A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
A type of chromogranin which was initially characterized in the ANTERIOR PITUITARY GLAND. It is found in several species including human, rat, mouse, and others. Secretogranin II is an acidic protein of 559 to 586 amino acid residues that can stimulate DOPAMINE release from neurons and release of pituitary GONADOTROPINS.
Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to GASTRIN by releasing histamine which acts as a paracrine stimulator of the release of HYDROCHLORIC ACID from the GASTRIC PARIETAL CELLS.
A subtype of enteroendocrine cells found in the gastrointestinal MUCOSA, particularly in the glands of PYLORIC ANTRUM; DUODENUM; and ILEUM. These cells secrete mainly SEROTONIN and some neuropeptides. Their secretory granules stain readily with silver (argentaffin stain).
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Tumors or cancer of the ENDOCRINE GLANDS.
Condensed areas of cellular material that may be bounded by a membrane.
A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Tumors or cancer of the ADRENAL GLANDS.
Specialized NEURONS that produce hormones, such as NEUROPEPTIDES or BIOGENIC AMINES. They generally are in the NERVOUS SYSTEM, such as HYPOTHALAMUS, but can be found in other organs or systems. These neurons contain dense neurosecretory granules and PROPROTEIN CONVERTASES allowing the rapidly release of NEUROHORMONES into the blood circulation upon stimulation.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).
A type of chromogranin which was initially characterized in a rat PHEOCHROMOCYTOMA CELL LINE. It is found in many species including human, rat, mouse, and others. It is an acidic protein with 626 to 657 amino acid residues. In some species, it inhibits secretion of PARATHYROID HORMONE or INSULIN and exerts bacteriolytic effects in others.
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins raised by any form of viral hepatitis; some of these antibodies are used to diagnose the specific kind of hepatitis.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The dilated portion of the common carotid artery at its bifurcation into external and internal carotids. It contains baroreceptors which, when stimulated, cause slowing of the heart, vasodilatation, and a fall in blood pressure.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (1/561)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Kinetics of neuroendocrine differentiation in an androgen-dependent human prostate xenograft model. (2/561)

It was previously shown in the PC-295 xenograft that the number of chromogranin A (CgA)-positive neuroendocrine (NE) cells increased after androgen withdrawal. NE cells did not proliferate and differentiated from G0-phase-arrested cells. Here we further characterized NE differentiation, androgen receptor status, and apoptosis-associated Bcl-2 expression in the PC-295 model after androgen withdrawal to assess the origin of NE cells. PC-295 tumor volumes decreased by 50% in 4 days. Intraperitoneal bromodeoxyuridine (BrdU) incorporation and MIB-1 labeling decreased to 0%, and the apoptosis was maximal at day 4. Androgen receptor expression and prostate-specific antigen (PSA) serum levels decreased rapidly within 2 days. The number of NE cells increased 6-fold at day 4 and 30-fold at day 7. Five and ten percent of the CgA-positive cells were BrdU positive after continuous BrdU labeling for 2 and 4 days, respectively. However, no MIB-1 expression was observed in CgA-positive cells. NE cells expressed the regulated secretory pathway marker secretogranin III but were negative for androgen receptor and Bcl-2. Bcl-2 expression did increase in the non-NE tumor cells. In conclusion, androgen withdrawal leads to a rapid PC-295 tumor regression and a proliferation-independent induction of NE differentiation. The strictly androgen-independent NE cells that were still present after 21 days differentiated mainly from G0-phase-arrested cells.  (+info)

Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation. (3/561)

OBJECTIVE: Islet amyloid polypeptide (IAPP), also named amylin, is the predominant protein component of amyloid deposits in human islet beta cell tumours of the pancreas (insulinomas). IAPP is co-produced with insulin by islet beta cells. We investigated IAPP expression in relation to insulin expression and to amyloid formation in eleven insulinomas. DESIGN AND METHODS: RNA and protein extracts were prepared from the same pieces of tumour tissue, and from specimens of two normal human pancreata. IAPP and insulin mRNA and peptide content were quantified using Northern blot analysis and radioimmunoassay (RIA) respectively. Molecular forms of IAPP immunoreactivity were analysed by reversed-phase high-performance liquid chromatography (HPLC). The presence of islet hormones and of amyloid was assessed by (immuno)histochemical staining of paraffin sections. Plasma levels of IAPP and insulin prior to tumour resection were determined by RIA. RESULTS: IAPP and insulin mRNA and peptide content varied widely between the tumour specimens, and there was considerable intratumour heterogeneity of peptide content. HPLC analysis indicated correct proteolytic processing of the IAPP precursor protein. Amyloid deposits were detected only in the three tumours with the highest IAPP content. In contrast to insulin, plasma levels of IAPP were not elevated in the insulinoma patients. CONCLUSIONS: The spectrum of hormone production by insulinomas cannot be inferred from only a few tissue sections due to intratumour heterogeneity. Expression of the IAPP and insulin genes is not coupled in insulinomas, which produce properly processed mature IAPP. In addition to IAPP overproduction, additional factors such as intracellular accumulation of IAPP are involved in amyloidogenesis in insulinomas.  (+info)

Library of sequence-specific radioimmunoassays for human chromogranin A. (4/561)

BACKGROUND: Human chromogranin A (CgA) is an acidic protein widely expressed in neuroendocrine tissue and tumors. The extensive tissue- and tumor-specific cleavages of CgA at basic cleavage sites produce multiple peptides. METHODS: We have developed a library of RIAs specific for different epitopes, including the NH2 and COOH termini and three sequences adjacent to dibasic sites in the remaining part of CgA. RESULTS: The antisera raised against CgA(210-222) and CgA(340-348) required a free NH2 terminus for binding. All antisera displayed high titers, high indexes of heterogeneity ( approximately 1.0), and high binding affinities (Keff0 approximately 0.1 x 10(12) to 1.0 x 10(12) L/mol), implying that the RIAs were monospecific and sensitive. The concentration of CgA in different tissues varied with the assay used. Hence, in a carcinoid tumor the concentration varied from 0.5 to 34.0 nmol/g tissue depending on the specificity of the CgA assay. The lowest concentration in all tumors was measured with the assay specific for the NH2 terminus of CgA. This is consistent with the relatively low concentrations measured in plasma from carcinoid tumor patients by the N-terminal assay, whereas the assays using antisera raised against CgA(210-222) and CgA(340-348) measured increased concentrations. CONCLUSION: Only some CgA assays appear useful for diagnosis of neuroendocrine tumors, but the entire library is valuable for studies of the expression and processing of human CgA.  (+info)

Serum gastrin and chromogranin A during medium- and long-term acid suppressive therapy: a case-control study. (5/561)

BACKGROUND: Serum chromogranin A (CgA) is regarded as a reliable marker of neuroendocrine proliferation. We previously described increased serum CgA levels during short-term profound gastric acid inhibition. AIM: To investigate serum gastrin and CgA levels in dyspeptic patients during continuous medium- (6 weeks to 1 year), or long-term (1-8 years) gastric acid suppressive therapy. PATIENTS AND METHODS: 114 consecutive dyspeptic patients referred for upper gastrointestinal endoscopy were enrolled in a cross-sectional, case-control study [62 patients on continuous antisecretory therapy, either with proton pump inhibitors (n = 47) or H2-receptor antagonists (H2RA) (n = 15) for gastro-oesophageal reflux disease with or without Barrett's oesophagus or functional dyspepsia, and 52 age- and sex-matched patients without medical acid inhibition and with normal endoscopic findings (control group)]. Omeprazole doses ranged from 20 mg to 80 mg daily and ranitidine from 150 mg to 450 mg daily. Fasting serum CgA and serum gastrin levels were measured by radioimmunoassay (reference values: serum CgA < 4.0 nmol/L; serum gastrin < 85 ng/L). RESULTS: Fasting serum CgA levels positively correlated with serum gastrin in the entire study population (r = 0. 55, P = 0.0001). Median serum CgA values were higher in patients treated with a proton pump inhibitor than H2RA [2.8 (2.0-5.9) nmol/L vs. 2 (1.9-2.3) nmol/L, P < 0.002] and controls [2.8 (2.0-5.9) nmol/L vs. 1.8 (1.5-2.2) nmol/L, P < 0.0001) and did not differ between patients treated with H2RA or controls. Serum gastrin and CgA levels in patients on proton pump inhibitor therapy positively correlated with the degree and duration of acid inhibition. Patients on long-term proton pump inhibitor therapy had significantly higher fasting serum gastrin and CgA than those on medium-term proton pump inhibitor therapy [127 (73-217) ng/L vs. 49 (29-78) ng/L, P < 0.0001 and 4.8 (2.8-8) ng/L vs. 2.1 (1.9-2.6) ng/L, P < 0.001]. No such relation was found in patients on medium- vs. long-term H2RA. Overall, patients with positive Helicobacter pylori serology had higher serum gastrin and CgA levels than those with negative H. pylori serology [51 (27-119) ng/L vs. 27 (14-79) ng/L, P = 0.01, 2.4 (1.9-3.4) nmol/L vs. 2.0 (1.7-2.5) nmol/L, P = 0.05]. CONCLUSIONS: During long-term continuous proton pump inhibitor treatment, serum gastrin and CgA levels are significantly elevated compared to H2RA treatment and nontreated dyspeptic controls. H. pylori infection seems to affect gastric ECL cell secretory function. Increased serum CgA values during long-term profound gastric acid inhibition could reflect either gastric enterochromaffin-like cell hyperfunction or proliferative changes.  (+info)

Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats. (6/561)

