Scandium
Chemistry, Organic
Stereoisomerism
Cyclization
Catalysis
Lewis Acids
Central African Republic
Madagascar
One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)
Palladium
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Cromakalim
S-Nitrosothiols
Nitrosation
Foramen Ovale, Patent
Image Processing, Computer-Assisted
Search Engine
DNA Transposable Elements
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Image Interpretation, Computer-Assisted
Monocrotaline
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Hypertension, Pulmonary
Pulmonary Artery
Hypertrophy, Right Ventricular
KATP Channels
Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.
Potassium Channels, Inwardly Rectifying
Naphthalenes
Anemarrhena
Equol
Indenes
Modulation of chloride, potassium and bicarbonate transport by muscarinic receptors in a human adenocarcinoma cell line. (1/1004)
1. Short-circuit current (I(SC)) responses to carbachol (CCh) were investigated in Colony 1 epithelia, a subpopulation of the HCA-7 adenocarcinoma cell line. In Krebs-Henseleit (KH) buffer, CCh responses consisted of three I(SC) components: an unusual rapid decrease (the 10 s spike) followed by an upward spike at 30 s and a slower transient increase (the 2 min peak). This response was not potentiated by forskolin; rather, CCh inhibited cyclic AMP-stimulated I(SC). 2. In HCO3- free buffer, the decrease in forskolin-elevated I(SC) after CCh was reduced, although the interactions between CCh and forskolin remained at best additive rather than synergistic. When Cl- anions were replaced by gluconate, both Ca2+- and cyclic AMP-mediated electrogenic responses were significantly inhibited. 3. Basolateral Ba2+ (1-10 mM) and 293B (10 microM) selectively inhibited forskolin stimulation of I(SC), without altering the effects of CCh. Under Ba2+- or 293B-treated conditions, CCh responses were potentiated by pretreatment with forskolin. 4. Basolateral charybdotoxin (50 nM) significantly increased the size of the 10 s spike of CCh responses in both KH and HCO3- free medium, without affecting the 2 min peak. The enhanced 10 s spike was inhibited by prior addition of 5 mM apical Ba2+. Charybdotoxin did not affect forskolin responses. 5. In epithelial layers prestimulated with forskolin, the muscarinic antagonists atropine and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP, both at 100 nM) abolished subsequent 10 microM CCh responses. Following addition of p-fluoro hexahydro-sila-difenidol (pF-HHSiD, 10 microM) or pirenzepine (1 microM), qualitative changes in the CCh response time-profile also indicated a rightward shift of the agonist concentration-response curve; however, 1 microM gallamine had no effect. These results suggest that a single M3-like receptor subtype mediates the secretory response to CCh. 6. It is concluded that CCh and forskolin activate discrete populations of basolateral K+ channels gated by either Ca2+ or cyclic AMP, but that the Cl- permeability of the apical membrane may limit their combined effects on electrogenic Cl- secretion. In addition, CCh activates a Ba2+-sensitive apical K+ conductance leading to electrogenic K+ transport. Both agents may also modulate HCO3- secretion through a mechanism at least partially dependent on carbonic anhydrase. (+info)Acute troglitazone action in isolated perfused rat liver. (2/1004)
1. The thiazolidinedione compound, troglitazone, enhances insulin action and reduces plasma glucose concentrations when administered chronically to type 2 diabetic patients. 2. To analyse to what extent thiazolidinediones interfere with liver function, we examined the acute actions of troglitazone (0.61 and 3.15 microM) on hepatic glucose and lactate fluxes, bile secretion, and portal pressure under basal, insulin- and/or glucagon-stimulated conditions in isolated perfused rat livers. 3. During BSA-free perfusion, high dose troglitazone increased basal (P < 0.01), but inhibited glucagon-stimulated incremental glucose production by approximately 75% (10.0 +/- 2.5 vs control: 40.0 +/- 7.2 micromol g liver(-1), P < 0.01). In parallel, incremental lactate release rose approximately 6 fold (13.1 +/- 5.9 vs control: 2.2 +/- 0.8 mmol g liver(-1), P < 0.05), while bile secretion declined by approximately 67% [0.23 +/- 0.02 vs control: 0.70 +/- 0.05 mg g liver(-1) min(-1)), P < 0.001]. Low dose troglitazone infusion did not enhance the inhibitory effect of insulin on glucagon-stimulated glucose production, but rapidly increased lactate release (P < 0.0005) and portal venous pressure (+0.17 +/- 0.07 vs +0.54 +/- 0.07 cm buffer height, P < 0.0001). 4. These results indicate that troglitazone exerts both insulin-like and non-insulin-like hepatic effects, which are blunted by addition of albumin, possibly due to troglitazone binding. (+info)Effects of gamma-tocotrienol on ApoB synthesis, degradation, and secretion in HepG2 cells. (3/1004)
