AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and Occupations
Chromogranin APancreatic HormonesAdrenal MedullaNeuroendocrine TumorsChromaffin GranulesNeurosecretory SystemsCarcinoid TumorSynaptophysinCarcinoma, NeuroendocrineChromaffin SystemSecretogranin IIEndocrine GlandsSecretory VesiclesCatecholaminesEnterochromaffin-like CellsEnterochromaffin CellsPheochromocytomaEndocrine Gland NeoplasmsCytoplasmic GranulesCarboxypeptidase HChromaffin CellsNerve Tissue ProteinsNeoplasms, Nerve TissuePeptide FragmentsCattleAdrenal Gland NeoplasmsNeuroendocrine CellsTumor Markers, BiologicalImmunohistochemistryEnteroendocrine CellsProprotein Convertase 2Colitis, Lymphocytic
Chromogranin A
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Pancreatic Hormones
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
Adrenal Medulla
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Neuroendocrine Tumors
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Chromaffin Granules
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
Neurosecretory Systems
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
Carcinoid Tumor
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Synaptophysin
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Chromaffin System
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
Secretogranin II
A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.
Endocrine Glands
Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
Secretory Vesicles
Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.
Catecholamines
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Enterochromaffin-like Cells
Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to GASTRIN by releasing histamine which acts as a paracrine stimulator of the release of HYDROCHLORIC ACID from the GASTRIC PARIETAL CELLS.
Enterochromaffin Cells
A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain).
Pheochromocytoma
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Endocrine Gland Neoplasms
Tumors or cancer of the ENDOCRINE GLANDS.
Cytoplasmic Granules
Condensed areas of cellular material that may be bounded by a membrane.
Carboxypeptidase H
A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.
Chromaffin Cells
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
Nerve Tissue Proteins
Neoplasms, Nerve Tissue
Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Adrenal Gland Neoplasms
Tumors or cancer of the ADRENAL GLANDS.
Neuroendocrine Cells
Specialized NEURONS that produce hormones, such as NEUROPEPTIDES or BIOGENIC AMINES. They generally are in the NERVOUS SYSTEM, such as HYPOTHALAMUS, but can be found in other organs or systems. These neurons contain dense neurosecretory granules and PROPROTEIN CONVERTASES allowing the rapidly release of NEUROHORMONES into the blood circulation upon stimulation.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Enteroendocrine Cells
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
Proprotein Convertase 2
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
Colitis, Lymphocytic
A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (1/561)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Kinetics of neuroendocrine differentiation in an androgen-dependent human prostate xenograft model. (2/561)

It was previously shown in the PC-295 xenograft that the number of chromogranin A (CgA)-positive neuroendocrine (NE) cells increased after androgen withdrawal. NE cells did not proliferate and differentiated from G0-phase-arrested cells. Here we further characterized NE differentiation, androgen receptor status, and apoptosis-associated Bcl-2 expression in the PC-295 model after androgen withdrawal to assess the origin of NE cells. PC-295 tumor volumes decreased by 50% in 4 days. Intraperitoneal bromodeoxyuridine (BrdU) incorporation and MIB-1 labeling decreased to 0%, and the apoptosis was maximal at day 4. Androgen receptor expression and prostate-specific antigen (PSA) serum levels decreased rapidly within 2 days. The number of NE cells increased 6-fold at day 4 and 30-fold at day 7. Five and ten percent of the CgA-positive cells were BrdU positive after continuous BrdU labeling for 2 and 4 days, respectively. However, no MIB-1 expression was observed in CgA-positive cells. NE cells expressed the regulated secretory pathway marker secretogranin III but were negative for androgen receptor and Bcl-2. Bcl-2 expression did increase in the non-NE tumor cells. In conclusion, androgen withdrawal leads to a rapid PC-295 tumor regression and a proliferation-independent induction of NE differentiation. The strictly androgen-independent NE cells that were still present after 21 days differentiated mainly from G0-phase-arrested cells.  (+info)

Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation. (3/561)

OBJECTIVE: Islet amyloid polypeptide (IAPP), also named amylin, is the predominant protein component of amyloid deposits in human islet beta cell tumours of the pancreas (insulinomas). IAPP is co-produced with insulin by islet beta cells. We investigated IAPP expression in relation to insulin expression and to amyloid formation in eleven insulinomas. DESIGN AND METHODS: RNA and protein extracts were prepared from the same pieces of tumour tissue, and from specimens of two normal human pancreata. IAPP and insulin mRNA and peptide content were quantified using Northern blot analysis and radioimmunoassay (RIA) respectively. Molecular forms of IAPP immunoreactivity were analysed by reversed-phase high-performance liquid chromatography (HPLC). The presence of islet hormones and of amyloid was assessed by (immuno)histochemical staining of paraffin sections. Plasma levels of IAPP and insulin prior to tumour resection were determined by RIA. RESULTS: IAPP and insulin mRNA and peptide content varied widely between the tumour specimens, and there was considerable intratumour heterogeneity of peptide content. HPLC analysis indicated correct proteolytic processing of the IAPP precursor protein. Amyloid deposits were detected only in the three tumours with the highest IAPP content. In contrast to insulin, plasma levels of IAPP were not elevated in the insulinoma patients. CONCLUSIONS: The spectrum of hormone production by insulinomas cannot be inferred from only a few tissue sections due to intratumour heterogeneity. Expression of the IAPP and insulin genes is not coupled in insulinomas, which produce properly processed mature IAPP. In addition to IAPP overproduction, additional factors such as intracellular accumulation of IAPP are involved in amyloidogenesis in insulinomas.  (+info)

Library of sequence-specific radioimmunoassays for human chromogranin A. (4/561)

BACKGROUND: Human chromogranin A (CgA) is an acidic protein widely expressed in neuroendocrine tissue and tumors. The extensive tissue- and tumor-specific cleavages of CgA at basic cleavage sites produce multiple peptides. METHODS: We have developed a library of RIAs specific for different epitopes, including the NH2 and COOH termini and three sequences adjacent to dibasic sites in the remaining part of CgA. RESULTS: The antisera raised against CgA(210-222) and CgA(340-348) required a free NH2 terminus for binding. All antisera displayed high titers, high indexes of heterogeneity ( approximately 1.0), and high binding affinities (Keff0 approximately 0.1 x 10(12) to 1.0 x 10(12) L/mol), implying that the RIAs were monospecific and sensitive. The concentration of CgA in different tissues varied with the assay used. Hence, in a carcinoid tumor the concentration varied from 0.5 to 34.0 nmol/g tissue depending on the specificity of the CgA assay. The lowest concentration in all tumors was measured with the assay specific for the NH2 terminus of CgA. This is consistent with the relatively low concentrations measured in plasma from carcinoid tumor patients by the N-terminal assay, whereas the assays using antisera raised against CgA(210-222) and CgA(340-348) measured increased concentrations. CONCLUSION: Only some CgA assays appear useful for diagnosis of neuroendocrine tumors, but the entire library is valuable for studies of the expression and processing of human CgA.  (+info)

Serum gastrin and chromogranin A during medium- and long-term acid suppressive therapy: a case-control study. (5/561)

BACKGROUND: Serum chromogranin A (CgA) is regarded as a reliable marker of neuroendocrine proliferation. We previously described increased serum CgA levels during short-term profound gastric acid inhibition. AIM: To investigate serum gastrin and CgA levels in dyspeptic patients during continuous medium- (6 weeks to 1 year), or long-term (1-8 years) gastric acid suppressive therapy. PATIENTS AND METHODS: 114 consecutive dyspeptic patients referred for upper gastrointestinal endoscopy were enrolled in a cross-sectional, case-control study [62 patients on continuous antisecretory therapy, either with proton pump inhibitors (n = 47) or H2-receptor antagonists (H2RA) (n = 15) for gastro-oesophageal reflux disease with or without Barrett's oesophagus or functional dyspepsia, and 52 age- and sex-matched patients without medical acid inhibition and with normal endoscopic findings (control group)]. Omeprazole doses ranged from 20 mg to 80 mg daily and ranitidine from 150 mg to 450 mg daily. Fasting serum CgA and serum gastrin levels were measured by radioimmunoassay (reference values: serum CgA < 4.0 nmol/L; serum gastrin < 85 ng/L). RESULTS: Fasting serum CgA levels positively correlated with serum gastrin in the entire study population (r = 0. 55, P = 0.0001). Median serum CgA values were higher in patients treated with a proton pump inhibitor than H2RA [2.8 (2.0-5.9) nmol/L vs. 2 (1.9-2.3) nmol/L, P < 0.002] and controls [2.8 (2.0-5.9) nmol/L vs. 1.8 (1.5-2.2) nmol/L, P < 0.0001) and did not differ between patients treated with H2RA or controls. Serum gastrin and CgA levels in patients on proton pump inhibitor therapy positively correlated with the degree and duration of acid inhibition. Patients on long-term proton pump inhibitor therapy had significantly higher fasting serum gastrin and CgA than those on medium-term proton pump inhibitor therapy [127 (73-217) ng/L vs. 49 (29-78) ng/L, P < 0.0001 and 4.8 (2.8-8) ng/L vs. 2.1 (1.9-2.6) ng/L, P < 0.001]. No such relation was found in patients on medium- vs. long-term H2RA. Overall, patients with positive Helicobacter pylori serology had higher serum gastrin and CgA levels than those with negative H. pylori serology [51 (27-119) ng/L vs. 27 (14-79) ng/L, P = 0.01, 2.4 (1.9-3.4) nmol/L vs. 2.0 (1.7-2.5) nmol/L, P = 0.05]. CONCLUSIONS: During long-term continuous proton pump inhibitor treatment, serum gastrin and CgA levels are significantly elevated compared to H2RA treatment and nontreated dyspeptic controls. H. pylori infection seems to affect gastric ECL cell secretory function. Increased serum CgA values during long-term profound gastric acid inhibition could reflect either gastric enterochromaffin-like cell hyperfunction or proliferative changes.  (+info)

Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats. (6/561)

Dimethylbenzanthracene (DMBA) induces pancreatic adenocarcinomas in rats 9 months after carcinogen exposure, with precursor lesions (tubular complexes) developing 1 month after initiation of treatment. Because previous studies have suggested an acinar cell of origin for these tumors, we investigated the expression pattern of ductal, acinar, and islet cell markers in these cancers to gain insight into their phenotype and cell of origin. Pancreatic neoplasms were induced in rats by implantation of DMBA into the head of the pancreas. Lesions studied included 10 early tubular complexes (DMBA for 2 weeks), 8 tubular complexes (DMBA for 1 month), and 10 adenocarcinomas (DMBA for 9 months). Normal rat pancreas served as a control. For comparison, 5 human ductal adenocarcinomas were also evaluated. Immunohistochemistry with ductal (keratin, cytokeratin 19, cytokeratin 20), acinar (chymotrypsin), and islet (chromogranin A) cell markers was performed to analyze the tissues. Rat tubular complexes and adenocarcinomas revealed strong expression of keratin, cytokeratin 19, and cytokeratin 20 in the cytoplasm of all neoplastic cells, absence of chymotrypsin, and rare immunoreactivity to chromogranin A. Human adenocarcinomas showed strong expression of keratin and cytokeratin 19 in all neoplastic cells, expression of cytokeratin 20 in 5-20% of cells, and absence of chymotrypsin and chromogranin A. Pancreatic adenocarcinomas induced by DMBA in rats express markers consistent with a ductal phenotype, as observed in human tumors. Ductal marker expression in early tumor stages suggests a ductal cell of origin.  (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (7/561)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important.  (+info)

A new human chromogranin A (CgA) immunoradiometric assay involving monoclonal antibodies raised against the unprocessed central domain (145-245). (8/561)

Chromogranin A (CgA), a major protein of chromaffin granules, has been described as a potential marker for neuroendocrine tumours. Because of an extensive proteolysis which leads to a large heterogeneity of circulating fragments, its presence in blood has been assessed in most cases either by competitive immunoassays or with polyclonal antibodies. In the present study, 24 monoclonal antibodies were raised against native or recombinant human CgA. Their mapping with proteolytic peptides showed that they defined eight distinct epitopic groups which spanned two-thirds of the C-terminal part of human CgA. All monoclonal antibodies were tested by pair and compared with a reference radioimmunoassay (RIA) involving CGS06, one of the monoclonal antibodies against the 198-245 sequence. It appears that CgA C-terminal end seems to be highly affected by proteolysis and the association of C-terminal and median-part monoclonal antibodies is inadequate for total CgA assessment. Our new immunoradiometric assay involves two monoclonal antibodies, whose contiguous epitopes lie within the median 145-245 sequence. This assay allows a sensitive detection of total human CgA and correlates well with RIA because dibasic cleavage sites present in the central domain do not seem to be affected by degradation. It has been proved to be efficient in measuring CgA levels in patients with neuroendocrine tumours.  (+info)

Catecholamine release-inhibitory peptide catestatin (chromogranin A352-372) : Naturally occurring amino acid variant Gly364Ser...Catecholamine release-inhibitory peptide catestatin (chromogranin A352-372) : Naturally occurring amino acid variant Gly364Ser...
BACKGROUND - Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. We identified a natural nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and blood pressure. METHODS AND RESULTS - Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. Case-control studies replicated effects of the gene on blood pressure in the population. Gly364Ser displayed diminished inhibition of catecholamine secretion from cultured neurons. Gly/Ser heterozygotes displayed increased baroreceptor slope during upward deflections (by ≈47%) and downward deflections (by ≈44%), increased cardiac parasympathetic index (by ≈2.4-fold), and decreased cardiac sympathetic index (by ≈26%). Renal norepinephrine excretion was diminished by ≈26% and epinephrine excretion by ≈34% in Gly/Ser ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:43728
Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | CirculationCatecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A352-372) | Circulation
Heritable autonomic traits may be of particular value in investigations of the genetic underpinnings of hypertension, a complex trait with both hereditary and environmental determinants and likely even multiple genetic (or polygenic) determinants.7,8 Human twin studies indicate that baroreceptor activity is a substantially heritable trait.33 Such traits may be valuable intermediate phenotypes7,8 for hypertension, especially if they display earlier penetrance than the ultimate disease trait (DBP), can be elicited in still-normotensive individuals, and suggest testable candidate genetic loci (such as CHGA). Catestatin itself may be such a phenotype.8 Several of the autonomic phenotypes studied here (Table II and Figures 2 and 3⇑) meet these criteria.. Indeed, Gly364Ser genotypes were associated with hypertension (Figure 4a and 4b), especially in men (Figure 4b). Thus, the 364Ser allele may play a protective role against future the development of hypertension.. How might this happen? Because ...
http://circ.ahajournals.org/content/115/17/2271
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated...
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion Academic Article ...
http://vivo.med.cornell.edu/display/pubid53949122279
Chromogranin A. Storage and release in hypertension. | HypertensionChromogranin A. Storage and release in hypertension. | Hypertension
The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. Although the precise function of the chromogranins remains elusive, knowledge of their structure, distribution, and potential intracellular and extracellular roles, especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. Thus, measurement of its circulating concentration by radioimmunoassay may be a useful probe of exocytotic sympathoadrenal activity in humans, under both physiological and pathological conditions. Here, we explore the storage, structure, and function of chromogranin A, and parameters that influence its circulating levels. We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. ...
http://hyper.ahajournals.org/content/15/3/237
Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas<...Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas<...
TY - JOUR. T1 - Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas. AU - Oda, K.. AU - Inada, K.. AU - Osamura, R. Y.. PY - 1991. Y1 - 1991. N2 - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.. AB - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S ...
https://pure.fujita-hu.ac.jp/en/publications/immunohistochemical-studies-of-chromogranins-a-and-c-in-pituitary
Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific...Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/11257446?dopt=Abstract
The bovine chromogranin A gene: structural basis for hormone regulation and generation of biologically active peptides. -...The bovine chromogranin A gene: structural basis for hormone regulation and generation of biologically active peptides. -...
The structure of the gene encoding bovine chromogranin-A has been determined by characterization of two isolated genomic clones. Chromogranin-A is encoded by eight exons, which organize the coding region into several distinct structural and functional domains. Exons 1-5 represent the highly conserved signal peptide and N-terminal domain, which are separated into regions corresponding to the signal peptide, N-terminal sequence, disulfide-bonded loop, and remainder of the conserved N-terminal domain. Exon 6 represents the variable domain and encodes a region that is identical to the novel chromogranin-A-derived peptide chromostatin. Exon 7 encodes the biologically active peptide pancreastatin as well as most of the conserved C-terminal domain, with the remainder found on exon 8. The mRNA sequence obtained from the gene contains five nucleotide differences from the consensus sequence of four reported bovine chromogranin-A cDNA clones. Two of the differences in the gene result in two amino acid changes in
https://www.semanticscholar.org/paper/The-bovine-chromogranin-A-gene%3A-structural-basis-f-Iacangelo-Grimes/4fa7f0da6decd29db0689310dae28cbc88e176f1
Chromogranin A: Reference Range, Interpretation, Collection and PanelsChromogranin A: Reference Range, Interpretation, Collection and Panels
Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II.
https://emedicine.medscape.com/article/2114314-overview
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone SPM553 ] IHC...Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone SPM553 ] IHC...
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone SPM553 ] validated in IHC-P, IF, FC (AH10405-100), Abgent
http://www.abgent.com/products/AH10405-Chromogranin-A--CHGA-Neuroendocrine-Marker-Antibody-Without-BSA-and-Azide
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, IF,...Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide - Purified Mouse Monoclonal Antibody WB, IHC, IF,...