Dimethylbenzanthracene (DMBA) induces pancreatic adenocarcinomas in rats 9 months after carcinogen exposure, with precursor lesions (tubular complexes) developing 1 month after initiation of treatment. Because previous studies have suggested an acinar cell of origin for these tumors, we investigated the expression pattern of ductal, acinar, and islet cell markers in these cancers to gain insight into their phenotype and cell of origin. Pancreatic neoplasms were induced in rats by implantation of DMBA into the head of the pancreas. Lesions studied included 10 early tubular complexes (DMBA for 2 weeks), 8 tubular complexes (DMBA for 1 month), and 10 adenocarcinomas (DMBA for 9 months). Normal rat pancreas served as a control. For comparison, 5 human ductal adenocarcinomas were also evaluated. Immunohistochemistry with ductal (keratin, cytokeratin 19, cytokeratin 20), acinar (chymotrypsin), and islet (chromogranin A) cell markers was performed to analyze the tissues. Rat tubular complexes and adenocarcinomas revealed strong expression of keratin, cytokeratin 19, and cytokeratin 20 in the cytoplasm of all neoplastic cells, absence of chymotrypsin, and rare immunoreactivity to chromogranin A. Human adenocarcinomas showed strong expression of keratin and cytokeratin 19 in all neoplastic cells, expression of cytokeratin 20 in 5-20% of cells, and absence of chymotrypsin and chromogranin A. Pancreatic adenocarcinomas induced by DMBA in rats express markers consistent with a ductal phenotype, as observed in human tumors. Ductal marker expression in early tumor stages suggests a ductal cell of origin.  (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (7/561)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important.  (+info)

A new human chromogranin A (CgA) immunoradiometric assay involving monoclonal antibodies raised against the unprocessed central domain (145-245). (8/561)

Chromogranin A (CgA), a major protein of chromaffin granules, has been described as a potential marker for neuroendocrine tumours. Because of an extensive proteolysis which leads to a large heterogeneity of circulating fragments, its presence in blood has been assessed in most cases either by competitive immunoassays or with polyclonal antibodies. In the present study, 24 monoclonal antibodies were raised against native or recombinant human CgA. Their mapping with proteolytic peptides showed that they defined eight distinct epitopic groups which spanned two-thirds of the C-terminal part of human CgA. All monoclonal antibodies were tested by pair and compared with a reference radioimmunoassay (RIA) involving CGS06, one of the monoclonal antibodies against the 198-245 sequence. It appears that CgA C-terminal end seems to be highly affected by proteolysis and the association of C-terminal and median-part monoclonal antibodies is inadequate for total CgA assessment. Our new immunoradiometric assay involves two monoclonal antibodies, whose contiguous epitopes lie within the median 145-245 sequence. This assay allows a sensitive detection of total human CgA and correlates well with RIA because dibasic cleavage sites present in the central domain do not seem to be affected by degradation. It has been proved to be efficient in measuring CgA levels in patients with neuroendocrine tumours.  (+info)

BACKGROUND - Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. We identified a natural nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and blood pressure. METHODS AND RESULTS - Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. Case-control studies replicated effects of the gene on blood pressure in the population. Gly364Ser displayed diminished inhibition of catecholamine secretion from cultured neurons. Gly/Ser heterozygotes displayed increased baroreceptor slope during upward deflections (by ≈47%) and downward deflections (by ≈44%), increased cardiac parasympathetic index (by ≈2.4-fold), and decreased cardiac sympathetic index (by ≈26%). Renal norepinephrine excretion was diminished by ≈26% and epinephrine excretion by ≈34% in Gly/Ser ...
Heritable autonomic traits may be of particular value in investigations of the genetic underpinnings of hypertension, a complex trait with both hereditary and environmental determinants and likely even multiple genetic (or polygenic) determinants.7,8 Human twin studies indicate that baroreceptor activity is a substantially heritable trait.33 Such traits may be valuable intermediate phenotypes7,8 for hypertension, especially if they display earlier penetrance than the ultimate disease trait (DBP), can be elicited in still-normotensive individuals, and suggest testable candidate genetic loci (such as CHGA). Catestatin itself may be such a phenotype.8 Several of the autonomic phenotypes studied here (Table II and Figures 2 and 3⇑) meet these criteria.. Indeed, Gly364Ser genotypes were associated with hypertension (Figure 4a and 4b), especially in men (Figure 4b). Thus, the 364Ser allele may play a protective role against future the development of hypertension.. How might this happen? Because ...
Naturally Occurring Human Genetic Variation in the 3′-Untranslated Region of the Secretory Protein Chromogranin A Is Associated With Autonomic Blood Pressure Regulation and Hypertension in a Sex-Dependent Fashion Academic Article ...
The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. Although the precise function of the chromogranins remains elusive, knowledge of their structure, distribution, and potential intracellular and extracellular roles, especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. Thus, measurement of its circulating concentration by radioimmunoassay may be a useful probe of exocytotic sympathoadrenal activity in humans, under both physiological and pathological conditions. Here, we explore the storage, structure, and function of chromogranin A, and parameters that influence its circulating levels. We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. ...
TY - JOUR. T1 - Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas. AU - Oda, K.. AU - Inada, K.. AU - Osamura, R. Y.. PY - 1991. Y1 - 1991. N2 - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.. AB - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The structure of the gene encoding bovine chromogranin-A has been determined by characterization of two isolated genomic clones. Chromogranin-A is encoded by eight exons, which organize the coding region into several distinct structural and functional domains. Exons 1-5 represent the highly conserved signal peptide and N-terminal domain, which are separated into regions corresponding to the signal peptide, N-terminal sequence, disulfide-bonded loop, and remainder of the conserved N-terminal domain. Exon 6 represents the variable domain and encodes a region that is identical to the novel chromogranin-A-derived peptide chromostatin. Exon 7 encodes the biologically active peptide pancreastatin as well as most of the conserved C-terminal domain, with the remainder found on exon 8. The mRNA sequence obtained from the gene contains five nucleotide differences from the consensus sequence of four reported bovine chromogranin-A cDNA clones. Two of the differences in the gene result in two amino acid changes in
Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the neuroendocrine cells. It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II.
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone SPM553 ] validated in IHC-P, IF, FC (AH10405-100), Abgent
Chromogranin A / CHGA (Neuroendocrine Marker) Antibody - With BSA and Azide, Purified Mouse Monoclonal Antibody validated in WB, IHC, IF, FC, IP (AH10256-20), Abgent
Epitope Diagnostics EDI Human Chromogranin A ELISA Kit was recently used by a research group lead by Dr. Ugo De Giorgi to publish two key papers highlighting another aspect of the relationship between chromogranin A (CgA) and prostate cancer.. The two papers, published by Conteduca et al and Burgio et al, examined patients with castration-resistant prostate cancer (CRPC) who had received previous docetaxel chemotherapy treatment. Using the range established by the EDI Chromogranin A ELISA Kit, the patients were divided into three groups based on baseline CgA levels: normal CgA (,120 ug/ml), under 3 time normal (,360 ug/ml), and above 3 time normal (,360 ug/ml).. Prostate specific antigen was then monitored as the patients received antiandrogen treatment, either with abiraterone or enzalutamide, in order to track the progression free survival.. In the group treated with abiraterone, a statistically significant difference was discovered between the median progression free survival rate of those ...
Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function.. ...
ntroduction: Serum levels of Chromogranin A (CgA) were measured in consecutive patients with prostate diseases in order to evaluate the impact of age on CgA diagnostic significance. Materials and Methods: Serum levels of CgA were determinated in 217 consecutive patients immediately before prostate biopsy: CgA differences between cases (prostate cancer PC) and control (benign prostatic hyperplasia BPH) were analyzed, and CgA performance in prediction of PC was compared with age and standard diagnostic tools. CgA values were also analyzed in patients affected by PC, and compared with age and standard prognostic parameters. Results: At multivariate analysis, CgA approaches a statistically significant value as independent predictor of PC and positively correlates with age. In PC group, CgA positively correlates with age, while no correlations are found with PSA, Gleason score or stage of disease. Conclusions: Age, correlating with CgA values in overall population and in PC subgroup, emerged as a ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The mitogen-activated protein kinase (MAPK) pathway plays a pivotal role in intracellular signaling, and this cascade may impinge on cAMP response elements (CREs) of target genes. Both the MAPK pathway and chromogranin A expression may be activated by cytosolic calcium influx, and calcium-dependent signals map onto the chromogranin A promoter proximal CRE. We therefore probed the role of the MAPK pathway in chromogranin A biosynthesis after secretory stimulation of PC12 pheochromocytoma cells by the nicotinic cholinergic pathway, the physiological secretory trigger. Chemical inhibition of either MAPK or MAPK kinase blocked the response of a transfected chromogranin A promoter to nicotine or protein kinase C activation [by phorbol-12-myristate-13-acetate (PMA)], although nicotine-evoked catecholamine secretion was unaffected. Activation of the MAP kinase cascade (Ras, Raf, MAPK, or CREB kinase) by cotransfection of pathway components stimulated the chromogranin A promoter. Cotransfection of MAPK ...
Purpose: To investigate the distribution of the novel chromogranin A-derived neuropeptide serpinin in the rat eye.. Methods: The molecular form of serpinin-immunoreactivity detected by a highly specific antiserum was evaluated both by western blot analysis and reversed phase-HPLC with subsequent ELISA in the rat trigeminal ganglion (TG) and retina and the presence and distribution of the peptide was explored in the rat TG and eye by immunofluorescence.. Results: There was no band in western blots in the rat TG but two weak bands at 30 and 50 kDa in the retina. Only free serpinin but no (pGlu)-serpinin and no serpinin-RRG were detected by RP-HPLC in the rat TG and retina. Numerous small- and medium-sized cells contained serpinin-immunoreactivity in the rat TG and full colocalization with substance P was evident with a more widespread expression of serpinin. Immunoreactivity was present in nerves in the corneal, limbal, irideal, ciliary and choroidal/scleral stroma, sphincter and dilator muscle ...
