Choroid Neoplasms: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).Choroid Plexus: A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.Choroid: The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.Choroid Plexus Neoplasms: Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)Papilloma, Choroid Plexus: A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Choroid Diseases: Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.Cerebral Ventricle Neoplasms: Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Skin Neoplasms: Tumors or cancer of the SKIN.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Uvea: The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)Kidney Neoplasms: Tumors or cancers of the KIDNEY.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Ependyma: A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.Eye Neoplasms: Tumors or cancer of the EYE.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Sclera: The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.DNA, Neoplasm: DNA present in neoplastic tissue.Lung Neoplasms: Tumors or cancer of the LUNG.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Ornithine-Oxo-Acid Transaminase: A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 2.6.1.13.Liver Neoplasms: Tumors or cancer of the LIVER.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Ciliary Body: A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Meninges: The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Lymphoma, T-Cell, Peripheral: A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Lymphoma, T-Cell: A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.Artificial Cells: Chemically synthesized structures which functionally resemble natural cells.Dermoid Cyst: A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)Cerebellar Ataxia: Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)Brachial Plexus: The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Ultrasonic characterisation of malignant melanoma of choroid. (1/324)
An in-vitro study of wave spectral analysis in 8 enucleated eyes was conducted in order to differentiate histological subtypes of malignant melanoma. To obtain the backscattering coefficient for the tissues, we used a broadband focussed transducer with a frequency range of 7-12 MHz and a centre frequency of 10 MHz. Experimental measurement of backscattering coefficient and attenuation coefficient at various frequencies was done by substitution techniques. The backscattering coefficient, scatterer size, and root mean square velocity fluctuation were derived by the numerical method, while the attenuation coefficient at 1 MHz was derived from attenuation coefficient at different frequencies. This study revealed that backscattering coefficient and attenuation coefficient, over a frequency range of 7-12 MHz, show an increase in the spindle cell type compared to the mixed cell type of malignant melanoma. Particularly, the scatterer size was significantly higher in the spindle cell group (p = 0.013) in contrast to the mixed cell type. Spindle cells have uniform and compact histological pattern which contributes to an increase in scatterer size and root mean square velocity fluctuation. The ultrasonically obtained parameters have been shown to have a good correlation with the histology of malignant melanoma. (+info)Radioactive phosphorus uptake testing of choroidal lesions. A report of two false-negative tests. (2/324)
Two false-negative results from 32P testing for histologically verified malignant melanomas of the choroid are reported. In the first case, a haemorrhagic choroidal detachment caused an increase in probe; additionally, the tumour was necrotic. Both factors are likely to have contributed to the false-negative result. A satisfactory explanation for the false-negative result in the second case was not determined, although it may have accurately reflected a period of minimal tumour activity, inasmuch as repeat 32P testing was strongly positive eight months later, when unequivocal evidence of tumour growth was present. An alternative explanation is that the orally administered 32P was incompletely absorbed. Since 32P testing is frequently accompanied by significant manipulation both in the manoeuvre associated with tumour localization and in that associated with the actual radioactive counting, it would seem desirable to perform indicated enucleation immediately after completion of the 32P testing. While the properly performed 32P test remains a valuable diagnostic test for helping to establish the presence or absence of malignancies of the posterior globe, it is important to guard against the tendency to underestimate careful clinical evaluation. (+info)Combination chemotherapy for choroidal melanoma: ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside. (3/324)
