Chromogranin B
A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.
Chromogranin A
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Chromogranins
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
Secretogranin II
A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.
Adrenal Medulla
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
PC12 Cells
Inositol 1,4,5-Trisphosphate Receptors
Pancreatic Hormones
Golgi Apparatus
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Dithiothreitol
Secretory Vesicles
Chromaffin Cells
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
Exocytosis
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Pheochromocytoma
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Nerve Endings
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Hepatitis C Antibodies
Antibody Specificity
Hepatitis Antibodies
Antibodies
Hepacivirus
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Saliva
Publishing
MEDLINE
Pressoreceptors
Carotid Sinus
Phenotype
Peptide Fragments
Irritable Bowel Syndrome
Gastrointestinal Diseases
Avidin
Colonic Diseases, Functional
Biotin
Constipation
Synaptophysin
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Neurosecretory Systems
Phospholipase C beta
Theaceae
Fluorescent Dyes
Organic Chemicals
The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules. (1/53)
The disulfide-bonded loop of chromogranin B (CgB), a regulated secretory protein with widespread distribution in neuroendocrine cells, is known to be essential for the sorting of CgB from the trans-Golgi network (TGN) to immature secretory granules. Here we show that this loop, when fused to the constitutively secreted protein alpha1-antitrypsin (AT), is sufficient to direct the fusion protein to secretory granules. Importantly, the sorting efficiency of the AT reporter protein bearing two loops (E2/3-AT-E2/3) is much higher compared with that of AT with a single disulfide-bonded loop. In contrast to endogenous CgB, E2/3-AT-E2/3 does not undergo Ca2+/pH-dependent aggregation in the TGN. Furthermore, the disulfide-bonded loop of CgB mediates membrane binding in the TGN and does so with 5-fold higher efficiency if two loops are present on the reporter protein. The latter finding supports the concept that under physiological conditions, aggregates of CgB are the sorted units of cargo which have multiple loops on their surface leading to high membrane binding and sorting efficiency of CgB in the TGN. (+info)Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. (2/53)
Chromogranin A (CgA) and chromogranin B (CgB) are acidic proteins stored in and released from hormone granules in endocrine and neuroendocrine tissue. The chromogranins are postulated to serve as pro-hormones to generate biologically active peptides, which may influence hormonal release and vascular functions or have antibacterial functions. Although N-terminal and C-terminal regions show some species amino acid homology, the chromogranins as a whole display considerable interspecies differences, which prevents their use in comparative studies of biological functions. We present four new radioimmunoassays for the measurement of defined N-terminal regions of CgA and CgB. A new radioimmunoassay for measurement of intact bovine CgA has also been developed. With these assays and two previously published ones, we have compared the cross-reactivity of chromogranins from man, cattle, sheep, goat, pig and horse and compared adrenomedullar content and serum levels of CgA from these species. We have also studied the influence of peptide concentrations and the ionic strength of the mobile phase on molecular weight estimations. Assays with antibodies directed against the N-terminal parts of CgA and CgB showed sufficient interspecies cross-reactivity to allow comparative quantification of the circulating levels in man, cattle, sheep, goat, pig and horse. Assays measuring the intact human or bovine CgA were not suitable for comparative purposes in samples from sheep, goat, pig and horse. Molecular interactions between vasostatin immunoreactive material and intact bovine CgA were demonstrated in gel permeation studies, suggesting that conclusions about the degree of N-terminal processing from elution profiles should be made with caution. Reliable interspecies comparison of chromogranins is difficult, but measurements with region-specific assays may be helpful to study concentrations of chromogranins and chromogranin-related peptides. (+info)Identification and characterization of novel chromogranin B-derived peptides from porcine chromaffin granules by liquid chromatography/electrospray tandem MS. (3/53)
Chromogranin B (CgB) is a regulated secretory protein that is stored in endocrine and neuroendocrine cells. It can be processed proteolytically to small peptide fragments. In the present study three proteolytic products of porcine CgB were obtained after size-exclusion, immunoaffinity, and reversed-phase chromatography, and then identified by electrospray tandem MS. One novel peptide was identified as S586-R602 (SR-17) and is phosphorylated at one or two serine residues. Another novel peptide H603-Q636 (HQ-34), with molecular mass 3815.56 Da, was found to be oxidized at the methionine residue. In addition, a secretolytin-like peptide fragment (KR-11), which is two amino acids shorter than the bovine secretolytin, was found. This is the first report that the C-terminal region of CgB, the homologue of human CCB, is proteolytically processed further into three small peptide fragments. (+info)Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides. (4/53)
Chromogranin B (CgB) is a member of the granin family of neuroendocrine secretory proteins, which has been proposed to play a role in secretory granule biogenesis and as a precursor to bioactive peptides. The cloning of CgB in a phylogenetically distant vertebrate, the frog Rana ridibunda, reveals a modest overall homology (35-40%) with mammalian CgB. However, the sequences of the N- and C-terminal regions are more highly conserved (57-65% amino acid identity) and may give rise to novel regulatory peptides. In frog, intense expression of CgB mRNA was observed in particular structures of the brain and in the distal lobe of the pituitary. (+info)Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control. (5/53)
