Reliable interspecies comparison of chromogranins is difficult, but measurements with region-specific assays may be helpful to study concentrations of chromogranins and chromogranin-related peptides.  (+info)

Identification and characterization of novel chromogranin B-derived peptides from porcine chromaffin granules by liquid chromatography/electrospray tandem MS. (3/53)

Chromogranin B (CgB) is a regulated secretory protein that is stored in endocrine and neuroendocrine cells. It can be processed proteolytically to small peptide fragments. In the present study three proteolytic products of porcine CgB were obtained after size-exclusion, immunoaffinity, and reversed-phase chromatography, and then identified by electrospray tandem MS. One novel peptide was identified as S586-R602 (SR-17) and is phosphorylated at one or two serine residues. Another novel peptide H603-Q636 (HQ-34), with molecular mass 3815.56 Da, was found to be oxidized at the methionine residue. In addition, a secretolytin-like peptide fragment (KR-11), which is two amino acids shorter than the bovine secretolytin, was found. This is the first report that the C-terminal region of CgB, the homologue of human CCB, is proteolytically processed further into three small peptide fragments.  (+info)

Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides. (4/53)

Chromogranin B (CgB) is a member of the granin family of neuroendocrine secretory proteins, which has been proposed to play a role in secretory granule biogenesis and as a precursor to bioactive peptides. The cloning of CgB in a phylogenetically distant vertebrate, the frog Rana ridibunda, reveals a modest overall homology (35-40%) with mammalian CgB. However, the sequences of the N- and C-terminal regions are more highly conserved (57-65% amino acid identity) and may give rise to novel regulatory peptides. In frog, intense expression of CgB mRNA was observed in particular structures of the brain and in the distal lobe of the pituitary.  (+info)

Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control. (5/53)

Chromogranins A (CGA) and B (CGB) are two major Ca(2+) storage proteins of the secretory granules of neuroendocrine cells. Nevertheless, we found in the present study that CGB was also localized in the nucleus. In immunogold electron microscopy using bovine adrenal medullary chromaffin cells, it was found that the number of CGB-labeled gold particles localized per microm(2) of the nucleus was equivalent to 20% that of CGB-labeled gold particles localized per microm(2) of the secretory granules. Considering that CGB is estimated to exist in the 0.1-0.2-mm range in the secretory granules of bovine chromaffin cells, 20% of these amounts to 20-40 microm. In addition, transfection of CGA and CGB into nonneuroendocrine COS-7 and NIH3T3 cells repeatedly indicated the nuclear localization of CGB in addition to its usual localization in the cytoplasm. Moreover, immunoblot and immunogold electron microscopy analyses of neuroendocrine PC12 cells also showed the existence of endogenous CGB in both the cytosol and the nucleus. Nuclear routing of CGB did not appear to depend entirely upon the nuclear localization signal as some of the nuclear localization signal mutant CGB were still targeted to the nucleus. In gene array assay, CGB was shown to either induce or suppress transcription of many genes including those of transcription factors. Of these we have analyzed eight genes, four induced (zinc finger protein, MEF2C, hCRP2, abLIM) and four suppressed (hcKrox, T3-receptor, troponin C, integrin) using the quantitative reverse transcription-PCR method and spectrophotometry to determine the transcription levels of each mRNA. CGB was shown to increase the transcription of zinc finger protein, MEF2C, hCRP2, and abLIM by 2.5-5-fold while suppressing that of hcKrox, T3-receptor, troponin C, and integrin by 60-75%. Given that MEF2C and hcKrox genes are transcription factors, these results pointed to the transcription control role of CGB in the nucleus.  (+info)

Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. (6/53)

Chromogranin A (CGA) and chromogranin B (CGB) are acidic proteins stored in secretory organelles of endocrine cells and neurons. In addition to their roles as helper proteins in the packaging of peptides, they may serve as prohormones to generate biologically active peptides such as vasostatin-1 and secretolytin. These molecules derived from CGA and CGB, respectively, possess antimicrobial properties. The present study demonstrates that plasmatic levels of both vasostatin-1 and secretolytin increase during surgery in patients undergoing cardiopulmonary bypass (CPB). Vasostatin-1 and secretolytin, initially present in plasma at low levels, are released just after skin incision. Consequently, they can be added to enkelytin, an antibacterial peptide derived from proenkephalin A, for the panoply of components acting as a first protective barrier against hypothetical invasion of pathogens, which may occur during surgery. CGA and CGB, more commonly viewed as markers for endocrine and neuronal cells, were also found to have an immune origin. RNA messengers coding for CGB were amplified by reverse transcription-polymerase chain reaction in human monocytes, and immunocytochemical analysis by confocal microscopy revealed the presence of CGA or CGB or both in monocytes and neutrophils. A combination of techniques including confocal microscopic analysis, mass spectrometry measurement, and antibacterial tests allowed for the identification of the positive role of interleukin 6 (IL-6) in the secretolytin release from monocytes in vitro. Because IL-6 release is known to be strongly enhanced during CPB, we suggest a possible relationship between IL-6 and the increased level of secretolytin in patients undergoing CPB.  (+info)

Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. (7/53)

The two major proteins of secretory granules of secretory cells, chromogranins A (CGA) and B (CGB), have previously been proposed to play key roles in secretory granule biogenesis. Recently, CGA was reported to play an on/off switch role for secretory granule biogenesis. In the present study we found CGB being more effective than CGA in inducing secretory granule formation in non-neuroendocrine NIH3T3 and COS-7 cells. The mean number of dense core granules formed/cell of CGA-transfected NIH3T3 cells was 2.51, whereas that of CGB-transfected cells was 4.02, indicating the formation of 60% more granules in the CGB-transfected cells. Similarly, there were 55% more dense core granules formed in the CGB-transfected COS-7 cells than in the CGA-transfected cells. Moreover, transfection of CGA- and CGB-short interfering RNA (siRNA) into neuroendocrine PC12 cells not only decreased the amount of CGA and CGB expressed but also reduced the number of secretory granules by 41 and 78%, respectively, further suggesting the importance of CGB expression in secretory granule formation.  (+info)

A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. (8/53)

Chromogranins A and B (CGA and CGB) are high capacity, low affinity calcium (Ca2+) storage proteins found in many cell types most often associated with secretory granules of secretory cells but also with the endoplasmic reticulum (ER) lumen of these cells. Both CGA and CGB associate with inositol 1,4,5-trisphosphate receptor (InsP3R) in a pH-dependent manner. At an intraluminal pH of 5.5, as found in secretory vesicles, both CGA and CGB bind to the InsP3R. When the intraluminal pH is 7.5, as found in the ER, CGA totally dissociates from InsP3R, whereas CGB only partially dissociates. To investigate the functional consequences of the interaction between the InsP3R and CGB monomers or CGA/CGB heteromers, purified mouse InsP3R type I were fused to planar lipid bilayers and activated by 2 microM InsP3. In the presence of luminal CGB monomers or CGA/CGB heteromers the InsP3R/Ca2+ channel open probability and mean open time increased significantly. The channel activity remained elevated when the pH was changed to 7.5, a reflection of CGB binding to the InsP3R even at pH 7.5. These results suggest that CGB may play an important modulatory role in the control of Ca2+ release from the ER. Furthermore, the difference in the ability of CGA and CGB to regulate the InsP3R/Ca2+ channel and the variability of CGA/CGB ratios could influence the pattern of InsP3-mediated Ca2+ release.  (+info)

Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp ...