Treatment of choroidal melanoma by chemotherapy is usually unsuccessful, with response rates of less than 1% reported for dacarbazine (DTIC)-containing regimens which show 20% or more response rates in skin melanoma. Recently, we reported the activity of several cytotoxic agents against primary choroidal melanoma in an ATP-based tumour chemosensitivity assay (ATP-TCA). In this study, we have used the same method to examine the sensitivity of choroidal melanoma to combinations suggested by our earlier study. Tumour material from 36 enucleated eyes was tested against a battery of single agents and combinations which showed some activity in the previous study. The combination of treosulfan with gemcitabine or cytosine arabinoside showed consistent activity in 70% and 86% of cases, respectively. Paclitaxel was also active, particularly in combination with treosulfan (47%) or mitoxantrone (33%). Addition of paclitaxel to the combination of treosulfan + cytosine analogue added little increased sensitivity. For treosulfan + cytosine arabinoside, further sequence and timing experiments showed that simultaneous administration gave the greatest suppression, with minor loss of inhibition if the cytosine analogue was given 24 h after the treosulfan. Administration of cytosine analogue 24 h before treosulfan produced considerably less inhibition at any concentration. While we have so far been unable to study metastatic tumour from choroidal melanoma patients, the combination of treosulfan with gemcitabine or cytosine arabinoside shows activity ex vivo against primary tumour tissue. Clinical trials are in progress. (+info)Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance. (4/324)
We evaluated 55 samples of choroidal melanoma managed by enucleation. Knowing that the immunohistochemical expression of the retinoblastoma gene family members Rb/p105, p107, and pRb2/p130 was inversely correlated with the degree of malignancy in at least some histological types, we investigated the expression of these three proteins in choroidal melanoma. We focused on the relationship between patient survival and the immunohistochemical detection of the retinoblastoma proteins. No correlation with clinical outcome was found for Rb/p105 and p107. However, we found pRb2/p130 to be an independent prognostic factor correlating positively or directly with patient survival times and indirectly or inversely with the degree of malignancy. Demonstration of the prognostic value of the immunohistochemical expression of pRb2/p130 is of significance, even if additional studies are required to confirm these data and to compare the prognostic value of pRb2/p130 immunodetection to that of other recently proposed markers, such as p53. (+info)Alpha/beta- and gamma/delta TCR(+) lymphocyte infiltration in necrotising choroidal melanomas. (5/324)
AIM: To detect specific tumour infiltrating T cells (TIL) carrying antigen specific MHC-I restricted receptor genes on necrotising and non-necrotising malignant melanomas and to correlate the findings with clinical data. METHODS: alpha/beta- and gamma/delta- TIL were determined by immunohistochemical staining in melanomas of patients with known follow up of more than 10 years. An antigen retrieval method was used to determine variable genes delta1 and gamma1 on TCR(+) cells by an anti-TCR Vdelta1 and anti-CrgammaM1, and of Valpha and Vbeta TCR(+) by an anti-pan-TCR(+) alpha/beta antibody. RESULTS: Intratumoral TIL were present in 86 of 113 (76.1%) necrotising melanomas (NMM) v 21 of 100 (21%) in non-necrotising melanomas (MM); of these, Valpha/beta- TCR(+) cells were present in 52 of 74 (70.3%) TIL harbouring NMM v four of 21 (19%) MM; Vgamma1 in 29 of 74 (39.2%) NMM v two of 21 (10%) MM; and Vdelta1 in 39 of 74 (52.7%) NMM v three of 21 (14%) MM. Extratumoral lymphocytic infiltration was seen in 86 (76.1%) NMM including Valpha/beta TCR(+) cells in 10 (11.6%) cases, v five (5%) MM cases with no Valpha/beta TCR(+) cells detected. Vgamma1 and Vdelta1 TCR(+) cells were not found in extratumoral infiltrates. CONCLUSIONS: In NMM, the median survival was 69.3 (range 6-237) months, 19 of 74 patients (25.7%) survived 5 years, and mortality was associated with advanced stage (p<0.001), patient age (p<0.023), and extent of necrosis (p<0.048). Survival was increased with evidence of Vgamma1 and Vdelta1 TCR(+) cells (p<0.026). (+info)Microvascular density in predicting survival of patients with choroidal and ciliary body melanoma. (6/324)