Chromogranins A (CGA) and B (CGB) are two major Ca(2+) storage proteins of the secretory granules of neuroendocrine cells. Nevertheless, we found in the present study that CGB was also localized in the nucleus. In immunogold electron microscopy using bovine adrenal medullary chromaffin cells, it was found that the number of CGB-labeled gold particles localized per microm(2) of the nucleus was equivalent to 20% that of CGB-labeled gold particles localized per microm(2) of the secretory granules. Considering that CGB is estimated to exist in the 0.1-0.2-mm range in the secretory granules of bovine chromaffin cells, 20% of these amounts to 20-40 microm. In addition, transfection of CGA and CGB into nonneuroendocrine COS-7 and NIH3T3 cells repeatedly indicated the nuclear localization of CGB in addition to its usual localization in the cytoplasm. Moreover, immunoblot and immunogold electron microscopy analyses of neuroendocrine PC12 cells also showed the existence of endogenous CGB in both the cytosol and the nucleus. Nuclear routing of CGB did not appear to depend entirely upon the nuclear localization signal as some of the nuclear localization signal mutant CGB were still targeted to the nucleus. In gene array assay, CGB was shown to either induce or suppress transcription of many genes including those of transcription factors. Of these we have analyzed eight genes, four induced (zinc finger protein, MEF2C, hCRP2, abLIM) and four suppressed (hcKrox, T3-receptor, troponin C, integrin) using the quantitative reverse transcription-PCR method and spectrophotometry to determine the transcription levels of each mRNA. CGB was shown to increase the transcription of zinc finger protein, MEF2C, hCRP2, and abLIM by 2.5-5-fold while suppressing that of hcKrox, T3-receptor, troponin C, and integrin by 60-75%. Given that MEF2C and hcKrox genes are transcription factors, these results pointed to the transcription control role of CGB in the nucleus. (+info)Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. (6/53)
Chromogranin A (CGA) and chromogranin B (CGB) are acidic proteins stored in secretory organelles of endocrine cells and neurons. In addition to their roles as helper proteins in the packaging of peptides, they may serve as prohormones to generate biologically active peptides such as vasostatin-1 and secretolytin. These molecules derived from CGA and CGB, respectively, possess antimicrobial properties. The present study demonstrates that plasmatic levels of both vasostatin-1 and secretolytin increase during surgery in patients undergoing cardiopulmonary bypass (CPB). Vasostatin-1 and secretolytin, initially present in plasma at low levels, are released just after skin incision. Consequently, they can be added to enkelytin, an antibacterial peptide derived from proenkephalin A, for the panoply of components acting as a first protective barrier against hypothetical invasion of pathogens, which may occur during surgery. CGA and CGB, more commonly viewed as markers for endocrine and neuronal cells, were also found to have an immune origin. RNA messengers coding for CGB were amplified by reverse transcription-polymerase chain reaction in human monocytes, and immunocytochemical analysis by confocal microscopy revealed the presence of CGA or CGB or both in monocytes and neutrophils. A combination of techniques including confocal microscopic analysis, mass spectrometry measurement, and antibacterial tests allowed for the identification of the positive role of interleukin 6 (IL-6) in the secretolytin release from monocytes in vitro. Because IL-6 release is known to be strongly enhanced during CPB, we suggest a possible relationship between IL-6 and the increased level of secretolytin in patients undergoing CPB. (+info)Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. (7/53)
The two major proteins of secretory granules of secretory cells, chromogranins A (CGA) and B (CGB), have previously been proposed to play key roles in secretory granule biogenesis. Recently, CGA was reported to play an on/off switch role for secretory granule biogenesis. In the present study we found CGB being more effective than CGA in inducing secretory granule formation in non-neuroendocrine NIH3T3 and COS-7 cells. The mean number of dense core granules formed/cell of CGA-transfected NIH3T3 cells was 2.51, whereas that of CGB-transfected cells was 4.02, indicating the formation of 60% more granules in the CGB-transfected cells. Similarly, there were 55% more dense core granules formed in the CGB-transfected COS-7 cells than in the CGA-transfected cells. Moreover, transfection of CGA- and CGB-short interfering RNA (siRNA) into neuroendocrine PC12 cells not only decreased the amount of CGA and CGB expressed but also reduced the number of secretory granules by 41 and 78%, respectively, further suggesting the importance of CGB expression in secretory granule formation. (+info)A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. (8/53)
Chromogranins A and B (CGA and CGB) are high capacity, low affinity calcium (Ca2+) storage proteins found in many cell types most often associated with secretory granules of secretory cells but also with the endoplasmic reticulum (ER) lumen of these cells. Both CGA and CGB associate with inositol 1,4,5-trisphosphate receptor (InsP3R) in a pH-dependent manner. At an intraluminal pH of 5.5, as found in secretory vesicles, both CGA and CGB bind to the InsP3R. When the intraluminal pH is 7.5, as found in the ER, CGA totally dissociates from InsP3R, whereas CGB only partially dissociates. To investigate the functional consequences of the interaction between the InsP3R and CGB monomers or CGA/CGB heteromers, purified mouse InsP3R type I were fused to planar lipid bilayers and activated by 2 microM InsP3. In the presence of luminal CGB monomers or CGA/CGB heteromers the InsP3R/Ca2+ channel open probability and mean open time increased significantly. The channel activity remained elevated when the pH was changed to 7.5, a reflection of CGB binding to the InsP3R even at pH 7.5. These results suggest that CGB may play an important modulatory role in the control of Ca2+ release from the ER. Furthermore, the difference in the ability of CGA and CGB to regulate the InsP3R/Ca2+ channel and the variability of CGA/CGB ratios could influence the pattern of InsP3-mediated Ca2+ release. (+info)
Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B
Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours? | SFEBES2015
OriGene - CHGB (NM 001819) Human ORF cDNA Clone
CHGB Gene - GeneCards | SCG1 Protein | SCG1 Antibody
An Isolated Abnormal Chromogranin B Is Associated with Pancreato-Duodenal NETs and the Presence of Liver Metastases
TFH-derived dopamine accelerates productive synapses in germinal centres. - The Kennedy Institute of Rheumatology
Chromogranin B | ALZFORUM
CHGB Fragment MS Protein Standard - Creative Proteomics
Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic...
PLOS ONE: accelerating the publication of peer-reviewed science
CHGB - Secretogranin-1 precursor - Homo sapiens (Human) - CHGB gene & protein
Qiu-Xing Jiang | Hauptman-Woodward Medical Research Institute
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Publications | Page 7 | Cervo Brain Research Centre
Produktübersicht anti-CHGB Antikörper
BHC3 Well Development Optimization - BakerHughesC3.ai
Advances in Systemic Therapy for Gastroenteropancreatic Neuroendocrine Malignancies | Bentham Science
Radionuclide therapy for neuroendocrine malignancies Clinical Practice Guidelines
Chromogranin A: Reference Range, Interpretation, Collection and Panels
Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein | Journal of...