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, IF, FC, IP (AH10256-20), Abgent
http://www.abgent.com/products/AH10256-Chromogranin-A-Antibody-Clone-LK2H10--PHE5--CGA414
2018 AACC2018 AACC
Epitope Diagnostics EDI Human Chromogranin A ELISA Kit was recently used by a research group lead by Dr. Ugo De Giorgi to publish two key papers highlighting another aspect of the relationship between chromogranin A (CgA) and prostate cancer.. The two papers, published by Conteduca et al and Burgio et al, examined patients with castration-resistant prostate cancer (CRPC) who had received previous docetaxel chemotherapy treatment. Using the range established by the EDI Chromogranin A ELISA Kit, the patients were divided into three groups based on baseline CgA levels: normal CgA (,120 ug/ml), under 3 time normal (,360 ug/ml), and above 3 time normal (,360 ug/ml).. Prostate specific antigen was then monitored as the patients received antiandrogen treatment, either with abiraterone or enzalutamide, in order to track the progression free survival.. In the group treated with abiraterone, a statistically significant difference was discovered between the median progression free survival rate of those ...
https://events.jspargo.com/aacc18/Public/eBooth.aspx?BoothID=601016&Task=PressReleases&SSID=1765
Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. | PassportGlycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis. | Passport
Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function.. ...
https://passport.as.uky.edu/glycosylated-chromogranin-heart-failure-implications-processing-and-cardiomyocyte-calcium
Correlation between age and Chromogranin A determination in prostate diseases | IRIS Università degli Studi di Perugia
ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to evaluate the impact of age on CgA diagnostic significance. Materials and Methods: Serum levels of CgA were determinated in 217 consecutive patients immediately before prostate biopsy: CgA differences between cases (prostate cancer PC) and control (benign prostatic hyperplasia BPH) were analyzed, and CgA performance in prediction of PC was compared with age and standard diagnostic tools. CgA values were also analyzed in patients affected by PC, and compared with age and standard prognostic parameters. Results: At multivariate analysis, CgA approaches a statistically significant value as independent predictor of PC and positively correlates with age. In PC group, CgA positively correlates with age, while no correlations are found with PSA, Gleason score or stage of disease. Conclusions: Age, correlating with CgA values in overall population and in PC subgroup, emerged as a ...
https://research.unipg.it/handle/11391/923474
Evaluation of psychosomatic stress in children by measuring salivary chromogranin A. - PubMed - NCBIEvaluation of psychosomatic stress in children by measuring salivary chromogranin A. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/16882565?dopt=Abstract
Plus itPlus it
The mitogen-activated protein kinase (MAPK) pathway plays a pivotal role in intracellular signaling, and this cascade may impinge on cAMP response elements (CREs) of target genes. Both the MAPK pathway and chromogranin A expression may be activated by cytosolic calcium influx, and calcium-dependent signals map onto the chromogranin A promoter proximal CRE. We therefore probed the role of the MAPK pathway in chromogranin A biosynthesis after secretory stimulation of PC12 pheochromocytoma cells by the nicotinic cholinergic pathway, the physiological secretory trigger. Chemical inhibition of either MAPK or MAPK kinase blocked the response of a transfected chromogranin A promoter to nicotine or protein kinase C activation [by phorbol-12-myristate-13-acetate (PMA)], although nicotine-evoked catecholamine secretion was unaffected. Activation of the MAP kinase cascade (Ras, Raf, MAPK, or CREB kinase) by cotransfection of pathway components stimulated the chromogranin A promoter. Cotransfection of MAPK ...
https://molpharm.aspetjournals.org/content/54/1/59
Serpinin in the rat eye | IOVS | ARVO JournalsSerpinin in the rat eye | IOVS | ARVO Journals
Purpose: To investigate the distribution of the novel chromogranin A-derived neuropeptide serpinin in the rat eye.. Methods: The molecular form of serpinin-immunoreactivity detected by a highly specific antiserum was evaluated both by western blot analysis and reversed phase-HPLC with subsequent ELISA in the rat trigeminal ganglion (TG) and retina and the presence and distribution of the peptide was explored in the rat TG and eye by immunofluorescence.. Results: There was no band in western blots in the rat TG but two weak bands at 30 and 50 kDa in the retina. Only free serpinin but no (pGlu)-serpinin and no serpinin-RRG were detected by RP-HPLC in the rat TG and retina. Numerous small- and medium-sized cells contained serpinin-immunoreactivity in the rat TG and full colocalization with substance P was evident with a more widespread expression of serpinin. Immunoreactivity was present in nerves in the corneal, limbal, irideal, ciliary and choroidal/scleral stroma, sphincter and dilator muscle ...
http://iovs.arvojournals.org/article.aspx?articleid=2331254
RefEx - Search Result
Pituitary secretory protein I, CgA, Chromogranin A precursor, SP-I, CGA, chromogranin A (CgA), CHGA, chromogranin A (parathyroid secretory protein 1 ...
http://refex.dbcls.jp/genelist.php?lang=en&db=human&roku_valid=1&rk%5B%5D=35&order_key=score&pageID=2
Chromogranin A antibody [SPM585] | IDH Inhibitor idhinhibitor.com
Product Name: Chromogranin A antibody Applications: IHC-PPredicted Target Size: Positive Controls: Form Supplied: LiquidConcentration: Purification: Ab purified
https://www.idhinhibitor.com/2017/11/27/Chromogranin_A_antibody_SPM585/
CHGA monoclonal antibody, clone CHGA/777 - (MAB14233) - Products - Abnova
Mouse monoclonal antibody raised against full length recombinant human CHGA. Recombinant protein corresponding to full length human CHGA. (MAB14233) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=MAB14233
Plus itPlus it
NE differentiation in pancreatic carcinomas has been reported in various studies using IHC (13, 14, 15) . However, the expression of PGP9.5 and its relation to other NE markers have not been studied in pancreatic cancer to date. In this study, CGA was used as a marker for NE differentiation because it has been demonstrated to be a well-characterized marker for NE differentiation (16) . We found that tumor cells immunoreactive to CGA monoclonal antibody accounted for ,1% of the tumor cell population. On the other hand, PGP9.5 was expressed in 26 of 69 (37.7%) pancreatic cancers. These results suggested that the expression of PGP9.5 in pancreatic cancer is independent of NE differentiation.. Subsequently, we investigated a possible correlation of PGP9.5 status with clinicopathological features. Although PGP9.5 expression was not associated with tumor histology or the extent of the tumor, pancreatic cancer patients with PGP9.5 expression had significantly shorter survival times than those without ...
http://clincancerres.aacrjournals.org/content/6/12/4764
Chromogranin A Antibody (SPM553) [DyLight 650] (NBP2-34795C): Novus BiologicalsChromogranin A Antibody (SPM553) [DyLight 650] (NBP2-34795C): Novus Biologicals
Mouse Monoclonal Anti-Chromogranin A Antibody (SPM553) [DyLight 650]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP. Tested Reactivity: Human. 100% Guaranteed.
https://www.novusbio.com/products/chromogranin-a-antibody-spm553_nbp2-34795c
Chromogranin A Antibody (PHE5) [Alexa Fluor® 700] (NBP2-34709AF700): Novus BiologicalsChromogranin A Antibody (PHE5) [Alexa Fluor® 700] (NBP2-34709AF700): Novus Biologicals
Mouse Monoclonal Anti-Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P. Tested Reactivity: Human, Primate, and more. 100% Guaranteed.
https://www.novusbio.com/products/chromogranin-a-antibody-phe5_nbp2-34709af700
Xenopus as a developmental model of neuroblastoma | Disease Models & MechanismsXenopus as a developmental model of neuroblastoma | Disease Models & Mechanisms
Neuroblastoma (NB) is a paediatric form of cancer derived from the sympathetic nervous system. Recent genome-wide sequencing data suggest that often NB does not have a clear genetic cause, leading the authors to hypothesize that NB results from aberrations of normal development. To test this hypothesis, Anna Philpotts group used a population of anteroventral noradrenergic (AVNA) cells from Xenopus embryos. These cells share several features with mammalian sympathetic neurons, including the expression of noradrenergic-associated genetic markers such as the achaete-scute complex-like 1 (Ascl1) gene, which encodes a transcriptional driver of neurogenesis. By comparing AVNA and NB cells, the authors found that, whereas Ascl1 is only transiently expressed in AVNA cells, it is aberrantly maintained in NB, where it is phosphorylated on multiple serine-proline sites. The authors then show that differentiation of AVNA cells is enhanced by dephosphorylated Ascl1. Moreover, this process is inhibited by ...
http://dmm.biologists.org/content/8/5/e0502
Plus itPlus it
Angiogenesis has been postulated to be critical for the pathogenesis of multiple myeloma (MM), a neoplastic disease characterized by abnormal proliferation of malignant plasma cells in the bone marrow (BM). Cleavage of the N- and C-terminal regions of circulating chromogranin A (CgA, CHGA), classically an anti-angiogenic protein, can activate latent anti- and pro-angiogenic sites, respectively. In this study, we investigated the distribution of CgA-derived polypeptides in MM patients and the subsequent implications for disease progression. We show that the ratio of pro-/anti-angiogenic forms of CgA is altered in MM patients compared with healthy subjects, and that this ratio is higher in BM plasma compared with peripheral plasma, suggesting enhanced local cleavage of the CgA C-terminal region. Enhanced cleavage correlated with increased VEGF and FGF2 BM plasma levels and BM microvascular density. Using the Vk*MYC mouse model of MM, we further demonstrate that exogenously administered CgA was ...
