Choroid Neoplasms: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).Choroid Plexus: A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.Choroid: The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.Choroid Plexus Neoplasms: Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)Papilloma, Choroid Plexus: A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Choroid Diseases: Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.Cerebral Ventricle Neoplasms: Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Skin Neoplasms: Tumors or cancer of the SKIN.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Uvea: The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)Kidney Neoplasms: Tumors or cancers of the KIDNEY.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Ependyma: A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.Eye Neoplasms: Tumors or cancer of the EYE.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Sclera: The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.DNA, Neoplasm: DNA present in neoplastic tissue.Lung Neoplasms: Tumors or cancer of the LUNG.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Ornithine-Oxo-Acid Transaminase: A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 188.8.131.52.Liver Neoplasms: Tumors or cancer of the LIVER.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Ciliary Body: A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Meninges: The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Lymphoma, T-Cell, Peripheral: A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Lymphoma, T-Cell: A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.Artificial Cells: Chemically synthesized structures which functionally resemble natural cells.Dermoid Cyst: A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)Cerebellar Ataxia: Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)Brachial Plexus: The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Ultrasonic characterisation of malignant melanoma of choroid. (1/324)An in-vitro study of wave spectral analysis in 8 enucleated eyes was conducted in order to differentiate histological subtypes of malignant melanoma. To obtain the backscattering coefficient for the tissues, we used a broadband focussed transducer with a frequency range of 7-12 MHz and a centre frequency of 10 MHz. Experimental measurement of backscattering coefficient and attenuation coefficient at various frequencies was done by substitution techniques. The backscattering coefficient, scatterer size, and root mean square velocity fluctuation were derived by the numerical method, while the attenuation coefficient at 1 MHz was derived from attenuation coefficient at different frequencies. This study revealed that backscattering coefficient and attenuation coefficient, over a frequency range of 7-12 MHz, show an increase in the spindle cell type compared to the mixed cell type of malignant melanoma. Particularly, the scatterer size was significantly higher in the spindle cell group (p = 0.013) in contrast to the mixed cell type. Spindle cells have uniform and compact histological pattern which contributes to an increase in scatterer size and root mean square velocity fluctuation. The ultrasonically obtained parameters have been shown to have a good correlation with the histology of malignant melanoma. (+info)
Radioactive phosphorus uptake testing of choroidal lesions. A report of two false-negative tests. (2/324)Two false-negative results from 32P testing for histologically verified malignant melanomas of the choroid are reported. In the first case, a haemorrhagic choroidal detachment caused an increase in probe; additionally, the tumour was necrotic. Both factors are likely to have contributed to the false-negative result. A satisfactory explanation for the false-negative result in the second case was not determined, although it may have accurately reflected a period of minimal tumour activity, inasmuch as repeat 32P testing was strongly positive eight months later, when unequivocal evidence of tumour growth was present. An alternative explanation is that the orally administered 32P was incompletely absorbed. Since 32P testing is frequently accompanied by significant manipulation both in the manoeuvre associated with tumour localization and in that associated with the actual radioactive counting, it would seem desirable to perform indicated enucleation immediately after completion of the 32P testing. While the properly performed 32P test remains a valuable diagnostic test for helping to establish the presence or absence of malignancies of the posterior globe, it is important to guard against the tendency to underestimate careful clinical evaluation. (+info)