Browse In Weight loss, Gender, Investigation, Diabetes, White, Duodenum, Female, Fine needle aspiration biopsy | EDM Case...
Search Results | JNCCN
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein elisa and antibody
Blast transformation of rabbit B-derived lymphocytes by a mito...
Tito A. Fojo, MD, PhD | Columbia University Department of Surgery
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated...
Complex Renal Traits: Role of Adrenergic Genetic Polymorphism | American Society of Nephrology
SCG5 Protein Human Recombinant | Secretogranin V | ProSpec
CHGA monoclonal antibody, clone CHGA/777 - (MAB14233) - Products - Abnova
SCG2 Gene - GeneCards | SCG2 Protein | SCG2 Antibody
Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant...
Plus it
Carcinoid Heart Disease | JACC: Journal of the American College of Cardiology
Protein Kinase inhibitors for the treatment of thyroid cancer: molecular mechanisms of resistance - fedOA
Chromogranin A. Storage and release in hypertension. | Hypertension
WikiGenes - SCG2 - secretogranin II
PANCREASTATIN BINDING-SITES AND ACTION IN INTACT AND PERMEABILIZED RINM5F CELLS<...
TRANSPORT AND TURNOVER OF DOPAMINE‐β‐HYDROXYLASE (EC 1.14.2.1) IN SYMPATHETIC NERVES OF THE RAT<...
Sorting and storage during secretory granule biogenesis: looking backward and looking forward | Biochemical Journal
Secretogranin III ELISA Kits | Biocompare.com
Genatlas sheet
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas<...
The bovine chromogranin A gene: structural basis for hormone regulation and generation of biologically active peptides. -...
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Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla. - Wellness Resources
Secretory Granules
FPCNS - Overview: Pancreastatin, Serum
Chemicals, Active / Peptides - HAPPI
JCI -
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells
Tissue expression of CHGA - Staining in adrenal gland - The Human Protein Atlas
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SCG5
Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. ... Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic ...
SCG3
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... "Entrez Gene: SCG3 secretogranin III". Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) ... "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of ...
Granin
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of ...
SCG2
2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human ... Chromogranin Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... 2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1-3): 13-21. doi:10.1016/j.regpep.2008.07. ...
Pheochromocytoma
If metanephrine values are equivocal, chromogranin A can be used as an adjunct marker to predict the presence of a tumor. ... Other additional biomarkers can be helpful to aid in the diagnosis of pheochromocytoma as well, most notable is Chromogranin A ... d'Herbomez M, Do Cao C, Vezzosi D, Borzon-Chasot F, Baudin E (September 2010). "Chromogranin A assay in clinical practice". ... However, a 2006 report from Italy found that over 90% of studied pheochromocytoma patients demonstrated elevated chromogranin A ...
Carcinoid syndrome
Chromogranin A and platelets serotonin are increased.[clarification needed] Transthoracic echocardiogram shows valve thickening ... Nobels FR, Kwekkeboom DJ, Bouillon R, Lamberts SW (1998). "Chromogranin A: its clinical value as marker of neuroendocrine ... Markers of the condition such as chromogranin-A are imperfect indicators of disease progression. Prognosis varies from ...
Solid pseudopapillary tumour
... they are negative for chromogranin and pancreatic enzymes. The diagnosis of solid pseudopapillary tumour of the pancreas is ...
Ceruminous adenoma
The cells are negative with chromogranin, synaptophysin and CK20. The major diagnosis from which to separate ceruminous adenoma ...
Saliva testing
Soell M, Feki A, Hannig M, Sano H, Pinget M, Selimovic D (February 2010). "Chromogranin A detection in saliva of type 2 ... chromogranin A) was over-expressed in 100% of diabetic patients when compared to controls. In 2010 Qvarnstrom, et al., ...
Homeostasis
"The chromogranins and counter-regulatory hormones: do they make homeostatic sense?". Journal of Physiology. 517 (3): 643-649. ...
Secretoneurin
Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is cleaved into the ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...
Homeostasis
Koeslag, Johan H.; Saunders, Peter T.; Wessels, Jabus A. (1999). "The chromogranins and counter-regulatory hormones: do they ...
Neuroendocrine tumor
Aside from the hormones of secretory tumors, the most important markers are: chromogranin A (CgA), present in 99% of metastatic ... Neuroendocrine secretory protein-55, a member of the chromogranin family, is seen in pancreatic endocrine tumors but not ... Widely used neuroendocrine tissue markers are various chromogranins, synaptophysin and PGP9.5. Neuron-specific enolase (NSE) is ... chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated. Functional tumors are ...
Lung cancer
... or chromogranin. Lung cancer staging is an assessment of the degree of spread of the cancer from its original source. It is one ...
Secretogranin-1
... , also known as Chromogranin B, is a protein that in humans is encoded by the CHGB gene. It is a member of the ...
B3GAT1
Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal ... conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin ...
MIA PaCa-2
... chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56. The cells have a round, epithelial morphology, and are adherent ...
Mepartricin
"Increased chromogranin A and neuron-specific enolase in rats with chronic nonbacterial prostatitis induced by 17-beta estradiol ...
Pancreatic neuroendocrine tumor
... chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. In total, 85% of ... immunohistochemistry is generally positive for chromogranin and synaptophysin. Genetic testing thereof typically shows altered ...
Péptido YY, a enciclopedia libre
1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells ...
Synaptophysin
Diagnostically, it is often used in combination with chromogranin A. List of human genes Synaptophysin has been shown to ...