PURPOSE: Although malignant uveal melanoma disseminates predominantly hematogenously because of the absence of intraocular lymphatics, consensus about prognostic impact of microvascular density (MVD) has not been reached. This study was undertaken to investigate whether MVD, microvascular patterns, or both determine prognosis of uveal melanoma. METHODS: A population-based retrospective cohort study of melanoma-specific and all-cause mortality of 167 consecutive patients who had an eye enucleated because of choroidal or ciliary body melanoma from 1972 through 1981 was conducted. MVD was determined by counting tumor vessels in a masked fashion from areas of highest vessel density after immunostaining for CD34 epitope, factor VIII-related antigen (FVIII-RAg), and alpha-smooth muscle actin (SMA). Kaplan-Meier and Cox regression analyses of survival were performed. The association between MVD and tumor size and location, cell type, and microvascular patterns was assessed. RESULTS: MVD could be determined from 134 of 167 melanomas (80%). Based on globally highest count obtained with antibodies to CD34, MVD ranged from 5 to 121 vessels/0.313 mm2 (median, 40) and its association with presence of microvascular loops and networks (P = 0.0006), epithelioid cells (P = 0.028), and largest basal tumor diameter (P = 0.0029) was statistically significant. The 10-year melanoma-specific mortality increased with MVD (0.09, 0.29, 0.59, and 0.64, according to quartiles; P < 0.0001), as did all-cause mortality (P = 0.0022). Equivalent results were obtained with immunostaining for FVIII-RAg, whereas MVD obtained with antibodies to SMA was not associated with prognosis. Cox regression showed a hazard ratio of 2.45 (95% CI, 1.43-4.18) for presence of epithelioid cells, 1.11 (95% CI, 1.03-1.20) for largest basal diameter, 1.23 (95% CI, 1.06-1.43) for square root-transformed MVD, and 1.51 (95% CI, 1.09-2.10) for presence of loops and networks, all of which independently contributed to prognosis. CONCLUSIONS: The findings support the theory that both MVD and microvascular patterns contribute independently to prognosis in uveal melanoma in addition to cell type and size of the tumor. (+info)Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up. (7/324)
AIMS: To evaluate the effect of high dose stereotactic radiotherapy on the ocular blood flow of patients with uveal melanoma. METHODS: Colour Doppler imaging (CDI) was used to measure blood flow velocity and vascular resistance in the ophthalmic, short posterior, and central retinal arteries of nine patients suffering from uveal melanoma. The measurements were taken before, 6 months, 1 year, and 2 years after stereotactic radiotherapy. Irradiation was performed with the Leksell gamma knife with the 59 (41-66.5) Gy total marginal dose divided in two equal fractions. CDI results were compared with age and sex matched healthy control eyes. RESULTS: At each time of measurement, blood flow velocity in the central retinal artery of the affected eyes was significantly reduced whereas vascular resistance was only increased at the 2 year follow up. Blood flow velocity and vascular resistance in the short posterior arteries of melanoma eyes were also only significantly altered at the 2 year follow up. Blood flow velocity and vascular resistance in the ophthalmic artery of melanoma eyes were not changed at all follow ups. CONCLUSIONS: In the melanoma eyes, blood flow velocity in the central retinal artery is reduced. High dose stereotactic radiotherapy with the Leksell gamma knife and a 59 (41-66.5) Gy total marginal dose in two fractions leads to a significant reduction of blood flow and a significant increase in resistance variables in the small ocular arteries within 2 years. (+info)Transpupillary thermotherapy as primary treatment for small choroidal melanomas. (8/324)
PURPOSE: To report short-term follow-up of eyes containing small choroidal melanomas that were treated with transpupillary thermotherapy (TTT). METHODS: Twenty eyes with suspected small choroidal melanomas were treated with TTT using infrared light delivered from the diode laser. RESULTS: The age of patients ranged from 26 to 82 years. In 14, there was documented growth of the melanoma prior to TTT. Tumor thicknesses ranged from less than 1 to 3.2 mm. Seven tumors were treated more than once. Follow-up ranged from 6 months to more than 3 years. Following treatment, tumor thicknesses decreased in all cases, usually within 2 months. Progressive atrophy of tumor mass and loss of pigmentation within the tumor continued beyond 1 year of follow-up in some eyes. Complications included field defects, vascular changes, and macular abnormalities. CONCLUSIONS: Transpupillary thermotherapy of small choroidal melanomas is usually followed by early tumor shrinkage but is complicated by dense scotomas, nerve fiber bundle defects, and occasionally macular abnormalities. Short-term follow-up suggests that TTT may arrest growth of selected small melanomas. (+info)