Neuroendocrine tumours (NETs) are rare tumours that originate from neuroendocrine cells and their incidence has increased for the last 20 decades; partly because of advances in diagnostic tools, which have improved detection rates. Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. As a result, we hypothesised that plasma CgB concentration is a more accurate and reliable prognostic indicator in NET patients. Data from 121 NET patients were collected retrospectively and submitted to statistical analyses. In univariate survival analysis, circulating CgB levels were associated with a significantly poorer survival time than CgA. In addition, multivariate analysis was performed by considering other prognostic ...
CHGB - CHGB (Myc-DDK-tagged)-Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company.
Complete information for CHGB gene (Protein Coding), Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Introduction: Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). CgA assays may have different sensitivities, which is of importance for the clinical diagnosis and handling of NET patients ...
Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. TFH cells produce high amounts of dopamine and release it upon cognate interaction with B cells. Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. Mathematical modelling suggests that faster dopamine-induced T-B-cell interactions increase total germinal centre output and accelerate
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
CHGB Fragment MS Protein Standard, is a protein fragment containing a 50-150 amino acid sequence identical to part of a human CHGB protein target. The fragment MS Protein Standard represents a new category of using heavy isotope labeled (15N, 13C) Lysine and Arginine residues resulting in more than 99% isotope incorporation, as internal MS standards offering distinct advantages to existing products for relative and absolute quantification.
Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension Academic Article ...
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. Unlike neuroendocrine tissues, pancreatic islets of these animals lacked compensatory changes in other granins and were therefore analyzed in detail. Stimulated secretion of insulin, glucagon and somatostatin was reduced in CgB-ko islets, in parallel with somewhat impaired glucose clearance and reduced insulin release, but normal insulin sensitivity in vivo. CgB-ko islets lacked specifically the rapid initial phase of stimulated secretion, had elevated basal insulin release, and stored and released twice as much proinsulin as wildtype (wt) islets. Stimulated release of
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
a proportion of human TFH [follicular helper T] cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. TFH cells produce high amounts of dopamine and release it upon cognate interaction with B cells ,,. ,, faster dopamine-induced T-B-cell interactions increase total germinal centre output and accelerate it by days ,,. Ilenia Papa, David Saliba, et al. TFH-derived dopamine accelerates productive synapses in germinal centres. Nature 547, 318-323 (July 20, 2017) doi: 10.1038/nature23013. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23013.html. Kate Prestt. Discovery of brain-like activity in immune system promises better disease treatments. July 13, 2017. http://www.anu.edu.au/news/all-news/discovery-of-brain-like-activity-in-immune-system-promises-better-disease-treatments. ...
Gros-Louis F, Andersen PM, Dupré N, Urushitani M, Dion P, Souchon F, et al. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc Natl Acad Sci USA. 2009;106(51):21777-82. ...
Title:Advances in Systemic Therapy for Gastroenteropancreatic Neuroendocrine Malignancies. VOLUME: 10 ISSUE: 4. Author(s):Thorvardur R. Halfdanarson and Jonathan R. Strosberg. Affiliation:Mayo Clinic, Division of Medical Oncology, 200 First Street SW, Rochester, MN 55905, USA.. Keywords:Carcinoid tumors, neuroendocrine tumors, targeted therapy, therapy.. Abstract:Neuroendocrine tumors (NETs) are relatively uncommon. They typically arise in the gastrointestinal tract and lungs, and their incidence seems to be rising. Most patients have advanced disease at the time of diagnosis and many more will relapse after surgery. There is thus a great need for improvements in therapy for advanced neuroendocrine tumors. This article reviews the current therapy for both pancreatic NETs and non-pancreatic gastrointestinal NETs, and discusses recent advances in NET management with an emphasis on targeted therapy.. ...
Program in Evidence-based Care (PEBC) Directors Review. Following the presentation of this evidence-based series (EBS) draft report for Expert Panel review, the report was reviewed and approved by the director of the PEBC, Dr. Melissa Brouwers, with expertise in methodologic issues.. In response to the RAP review feedback, all the raised points were revised by the Working Group.. External Review by Ontario Clinicians and Other Experts. The PEBC external review process is two pronged and includes a targeted peer review intended to obtain direct feedback on the draft report from a small number of specified content experts and a professional consultation intended to facilitate dissemination of the final guidance report to Ontario practitioners.. Following the review and discussion of Section 1: Guideline Recommendations and Section 2: Evidentiary Base of this EBS and the review and approval of the report by the PEBC RAP, the guideline authors circulated Sections 1 and 2 to external review ...
Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II.
Biosynthetic transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is mediated by secretory vesicles. We analyzed secretory vesicle transport in real time using a GFP-tagged secretory protein, hCgB-GFP, consisting of human chromogranin B (hCgB) and green fluorescent protein (GFP). The fusion protein was expressed transiently in Vero cells or in a stable clone after induction with butyrate. After arrest of the biosynthetic protein transport at 20 degrees C, fluorescent hCgB-GFP colocalized with TGN38, a marker of the TGN. Subsequent release of the secretion block at 37 degrees C led to the formation of green fluorescent vesicles. Confocal analysis revealed that these vesicles were devoid of TGN38 and of Texas Red-coupled transferrin and cathepsin D, markers of the endosomal/lysosomal pathway. As determined by fluorometry and metabolic labelling hCgB-GFP was secreted from the TGN to the PM with a t(1/2) of 20-30 minutes. Video-microscope analysis of green fluorescent vesicles ...
A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary tree including pancreatic duct, with periampullary 30 mm mass lesion projecting into lumen of duodenum. Enlarged nodes were seen around the superior mesenteric artery. This was confirmed on MRI liver. Fasting gut hormones were normal except for a mildly elevated somatostatin level. Chromogranin A was elevated at 78 pmol/L with normal chromogranin B. Duodenoscopy and biopsy showed possible tubovillous adenoma with ...
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. MTC cells do not concentrate radioactive iodine and are not sensitive to hormonal manipulation. Surgery is currently the only therapy that can reliably lead to cure, reduction in tumor burden, or effective palliation. In patients with hereditary MTC, central lymph node dissection should be considered in preventative operations if the calcitonin level is elevated. Systematic surgical removal of at-risk or involved lymph node basins (compartmental dissection) should be performed in all patients with palpable primary tumors and recurrent disease. A berry-picking approach is discouraged. Although data are limited, standard chemotherapy and radiation therapy have not been shown to be effective in the treatment of MTC. Newer targeted drug therapies are promising and are being examined in therapeutic clinical trials. ...
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Blast transformation of rabbit B-derived lymphocytes by a mitogen extracted from Nocardia.: Nocardia water soluble mitogen (NWSM) is known to stimulate mouse an
Professor of Medicine at CUMC Dr. Fojo received his MD and PhD from the University of Miami and completed internal medicine training at Washington University School of Medicine / Barnes Hospital. He joined the National Cancer Institute in 1982 as a Clinical Associate in the Medicine Branch and after training with Drs. Ira Pastan and Michael Gottesman, became a Principal Investigator in the Medicine Branch of the National Cancer Institute. As a Principal Investigator he went on to establish a highly successful translational clinical program that began by exploring agents to reverse drug resistance, continued with work on the optimal use of Taxol®, and the development of novel microtubule-targeting agents and has focused on the development of therapies for endocrine and neuroendocrine cancers. Dr. Fojo has expertise in the management of patients with adrenocortical cancer, malignant pheochromocytoma and other neuroendocrine malignancies, and thyroid cancer. These cancers also comprise areas of very
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion Academic Article ...
SCG5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 aa (27-212 a.a.) having a molecular mass of 22 kDa.
Mouse monoclonal antibody raised against full length recombinant human CHGA. Recombinant protein corresponding to full length human CHGA. (MAB14233) - Products - Abnova
Excessive activation of the hypothalamic pituitary adrenal (HPA) axis has been associated with numerous diseases, including depression, and the tricyclic antidepressant imipramine has been shown to suppress activity of the HPA axis. Central hypothalamic control of the HPA axis is complex and involves a number of neuropeptides released from multiple hypothalamic subnuclei. The present study was therefore designed to determine the effects of imipramine administration on the mouse hypothalamus using a peptidomics approach. Among the factors found to be downregulated after acute (one day) or chronic (21 days) imipramine administration were peptides derived from secretogranin 1 (chromogranin B) as well as peptides derived from cerebellin precursors. In contrast, peptides SRIF-14 and SRIF-28 (1-11) derived from somatostatin (SRIF, somatotropin release inhibiting factor) were significantly upregulated by imipramine in the hypothalamus. Because diminished SRIF levels have long been known to occur in ...
The possibility of differentiating between chromaffin vesicles with different catecholamine contents was tested by studying the distribution of rabbit adrenal dopamine β-hydroxylase (EC 1.14.21) and catecholamines, and the buoyant densities of the catecholamine storage vesicles after isopycnic centrifugation of crude storage vesicle fractions in sucrose density gradients. Catecholamine storage vesicles were prepared from adrenal glands of untreated rabbits, rabbits which had received chlorisondamine chloride (10/kg intraperitoneally) to block ganglionic transmission, and rabbits which had received both chlorisondamine chloride and reserpine (1 mg kg). Adrenal glands were examined 1 day after treatmenmt with chlorisondamine and 1 and 8 days after combined treatment with chlorisondamine and reserpine. Intact storage vesicles obtained from glands of untreated animals had a specific gravity of 1.27, while the membranes obtained from vesicles lysed in distilled water had a specific gravity of 1.12. ...
Carcinoid tumors are rare (2.5 to 5.0 cases per 100,000 of the population per year), slow-growing neuroendocrine malignancies with significant potential to produce hepatic metastases and release excessive amounts of vasoactive amines into the systemic circulation (1). As a consequence, up to 15% of patients may develop carcinoid syndrome, with cutaneous flushing, gastrointestinal hypermotility, and cardiac involvement. Cardiac manifestations, also known as carcinoid heart disease (CaHD), are caused by endocardial deposition of pearly fibrotic plaques (notable for absence of elastic fibers) that generally extend to the right-sided valves, leading to multiple patterns of severe valve dysfunction. Plaque formation causes annular constriction, leaflet thickening, and fusion of the subvalvular apparatus. Marked degeneration of the leaflet architecture leads to severe retraction and noncoaptation of the valve, which remains fixed in a semiopen position (2). In this setting, valve replacement is the ...
