Chromatin assembly factor 1. Medical search

A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling.

The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.

The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA.

Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.

The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4.

A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.

A retinoblastoma-binding protein that has an affinity for core HISTONES. It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

The process by which a DNA molecule is duplicated.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

The portion of chromosome material that remains condensed and is transcriptionally inactive during INTERPHASE.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

A histone chaperone that facilitates nucleosome assembly by mediating the formation of the histone octamer and its transfer to DNA.

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Proteins involved in the assembly and disassembly of HISTONES into NUCLEOSOMES.

Phase of the CELL CYCLE following G1 and preceding G2 when the entire DNA content of the nucleus is replicated. It is achieved by bidirectional replication at multiple sites along each chromosome.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Proteins found in any species of fungus.

Formation of an acetyl derivative. (Stedman, 25th ed)

A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.

A family of histone molecular chaperones that play roles in sperm CHROMATIN decondensation and CHROMATIN ASSEMBLY in fertilized eggs. They were originally discovered in XENOPUS egg extracts as histone-binding factors that mediate nucleosome formation in vitro.

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.

An enzyme that catalyzes the endonucleolytic cleavage to 3'-phosphomononucleotide and 3'-phospholigonucleotide end-products. It can cause hydrolysis of double- or single-stranded DNA or RNA. (From Enzyme Nomenclature, 1992) EC 3.1.31.1.

The large subunit of the 80s ribosome of eukaryotes. It is composed of the 28S RIBOSOMAL RNA, the 5.8S RIBOSOMAL RNA, the 5S RIBOSOMAL RNA, and about 50 different RIBOSOMAL PROTEINS.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.

Preparations of cell constituents or subcellular materials, isolates, or substances.

Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Established cell cultures that have the potential to propagate indefinitely.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.

An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.

An essential amino acid. It is often added to animal feed.

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.

A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.

A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

Proteins prepared by recombinant DNA technology.

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

An order of anaerobic methanogens in the kingdom EURYARCHAEOTA. They are pseudosarcina, coccoid or sheathed rod-shaped and catabolize methyl groups. The cell wall is composed of protein. The order includes one family, METHANOCOCCACEAE. (From Bergey's Manual of Systemic Bacteriology, 1989)

Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. (1/113)

Chromatin assembly factor 1 (CAF-1) is required for inheritance of epigenetically determined chromosomal states in vivo and promotes assembly of chromatin during DNA replication in vitro. Herein, we demonstrate that after DNA replication, replicated, but not unreplicated, DNA is also competent for CAF-1-dependent chromatin assembly. The proliferating cell nuclear antigen (PCNA), a DNA polymerase clamp, is a component of the replication-dependent marking of DNA for chromatin assembly. The clamp loader, replication factor C (RFC), can reverse this mark by unloading PCNA from the replicated DNA. PCNA binds directly to p150, the largest subunit of CAF-1, and the two proteins colocalize at sites of DNA replication in cells. We suggest that PCNA and CAF-1 connect DNA replication to chromatin assembly and the inheritance of epigenetic chromosome states. (+info)

WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2. (2/113)

Chromatin assembly factor-1 (CAF-1) is essential for chromatin assembly in eukaryotes, and comprises three subunits of 150 kDa (p150), 60 kDa (p60), and 48 kDa (p48). We cloned and sequenced cDNA encoding the small subunit of the chicken CAF-1, chCAF-1p48. It consists of 425 amino acid residues including a putative initiation Met, possesses seven WD repeat motifs, and contains only one amino acid change relative to the human and mouse CAF-1p48s. The immunoprecipitation experiment followed by Western blotting revealed that chCAF-1p48 interacts with chicken histone deacetylases (chHDAC-1 and -2) in vivo. The glutathione S-transferase pulldown affinity assay revealed the in vitro interaction of chCAF-1p48 with chHDAC-1, -2, and -3. We showed that the p48 subunit tightly binds to two regions of chHDAC-2, located between amino acid residues 82-180 and 245-314, respectively. We also established that two N-terminal, two C-terminal, or one N-terminal and one C-terminal WD repeat motif of chCAF-1p48 are required for this interaction, using deletion mutants of the respective regions. These results suggest that chCAF-1p48 is involved in many aspects of DNA-utilizing processes, through alterations in the chromatin structure based on both the acetylation and deacetylation of core histones. (+info)

Chromatin replication: Finding the right connection. (3/113)

Nucleosomes are preferentially assembled on replicating DNA by chromatin assembly factor 1; recent studies have shown that replicated DNA is marked for assembly into chromatin by the replication-fork-associated protein PCNA. (+info)

Chromatin assembly during DNA replication in somatic cells. (4/113)

Newly replicated DNA is assembled into chromatin through two principle pathways. Firstly, parental nucleosomes segregate to replicated DNA, and are transferred directly to one of the two daughter strands during replication fork passage. Secondly, chromatin assembly factors mediate de-novo assembly of nucleosomes on replicating DNA using newly synthesized and acetylated histone proteins. In somatic cells, chromatin assembly factor 1 (CAF-1) appears to be a key player in assembling new nucleosomes during DNA replication. It provides a molecular connection between newly synthesized histones and components of the DNA replication machinery during the S phase of the cell division cycle. (+info)

Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. (5/113)

Mechanisms contributing to the maintenance of heterochromatin in proliferating cells are poorly understood. We demonstrate that chromatin assembly factor 1 (CAF-1) binds to mouse HP1 proteins via an N-terminal domain of its p150 subunit, a domain dispensable for nucleosome assembly during DNA replication. Mutations in p150 prevent association with HP1 in heterochromatin in cells that are not in S phase and the formation of CAF-1-HP1 complexes in nascent chromatin during DNA replication in vitro. We suggest that CAF-1 p150 has a heterochromatin-specific function distinct from its nucleosome assembly function during S phase. Just before mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin concomitant with histone H3 phosphorylation. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated. (+info)

Duplication and maintenance of heterochromatin domains. (6/113)

To investigate the mechanisms that assure the maintenance of heterochromatin regions, we took advantage of the fact that clusters of heterochromatin DNA replicate late in S phase and are processed in discrete foci with a characteristic nuclear distribution. At the light microscopy level, within these entities, we followed DNA synthesis, histone H4 acetylation, heterochromatin protein 1 (Hp1alpha and -beta), and chromatin assembly factor 1 (CAF-1). During replication, Hp1alpha and -beta domains of concentration are stably maintained, whereas heterochromatin regions are enriched in both CAF-1 and replication-specific acetylated isoforms of histone H4 (H4Ac 5 and 12). We defined a time window of 20 min for the maintenance of this state. Furthermore, treatment with Trichostatin A (TSA), during and after replication, sustains the H4Ac 5 and 12 state in heterochromatin excluding H4Ac 8 and 16. In comparison, early replication foci, at the same level, did not display any specific enrichment in H4Ac 5 and 12. These data emphasize the specific importance for heterochromatin of the replication-associated H4 isoforms. We propose that perpetuation of heterochromatin involves self-maintenance factors, including local concentration of Hp1alpha and -beta, and that a degree of plasticity is provided by the cycle of H4 acetylation/deacetylation assisted by CAF-1. (+info)

A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. (7/113)

Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of chromatin in these events is becoming of increasing interest. We show that the presence of single-strand breaks and gaps, formed either directly or during DNA damage processing, can trigger the propagation of nucleosomal arrays. This nucleosome assembly pathway involves the histone chaperone chromatin assembly factor 1 (CAF-1). The largest subunit (p150) of this factor interacts directly with proliferating cell nuclear antigen (PCNA), and critical regions for this interaction on both proteins have been mapped. To isolate proteins specifically recruited during DNA repair, damaged DNA linked to magnetic beads was used. The binding of both PCNA and CAF-1 to this damaged DNA was dependent on the number of DNA lesions and required ATP. Chromatin assembly linked to the repair of single-strand breaks was disrupted by depletion of PCNA from a cell-free system. This defect was rescued by complementation with recombinant PCNA, arguing for role of PCNA in mediating chromatin assembly linked to DNA repair. We discuss the importance of the PCNA-CAF-1 interaction in the context of DNA damage processing and checkpoint control. (+info)

Distinct importin recognition properties of histones and chromatin assembly factors. (8/113)

Synthesis of the protein components of nuclear chromatin occurs in the cytoplasm, necessitating specific import into the nucleus. Here, we report the binding affinities of the nuclear localisation sequence (NLS)-binding importin subunits for a range of histones and chromatin assembly factors. The results suggest that import of histones to the nucleus may be mediated predominantly by importin beta1, whereas the import of the other components probably relies on the conventional alpha/beta1 import pathway. Differences in recognition by importin beta1 were observed between histone H2A and the variant H2AZ, as well as between histone H3/4 with or without acetylation. The results imply that different histone variants may possess distinct nuclear import properties, with acetylation possibly playing an inhibitory role through NLS masking. (+info)

Mitochondrial diseases can affect anyone, regardless of age or gender, and they can be caused by mutations in either the mitochondrial DNA (mtDNA) or the nuclear DNA (nDNA). These mutations can be inherited from one's parents or acquired during embryonic development.