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![adult choroid plexus neoplasm 2005:2010[pubdate] *count=100 - BioMedLib™ search engine](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAIAAACQkWg2AAAAA3NCSVQICAjb4U/gAAABLUlEQVQokWP8//8/AymAiSTVg1SDfmgut0u8RkDG/DVbGRgYpFO6hBI7IHKx7YsYQ+q//fiZMHlzxvRtUA2X7j59v2NerJtVUmgVAwPDs++/3r/6tOP45VfvPy3Zd4Xh+29GBobvv/5+//0X5iQOttnLN6zYe6J9eikDAwPDv38xNhrVy/dOXX8wwkGL4d9/BkZGRkYGRka4H/79U1OUTfNzqqyd9+TZC4b/DFEOBl9//W1ae6wo0J7hx2+IOkYGqA4Wht9/XW3MxISFGN78fPjsJQMj47cfv1cVh735+IWZmYnh7z+G//8ZGBg+/fj98v3nH7//sjBwsjEqeTDwcNT0JVqb6DMwb/73/7+eqiwDA8Opq/cYeNj/MzDwsLPOvf5sXflSBgYGxpGYNAAO23sdtamYqgAAAABJRU5ErkJggg==)
adult choroid plexus neoplasm 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
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PapillomaCarcinomaTumorCarcinomasRetinaMelanomaIntracranial neoplasmsEpendymomaEpitheliumCiliaryDiagnosisPediatricMetastasisHyperplasia of the choroid plexusPatients with choroid plexus tumorsMeningiomaThird ventricleNeuroendocrineCPPsRare tumorsResected choroid plexus tumorsAdultChoroidalEpithelialHydrocephalusCentral nervous sTumors are rareHistologyCommon intraventricularAbstractCases of choroidIntraventricular neoplasmsLateral ventriclesMethylationIntraocular tumors
Papilloma21
- Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
- This coronal T1-weighted magnetic resonance image (MRI) following contrast administration shows a homogeneously enhancing choroid plexus papilloma within the right lateral ventricle of a 1-year-old boy. (medscape.com)
- Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea Young, Paul A. (2007). (wikipedia.org)
- There are three histopathological classifications of choroid plexus tumors: choroid plexus papilloma (CPP), atypical choroid plexus papilloma (ACP), and choroid plexus carcinoma (CPC). (springer.com)
- Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature. (springer.com)
- Choroid plexus papilloma in a girl with hypomelanosis of Ito. (springer.com)
- Suprasellar seeding of a benign choroid plexus papilloma of the fourth ventricle with local recurrence. (springer.com)
- Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. (springer.com)
- A choroid plexus papilloma is usually treated with a total mass resection. (aao.org)
- PTPR have morphological features in common with a number of other papillary-like tumors that occur in the pineal region, including pineal parenchymal neoplasms, choroid plexus papilloma, papillary ependymoma, metastatic papillary carcinomas, papillary meningioma and germ cell tumors ( 5 , 7 ), which complicates the clinical diagnosis of PTPR. (spandidos-publications.com)
- 53 Choroid plexus papilloma (CPP) ia a non-cancerous (benign) tumor of the choroid plexus, a network of blood vessels in the brain which surrounds the ventricles and produces the fluid surrounding the brain and spinal cord (cerebrospinal fluid, or CSF). (malacards.org)
- Papilloma of Choroid Plexus, also known as choroid plexus papilloma , is related to choroid plexus cancer and atypical choroid plexus papilloma , and has symptoms including seizures , vomiting and headache . (malacards.org)
- An important gene associated with Papilloma of Choroid Plexus is TP53 (Tumor Protein P53), and among its related pathways/superpathways are MAPK signaling pathway and Cell cycle . (malacards.org)
- 75 Papilloma of choroid plexus: A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. (malacards.org)
- The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
- Glial fibrillary acidic protein (GFAP) may be positive in up to 20% of cases of choroid plexus papilloma. (statpearls.com)
- Genetic analyses have reported germline mutations in the TP53 gene in some patients with choroid plexus papilloma. (statpearls.com)
- Syndromic associations of choroid plexus papilloma include Aicardi syndrome, hypomelanosis of Ito, and 9p duplication. (statpearls.com)
- Pineal region choroid plexus papilloma treated with stereotactic radiosurgery: a case study. (naver.com)
- Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series. (naver.com)
- Choroid plexus papilloma (CPP) are the most common tumor arising in the trigone of the lateral ventricle in children. (uab.edu)
Carcinoma18
- Gross total resection improves overall survival in children with choroid plexus carcinoma. (springer.com)
- Eppinger MA, Berman CM, Halpern SL, Mazzola CA (2016) Prolonged Survival for Choroid Plexus Carcinoma with Oncocytic Changes: A Case Report. (omicsonline.org)
- Introduction: Choroid plexus carcinoma (CPC) is a rare central nervous system neoplasm derived from the choroid plexus epithelium. (omicsonline.org)
- Choroid plexus carcinoma s ( CPC ) are rare, malignant neoplasms that represent 20-30% of CPTs in children [ 5 ]. (omicsonline.org)
- Pathological and immunohistochemical studies of choroid plexus carcinoma of the dog. (thefreedictionary.com)
- 3. Patients who have a past or current history of neoplasm other than the entry diagnosis, except for curatively treated non-melanoma skin cancer or carcinoma in situ of the cervix or other cancers treated for cure and with a disease-free survival longer than 5 years. (knowcancer.com)