Though most types of thyroid cancer are cured by surgery and adjuvant radio- iodine therapy and TSH suppression, patients with radio-iodine refractory thyroid carcinoma as well as with medullary thyroid carcinoma, a neuroendocrine malignancy that does not express iodine transporter, are difficult to treat because of the lack of effective systemic treatment. Therefore, there is an urgent need of novel therapeutic measures for these patients. Thyroid cancer is frequently associated to the oncogenic conversion of protein kinases such as RET (medullary thyroid cancer) and BRAF (papillary and undifferentiated thyroid cancer). Therefore, protein kinase small molecule inhibitors (PKI) have been considered as promising novel agents for the treatment of thyroid carcinoma. Compounds that revealed good RET and BRAF activity both in clinical (vandetanib for RET) and in pre-clinical (vemurafenib for BRAF) settings have been identified. Recently, vandetanib was approved for patients with medullary thyroid ...
The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. Although the precise function of the chromogranins remains elusive, knowledge of their structure, distribution, and potential intracellular and extracellular roles, especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. Thus, measurement of its circulating concentration by radioimmunoassay may be a useful probe of exocytotic sympathoadrenal activity in humans, under both physiological and pathological conditions. Here, we explore the storage, structure, and function of chromogranin A, and parameters that influence its circulating levels. We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. ...
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TY - JOUR. T1 - PANCREASTATIN BINDING-SITES AND ACTION IN INTACT AND PERMEABILIZED RINM5F CELLS. AU - Szecowka, J. AU - Shibier, O. AU - Flatt, Peter. AU - Berggren, PO. AU - Ostenson, CG. AU - Efendic, S. PY - 1992/8. Y1 - 1992/8. M3 - Article. VL - 35. SP - A76. JO - Diabetologia. JF - Diabetologia. SN - 0012-186X. IS - Suppl.. ER - ...
TY - JOUR. T1 - TRANSPORT AND TURNOVER OF DOPAMINE‐β‐HYDROXYLASE (EC 1.14.2.1) IN SYMPATHETIC NERVES OF THE RAT. AU - Brimijoin, S.. PY - 1972/9. Y1 - 1972/9. N2 - Axoplasmic transport of dopamine‐β‐hydroxylase (DBH), a marker enzyme for catecholamine storage vesicles, was studied in sympathetic nerves of the rat. At 24 h after ligation of the sciatic nerve, there was a marked accumulation of DBH activity in the first 3 mm proximal to the ligature. Immediately distal to the ligature, a slight accumulation took place. Accumulation proximal to the ligature was a linear function of time for at least 6 h; the velocity of transport was calculated as 4.6 mm/h. Local application of 1 ·l of 0.1 M colchicine, caused a rapid increase in DBH activity in superior cervical ganglia. This increase remained linear for 22 h and its rate indicated a turnover time of 12 h for DBH in these ganglia. After application of colchicine to the ganglia, there was a decrease in DBH activity in the submaxillary ...
Secretory granules are specialized intracellular organelles that serve as a storage pool for selected secretory products. The exocytosis of secretory granules is markedly amplified under physiologically stimulated conditions. While granules have been recognized as post-Golgi carriers for almost 40 years, the molecular mechanisms involved in their formation from the trans-Golgi network are only beginning to be defined. This review summarizes and evaluates current information about how secretory proteins are thought to be sorted for the regulated secretory pathway and how these activities are positioned with respect to other post-Golgi sorting events that must occur in parallel. In the first half of the review, the emerging role of immature secretory granules in protein sorting is highlighted. The second half of the review summarizes what is known about the composition of granule membranes. The numerous similarities and relatively limited differences identified between granule membranes and other ...
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Complete information for CHGA gene (Protein Coding), Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
C-terminal PHD zinc-finger domain capable of binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional ...
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008 ...
The structure of the gene encoding bovine chromogranin-A has been determined by characterization of two isolated genomic clones. Chromogranin-A is encoded by eight exons, which organize the coding region into several distinct structural and functional domains. Exons 1-5 represent the highly conserved signal peptide and N-terminal domain, which are separated into regions corresponding to the signal peptide, N-terminal sequence, disulfide-bonded loop, and remainder of the conserved N-terminal domain. Exon 6 represents the variable domain and encodes a region that is identical to the novel chromogranin-A-derived peptide chromostatin. Exon 7 encodes the biologically active peptide pancreastatin as well as most of the conserved C-terminal domain, with the remainder found on exon 8. The mRNA sequence obtained from the gene contains five nucleotide differences from the consensus sequence of four reported bovine chromogranin-A cDNA clones. Two of the differences in the gene result in two amino acid changes in
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The adrenal gland is among the organs with the highest concentration of vitamin C in the body. Interestingly, both the adrenal cortex and the medulla accumulate such high levels of ascorbate. Ascorbic acid is a cofactor required both in catecholamine biosynthesis and in adrenal steroidogenesis. Here we provide an overview on the role of vitamin C in the adrenal cortex and medulla derived from in vitro and in vivo studies. In addition, recent insights gained from an animal model with a deletion in the gene for the ascorbic acid transporter will be summarized. Mutant mice lacking the plasma membrane ascorbic acid transporter (SVCT2) have severely reduced tissue levels of ascorbic acid and die soon after birth. There is a significant decrease of tissue catecholamine levels in the adrenals. On the ultrastructural level, adrenal chromaffin cells in SVCT2 null mice show depletion of catecholamine storage vesicles, signs of apoptosis, and increased glycogen storage. Decreased plasma levels of ...
Secretory granules contain specific proteins and other macromolecules that are destined for secretion into the extracellular space. This slide shows secretory granules in pancreatic acinar cells. Their size is approximately 1 µm in diameter, and they accumulate on the apical side of the cell above the nucleus. ...