http://cancerres.aacrjournals.org/content/early/2016/02/10/0008-5472.CAN-15-1637
Chromogranin A+B | ALZFORUMChromogranin A+B | ALZFORUM
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
https://www.alzforum.org/antibodies/chromogranin-ab
Chromogranin A (5H7) | ALZFORUMChromogranin A (5H7) | ALZFORUM
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
https://www.alzforum.org/antibodies/chromogranin-5h7
Plus itPlus it
In development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but it is incompletely understood which dysregulated mechanisms cause SC overpopulation. Because neuroendocrine cell (NEC) and SC populations both reside in the SC niche at the normal crypt bottom, we hypothesized that i) NECs play a role in maintaining the SC population, and ii) changes in the NEC population contributes to SC overpopulation and altered epithelial: stromal interactions during tumorigenesis. Immunofluorescence mapping and flow cytometry were used to analyze SC niche structure and cell-cell interactions in normal and neoplastic colonic tissues from Caucasian and African-American patients. In normal colonic crypts, most cells (77%) staining positively for the colonic SC marker ALDH1, also co-stained for the NE cell marker chromogranin-A (CGA). In the progression from normal to normal-appearing FAP to adenomatous to malignant colonic tissue, the proportion of ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/4256
Akkrediteringsomfang | Norsk AkkrediteringAkkrediteringsomfang | Norsk Akkreditering
Farging immunhistokjemiske analyser (ER, Synaptophysin, Vimentin, E-cadherin (CDH1), CEA mono, Programmed death ligand 1 (PDL1), ALK D5F3, CD5, CD23, CD30, CD117, PAX8, PSA, S100, CD31, CD34, CDX2, CK5/6, CK20, CK-PAN (MNF116), CyclinD1, Desmin, Ki67, p40, SOX10, TTF1, Chromogranin A (CGA), Melan-A, HER-2 IHC, CK14, CD3, CD20, CD10, CK7, p16, p53, IgL - Kappa/ IgL - Lamda ...
https://akkreditert.no/akkrediterte-organisasjoner/akkrediteringsomfang/?AkkId=1005
NPHL :: Post
Immunohistochemistry, is a special staining process performed on tissue removed during biopsy. Immunohistochemistry for lung cancer represents an important complementary tool for the routine diagnosis of lung cancer and for the identification of the different histological types and prognostic factors. We offer panel of IHC markers: TTF 1, p63, Ck 7, Ck 5/6, Napsin, Chromogranin and Ck 20.. ...
http://nphl.gov.np/post/lung-cancerihc
Indications for the Chromagranin A Test: Why Doctors Use This TestIndications for the Chromagranin A Test: Why Doctors Use This Test
This article discusses the importance of testing for Chromogranin A levels in a variety of tumors, especially in the adrenal gland. Learn how this test works and what the results mean.
http://www.brighthub.com/science/medical/articles/43642.aspx
KillSorza -vs- skorpion ~(TD: 27,97 M)KillSorza -vs- skorpion ~(TD: 27,97 M)
Not the biggest profit for over 2k BCs but... This guy is in the same system as me so it took very little deut to fly, not to mention only under 15 minutes ther
http://ltlmembers.bigforumpro.com/t4660-killsorza-vs-skorpion-td-2797-m
KillSorza -vs- Narta ~(TD: 11,05 M)KillSorza -vs- Narta ~(TD: 11,05 M)
Ive been busy lately but I havent been inactive so I post the CRs that are days old. To be honest Im not particularly proud of this one because Ive sent th
http://ltlmembers.bigforumpro.com/t4684-killsorza-vs-narta-td-1105-m
配件 CO<sub>2</sub> Regulator, inlet fitting meets CGA...配件 CO<sub>2</sub> Regulator, inlet fitting meets CGA...
BioTek Product Accessory, Part Number: 1210514, for use with Lionheart FX自動化活細胞影像系統 and Cytation 5 自動化影像系統暨多功能光學檢測儀
https://www.biotek.tw/zh-TW/products/accessories/co2-regulator-inlet-fitting-meets-cga-320-standard/
Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin BAutonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B
Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:317372
Chromogranin A: Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland<...Chromogranin A: Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland<...
TY - JOUR. T1 - Chromogranin A. T2 - Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland. AU - Helle, K. B.. AU - Marley, P. D.. AU - Angeletti, R. H.. AU - Aunis, D.. AU - Galindo, E.. AU - Small, D. H.. AU - Livett, B. G.. PY - 1993. Y1 - 1993. N2 - Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-secreted with adrenaline and noradrenaline in the adrenal medulla. A number of biologically active fragments of CGA (CGAFs) have been characterized including a group of small N-terminal fragments collectively named vasostatins due to their vascular inhibitory activity. In the present study, the release of CGAFs, including CGA N-terminal fragments, from the isolated, retrogradely perfused bovine adrenal gland, has been studied under basal conditions and during nerve stimulation and perfusion with acetylcholine. The CGAFs were characterized by SDS-PAGE followed by immunoblotting with antisera to specific sequences within ...
https://einstein.pure.elsevier.com/en/publications/chromogranin-a-secretion-of-processed-products-from-the-stimulate-2
Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic...Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic...
PRIMARY OBJECTIVES:. l. To assess the progression-free survival rate of patients with locally advanced or metastatic pancreatic neuroendocrine tumors treated with everolimus alone or everolimus plus bevacizumab.. SECONDARY OBJECTIVES:. I. To compare progression-free survival (PFS) among treatment arms shown to be efficacious.. II. To estimate the overall tumor response rate in patients with metastatic pancreatic neuroendocrine tumors treated with one of two novel regimens.. III. To estimate the overall biochemical response rate (as measured by plasma chromogranin A levels) in patients with metastatic pancreatic neuroendocrine tumors treated with these regimens.. IV. To assess the toxicity of each regimen in patients with metastatic pancreatic neuroendocrine tumors.. V. To assess the overall survival of patients with pancreatic neuroendocrine tumors treated with these regimens.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive everolimus orally (PO) once daily ...
https://clinicaltrials.gov/ct2/show/study/NCT01229943?cond=%22Adenoma%22&intr=%22Octreotide%22&rank=10&view=results
An Isolated Abnormal Chromogranin B Is Associated with Pancreato-Duodenal NETs and the Presence of Liver Metastases
Introduction: Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). CgA assays may have different sensitivities, which is of importance for the clinical diagnosis and handling of NET patients ...
https://www.enets.org/an-isolated-abnormal-chromogranin-b-is-associated-with-pancreato-duodenal-nets-and-the-presence-of-liver-metastases.html
OriGene - CHGB (NM 001819) Human ORF cDNA CloneOriGene - CHGB (NM 001819) Human ORF cDNA Clone
CHGB - CHGB (Myc-DDK-tagged)-Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_001819/RC201744/CHGB.aspx
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel SyndromeDuodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
|i|Background and Aim|/i|. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). |i|Methods|/i|. The present study was undertaken to evaluate the density of duodenal CgA as a biomarker for the diagnosis of IBS. Two hundred and three patients with IBS were recruited (180 females and 23 males; mean age, 36 years; range, 18–66 years). The control group comprised 86 healthy subjects without gastrointestinal complaints (77 females and 9 males; mean age, 38 years; range, 18–67 years). Biopsy samples were taken from the duodenum during gastroscopy. Sections from these biopsy samples were immunostained for CgA using the avidin-biotin complex (ABC) method. CgA cell density was quantified by computerized image analysis. |i|Results|/i|. The CgA cell density was lower in IBS-total and in all of the IBS subgroups than in the controls. The sensitivity and specificity for a cutoff of <200 
https://www.hindawi.com/journals/grp/2014/462856/
Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A - Fingerprint -...Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A - Fingerprint -...
Fingerprint Dive into the research topics of Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A. Together they form a unique fingerprint. ...
https://einstein.pure.elsevier.com/en/publications/chromaffin-granule-and-pc12-cell-chondroitin-sulfate-proteoglycan-2/fingerprints/
Neuroendocrine differentiation in a case of cervical cancerNeuroendocrine differentiation in a case of cervical cancer
Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance
http://www.panafrican-med-journal.com/content/article/6/4/full/
SSAT - 2007 Abstracts: Suberoylanilide Aydroxamic Acid (Saha) Activates Notch1 Signaling and Inhibits Proliferation By Inducing...
Results: SAHA treatment of BON and H727 carcinoid tumor cells resulted in increased expression of acetylated histone 4, indicating HDAC inhibition. Furthermore, SAHA treatment led to a dose-dependent induction of the neuroendocrine signaling protein Notch1 in both its full-length and active, cleaved forms. Achaete-scute complex-like 1 (ASCL1), a downstream target of Notch1 signaling known to regulate the neuroendocrine phenotype, was suppressed by SAHA. Carcinoid tumor cell proliferation was inhibited by the drug in a dose-dependent manner. The mechanism of growth inhibition was G1 cell cycle arrest, as evidenced by increased protein levels of p21 and p27, and suppression of cyclin D1, in SAHA-treated cells ...
https://meetings.ssat.com/abstracts/07ddw/SSAT-DDW07-42.cgi
Complex Renal Traits: Role of Adrenergic Genetic Polymorphism | American Society of NephrologyComplex Renal Traits: Role of Adrenergic Genetic Polymorphism | American Society of Nephrology
Many if not most of the common disease states encountered in internal medicine, nephrology in particular, are complex traits1: Typically poorly understood and likely to be multifactorial, with etiologic contributions from both heredity and environment. Family or twin studies can establish the relative roles of heredity or environment trait determination, and indeed, familial aggregation or heritability is documented for such traits as hypertension2 and chronic kidney disease,3 whereas less common traits, including adult and juvenile polycystic kidney disease, display simpler, Mendelian hereditary patterns. The contribution of polymorphisms at specific loci are now documented for hypertensive ESRD, including the nonmuscle myosin variant, MYH9,4 and the catecholamine storage vesicle protein chromogranin A, CHGA.5 Systematic family studies have not been conducted in acute kidney injury (AKI), perhaps because of the transient nature of the illness coupled with unavailability of appropriate ...