Some of the most common symptoms of mitochondrial diseases include:

1. Muscle weakness and wasting
2. Seizures
3. Cognitive impairment
4. Vision loss
5. Hearing loss
6. Heart problems
7. Neurological disorders
8. Gastrointestinal issues
9. Liver and kidney dysfunction

Some examples of mitochondrial diseases include:

1. MELAS syndrome (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes)
2. Kearns-Sayre syndrome (a rare progressive disorder that affects the nervous system and other organs)
3. Chronic progressive external ophthalmoplegia (CPEO), which is characterized by weakness of the extraocular muscles and vision loss
4. Mitochondrial DNA depletion syndrome, which can cause a wide range of symptoms including seizures, developmental delays, and muscle weakness.
5. Mitochondrial myopathy, encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
6. Leigh syndrome, which is a rare genetic disorder that affects the brain and spinal cord.
7. LHON (Leber's Hereditary Optic Neuropathy), which is a rare form of vision loss that can lead to blindness in one or both eyes.
8. Mitochondrial DNA mutation, which can cause a wide range of symptoms including seizures, developmental delays, and muscle weakness.
9. Mitochondrial myopathy, encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
10. Kearns-Sayre syndrome, which is a rare progressive disorder that affects the nervous system and other organs.

It's important to note that this is not an exhaustive list and there are many more mitochondrial diseases and disorders that can affect individuals. Additionally, while these diseases are rare, they can have a significant impact on the quality of life of those affected and their families.

"Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1". Nucleic Acids ... Chromatin assembly factor-1 (CAF-1) is a protein complex - including Chaf1a (p150), Chaf1b (p60), and p48 subunits in humans, ... Wang Z, Wu R, Nie Q, Bouchonville KJ, Diasio RB, Offer SM (March 2021). "Chromatin assembly factor 1 suppresses epigenetic ... Hoek M, Stillman B (October 2003). "Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication ...

https://en.wikipedia.org/wiki/Chromatin_assembly_factor_1

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene. Chromatin assembly factor I ( ... "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)". Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, ... Nabatiyan A, Krude T (Apr 2004). "Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of ... Shim KS, Bergelson JM, Furuse M, Ovod V, Krude T, Lubec G (2004). "Reduction of chromatin assembly factor 1 p60 and C21orf2 ...

https://en.wikipedia.org/wiki/CHAF1B

"Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759-68. doi:10.1128/MCB. ... Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene. HBXAP is involved in transcription ... "Entrez Gene: RSF1 remodeling and spacing factor 1". Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts ... LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in ...

https://en.wikipedia.org/wiki/RSF1

... major roles in chromatin decondensation and nuclear assembly". J. Cell Biol. 158 (3): 475-85. doi:10.1083/jcb.200202019. PMC ... Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene. It is a member of the barrier-to- ... Barrier to autointegration factor 1 has been shown to interact with Thymopoietin. Mutations in this gene have been shown to ... 2006). "Cellular co-factors of HIV-1 integration". Trends Biochem. Sci. 31 (2): 98-105. doi:10.1016/j.tibs.2005.12.002. PMID ...

https://en.wikipedia.org/wiki/Barrier_to_autointegration_factor_1

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene. Chromatin assembly factor I ( ... "Entrez Gene: CHAF1A chromatin assembly factor 1, subunit A (p150)". Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, ... Kaufman PD, Kobayashi R, Kessler N, Stillman B (August 1995). "The p150 and p60 subunits of chromatin assembly factor I: a ... interaction between chromatin assembly factor 1 and HP1 proteins". Mol. Cell. 4 (4): 529-40. doi:10.1016/S1097-2765(00)80204-X ...

https://en.wikipedia.org/wiki/CHAF1A

"Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function". Molecular and ... Apoptotic factors ATPases Base excision repair enzymes Cell-cycle regulators Chromatin remodeling factor Clamp loader Cohesin ... PCNA is also found in archaea, as a processivity factor of polD, the single multi-functional DNA polymerase in this domain of ... PCNA is clamped to DNA through the action of replication factor C (RFC), which is a heteropentameric member of the AAA+ class ...

https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen

"Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1". Mol. Cell. 7 (1): 13-20. doi: ... cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in ... Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene. The protein encoded by ... Takagaki Y, Manley JL (1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J. Biol. Chem. 267 (33): ...

https://en.wikipedia.org/wiki/CSTF3

... interaction between chromatin assembly factor 1 and HP1 proteins". Molecular Cell. 4 (4): 529-40. doi:10.1016/S1097-2765(00) ... a potential role in the regulation of higher-order chromatin structure". The Journal of Pathology. 196 (2): 135-44. doi:10.1002 ... Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene. The protein is localized at ... 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015. van der Weyden L, White JK, Adams DJ, Logan DW ( ...

https://en.wikipedia.org/wiki/CBX1

... interaction between chromatin assembly factor 1 and HP1 proteins". Molecular Cell. 4 (4): 529-40. doi:10.1016/S1097-2765(00) ... "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Molecular and Cellular ... "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". The ... "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". ...

https://en.wikipedia.org/wiki/CBX5_(gene)

"The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 23 (9): ... "The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 23 (9): ... Assembly of novel secondary chromatin structures in the absence of DNA methylation". J. Biol. Chem. 278 (34): 32181-8. doi: ... Ueba T, Kaspar B, Zhao X, Gage FH (1999). "Repression of human fibroblast growth factor 2 by a novel transcription factor". J. ...

https://en.wikipedia.org/wiki/MBD1

Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases ... "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068- ... are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM] ... Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular ...

https://en.wikipedia.org/wiki/TLK1

Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases ... Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases ... are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different ... 202 (1-2): 193-201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565. Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA ( ...

https://en.wikipedia.org/wiki/TLK2

Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases ... "Transcriptional regulation of human chromatin assembly factor ASF1". DNA and Cell Biology. 26 (2): 91-9. doi:10.1089/dna. ... in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. ... Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular ...

https://en.wikipedia.org/wiki/ASF1B

It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair ... Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases ... "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068- ... Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M (Mar 2000). "A human homologue of yeast anti-silencing factor has ...

https://en.wikipedia.org/wiki/ASF1A

Nair SS, Li DQ, Kumar R (February 2013). "A core chromatin remodeling factor instructs global chromatin signaling through ... "G9a inhibits MEF2C activity to control sarcomere assembly". Scientific Reports. 6 (1): 34163. Bibcode:2016NatSR...634163O. doi: ... For example, G9A/GLP can methylate a number of transcription factors to regulate their transcriptional activity, including MyoD ... January 2012). "Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle ...

https://en.wikipedia.org/wiki/EHMT1

Proteins RbAp48 is a key player in the assembly of nucleosomes. RbAp48 protein is a subunit of the chromatin-assembly factor-1 ... a human cell factor required for chromatin assembly during DNA replication in vitro". Cell. 58 (1): 15-25. doi:10.1016/0092- ... Chromatin function and acetylation A direct link between chromatin function and acetylation was established by the discovery ... interacts with H3-H4 dimers and imply that the function of RbAp48 is involved in numerous process such as chromatin assembly, ...

https://en.wikipedia.org/wiki/Deficiency_of_RbAp48_protein_and_memory_loss

... and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1". ... 256 (1): 225-36. doi:10.1006/excr.1999.4778. PMID 10739669. Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, ... 75 (1): 104-8. doi:10.1002/(SICI)1096-8628(19980106)75:1. 3.0.CO;2-P. PMID 9450867. "Entrez Gene: TOP3A topoisomerase (DNA) III ...

https://en.wikipedia.org/wiki/TOP3A

... and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1". ... 46 (1): 43-53. doi:10.1016/j.molcel.2012.02.020. PMC 3328772. PMID 22500736. Séguéla-Arnaud M, Crismani W, Larchevêque C, Mazel ... Sharma S, Sommers JA, Wu L, Bohr VA, Hickson ID, Brosh RM (March 2004). "Stimulation of flap endonuclease-1 by the Bloom's ... doi:10.1016/0092-8674(95)90105-1. PMID 7585968. S2CID 13439128. German J, Roe AM, Leppert MF, Ellis NA (1994). "Bloom syndrome ...