Patient preparation: Patient must be fasting 10-12 hours prior to collection of specimen. Patient should not be on any medications that may influence Insulin levels, if possible, for at least 48 hours prior to collection. Specimen Type: SST Serum Container/Tube: Serum gel Submission Container/Tube: Plastic vial Specimen Volume: 2 mL Collection Instructions: Draw blood in a serum gel tube(s). Spin down and send 2 mL of serum frozen in a plastic vial.
Chemicals, Active / Peptides - Looking for an AHA from a supplier you can trust? Youve come to the right place. Grouped by individual categories, below youll find a comprehensive listing of companies to choose from, including those spotlighted at the top of each category.
Melkam A. Kebede, Angie T. Oler, Trillian Gregg, Allison J. Balloon, Adam Johnson, Kelly Mitok, Mary Rabaglia, Kathryn Schueler, Donald Stapleton, Candice Thorstenson, Lindsay Wrighton, Brendan J. Floyd, Oliver Richards, Summer Raines, Kevin Eliceiri, Nabil G. Seidah, Christopher Rhodes, Mark P. Keller, Joshua L. Coon, Anjon Audhya, Alan D. Attie. ...
Expression of CHGA () in adrenal gland tissue. Antibody staining with HPA017369, CAB000023, CAB040544, CAB055506 and CAB058688 in immunohistochemistry.
BHC Connect is an online collaborative environment intended to help our 14 hubs organize and interact with one another as well as their communities.
Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is cleaved into the ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...
An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...
... is a peptide hormone secreted from the chromogranin A-positive enteroendocrine cells called the K-cells in the mucous ...
Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's ...
... positive Synaptophysin Chromogranin Smooth muscle actin Desmin Carcinoembrionary antigen CD99 antigen; S-100 neurofilaments AFP ...
... chromogranin A (CgA), synaptophysin), are also quite frequently expressed in a significant proportion of rhabdoid cells. ...
"The chromogranins and counter-regulatory hormones: do they make homeostatic sense?". Journal of Physiology. 517 (3): 643-649. ...
1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells ...
This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[5] ...
The NCLs present with progressive loss of visual function and neurodevelopmental decline, seizure, myoclonic jerks and premature death. The CTSD gene is one of the identified eight genes the deficiency of which is responsible for NCLs.[10] It has been reported that a homozygous single nucleotide duplication in exon 6 could alter the reading frame and causes a premature stop codon at position 255. Over-expression of cathepsin D stimulates tumorigenicity and metastasis as well as initiation of tumor apoptosis. This protease has been regarded an independent marker of poor prognosis in breast cancer being correlated with the incidence of clinical metastasis.[21][22] Knock-out of CTSD gene would cause intestinal necrosis and hemorrhage and increase apoptosis in thymus, indicating that cathepsin D is required in certain epithelial cells for tissue remodeling and renewal.[9] It is also reported that there might be a strong effect for CTSD genotype on Alzheimer disease risk in male.[23] Cathepsin D ...
GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity.[7][8] The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.. Several different laboratories studying the same protein, now called GAP43, initially used different names. It was designated F1, then B-50, then GAP43, pp46, and finally neuromodulin, each name reflecting a different function of the same molecule.[9] F1 was ...
... was first described in 1976,[16] first purified in 1977,[17] the gene was cloned in 1989,[6] and the first knockout mouse was created in 1996.[18] The function of desmin has been deduced through studies in knockout mice. Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the somites.[12] Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. A similar protein, vimentin, is present in higher amounts during embryogenesis while desmin is present in higher amounts after differentiation. This suggests that there may be some interaction between the two in determining muscle cell differentiation. However desmin knockout mice develop normally and only experience defects later in life.[13] Since desmin is expressed at a low level during differentiation another protein may be able to compensate for desmin's function early in development but not ...
Serum markers: elevated serum chromogranin A levels. Pathology[edit]. In most DIPNECH cases, upon examination of the lung ...
SCLC derived from neuroendocrine cells may express CD56, neural cell adhesion molecule, synaptophysin or chromogranin.[1] ...
... chromogranin)等等[1]。 ...
... chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated.[8] In total, 85% of ...
Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been ... This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by ... Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours?. Nipuni E Wanniachchi Wanigasekara, Paul Bech & ... Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were ...
68 Serum chromogranin A as tumor marker in neuroendocrine tumors. Introduction: Serum chromogranin A (CgA) is used as a tumor ... Introduction: Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be ... 783 A Comparison of Three Chromogranin A Assays in Patients with Neuroendocrine Tumors. Introduction: Chromogranin A (CgA) is ... 487 Validation of Chromogranin A Assays in Patients with Neuroendocrine Tumors. Introduction: CgA is the most important ...
Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... chromogranin B (catecholamine and norepenephrine secretory protein) *CHGB. UniProtKB/Swiss-Prot Function: Secretogranin-1 is a ... Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) ...
"The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal ... "Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.". ...
Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. ... Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB ... Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice. Obermüller S, Calegari F, King A, Lindqvist A, ... Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice. PLOS ONE 5(1): e8936. https://doi.org/10.1371/journal. ...
Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company. ... Chgb (untagged) - Mouse chromogranin B (Chgb), (10ug). $190. Next day. MR209967. Chgb (Myc-DDK-tagged) - Mouse chromogranin B ( ... CHGB (GFP-tagged) - Human chromogranin B (secretogranin 1) (CHGB). pCMV6-AC-GFP. pLenti-C-Myc-DDK. pLenti-C-mGFP. $610. In ... Chgb (GFP-tagged) - Mouse chromogranin B (Chgb). $920. 3 weeks. MR209967L1. Lenti ORF clone of Chgb (Myc-DDK-tagged) - Mouse ...
Chromogranin-B, Secretogranin I. Uniprot ID. P05060. Protein Name. Secretogranin-1. Description. CHGB Fragment MS Protein ...