- The exemptions are primary brain tumors, among which the typical intracranial teratoma was not diagnosed, whereas 2 cases of rarely encountered neoplasms were reported: craniopharyngioma and choroid plexus carcinoma. (medscimonit.com)
- Upendra M. Chowdhary ,Diethelm H. Boehme ,Ali A. Satir , Light microscopic and ultrastructural study of choroid plexus carcinoma, Saudi Med. (who.int)
- Choroid plexus carcinoma or choroid plexus tumor is a type of cancerous tumor that occurs in the brain's choroid plexus tissue and most often occurs in children. (diseaseinfosearch.org)
- Symptoms of choroid plexus carcinoma are similar to those of other brain tumors including frequent headaches, unusually large head due to excess fluid on the brain, or large "soft spots" found on the baby's head. (diseaseinfosearch.org)
- If your baby has been diagnosed with a choroid plexus carcinoma, talk to your baby's doctor and specialists about the most current treatment options. (diseaseinfosearch.org)
- Following organizations serve the condition "Choroid plexus carcinoma" for support, advocacy or research. (diseaseinfosearch.org)
- Finding the right clinical trial for Choroid plexus carcinoma can be challenging. (diseaseinfosearch.org)
- The terms "Choroid plexus carcinoma" returned 27 free, full-text research articles on human participants. (diseaseinfosearch.org)
- Choroid plexus carcinoma with hyaline globules: An unusual histological feature. (diseaseinfosearch.org)
- Choroid plexus carcinoma in adults: an extremely rare case. (diseaseinfosearch.org)
- Imaging findings are not reliable for distinguishing between CPP and choroid plexus carcinoma, which represent about 10% of choroid plexus neoplasms. (uab.edu)
- For example, CNS atypical teratoid/rhabdoid tumor is often misclassified as medulloblastoma, primitive neuroectodermal tumor, or choroid plexus carcinoma ( 1 ). (aacrjournals.org)
Tumor15
- Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
- The most frequent route of choroid plexus tumor spread is via seeding of the CSF. (medscape.com)
- To improve choroid plexus tumor treatment through better understanding of the tumor biology and through increased knowledge about the benefit of specific treatment elements. (clinicaltrials.gov)
- To compare the survival times after cyclophosphamide based treatment with the survival times after carboplatin based treatment in choroid plexus tumor patients. (clinicaltrials.gov)
- There are three graded types of choroid plexus tumor that mainly affect young children. (wikipedia.org)
- Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. (springer.com)
- Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). (wikipedia.org)
- Choroid Cancer, also known as malignant tumor of the choroid , is related to melanoma, uveal and pulmonary aspergilloma . (malacards.org)
- However, the frozen section indicated a choroid plexus tumor, which has a significantly better prognosis. (aao.org)
- see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. (thefreedictionary.com)
- Brain Tumor News: Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children`s Research Hospital experience. (virtualtrials.com)
- Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization (WHO) "Classification of Tumors of the Nervous System. (wikipedia.org)
- Binding of the large T antigen with both p53 and pRb tumor suppressor proteins, forming complexes, has been demonstrated in humans harboring choroid plexus tumors. (statpearls.com)
- Choroid plexus tumors (CPTs) are of epithelial origin, and the most important prognostic factor in human medicine is the tumor grade. (elsevier.com)
- Rather, membranous expression of both molecules was increased in CPTs compared to normal choroid plexus (NCP), regardless of tumor grade. (elsevier.com)
Carcinomas21
- Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
- Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
- Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
- Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
- Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
- According to cellular differentiation, number of mitosis and local invasion, choroid plexus neoplasms can be classified as choroid plexus papillomas or carcinomas (KOESTNER et al. (thefreedictionary.com)
- Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. (springer.com)
- The World Health Organization (WHO) classifies choroid plexus tumors as ranging from more benign papillomas, referred to as WHO Grade I, to carcinomas, referred to as WHO Grade III. (aao.org)
- 2 Excluding rare cases, choroid plexus papillomas of WHO grade I and II are almost always benign, as opposed to choroid plexus carcinomas (WHO grade III), which are malignant. (aao.org)