Molecular diagnostics
"Selective localization of the parathyroid secretory protein-I/adrenal medulla chromogranin A protein family in a wide variety ...
Zollinger-Ellison syndrome
An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...
Paraganglioma
With immunohistochemistry, the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron ...
Neuroendocrine differentiation
Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely ... chromogranin A (CgA), synaptophysin and neuron-specific enolase (NSE) (three proteins that are used as markers for ... chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or ...
Neuroendocrine cell
... chromogranin A, gastrin-releasing peptide (GRP), and cholecystokinin. These cells can be the source of several types of lung ...
Xenin
... is a peptide hormone secreted from the chromogranin A-positive enteroendocrine cells called the K-cells in the mucous ...
Multiple endocrine neoplasia type 1
Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's ...
Papillary tumors of the pineal region
Chromogranin → - NSE (neuron-specific enolase) → ++ NFP (neurofilament protein) → - CD56/N-CAM (neural cell adhesion molecule ...
CGA
... a glycoprotein hormone Chromogranin A, a member of the granin family of neuroendocrine secretory proteins A codon for the amino ...
Chromogranin A - Wikipedia
In humans, chromogranin A protein is encoded by the CHGA gene. Examples of cells producing chromogranin A (ChgA) are chromaffin ... Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. See chromogranin A ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory ...
Chromogranin A | ALZFORUM
Chromogranin A | LabCorp
The level of chromogranin A in the blood is normally low. A person with no signs or symptoms and a normal level of CgA is ... The chromogranin A (CgA) test is used as a tumor marker. It may be ordered in combination with a 5-HIAA test to help diagnose ... Should everyone have a chromogranin A test?. No. This test is usually ordered to help diagnose and monitor a carcinoid or other ... Chromogranin A can also be increased in people who take proton pump inhibitors (PPIs), which are drugs that reduce the amount ...
Chromogranin A/B/C (IPR001990) | InterPro | EMBL-EBI
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.. *Secretogranin 2 (chromogranin C): A sulfated ... Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly ... Granins (chromogranins or secretogranins) [PMID: 2053134] are a family of acidic proteins present in the secretory granules of ...
Chromogranin A: Reference Range, Interpretation, Collection and Panels
It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. ... Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the ... It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. Chromogranin A contains ... encoded search term (Chromogranin A) and Chromogranin A What to Read Next on Medscape ...
Chromogranin A (LK2H10) Mouse Monoclonal Antibody
... ; find Sigma-Aldrich-238M9 MSDS, related peer-reviewed papers, technical ... Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin- ... Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles ... The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA ...
Chromogranin B ELISA Kits | Biocompare
Compare Chromogranin B ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... Chromogranin B ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and ... Your search returned 95 Chromogranin B ELISA ELISA Kit across 16 suppliers. ...
Chromogranin A. Storage and release in hypertension. | Hypertension
Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer, D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines ...
Anti-Chromogranin A antibody (ab45179) | Abcam
Rabbit polyclonal Chromogranin A antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Dog, Human, Pig, Monkey. ... Anti-Chromogranin A antibody (ab45179) at 1/1000 dilution (purified) + PC-12 cell lysate at 20 µg. Secondary. Goat Anti-Rabbit ... Anti-Chromogranin A antibody (ab45179) at 1/5000 dilution (purified) + SH-SY5Y cell lysate at 10 µg. Secondary. Goat Anti- ... Anti-Chromogranin A antibody (ab45179) at 1/10000 dilution (unpurified) + PC-12 cell lysate at 10 µg. Secondary. HRP-conjugated ...
Anti-Chromogranin A Antibody Products | Biocompare
Compare Anti-Chromogranin A Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, ... Anti-Chromogranin A Antibody Products. Chromogranin A, also known as parathyroid secretory protein 1, or CGA is a secretory ... Chromogranin A is a well characterized cancer biomarker and is elevated in adrenal and gastrointestinal neuroendocrine tumors. ...
Anti-Chromogranin C antibody (ab96589) References
Evaluation of psychosomatic stress in children by measuring salivary chromogranin A. - PubMed - NCBI
Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation
Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J Biol Chem. 2003; 278 ... Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell. 2001; 106: 499-509. ... Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005; 115: 1942-1952 ... A panel of 11 region-specific radioimmunoassays for measurements of human chromogranin A. Regul Pept. 2004; 117: 219-227. ...
Lab Test: Chromogranin A | Akron Children's Hospital
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Chromogranin | definition of chromogranin by Medical dictionary
... chromogranin explanation free. What is chromogranin? Meaning of chromogranin medical term. What does chromogranin mean? ... Looking for online definition of chromogranin in the Medical Dictionary? ... Chromogranin , definition of chromogranin by Medical dictionary https://medical-dictionary.thefreedictionary.com/chromogranin ... chromogranin. Also found in: Acronyms, Wikipedia. chro·mo·gran·in. (krōmō-granin), A soluble and secretory hormone proteins ...
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Jetzt Chromogranins versandkostenfrei online kaufen & per Rechnung bezahlen bei Weltbild.de, Ihrem Bücher-Spezialisten! ... Rezension zu „Chromogranins ". I recommend Chromogranins for students and basic scientists interested not only in chromogranins ... Proteolytic processing of chromogranins; A. Laslop, et al. 13. Endothelial handling of chromogranin A; M. Mandalà, et al. 14. ... Inhaltsverzeichnis zu „Chromogranins ". Part 1: Introduction. 1. The chromogranins: Historical perspectives; K.B. Helle. 2. ...
anti-Chromogranin A Primary Antibodies
chromogranin-A , chromogranin A , cgA , SP-I , betagranin (N-terminal fragment of chromogranin A) , parathyroid secretory ... Chromogranin A (CHGA) Antigen-Profil Beschreibung des Gens The protein encoded by this gene is a member of the chromogranin/ ... anti-Chromogranin A (CHGA) Antikörper. Bezeichnung:. anti-Chromogranin A Antikörper (CHGA). Auf www.antikoerper-online.de ... Weitere Antikörper gegen Chromogranin A Interaktionspartner. Zebrafish Chromogranin A (CHGA) Interaktionspartner * Study ...