Pituitary secretory protein I, CgA, Chromogranin A precursor, SP-I, CGA, chromogranin A (CgA), CHGA, chromogranin A (parathyroid secretory protein 1 ...
Product Name: Chromogranin A antibody Applications: IHC-PPredicted Target Size: Positive Controls: Form Supplied: LiquidConcentration: Purification: Ab purified
Mouse monoclonal antibody raised against full length recombinant human CHGA. Recombinant protein corresponding to full length human CHGA. (MAB14233) - Products - Abnova
NE differentiation in pancreatic carcinomas has been reported in various studies using IHC (13, 14, 15) . However, the expression of PGP9.5 and its relation to other NE markers have not been studied in pancreatic cancer to date. In this study, CGA was used as a marker for NE differentiation because it has been demonstrated to be a well-characterized marker for NE differentiation (16) . We found that tumor cells immunoreactive to CGA monoclonal antibody accounted for ,1% of the tumor cell population. On the other hand, PGP9.5 was expressed in 26 of 69 (37.7%) pancreatic cancers. These results suggested that the expression of PGP9.5 in pancreatic cancer is independent of NE differentiation.. Subsequently, we investigated a possible correlation of PGP9.5 status with clinicopathological features. Although PGP9.5 expression was not associated with tumor histology or the extent of the tumor, pancreatic cancer patients with PGP9.5 expression had significantly shorter survival times than those without ...
Mouse Monoclonal Anti-Chromogranin A Antibody (SPM553) [DyLight 650]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP. Tested Reactivity: Human. 100% Guaranteed.
Mouse Monoclonal Anti-Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P. Tested Reactivity: Human, Primate, and more. 100% Guaranteed.
Neuroblastoma (NB) is a paediatric form of cancer derived from the sympathetic nervous system. Recent genome-wide sequencing data suggest that often NB does not have a clear genetic cause, leading the authors to hypothesize that NB results from aberrations of normal development. To test this hypothesis, Anna Philpotts group used a population of anteroventral noradrenergic (AVNA) cells from Xenopus embryos. These cells share several features with mammalian sympathetic neurons, including the expression of noradrenergic-associated genetic markers such as the achaete-scute complex-like 1 (Ascl1) gene, which encodes a transcriptional driver of neurogenesis. By comparing AVNA and NB cells, the authors found that, whereas Ascl1 is only transiently expressed in AVNA cells, it is aberrantly maintained in NB, where it is phosphorylated on multiple serine-proline sites. The authors then show that differentiation of AVNA cells is enhanced by dephosphorylated Ascl1. Moreover, this process is inhibited by ...
Angiogenesis has been postulated to be critical for the pathogenesis of multiple myeloma (MM), a neoplastic disease characterized by abnormal proliferation of malignant plasma cells in the bone marrow (BM). Cleavage of the N- and C-terminal regions of circulating chromogranin A (CgA, CHGA), classically an anti-angiogenic protein, can activate latent anti- and pro-angiogenic sites, respectively. In this study, we investigated the distribution of CgA-derived polypeptides in MM patients and the subsequent implications for disease progression. We show that the ratio of pro-/anti-angiogenic forms of CgA is altered in MM patients compared with healthy subjects, and that this ratio is higher in BM plasma compared with peripheral plasma, suggesting enhanced local cleavage of the CgA C-terminal region. Enhanced cleavage correlated with increased VEGF and FGF2 BM plasma levels and BM microvascular density. Using the Vk*MYC mouse model of MM, we further demonstrate that exogenously administered CgA was ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
In development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but it is incompletely understood which dysregulated mechanisms cause SC overpopulation. Because neuroendocrine cell (NEC) and SC populations both reside in the SC niche at the normal crypt bottom, we hypothesized that i) NECs play a role in maintaining the SC population, and ii) changes in the NEC population contributes to SC overpopulation and altered epithelial: stromal interactions during tumorigenesis. Immunofluorescence mapping and flow cytometry were used to analyze SC niche structure and cell-cell interactions in normal and neoplastic colonic tissues from Caucasian and African-American patients. In normal colonic crypts, most cells (77%) staining positively for the colonic SC marker ALDH1, also co-stained for the NE cell marker chromogranin-A (CGA). In the progression from normal to normal-appearing FAP to adenomatous to malignant colonic tissue, the proportion of ...
Farging immunhistokjemiske analyser (ER, Synaptophysin, Vimentin, E-cadherin (CDH1), CEA mono, Programmed death ligand 1 (PDL1), ALK D5F3, CD5, CD23, CD30, CD117, PAX8, PSA, S100, CD31, CD34, CDX2, CK5/6, CK20, CK-PAN (MNF116), CyclinD1, Desmin, Ki67, p40, SOX10, TTF1, Chromogranin A (CGA), Melan-A, HER-2 IHC, CK14, CD3, CD20, CD10, CK7, p16, p53, IgL - Kappa/ IgL - Lamda ...
Immunohistochemistry, is a special staining process performed on tissue removed during biopsy. Immunohistochemistry for lung cancer represents an important complementary tool for the routine diagnosis of lung cancer and for the identification of the different histological types and prognostic factors. We offer panel of IHC markers: TTF 1, p63, Ck 7, Ck 5/6, Napsin, Chromogranin and Ck 20.. ...
This article discusses the importance of testing for Chromogranin A levels in a variety of tumors, especially in the adrenal gland. Learn how this test works and what the results mean.
Not the biggest profit for over 2k BCs but... This guy is in the same system as me so it took very little deut to fly, not to mention only under 15 minutes ther
Ive been busy lately but I havent been inactive so I post the CRs that are days old. To be honest Im not particularly proud of this one because Ive sent th
BioTek Product Accessory, Part Number: 1210514, for use with Lionheart FX自動化活細胞影像系統 and Cytation 5 自動化影像系統暨多功能光學檢測儀
Background: Hypertension is a complex trait, with deranged autonomic control of circulation. Chromogranin B (CHGB) is the most abundant core protein in human catecholamine secretory vesicles, playing an important role in their biogenesis. Does common interindividual variation at the CHGB locus contribute to phenotypic variation in CHGB and catecholamine secretion, autonomic stability of circulation, or blood pressure (BP) in the population? Methods and Results: To probe interindividual variability in CHGB, we systematically studied polymorphism across the locus by resequencing CHGB (≈6 kbp footprint spanning the promoter, 5 exons, exon/intron borders, untranslated regions) in 160 subjects (2n=320 chromosomes) of diverse biogeographic ancestries. We identified 53 single-nucleotide polymorphisms, of which 22 were common. We then studied 1182 subjects drawn from the most extreme BP values in the population (highest and lowest 5th percentiles), typing 4 common polymorphisms spanning the ≈14 kbp ...
TY - JOUR. T1 - Chromogranin A. T2 - Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland. AU - Helle, K. B.. AU - Marley, P. D.. AU - Angeletti, R. H.. AU - Aunis, D.. AU - Galindo, E.. AU - Small, D. H.. AU - Livett, B. G.. PY - 1993. Y1 - 1993. N2 - Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-secreted with adrenaline and noradrenaline in the adrenal medulla. A number of biologically active fragments of CGA (CGAFs) have been characterized including a group of small N-terminal fragments collectively named vasostatins due to their vascular inhibitory activity. In the present study, the release of CGAFs, including CGA N-terminal fragments, from the isolated, retrogradely perfused bovine adrenal gland, has been studied under basal conditions and during nerve stimulation and perfusion with acetylcholine. The CGAFs were characterized by SDS-PAGE followed by immunoblotting with antisera to specific sequences within ...
PRIMARY OBJECTIVES:. l. To assess the progression-free survival rate of patients with locally advanced or metastatic pancreatic neuroendocrine tumors treated with everolimus alone or everolimus plus bevacizumab.. SECONDARY OBJECTIVES:. I. To compare progression-free survival (PFS) among treatment arms shown to be efficacious.. II. To estimate the overall tumor response rate in patients with metastatic pancreatic neuroendocrine tumors treated with one of two novel regimens.. III. To estimate the overall biochemical response rate (as measured by plasma chromogranin A levels) in patients with metastatic pancreatic neuroendocrine tumors treated with these regimens.. IV. To assess the toxicity of each regimen in patients with metastatic pancreatic neuroendocrine tumors.. V. To assess the overall survival of patients with pancreatic neuroendocrine tumors treated with these regimens.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive everolimus orally (PO) once daily ...
Introduction: Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). CgA assays may have different sensitivities, which is of importance for the clinical diagnosis and handling of NET patients ...
CHGB - CHGB (Myc-DDK-tagged)-Human chromogranin B (secretogranin 1) (CHGB) available for purchase from OriGene - Your Gene Company.
|i|Background and Aim|/i|. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with irritable bowel syndrome (IBS). |i|Methods|/i|. The present study was undertaken to evaluate the density of duodenal CgA as a biomarker for the diagnosis of IBS. Two hundred and three patients with IBS were recruited (180 females and 23 males; mean age, 36 years; range, 18–66 years). The control group comprised 86 healthy subjects without gastrointestinal complaints (77 females and 9 males; mean age, 38 years; range, 18–67 years). Biopsy samples were taken from the duodenum during gastroscopy. Sections from these biopsy samples were immunostained for CgA using the avidin-biotin complex (ABC) method. CgA cell density was quantified by computerized image analysis. |i|Results|/i|. The CgA cell density was lower in IBS-total and in all of the IBS subgroups than in the controls. The sensitivity and specificity for a cutoff of <200 
Fingerprint Dive into the research topics of Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A. Together they form a unique fingerprint. ...
Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance
Results: SAHA treatment of BON and H727 carcinoid tumor cells resulted in increased expression of acetylated histone 4, indicating HDAC inhibition. Furthermore, SAHA treatment led to a dose-dependent induction of the neuroendocrine signaling protein Notch1 in both its full-length and active, cleaved forms. Achaete-scute complex-like 1 (ASCL1), a downstream target of Notch1 signaling known to regulate the neuroendocrine phenotype, was suppressed by SAHA. Carcinoid tumor cell proliferation was inhibited by the drug in a dose-dependent manner. The mechanism of growth inhibition was G1 cell cycle arrest, as evidenced by increased protein levels of p21 and p27, and suppression of cyclin D1, in SAHA-treated cells ...
Principal Investigator: Kurt Beil, ND, LAc, MPH. This study examines the effects of different environmental settings on objective and subjective measures of physical and mental well-being. Participants (n=30) are taken for one hour per week to one of three different environmental settings: 1) Forested nature park, 2) Urban built plaza, and 3) Indoor windowless auditorium. One setting is visited per week, for three successive weeks; the setting visitation order is randomized individually. Participants are asked to sit quietly in each setting and observe their surroundings while data is collected.. Primary outcome measures (salivary Cortisol, Alpha-amylase & Immunoglobulin AA) are collected pre- and post-environmental setting exposure. Secondary outcome measures include pre- and post-exposure affective (POMS, SVS) and cognitive (DSB) questionnaires. Exploratory measures (i.e. salivary Chromogranin A) are also collected pre- and post-exposure. Potential co-factors including environmental identity ...
Section 4.4. New Paragraph inserted after Paragraph 4. Interference with laboratory tests. Increased CgA level may interfere with investigations for neuroendocrine tumours. To avoid this interference the omeprazole treatment should be temporarily stopped five days before CgA measurements. Section 5.1 Other effects related to acid inhibition Paragraph 3 amended to:. Chromogranin A (CgA) also increases due to decreased gastric acidity. This CgA modifying effect can not be demonstrated five days after stopping treatment with PPIs. Section 10. Date of revision changed to 20th January 2012. ...
Complete information for CHGB gene (Protein Coding), Chromogranin B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CHGA gene (Protein Coding), Chromogranin A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
I think you have a few issues 1) Gut wise you need make sure you have IBS - if not already I would recommend a endoscopy of both ends - especially colon - you may have an adenoma, or celliacs or ulcers making you feel unwell. So I would get this sorted to see if there is any pathology causing your IBS symptoms - if there is a reason for this you could be treated and you could be 100% better. 2) you have a lot of pain - I would see a neurologist to work you up. I would get some MRI imaging done of your brain, neck and spine. I would also get a bone scan done to see if this is clear. 3) The rib pain - I would get a simple chest x-ray to show this is clear. 4) Some blood tests - do a full blood count, iron studies, liver function, electrolytes, renal function, PTH, Vit D, Corrected Calcium, B12, folate, ACE, CEA, Chromogranin A, HCG, Cortisol, Testosterone, LH, FSH, also your cholesterol and lipid profile, CRP, ESR. It is not good to be negative - make sure your health comes first - follow-up with ...
3M™ CeQUINBORD CGA Inorganic Insulating Board provides excellent thermal stability and long term voltage endurance for dry-type transformers in applications such as core tubes, spacers, end fills and ground insulation. Available from 1/32%22 to 1/8%22 (.79 to 3.2mm) thickness, CeQUINBORD CGA board is a cost-effective solution for major insulation applications rated through Class 220(R).
TY - JOUR. T1 - Chromogranin a in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms. T2 - A large series from a single institution. AU - Massironi, Sara. AU - Rossi, Roberta Elisa. AU - Casazza, Giovanni. AU - Conte, Dario. AU - Ciafardini, Clorinda. AU - Galeazzi, Marianna. AU - Peracchi, Maddalena. PY - 2014/2/6. Y1 - 2014/2/6. N2 - Background/Aims: Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. Patients and Methods: A total of 181 GEP-NEN patients (87 males, 94 females) with pancreatic (n = 81) and gastrointestinal neoplasms (n = 100) were included; 99 patients had grade (G)1 NENs (Ki-67 ≤2%), 57 G2 NENs (Ki-67 3-20%) and 25 G3 NENs (Ki-67 ,20%); 81 patients had tumor-node-metastasis (TNM) stage I, 14 stage II, 17 stage ...
Neuroendocrine tumours (NETs) are rare tumours that originate from neuroendocrine cells and their incidence has increased for the last 20 decades; partly because of advances in diagnostic tools, which have improved detection rates. Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. As a result, we hypothesised that plasma CgB concentration is a more accurate and reliable prognostic indicator in NET patients. Data from 121 NET patients were collected retrospectively and submitted to statistical analyses. In univariate survival analysis, circulating CgB levels were associated with a significantly poorer survival time than CgA. In addition, multivariate analysis was performed by considering other prognostic ...
Common Functional Genetic Variants in Catecholamine Storage Vesicle Protein Promoter Motifs Interact to Trigger Systemic Hypertension Academic Article ...
High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index | 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogranin A (CgA) and somatostatin-receptor 2a (SSTR-2a) may be a feature of well-differentiated tumours. The aim of this study was to elucidate the expression and prognostic value of these three markers in 163 GEP-NEN patients with a Ki67-index | 20%. Clinical data, histopathology and overall survival were analysed according to Kaplan-Meiers method and Cox regression. The expression of SSTR-2a, CgA and synaptophysin was analysed in tumour specimens by immunohistochemistry, and semi-quantitatively scored as negative (| 5%), heterogeneously positive (5-30%) or strongly positive (| 30%). P53 was defined as normal when scored as heterogeneously positive (1-30%), and abnormal when negative (0%) or strongly
Granins are major constituents of dense-core secretory granules in neuroendocrine cells, but their function is still a matter of debate. Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. Here we report the generation and characterization of mice lacking chromogranin B (CgB-ko), which were viable and fertile. Unlike neuroendocrine tissues, pancreatic islets of these animals lacked compensatory changes in other granins and were therefore analyzed in detail. Stimulated secretion of insulin, glucagon and somatostatin was reduced in CgB-ko islets, in parallel with somewhat impaired glucose clearance and reduced insulin release, but normal insulin sensitivity in vivo. CgB-ko islets lacked specifically the rapid initial phase of stimulated secretion, had elevated basal insulin release, and stored and released twice as much proinsulin as wildtype (wt) islets. Stimulated release of
Biosynthetic transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is mediated by secretory vesicles. We analyzed secretory vesicle transport in real time using a GFP-tagged secretory protein, hCgB-GFP, consisting of human chromogranin B (hCgB) and green fluorescent protein (GFP). The fusion protein was expressed transiently in Vero cells or in a stable clone after induction with butyrate. After arrest of the biosynthetic protein transport at 20 degrees C, fluorescent hCgB-GFP colocalized with TGN38, a marker of the TGN. Subsequent release of the secretion block at 37 degrees C led to the formation of green fluorescent vesicles. Confocal analysis revealed that these vesicles were devoid of TGN38 and of Texas Red-coupled transferrin and cathepsin D, markers of the endosomal/lysosomal pathway. As determined by fluorometry and metabolic labelling hCgB-GFP was secreted from the TGN to the PM with a t(1/2) of 20-30 minutes. Video-microscope analysis of green fluorescent vesicles ...
Compare Secretogranin III ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
Melkam A. Kebede, Angie T. Oler, Trillian Gregg, Allison J. Balloon, Adam Johnson, Kelly Mitok, Mary Rabaglia, Kathryn Schueler, Donald Stapleton, Candice Thorstenson, Lindsay Wrighton, Brendan J. Floyd, Oliver Richards, Summer Raines, Kevin Eliceiri, Nabil G. Seidah, Christopher Rhodes, Mark P. Keller, Joshua L. Coon, Anjon Audhya, Alan D. Attie. ...
Gastroenterology Research and Practice is a peer-reviewed, Open Access journal that provides a forum for researchers and clinicians working in the areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis, and therapy of gastrointestinal diseases.
BACKGROUND/AIMS: In previous studies we found strong evidence for the existence and activation in human liver of putative progenitor cells resembling oval cells in rat liver. In view of the known role of rat oval cells in regeneration and hepatocarcinogenesis, we investigated a possible correlation between human putative progenitor cells and different types of dysplastic foci. METHODS: We determined the immunohistochemical phenotype of dysplastic foci found in 20 cirrhotic liver explants of various etiology, using specific antibodies against hepatocyte-type cytokeratin (CK) 8 and CK18, bile duct-type CK7 and CK19, chromogranin-A (chrom-A) and rat oval cell marker OV-6. RESULTS: All 12 foci of large cell dysplasia had a phenotype similar to that of surrounding parenchyma. Oncocytic foci showed a strong cytoplasmic staining for CK7. Three out of six of these foci contained progenitor cells, which are small cells immunoreactive for CK18, CK7, CK19, OV-6, chrom-A and stained more intensely for CK8 ...
Introduction: There is now general awareness that treatment with proton pump inhibitors (ppi) may cause moderate rises in circulating concentrations of gastrin and/or chromogranin A (CgA), thus decreasing the specificity of these markers in the diagnosis of neuroendocrine tumors (NETs). Due to their high efficacy, proton pump inhibitors (ppi) are one of the most frequently prescribed classes of drugs worldwide. Several studies in various countries report that 30% or more of in-patients have been prescribed ppi. Patients who are suspected of having a neuroendocrine tumor (NET) often have gastrointestinal (GI) symptoms for which ppi are prescribed and therefore they may be already taking ppi when their first blood sample is assayed for NET markers. We previously encountered a case of extreme rise in CgA which flagged the possibility of a NET, but was later shown to be due to ppi therapy alone. We present CgA and gastrin data in relation to ppi therapy and withdrawal for this patient. In order to ...