gamma-Tocotrienol (gamma-T3), a naturally occurring analog of tocopherol (vitamin E), has been shown to have a hypocholesterolemic effect in animals and humans. Unlike tocopherol, it has also been shown to reduce plasma apoB levels in hypercholesterolemic subjects. The aim of this study was to define the mechanism of action of gamma-T3 on hepatic modulation of apoB production using cultured HepG2 cells as the model system. HepG2 cells preincubated with gamma-T3 were initially shown to inhibit the rate of incorporation of [14C]acetate into cholesterol in a concentration- and time-dependent manner, with a maximum 86+/-3% inhibition at 50 micromol/L observed within 6 hours. gamma-T3, on the other hand, had no significant effect on the uptake of [14C]glycerol into pools of cellular triacylglycerol and phospholipid relative to untreated control. The rate of apoB synthesis and secretion was then studied by an [35S]methionine pulse-labeling experiment and quantified by immunoprecipitating apoB on chasing up to 3 hours. An average reduction of 24+/-3% in labeled apoB in the media was apparent with gamma-T3 despite a 60+/-2% increase in apoB synthesis. Fractionation of secreted apoB revealed a relatively denser lipoprotein particle, suggesting a less stable particle. Using a digitonin-permeabilized HepG2 cell system, the effects of gamma-T3 on apoB translocation and degradation in the endoplasmic reticulum were further investigated. The generation of a specific N-terminal 70-kDa proteolytic fragment proved to be a sensitive measure of the rate of apoB translocation and degradation. The abundance of this fragment increased significantly in gamma-T3-treated cells relative to untreated control cells (50+/-21%) after 2 hours of chase. In addition, the presence of gamma-T3 resulted in an average decrease of 64+/-8% in intact apoB. Taken together, the data suggest that gamma-T3 stimulates apoB degradation possibly as the result of decreased apoB translocation into the endoplasmic reticulum lumen. It is speculated that the lack of cholesterol availability reduces the number of secreted apoB-containing lipoprotein particles by limiting translocation of apoB into the endoplasmic reticulum lumen. (+info)Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts. (4/1004)
Troglitazone is a thiazolidinedione used for the treatment of NIDDM and potentially for other insulin-resistant disease states. Troglitazone has recently been shown to increase cardiac output and stroke volume in human subjects. These actions are thought to be mediated by the reduction of peripheral resistance, but a potential direct effect on cardiac function has not been studied. Therefore, we investigated the direct cardiac hemodynamic effects of troglitazone in isolated perfused rat hearts. Five groups of hearts were studied. Hearts were tested under isovolumetric contraction with a constant coronary flow, and troglitazone (0.2, 0.5, and 1.0 micromol) was administered by bolus injection. Peak isovolumetric left ventricular pressure (LVPmax), peak rate of rise of LVP (dP/dt(max)), and peak rate of fall of LVP (dP/dt(min)) were significantly increased 1 min after troglitazone administration in a dose-dependent manner, while the heart rate (HR) and coronary perfusion pressure (CPP) were significantly decreased (P < 0.05). HR was then fixed by pacing and/or CPP was fixed with nitroprusside to eliminate any effect of the two variables on the action of troglitazone. With constant HR and/or constant CPP, the effect of troglitazone on LVPmax, dP/dt(max), and dP/dt(min) was still unchanged. In addition, the positive inotropic, positive lusitropic, and negative chronotropic actions of troglitazone were not influenced even when hearts were pretreated with prazosin, propranolol, or nifedipine. In conclusion, troglitazone has direct positive inotropic, positive lusitropic, negative chronotropic, and coronary artery dilating effects. The inotropic and chronotropic actions of troglitazone are not mediated via adrenergic receptors or calcium channels. These findings have important clinical implications for diabetic patients with congestive heart failure. (+info)Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. (5/1004)