Gros-Louis F, Andersen PM, Dupré N, Urushitani M, Dion P, Souchon F, et al. Chromogranin B P413L variant as risk factor and ...
a proportion of human TFH [follicular helper T] cells contain dense-core granules marked by chromogranin B, which are normally ...
... which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. ... Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally ... Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally ... which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. ...
Chromogranin B * Hypertension * Promoter Regions, Genetic abstract * The common CHGB promoter variants A-296C and A-261T, and ...
The chromogranin A test (CgA) is used in combination with 5-HIAA to help diagnose carcinoid tumors and may also be used to ... The chromogranin A (CgA) test is used as a tumor marker. It may be ordered alone or in combination with a 5-HIAA test to help ... The level of chromogranin A in the blood is normally low. If you have no signs or symptoms and a normal level of CgA, it is ... Chromogranin A (CgA) is a protein released from neuroendocrine cells. These are cells that release hormones in response to ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
The level of chromogranin A in the blood is normally low. A person with no signs or symptoms and a normal level of CgA is ... The chromogranin A (CgA) test is used as a tumor marker. It may be ordered in combination with a 5-HIAA test to help diagnose ... Should everyone have a chromogranin A test?. No. This test is usually ordered to help diagnose and monitor a carcinoid or other ... Chromogranin A can also be increased in people who take proton pump inhibitors (PPIs), which are drugs that reduce the amount ...
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.. *Secretogranin 2 (chromogranin C): A sulfated ... Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly ... Granins (chromogranins or secretogranins) [PMID: 2053134] are a family of acidic proteins present in the secretory granules of ...
It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. ... Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the ... It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. Chromogranin A contains ... encoded search term (Chromogranin%20A) and Chromogranin A What to Read Next on Medscape. Medscape Consult. ...
Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer, D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines ...
Rabbit polyclonal Chromogranin A antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Dog, Human, Pig, Monkey. ... Anti-Chromogranin A antibody (ab45179) at 1/1000 dilution (purified) + PC-12 cell lysate at 20 µg. Secondary. Goat Anti-Rabbit ... Anti-Chromogranin A antibody (ab45179) at 1/5000 dilution (purified) + SH-SY5Y cell lysate at 10 µg. Secondary. Goat Anti- ... Anti-Chromogranin A antibody (ab45179) at 1/10000 dilution (unpurified) + PC-12 cell lysate at 10 µg. Secondary. HRP-conjugated ...
References for Abcams Anti-Chromogranin C antibody (ab96589). Please let us know if you have used this product in your ...
Evaluation of psychosomatic stress in children by measuring salivary chromogranin A.. Lee T1, Shimizu T, Iijima M, Obinata K, ... To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction ...
Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J Biol Chem. 2003; 278 ... Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell. 2001; 106: 499-509. ... Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005; 115: 1942-1952 ... A panel of 11 region-specific radioimmunoassays for measurements of human chromogranin A. Regul Pept. 2004; 117: 219-227. ...
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... chromogranin explanation free. What is chromogranin? Meaning of chromogranin medical term. What does chromogranin mean? ... Looking for online definition of chromogranin in the Medical Dictionary? ... Chromogranin , definition of chromogranin by Medical dictionary https://medical-dictionary.thefreedictionary.com/chromogranin ... chromogranin. Also found in: Acronyms, Wikipedia. chro·mo·gran·in. (krōmō-granin), A soluble and secretory hormone proteins ...
Jetzt Chromogranins versandkostenfrei online kaufen & per Rechnung bezahlen bei Weltbild.de, Ihrem Bücher-Spezialisten! ... Rezension zu „Chromogranins ". I recommend Chromogranins for students and basic scientists interested not only in chromogranins ... Proteolytic processing of chromogranins; A. Laslop, et al. 13. Endothelial handling of chromogranin A; M. Mandalà, et al. 14. ... Inhaltsverzeichnis zu „Chromogranins ". Part 1: Introduction. 1. The chromogranins: Historical perspectives; K.B. Helle. 2. ...
chromogranin-A , chromogranin A , cgA , SP-I , betagranin (N-terminal fragment of chromogranin A) , parathyroid secretory ... Chromogranin A (CHGA) Antigen-Profil Beschreibung des Gens The protein encoded by this gene is a member of the chromogranin/ ... anti-Chromogranin A (CHGA) Antikörper. Bezeichnung:. anti-Chromogranin A Antikörper (CHGA). Auf www.antikoerper-online.de ... Weitere Antikörper gegen Chromogranin A Interaktionspartner. Zebrafish Chromogranin A (CHGA) Interaktionspartner * Study ...
Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Chromogranin A is a T cell antigen in human type 1 diabetes J Autoimmun. 2014 May;50:38-41. doi: 10.1016/j.jaut.2013.10.003. ... Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Keywords: Autoantigen; Autoreactive CD4 T cells; Chromogranin A; Human; Post-translational modification; Type 1 diabetes. ...
anti-Chromogranin A, PerCP, Clone: SPM553, Novus Biologicals 100 Tests; PerCP Life Sciences:Antibodies:Primary Antibodies:Flow ... betagranin (N-terminal fragment of chromogranin A), CGA, chromogranin A (parathyroid secretory protein 1), chromogranin-A, ... Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. It is validated for Western Blot, Flow ... Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and ...
Secretogranin II (chromogranin C), bImported. ,p>Information which has been imported from another database using automatic ... tr,A0JMK6,A0JMK6_DANRE Secretogranin II (chromogranin C), b OS=Danio rerio OX=7955 GN=scg2b PE=2 SV=1 ...
Shop a large selection of products and learn more about Thermo Scientific Lab Vision Chromogranin A Ab-1, Mouse Monoclonal ... Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Host Species: Mouse. ... Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout ... reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse ...
Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/ ... CHGA, CGA, Chromogranin-A, Vasostatin I, SP-I, Pituitary secretory protein I. ...
Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Bioclinica Lab employs a manual sandwich radioimmunoassay designed for the measurement of whole and fragmented Chromogranin A ...