https://jasn.asnjournals.org/content/20/6/1172
Environmental Influence on Holistic Health Measures - NUNM Helfgott Research InstituteEnvironmental Influence on Holistic Health Measures - NUNM Helfgott Research Institute
Principal Investigator: Kurt Beil, ND, LAc, MPH. This study examines the effects of different environmental settings on objective and subjective measures of physical and mental well-being. Participants (n=30) are taken for one hour per week to one of three different environmental settings: 1) Forested nature park, 2) Urban built plaza, and 3) Indoor windowless auditorium. One setting is visited per week, for three successive weeks; the setting visitation order is randomized individually. Participants are asked to sit quietly in each setting and observe their surroundings while data is collected.. Primary outcome measures (salivary Cortisol, Alpha-amylase & Immunoglobulin AA) are collected pre- and post-environmental setting exposure. Secondary outcome measures include pre- and post-exposure affective (POMS, SVS) and cognitive (DSB) questionnaires. Exploratory measures (i.e. salivary Chromogranin A) are also collected pre- and post-exposure. Potential co-factors including environmental identity ...
https://helfgott.nunm.edu/projects/mind-body-medicine/environmental-settings-health-effects/
Losec MUPS 10mg Gastro-resistant Tablets | Medicines.ieLosec MUPS 10mg Gastro-resistant Tablets | Medicines.ie
Section 4.4. New Paragraph inserted after Paragraph 4. Interference with laboratory tests. Increased CgA level may interfere with investigations for neuroendocrine tumours. To avoid this interference the omeprazole treatment should be temporarily stopped five days before CgA measurements. Section 5.1 Other effects related to acid inhibition Paragraph 3 amended to:. Chromogranin A (CgA) also increases due to decreased gastric acidity. This CgA modifying effect can not be demonstrated five days after stopping treatment with PPIs. Section 10. Date of revision changed to 20th January 2012. ...
https://www.medicines.ie/medicines/losec-mups-10mg-gastro-resistant-tablets-32738
CHGB Gene - GeneCards | SCG1 Protein | SCG1 AntibodyCHGB Gene - GeneCards | SCG1 Protein | SCG1 Antibody
Complete information for CHGB gene (Protein Coding), Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CHGB
CHGA Gene - GeneCards | CMGA Protein | CMGA AntibodyCHGA Gene - GeneCards | CMGA Protein | CMGA Antibody
Complete information for CHGA gene (Protein Coding), Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=1113
I feel flu-like CONSTANTLY - I cannot get a diagnosis. - Condition | Our HealthI feel flu-like CONSTANTLY - I cannot get a diagnosis. - Condition | Our Health
I think you have a few issues 1) Gut wise you need make sure you have IBS - if not already I would recommend a endoscopy of both ends - especially colon - you may have an adenoma, or celliacs or ulcers making you feel unwell. So I would get this sorted to see if there is any pathology causing your IBS symptoms - if there is a reason for this you could be treated and you could be 100% better. 2) you have a lot of pain - I would see a neurologist to work you up. I would get some MRI imaging done of your brain, neck and spine. I would also get a bone scan done to see if this is clear. 3) The rib pain - I would get a simple chest x-ray to show this is clear. 4) Some blood tests - do a full blood count, iron studies, liver function, electrolytes, renal function, PTH, Vit D, Corrected Calcium, B12, folate, ACE, CEA, Chromogranin A, HCG, Cortisol, Testosterone, LH, FSH, also your cholesterol and lipid profile, CRP, ESR. It is not good to be negative - make sure your health comes first - follow-up with ...
http://www.ourhealth.com/conditions/i-cannot-get-a-diagnosis/i-feel-flu-like-constantly
VS-2EQH01HM3, VS-2EQH02HM3 Ultrafast Rectifier, 2 A FRED Pt | VishayVS-2EQH01HM3, VS-2EQH02HM3 Ultrafast Rectifier, 2 A FRED Pt | Vishay
VS-2EQH01HM3, VS-2EQH02HM3 Ultrafast Rectifier, 2 A FRED Pt , available from Vishay Intertechnology, a global manufacturer of electronic components.
https://www.vishay.com/ppg?96564
VS-10RIA Series Medium Power Phase Control Thyristors (Stud Version), 10 A | VishayVS-10RIA Series Medium Power Phase Control Thyristors (Stud Version), 10 A | Vishay
VS-10RIA Series Medium Power Phase Control Thyristors (Stud Version), 10 A, available from Vishay Intertechnology, a global manufacturer of electronic components.
https://www.vishay.com/thyristors/list/product-93689/
3M™ CeQUINBORD CGA Inorganic Insulating Board | 3M United States3M™ CeQUINBORD CGA Inorganic Insulating Board | 3M United States
3M™ CeQUINBORD CGA Inorganic Insulating Board provides excellent thermal stability and long term voltage endurance for dry-type transformers in applications such as core tubes, spacers, end fills and ground insulation. Available from 1/32%22 to 1/8%22 (.79 to 3.2mm) thickness, CeQUINBORD CGA board is a cost-effective solution for major insulation applications rated through Class 220(R).
https://www.3m.com/3M/en_US/company-us/all-3m-products/~/3M-CeQUINBORD-CGA-Inorganic-Insulating-Board/?N=5002385+8709319+8745513+3293717941&rt=rud
SCG5SCG5
Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. ... Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic ...
https://en.wikipedia.org/wiki/SCG5
SCG3SCG3
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... "Entrez Gene: SCG3 secretogranin III". Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) ... "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of ...
https://en.wikipedia.org/wiki/SCG3
GraninGranin
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of ...
https://en.wikipedia.org/wiki/Granin
SCG2SCG2
2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human ... Chromogranin Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... 2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1-3): 13-21. doi:10.1016/j.regpep.2008.07. ...
https://en.wikipedia.org/wiki/SCG2
PheochromocytomaPheochromocytoma
If metanephrine values are equivocal, chromogranin A can be used as an adjunct marker to predict the presence of a tumor.[ ... Other additional biomarkers can be helpful to aid in the diagnosis of pheochromocytoma as well, most notable is Chromogranin A ... d'Herbomez M, Do Cao C, Vezzosi D, Borzon-Chasot F, Baudin E (September 2010). "Chromogranin A assay in clinical practice". ... However, a 2006 report from Italy found that over 90% of studied pheochromocytoma patients demonstrated elevated chromogranin A ...
https://en.wikipedia.org/wiki/Pheochromocytoma
Carcinoid syndromeCarcinoid syndrome
Chromogranin A and platelets serotonin are increased.[clarification needed] Transthoracic echocardiogram shows valve thickening ... Nobels FR, Kwekkeboom DJ, Bouillon R, Lamberts SW (June 1998). "Chromogranin A: its clinical value as marker of neuroendocrine ... Markers of the condition such as chromogranin-A are imperfect indicators of disease progression. Prognosis varies from ...
https://en.wikipedia.org/wiki/Carcinoid_syndrome
Solid pseudopapillary tumourSolid pseudopapillary tumour
... they are negative for chromogranin and pancreatic enzymes. The gold standard for diagnosing solid pseudopapillary tumour of the ...
https://en.wikipedia.org/wiki/Solid_pseudopapillary_tumour
Ceruminous adenomaCeruminous adenoma
The cells are negative with chromogranin, synaptophysin and CK20. The major diagnosis from which to separate ceruminous adenoma ...
https://en.wikipedia.org/wiki/Ceruminous_adenoma
Saliva testingSaliva testing
Soell M, Feki A, Hannig M, Sano H, Pinget M, Selimovic D (February 2010). "Chromogranin A detection in saliva of type 2 ... chromogranin A) was over-expressed in 100% of diabetic patients when compared to controls. In 2010 Qvarnstrom, et al., ...
https://en.wikipedia.org/wiki/Saliva_testing
Thyroid neoplasmThyroid neoplasm
Intrathyroidal parathyroid adenoma expressing chromogranin A (f) and PTH (g). Calcitonin-negative medullary thyroid carcinoma ( ...
https://en.wikipedia.org/wiki/Thyroid_neoplasm
Peptide YYPeptide YY
"Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells". ...
https://en.wikipedia.org/wiki/Peptide_YY
SecretoneurinSecretoneurin
Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is cleaved into the ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...
https://en.wikipedia.org/wiki/Secretoneurin
HomeostasisHomeostasis
Koeslag, Johan H.; Saunders, Peter T.; Wessels, Jabus A. (1999). "The chromogranins and counter-regulatory hormones: do they ...
https://en.wikipedia.org/wiki/Homeostasis
Neuroendocrine tumorNeuroendocrine tumor
Aside from the hormones of secretory tumors, the most important markers are: chromogranin A (CgA), present in 99% of metastatic ... Neuroendocrine secretory protein-55, a member of the chromogranin family, is seen in pancreatic endocrine tumors but not ... Widely used neuroendocrine tissue markers are various chromogranins, synaptophysin and PGP9.5. Neuron-specific enolase (NSE) is ... chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated. Functional tumors are ...
https://en.wikipedia.org/wiki/Neuroendocrine_tumor
InsulinomaInsulinoma
Pancreatic insulinoma Pancreatic insulinoma Chromogranin A Insulin immuostain Causes of hypoglycemia Metastatic Insulinoma ...