We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also independently of such death receptors. Here we investigated mitochondria-dependent mechanisms of NO-induced apoptosis in Jurkat leukemic cells. NO donor glycerol trinitrate (at the concentration, which induces apoptotic cell death) caused (1) a significant decrease in the concentration of cardiolipin, a major mitochondrial lipid; (2) a downregulation in respiratory chain complex activities; (3) a release of the mitochondrial protein cytochrome c into the cytosol; and (4) an activation of caspase-9 and caspase-3. These changes were accompanied by an increase in the number of cells with low mitochondrial transmembrane potential and with a high level of reactive oxygen species production. Higher resistance of the CD95-resistant Jurkat subclone (APO-R) cells to NO-mediated apoptosis correlated with the absence of cytochrome c release and with less alterations in other mitochondrial parameters. An inhibitor of lipid peroxidation, trolox, significantly suppressed NO-mediated apoptosis in APO-S Jurkat cells, whereas bongkrekic acid (BA), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. Transfection of Jurkat cells with bcl-2 led to a complete block of apoptosis due to the prevention of changes in mitochondrial functions. We suggest that the mitochondrial damage (in particular, cardiolipin degradation and cytochrome c release) induced by NO in human leukemia cells plays a crucial role in the subsequent activation of caspase and apoptosis. (+info)Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. (6/1004)
Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro. Because the differentiation status of liposarcoma is predictive of clinical outcomes, modulation of the differentiation status of a tumor may favorably impact clinical behavior. We have conducted a clinical trial for treatment of patients with advanced liposarcoma by using the peroxisome proliferator-activated receptor-gamma ligand troglitazone, in which extensive correlative laboratory studies of tumor differentiation were performed. We report here the results of three patients with intermediate to high-grade liposarcomas in whom troglitazone administration induced histologic and biochemical differentiation in vivo. Biopsies of tumors from each of these patients while on troglitazone demonstrated histologic evidence of extensive lipid accumulation by tumor cells and substantial increases in NMR-detectable tumor triglycerides compared with pretreatment biopsies. In addition, expression of several mRNA transcripts characteristic of differentiation in the adipocyte lineage was induced. There was also a marked reduction in immunohistochemical expression of Ki-67, a marker of cell proliferation. Together, these data indicate that terminal adipocytic differentiation was induced in these malignant tumors by troglitazone. These results indicate that lineage-appropriate differentiation can be induced pharmacologically in a human solid tumor. (+info)Inhibition of LDL oxidation in vitro but not ex vivo by troglitazone. (7/1004)
Diabetic subjects are at increased risk for developing coronary artery disease, in part because of increased oxidation of LDL, which promotes atherogenesis. Troglitazone, a new antidiabetic drug of the thiazolidinedione class, acts as an insulin sensitizer and improves hyperglycemia. Structurally, it contains a tocopherol moiety similar to vitamin E and has been shown to have antioxidant properties in vitro. Therefore, we evaluated whether troglitazone inhibited LDL oxidation both in vitro and in type 2 diabetic subjects ex vivo. Troglitazone inhibited oxidation of LDL induced by Cu2+ or 2'2'-azobis-2-amidinopropane hydrochloride (AAPH) with 50% inhibition at 1 micromol/l and 100% inhibition at 5-10 micromol/l troglitazone. The inhibition of LDL oxidation by troglitazone also was time dependent. In addition, troglitazone inhibited oxidation of 125I-labeled LDL and its subsequent uptake and degradation by macrophages. To determine whether troglitazone was incorporated into LDL particles or acted in the aqueous milieu, troglitazone was incubated overnight at 37 degrees C with LDL or plasma before LDL re-isolation. After re-isolation, LDL that was incubated with troglitazone was no longer protected from oxidation, compared with probucol-treated LDL, which remained protected. Further, [14C]troglitazone did not get incorporated into LDL. This suggests that troglitazone exerts its antioxidant effect in the aqueous milieu of LDL. Consistent with this was the observation that the lag phases of copper-induced conjugated diene formation, a measure of the susceptibility in vivo, was similar for subjects taking troglitazone (76 +/- 5 min, n = 9) to subjects not taking the drug (77 +/- 3 min, n = 11; NS). Thus, troglitazone may be of value as an aqueous-phase antioxidant in addition to its effect on glucose homeostasis. (+info)Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. (8/1004)