Mouse Monoclonal Anti-Chromogranin A Antibody (SPM553) [DyLight 650]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (SPM553) [DyLight 650] ... Reviews for Chromogranin A Antibody (NBP2-34795C) (0) There are no reviews for Chromogranin A Antibody (NBP2-34795C). By ... Alternate Names for Chromogranin A Antibody (SPM553) [DyLight 650]. *betagranin (N-terminal fragment of chromogranin A) ...
Study Using Chromogranin A as Surveillance Biomarker in Patients with cARcinoids. * Print details ... The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II ...
Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific ... Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. It has a general ...
Mouse Monoclonal Anti-Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (PHE5) [Alexa Fluor® 700] ... Alternate Names for Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. *betagranin (N-terminal fragment of chromogranin A) ... PTMs for Chromogranin A Antibody (NBP2-34709AF700). Learn more about PTMs related to Chromogranin A Antibody (NBP2-34709AF700). ...
... chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to amyotrophic ... Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis Proc Natl Acad Sci ... Recently, chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to ...
The antibodies were raised to N-terminal of purified chromogranin A. These antibodies reacted with human chromogranin A as ... Chromogranin A (CgA) is considered to be a common marker for the GI endocrine cells [30-32]. The CgA cell density was ... L. Taupenot, K. L. Harper, and D. T. OConnor, "The chromogranin-secretogranin family," The New England Journal of Medicine, ... L. J. Deftos, "Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker," Endocrine ...
Chromogranin A ELISA from Cisbio Bioassays is a superior sandwich assay for the quantitative determination of CgA in human ... CisBios Chromoa® Chromogranin A ELISA. Chromoa®. The Chromoa® Chromogranin A ELISA from Cisbio Bioassays is for the ... Chromogranin A. Chromogranin A (CgA) is a glycoprotein widely expressed in endocrine and neuroendocrine cells. CgA is a ... Applications for Chromogranin A. Research has demonstrated several applications for Chromogranin A level measurements:. *CgA ...
Gratzl, Manfred (1987): Distibution of the Ca2+ binding protein chromogranin A in the pancreatic islet. In: Heym, Christine ( ...
Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB ... Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. ... Defective secretion of islet hormones in chromogranin-B deficient mice. Obermüller, Stefanie ...
  • Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed. (enets.org)
  • Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (ulaval.ca)
  • Dopamine causes rapid translocation of intracellular ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) to the B-cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area. (ox.ac.uk)
  • Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were associated with a significant increased risk of disease progression. (endocrine-abstracts.org)
  • Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. (endocrine-abstracts.org)
  • Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. (fishersci.com)
  • Obtain accurate, reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse Monoclonal Antibody. (fishersci.com)
  • There are currently no images for Chromogranin A Antibody (NBP2-34795C). (novusbio.com)
  • This antibody recognizes Chromogranin A, which is present in neuroendocrine cells. (biotium.com)
  • PC-12 cells were subjected to SDS PAGE followed by western blot with 10529-1-AP (Chromogranin A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 40x lens). (ptglab.com)
  • Immunofluorescent analysis of (4% PFA) fixed mouse pancreas tissue using 10529-1-AP (Chromogranin A antibody), at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). (ptglab.com)
  • The objective of this study was to develop and validate a time-resolved immunofluorometric assay (TR-IFMA) for porcine salivary chromogranin A (CgA) measurements, using a species-specific antibody, and evaluate its behaviour in an acute stress model. (semanticscholar.org)
  • Enzyme-linked immunosorbent assay for detection of canine chromogranin A by use of immunological cross-reactivity of rabbit anti-bovine chromogranin A antibody. (semanticscholar.org)
  • This antibody is designed for the specific localization of human Chromogranin A using IHC techniques in formalin-fixed, paraffin-embedded tissue sections. (gennovascientific.com)
  • Western Blot analysis of PC-3 cells using Chromogranin A Polyclonal Antibody at dilution of 1:500. (elabscience.com)
  • Immunohistochemistry of paraffin-embedded Human duodenum using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
  • Immunohistochemistry of paraffin-embedded Mouse small intestine using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
  • Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
  • Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. (nih.gov)
  • CHGB, also known as secretogranin-1 or chromogranin-B, is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. (creativebiomart.net)
  • Chromogranin A: current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway (1995) Iacangelo Anna L et al. (naver.com)
  • Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • Fingerprint Dive into the research topics of 'Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
  • Fingerprint Entra nei temi di ricerca di 'A Critical Approach to Clinical Biochemistry of Chromogranin A'. Insieme formano una fingerprint unica. (unicatt.it)
  • Most pituitary adenomas and prolactinomas readily express chromogranin. (fishersci.com)
  • Previous studies have indicated that plasma concentrations of chromogranin A (CGA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in healthy individuals, and this can make interpretation of results more complicated. (bibsys.no)
  • Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix. (thefreedictionary.com)
  • To identify which segment of CgA (chromogranin A) is important to induce the formation of such granule-like structures, a series of deletion constructs fused to either GFP (green fluorescent protein) or a short epitope tag was expressed in COS-1 fibroblast cells and analysed by fluorescence and electron microscopy and pulse-chase labelling. (portlandpress.com)
  • The diversity of chromogranins sharing common structural features but with possible non-redundant functions implies a variety of secretory granule populations whose existence and function remain to be established in a given neuroendocrine cell type. (springer.com)
  • The present chapter deals with the role of the different members of the chromogranin family in the processes of hormone aggregation, secretory granule biogenesis, and hormone sorting through their interaction with the TGN membrane. (springer.com)
  • Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are poorly understood. (biologists.org)
  • Synthetic peptide corresponding to Human Chromogranin A aa 1-100 (N terminal). (abcam.com)
  • Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat hea. (nih.gov)
  • 1993. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. (biotium.com)