Product Description specificalThe micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Human CGalpha. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human CGalpha and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human CGalpha, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit(RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of Human CGalpha. You can calculate the concentration of Human CGalpha in the samples by comparing the RLU value of the samples to the standard curve. ...
Health,...Vitamin A-derived retinoic acid helps guide development scientists sa...MONDAY Nov. 19 (HealthDay News) -- U.S. researchers say theyve uncov...Retinoic acid plays a vital role in embryo development acting as a si...When humans consume vitamin A -- found in many foods including carrot...,Research,Reveals,Nutrients,Impact,on,the,Embryo,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
NS-398 inhibits COX-2 enzyme activity in a concentration dependent manner, the IC50 being 3.8 μM, whereas NS-398 at 100μM has no effect on COX-1 activity[1]. At 10 μM, NS-398 treatment results in increased production of COX-2 and the pro-inflammatory cytokine. NS-398 (10 μM) induces apoptosis in LNCaP cells, but not in the more aggressive, androgen-unresponsive C4-2b cells. The C4-2b cells are observed to continue to proliferate when treated with NS-398 and continues to retain malignant phenotype characteristics. NS-398 treatment results in C4-2b cell differentiation into an unusual neuroendocrinelike cell. These neuroendocrine-like cells produces both epithelial (cytokeratin 18 and prostate specific antigen) and neuronal (neuron-specific enolase and chromogranin A) proteins. Furthermore, this C4-2b cellular response to NS-398 is mediated by NF-kB transcription factor activation. NS-398 induces NF-kB and down-regulates Ikβ-α protein expression in LNCaP C4-2b cells[2]. ...
Our results showed that gene expressions faithfully recapitulate immunohistochemical subtype markers, as chromogranin A in carcinoids, cytokeratin 5, p63 in SQ, and TTF1 in non-squamous types. Moreover, biological information with putative clinical relevance was revealed as potentially novel diagnostic genes for each subtype with specificity 93-100% (AUC = 0.93-1.00). Cancer subtypes were characterized by (a) differential expression of treatment target genes as TYMS, HER2, and HER3 and (b) overrepresentation of treatment-related pathways like cell cycle, DNA repair, and ERBB pathways. The vascular smooth muscle contraction, leukocyte trans-endothelial migration, and actin cytoskeleton pathways were overexpressed in normal tissue.. ...
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Expression of CHGA () in adrenal gland tissue. Antibody staining with HPA017369, CAB000023, CAB040544, CAB055506 and CAB058688 in immunohistochemistry.
TY - JOUR. T1 - PANCREASTATIN BINDING-SITES AND ACTION IN INTACT AND PERMEABILIZED RINM5F CELLS. AU - Szecowka, J. AU - Shibier, O. AU - Flatt, Peter. AU - Berggren, PO. AU - Ostenson, CG. AU - Efendic, S. PY - 1992/8. Y1 - 1992/8. M3 - Article. VL - 35. SP - A76. JO - Diabetologia. JF - Diabetologia. SN - 0012-186X. IS - Suppl.. ER - ...
Looking for the definition of CGA? Find out what is the full meaning of CGA on Abbreviations.com! Carrier Group Alarm is one option -- get in to view more @ The Webs largest and most authoritative acronyms and abbreviations resource.
We have generally been helping promote bands that Død is in contact with. The actual releases under the label are Dethcentriks discography, which on the single release of Rip My Heart Out includes a remix by the industrial group Cold Metal Future, we co-released one split between Dethcentrik and Bassookah, although their label actually was the official imprint, and Død Bevertes solo album. That said, we want it to be known we are willing to work with bands to the extent they need, and many bands that we help want to remain independent altogether, so we simply promote them, and in a few cases we have worked with the label Seven Times More Scary Productions to get bands Død is in contact with into compilations. Many of the bands we work with do not understand how label contracts work, and in many cases for rights reasons and to keep our bases covered we have to do as little as possible until we know we can do more. We like to help bands in a way that they will appreciate it, rather than feel ...
Monoklonale und polyklonale CHGB Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für CHGB Antikörper. Hier bestellen.
Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. ... Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic ...
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... "Entrez Gene: SCG3 secretogranin III". Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) ... "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of ...
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of ...
2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human ... Chromogranin Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... 2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1-3): 13-21. doi:10.1016/j.regpep.2008.07. ...
If metanephrine values are equivocal, chromogranin A can be used as an adjunct marker to predict the presence of a tumor. ... Other additional biomarkers can be helpful to aid in the diagnosis of pheochromocytoma as well, most notable is Chromogranin A ... d'Herbomez M, Do Cao C, Vezzosi D, Borzon-Chasot F, Baudin E (September 2010). "Chromogranin A assay in clinical practice". ... However, a 2006 report from Italy found that over 90% of studied pheochromocytoma patients demonstrated elevated chromogranin A ...
Chromogranin A and platelets serotonin are increased.[clarification needed] Transthoracic echocardiogram shows valve thickening ... Nobels FR, Kwekkeboom DJ, Bouillon R, Lamberts SW (1998). "Chromogranin A: its clinical value as marker of neuroendocrine ... Markers of the condition such as chromogranin-A are imperfect indicators of disease progression. Prognosis varies from ...
... they are negative for chromogranin and pancreatic enzymes. The diagnosis of solid pseudopapillary tumour of the pancreas is ...
The cells are negative with chromogranin, synaptophysin and CK20. The major diagnosis from which to separate ceruminous adenoma ...
Soell M, Feki A, Hannig M, Sano H, Pinget M, Selimovic D (February 2010). "Chromogranin A detection in saliva of type 2 ... chromogranin A) was over-expressed in 100% of diabetic patients when compared to controls. In 2010 Qvarnstrom, et al., ...
Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is cleaved into the ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...
Koeslag, Johan H.; Saunders, Peter T.; Wessels, Jabus A. (1999). "The chromogranins and counter-regulatory hormones: do they ...
Aside from the hormones of secretory tumors, the most important markers are: chromogranin A (CgA), present in 99% of metastatic ... Neuroendocrine secretory protein-55, a member of the chromogranin family, is seen in pancreatic endocrine tumors but not ... Widely used neuroendocrine tissue markers are various chromogranins, synaptophysin and PGP9.5. Neuron-specific enolase (NSE) is ... chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated. Functional tumors are ...
... or chromogranin. Lung cancer staging is an assessment of the degree of spread of the cancer from its original source. It is one ...
"The chromogranins and counter-regulatory hormones: do they make homeostatic sense?". Journal of Physiology. 517 (3): 643-649. ...
... , also known as Chromogranin B, is a protein that in humans is encoded by the CHGB gene. It is a member of the ...
Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal ... conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin ...
... chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56. The cells have a round, epithelial morphology, and are adherent ...
"Increased chromogranin A and neuron-specific enolase in rats with chronic nonbacterial prostatitis induced by 17-beta estradiol ...
... chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. In total, 85% of ... immunohistochemistry is generally positive for chromogranin and synaptophysin. Genetic testing thereof typically shows altered ...
Diagnostically, it is often used in combination with chromogranin A. List of human genes Synaptophysin has been shown to ...
"Selective localization of the parathyroid secretory protein-I/adrenal medulla chromogranin A protein family in a wide variety ...
An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...
With immunohistochemistry, the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron ...
Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely ... chromogranin A (CgA), synaptophysin and neuron-specific enolase (NSE) (three proteins that are used as markers for ... chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or ...
... chromogranin A, gastrin-releasing peptide (GRP), and cholecystokinin. These cells can be the source of several types of lung ...
1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells ...
... is a peptide hormone secreted from the chromogranin A-positive enteroendocrine cells called the K-cells in the mucous ...
Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's ...
Chromogranin → - NSE (neuron-specific enolase) → ++ NFP (neurofilament protein) → - CD56/N-CAM (neural cell adhesion molecule ...
... a glycoprotein hormone Chromogranin A, a member of the granin family of neuroendocrine secretory proteins A codon for the amino ...
In humans, chromogranin A protein is encoded by the CHGA gene. Examples of cells producing chromogranin A (ChgA) are chromaffin ... Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. See chromogranin A ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory ...
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
The level of chromogranin A in the blood is normally low. A person with no signs or symptoms and a normal level of CgA is ... The chromogranin A (CgA) test is used as a tumor marker. It may be ordered in combination with a 5-HIAA test to help diagnose ... Should everyone have a chromogranin A test?. No. This test is usually ordered to help diagnose and monitor a carcinoid or other ... Chromogranin A can also be increased in people who take proton pump inhibitors (PPIs), which are drugs that reduce the amount ...
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.. *Secretogranin 2 (chromogranin C): A sulfated ... Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly ... Granins (chromogranins or secretogranins) [PMID: 2053134] are a family of acidic proteins present in the secretory granules of ...
It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. ... Chromogranin A is a secretory protein, composed of 439 amino acids, found in the large dense-core vesicles of the ... It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. Chromogranin A contains ... encoded search term (Chromogranin A) and Chromogranin A What to Read Next on Medscape ...
... ; find Sigma-Aldrich-238M9 MSDS, related peer-reviewed papers, technical ... Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin- ... Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles ... The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA ...
Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer, D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... Chromogranin A. Storage and release in hypertension.. M A Takiyyuddin, J H Cervenka, R J Hsiao, J A Barbosa, R J Parmer and D T ... especially that of chromogranin A, has greatly expanded during recent years. Chromogranin A is coreleased with catecholamines ...