We have tested our prediction that AM630 is a CB2 cannabinoid receptor ligand and also investigated whether L759633 and L759656, are CB2 receptor agonists. Binding assays with membranes from CHO cells stably transfected with human CB1 or CB2 receptors using [3H]-CP55940, confirmed the CB2-selectivity of L759633 and L759656 (CB2/CB1 affinity ratios = 163 and 414 respectively) and showed AM630 to have a Ki at CB2 receptors of 31.2 nM and a CB2/CB1 affinity ratio of 165. In CB2-transfected cells, L759633 and L759656 were potent inhibitors of forskolin-stimulated cyclic AMP production, with EC50 values of 8.1 and 3.1 nM respectively and CB1/CB2 EC50 ratios of > 1000 and > 3000 respectively. AM630 inhibited [35S]-GTPgammaS binding to CB2 receptor membranes (EC50 = 76.6 nM), enhanced forskolin-stimulated cyclic AMP production in CB2-transfected cells (5.2 fold by 1 microM), and antagonized the inhibition of forskolin-stimulated cyclic AMP production in this cell line induced by CP55940. In CB1-transfected cells, forskolin-stimulated cyclic AMP production was significantly inhibited by AM630 (22.6% at 1 microM and 45.9% at 10 microM) and by L759633 at 10 microM (48%) but not 1 microM. L759656 (10 microM) was not inhibitory. AM630 also produced a slight decrease in the mean inhibitory effect of CP55940 on cyclic AMP production which was not statistically significant. We conclude that AM630 is a CB2-selective ligand that behaves as an inverse agonist at CB2 receptors and as a weak partial agonist at CB1 receptors. L759633 and L759656 are both potent CB2-selective agonists. (+info)
Update in Endocrinology | Annals of Internal Medicine | American College of Physicians
Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol
Measurement of the Vitamin E Metabolites, Carboxyethyl Hydroxychromans (CEHCs), in Biological Samples - Current Protocols
ethyl 4-((N-(2,2,4,4-tetramethylchroman-6-yl)thiocarbamoyl)amino)benzoate
Summary Report | CureHunter
INVOLVEMENT OF ORGANIC ANION TRANSPORTING POLYPEPTIDES IN THE TRANSPORT OF TROGLITAZONE SULFATE: IMPLICATIONS FOR UNDERSTANDING...
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Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. - PubMed - NCBI
Piperidylmethyl-substituted chroman derivatives as active ingredients for the treatment of disorders of the central nervous...
TIDNINGSARKIVET.SE: EN FRÅGA OM TRO
Is it OK tro open thsi file?
Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol - Article abstract #878274 |...
Gamma-tocotrienol stimulates the proliferation, differentiation, and mineralization in osteoblastic MC3T3-E1 cells
Oxidative Stress Status Evaluation at Chemical and Biochemical Levels using Novel/Improved and Contemporary Methods - Eprints...
The toxicity of troglitazone, roziglitazone and vitamin e in human hep g2 hepatoma cells - Strathprints
Troglitazone - Wikipedia
Tocotrienol Complex - ExcelVite
Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production | eLife
Thiazolidinedione
Cardiovascular, Ocular and Bone Adverse Reactions Associated with Thiazolidinediones | SpringerLink
ebelactone A | Semantic Scholar
TRO - Trophinin - Homo sapiens (Human) - TRO gene & protein
Search Articles | University of Toronto Libraries
Linux Test Project / Mailing Lists
Re: ontlWXvAKuc
The Fifth Element #86 | Stereophile.com
Plasma vitamin E metabolite concentrations in pregnant women and umbil by Svetlana Didenco
Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death | BMC Cancer | Full...
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
IJMS | Free Full-Text | The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial...
Global Market Report of 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene (CAS 6683-48-3)
Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats<...
The PPAR-γ Agonist Troglitazone Protects RPE Cells from Oxidized LDL Induced NLRP3-inflammasome-Mediated Cell Death | IOVS |...
HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers |...
Antioxidants can increase… - Göteborgs universitet
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Biblio | College of Public Health and Human Sciences | Oregon State University
Quality Assurance and Quality Control for African Natural Plant Products from the Ground Up
Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of...
WikiGenes - Targret - 4-[1-(3,5,5,8,8-pentamethyl-6,7...
6.1.2.4 Glitazones (thiazolidinediones)
Zazie dans le métro: Girl Trouble | The Current | The Criterion Collection
ratio-Pioglitazone - Uses, Side Effects, Interactions - Canoe.com
45 Comments
Ligand for peroxisome proliferator-activated receptor γ (Troglitazone) has potent antitumor effect against human prostate...
Combined Treatment with Troglitazone and Lovastatin Inhibited Epidermal Growth Factor-Induced Migration through the...
Repositorio da Producao Cientifica e Intelectual da Unicamp: Optimization of the Enzymatic Hydrolysis of Blue Shark Skin
The protective effect of Opuntia dillenii Haw fruit against low-density lipoprotein peroxidation and its active compounds<...