  • The two most commonly used immunohistochemical markers for neuroendocrine cells and their tumors are chromogranin A (CgA) and synaptophysin (SPY). (bjbms.org)
  • The immunohistochemical expression of chromogranin A (CGA) was investigated in 60 normal mucosas, 95 primary tumours and 38 metastatic lymph nodes. (elsevier.com)
  • Chromogranin A Rabbit-Poly rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
  • Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
  • Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
  • Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets (Langerhans's cells). (gennovascientific.com)
  • Background: Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (idhinhibitor.com)
  • Background- Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. (ahajournals.org)
  • Methods and Results- Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. (ahajournals.org)
  • Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi N-W, O'Connor DT, Mahata SK (2012) Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. (springer.com)
  • Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. (uky.edu)
  • This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. (endocrine-abstracts.org)
  • This study was designed to assess diagnostic utility of chromogranin A (CgA) alone or in combination with NMN in patients with PHEO/PGL related to mutations in SDHB and SDHD. (cdc.gov)
  • However, chromogranin A might have some prognostic significance. (medscape.com)
  • Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. (endocrine-abstracts.org)
  • It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. (medscape.com)
  • Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. (diva-portal.org)
  • Chromogranin A (CgA), originally identified in adrenal chromaffin cells, is a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. (ovid.com)
  • Chen Y, Rao F, Rodriguez-Flores JL et al (2008) Naturally occurring human genetic variation in the 3′-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (springer.com)
  • We conclude that secretory stimulation of pheochromocytoma cells also activates the biosynthesis of the major secreted protein (chromogranin A), that the activation is transcriptional, and that a small proximal domain, including the CRE box, is, at least in part, both necessary and sufficient to account for the positive response to nicotine. (elsevier.com)
  • The granin (chromogranin/secretogranin) family. (ebi.ac.uk)
  • Chromogranin A (CgA), a member of the granin family serves several important cell biological roles in (neuro)endocrine cells which are summarized in this review. (fujita-hu.ac.jp)
  • Finally, the alteration of chromogranin secretion is described in pathophysiological conditions linked to dysregulated hormone secretion. (springer.com)
  • Chromogranins are members of a family of soluble glycoproteins sharing common structural features and properties, known to be inducers of prohormone aggregation and sorting into secretory granules. (springer.com)
  • Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed. (enets.org)
  • To explore stimulus-transcription coupling in pheochromocytoma cells, we studied the biosynthetic response of chromogranin A, the major soluble protein co-stored and co-released with catecholamines, to chromaffin cells' physiologic nicotinic cholinergic secretory stimulation. (elsevier.com)
  • SNEC showed strong reactivity with epithelial and neuroendocrine markers whereas ENB demonstrated immunoreactivity to synaptophysin and chromogranin strongly, with weak to negative expression of epithelial markers. (thefreedictionary.com)
  • Immunohisto-chemically solid pseudopapillary tumor of pancreas can show overlapping expression of pan CK, synaptophysin, CD56, chromogranin , CD10 and vimentin with neuroendocrine tumors19,20, the expression of neuroendocrine markers with pancreatoblastoma and pancreatic enzymes with acinar cell carcinoma18. (thefreedictionary.com)
  • Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
  • Tomita T. Significance of chromogranin A and synaptophysin in pancreatic neuroendocrine tumors. (bjbms.org)
  • Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients. (hindawi.com)
  • Chromogranin A (CgA) is considered to be a common marker for the GI endocrine cells [ 30 - 32 ]. (hindawi.com)
  • Chromogranin A (CgA) is a glycoprotein widely expressed in endocrine and neuroendocrine cells. (alpco.com)
  • Chromogranin A (CgA) is a common marker for endocrine cells. (uib.no)
  • These results establish that chromogranins A and B and secretogranin II are present in the endocrine pancreas, but that they exhibit a distinct cellular localization. (uni-muenchen.de)
  • Secretoneurin--a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C)". Neuroscience. (wikipedia.org)
  • Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. (weltbild.de)
  • Chromogranin A: is it a useful marker of neuroendocrine tumors? (radiopaedia.org)
  • A wide variety of neuroendocrine tumors stain positive for chromogranin A. (medscape.com)
  • Plasma chromogranin A (CgA) levels are elevated in a variety of neuroendocrine tumors (NETs) and are used to aid in diagnosis, prognosis, and monitoring of treatment effects in NETs patients. (enets.org)
  • The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II KRYPTOR Assay in patients with Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs). (mayo.edu)
  • There are several research applications for Chromogranin A measurements for which the assay can be utilized. (alpco.com)
  • Measurement of chromogranin A in porcine saliva: validation of a time-resolved immunofluorometric assay and evaluation of its application as a marker of acute stress. (semanticscholar.org)
  • In September 2001, the patient's serum serotonin and pancreatic polypeptide levels had risen even higher (1,386 ng/ml and 471 pg/ml, respectively), and his serum chromogranin A had more than tripled to 970 ng/ml (figure 4). (thefreedictionary.com)
  • Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. (naver.com)
  • Vasostatins, comprising the N-terminal domain of chromogranin A, suppress tension in isolated human blood vessel segments. (naver.com)
  • The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. (fishersci.com)
  • Chromogranin -A is useful in the diagnosis of all Neuroendocrine neoplasms. (lalpathlabs.com)
  • Bioclinica Lab employs a manual sandwich radioimmunoassay designed for the measurement of whole and fragmented Chromogranin A in serum. (bioclinica.com)
  • Chromogranin A is released as hormone in blood and can be used as biochemical marker. (gennovascientific.com)
  • Research has indicated there are multiple applications for Chromogranin A. Elevated serum CgA levels have been associated with prostate cancer and other neuroendocrine tumors. (alpco.com)
  • Recently, mixed forms between adenocarcinoma and neuroendocrine prostate cancer (NEPC) have emerged that are characterized by persistent androgen receptor (AR)-signalling and elevated chromogranin A (CgA) levels. (cdc.gov)
  • The most informative immunological analysis to reveal neuroendocrine differentiation (NED) in prostate cancer diagnostics is evaluation of Chromogranin A (ChA) level. (ecuro.ru)
  • ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to evaluate the impact of age on CgA diagnostic significance. (unipg.it)