Chromogranin A is a T cell antigen in human type 1 diabetes
Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Chromogranin A is a T cell antigen in human type 1 diabetes J Autoimmun. 2014 May;50:38-41. doi: 10.1016/j.jaut.2013.10.003. ... Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Keywords: Autoantigen; Autoreactive CD4 T cells; Chromogranin A; Human; Post-translational modification; Type 1 diabetes. ...
anti-Chromogranin A, PerCP, Clone: SPM553, Novus Biologicals 100 Tests;
| Fisher Scientific
anti-Chromogranin A, PerCP, Clone: SPM553, Novus Biologicals 100 Tests; PerCP Life Sciences:Antibodies:Primary Antibodies:Flow ... betagranin (N-terminal fragment of chromogranin A), CGA, chromogranin A (parathyroid secretory protein 1), chromogranin-A, ... Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. It is validated for Western Blot, Flow ... Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and ...
scg2b - Secretogranin II (chromogranin C), b - Danio rerio (Zebrafish) - scg2b gene & protein
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
i,Background and Aim,/i,. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is ... Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome,. Gastroenterology Research ... Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with ... L. J. Deftos, "Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker," Endocrine ...
Thermo Scientific Lab Vision Chromogranin A Ab-1, Mouse Monoclonal Antibody
| Fisher Scientific
Shop a large selection of products and learn more about Thermo Scientific Lab Vision Chromogranin A Ab-1, Mouse Monoclonal ... Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Host Species: Mouse. ... Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout ... reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse ...
Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
CHGA Protein Human | Chromogranin A Recombinant | ProSpec
CHGA Human Protein | Recombinant Chromogranin A | ProSpec
Chromogranin A is a 439 amino acid protein which is encoded on chromosome 14 and is present in neuroendocrine cells throughout ... Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. ... CHGA, CGA, Chromogranin-A, Vasostatin I, SP-I, Pituitary secretory protein I. ...
CGA // Chromogranin A | Bioclinica
Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Bioclinica Lab employs a manual sandwich radioimmunoassay designed for the measurement of whole and fragmented Chromogranin A ...
Chromogranin A Antibody (SPM553) [DyLight 650] (NBP2-34795C): Novus Biologicals
Mouse Monoclonal Anti-Chromogranin A Antibody (SPM553) [DyLight 650]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (SPM553) [DyLight 650] ... Reviews for Chromogranin A Antibody (NBP2-34795C) (0) There are no reviews for Chromogranin A Antibody (NBP2-34795C). By ... Alternate Names for Chromogranin A Antibody (SPM553) [DyLight 650]. *betagranin (N-terminal fragment of chromogranin A) ...
Study Using Chromogranin A as Surveillance Biomarker in Patients with cARcinoids - Mayo Clinic
Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific...
Chromogranin A Antibody (PHE5) [Alexa Fluor® 700] (NBP2-34709AF700): Novus Biologicals
Mouse Monoclonal Anti-Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (PHE5) [Alexa Fluor® 700] ... Alternate Names for Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. *betagranin (N-terminal fragment of chromogranin A) ... PTMs for Chromogranin A Antibody (NBP2-34709AF700). Learn more about PTMs related to Chromogranin A Antibody (NBP2-34709AF700). ...
ChgAAntibodyImmunogenImmunohistochemistryRecombinantProteinsPeptidesBiomarkerCHGBParathyroid secretoryAntibodiesAntigenNeuron specifiMarkerPeptideSerum chromogranin A levelsProlactinomas readily express chromograninGranulePatients with Neuroendocrine TumorsFingerprintCatestatinImmunohistochemicalCarcinoidFull-length chromograninTumorPancreaticPancreasCoreleased with catecholamines by exocytosisLocalizationUtility of chromograninAssayAssaysPrognosticSolubleGraninsChromaffin cells of the adrenal medullaAcidicTumourProtein chromograninSecretogranin familySalivary chromograninSecretory granulesRabbitSecretionELISA KitSynaptophysinImmunoreactivityPlasmaVariety of neuroendocrine tumorsClinical
ChgA19
- Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins. (wikipedia.org)
- In humans, chromogranin A protein is encoded by the CHGA gene. (wikipedia.org)
- Examples of cells producing chromogranin A (ChgA) are chromaffin cells of the adrenal medulla, paraganglia, enterochromaffin-like cells and beta cells of the pancreas. (wikipedia.org)
- The catecholamine storage vesicle protein chromogranin A (CHGA) 1 plays a necessary role in formation of catecholamine secretory granules. (ahajournals.org)
- Auf www.antikoerper-online.de finden Sie aktuell 1025 Chromogranin A (CHGA) Antikörper von 40 unterschiedlichen Herstellern. (antikoerper-online.de)
- Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand for diabetogenic CD4 T cell clones derived from the NOD mouse. (nih.gov)
- In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. (diva-portal.org)
- Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/secretogranin family. (prospecbio.com)
- Anti-CHGA / Chromogranin A antibody IHC of human adrenal. (antibodies-online.com)
- We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545 US and 1252 Australian subjects. (diva-portal.org)
- Cleavage of the N- and C-terminal regions of circulating chromogranin A (CgA, CHGA), classically an anti-angiogenic protein, can activate latent anti- and pro-angiogenic sites, respectively. (aacrjournals.org)
- Adrenal medullary mRNA and protein levels of other dense-core secretory granule proteins including chromogranin B, and secretogranins II to VI were up-regulated 2- to 3-fold in the Chga null mutant mice. (ovid.com)
- General Description of Chromogranin A / CHGA. (enquirebio.com)
- Variations in Chromogranin A / CHGA antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
- Low, but measureable presence of Chromogranin A / CHGA could be seen inneuronal cells in the caudate nucleus, cerebral cortex and hippocampus, respiratory epithelial cells in the bronchus and neuronal cells in the caudate nucleus and cerebral cortex and hippocampus. (enquirebio.com)
- We were unable to detect Chromogranin A / CHGA in other tissues. (enquirebio.com)
- Tissues from cancer patients, for instance, have their own distinct pattern of Chromogranin A / CHGA expression as measured by anti-Chromogranin A / CHGA antibody immunohistochemical staining. (enquirebio.com)
- CHGA (Chromogranin A) is a Protein Coding gene. (genecards.org)
- It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. (fujita-hu.ac.jp)