Combination chemotherapy for choroidal melanoma: ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside. (3/324)Treatment of choroidal melanoma by chemotherapy is usually unsuccessful, with response rates of less than 1% reported for dacarbazine (DTIC)-containing regimens which show 20% or more response rates in skin melanoma. Recently, we reported the activity of several cytotoxic agents against primary choroidal melanoma in an ATP-based tumour chemosensitivity assay (ATP-TCA). In this study, we have used the same method to examine the sensitivity of choroidal melanoma to combinations suggested by our earlier study. Tumour material from 36 enucleated eyes was tested against a battery of single agents and combinations which showed some activity in the previous study. The combination of treosulfan with gemcitabine or cytosine arabinoside showed consistent activity in 70% and 86% of cases, respectively. Paclitaxel was also active, particularly in combination with treosulfan (47%) or mitoxantrone (33%). Addition of paclitaxel to the combination of treosulfan + cytosine analogue added little increased sensitivity. For treosulfan + cytosine arabinoside, further sequence and timing experiments showed that simultaneous administration gave the greatest suppression, with minor loss of inhibition if the cytosine analogue was given 24 h after the treosulfan. Administration of cytosine analogue 24 h before treosulfan produced considerably less inhibition at any concentration. While we have so far been unable to study metastatic tumour from choroidal melanoma patients, the combination of treosulfan with gemcitabine or cytosine arabinoside shows activity ex vivo against primary tumour tissue. Clinical trials are in progress. (+info)
Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance. (4/324)We evaluated 55 samples of choroidal melanoma managed by enucleation. Knowing that the immunohistochemical expression of the retinoblastoma gene family members Rb/p105, p107, and pRb2/p130 was inversely correlated with the degree of malignancy in at least some histological types, we investigated the expression of these three proteins in choroidal melanoma. We focused on the relationship between patient survival and the immunohistochemical detection of the retinoblastoma proteins. No correlation with clinical outcome was found for Rb/p105 and p107. However, we found pRb2/p130 to be an independent prognostic factor correlating positively or directly with patient survival times and indirectly or inversely with the degree of malignancy. Demonstration of the prognostic value of the immunohistochemical expression of pRb2/p130 is of significance, even if additional studies are required to confirm these data and to compare the prognostic value of pRb2/p130 immunodetection to that of other recently proposed markers, such as p53. (+info)
Alpha/beta- and gamma/delta TCR(+) lymphocyte infiltration in necrotising choroidal melanomas. (5/324)AIM: To detect specific tumour infiltrating T cells (TIL) carrying antigen specific MHC-I restricted receptor genes on necrotising and non-necrotising malignant melanomas and to correlate the findings with clinical data. METHODS: alpha/beta- and gamma/delta- TIL were determined by immunohistochemical staining in melanomas of patients with known follow up of more than 10 years. An antigen retrieval method was used to determine variable genes delta1 and gamma1 on TCR(+) cells by an anti-TCR Vdelta1 and anti-CrgammaM1, and of Valpha and Vbeta TCR(+) by an anti-pan-TCR(+) alpha/beta antibody. RESULTS: Intratumoral TIL were present in 86 of 113 (76.1%) necrotising melanomas (NMM) v 21 of 100 (21%) in non-necrotising melanomas (MM); of these, Valpha/beta- TCR(+) cells were present in 52 of 74 (70.3%) TIL harbouring NMM v four of 21 (19%) MM; Vgamma1 in 29 of 74 (39.2%) NMM v two of 21 (10%) MM; and Vdelta1 in 39 of 74 (52.7%) NMM v three of 21 (14%) MM. Extratumoral lymphocytic infiltration was seen in 86 (76.1%) NMM including Valpha/beta TCR(+) cells in 10 (11.6%) cases, v five (5%) MM cases with no Valpha/beta TCR(+) cells detected. Vgamma1 and Vdelta1 TCR(+) cells were not found in extratumoral infiltrates. CONCLUSIONS: In NMM, the median survival was 69.3 (range 6-237) months, 19 of 74 patients (25.7%) survived 5 years, and mortality was associated with advanced stage (p<0.001), patient age (p<0.023), and extent of necrosis (p<0.048). Survival was increased with evidence of Vgamma1 and Vdelta1 TCR(+) cells (p<0.026). (+info)
Microvascular density in predicting survival of patients with choroidal and ciliary body melanoma. (6/324)PURPOSE: Although malignant uveal melanoma disseminates predominantly hematogenously because of the absence of intraocular lymphatics, consensus about prognostic impact of microvascular density (MVD) has not been reached. This study was undertaken to investigate whether MVD, microvascular patterns, or both determine prognosis of uveal melanoma. METHODS: A population-based retrospective cohort study of melanoma-specific and all-cause mortality of 167 consecutive patients who had an eye enucleated because of choroidal or ciliary body melanoma from 1972 through 1981 was conducted. MVD was determined by counting tumor vessels in a masked fashion from areas of highest vessel density after immunostaining for CD34 epitope, factor VIII-related antigen (FVIII-RAg), and alpha-smooth muscle actin (SMA). Kaplan-Meier and Cox regression analyses of survival were performed. The association between MVD and tumor size and location, cell type, and microvascular patterns was assessed. RESULTS: MVD could be determined from 134 of 167 melanomas (80%). Based on globally highest count obtained with antibodies to CD34, MVD ranged from 5 to 121 vessels/0.313 mm2 (median, 40) and its association with presence of microvascular loops and networks (P = 0.0006), epithelioid cells (P = 0.028), and largest basal tumor diameter (P = 0.0029) was statistically significant. The 10-year melanoma-specific mortality increased with MVD (0.09, 0.29, 0.59, and 0.64, according to quartiles; P < 0.0001), as did all-cause mortality (P = 0.0022). Equivalent results were obtained with immunostaining for FVIII-RAg, whereas MVD obtained with antibodies to SMA was not associated with prognosis. Cox regression showed a hazard ratio of 2.45 (95% CI, 1.43-4.18) for presence of epithelioid cells, 1.11 (95% CI, 1.03-1.20) for largest basal diameter, 1.23 (95% CI, 1.06-1.43) for square root-transformed MVD, and 1.51 (95% CI, 1.09-2.10) for presence of loops and networks, all of which independently contributed to prognosis. CONCLUSIONS: The findings support the theory that both MVD and microvascular patterns contribute independently to prognosis in uveal melanoma in addition to cell type and size of the tumor. (+info)