Bioavailability of tocotrienols: evidence in human studies | Nutrition & Metabolism | Full Text
Prostate Health - TOCOTRIENOL Tocotrienol.org
Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis. | Sigma...
Efficacy and Safety Study of MP-513 in Combination With Thiazolidinedione in Patients With Type 2 Diabetes - Full Text View -...
Patent US5856490 - Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and ... - Google Patents
Development of antidiabetic agents - Part 1, by Professor Birgitte Holst - Development of antidiabetic agents | Coursera
Tocotrienols | GreenMedInfo | Substance | Natural Medicine
Tocotrienols | Free People
Delta-Fraction Tocotrienols 125 mg 30 Softgels , made by nutricology
C o m p u te r M o d e lin g o f M o le c u la r E le c tro n ic S tru c tu re - PDF
Thiazolidinediones: A 2010 Perspective
Pozitivna psihologija časa - VideoLectures.NET
Tro, den yttre världen och filosoferna
KEGG SSDB Best Search Result: tro:trd 0132
When Should You Not Take TZDs: A Quick Overview | Sepalika
Neena GILL | História pôsobenia v Parlamente | Poslanci EP | Európsky parlament
Algorithm - Wicipedia
JOSIE
- Andy & Lucy
Muhammed Fuzuli (1498-1556) - Chapters LXVIII - LXXXVII
Chromane
Such compounds are sometimes described as chromans. Chromene (benzopyran) Media related to benzodihydropyrans at Wikimedia ...
Ormeloxifene
Structure-activity relation of 3,4-diphenylchromenes and -chromans". Journal of Medicinal Chemistry. 19 (2): 276-9. doi:10.1021 ...
Hericenone
"Chromans, hericenones F, G and H from the mushroom Hericium erinaceum". Phytochemistry. 32 (1): 175-178. 1992-12-23. doi: ... "Chromans, hericenones F, G and H from the mushroom Hericium erinaceum". Phytochemistry. 32: 175-178. doi:10.1016/0031-9422(92) ...
Aleksandr Dianin
... rapid cyclisation reactions producing flavans and chromans occur. This is the source of Dianin's compound in the mixture, and ...
List of MeSH codes (D03)
... chromans MeSH D03.438.150.240.190 - catechin MeSH D03.438.150.240.225 - centchroman MeSH D03.438.150.266 - chromones MeSH ... chromans MeSH D03.830.219.240.190 - catechin MeSH D03.830.219.240.225 - centchroman MeSH D03.830.219.266 - chromones MeSH ...
Phytane
... chromans, an aromatic compound believed to be markers of salinity. Therefore, this decrease in Pr/Ph should indicate an ...
Synthesis of chromans viaPd-catalyzed alkene carboetherification reactions - Chemical Communications (RSC Publishing)
2-disubstituted chromans viaPd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl) ... Synthesis of chromans viaPd-catalyzed alkene. carboetherification reactions A. F. Ward, Y. Xu and J. P. Wolfe, Chem. Commun., ... A new method for the construction of 2-substituted and 2,2-disubstituted chromans viaPd-catalyzed carboetherification reactions ...
RCSB PDB - 4RRO: 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1...
Asymmetric synthesis of chromans via the Friedel-Crafts alkylation-hemiketalization catalysed by an N,N′-dioxide scandium(iii)...
3-disubstituted chromans in the presence of a chiral N,N′-dioxide/Sc(OTf)3 complex. High enantioselectivities (up to 95% ee), ... Asymmetric synthesis of chromans via the Friedel-Crafts alkylation-hemiketalization catalysed by an N,N′-dioxide scandium(III) ... Asymmetric synthesis of chromans via the Friedel-Crafts alkylation-hemiketalization catalysed by an N,N′-dioxide scandium(III) ... 3-disubstituted chromans in the presence of a chiral N,N′-dioxide/Sc(OTf)3 complex. High enantioselectivities (up to 95% ee), ...
EN (en)
... catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts allylation/ ... Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols. ... A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts ...