Antibody16
- Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. (fishersci.com)
- Obtain accurate, reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse Monoclonal Antibody. (fishersci.com)
- There are currently no images for Chromogranin A Antibody (NBP2-34795C). (novusbio.com)
- This antibody recognizes Chromogranin A, which is present in neuroendocrine cells. (biotium.com)
- PC-12 cells were subjected to SDS PAGE followed by western blot with 10529-1-AP (Chromogranin A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. (ptglab.com)
- Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 10x lens). (ptglab.com)
- Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 40x lens). (ptglab.com)
- Immunofluorescent analysis of (4% PFA) fixed mouse pancreas tissue using 10529-1-AP (Chromogranin A antibody), at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). (ptglab.com)
- Immunofluorescent analysis of (-20°C Ethanol) fixed PC-12 cells using 60135-1-Ig (Chromogranin A antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). (ptglab.com)
- The objective of this study was to develop and validate a time-resolved immunofluorometric assay (TR-IFMA) for porcine salivary chromogranin A (CgA) measurements, using a species-specific antibody, and evaluate its behaviour in an acute stress model. (semanticscholar.org)
- Enzyme-linked immunosorbent assay for detection of canine chromogranin A by use of immunological cross-reactivity of rabbit anti-bovine chromogranin A antibody. (semanticscholar.org)
- This antibody is designed for the specific localization of human Chromogranin A using IHC techniques in formalin-fixed, paraffin-embedded tissue sections. (gennovascientific.com)
- This antibody is useful when demonstrating co-expression of chromogranin and NSE, which is typical of neuroendocrine neoplasms. (histopat.hu)
- Western Blot analysis of PC-3 cells using Chromogranin A Polyclonal Antibody at dilution of 1:500. (elabscience.com)
- Immunohistochemistry of paraffin-embedded Human duodenum using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
- Immunohistochemistry of paraffin-embedded Mouse small intestine using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
Immunogen1
- Immunogen: C-terminal half of Chromogranin A, purified from urine of patients with carcinoid syndrome. (idhinhibitor.com)
Immunohistochemistry6
- Chromogranin A can be either measured in the serum or detected by immunohistochemistry in a tissue specimen. (medscape.com)
- Chromogranin A Positive Control Slides, Product No. 238S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). (sigmaaldrich.com)
- immunohistochemistry demonstrates chromogranin A, synaptophysin, and usually serotonin and somatostatin positivity (Figure 1, A and B). (thefreedictionary.com)
- Immunohistochemistry studies using chromogranin and Ki67 markers confirmed the diagnosis. (thefreedictionary.com)
- Antisera against chromogranin A and B and secretogranin II were used for analysing the bovine pancreas by immunoblotting and immunohistochemistry. (uni-muenchen.de)
- In immunohistochemistry, chromogranin A was found in all pancreatic endocrine cell types with the exception of most pancreatic polypeptide-(PP-) producing cells. (uni-muenchen.de)
Recombinant3
- Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. (antibody-antibodies.com)
- Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
- GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant. (antibody-antibodies.com)
Proteins11
- Granins (chromogranins or secretogranins) [ PMID: 2053134 ] are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. (ebi.ac.uk)
- The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. (ahajournals.org)
- Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. (diva-portal.org)
- A general characteristic for NETs is their expression of certain proteins, such as chromogranin A (CgA), which is released from the dense core vesicles of NE cells, occasionally together with cell specific hormones, such as gastrin and serotonin. (enets.org)
- Chromogranin A was found in 1967 and is a member of the Granin family, a group of acidic, soluble secretory proteins. (slu.se)
- The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (nih.gov)
- Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as is a member of the granin family of proteins. (radiopaedia.org)
- Full Name: chromogranin A Background: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (idhinhibitor.com)
- Chromogranins belong to an evolutionarily conserved family of proteins that serve as neuropeptide proproteins and the secretogranin-II-derived peptide secretoneurin is a 33 amino acid polypeptide that exerts its effects by binding to specific receptors. (ronnyallan.net)
- The chromogranins comprise a class of acidic proteins that are secreted from large dense core vesicles and expressed in neuronal and endocrine tissues. (elsevier.com)
- Chromogranin A (CGA) is a member of the granin family of proteins which are widespread in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are typically found in secretory granules. (unicatt.it)
Peptides4
- Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. (wikipedia.org)
- Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
- Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. (nih.gov)
- CHGB, also known as secretogranin-1 or chromogranin-B, is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. (creativebiomart.net)
Biomarker6
- Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. (medscape.com)
- Chromogranin A is a well characterized cancer biomarker and is elevated in adrenal and gastrointestinal neuroendocrine tumors. (biocompare.com)
- Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours? (endocrine-abstracts.org)
- Chromogranin A is a molecule whose properties and functions has been investigated extensively, for example its potential as a biomarker. (slu.se)
- 7 August 2014 - A study, carried out by Chinese researchers and published today in BMC Endocrine Disorders, has demonstrated that Chromogranin A (CgA) is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumours (PNETs) but not for insulinomas. (thefreedictionary.com)
- The clinical relevance of chromogranin A as a biomarker for gastroentero-pancreatic neuroendocrine tumors. (thefreedictionary.com)
CHGB1
- Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are poorly understood. (biologists.org)
Parathyroid secretory1
- Chromogranin A, also known as parathyroid secretory protein 1, or CGA is a secretory protein and a member of the granin family. (biocompare.com)
Antibodies2
- Your search returned 1465 Chromogranin A Antibodies across 57 suppliers. (biocompare.com)