https://en.wikipedia.org/wiki/Bloom_syndrome_protein

The heterotrimeric chaperone chromatin assembly factor 1 (CAF-1) is a chromatin formation protein that is involved in ... "Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function". Molecular and ... The chromatin licensing and DNA replication factor 1 (Cdt1) protein is required for the licensing of chromatin for DNA ... The assembly of the Mcm proteins onto chromatin requires the coordinated function of the origin recognition complex (ORC), Cdc6 ...

https://en.wikipedia.org/wiki/Eukaryotic_DNA_replication

"The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating ... Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in ... "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. ... 327 (1): 111-28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). " ...

https://en.wikipedia.org/wiki/DBF4

"The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating ... After chromatin undergoes changes in telophase of mitosis, the hexameric protein complex of MCM proteins 2-7 forms part of the ... Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in ... Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast ...

https://en.wikipedia.org/wiki/Cell_division_cycle_7-related_protein_kinase

CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a ... The protein encoded by this gene is a key licensing factor in the assembly of pre-replication complexes (pre-RC), which occurs ... "Entrez Gene: CDT1 chromatin licensing and DNA replication factor 1". "CDT1 gene". Genetics Home Reference. Retrieved 2018-07-19 ... In the assembly of pre-RCs, origin recognition complexes (ORC1-6) recognize and bind to DNA replication origins. CDT1, along ...

https://en.wikipedia.org/wiki/DNA_replication_factor_CDT1

Chromatin assembly factor-1) - histone chaperone that execute a coordinating role in сhromatin remodeling. Teif VB, Rippe K ( ... The ISWI-family remodelers have been shown to play central roles in chromatin assembly after DNA replication and maintenance of ... Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the ... Epigenetics Histone Nucleosomes Chromatin Histone acetyltransferase Transcription factors CAF-1 ( ...

https://en.wikipedia.org/wiki/Chromatin_remodeling

Kaufman PD, Kobayashi R, Kessler N, Stillman B (June 1995). "The p150 and p60 subunits of chromatin assembly factor I: a ... They are assembled by the chromatin assembly factor-1 (CAF-1) complex, which consists of three subunits (p150, p60, and p48). ... April 2006). "Modifications of H3 and H4 during chromatin replication, nucleosome assembly, and histone exchange". The Journal ... April 2005). "Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly". Molecular Cell. ...

https://en.wikipedia.org/wiki/Nucleosome

Makde R, England J, Yennawar H, Tan S (2010). "Structure of the RCC1 chromatin factor bound to the nucleosome core particle". ... The gradient triggers release of spindle assembly factors (SAFs) from inhibitory interactions via the transport proteins ... and yeast are required for proper spindle assembly; in mammals, CLASP1 and CLASP2 both contribute to proper spindle assembly ... Thus, a gradient of GTP-bound Ran is generated around the vicinity of mitotic chromatin. Glass beads coated with RCC1 induce ...

https://en.wikipedia.org/wiki/Spindle_apparatus

... and news Protocol for in vitro Chromatin Assembly ENCODE threads Explorer Chromatin patterns at transcription factor binding ... Other factors are probably involved, such as the association and dissociation of transcription factor complexes with chromatin ... In eukaryotes, ATP-dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed ... When the chromatin decondenses, the DNA is open to entry of molecular machinery. Fluctuations between open and closed chromatin ...

https://en.wikipedia.org/wiki/Chromatin

ACF (for ATP-utilising chromatin assembly and remodeling factor) is a chromatin-remodeling complex that catalyzes the ATP- ... ATP-dependent chromatin assembly factor large subunit Acf1 human - WSTF (Williams syndrome transcription factor) mouse - cbp146 ... "Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly". Mol. Cell. Biol. 22 (18): ... that function cooperatively in the ATP-dependent catalysis of chromatin assembly". Genes Dev. 13 (12): 1529-39. doi:10.1101/gad ...

https://en.wikipedia.org/wiki/WAC_protein_domain

... to study DNA replication-coupled chromatin assembly in a test tube and discovered proteins such as Chromatin Assembly Factor-1 ... The proteins that combine with DNA to organize the genome into a chromatin structure include histones. He developed a ... Waga, S.; Bauer, G.; Stillman B. (1994). "Reconstitution of complete SV40 DNA replication with purified replication factors". ... These studies resulted in understanding how chromatin is inherited. Commonwealth Postgraduate Award (1976-1978) Damon Runyon- ...

https://en.wikipedia.org/wiki/Bruce_William_Stillman

... chromatin assembly factor-1), a protein complex maintaining chromatin Conductive anodic filament, an electrochemical migration- ... type failure in printed circuit boards Central African Republic, by ISO 3166-1 country code Common Assessment Framework, an EU ...

https://en.wikipedia.org/wiki/CAF

Four transcription factor-like proteins have been found in PBSV-1, including TFIIB (A107L), TFIID (A552R), TFIIS (A125L), and a ... The second phase of proteins are translated in the cytoplasm and the assembly of virus capsids begins about 2-3 hours post ... The HaV virus, infecting H. akashiwo has been shown to be a factor in bloom termination. Suttle et al. (1990) suggested that ... The eukaryotic replication factor C". European Journal of Biochemistry. 254 (2): 209-216. doi:10.1046/j.1432-1327.1998.2540209. ...

https://en.wikipedia.org/wiki/Phycodnaviridae

"The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis". ... it acts as a CAD inhibitor and also as a chaperone for CAD synthesis assisting the correct assembly of the protein. ICAD has ... DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for ... The factor that seems to induce more cell differentiation is caspase-3 protease. This was identified as the penultimate stage ...

https://en.wikipedia.org/wiki/Caspase-activated_DNase

"Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres ... The omnipresence of Daxx in the cell nucleus suggests that the protein may also function as a transcription factor. Although it ... Proteins other than transcription factors are also blocked or inhibited by Daxx, such as the TGF-β pathway regulator, Smad4, ... It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor ...

https://en.wikipedia.org/wiki/Death-associated_protein_6

The expression profiles of these transcription factors are driven by the transcription factors that peak in the prior phase, ... chromatin, etc.). An unhealthy or malnourished cell will get stuck at this checkpoint. The G2/M checkpoint is where the cell ... the initiation of mitosis by stimulating downstream proteins involved in chromosome condensation and mitotic spindle assembly. ... One screen of single-gene knockouts identified 48 transcription factors (about 20% of all non-essential transcription factors) ...

https://en.wikipedia.org/wiki/Cell_cycle

This type of regulation can occur in different ways: the RNA transcript can directly bind to the transcription factor as a co- ... In addition to directly affecting chromatin structure, there are a number of ways in which SINEs can potentially regulate gene ... two types of RNA vital to ribosomal assembly and mRNA translation. SINEs, like tRNAs and many small-nuclear RNAs possess an ... These non-coding RNAs, which lie adjacent to or overlap gene-sets provide a mechanism by which transcription factors and ...

https://en.wikipedia.org/wiki/Short_interspersed_nuclear_element

Wallberg AE, Neely KE, Hassan AH, Gustafsson JA, Workman JL, Wright AP (March 2000). "Recruitment of the SWI-SNF chromatin ... However activated GR can complex with these other transcription factors and prevent them from binding their target genes and ... Lerner L, Henriksen MA, Zhang X, Darnell JE (October 2003). "STAT3-dependent enhanceosome assembly and disassembly: synergy ... Song CZ, Tian X, Gelehrter TD (October 1999). "Glucocorticoid receptor inhibits transforming growth factor-beta signaling by ...

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

However, all other transcription factors in the MSL family-maleless, MSL-1, and MSL-3-are able to act when SXL is not expressed ... A study using a combination of methods (Hi-C assembly, coverage analysis and ChIp-seq) found that the neo-Z segment exhibits ... Cock A.G. (1964). "Dosage compensation and sex-chromatin in non-mammals". Genet Res Camb. 5 (3): 354-365. doi:10.1017/ ... These factors act to increase male X chromosome transcriptional activity. Histone acetylation and the consequent upregulation ...

https://en.wikipedia.org/wiki/Sex-chromosome_dosage_compensation

However, the GTP bound to β-tubulin may be hydrolyzed to GDP shortly after assembly. The assembly properties of GDP-tubulin are ... Signals sent between the follicular cells and the oocyte (such as factors similar to epidermal growth factor) cause the ... RAN-GTP associates with chromatin during mitosis to create a gradient that allows for local nucleation of microtubules near the ... A wide variety of drugs are able to bind to tubulin and modify its assembly properties. These drugs can have an effect at ...

https://en.wikipedia.org/wiki/Microtubule

Assembly of the pre-replication complex only occurs during late M phase and early G1 phase of the cell cycle when cyclin- ... Cdc6 recruits the licensing factor Cdt1 and MCM2-7. Cdt1 binding and ATP hydrolysis by the ORC and Cdc6 load MCM2-7 onto DNA. ... and dissociating ORC1-6 from chromatin via phosphorylation. Prevention of re-replication in S. pombe is slightly different; ... Assembly of the pre-RC relies on prior origin recognition, either by DnaA in prokaryotes or by ORC in archaea and eukaryotes. ...