- Typical choroid plexus carcinomas (CPCs) show variable morphology with a syncytial or solid arrangement. (thefreedictionary.com)
- 57 Choroid plexus tumors are of neuroectodermal origin and range from benign choroid plexus papillomas (CPPs) to malignant choroid carcinomas (CPCs). (malacards.org)
- A total of 39 consecutive patients with pathologically proven CPTs (31 choroid plexus papillomas [CPPs] and 8 choroid plexus carcinomas [CPCs]) were included in this series. (thejns.org)
- The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (uzh.ch)
- According to the 2016 World Health Organization classification, choroid plexus tumors are classified as papillomas (grade I), atypical tumors (grade II) and carcinomas (grade III). (statpearls.com)
- Choroid plexus papillomas have less than two mitotic figures per 10 high power fields, atypical ones have two to five per 10 high power fields, and carcinomas have greater than five mitotic figures per 10 high power fields. (statpearls.com)
- CONCLUSIONS: In TySV40 transgenic mice, intraocular tumors develop that arise at the choroid-RPE interface, and they display morphologic and ultrastructural features consistent with RPE carcinomas. (arvojournals.org)
- Which therapy works better in choroid plexus carcinomas? (elsevier.com)
- Choroid plexus carcinomas (CPCs) are rare tumors with dismal outcome. (elsevier.com)
- Choroid plexus carcinomas in childhood: clinical features and prognostic factors. (naver.com)
- Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which are difficult to distinguish with conventional imaging. (diseaseinfosearch.org)
- In the current study, 42 canine CPTs (19 choroid plexus papillomas and 23 choroid plexus carcinomas) were retrospectively reviewed, and the intensity and cellular staining pattern of E-cadherin and β-catenin were correlated with histological features, paying special attention to grade, invasion, and metastasis. (elsevier.com)
Retina5
- ICD-9 code 239.81 for Neoplasms of unspecified nature, retina and choroid is a medical classification as listed by WHO under the range -NEOPLASMS OF UNSPECIFIED NATURE (239). (aapc.com)
- Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) Iridocyclectomy - Removal of the iris plus the ciliary body muscle. (wikipedia.org)
- Benign tumors of the lid, conjunctiva, iris, and choroid are common, whereas those of the retina and cornea are rare. (nih.gov)
- Although the fluid usually resorbs and leakage stops within days to weeks, it has been suggested that photocoagulation itself somehow weakens the layer between the retina and choroid (Bruch membrane) and in some way may stimulate transformation to malignancy. (nih.gov)
- Other flat lesions in the choroid that have been confused with nevi and melanoma include hyperplasia of the retinal pigment epithelium, hamartomas of the retinal pigment epithelium, and hemorrhages within the retina, especially hemorrhages beneath the retinal pigment epithelium (as part of macular degeneration). (nih.gov)
Melanoma6
- Melanoma is a neoplasm known for its propensity for cardiac involvement. (biomedsearch.com)
- 2. Patients whose site of primary melanoma is not in the choroid(eye). (knowcancer.com)
- The choroid layer is the most likely site of melanoma in the eye. (medlineplus.gov)
- Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. (curehunter.com)
- The study found that the pigmented neoplasms were ranked in the first place of ciliary body tumors, in which melanoma of ciliary body were majority. (arvojournals.org)
- Symptomatic impairment of urine transport after malignant melanoma of the choroid]. (nih.gov)
Intracranial neoplasms5
- [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
- Choroid plexus tumours (CPT) are intracranial neoplasms derived from the choroid plexus epithelium. (springer.com)
- Choroid plexus tumors (CPTs) are rare intracranial neoplasms that constitute approximately 2%-5% of all pediatric brain tumors. (thejns.org)
- Schwannomas account for up to 8% of intracranial neoplasms (14). (upmc.edu)
- In the pediatric population, they form the third most common congenital brain tumors, after teratomas and gliomas, and account for 0.4 to 0.6% of all intracranial neoplasms. (statpearls.com)
Ependymoma1
- As a group, gliomas are the most common primary central nervous system (CNS) neoplasms in both adult and pediatric populations, whereas infiltrative gliomas, in particular glioblastoma, make up the bulk of adult glial tumors, pilocytic astrocytoma, and ependymoma predominate in children. (hindawi.com)
Epithelium7
- Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
- It should be pointed out, however, that TTR is not entirely specific for choroid plexus neoplasms , since TTR immunoreactivity has been documented in several other neoplasms, retinal pigment epithelium, and hepatocytes. (thefreedictionary.com)