- Chromogranin A Rabbit-Poly rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
Antigen2
- Previous studies have indicated that plasma concentrations of chromogranin A (CGA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in healthy individuals, and this can make interpretation of results more complicated. (bibsys.no)
- Immunohistochemical studies were positive for synaptophysin and CD56 (NCAM), chromogranin A , epithelial antigen, and CAM 5.2/AE-1. (thefreedictionary.com)
Neuron specifi2
- Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. (fishersci.com)
- The currently used tumour markers for NETs are neuron-specific enolase (NSE) and chromogranin A (CgA). (elsevier.com)
Marker15
- The chromogranin A (CgA) test is used as a tumor marker. (labcorp.com)
- El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease. (antikoerper-online.de)
- Chromogranin A (CgA) is a common marker for endocrine cells. (hindawi.com)
- Chromogranin A (CgA) is a common marker for these endocrine cells [ 21 - 23 ], and consequently it has been found that CgA is reduced in these patients [ 24 ]. (hindawi.com)
- Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients. (hindawi.com)
- Chromogranin A (CgA) is considered to be a common marker for the GI endocrine cells [ 30 - 32 ]. (hindawi.com)
- Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). (enets.org)
- Serum chromogranin A (CgA) is used as a tumor marker for neuroendocrine tumors (NETs). (enets.org)
- Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. (endocrine-abstracts.org)
- This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. (endocrine-abstracts.org)
- The cases were stained for TTF-1, EMA, low-molecular-weight cytokeratin (CAM 5.2), endothelial cell marker (CD31), surfactant protein B (PE10), and chromogranin A . Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections. (thefreedictionary.com)
- BACKGROUND Serum chromogranin A (CgA), a marker of neuroendocrine neoplasia, increases during profound gastric acid inhibition, possibly reflecting the trophic effect of gastrin on the enterochromaffin-like (ECL) cells. (semanticscholar.org)
- Measurement of chromogranin A in porcine saliva: validation of a time-resolved immunofluorometric assay and evaluation of its application as a marker of acute stress. (semanticscholar.org)
- Chromogranin A is released as hormone in blood and can be used as biochemical marker. (gennovascientific.com)
- Chromogranin A: is it a useful marker of neuroendocrine tumors? (radiopaedia.org)
Peptide4
- Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. (wikipedia.org)
- Synthetic peptide corresponding to Human Chromogranin A aa 1-100 (N terminal). (abcam.com)
- Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat hea. (nih.gov)
- 1993. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. (biotium.com)
Serum chromogranin A levels1
- Clinical significance of elevated serum chromogranin A levels. (radiopaedia.org)
Prolactinomas readily express chromogranin1
- Most pituitary adenomas and prolactinomas readily express chromogranin. (sigmaaldrich.com)
Granule4
- Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix. (thefreedictionary.com)
- To identify which segment of CgA (chromogranin A) is important to induce the formation of such granule-like structures, a series of deletion constructs fused to either GFP (green fluorescent protein) or a short epitope tag was expressed in COS-1 fibroblast cells and analysed by fluorescence and electron microscopy and pulse-chase labelling. (portlandpress.com)
- The diversity of chromogranins sharing common structural features but with possible non-redundant functions implies a variety of secretory granule populations whose existence and function remain to be established in a given neuroendocrine cell type. (springer.com)
- The present chapter deals with the role of the different members of the chromogranin family in the processes of hormone aggregation, secretory granule biogenesis, and hormone sorting through their interaction with the TGN membrane. (springer.com)
Patients with Neuroendocrine Tumors1
- Chromogranin A, Ki-67 index and IGF-related genes in patients with neuroendocrine tumors. (medscape.com)
Fingerprint3
- Fingerprint Dive into the research topics of 'Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
- Fingerprint Dive into the research topics of 'Regulation of tumor growth by circulating full-length chromogranin A'. Together they form a unique fingerprint. (elsevier.com)
- Fingerprint Entra nei temi di ricerca di 'A Critical Approach to Clinical Biochemistry of Chromogranin A'. Insieme formano una fingerprint unica. (unicatt.it)
Catestatin4
- Background- Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. (ahajournals.org)
- Methods and Results- Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. (ahajournals.org)
- Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi N-W, O'Connor DT, Mahata SK (2012) Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. (springer.com)
- Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. (uky.edu)
Immunohistochemical2
- The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA)-positive tumour cells could be demonstrated in breast cancer cases found to be negative by conventional immunohistochemical staining. (sigmaaldrich.com)
- Detection of chromogranin A in human gastric adenocarcinomas using a sensitive immunohistochemical technique. (sigmaaldrich.com)
Carcinoid1
- Chromogranin A is a test conducted to diagnose Carcinoid tumours. (apollodiagnostics.in)
Full-length chromogranin1
- Regulation of tumor growth by circulating full-length chromogranin A . Oncotarget , 7 (45), 72716-72732. (elsevier.com)
Tumor4
- Immunohisto-chemically solid pseudopapillary tumor of pancreas can show overlapping expression of pan CK, synaptophysin, CD56, chromogranin , CD10 and vimentin with neuroendocrine tumors19,20, the expression of neuroendocrine markers with pancreatoblastoma and pancreatic enzymes with acinar cell carcinoma18. (thefreedictionary.com)
- Colombo B, Curnis F, Foglieni C, Monno A, Arrigoni G, Corti A (2002) Chromogranin A expression in neoplastic cells affects tumor growth and morphogenesis in mouse models. (springer.com)
- Diagnosis can be made by the clinical picture and supported by imaging, endoscopy, or tumor markers such as chromogranin A and serotonin. (thefreedictionary.com)
- Products to note from this catalog include Euro Diagnostica's gold standard anti-CCP ELISA, ANCA ELISA, Pertusscan ELISA, Complement, as well as endocrine and tumor markers including Chromogranin A and B assays. (thefreedictionary.com)
Pancreatic8
- Chromogranin A induces and promotes the generation of secretory granules such as those containing insulin in pancreatic islet beta cells. (wikipedia.org)