https://en.wikipedia.org/wiki/Pre-replication_complex

"2 Chromatin patterns at transcription factor binding sites". Nature: 1. 2019. doi:10.1038/nature28171. (Articles with short ... April 2018). "Nanopore sequencing and assembly of a human genome with ultra-long reads". Nature Biotechnology. 36 (4): 338-345 ... Chromatin packaging of DNA varies depending on the cell cycle stage and by local DNA region. The degree to which chromatin is ... However instead of isolating a DNA-binding transcription factor or enhancer protein through chromatin immunoprecipitation, the ...

https://en.wikipedia.org/wiki/Epigenomics

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1). Nuclear ... Fryer CJ, Archer TK (1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature. 393 (6680 ... "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 ...

https://en.wikipedia.org/wiki/Nuclear_receptor_coactivator_2

Nagai S, Davis RE, Mattei PJ, Eagen KP, Kornberg RD (2017). "Chromatin potentiates transcription". Proc Natl Acad Sci U S A. ... Thus, the structure of a mediator complex can be augmented by RNA as well as proteinaceous transcription factors. Mediator was ... "Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly". PLOS Biology. 9 (3): e1000603. doi:10.1371/ ... In addition to RNA polymerase II, mediator must also associate with transcription factors and DNA. A model of such interactions ...

https://en.wikipedia.org/wiki/Mediator_(coactivator)

The complexes formed by the looping of the DNA are known as chromatin. The basic structural unit of chromatin is the nucleosome ... Maruta H, Greer K, Rosenbaum JL (1986). "The acetylation of alpha-tubulin and its relationship to the assembly and disassembly ... The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and ... Chromatin states were investigated in Drosophila cells by looking at the binding location of proteins in the genome. Use of ...

https://en.wikipedia.org/wiki/H4K8ac

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly ... Holthoff HP, Baack M, Richter A, Ritzi M, Knippers R (1998). "Human protein MCM6 on HeLa cell chromatin". J. Biol. Chem. 273 ( ... Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast ... Mattar R, de Campos Mazo DF, Carrilho FJ (2012). "Lactose intolerance: diagnosis, genetic, and clinical factors". Clin Exp ...

https://en.wikipedia.org/wiki/MCM6

Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (March 1999). "A novel ubiquitination factor, E4, is involved in ... Michel MA, Elliott PR, Swatek KN, Simicek M, Pruneda JN, Wagstaff JL, Freund SM, Komander D (April 2015). "Assembly and ... Histone ubiquitination alters chromatin structure and allows the access of enzymes involved in transcription. Ubiquitin on ... A heat-stable polypeptide present in these extracts, ATP-dependent proteolysis factor 1 (APF-1), was found to become covalently ...

https://en.wikipedia.org/wiki/Ubiquitin

Zhao ZS, Manser E, Loo TH, Lim L (September 2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal ... a role in cytoskeletal assembly". The Journal of Cell Biology. 119 (4): 893-903. doi:10.1083/jcb.119.4.893. PMC 2289706. PMID ... which involves contracting the cortical actin ring and is followed by chromatin condensation and nuclear fragmentation. ... Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD (May 2000). "FAK integrates growth-factor and ...

https://en.wikipedia.org/wiki/PTK2

"The transcription factor PAX5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells". EMBO ... 11,183,530-11,382,580 in the GRCh37 assembly, or 6:11,183,298-11,382,348 in the GRCh38 assembly. The gene is on the minus ... The Fox transcription factor Forkhead box C1 (FoxC1) and PAX5 transcription factor have been reported to induce NEDD9 ... NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. ...

https://en.wikipedia.org/wiki/NEDD9

Detection of genome-wide effects: Changes in global regulators including chromatin remodelers, transcription factors (e.g., MYC ... assembly quality can vary depending on which metric is used, 2) assembly tools that scored well in one species do not ... Metrics to assess the quality of a de novo assembly include median contig length, number of contigs and N50. Genome guided: ... Expression is quantified by counting the number of reads that mapped to each locus in the transcriptome assembly step. ...

https://en.wikipedia.org/wiki/RNA-Seq

In the budding yeast, initial cell cycle entry is controlled by two regulatory complexes, SBF (SCB-binding factor) and MBF (MCB ... Finally, phosphorylation by M cyclins (e.g., Clb1, 2, 3 and 4) in complex with Cdk1 leads to spindle assembly and sister ... "Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein". J. Biol. ... Dutta A, Stillman B (1992). "cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA ...

https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_1

... targeting the transcription factor brain-derived neurotrophic factor (BDNF) and ultimately reducing its expression. BDNF plays ... Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD (October 2003). "Asymmetry in the assembly of the RNAi enzyme complex ... "Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer". FEBS Letters. 574 (1-3): 1-8. doi: ... Lin SL, Chang D, Ying SY (August 2005). "Asymmetry of intronic pre-miRNA structures in functional RISC assembly". Gene. 356: 32 ...

https://en.wikipedia.org/wiki/MicroRNA

In eukaryotes, ATP dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed ... "RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins". Cell. 131 (5): 887-900. doi: ... December 2016). "The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage". ... The extent of chromatin with phosphorylated γH2AX is about two million base pairs at the site of a DNA double-strand break. ...

https://en.wikipedia.org/wiki/DNA_repair

... a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of ... Dantuma NP, Acs K, Luijsterburg MS (November 2014). "Should I stay or should I go: VCP/p97-mediated chromatin extraction in the ... The ATPase activity of p97 can be influenced by many factors. For example, it can be stimulated by heat or by a putative ... The p97 hexameric assembly can undergo dramatic conformational changes during nucleotide hydrolysis cycle, and it is generally ...

https://en.wikipedia.org/wiki/Valosin-containing_protein

... plus histone and chromatin modifying factors. In certain circumstances, the MMR pathway may recruit an error-prone DNA ... Heller RC, Marians KJ (December 2006). "Replisome assembly and the direct restart of stalled replication forks". Nature Reviews ... The histone modification H3K36me3, an epigenetic mark of active chromatin, has the ability to recruit the MSH2-MSH6 (hMutSα) ... Li GM (July 2014). "New insights and challenges in mismatch repair: getting over the chromatin hurdle". DNA Repair. 19: 48-54. ...

https://en.wikipedia.org/wiki/DNA_mismatch_repair

Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin- ... Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule ... 95 (1): 96-8. doi:10.1007/BF00225082. PMID 7814034. S2CID 902030. v t e (Genes on human chromosome 12, Human proteins, All stub ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...

https://en.wikipedia.org/wiki/NEDD1

UAP56 is recognized as an RNA helicase but acts as a splicing factor required for early spliceosome assembly. Another factor ... by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin- ... It is organized around the eIF4AIII factor. The factor itself consists of two different types of conformations around the mRNA ... The core of the EJC contains the protein eukaryotic initiation factor 4A-III (eIF4A-III; a DEAD-box RNA helicase) bound to an ...

https://en.wikipedia.org/wiki/Exon_junction_complex

The spindle assembly checkpoint (SAC) is a molecular safe-guarding mechanism that governs proper chromosome segregation in ... Other studies indicate factors such as alcohol consumption, occupational exposure to benzene, and exposure to the insecticides ... This is known as a chromatin bridge or an anaphase bridge. Mitotic nondisjunction results in somatic mosaicism, since only ... Sun, S.-C.; Kim, N.-H. (14 November 2011). "Spindle assembly checkpoint and its regulators in meiosis". Human Reproduction ...

https://en.wikipedia.org/wiki/Nondisjunction

Condensed chromatin, heterochromatin, prevents transcription of genes. In other words, transcription factors cannot access ... The term has also been used to describe the hierarchical assembly of artificial nucleic acid building blocks used in DNA ... The quaternary structure of DNA refers to the formation of chromatin. Because the human genome is so large, DNA must be ... May 2011). "Structure and assembly of the essential RNA ring component of a viral DNA packaging motor". Proceedings of the ...

https://en.wikipedia.org/wiki/Nucleic_acid_quaternary_structure

"The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 ... An example of this is the binding of tumour necrosis factor-alpha (TNF-alpha) to TNF-alpha receptor. An example of a TNF ... During prophase, as the chromatin condenses so that it is visible under the microscope, survivin starts to move to the ... Instead, it is observed that modification of the chromatin inside of the promoter region may be responsible for the ...

https://en.wikipedia.org/wiki/Survivin

Four epigenetic processes have been well described: chromatin assembly, histone modifications, DNA methylation, and regulatory ... These drugs since have been developed commercially and are subsequently prescribed depending on factors such as the immune ... advancements in chromatin-based viral therapy relies on advancement in knowledge of viral-host chromatin dynamics and interplay ... The HSV genome is then injected into the nucleus where it is assembled with histones and undergoes chromatin remodeling, thus ...