- The epithelium of the choroid plexus is continuous with the ependymal cell layer that lines the ventricles, but unlike the ependyma, the epithelial layer has tight junctions between the cells on the side facing the ventricle (apical surface). (wikipedia.org)
- We show here that c-MYC overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. (springer.com)
- WDPs have a consistent ocular phenotype of photophobia, hypopigmented adnexal structures, blue irides with a tan periphery and hypopigmented retinal pigment epithelium and choroid. (jove.com)
- PURPOSE: To characterize intraocular tumors that arise by in situ transformation in the choroid-retinal pigment epithelium (RPE) in transgenic mice bearing the SV40 oncogene under the control of the mouse tyrosinase promoter. (arvojournals.org)
- Choroid plexus tumors are rare intraventricular papillary neoplasms derived from choroid plexus epithelium, which account for approximately 2% to 4% of intracranial tumors in children and 0.5% in adults. (diseaseinfosearch.org)
Ciliary6
- These tumors can occur in the choroid, iris and ciliary body. (wikipedia.org)
- Even less common are melanocytomas originating in the choroid, ciliary body, or iris. (nih.gov)
- By analyzing the histogenesis and classification, histopathologic characteristics, clinical feature and the key point of differential diagnosis of ciliary body neoplasms, the study provided the basis for clinical diagnosis and treatment. (arvojournals.org)
- Eighty-three specimens of ciliary body neoplasms on file (1959∼2005) were analyzed and studied for the characteristics of location, histogenesis, clinical presentation and histopathology. (arvojournals.org)
- 18 cases were melanocytoma, occupied 21.7% of the ciliary body neoplasms and 42.9% of the pigmented tumors. (arvojournals.org)
- By further recognizing the clinical features and histopathologic characteristics of ciliary body neoplasms, it may help clinical ophthalmologists to make correct diagnosis and proper treatment. (arvojournals.org)
Diagnosis5
- Although BFH of the choroid is very rare, its benign nature and the availability of choroidal biopsy for tissue diagnosis make it important to include this as one of the differential diagnoses for amelanotic choroidal mass. (elsevier.com)
- The radiologic finding of erosion of the skull base by this mass lesion may have contributed to its interpretation as a destructive neoplasm, with the differential diagnosis including chondrosarcoma, metastatic lesion, osteosarcoma, and meningioma. (thefreelibrary.com)
- However, the histology in this case ruled out a diagnosis of neoplasm. (thefreelibrary.com)
- The authors present the case of a child with partial trisomy 9p and delayed diagnosis of hydrocephalus with radiographic evidence of DVHCP who was successfully managed with ventriculoperitoneal shunt (VPS) placement, adjuvant bilateral endoscopic choroid plexus coagulation (CPC), and the novel application of anterior choroidal artery embolization. (thejns.org)
- The histological diagnosis was that of choroid. (who.int)
Pediatric5
- In the pediatric population, the most common intradural extramedullary neoplasms are leptomeningeal metastases resulting from primary brain tumors whereas in adults non-CNS tumors are most commonly encountered. (radiopaedia.org)
- Radiologic-pathologic correlation of pediatric and adolescent spinal neoplasms: Part 2, Intradural extramedullary spinal neoplasms. (radiopaedia.org)
- BACKGROUND: Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. (virtualtrials.com)
- Background: Congenital tumors form a unique group among pediatric neoplasms. (medscimonit.com)
- Pediatric choroid plexus neoplasms. (naver.com)
Metastasis2
- The TySV40 transgenic murine tumors represent potentially useful tools for investigations into the biology and metastasis of intraocular neoplasms. (arvojournals.org)
- Although detailed systemic examinations were performed, no metastasis to lymph nodes or distant organs except the choroid plexus was detected, which is very rare in a case of stage IV primary lung cancer. (elsevier.com)
Hyperplasia of the choroid plexus2
- Duplication of 9P and hyperplasia of the choroid plexus: a pathologic, radiologic, and molecular cytogenetics study. (springer.com)
- Diffuse villous hyperplasia of the choroid plexus (DVHCP) is a rare cause of communicating hydrocephalus. (thejns.org)
Patients with choroid plexus tumors2
- TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. (springer.com)
- Young patients and patients with choroid plexus tumors appear to have an increased risk of SNs that is associated with genetic factors. (virtualtrials.com)
Meningioma1
- Notice the en plaque meningioma anterior to the brainstem. (medscape.com)
Third ventricle2
- The third ventricle is the least common intraventricular location for choroid plexus neoplasms, irrespective of patient age. (medscape.com)