https://en.wikipedia.org/wiki/Insulinoma
Lung cancerLung cancer
... or chromogranin. Around 10% of lung cancers are rarer types rather than the classical four. These include mixes of the above ...
https://en.wikipedia.org/wiki/Lung_cancer
Secretogranin-1Secretogranin-1
... , also known as Chromogranin B, is a protein that in humans is encoded by the CHGB gene. It is a member of the ...
https://en.wikipedia.org/wiki/Secretogranin-1
B3GAT1B3GAT1
Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal ... conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin ...
https://en.wikipedia.org/wiki/B3GAT1
MIA PaCa-2MIA PaCa-2
... chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56. The cells have a round, epithelial morphology, and are adherent ...
https://en.wikipedia.org/wiki/MIA_PaCa-2
MepartricinMepartricin
Fan S, Hao ZY, Zhang L, Chen XG, Zhou J, Zang YF, Tai S, Liang CZ (2014). "Increased chromogranin A and neuron-specific enolase ...
https://en.wikipedia.org/wiki/Mepartricin
Pancreatic neuroendocrine tumorPancreatic neuroendocrine tumor
... chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. In total, 85% of ... immunohistochemistry is generally positive for chromogranin and synaptophysin. Genetic testing thereof typically shows altered ...
https://en.wikipedia.org/wiki/Pancreatic_neuroendocrine_tumor
SynaptophysinSynaptophysin
Diagnostically, it is often used in combination with chromogranin A. List of human genes Synaptophysin has been shown to ...
https://en.wikipedia.org/wiki/Synaptophysin
Molecular diagnosticsMolecular diagnostics
"Selective localization of the parathyroid secretory protein-I/adrenal medulla chromogranin A protein family in a wide variety ...
https://en.wikipedia.org/wiki/Molecular_diagnostics
Zollinger-Ellison syndromeZollinger-Ellison syndrome
An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...
https://en.wikipedia.org/wiki/Zollinger–Ellison_syndrome
Neuroendocrine differentiationNeuroendocrine differentiation
Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely ... chromogranin A (CgA), synaptophysin and neuron-specific enolase (NSE) (three proteins that are used as markers for ... chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or ...
https://en.wikipedia.org/wiki/Neuroendocrine_differentiation
ParagangliomaParaganglioma
... the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron specific enolase, serotonin, ...
https://en.wikipedia.org/wiki/Paraganglioma
Neuroendocrine cellNeuroendocrine cell
... chromogranin A, gastrin-releasing peptide (GRP), and cholecystokinin. These cells can be the source of several types of lung ...
https://en.wikipedia.org/wiki/Neuroendocrine_cell
XeninXenin
... is a peptide hormone secreted from the chromogranin A-positive enteroendocrine cells called the K-cells in the mucous ...
https://en.wikipedia.org/wiki/Xenin
Multiple endocrine neoplasia type 1Multiple endocrine neoplasia type 1
Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's ...
https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_1
Papillary carcinomas of the breastPapillary carcinomas of the breast
... and chromogranin A and chromogranin B encoded respectively by the CHGA and CHGB genes. The best treatments for SPC have not ...
https://en.wikipedia.org/wiki/Papillary_carcinomas_of_the_breast
Anti-Chromogranin A antibody (ab45179) | AbcamAnti-Chromogranin A antibody (ab45179) | Abcam
Rabbit polyclonal Chromogranin A antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 20 ... Anti-Chromogranin A antibody (ab45179) at 1/1000 dilution (purified) + PC-12 cell lysate at 20 µg. Secondary. Goat Anti-Rabbit ... Anti-Chromogranin A antibody (ab45179) at 1/5000 dilution (purified) + SH-SY5Y cell lysate at 10 µg. Secondary. Goat Anti- ... Anti-Chromogranin A antibody (ab45179) at 1/10000 dilution (unpurified) + PC-12 cell lysate at 10 µg. Secondary. HRP-conjugated ...
https://www.abcam.com/chromogranin-a-antibody-ab45179.html
Circulating Gastrin and Chromogranin A: Elevated | GreenMedInfoCirculating Gastrin and Chromogranin A: Elevated | GreenMedInfo
Adverse Pharmacological Actions : Circulating Gastrin and Chromogranin A: Elevated, Tumor Marker Elevation: Chromogranin ... Circulating Gastrin and Chromogranin A: Elevated Related Articles. Medical Errors Kill Enough People to Fill 4 Jumbo Jets a ... 1 Abstracts with Circulating Gastrin and Chromogranin A: Elevated Research. Filter by Study Type. Human Study. ... 1 Problem Substances Researched for Circulating Gastrin and Chromogranin A: Elevated Name. AC. CK. Focus. ...
https://greenmedinfo.com/adverse-pharmacological-action/circulating-gastrin-and-chromogranin-elevated
CHGA Protein Human | Chromogranin A Recombinant | ProSpecCHGA Protein Human | Chromogranin A Recombinant | ProSpec
Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/ ... CHGA, CGA, Chromogranin-A, Vasostatin I, SP-I, Pituitary secretory protein I. ...
https://www.prospecbio.com/chromogranin_a
Chromogranin A in the mammalian heart - ResultatChromogranin A in the mammalian heart - Resultat
Chromogranin A in the mammalian heart: Expression without secretion. Publikation: Bidrag til tidsskrift › Letter › Forskning › ... Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. ...
https://forskning.ku.dk/soeg/result/?pure=da/publications/chromogranin-a-in-the-mammalian-heart
Chromogranin A - Biocare MedicalChromogranin A - Biocare Medical
Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological...Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological...
We report on a cohort of 1170 cases that synaptophysin, chromogranin and CD56 are commonly expressed in ADC and SqCC and that ... The least common positive marker was chromogranin. A combination of ≤2 neuroendocrine markers was positive in 2-3% of ADC and 0 ... All cases were stained with synaptophysin, chromogranin and CD56. Positivity was defined as > 1% positive tumor cells. Data ... Therefore, we investigated retrospectively a large cohort to expand the data on the role of synaptophysin, chromogranin and ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08140-9/tables/1
Chromogranin A Test Uk - Consortium for Post-Genome ScienceChromogranin A Test Uk - Consortium for Post-Genome Science
Chromogranin A Test Uk. Lab Reagents Chromogranin Assay Laboratories manufactures the chromogranin a test uk reagents ... please contact chromogranin assay. Other Chromogranin products are available in stock. Specificity: Chromogranin Category: A ... The Chromogranin A Test Uk reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase ...
https://www.postgenomeconsortium.com/chromogranin-a-test-uk/
An antibody against secretogranin I (chromogranin B) is packaged into secretory granules. | Journal of Cell Biology |...An antibody against secretogranin I (chromogranin B) is packaged into secretory granules. | Journal of Cell Biology |...
An antibody against secretogranin I (chromogranin B) is packaged into secretory granules. P Rosa, P Rosa ... P Rosa, U Weiss, R Pepperkok, W Ansorge, C Niehrs, E H Stelzer, W B Huttner; An antibody against secretogranin I (chromogranin ... An mAb against secretogranin I (chromogranin B), a secretory protein costored with various peptide hormones and neuropeptides ...
https://rupress.org/jcb/article/109/1/17/59262/An-antibody-against-secretogranin-I-chromogranin-B
Chromo Granin A - Metro Office Supply at J. Craig Venter InstituteChromo Granin A - Metro Office Supply at J. Craig Venter Institute
Chromo Granin A. Lab Reagents Chromagranin A Laboratories manufactures the chromo granin a reagents distributed by Genprice. ... The Chromo Granin A reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these ...
https://www.mymetroofficeproducts.net/chromo-granin-a/
CHROMOGRANIN IHC | Vijaya Medical CentreCHROMOGRANIN IHC | Vijaya Medical Centre
No. 14G, Chinagadili, Health City, Visakhapatnam 530 040, AP, India. [email protected] ...
https://vijayamedicalcentre.com/test/chromogranin-ihc/
Chromogranin Control Slides - CS155 - gccdiagnostics.com
Anti Human Chromogranin A Antibody | Bio-RadAnti Human Chromogranin A Antibody | Bio-Rad
... recognizes human chromogranin A, a secreted peptide that inhibits glucose-induced insulin release. Chromogranin A is an ... Sheep anti Human Chromogranin A. Product Type. Polyclonal Antibody. Isotype. Polyclonal IgG. Specificity. Chromogranin A. Quick ... Sheep anti Human Chromogranin antibodyrecognizes human chromogranin A, a secreted peptide that inhibits glucose-induced insulin ... Chromogranin A is an activator of microglia (Taupenaut et al. 1996) and is notably upregulated and prominantly expressed in the ...
https://www.bio-rad-antibodies.com/polyclonal/human-chromogranin-a-antibody-2095-0220.html
Enzyme-Linked Immunosorbent Assay for Chromogranin A - ILVOEnzyme-Linked Immunosorbent Assay for Chromogranin A - ILVO
Dillen L, De Block J, Van Laer L, De Potter W. Enzyme-Linked Immunosorbent Assay for Chromogranin A. Clinical Chemistry. 1989; ... Dillen, L., De Block, J., Van Laer, L., & De Potter, W. (1989). Enzyme-Linked Immunosorbent Assay for Chromogranin A. Clinical ... Dillen, L, De Block, J, Van Laer, L & De Potter, W 1989, Enzyme-Linked Immunosorbent Assay for Chromogranin A, Clinical ... Enzyme-Linked Immunosorbent Assay for Chromogranin A. / Dillen, Lieve; De Block, Jan; Van Laer, Lutgard ; De Potter, Werner. ...
https://pureportal.ilvo.be/nl/publications/enzyme-linked-immunosorbent-assay-for-chromogranin-a
Chromogranin A (CgA) - Ronny Allan - Living with Neuroendocrine CancerChromogranin A (CgA) - Ronny Allan - Living with Neuroendocrine Cancer
... which release chromogranin A and certain hormones into the blood. Chromogranin A may be found in higher than normal amounts in ... Chromogranin A is a type of tumour marker. Also called CgA. Also used in Immunostains where it is specific but not sensitive ... Measuring the amount of chromogranin A in the blood may help to diagnose cancer or other conditions or find out how well ... Tag: Chromogranin A (CgA). A protein found inside neuroendocrine cells, which release chromogranin A and certain hormones into ...
https://ronnyallan.net/tag/cga/
Serum chromogranin-A in hepatocellular carcinoma: diagnostic utility and limits.