https://en.wikipedia.org/wiki/HSV_epigenetics

Order Recombinant Chromatin Assembly Factor 1 Subunit B CHAF1B 04012503103 at Gentaur Chromatin Assembly Factor 1, Subunit B ( ... Name: Recombinant Chromatin Assembly Factor 1, Subunit B (CHAF1B) Price: 835.00 Size: 200 μg Catalog number: RPU53254 ... Chromatin Assembly Factor I,p60 subunit; M-phase phosphoprotein 7. Protein origin. E.coli. Protein region. Please contact us.. ... Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of ...

http://chromatine.com/catalog-list/2354-bioma/4133-recombinant-chromatin-assembly-factor-1-functionnal-sequence-b-chaf1b

Chromatin assembly factor 1 subunit A (CHAF1A) was highly correlated with proliferating cell nuclear antigen (PCNA) expression ... Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of ... DNA replication; chromatin assembly factor 1 subunit A; esophageal cancer; prognostic marker; proliferating cell nuclear ... Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Anti ...

https://pesquisa.bvsalud.org/controlecancer/resource/pt/mdl-37189802

In budding yeast, evolutionarily conserved histone chaperones Scm3 and chromatin assembly factor-1 (CAF-1) promote localization ... Keywords: Budding yeast; CENP-A; Centromere; Chromatin assembly factor-1; Cse4; Kinetochore; Psh1; Saccharomyces cerevisiae; ... Insights into assembly and regulation of centromeric chromatin in Saccharomyces cerevisiae. Choy JS, Mishra PK, Au WC, Basrai ... B) Levels of chromatin bound Cse4. were quantified after normalization to H3 levels in the chromatin in three independent ...

https://www.ncbi.nlm.nih.gov/pubmed/32111629

Localization: Chromatin Assembly Factor 1, Excitation: 399, Emission: 456. Depositor Michael Davidson ...

https://www.addgene.org/search/catalog/plasmids/?q=mTagBFP2

Loss of the chromatin modifier chromatin assembly factor 1 subunit p150 (CHAF1A) promotes NB cell differentiation; however, the ... Chromatin Assembly Factor-1/metabolism*; Female; Gene Expression Regulation, Neoplastic/genetics; Humans; Male; Mice; Mice, ... Chromatin Assembly Factor-1/genetics; ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=4365480

Transcriptional regulation of human chromatin assembly factor ASF1.. Hayashi R; Goto Y; Tanaka R; Oonogi K; Hisasue M; Yoshida ... 4. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation ... Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1.. Zhou D; Masri S; Ye JJ; Chen S ... Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=17328667&mod=related&page=1&outid=&proj=

Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to ... CIA (CCG1-interacting factor A)/ASF1, which is the most conserved histone chaperone among the eukaryotes, was genetically ... promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci ( ... Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M. A human homologue of yeast anti-silencing factor has histone ...

https://proteopedia.org/wiki/index.php/2io5

... is also a component of several other protein complexes involved in chromatin remodeling.. Terms. Chromatin Assembly Factor-1 ... Chromatin Assembly Factor-1 Preferred Concept UI. M0527523. Registry Number. 0. Scope Note. A histone chaperone protein that ... Chromatin Assembly Factor-1 [D12.776.580.219.200] * Retinoblastoma-Binding Protein 4 [D12.776.580.219.200.500] ... 2010; CHROMATIN ASSEMBLY FACTOR-1 was indexed under CHROMOSOMAL PROTEINS, NON-HISTONE and DNA-BINDING PROTEINS 1995-2009. ...

https://meshb.nlm.nih.gov/record/ui?ui=D056504

chromatin assembly factor I p48 subunit. *chromatin assembly factor/CAF-1 p48 subunit ... It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which ... has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded ... chromatin assembly factor 1 subunit C. * ... Chromatin assembly factor I p48 subunit. *MSI1 protein homolog ...

https://edrn.nci.nih.gov/data-and-resources/biomarkers/rbbp4/

Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly.. Segura-Totten M, Kowalski AK ... Phone: +1-800-860-8747 TTY: +711 Chat. Live Chat Available. 8:30 a.m - 5 p.m. ET. Monday - Friday ... The road to chromatin - nuclear entry of retroviruses.. Suzuki Y, Craigie R.. Nat Rev Microbiol (2007 Mar) 5:187-96. Abstract/ ... Barrier-to-autointegration factor (BAF) condenses DNA by looping.. Skoko D, Li M, Huang Y, Mizuuchi M, Cai M, Bradley CM, Pease ...

https://www.niddk.nih.gov/about-niddk/staff-directory/biography/craigie-robert/publications

The Ran-GTP gradient guides mitotic spindle assembly by releasing spindle assembly factors (SAFs) from karyopherins based on ... RanBP1 complex formation competes with chromatin binding to regulate the distribution of RCC1 between the chromatin-associated ... nuclear envelope assembly, and mitotic spindle assembly. Ran alternates between GDP- and GTP-bound forms. In interphase cells, ... In cells, the conversion of Ran-GDP to Ran-GTP is catalyzed by a Ran-specific guanine exchange factor called RCC1 (regulator of ...

https://www.nichd.nih.gov/research/atNICHD/Investigators/dasso/research

Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds ... A CAR-RXR heterodimer has thus been characterized as a trans-acting factor for the phenobarbital-inducible Cyp2b10 gene. ... 1 Functional assays to define the NR1 site as a DR4 motif. (A) The 51-bp enhancer-tk-CAT plasmids of the spacing and mutation ... Liver nuclear extracts (1 mg of proteins in 1 ml of the incubation mixture) from the PB-treated mice at each time point (1 to ...

https://pubmed.ncbi.nlm.nih.gov/9742082/

Chromatin Assembly Factor-1 - Preferred Concept UI. M0527523. Scope note. A histone chaperone protein that plays a role in the ... Chromatin Assembly Factor-1 Entry term(s). Assembly Complex-1, Chromatin Assembly Factor-1, Chromatin Chromatin Assembly ... 2010; CHROMATIN ASSEMBLY FACTOR-1 was indexed under CHROMOSOMAL PROTEINS, NON-HISTONE and DNA-BINDING PROTEINS 1995-2009. ... Chromatin Assembly Complex-1, p150 Subunit - Narrower Concept UI. M0527547. Preferred term. Chromatin Assembly Complex-1, p150 ...

https://decs.bvsalud.org/en/ths/resource/?id=53653

https://meshb-prev.nlm.nih.gov/record/ui?ui=D056504

Chromatin Assembly Factor 1 Research Area Fluorescent Cell Imaging References. There are 0 reference entries for this reagent. ...

https://ximbio.com/reagent/157442/egfp-caf1-c-6-vector

... p150Chromatin assembly factor 1 complex p150 subunit, N-terminal. 15.270 MARCKSMARCKS family. ... Pfam description : Brain acid soluble protein 1 (BASP1 protein). Click here to go to the Pfam web-site for this family ...

http://supfam.mbu.iisc.ernet.in/CGI/display_pfam.cgi?name=BASP1

The VRK1 gene provides instructions for making a protein called VRK serine/threonine kinase 1. Learn about this gene and ... Chromatin is the complex of DNA and protein that packages DNA into chromosomes. Both the assembly of the nuclear envelope and ... This protein regulates several transcription factors, which are proteins that control the activity of genes by attaching ( ... This protein is involved in the assembly of the nuclear envelope, which is a structure that surrounds the nucleus and acts as a ...

https://medlineplus.gov/genetics/gene/vrk1/

The mechanisms by which transcription factors, chromatin features, or other relevant proteins and RNAs interact with or ... chromatin organization, but details of their assembly and biological function are lacking. Understanding of the exact role ... Defining chromatin interactions and the ways in which nuclear architecture constrains/enables interactions, and describing the ... These include nucleoli, Cajal bodies (CBs), Polycomb group (PcG) bodies, splicing factor compartments, paraspeckles, ...

https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-008.html

chromatin assembly factor 1 subunit c, putative; caf1c; rbap48. 9078. PF3D7_1224500. histone chaperone ASF1. ... pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative. R.NTVSEECTYSTNER.T. ... polyadenylate-binding protein-interacting protein 1, putative. K.SIDALTENENNKNDAECSDSTTVK.N K.SCVSSLGVETNMK.N. ...