- We present a case of xanthogranuloma of the choroid plexus of the third ventricle, causing obstructive hydrocephalus of the lateral ventricles. (elsevier.com)
Neuroendocrine2
- Neuroendocrine neoplasms are tumors of various location and symptoms. (enets.org)
- Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) represent a group of uncommon, but clinically significant diseases. (enets.org)
CPPs2
- Choroid plexus papillomas (CPPs) are rare central nervous system tumors. (statpearls.com)
- Objective: To determine the long-term outcome of resected choroid plexus papillomas (CPPs). (naver.com)
Rare tumors2
- Choroid plexus tumors (CPT) are rare tumors of the neuroepithelial tissue of the brain that are most common in young children. (springer.com)
- Choroid plexus papillomas are rare tumors of neuroectodermal origin. (statpearls.com)
Resected choroid plexus tumors1
- To compare response rates of incompletely resected choroid plexus tumors to two blocks of cyclophosphamide based treatment with the response rates after two blocks of carboplatin based treatment. (clinicaltrials.gov)
Adult2
- Clinical outcome of adult choroid plexus tumors: retrospective analysis of a single institute. (springer.com)
- The human IGF-II gene is maternally imprinted in all tissues except adult liver and the choroid plexus/leptomeninges of the central nervous system where IGF-II is biallelically expressed. (elsevier.com)
Choroidal1
- Choroidal neoplasms are tumors of the choroid of the eye. (utah.edu)
Epithelial4
- The choroid plexus consists of many capillaries, separated from the ventricles by choroid epithelial cells. (wikipedia.org)
- it is composed of epithelial cells of the choroid plexus at the peripheral blood-CSF boundary and the arachnoid membrane at the cerebral blood-CSF boundary. (wikipedia.org)
- Choroid plexus tumors (CPTs) are rare, intraventricular neoplasms that originate from the epithelial cells of the choroid plexus [ 1 - 4 ]. (omicsonline.org)
- MIB-1 immunoreactivity reveals different labelling in low-grade and in malignant epithelial neoplasms of the choroid plexus. (uzh.ch)
Hydrocephalus1
- 2 Choroid plexus papillomas cause the choroid plexus to overproduce CSF, and they can block normal CSF circulation, which leads to hydrocephalus. (aao.org)
Central nervous s2
- Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). (bioportfolio.com)
- The new WHO classification introduces 7 changes in the grading of central nervous system neoplasms, ranging in significance from minor to major, in categories of anaplastic oligoastrocytomas, meningiomas, choroid plexus tumors, pineal parenchymal tumors, ganglioglioma, cerebellar liponeurocytoma, and hemangiopericytomas. (elsevier.com)
Tumors are rare1
- Malignant rhabdoid tumors are rare, highly aggressive neoplasms found most commonly in infants and young children. (aacrjournals.org)
Histology1
- Histology and extent of surgical resection are prognostic for choroid plexus tumors. (springer.com)
Common intraventricular1
- Neuroradiologically, intraventricular schwannomas cannot be differentiated with certainty from other, more common intraventricular neoplasms such as ependymal and choroid plexus tumors. (upmc.edu)
Abstract2
- abstract = "Intracranial xanthogranulomas are rare benign tumors and occur most commonly as choroid plexus xanthogranulomas, which rarely become symptomatic. (elsevier.com)
- abstract = "A 20-month-old infant found to have a blind eye with neovascular glaucoma was thought to have a neoplasm of the optic nerve for which enucleation was performed with resection of a long segment of optic nerve. (elsevier.com)
Cases of choroid1
- We expanded a pre-existing database and included all cases of choroid plexus tumors, identified in PubMed through the end of 2007, for a total of 906 patients. (elsevier.com)
Intraventricular neoplasms1
- Intraventricular neoplasms are uncommon, representing just 1-10% of all CNS tumors ( 1 - 4 ). (ajnr.org)
Lateral ventricles2
- Choroid plexus is present in all components of the ventricular system except for the cerebral aqueduct, the frontal horn and the occipital horn of the lateral ventricles. (wikipedia.org)
- Choroid plexus papillomas (CPP) are very rare and are commonly found in the lateral ventricles (LV) in children. (minervamedica.it)
Methylation2
- Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. (springer.com)
- BAP1 expression in unaffected choroid tissue from a patient with UM was assessed by quantitative RT-PCR and methylation by pyrosequencing. (cdc.gov)
Intraocular tumors2
- most common intraocular tumors are malignant melanomas of the choroid . (lookfordiagnosis.com)
- The most common intraocular tumors are in fact, malignant melanomas of the choroid which increase in frequency as we age. (utah.edu)