Patent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patents
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial
Penetration and distribution of alpha-tocopherol, alpha- or gamma-tocotrienols applied individually onto murine skin
To evaluate skin penetration of various vitamin E homologs, a 5% solution of either alpha-tocopherol, alpha-tocotrienol, or gamma-tocotrienol in polyethylene glycol was topically applied to SKH-1 hairless mice. After 0.5, 1, 2, or 4 h (n = four per time point and four per vitamin E homolog), the ski …
Romans 9 Commentary - Greek Testament Critical Exegetical Commentary
See ch. Romans 4:1-12. As to the construction here, it is best to regard ἀλλὰ καὶ … ἔχουσα … ἡμῶν as a sentence begun but ... The places are, ch. Romans 1:25, ἐλάτρευσαν τῇ κτίσει παρὰ τὸν κτίσαντα, ὅς ἐστιν εὐλογητὸς εἰς τοὺς αἰῶνας. ἀμήν,-and 2 ... See ch. Romans 10:3; Romans 10:5, and note; and compare Johns coming ἐν ὁδῷ δικαιοσύνης, Matthew 21:32), arrived not at [ ... and ch. Romans 13:13, where the meaning is not exactly the same though cognate) by one man (in the former case, the children ...
The Chemistry of Heterocyclic Compounds, Condensed Imidazoles, 5-5 Ring Systems | Ebook | Ellibs Ebookstore
The Chemistry of Heterocyclic Compounds, Benzimdazoles and Cogeneric Tricyclic Compounds | Ebook | Ellibs Ebookstore
Reactions and Syntheses: In the Organic Chemistry Laboratory, 2nd, Completely Revised and Updated Edition | Methods - Synthesis...
Dr. Leroy Shervington | Staff Profile | University of Central Lancashire
TNO Repository search for: subject:'Retinoic acid'
Biblio | Page 4 | Linus Pauling Institute | Oregon State University
Patent US5840475 - Photothermographic element for providing a viewable retained image - Google Patents
Thieme E-Books & E-Journals - Synfacts / Aktuelle Ausgabe
Chromane - Wikipedia
JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats....
Advanced Search Results - Public Health Image Library(PHIL)
PhD defense | UCI Department of Chemistry
US4289883A - Carbostyril compounds
- Google Patents
Romans 11 Cambridge Bible for Schools and Colleges
thou standest] See on ch. Romans 5:2.. Romans 11:21. For if God spared not the natural branches, take heed lest he also spare ... Ch. Romans 11:1-10. Meanwhile the rejection of Israel never was, nor is, total: a remnant believes, and so abides in covenant. ... On "reconciliation," see on ch. Romans 5:1; Romans 5:11.. life from the dead] i.e. a vast and intense revival of true religion ... goodness] See on ch. Romans 2:4.. severity] In the special sense of summary sternness. The word is akin to that rendered " ...
Ormeloxifene - Wikipedia
Antioxidants | Free Full-Text | Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative...
IT1145952B - Calandra with fixed lower rollers and upper roller oscillating - Google Patents
Scearce-Levie K[au] - PubMed - NCBI
Patent US5856490 - Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and ... - Google Patents
Molecules | Free Full-Text | A Study of Palladium Catalyzed Intra/Intermolecular Cascade Cross Coupling/Cyclizations Involving...
Patent US4723028 - Stilbene derivatives - Google Patents
Phenols3
- A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl /alkenyl halides and 2-(but-3-en-1-yl)phenols is described. (rsc.org)
- An enantioselective tandem Friedel-Crafts alkylation-hemiketalization between electron-rich phenols and α,β-unsaturated ketoesters gave a direct approach to chiral 2,3-disubstituted chromans in the presence of a chiral N , N ′-dioxide/Sc(OTf) 3 complex. (rsc.org)
- A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts allylation/intramolecular hydroalkoxylation sequence. (pasteur.fr)
Amyloid1
- Discovery of 7-tetrahydropyran-2-yl chromans: ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid ß-protein (Aß) in the central nervous system. (healthsciencessc.org)
Compounds2
- Such compounds are sometimes described as chromans. (wikipedia.org)
- The compounds [3-(2-Bromocyclohex-2-enyloxy)prop-1-ynyl]- tert -butyl-dimethylsilane 3 , [4-(2-bromocyclohex-2-en-1-yloxy)but-2-yn-1-yloxy]tert-butyldimethylsilane 5 and dimethyl 2-(2-bromocyclohex-2-enyl)-2-(3-( tert -butyldimethylsilanyl)prop-2-ynyl)malonate 9 were prepared and subjected to palladium-catalyzed intra-intermolecular cascade cross couplings incorporating bicyclopropylidene 10 under two types of conditions. (mdpi.com)
Chemistry1
- After completing his BSc(Hons) at the University College Cardiff, Leroy continued his interest in chemistry by studying for PhD in organic medicinal chemistry within the same university, synthesising numerous (2-fluoropheny1) propan-1-ols and converting them to the corresponding chromans under the influence of rhodium catalyst. (uclan.ac.uk)