https://mpmp.huji.ac.il/maps/nitrosylatedProt.html

chromatin assembly factor 1, subunit B (p60) ENSMUSG00000022945 Q9D0N7 Chd7 chromodomain helicase DNA binding protein 7 ... general transcription factor II A, 2 ENSMUSG00000033543 Q80ZM7 Gtf2f1 general transcription factor IIF, polypeptide 1 ... negative elongation factor complex member B, Cobra1 ENSMUSG00000013465 Q8C4Y3 Nfkbia nuclear factor of kappa light polypeptide ... RRN3 RNA polymerase I transcription factor homolog (yeast) ENSMUSG00000022682 B2RS91 Safb scaffold attachment factor B ...

https://esbl.nhlbi.nih.gov/Databases/KSBP2/Targets/Lists/Co-Regulators/

12. Transcription and Preinitiation Complex Assembly In Vitro. 13. Studying Chromatin Dynamics In Vitro: Chromatin Assembly, ... 10. Identifying and Characterizing Domains of Transcription Regulatory Factors. 11. DNA Binding by Regulatory Transcription ... In addition to a new chapter on the in vitro analysis of chromatin templates for DNA-binding studies and transcription, this ... 1. A Primer on Transcriptional Regulation in Mammalian Cells. 2. Initial Strategic Issues. 3. Transcription Initiation Site ...

https://www.cshlpress.com/default.tpl?action=full&cart=1674643913876838291&--eqskudatarq=685&typ=ps&newtitle=Transcriptional%20Regulation%20in%20Eukaryotes%3A%20Concepts%2C%20Strategies%2C%20and%20Techniques%2C%20Second%20Edition

... protein complex assembly; epidermal growth factor receptor signaling pathway; regulation of cell shape; response to bacterium; ... positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet activation; chromatin ... cell junction assembly; adherens junction organization; response to drug; positive regulation of transcription factor import ... positive regulation of actin filament bundle assembly; cellular response to hepatocyte growth factor stimulus; negative ...

https://discover.nci.nih.gov/cellminerdata/html/PROTEIN_RPPA_LIST.html

25 Myotonic Dystrophy Type 1: Focus on the RNA Pathology and Therapy Nikolaos P. Mastroyiannopoulos, Andrie Koutsoulidou and ... evidence showed that the expanded CTG repeats interfere with the nucleosome assembly and therefore on the total chromatin ... 2.4.1.7 Myocyte enhancer factor 2 (Mef2). MBNL3 regulates the splicing pattern of the muscle transcription factor myocyte ... acting factors in the alternative splicing of MYOM1 exon 17a (Koebis et al., 2011). Expression. of expanded CUG repeat impeded ...

https://vdocuments.net/myotonic-dystrophy-type-1-focus-on-the-rna-pathology-and-therapy.html

CTCF protein appears as a central factor of these two organization levels having either a strong insulating role at TAD borders ... or a weaker architectural role in chromatin loop formation. TAD borders directly impact on chromatin dynamics by restricting ... We discuss how sub-TAD chromatin dynamics, constrained into a recently described statistical helix conformation, can produce ... organization of the eukaryote genomes and discusses the relationship to chromatin loop formation. ...

https://www.mdpi.com/2073-4425/6/3/734/htm

... scarcity of replication factors to perform DNA synthesis34. Among them, insufficient amount of replication factors seems to be ... RNA reads were aligned to the GRCh38 primary assembly with Ensembl 10462 gene annotations using. STAR 2.7.9a63. Gene counts ... Whole-genome doubling drives oncogenic loss of chromatin segregation. 15 March 2023 ... In fact, aneuploid cells were found to display imbalances in factors critical for DNA replication (such as MCM2-7), DNA repair ...

https://www.nature.com/articles/s41467-023-37095-7?error=cookies_not_supported&code=b32dabf9-abce-4389-8f1f-7c761a62b02a

These factors include proteins involved in DNA maintenance, protein turnover, RNA metabolism, chromatin organisation and the ... Here, we describe the localisation of 21 protein factors to an intranucleolar region different to these main subcompartments, ... Project description:Arabidopsis thaliana mutants in FAS1 and FAS2 subunits of chromatin assembly factor 1 (CAF1) show ... Here, using single-molecule tracking of RNA polymerase I (Pol I) and chromatin-bound upstream binding factor (UBF), we reveal ...

https://www.omicsdi.org/dataset/biostudies/S-EPMC3232531

DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly ... Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei 2014 * Multiple knockout mouse models reveal ... Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies 2022 * Strategy-dependent effects of working- ... Archaeal chromatin slinkies are inherently dynamic complexes with deflected DNA wrapping pathways 2021 ...

https://vivo.colorado.edu/display/journal_171724

Dynamic plasticity of large -scale chromatin structure revealed by self-assembly of engineered chromosome regions. Journal of ... Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. Genes, Chromosomes and Cancer 2001, 32(4), ... Belmont AS, Hu Y, Sinclair PB, Wu W, Bian Q, Kireev I. Insights into interphase large-scale chromatin structure from analysis ... Main research interests are the genetics of human leukaemia and changes in higher order chromatin structure associated with ...

https://www.ncl.ac.uk/medical-sciences/people/profile/paulsinclair.html

TPX2, microtubule nucleation factor; Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of ... Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule ... TPX2, microtubule nucleation factor; Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of ... TPX2, microtubule nucleation factor; Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of ...

https://string-db.org/network/9606.ENSP00000160827

Kaufman, P. D., Kobayashi, R., Kessler, N., Stillman, B. (June 1995) The p150 and p60 subunits of chromatin assembly factor I: ... radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor- ... Henry, R. W., Mittal, V., Ma, B., Kobayashi, R., Hernandez, N. (September 1998) SNAP19 mediates the assembly of a functional ... Verreault, A., Kaufman, P. D., Kobayashi, R., Stillman, B. (October 1996) Nucleosome assembly by a complex of CAF-1 and ...

http://repository.cshl.edu/view/cshl_author/kobayashi=5Fryuji.html

The p150 subunit of human CAF-1 contains an N-terminal domain (p150N) that is dispensable for histone deposition but promotes the localization of specific loci (nucleolar-associated domains [NADs]) and proteins to the nucleolus during interphase. (nih.gov)
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer. (bvsalud.org)
Chromatin assembly factor 1 subunit A (CHAF1A) was highly correlated with proliferating cell nuclear antigen ( PCNA ) expression in EC. (bvsalud.org)
Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (chromatine.com)
1. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. (nih.gov)
9. The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. (nih.gov)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4 , is also a component of several other protein complexes involved in chromatin remodeling. (nih.gov)
The gene Chromatin assembly factor 1 subunit is referred to in FlyBase by the symbol Dmel\Caf1 (CG42. (yeastrc.org)
A member of the polyomavirus enhancer binding protein 2/core binding factor (PEBP2/CBF) is composed of PEBP2 alphaB1/AML1 (as the alpha subunit) and a beta subunit. (sdbonline.org)

How do components that regulate higher order chromatin structure contribute to genome regulation? (le.ac.uk)
Main research interests are the genetics of human leukaemia and changes in higher order chromatin structure associated with differentiation of embryonic stem cells. (ncl.ac.uk)

6. CAF-1-induced oligomerization of histones H3/H4 and mutually exclusive interactions with Asf1 guide H3/H4 transitions among histone chaperones and DNA. (nih.gov)
18. A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription. (nih.gov)
CIA (CCG1-interacting factor A)/ASF1, which is the most conserved histone chaperone among the eukaryotes, was genetically identified as a factor for an anti-silencing function (Asf1) by yeast genetic screening. (proteopedia.org)
Intensive studies have revealed that CIA/ASF1 mediates nucleosome assembly by forming a complex with another histone chaperone in human cells and yeast, and is involved in DNA replication, transcription, DNA repair and silencing/anti-silencing in yeast. (proteopedia.org)
Despite all these biochemical and biological functional analyses, the structure-function relationship of the nucleosome assembly/disassembly activity of CIA/ASF1 has remained elusive. (proteopedia.org)
The histone H3-H4 tetramer-disrupting activity of CIA/ASF1 and the crystal structure of the CIA/ASF1-histone-H3-H4 dimer complex should give insights into mechanisms of both nucleosome assembly/disassembly and nucleosome semi-conservative replication. (proteopedia.org)
Mello JA, Sillje HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. (proteopedia.org)
During her postdoctoral studies with Dr. James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila. (longevity.international)

Chromatin assembly factor 1 (CAF-1) deposits histones during DNA synthesis. (nih.gov)
8. The N-terminal domains of histones H3 and H4 are not necessary for chromatin assembly factor-1- mediated nucleosome assembly onto replicated DNA in vitro. (nih.gov)
12. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. (nih.gov)
Proteins involved in the assembly and disassembly of HISTONES into NUCLEOSOMES. (umassmed.edu)
1 Once the identity of each new cell type has been established by lineage-specific transcription factors, this identity is maintained through unique alterations in the way in which the DNA encoding each gene becomes packaged around certain proteins (i.e., the histones) within the chromatin structure of the nucleus (Hemberger et al. (nih.gov)