- Quantification of chromogranin A may be useful in confirming the diagnosis of a pancreatic NET and assessing for persistent, recurrent, or metastatic disease. (thefreedictionary.com)
- In September 2001, the patient's serum serotonin and pancreatic polypeptide levels had risen even higher (1,386 ng/ml and 471 pg/ml, respectively), and his serum chromogranin A had more than tripled to 970 ng/ml (figure 4). (thefreedictionary.com)
- Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
- Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
- The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II KRYPTOR Assay in patients with Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs). (mayo.edu)
- Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets (Langerhans's cells). (gennovascientific.com)
- Background: Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (idhinhibitor.com)
Pancreas1
- These results establish that chromogranins A and B and secretogranin II are present in the endocrine pancreas, but that they exhibit a distinct cellular localization. (uni-muenchen.de)
Coreleased with catecholamines by exocytosis1
- Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. (ahajournals.org)
Localization1
- Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. (sigmaaldrich.com)
Utility of chromogranin1
- This study was designed to assess diagnostic utility of chromogranin A (CgA) alone or in combination with NMN in patients with PHEO/PGL related to mutations in SDHB and SDHD. (cdc.gov)
Assay2
- There are several research applications for Chromogranin A measurements for which the assay can be utilized. (alpco.com)
- The authors want to thank Novartis Pharma AG for their support in providing Chromogranin A assay kits throughout the study. (thefreedictionary.com)
Assays2
- There are considerable differences in the amino acid composition between different species' chromogranin A . Commercial assays for measuring human CGA can usually not be used for measuring CGA in samples from other animals. (wikipedia.org)
- Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound ( 5 ) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. (rsc.org)
Prognostic1
- However, chromogranin A might have some prognostic significance. (medscape.com)
Soluble3
- Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles of adrenal medulla and sympathetic nerve. (sigmaaldrich.com)
- Chromogranins are members of a family of soluble glycoproteins sharing common structural features and properties, known to be inducers of prohormone aggregation and sorting into secretory granules. (springer.com)
- Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed. (enets.org)
Granins2
- It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. (medscape.com)
- Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. (diva-portal.org)
Chromaffin cells of the adrenal medulla1
- The most studied chromogranin is CgA, which was first isolated from chromaffin cells of the adrenal medulla as a single polypeptide chain of 439 amino acids and 10 dibasic cleavage sites. (thefreedictionary.com)
Acidic1
- Chromogranin A (CgA), originally identified in adrenal chromaffin cells, is a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. (ovid.com)
Tumour3
- Tyramide signal amplification discloses chromogranin A-positive tumour cells in more breast tumours than previously realized. (sigmaaldrich.com)
- Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were associated with a significant increased risk of disease progression. (endocrine-abstracts.org)
- Effect of environmental enrichment and herbal compound supplementation on physiological stress indicators (chromogranin A, cortisol and tumour necrosis factor-α) in growing pigs. (semanticscholar.org)
Protein chromogranin1
- Chen Y, Rao F, Rodriguez-Flores JL et al (2008) Naturally occurring human genetic variation in the 3′-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (springer.com)
Secretogranin family1
- The granin (chromogranin/secretogranin) family. (ebi.ac.uk)
Salivary chromogranin3
- Evaluation of psychosomatic stress in children by measuring salivary chromogranin A. (nih.gov)
- To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction on the suppression of stress in children. (nih.gov)
- Salivary chromogranin A as a measure of stress response to noise. (semanticscholar.org)
Secretory granules1
- Cowley DJ, Moore YR, Darling DS, Joyce PB, Gorr SU (2000) N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules. (springer.com)
Rabbit1
- Do not freeze taw, rather use Chromogranin A Rabbit-Poly from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
Secretion1
- Finally, the alteration of chromogranin secretion is described in pathophysiological conditions linked to dysregulated hormone secretion. (springer.com)
ELISA Kit1
- Your search returned 95 Chromogranin B ELISA ELISA Kit across 16 suppliers. (biocompare.com)
Synaptophysin2
- SNEC showed strong reactivity with epithelial and neuroendocrine markers whereas ENB demonstrated immunoreactivity to synaptophysin and chromogranin strongly, with weak to negative expression of epithelial markers. (thefreedictionary.com)
- Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
Immunoreactivity2
- Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. (sigmaaldrich.com)
- The chromogranin A immunoreactivity occurs in the majority of neuroendocrine cells but with variable intensity, length and intracellular distribution. (gennovascientific.com)
Plasma7
- We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. (ahajournals.org)
- The Chromoa® Chromogranin A ELISA from Cisbio Bioassays is for the quantitative determination of CgA in serum and plasma. (alpco.com)
- The Chromoa® Chromogranin A ELISA is a superior method for determining CgA levels in human serum or plasma. (alpco.com)
- Plasma chromogranin A (CgA) levels are elevated in a variety of neuroendocrine tumors (NETs) and are used to aid in diagnosis, prognosis, and monitoring of treatment effects in NETs patients. (enets.org)
- In contrast, survival sorted by normal vs abnormal plasma chromogranin A level was not statistically significant (p = 0.24). (cancerstaging.org)
- Measurement of plasma chromogranin A concentrations for assessment of stress responses in dogs with insulin-induced hypoglycemia. (semanticscholar.org)
- Plasma androgen receptor and serum chromogranin A in advanced prostate cancer. (cdc.gov)
Variety of neuroendocrine tumors1
- A wide variety of neuroendocrine tumors stain positive for chromogranin A. (medscape.com)
Clinical2
- Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. (weltbild.de)
- Chromogranin A. Clinical and investigative medicine. (radiopaedia.org)