... SPADARO, Aldo;AJELLO, Antonino;MORACE, ... High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions ... High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions ...
https://iris.unime.it/handle/11570/1890120
IMSEAR at SEARO: Salivary chromogranin A as a measure of stress response to noise.
Salivary chromogranin A as a measure of stress response to noise.. Authors: Miyakawa, Masamitsu. Matsui, Toshihito. Kishikawa, ... Miyakawa M, Matsui T, Kishikawa H, Murayama R, Uchiyama I, Itoh T, Yoshida T. Salivary chromogranin A as a measure of stress ... Effects of noise on the secretion of salivary chromogranin A (CgA), which is considered to be a substitute measure of ...
https://imsear.searo.who.int/handle/123456789/121991
Chromogranin 49 Ngl. Using The Cisbio Cga-Elisa-Us Kit. - Gel electrophoresisChromogranin 49 Ngl. Using The Cisbio Cga-Elisa-Us Kit. - Gel electrophoresis
... please contact chromogranin elisa. Other Chromogranin products are available in stock. Specificity: Chromogranin Category: 49 ... Chromogranin Elisa Laboratories manufactures the chromogranin 49 ngl. using the cisbio cga-elisa-us kit. reagents distributed ... The Chromogranin 49 Ngl. Using The Cisbio Cga-Elisa-Us Kit. reagent is RUO (Research Use Only) to test human serum or cell ... Description: Primary antibody against Chromogranin A(CGA414 + CGA/777 + CGA/798), CF660R conjugate, Concentration: 0.1mg/mL ...
https://electroforese.com/chromogranin-49-ngl-using-the-cisbio-cga-elisa-us-kit/
USCN life science : Producing ELISA kit, ELISA Kit for Guinea Pig Chromogranin A(CHGA)USCN life science : Producing ELISA kit, ELISA Kit for Guinea Pig Chromogranin A(CHGA)
Related article about: ELISA Kit for Guinea Pig Chromogranin A(CHGA) Other elisa kits Products ELISA Kit for Human Neurotrophic ...
http://uscnlifescience.com/product_description_of_ELISA%20Kit%20for%20Guinea%20Pig%20Chromogranin%20A
Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients - CROSBIChromogranin A as a marker of osteolysis in stage D3 prostate cancer patients - CROSBI
Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients}, keyword = {chromogranin A, osteolysis, prostate ... Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients}, keyword = {chromogranin A, osteolysis, prostate ... Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients // Anticancer Research, 24 (2004), 5D. (podatak o ... Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients // Anticancer Research, 24 (2004), 5D. (podatak o ...
https://www.bib.irb.hr/225650
Assisted reproductive technologies do not enhance the variability of DNA methylation imprints in humanAssisted reproductive technologies do not enhance the variability of DNA methylation imprints in human
Chromogranins * DLK1 protein, human * GRB10 protein, human * H19 long non-coding RNA ...
https://pubmed.ncbi.nlm.nih.gov/19948534/?dopt=Abstract
Mouse Transforming growth factor-beta-induced protein ig-h3 (TGFBI) ELISA kit | CSB-EL023450MO | CusabioMouse Transforming growth factor-beta-induced protein ig-h3 (TGFBI) ELISA kit | CSB-EL023450MO | Cusabio
Human Chromogranin, CgA ELISA Kit , CSB-E09153h , CusabioHuman Chromogranin, CgA ELISA Kit is Available at Gentaur Genprice ...
https://joplink.net/mouse-transforming-growth-factor-beta-induced-protein-ig-h3-tgfbi-elisa-kit-csb-el023450mo/
Carcinoid syndrome: MedlinePlus Medical EncyclopediaCarcinoid syndrome: MedlinePlus Medical Encyclopedia
Blood tests (including serotonin and chromogranin blood tests). *CTMRI scan of the chest or abdomen ...
https://medlineplus.gov/ency/article/000347.htm
Lung neuroendocrine tumors: A systematic literature review (Review)Lung neuroendocrine tumors: A systematic literature review (Review)
In general, LNETs are positive for chromogranin A, synaptophysin and CD56. However, in types of LNETs that have to be ... Immunologic markers used to differentiate NETs are chromogranin A, synaptophysin, CD56 and NSE. In order to discriminate ... Using this they observed that a low level of 5-HIAA and an increased serum chromogranin A represent an indicator of poor ... the most important tool is the serum dosing of chromogranin A in association with urinary dosing of 5 hydroxyindoleacetic acid ...
https://www.spandidos-publications.com/10.3892/etm.2021.11099?text=fulltext
Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA...
Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. In humans, normal ... Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. In humans, normal ... Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 ( ... Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 ( ...
https://iris.unisr.it/handle/20.500.11768/2965
Chromogranin mRNA levels in the brain as a marker for acute and chronic changes in neuronal activity: effect of treatments...
Chromogranin mRNA levels in the brain as a marker for acute and chronic changes in neuronal activity: effect of treatments ... Chromogranin/secretogranins are a family of acidic, soluble proteins with a widespread distribution in secretory vesicles of ... The effects of experimental stimuli of differing duration and intensity on chromogranin B and secretogranin II mRNA levels in ... Chromogranins.genetics. Genetic Markers. Male. Molecular Sequence Data. Nerve Tissue Proteins.genetics. Neurons.metabolism. ...
https://ahro.austin.org.au/austinjspui/handle/1/13449
Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen...Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen...
T1 - Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific ... Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen ... Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen ... Plasma chromogranin A in patients with prostate cancer improves the diagnostic efficacy of free/total prostate-specific antigen ...
https://publires.unicatt.it/it/publications/plasma-chromogranin-a-in-patients-with-prostate-cancer-improves-t
Clinical Chemistry and Laboratory Medicine (CCLM) Volume 36 Issue 11Clinical Chemistry and Laboratory Medicine (CCLM) Volume 36 Issue 11
Using chromogranin A at a cut-off level of 30.3 U/ml it was possible to discriminate between patients in remission and patients ... In our study that lasted over one year we could clearly show that the measurement of chromogranin A is impressively superior to ... Usefulness of Chromogranin A as a Marker for Detection of Relapses of Carcinoid Tumours ... It is well known that peptide-producing endocrine tumours cosecrete immunoreactive chromogranin A with their characteristic ...
https://www.degruyter.com/journal/key/cclm/36/11/html
Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity | Nature CommunicationsInduced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity | Nature Communications
i Violin plot of cell percentages positive for chromogranin A. j, l Representative IHC for β-catenin and E-cadherin showing ... Plasma chromogranin a in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 15, 867-871 (2009). ... IHC staining for chromogranin A showed a significantly (p , 0.0001) higher number and greater distribution of enteroendocrine ... Sidhu, R., Drew, K., McAlindon, M. E., Lobo, A. J. & Sanders, D. S. Elevated serum chromogranin A in irritable bowel syndrome ( ...