ASF1A_HUMAN ] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (proteopedia.org)
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein t. (yeastrc.org)
Dr. Tyler's earlier work revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. (longevity.international)
The center is combining bright photostable probes, super-resolution microscopy, and other physical and computational tools to investigate assembly, disassembly, and control of the DNA break-repair machine. (nih.gov)
In achieving our short-term and long-term goals, it is critical to visualize the dynamics of assembly and disassembly of single NHEJ complexes in the nuclei of living cells, which is far beyond the limits of existing technology. (nih.gov)

However, recent studies have revealed a complex involvement of epigenetic mechanisms in the regulation of gene expression, including methylation, chromatin modification and remodeling, and the diverse activities of non-coding RNAs. (nih.gov)
15. Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans. (nih.gov)
17. Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. (nih.gov)
Our research has focused on understanding how signalling pathways control gene expression by epigenetic modulation of chromatin structure. (le.ac.uk)
Epigenetic mechanisms allow specific gene expression outputs and involve DNA and histone modifications, including those associated with heterochromatin, a repressive form of chromatin. (nih.gov)
The control of viral IE expression is complex with regulatory mechanisms involving multiple transcription factors, coactivators, elongation factors, and epigenetic machinery that converge to determine IE expression (Fig. 2). (nih.gov)
the cell's identity then is maintained through epigenetic alterations in the way in which the DNA encoding each gene becomes packaged within the chromatin. (nih.gov)

The roles of gene methylation and miRNAs have been relatively well studied in melanoma, but other studies have shown that changes in chromatin status and in the differential expression of long non-coding RNAs can lead to altered regulation of key genes. (nih.gov)
The gene TBP-associated factor 1 is referred to in FlyBase by the symbol Dmel\Taf1 (CG17603, FBgn001. (yeastrc.org)
The VRK1 gene provides instructions for making a protein called VRK serine/threonine kinase 1. (medlineplus.gov)
VRK serine/threonine kinase 1 has a particularly important role in regulating a transcription factor called p53 (which is produced from the TP53 gene). (medlineplus.gov)
VRK1 gene mutations cause a small percentage of all cases of a form of the disorder designated pontocerebellar hypoplasia type 1 (PCH1). (medlineplus.gov)
The VRK1 gene mutations that cause PCH1A significantly reduce the amount of VRK serine/threonine kinase 1 produced in cells. (medlineplus.gov)
The VRK1 gene mutations associated with this disorder change single protein building blocks (amino acids) in VRK serine/threonine kinase 1. (medlineplus.gov)
In the fusion protein, the AML-1 runt homology domain, which is responsible for DNA binding and CBF beta interaction, is linked to ETO, a gene of unknown function. (sdbonline.org)
Previous work from the laboratory has revealed mechanistic and structural insights into how the interplay between cellular signalling, TF activation and coassembly on transcriptional enhancers controls gene expression (Fig. 1). (le.ac.uk)
CBP/p300 also acetylate chromatin and ultimately, in conjunction with remodellers and histone chaperones, makes chromatin permissive for gene transcription. (le.ac.uk)
How does chromatin modification direct nucleosome remodelling and gene regulation? (le.ac.uk)
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. (harvard.edu)
Strategies for studying gene regulation mechanisms have changed dramatically over the past several years in light of the emergence of complete genome sequences for many organisms as well as the development of or improvements to technologies such as chromatin immunoprecipitation, RNA interference, microarrays, and proteomics. (cshlpress.com)
In addition to a new chapter on the in vitro analysis of chromatin templates for DNA-binding studies and transcription, this second edition has been extensively rewritten and updated to discuss new advances in the field and their impact on gene regulation mechanisms. (cshlpress.com)
The second edition retains the approach of the first in covering both the conceptual and practical aspects of how to study the regulation of a newly isolated gene and the biochemistry of a new transcription factor. (cshlpress.com)
We are continuing to investigate mechanisms of heterochromatin assembly that are expected to have major implications for understanding gene regulatory processes in higher eukaryotes. (nih.gov)
Two key findings are: (1) the RNA degradation/facultative heterochromatin assembly machinery is a central regulator of TOR-mediated control of cell proliferation and (2) TORC1 dynamically controls RNA elimination machinery to modulate facultative heterochromatin and coordinate developmental gene expression during gametogenesis, an extremely important process that ensures the genomic integrity of future generations and lies at the heart of many heritable human disorders. (nih.gov)
IE gene products are important for the expression of subsequent waves of viral gene expression whose proteins mediate viral genome replication and final assembly-packaging of progeny viruses. (nih.gov)
and recruitment of factors required for efficient IE gene transcriptional elongation (Fig. 2). (nih.gov)

13. The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast. (nih.gov)
Her research focuses on the regulation of genomic processes by chromatin structure and mechanisms of replicative aging, using budding yeast as a model system for the aging of stem cells in humans. (longevity.international)

In addition, RanBP1 complex formation competes with chromatin binding to regulate the distribution of RCC1 between the chromatin-associated and soluble fractions. (nih.gov)
Thus, these mutational analyses define the regions of AML-1/ETO that regulate its function and that may be important in promoting leukemia (Lenny, 1995). (sdbonline.org)

Answers to some of these questions are expected to contribute to our understanding of chromatin regulation and dysregulation in disease. (le.ac.uk)
2010). Three enzymatic mechanisms control the assembly and regulation of chromatin structure: DNA methylation, modification of the histone proteins (i.e., posttranslational histone modification), and ATP-dependent chromatin remodeling (Barrero et al. (nih.gov)

It is present in protein complexes involved in histone acetylation and chromatin assembly. (nih.gov)

This protein regulates several transcription factors, which are proteins that control the activity of genes by attaching (binding) to specific regions of DNA. (medlineplus.gov)
An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (harvard.edu)

Kaufman P. Histone chaperones and chromatin assembly. (umassmed.edu)

Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (chromatine.com)
Each of the two human genes encoding the alpha and beta subunits of a heterodimeric transcription factor, PEBP2, has been found at the breakpoints of two characteristic chromosome translocations associated with acute myeloid leukemia, suggesting that they are candidate proto-oncogenes. (sdbonline.org)
Arabidopsis thaliana mutants in FAS1 and FAS2 subunits of chromatin assembly factor 1 (CAF1) show progressive loss of 45S rDNA copies and telomeres. (omicsdi.org)

3. DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication. (nih.gov)
Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration. (nih.gov)
We found that RCC1 not associated with chromosomes during mitosis is sequestered and inhibited in RCC1/Ran/RanBP1 heterotrimeric complexes and that the sequestration is crucial for normal mitotic spindle assembly. (nih.gov)
It is now clear that while mammalian genomes encode genetic information in their linear sequence, the appropriate cell type specific expression of their genes depends on higher order nuclear organization, from the folding of chromosomes into three-dimensional structures, to chromatin loops that connect genes and transcriptional regulatory complexes, to larger chromosomal domains and nuclear compartments. (nih.gov)
Higher-order transcription factor complexes such as the enhanceosome frequently recruit the co-activators CBP/p300. (le.ac.uk)
How do these signalling pathways lead to assembly of higher-order transcriptional regulatory complexes? (le.ac.uk)
How does assembly of such regulatory complexes ultimately lead to chromatin acetylation, a modification found on active chromatin? (le.ac.uk)

Defining chromatin interactions and the ways in which nuclear architecture constrains/enables interactions, and describing the relationships of genomic regions to transcription, RNA processing and chromatin regulatory machineries, is likely to reveal how individual cells access, read and interpret genetic information. (nih.gov)
Rando OJ, Robert F, Winston F. Control of chromatin structure by spt6: different consequences in coding and regulatory regions. (umassmed.edu)

1. Differential clearance mechanisms, neutrophil extracellular trap degradation and phagocytosis, are operative in systemic lupus erythematosus patients with distinct autoantibody specificities. (nih.gov)
Our work also led to the discovery of RNA-based mechanisms of heterochromatin assembly, including RNAi that utilizes small interfering RNAs (siRNAs) to target heterochromatin. (nih.gov)
RNA-based mechanisms of heterochromatin assembly are conserved in higher eukaryotes and have broad implications for human biology and disease. (nih.gov)
Our lab has discovered two distinct RNA-based mechanisms that direct the assembly of heterochromatin. (nih.gov)

Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. (proteopedia.org)
We have also uncovered an RNAi-independent mechanism in which a nuclear RNA processing complex (named MTREC) cooperates with RNA polymerase II termination factors to direct the assembly of facultative heterochromatin domains under specific growth conditions. (nih.gov)