Rabbit polyclonal Chromogranin A antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Dog, Human, Pig, Monkey. ... Anti-Chromogranin A antibody (ab45179) at 1/1000 dilution (purified) + PC-12 cell lysate at 20 µg. Secondary. Goat Anti-Rabbit ... Anti-Chromogranin A antibody (ab45179) at 1/5000 dilution (purified) + SH-SY5Y cell lysate at 10 µg. Secondary. Goat Anti- ... Anti-Chromogranin A antibody (ab45179) at 1/10000 dilution (unpurified) + PC-12 cell lysate at 10 µg. Secondary. HRP-conjugated ...
Compare Anti-Chromogranin A Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, ... Anti-Chromogranin A Antibody Products. Chromogranin A, also known as parathyroid secretory protein 1, or CGA is a secretory ... Chromogranin A is a well characterized cancer biomarker and is elevated in adrenal and gastrointestinal neuroendocrine tumors. ...
References for Abcams Anti-Chromogranin C antibody (ab96589). Please let us know if you have used this product in your ...
Evaluation of psychosomatic stress in children by measuring salivary chromogranin A.. Lee T1, Shimizu T, Iijima M, Obinata K, ... To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction ...
Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. J Biol Chem. 2003; 278 ... Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell. 2001; 106: 499-509. ... Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005; 115: 1942-1952 ... A panel of 11 region-specific radioimmunoassays for measurements of human chromogranin A. Regul Pept. 2004; 117: 219-227. ...
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... chromogranin explanation free. What is chromogranin? Meaning of chromogranin medical term. What does chromogranin mean? ... Looking for online definition of chromogranin in the Medical Dictionary? ... Chromogranin , definition of chromogranin by Medical dictionary https://medical-dictionary.thefreedictionary.com/chromogranin ... chromogranin. Also found in: Acronyms, Wikipedia. chro·mo·gran·in. (krōmō-granin), A soluble and secretory hormone proteins ...
Jetzt Chromogranins versandkostenfrei online kaufen & per Rechnung bezahlen bei Weltbild.de, Ihrem Bücher-Spezialisten! ... Rezension zu „Chromogranins ". I recommend Chromogranins for students and basic scientists interested not only in chromogranins ... Proteolytic processing of chromogranins; A. Laslop, et al. 13. Endothelial handling of chromogranin A; M. Mandalà, et al. 14. ... Inhaltsverzeichnis zu „Chromogranins ". Part 1: Introduction. 1. The chromogranins: Historical perspectives; K.B. Helle. 2. ...
chromogranin-A , chromogranin A , cgA , SP-I , betagranin (N-terminal fragment of chromogranin A) , parathyroid secretory ... Chromogranin A (CHGA) Antigen-Profil Beschreibung des Gens The protein encoded by this gene is a member of the chromogranin/ ... anti-Chromogranin A (CHGA) Antikörper. Bezeichnung:. anti-Chromogranin A Antikörper (CHGA). Auf www.antikoerper-online.de ... Weitere Antikörper gegen Chromogranin A Interaktionspartner. Zebrafish Chromogranin A (CHGA) Interaktionspartner * Study ...
Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Chromogranin A is a T cell antigen in human type 1 diabetes J Autoimmun. 2014 May;50:38-41. doi: 10.1016/j.jaut.2013.10.003. ... Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand ... Keywords: Autoantigen; Autoreactive CD4 T cells; Chromogranin A; Human; Post-translational modification; Type 1 diabetes. ...
anti-Chromogranin A, PerCP, Clone: SPM553, Novus Biologicals 100 Tests; PerCP Life Sciences:Antibodies:Primary Antibodies:Flow ... betagranin (N-terminal fragment of chromogranin A), CGA, chromogranin A (parathyroid secretory protein 1), chromogranin-A, ... Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. It is validated for Western Blot, Flow ... Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and ...
Secretogranin II (chromogranin C), bImported. ,p>Information which has been imported from another database using automatic ... tr,A0JMK6,A0JMK6_DANRE Secretogranin II (chromogranin C), b OS=Danio rerio OX=7955 GN=scg2b PE=2 SV=1 ...
i,Background and Aim,/i,. Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is ... Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome,. Gastroenterology Research ... Chromogranin A (CgA) is a common marker for endocrine cells. The density of duodenal CgA cells is reduced in patients with ... L. J. Deftos, "Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker," Endocrine ...
Shop a large selection of products and learn more about Thermo Scientific Lab Vision Chromogranin A Ab-1, Mouse Monoclonal ... Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Host Species: Mouse. ... Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout ... reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse ...
Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/ ... CHGA, CGA, Chromogranin-A, Vasostatin I, SP-I, Pituitary secretory protein I. ...
Chromogranin A is a 439 amino acid protein which is encoded on chromosome 14 and is present in neuroendocrine cells throughout ... Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. ... CHGA, CGA, Chromogranin-A, Vasostatin I, SP-I, Pituitary secretory protein I. ...
Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously ... Bioclinica Lab employs a manual sandwich radioimmunoassay designed for the measurement of whole and fragmented Chromogranin A ...
Mouse Monoclonal Anti-Chromogranin A Antibody (SPM553) [DyLight 650]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC/IF ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (SPM553) [DyLight 650] ... Reviews for Chromogranin A Antibody (NBP2-34795C) (0) There are no reviews for Chromogranin A Antibody (NBP2-34795C). By ... Alternate Names for Chromogranin A Antibody (SPM553) [DyLight 650]. *betagranin (N-terminal fragment of chromogranin A) ...
Study Using Chromogranin A as Surveillance Biomarker in Patients with cARcinoids. * Print details ... The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II ...
Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific ... Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. It has a general ...
Mouse Monoclonal Anti-Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. Neuroendocrine Marker. Validated: WB, ELISA, Flow, ICC ... Home » Chromogranin A » Chromogranin A Antibodies » Chromogranin A Antibody (PHE5) [Alexa Fluor® 700] ... Alternate Names for Chromogranin A Antibody (PHE5) [Alexa Fluor® 700]. *betagranin (N-terminal fragment of chromogranin A) ... PTMs for Chromogranin A Antibody (NBP2-34709AF700). Learn more about PTMs related to Chromogranin A Antibody (NBP2-34709AF700). ...
... chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to amyotrophic ... Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis Proc Natl Acad Sci ... Recently, chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to ...
  • Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins. (wikipedia.org)
  • In humans, chromogranin A protein is encoded by the CHGA gene. (wikipedia.org)
  • Examples of cells producing chromogranin A (ChgA) are chromaffin cells of the adrenal medulla, paraganglia, enterochromaffin-like cells and beta cells of the pancreas. (wikipedia.org)
  • The catecholamine storage vesicle protein chromogranin A (CHGA) 1 plays a necessary role in formation of catecholamine secretory granules. (ahajournals.org)
  • Auf www.antikoerper-online.de finden Sie aktuell 1025 Chromogranin A (CHGA) Antikörper von 40 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Chromogranin A (ChgA) is a beta cell secretory granule protein and a peptide of ChgA, WE14, was recently identified as a ligand for diabetogenic CD4 T cell clones derived from the NOD mouse. (nih.gov)
  • In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. (diva-portal.org)
  • Chromogranin-A Isoform 1 Preproprotein or CHGA is part of the neuroendocrine secretory proteins of the chromogranin/secretogranin family. (prospecbio.com)
  • Anti-CHGA / Chromogranin A antibody IHC of human adrenal. (antibodies-online.com)
  • We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545 US and 1252 Australian subjects. (diva-portal.org)
  • Cleavage of the N- and C-terminal regions of circulating chromogranin A (CgA, CHGA), classically an anti-angiogenic protein, can activate latent anti- and pro-angiogenic sites, respectively. (aacrjournals.org)
  • Adrenal medullary mRNA and protein levels of other dense-core secretory granule proteins including chromogranin B, and secretogranins II to VI were up-regulated 2- to 3-fold in the Chga null mutant mice. (ovid.com)
  • General Description of Chromogranin A / CHGA. (enquirebio.com)
  • Variations in Chromogranin A / CHGA antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
  • Low, but measureable presence of Chromogranin A / CHGA could be seen inneuronal cells in the caudate nucleus, cerebral cortex and hippocampus, respiratory epithelial cells in the bronchus and neuronal cells in the caudate nucleus and cerebral cortex and hippocampus. (enquirebio.com)
  • We were unable to detect Chromogranin A / CHGA in other tissues. (enquirebio.com)
  • Tissues from cancer patients, for instance, have their own distinct pattern of Chromogranin A / CHGA expression as measured by anti-Chromogranin A / CHGA antibody immunohistochemical staining. (enquirebio.com)
  • CHGA (Chromogranin A) is a Protein Coding gene. (genecards.org)
  • It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. (fujita-hu.ac.jp)
  • Chromogranin A Monoclonal antibody specifically detects Chromogranin A in Human samples. (fishersci.com)
  • Obtain accurate, reproducible results in immunohistochemistry and western blotting experiments with Thermo Scientific Chromogranin A Ab-1, Mouse Monoclonal Antibody. (fishersci.com)
  • There are currently no images for Chromogranin A Antibody (NBP2-34795C). (novusbio.com)
  • This antibody recognizes Chromogranin A, which is present in neuroendocrine cells. (biotium.com)
  • PC-12 cells were subjected to SDS PAGE followed by western blot with 10529-1-AP (Chromogranin A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10529-1-AP (Chromogranin A antibody) at dilution of 1:1600 (under 40x lens). (ptglab.com)
  • Immunofluorescent analysis of (4% PFA) fixed mouse pancreas tissue using 10529-1-AP (Chromogranin A antibody), at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). (ptglab.com)
  • Immunofluorescent analysis of (-20°C Ethanol) fixed PC-12 cells using 60135-1-Ig (Chromogranin A antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). (ptglab.com)
  • The objective of this study was to develop and validate a time-resolved immunofluorometric assay (TR-IFMA) for porcine salivary chromogranin A (CgA) measurements, using a species-specific antibody, and evaluate its behaviour in an acute stress model. (semanticscholar.org)