https://www.nature.com/articles/s41467-020-20351-5?error=cookies_not_supported&code=65aae6df-87ca-43c5-bf66-c7cc66530e0d
AntibodySynaptophysinSecretograninPeptideAntigenGastrinRecombinantProteinsSecretionSpecificitySecretory vesiclesBovineReagentsEndogenousPeptidesDiagnosticMarkerNeuroendocrineMeasurementProstate cancerPromoterLaboratoriesSerumAutonomicChemistryLevelsCirculationBloodExpressionProductsStudiesResponseMajor
Antibody2
  • An antibody against secretogranin I (chromogranin B) is packaged into secretory granules. (rupress.org)
  • Sheep anti Human Chromogranin antibody recognizes human chromogranin A, a secreted peptide that inhibits glucose-induced insulin release. (bio-rad-antibodies.com)
Synaptophysin2
  • Immunohistochemically, the tumor cells are positive for chromogranin, synaptophysin and neuron-specific enolase. (cap.org)
  • Chromogranin A and synaptophysin stainings were negative. (bvsalud.org)
Secretogranin5
  • Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/secretogranin family. (prospecbio.com)
  • An mAb against secretogranin I (chromogranin B), a secretory protein costored with various peptide hormones and neuropeptides in secretory granules of many endocrine cells and neurons, was expressed by microinjection of its mRNA into the secretogranin I-producing cell line PC12. (rupress.org)
  • The effects of experimental stimuli of differing duration and intensity on chromogranin B and secretogranin II mRNA levels in relevant areas of the rat brain were examined by in situ hybridization histochemistry using 35S-labelled oligonucleotides. (austin.org.au)
  • Markedly increased levels of secretogranin II (125-160% of control) and chromogranin B (140-230% of control) mRNA were observed in granule cells of the dentate gyrus 0.5-2 h after amygdaloid stimulation-induced seizures. (austin.org.au)
  • These results indicate that measurement of changes in chromogranin mRNA, particularly secretogranin II, is a useful means of assessing both rapid and long-lasting increases and decreases in neuronal activity and, in contrast to immediate early gene mRNA levels, may better reflect specific changes in neuronal secretory activity associated with transmitter/peptide release. (austin.org.au)
Peptide5
  • It is well known that peptide-producing endocrine tumours cosecrete immunoreactive chromogranin A with their characteristic hormones. (degruyter.com)
  • The potent PACAP/vasoactive intestinal peptide (VIP) type I receptor antagonist PACAP6-38 impaired both chromogranin A transcription or catecholamine secretion triggered by PACAP38, while the PACAP/VIP type II receptor antagonist (p-Chloro-D-Phe6, Leu17)-VIP had little or no ability to antagonize the PACAP38 effect. (jci.org)
  • Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. (uib.no)
  • Peptide microarrays for the characterization of antigenic regions of human chromogranin A. (genomeweb.com)
  • A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population. (cdc.gov)
Antigen1
  • Staining of paraffin embedded human pancreas with Sheep anti Human Chromogranin A ( 2095-0220 ) following pronase antigen retrieval. (bio-rad-antibodies.com)
Gastrin1
  • Chronic PPI use resulted in significant increases in CGA (including the tumor marker chromogranin A) and significant increases in gastrin compared to controls. (greenmedinfo.com)
Recombinant1
  • Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 (rCgA(1-64)) induce negative inotropic and lusitropic effects counteracting the beta-adrenergic-dependent positive inotropism with a functional noncompetitive antagonism. (unisr.it)
Proteins2
  • Chromogranin/secretogranins are a family of acidic, soluble proteins with a widespread distribution in secretory vesicles of endocrine and nervous tissues. (austin.org.au)
  • For example, chromogranin A (CgA) and chromogranin B (CgB), two of the major proteins inside secretory vesicles, aggregate because of pH- and Ca 2+ -dependent conformational changes ( Yoo and Lewis, 1996 ). (jneurosci.org)
Secretion5
  • Effects of noise on the secretion of salivary chromogranin A (CgA), which is considered to be a substitute measure of catecholamines, were investigated in a laboratory experiment. (who.int)
  • Since chromogranin A is secreted along with catecholamines, we asked whether PACAP regulates expression of the chromogranin A gene in PC12 rat chromaffin cells, so as to resynthesize the just-secreted protein, and whether such biosynthetic regulation is coupled mechanistically to catecholamine secretion. (jci.org)
  • Thus, PACAP-evoked chromogranin A transcription and catecholamine secretion are likely mediated by the PACAP/VIP type I receptor isoform. (jci.org)
  • Although the calcium channel antagonists Zn2+ (100 microM), nifedipine (10 microM), or ruthenium red (10 microM), or the cytosolic calcium chelator BAPTA-AM (50 microM) each strongly impaired PACAP-induced secretion, transcriptional activation of chromogranin A remained unaltered. (jci.org)
  • Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. (cdc.gov)
Specificity2
  • Specificity: Chromogranin Category: 49 Group: Ngl. (electroforese.com)
  • Using chromogranin A at a cut-off level of 30.3 U/ml it was possible to discriminate between patients in remission and patients suffering a relapse with a sensitivity of 91.7% and a specificity of 96.4 %, which may be of important diagnostic value. (degruyter.com)
Secretory vesicles1
  • Chromogranin A is the major soluble core component in secretory vesicles. (jci.org)
Bovine1
  • Using immunocytochemistry techniques, we demonstrated specific immunostaining with antibodies rose against fragment (547-560) and (614-626) of bovine chromogranin B (CGB) at the level of brain and the tegument of the leech Theromyzon tessulatum. (nel.edu)
Reagents1
  • Chromogranin Assay Laboratories manufactures the chromogranin a test uk reagents distributed by Genprice. (postgenomeconsortium.com)
Endogenous1
  • PACAP activated the endogenous chromogranin A gene by four- to fivefold. (jci.org)
Peptides4
  • Nonfunctioning tumors do not secrete hormone, or they may release hormonally inactive peptides such as pancreatic polypeptide (PP), chromogranin A, neurotensin, neuro-specific enolase, or ghrelin. (medscape.com)
  • Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. (unisr.it)
  • Cellular localization of a chromogranin B -like derived peptides in leeches. (nel.edu)
  • Salzet M, Verger-Bocquet M. Cellular localization of a chromogranin B -like derived peptides in leeches. (nel.edu)
Diagnostic2
  • Serum chromogranin-A in hepatocellular carcinoma: diagnostic utility and limits. (unime.it)
  • Increases in intragastric pH may result in hypergastrinemia and enterochromaffin-like cell hyperplasia and increased chromogranin A levels which may interfere with diagnostic investigations for neuroendocrine tumors. (nih.gov)
Marker5
  • Chromogranin A is a type of tumour marker. (ronnyallan.net)
  • Tumour Markers GeneralFor some years the gold standard tumour marker for Neuroendocrine Neoplasms (NENs) has been and remains today, Chromogranin A (and for certain scenarios Chromogranin B and C can provide some additional clues). (ronnyallan.net)
  • Pancreastatin, which is actually a molecule of Chromogranin A, is another marker touted but appears to be limited to USA. (ronnyallan.net)
  • Chromogranin A as a marker of osteolysis in stage D3 prostate cancer patients // Anticancer Research, 24 (2004), 5D. (irb.hr)
  • Chromogranin mRNA levels in the brain as a marker for acute and chronic changes in neuronal activity: effect of treatments including seizures, osmotic stimulation and axotomy in the rat. (austin.org.au)
Neuroendocrine2
  • A protein found inside neuroendocrine cells, which release chromogranin A and certain hormones into the blood. (ronnyallan.net)
  • Chromogranin A may be found in higher than normal amounts in patients with certain neuroendocrine tumours, small cell lung cancer, prostate cancer, and other conditions. (ronnyallan.net)
Measurement1
  • In our study that lasted over one year we could clearly show that the measurement of chromogranin A is impressively superior to 5-hydroxyindoleacetic-acid for detecting a relapse of carcinoids. (degruyter.com)
Prostate cancer1
  • Introduction: We ascertained whether plasma chromogranin A enhances the power of serology assessing prostate cancer (PC). (unicatt.it)
Promoter5
  • Proportional results (seven- to eightfold activation) were obtained with a transfected 1,200-bp mouse chromogranin A promoter/luciferase reporter construct. (jci.org)
  • A series of chromogranin A promoter 5' deletion mutant/luciferase reporter constructs narrowed down the PACAP response element to a proximal region containing the cAMP response element (CRE box), at (-71 bp)5'-TGACGTAA-3'(-64 bp). (jci.org)
  • Thus, the proximal CRE box is entirely necessary for the chromogranin A promoter response to PACAP. (jci.org)
  • Expression of a dominant-negative mutant (KCREB) of the CRE-binding factor CREB markedly diminished trans-activation of the chromogranin A promoter by PACAP. (jci.org)
  • Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. (cdc.gov)
Laboratories1
  • Chromogranin Elisa Laboratories manufactures the chromogranin 49 ngl. (electroforese.com)
Serum2
  • The Chromogranin A Test Uk reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (postgenomeconsortium.com)
  • High serum levels of chromogranin-A (CgA) have recently been reported in HCC. (unime.it)
Autonomic2
  • The increase of the autonomic nervous activity, and the decrease of chromogranin A which had been increased by taking LP posture were observed by taking HP posture. (scirp.org)
  • Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (cdc.gov)
Chemistry1
  • Enzyme-Linked Immunosorbent Assay for Chromogranin A . Clinical Chemistry , 35 , 1934-1938. (ilvo.be)
Levels1
  • In plasma samples the levels of chromogranin A (CgA) were also assayed. (unicatt.it)
Circulation1
  • Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. (ku.dk)
Blood1
  • Measuring the amount of chromogranin A in the blood may help to diagnose cancer or other conditions or find out how well treatment is working or if cancer has come back. (ronnyallan.net)
Expression1
  • Cotransfection of expression plasmids encoding the protein kinase A inhibitor, or an inactive protein kinase A (PKA) catalytic beta subunit, inhibited both forskolin and PACAP activation of chromogranin A transcription, revealing that PACAP-induced trans-activation is highly dependent on PKA. (jci.org)
Products1
Studies1
Response1
  • IMSEAR at SEARO: Salivary chromogranin A as a measure of stress response to noise. (who.int)
Major1
  • Chromogranin A, PIINP, S100A12, Hyaluronic acid - Cisbio leverages its expertise to develop unique immunoassays for major pathologies not covered by conventional biomarkers. (cisbio.eu)