We are using CRISPR/Cas9 to construct cell lines in which sequences encoding AIDs are inserted into both alleles of targeted genes of human tissue-culture cells that stably express the Transport Inhibitor Response 1 (TIR1) protein. (nih.gov)
Genes & Development, 31 (1). (unibas.ch)
Our work has led to the finding that heterochromatin assembly factors are part of a rheostat-like buffering mechanism that limits the uncontrolled expression of a wide variety of genes in response to environmental change. (nih.gov)
This prevents both the subsequent translocation of NICD to the nucleus to form a transcription factor complex and the expression of Notch-regulated genes. (nih.gov)

Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. (proteopedia.org)

Required for normal assembly of microtubules during apoptosis. (string-db.org)

Chromatin is the complex of DNA and protein that packages DNA into chromosomes. (medlineplus.gov)

RanBP1 is a highly conserved Ran-GTP-binding protein, which acts as co-activator of RanGAP1 (Ran GTPase-Activating Protein 1) and can form a heterotrimeric complex with Ran and RCC1 in vitro . (nih.gov)

In cells, the conversion of Ran-GDP to Ran-GTP is catalyzed by a Ran-specific guanine exchange factor called RCC1 (regulator of chromosome condensation 1) in vertebrates. (nih.gov)
The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. (string-db.org)

Here, using single-molecule tracking of RNA polymerase I (Pol I) and chromatin-bound upstream binding factor (UBF), we reveal suppression of transcription with phase separation. (omicsdi.org)

The identification of such selection entails the detection of genomic variants that show unexpectedly high population differentiation or deviation from the prevalent haplotype structure [1] - [6] . (plos.org)

Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis. (nih.gov)
During mitosis, after nuclear envelope breakdown, Ran-GTP is concentrated in the region close to mitotic chromatin, while Ran-GDP is the major form distal to chromatin. (nih.gov)
The capacity of RCC1 to bind to chromatin establishes the asymmetrical distribution of Ran-GTP in interphase as well as the chromatin-centered Ran-GTP gradient in mitosis. (nih.gov)

11. Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus. (nih.gov)
Ran is a Ras-family GTPase that plays critical roles in many cellular processes, including nucleo-cytoplasmic transport, nuclear envelope assembly, and mitotic spindle assembly. (nih.gov)
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling en. (yeastrc.org)
This protein is involved in the assembly of the nuclear envelope, which is a structure that surrounds the nucleus and acts as a barrier between the nucleus and the rest of the cell. (medlineplus.gov)
Both the assembly of the nuclear envelope and the proper organization of chromatin are necessary for normal cell division. (medlineplus.gov)
the role of specialized proteins and RNAs in the assembly, organization, and function of nuclear bodies, nuclear structures, and specialized subnuclear domains. (nih.gov)

Shortly after that, the CIA-histone-H3-H4 complex was isolated from Drosophila as a histone chaperone CAF-1 stimulator. (proteopedia.org)

14. AtMCM10 promotes DNA replication-coupled nucleosome assembly in Arabidopsis. (nih.gov)

7. Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1. (nih.gov)
16. The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. (nih.gov)

The Ran-GTP gradient guides mitotic spindle assembly by releasing spindle assembly factors (SAFs) from karyopherins based on local Ran-GTP concentrations. (nih.gov)
Spindle assembly factor required for normal assembly of mitotic spindles. (string-db.org)
Required for central/midzone spindle assembly and cleavage furrow formation. (string-db.org)

Human CIA-I/II (ASF1a/b) was identified as a histone chaperone that interacts with the bromodomain-an acetylated-histone-recognizing domain-of CCG1, in the general transcription initiation factor TFIID. (proteopedia.org)
Umehara T, Horikoshi M. Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. (proteopedia.org)
The cap droplet excluded an initiation factor, ensuring robust silencing. (omicsdi.org)

therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C116377 Osimertinib A third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. (nih.gov)

It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. (nih.gov)
Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. (nih.gov)
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to. (yeastrc.org)

Nucleoprotein Intermediates in HIV-1 DNA Integration: Structure and Function of HIV-1 Intasomes. (nih.gov)

Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M. A human homologue of yeast anti-silencing factor has histone chaperone activity. (proteopedia.org)

VRK serine/threonine kinase 1 stabilizes and activates the p53 protein and controls the levels of p53 in the nucleus. (medlineplus.gov)

11. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. (nih.gov)

Stark et al Sci Adv. 2018 Aug 1;4(8):eaat5107. (addgene.org)

These factors include proteins involved in DNA maintenance, protein turnover, RNA metabolism, chromatin organisation and the post-translational modifiers SUMO1 and SUMO2/3. (omicsdi.org)

4. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks. (nih.gov)
Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication. (nih.gov)

C-terminal deletion mutants of AML-1/ETO indicate that ETO sequences are essential for interference with AML-1B-mediated transcriptional activation, and that residue 540 defines the C-terminal boundary of a potential repression domain. (sdbonline.org)

For example, ethanol exposure disrupts cellular migration, changes cell-cell interactions, and alters growth factor signaling pathways. (nih.gov)

Over more than two decades, our lab has been delineating highly conserved heterochromatin assembly pathways. (nih.gov)

VRK serine/threonine kinase 1 is also thought to play a role in the organization of chromatin. (medlineplus.gov)

Focus on the RNA Pathology and Therapy Nikolaos P. Mastroyiannopoulos, Andrie Koutsoulidou and Leonidas A. Phylactou * Department of Molecular Genetics, Function & Therapy, The Cyprus Institute of Neurology & Genetics, Cyprus 1. (vdocuments.net)

VRK serine/threonine kinase 1 plays a critical role in directing cell growth and division. (medlineplus.gov)
Studies suggest that VRK serine/threonine kinase 1 has several additional functions. (medlineplus.gov)
Researchers speculate that VRK serine/threonine kinase 1 may be involved in the development and maintenance of the nervous system, but its role is not well understood. (medlineplus.gov)
It is also unknown why the effects of these mutations appear to be limited to the nervous system, as VRK serine/threonine kinase 1 is active in many of the body's cells and tissues. (medlineplus.gov)

An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. (umassmed.edu)

A particular emphasis has been on the roles of the cellular transcriptional coactivator HCF-1 during the initiation of lytic infection and reactivation from latency. (nih.gov)

Anatomy8

Organisms6

Diseases1

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes28

Information Science3

Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. (1/113)

WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2. (2/113)

Chromatin replication: Finding the right connection. (3/113)

Chromatin assembly during DNA replication in somatic cells. (4/113)

Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. (5/113)

Duplication and maintenance of heterochromatin domains. (6/113)

A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. (7/113)

Distinct importin recognition properties of histones and chromatin assembly factors. (8/113)

No images available that match "chromatin assembly factor 1"

Chromatin Assembly Factor-1

Chromatin

Chromatin Assembly and Disassembly

Chromosomal Proteins, Non-Histone

Retinoblastoma-Binding Protein 4

Histones

Nucleosomes

Molecular Chaperones

Retinoblastoma-Binding Protein 7

DNA-Binding Proteins

DNA Replication

Saccharomyces cerevisiae Proteins

Proliferating Cell Nuclear Antigen

Heterochromatin

Saccharomyces cerevisiae

Nucleosome Assembly Protein 1

Cell Cycle Proteins

Nuclear Proteins

Histone Acetyltransferases

Protein Binding

Histone Chaperones

S Phase

HeLa Cells

Gene Silencing

Mutation

Molecular Sequence Data

Cell Nucleus

DNA Damage

Amino Acid Sequence

Fungal Proteins

Acetylation

Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome

Nucleoplasmins

Chromatin Immunoprecipitation

Transcription, Genetic

DNA, Superhelical

Micrococcal Nuclease

Ribosome Subunits, Large, Eukaryotic

DNA

Centromere

Transcription Factors

Protein Subunits

Protein Structure, Tertiary

Gene Expression Regulation, Fungal

Base Sequence

Virus Assembly

Cell Extracts

Acetyltransferases

Mitosis

Binding Sites

Cell Line

Repressor Proteins

Promoter Regions, Genetic

Drosophila Proteins

Two-Hybrid System Techniques

Xenopus laevis

Drosophila

Adenosine Triphosphatases

Models, Biological

Sequence Homology, Amino Acid

Electron Transport Complex I

Xenopus

Lysine

DNA Repair

Macromolecular Substances

Yeasts

Cell Cycle

Models, Molecular

Histone Deacetylases

Mitochondrial Diseases

Epigenesis, Genetic

Gene Deletion

Plasmids

Deoxyribonuclease I

Recombinant Proteins

Electron Transport Complex IV

Methanococcales

Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. (1/113)

WD repeats of the p48 subunit of chicken chromatin assembly factor-1 required for in vitro interaction with chicken histone deacetylase-2. (2/113)

Chromatin replication: Finding the right connection. (3/113)