  • Enzyme-linked immunosorbent assay for detection of canine chromogranin A by use of immunological cross-reactivity of rabbit anti-bovine chromogranin A antibody. (semanticscholar.org)
  • This antibody is designed for the specific localization of human Chromogranin A using IHC techniques in formalin-fixed, paraffin-embedded tissue sections. (gennovascientific.com)
  • This antibody is useful when demonstrating co-expression of chromogranin and NSE, which is typical of neuroendocrine neoplasms. (histopat.hu)
  • Western Blot analysis of PC-3 cells using Chromogranin A Polyclonal Antibody at dilution of 1:500. (elabscience.com)
  • Immunohistochemistry of paraffin-embedded Human duodenum using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
  • Immunohistochemistry of paraffin-embedded Mouse small intestine using Chromogranin A Polyclonal Antibody at dilution of 1:200. (elabscience.com)
  • Chromogranin A can be either measured in the serum or detected by immunohistochemistry in a tissue specimen. (medscape.com)
  • Chromogranin A Positive Control Slides, Product No. 238S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). (sigmaaldrich.com)
  • immunohistochemistry demonstrates chromogranin A, synaptophysin, and usually serotonin and somatostatin positivity (Figure 1, A and B). (thefreedictionary.com)
  • Immunohistochemistry studies using chromogranin and Ki67 markers confirmed the diagnosis. (thefreedictionary.com)
  • Antisera against chromogranin A and B and secretogranin II were used for analysing the bovine pancreas by immunoblotting and immunohistochemistry. (uni-muenchen.de)
  • In immunohistochemistry, chromogranin A was found in all pancreatic endocrine cell types with the exception of most pancreatic polypeptide-(PP-) producing cells. (uni-muenchen.de)
  • Immunogen: C-terminal half of Chromogranin A, purified from urine of patients with carcinoid syndrome. (idhinhibitor.com)
  • Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. (wikipedia.org)
  • Chromogranin A contains multiple cleavage sites, which undergo a tissue-specific proteolytic process, leading to the production of many biologically active peptides including vasostatin I, vasostatin II, pancreastatin, catestatin, parastatin, and serpinin. (medscape.com)
  • Pancreastatin (PST) is one of the chromogranin A (CGA)-derived peptides with known biological activity. (nih.gov)
  • CHGB, also known as secretogranin-1 or chromogranin-B, is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. (creativebiomart.net)
  • Chromogranin A: current status as a precursor for bioactive peptides and a granulogenic/sorting factor in the regulated secretory pathway (1995) Iacangelo Anna L et al. (naver.com)
  • Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant recombinant proteins Most stable storage is at - 81 C or lower but some lyophilised proteins can be stored at +4C. (antibody-antibodies.com)
  • Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Chromogranin_A , 19_457aa, Human, His_tagged, Recombinant, E.coli Source Recombinant. (antibody-antibodies.com)
  • Granins (chromogranins or secretogranins) [ PMID: 2053134 ] are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. (ebi.ac.uk)
  • The chromogranins/secretogranins are a family of acidic, soluble proteins with widespread neuroendocrine distribution in secretory vesicles. (ahajournals.org)
  • Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. (diva-portal.org)
  • A general characteristic for NETs is their expression of certain proteins, such as chromogranin A (CgA), which is released from the dense core vesicles of NE cells, occasionally together with cell specific hormones, such as gastrin and serotonin. (enets.org)
  • Chromogranin A was found in 1967 and is a member of the Granin family, a group of acidic, soluble secretory proteins. (slu.se)
  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (nih.gov)
  • Chromogranin A (CgA) is an acidic secretory glycoprotein found in the secretory granules of neuroendocrine cells and neurons, as is a member of the granin family of proteins. (radiopaedia.org)
  • Full Name: chromogranin A Background: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. (idhinhibitor.com)
  • Chromogranins belong to an evolutionarily conserved family of proteins that serve as neuropeptide proproteins and the secretogranin-II-derived peptide secretoneurin is a 33 amino acid polypeptide that exerts its effects by binding to specific receptors. (ronnyallan.net)
  • The chromogranins comprise a class of acidic proteins that are secreted from large dense core vesicles and expressed in neuronal and endocrine tissues. (elsevier.com)
  • Chromogranin A (CGA) is a member of the granin family of proteins which are widespread in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are typically found in secretory granules. (unicatt.it)
  • Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. (medscape.com)
  • Chromogranin A is a well characterized cancer biomarker and is elevated in adrenal and gastrointestinal neuroendocrine tumors. (biocompare.com)
  • Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours? (endocrine-abstracts.org)
  • Chromogranin A is a molecule whose properties and functions has been investigated extensively, for example its potential as a biomarker. (slu.se)
  • 7 August 2014 - A study, carried out by Chinese researchers and published today in BMC Endocrine Disorders, has demonstrated that Chromogranin A (CgA) is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumours (PNETs) but not for insulinomas. (thefreedictionary.com)
  • The clinical relevance of chromogranin A as a biomarker for gastroentero-pancreatic neuroendocrine tumors. (thefreedictionary.com)
  • Chromogranin A, also known as parathyroid secretory protein 1, or CGA is a secretory protein and a member of the granin family. (biocompare.com)
  • Your search returned 1465 Chromogranin A Antibodies across 57 suppliers. (biocompare.com)
  • Chromogranin A Rabbit-Poly rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
  • Previous studies have indicated that plasma concentrations of chromogranin A (CGA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) are higher in patients with CKD but without cancer, than in healthy individuals, and this can make interpretation of results more complicated. (bibsys.no)
  • Immunohistochemical studies were positive for synaptophysin and CD56 (NCAM), chromogranin A , epithelial antigen, and CAM 5.2/AE-1. (thefreedictionary.com)
  • The chromogranin A (CgA) test is used as a tumor marker. (labcorp.com)
  • El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease. (antikoerper-online.de)
  • Chromogranin A (CgA) is a common marker for endocrine cells. (hindawi.com)
  • Chromogranin A (CgA) is a common marker for these endocrine cells [ 21 - 23 ], and consequently it has been found that CgA is reduced in these patients [ 24 ]. (hindawi.com)
  • Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients. (hindawi.com)
  • Chromogranin A (CgA) is considered to be a common marker for the GI endocrine cells [ 30 - 32 ]. (hindawi.com)
  • Chromogranin A (CgA) is the most important general tumor marker used in the diagnosis and follow-up of patients with neuroendocrine tumors (NET). (enets.org)
  • Serum chromogranin A (CgA) is used as a tumor marker for neuroendocrine tumors (NETs). (enets.org)
  • Chromogranin A (CgA) is the most widely used biochemical tumour marker for NETs, however, its prognostic utility has been questioned due to several non-neuroendocrine causes of elevated CgA. (endocrine-abstracts.org)
  • This is the first study to assess the prognostic utility of chromogranin B (CgB), a marker of NET that is less affected by these clinical drawbacks. (endocrine-abstracts.org)
  • The cases were stained for TTF-1, EMA, low-molecular-weight cytokeratin (CAM 5.2), endothelial cell marker (CD31), surfactant protein B (PE10), and chromogranin A . Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections. (thefreedictionary.com)
  • BACKGROUND Serum chromogranin A (CgA), a marker of neuroendocrine neoplasia, increases during profound gastric acid inhibition, possibly reflecting the trophic effect of gastrin on the enterochromaffin-like (ECL) cells. (semanticscholar.org)
  • Measurement of chromogranin A in porcine saliva: validation of a time-resolved immunofluorometric assay and evaluation of its application as a marker of acute stress. (semanticscholar.org)
  • Chromogranin A is released as hormone in blood and can be used as biochemical marker. (gennovascientific.com)
  • Chromogranin A: is it a useful marker of neuroendocrine tumors? (radiopaedia.org)
  • Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. (fishersci.com)
  • The currently used tumour markers for NETs are neuron-specific enolase (NSE) and chromogranin A (CgA). (elsevier.com)
  • Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. (wikipedia.org)
  • Synthetic peptide corresponding to Human Chromogranin A aa 1-100 (N terminal). (abcam.com)
  • Pancreastatin, a chromogranin A-derived peptide, activates Galpha(16) and phospholipase C-beta(2) by interacting with specific receptors in rat hea. (nih.gov)
  • 1993. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. (biotium.com)
  • Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are poorly understood. (biologists.org)
  • The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA)-positive tumour cells could be demonstrated in breast cancer cases found to be negative by conventional immunohistochemical staining. (sigmaaldrich.com)
  • Detection of chromogranin A in human gastric adenocarcinomas using a sensitive immunohistochemical technique. (sigmaaldrich.com)
  • The two most commonly used immunohistochemical markers for neuroendocrine cells and their tumors are chromogranin A (CgA) and synaptophysin (SPY). (bjbms.org)
  • Clinical significance of elevated serum chromogranin A levels. (radiopaedia.org)
  • Most pituitary adenomas and prolactinomas readily express chromogranin. (sigmaaldrich.com)
  • Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix. (thefreedictionary.com)
  • To identify which segment of CgA (chromogranin A) is important to induce the formation of such granule-like structures, a series of deletion constructs fused to either GFP (green fluorescent protein) or a short epitope tag was expressed in COS-1 fibroblast cells and analysed by fluorescence and electron microscopy and pulse-chase labelling. (portlandpress.com)
  • The diversity of chromogranins sharing common structural features but with possible non-redundant functions implies a variety of secretory granule populations whose existence and function remain to be established in a given neuroendocrine cell type. (springer.com)
  • The present chapter deals with the role of the different members of the chromogranin family in the processes of hormone aggregation, secretory granule biogenesis, and hormone sorting through their interaction with the TGN membrane. (springer.com)
  • Chromogranin A induces and promotes the generation of secretory granules such as those containing insulin in pancreatic islet beta cells. (wikipedia.org)
  • Quantification of chromogranin A may be useful in confirming the diagnosis of a pancreatic NET and assessing for persistent, recurrent, or metastatic disease. (thefreedictionary.com)
  • In September 2001, the patient's serum serotonin and pancreatic polypeptide levels had risen even higher (1,386 ng/ml and 471 pg/ml, respectively), and his serum chromogranin A had more than tripled to 970 ng/ml (figure 4). (thefreedictionary.com)
  • Immunohisto-chemically solid pseudopapillary tumor of pancreas can show overlapping expression of pan CK, synaptophysin, CD56, chromogranin , CD10 and vimentin with neuroendocrine tumors19,20, the expression of neuroendocrine markers with pancreatoblastoma and pancreatic enzymes with acinar cell carcinoma18. (thefreedictionary.com)
  • Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
  • Chromogranin A (a protein of 439-amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (fishersci.com)
  • The purpose of this study is to monitor and validate the performance and stability of the BRAHMS Chromogranin A (CgA) II KRYPTOR Assay in patients with Gastroentero-pancreatic neuroendocrine tumors (GEP-NETs). (mayo.edu)
  • Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets (Langerhans's cells). (gennovascientific.com)
  • Background: Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. (idhinhibitor.com)
  • Tomita T. Significance of chromogranin A and synaptophysin in pancreatic neuroendocrine tumors. (bjbms.org)
  • Chromogranin A, Ki-67 index and IGF-related genes in patients with neuroendocrine tumors. (medscape.com)
  • Fingerprint Dive into the research topics of 'Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Regulation of tumor growth by circulating full-length chromogranin A'. Together they form a unique fingerprint. (elsevier.com)
  • Fingerprint Entra nei temi di ricerca di 'A Critical Approach to Clinical Biochemistry of Chromogranin A'. Insieme formano una fingerprint unica. (unicatt.it)
  • Background- Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. (ahajournals.org)
  • Methods and Results- Gly364Ser heterozygotes and controls underwent physiological and biochemical phenotyping, including catecholamine production, chromogranin A precursor, and its catestatin product. (ahajournals.org)
  • Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi N-W, O'Connor DT, Mahata SK (2012) Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. (springer.com)
  • Chromogranin A (CgA) levels have previously been found to predict mortality in heart failure (HF), but currently no information is available regarding CgA processing in HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function. (uky.edu)
  • Regulation of tumor growth by circulating full-length chromogranin A . Oncotarget , 7 (45), 72716-72732. (elsevier.com)
  • Colombo B, Curnis F, Foglieni C, Monno A, Arrigoni G, Corti A (2002) Chromogranin A expression in neoplastic cells affects tumor growth and morphogenesis in mouse models. (springer.com)
  • Diagnosis can be made by the clinical picture and supported by imaging, endoscopy, or tumor markers such as chromogranin A and serotonin. (thefreedictionary.com)
  • Products to note from this catalog include Euro Diagnostica's gold standard anti-CCP ELISA, ANCA ELISA, Pertusscan ELISA, Complement, as well as endocrine and tumor markers including Chromogranin A and B assays. (thefreedictionary.com)
  • These results establish that chromogranins A and B and secretogranin II are present in the endocrine pancreas, but that they exhibit a distinct cellular localization. (uni-muenchen.de)
  • SNEC showed strong reactivity with epithelial and neuroendocrine markers whereas ENB demonstrated immunoreactivity to synaptophysin and chromogranin strongly, with weak to negative expression of epithelial markers. (thefreedictionary.com)
  • Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. (elsevier.com)
  • Tomita T. Significance of chromogranin A and synaptophysin in medullary thyroid carcinoma: Chromogranin A and synaptophysin in medullary thyroid carcinoma. (bjbms.org)
  • Adrenal system tumors that stain positive for chromogranin A include pheochromocytoma. (medscape.com)
  • Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles of adrenal medulla and sympathetic nerve. (sigmaaldrich.com)
  • Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. (ahajournals.org)
  • The most studied chromogranin is CgA, which was first isolated from chromaffin cells of the adrenal medulla as a single polypeptide chain of 439 amino acids and 10 dibasic cleavage sites. (thefreedictionary.com)
  • Chromogranin A (CGA) is a neurosecretory protein initially identified in bovine adrenal medulla and produced simultaneously with catecholamines (Banks and Helle, 1965). (bioclinica.com)
  • Chromogranin A (CgA), originally identified in adrenal chromaffin cells, is a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. (ovid.com)
  • This protein Belongs to the chromogranin/secretogranin protein family and is expressed in the adrenal medulla, and in pheochromocytoma. (creativebiomart.net)
  • Fluorescence studies of nucleotide interactions with bovine adrenal chromogranin A. (naver.com)
  • Calcium and catecholamine interactions with adrenal chromogranins. (naver.com)
  • Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. (sigmaaldrich.com)
  • This study was designed to assess diagnostic utility of chromogranin A (CgA) alone or in combination with NMN in patients with PHEO/PGL related to mutations in SDHB and SDHD. (cdc.gov)
  • There are several research applications for Chromogranin A measurements for which the assay can be utilized. (alpco.com)
  • The authors want to thank Novartis Pharma AG for their support in providing Chromogranin A assay kits throughout the study. (thefreedictionary.com)
  • There are considerable differences in the amino acid composition between different species' chromogranin A . Commercial assays for measuring human CGA can usually not be used for measuring CGA in samples from other animals. (wikipedia.org)
  • Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound ( 5 ) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. (rsc.org)
  • However, chromogranin A might have some prognostic significance. (medscape.com)
  • Chromogranins are members of a family of soluble glycoproteins sharing common structural features and properties, known to be inducers of prohormone aggregation and sorting into secretory granules. (springer.com)
  • Chromogranin B (CgB) is a soluble secretory protein like chromogranin A (CgA) that has been reported to be elevated in patients with neuroendocrine tumours (NETs) but is not routinely assessed. (enets.org)
  • It belongs to the family of granins that includes chromogranin B, chromogranin C, and secretogranin II. (medscape.com)
  • Work in cell lines has suggested that the most abundant and ubiquitously expressed granins, chromogranin A and B (CgA and CgB), are involved in granulogenesis and protein sorting. (diva-portal.org)
  • Dexamethasone induces an increased biosynthesis of chromogranin A in rat pituitary gland. (naver.com)
  • Tyramide signal amplification discloses chromogranin A-positive tumour cells in more breast tumours than previously realized. (sigmaaldrich.com)
  • Further comparisons of chromogranins with different measures of tumour burden demonstrated that plasma CgB levels were associated with a significant increased risk of disease progression. (endocrine-abstracts.org)
  • Effect of environmental enrichment and herbal compound supplementation on physiological stress indicators (chromogranin A, cortisol and tumour necrosis factor-α) in growing pigs. (semanticscholar.org)
  • Chen Y, Rao F, Rodriguez-Flores JL et al (2008) Naturally occurring human genetic variation in the 3′-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (springer.com)
  • The granin (chromogranin/secretogranin) family. (ebi.ac.uk)
  • Evaluation of psychosomatic stress in children by measuring salivary chromogranin A. (nih.gov)
  • To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction on the suppression of stress in children. (nih.gov)
  • Salivary chromogranin A as a measure of stress response to noise. (semanticscholar.org)
  • Cowley DJ, Moore YR, Darling DS, Joyce PB, Gorr SU (2000) N- and C-terminal domains direct cell type-specific sorting of chromogranin A to secretory granules. (springer.com)
  • Do not freeze taw, rather use Chromogranin A Rabbit-Poly from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
  • Finally, the alteration of chromogranin secretion is described in pathophysiological conditions linked to dysregulated hormone secretion. (springer.com)
  • Chromogranin A: immunohistology reveals its universal occurrence in normal polypeptide hormone producing endocrine glands. (sigmaaldrich.com)
  • Chromogranin A (CgA) is a glycoprotein widely expressed in endocrine and neuroendocrine cells. (alpco.com)
  • Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. (sigmaaldrich.com)
  • The chromogranin A immunoreactivity occurs in the majority of neuroendocrine cells but with variable intensity, length and intracellular distribution. (gennovascientific.com)
  • Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. (weltbild.de)
  • We have also measured plasma chromogranin A concentrations in different groups of patients with hypertension, including those with pheochromocytoma. (ahajournals.org)
  • The Chromoa® Chromogranin A ELISA from Cisbio Bioassays is for the quantitative determination of CgA in serum and plasma. (alpco.com)
  • The Chromoa® Chromogranin A ELISA is a superior method for determining CgA levels in human serum or plasma. (alpco.com)
  • Plasma chromogranin A (CgA) levels are elevated in a variety of neuroendocrine tumors (NETs) and are used to aid in diagnosis, prognosis, and monitoring of treatment effects in NETs patients. (enets.org)
  • In contrast, survival sorted by normal vs abnormal plasma chromogranin A level was not statistically significant (p = 0.24). (cancerstaging.org)
  • Measurement of plasma chromogranin A concentrations for assessment of stress responses in dogs with insulin-induced hypoglycemia. (semanticscholar.org)
  • Plasma androgen receptor and serum chromogranin A in advanced prostate cancer. (cdc.gov)