Ocular arterial blood flow of choroidal melanoma eyes before and after stereotactic radiotherapy using Leksell gamma knife: 2 year follow up. (7/324)AIMS: To evaluate the effect of high dose stereotactic radiotherapy on the ocular blood flow of patients with uveal melanoma. METHODS: Colour Doppler imaging (CDI) was used to measure blood flow velocity and vascular resistance in the ophthalmic, short posterior, and central retinal arteries of nine patients suffering from uveal melanoma. The measurements were taken before, 6 months, 1 year, and 2 years after stereotactic radiotherapy. Irradiation was performed with the Leksell gamma knife with the 59 (41-66.5) Gy total marginal dose divided in two equal fractions. CDI results were compared with age and sex matched healthy control eyes. RESULTS: At each time of measurement, blood flow velocity in the central retinal artery of the affected eyes was significantly reduced whereas vascular resistance was only increased at the 2 year follow up. Blood flow velocity and vascular resistance in the short posterior arteries of melanoma eyes were also only significantly altered at the 2 year follow up. Blood flow velocity and vascular resistance in the ophthalmic artery of melanoma eyes were not changed at all follow ups. CONCLUSIONS: In the melanoma eyes, blood flow velocity in the central retinal artery is reduced. High dose stereotactic radiotherapy with the Leksell gamma knife and a 59 (41-66.5) Gy total marginal dose in two fractions leads to a significant reduction of blood flow and a significant increase in resistance variables in the small ocular arteries within 2 years. (+info)
Transpupillary thermotherapy as primary treatment for small choroidal melanomas. (8/324)PURPOSE: To report short-term follow-up of eyes containing small choroidal melanomas that were treated with transpupillary thermotherapy (TTT). METHODS: Twenty eyes with suspected small choroidal melanomas were treated with TTT using infrared light delivered from the diode laser. RESULTS: The age of patients ranged from 26 to 82 years. In 14, there was documented growth of the melanoma prior to TTT. Tumor thicknesses ranged from less than 1 to 3.2 mm. Seven tumors were treated more than once. Follow-up ranged from 6 months to more than 3 years. Following treatment, tumor thicknesses decreased in all cases, usually within 2 months. Progressive atrophy of tumor mass and loss of pigmentation within the tumor continued beyond 1 year of follow-up in some eyes. Complications included field defects, vascular changes, and macular abnormalities. CONCLUSIONS: Transpupillary thermotherapy of small choroidal melanomas is usually followed by early tumor shrinkage but is complicated by dense scotomas, nerve fiber bundle defects, and occasionally macular abnormalities. Short-term follow-up suggests that TTT may arrest growth of selected small melanomas. (+info)
Malignant Choroidal Melanoma
Imagen de PET/CT de melanoma coroideo metastásico
CARTAS/Opinión. PET/CT imaging for metastatic choroidal melanoma. Imagen de PET/CT de melanoma coroideo metastásico. Correspondence. Dear Director:. The report on «Whole body PET/CT imaging metastatic choroidal melanoma»1 is very interesting. Rodríguez-Marco et al concluded that «PET/CT is a sensitive tool for the detection and localization of hepatic and extrahepatic metastatic choroidal melanoma»1. In fact, PET/CT is confirmed for its usefulness in following up choroidal melanoma. Finger et al. noted that «PET/CT imaging may improve upon the conventional methods of screening for detection of metastatic disease in patients initially diagnosed with choroidal melanoma»2. Kurli et al also proposed that «same conclusion» as Rodríguez-Marco et al that PET/CT is «is a sensitive tool for the detection and localization of hepatic and extra-hepatic (particularly osseous) metastatic choroidal melanoma»3. However, the limitation of using PET/CT in melanoma is still observed. As noted by Keu ...
Bilateral Choroidal Metastasis as Initial Presentation of Parotid Gland Adenoid Cystic Carcinoma | Abstract
medicine: CHOROIDAL MELANOMA
The malignant choroidal melanoma, in contrast, appears as a mottled, often significantly elevated lesion, ranging in coloration from white to greenish-gray. As it grows, it may break through Bruchs membrane, taking on a mushroom-like appearance. Serous retinal detachments are commonly associated with this presentation. You may also observe overlying orange pigmentation known as lipofuscin. Most malignant melanomas are over 10 DD in size at the time of diagnosis. Most patients with choroidal melanomas are asymptomatic. However, should a significantly large lesion occur in proximity to the macula, the patient may present with metamorphopsia, acuity loss, visual field deficit and/or a hyperopic refractive shift ...
A Case Report of Choroidal Metastasis from Renal Cell Carcinoma during Sunitinib Treatment: A Tumor Pharmacologic Sanctuary |...
Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss
We report a patient with bilateral choroidal metastasis from disseminated cervical squamous cell carcinoma. A 52-year-old woman presented with progressive bilateral visual loss due to choroidal masses in both eyes. The fundus examination revealed posterior serous retinal detachment in both eyes associated with creamy choroidal lesions. A thorough systemic work-up revealed choroidal metastasis from a squamous cell carcinoma of the cervix. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours.
Uveal Choroidal Melanoma - Uveal Choroidal Melanoma - Retina Gallery ~ Full Sized Retina Images
Uveal Choroidal Melanoma - Uveal Choroidal Melanoma - Retina Gallery ~ Full Sized Retina Images
GO Guide Topics - American Academy of Ophthalmology
Endoresection for choroidal melanoma: palliative or curative intent? | British Journal of Ophthalmology
There seems to be perpetual controversy surrounding treatment of uveal melanoma since publication of a landmark article by Zimmerman, McLean, and Foster in this journal titled "Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells."1 Over the last 30 years, we have come to realise the limitations of the "Zimmerman-McLean-Foster hypothesis"2 and observed that for comparable-sized tumours, survival is independent of the method of treatment such as plaque radiotherapy, enucleation and proton-beam radiotherapy.3 4 Survival is perhaps similar with trans-scleral resection (TSR), although there are no randomised trials comparing survival following TSR with other methods of treatment.5. These observations imply that distant metastasis of choroidal melanoma, although undetectable at the time of ocular diagnosis by present-day imaging techniques, has perhaps taken place prior to the treatment of primary tumour. This concept is further supported ...
The COMS Randomized Trial of Iodine 125 Brachytherapy for Choroidal Melanoma: V. Twelve-Year Mortality Rates and Prognostic...
Choroidal Melanoma and Lid Fibrofoliculomas in Birt-Hogg-Dubé Syndrome
What is the role of systemic chemotherapy in the treatment of choroidal melanoma?
choroidal melanoma - Texas Retina Associates
Taxoprexin® Treatment for Advanced Eye Melanoma - Full Text View - ClinicalTrials.gov
This is a Phase II open-label study of weekly Taxoprexin® Injection in patients with metastatic choroidal melanoma who may be previously untreated or have received one prior systemic cytotoxic regimen for advanced disease. Patients may not have been treated previously with taxanes. Patients may have been previously treated with immunological agents including IL-2 and vaccines. Patients will receive Taxoprexin® Injection at a dose of 500mg/m2 intravenously by 1-hour infusion weekly for the first five weeks of a six week cycle. Treatment will continue until progression of disease, intolerable toxicity, refusal of continued treatment by patient or Investigator decision ...
Choroidal Melanoma | Clinical Gate
The most common appearance is a pigmented, elevated choroidal lesion that will enlarge without treatment (Fig. 21.2.1 and Fig. 21.2.2). Without documented growth, features such as overlying lipofuscin (orange pigment), associated subretinal fluid, larger size, and proximity to the optic nerve help to differentiate from benign lesions such as choroidal nevus. On a clinical basis, the diagnosis can be made with greater than 99% accuracy. Biopsy is rarely necessary, but can confirm the diagnosis. Radiation retinopathy can often develop after treatment with external radiation (Fig 21.2.3).. ...
Chiefs Rounds - 62yo male with pigmented choroidal lesion OS
Chiefs Rounds Presenter: Michael Abendroth, MD - Wills Eye Hospital Resident On Friday mornings at 7AM, tables are turned during Chiefs Rounds. Two cases are presented as unknowns by the residents to the Service Chiefs and Attending Staff. Chiefs Rounds provide a chance for the residents to see their Attending Staff think through the clinical presentation, differential diagnosis, and management of a difficult case. This approach invariably leads to a lively discussion among the staff and remains a vital teaching tool in resident education.. ...
Choroidal Tumor Excision - American Academy of Ophthalmology
Sonography and colour Doppler of choroidal melanoma ocular - ARRS GoldMiner®
Melanoma - UCLA Health Eye Care - Los Angeles, CA
Choroidal melanoma is the most common primary tumor of the eye in adults. It is usually a pigmented tumor that grows in the blood-vessel layer (choroid) beneath the retina. Choroidal melanoma has no specific symptoms; it is usually detected during a routine eye examination. If untreated, this cancer can spread to other parts of the body. It is best evaluated and treated by ophthalmologists experienced in this subspecialty.. ...
Retinal Tumours and Pigmented Lesions
With increasing use of indirect ophthalmoscopy and retinal imaging systems it is increasingly common to find pigmented and non-pigmented retinal or choroidal lesions in a routine eye examination. In the vast majority of cases pigmented lesions are benign choroidal naevi, but the alternative; a choroidal melanoma is a life-threatening, potentially-metastatic tumour that can sometimes be difficult to distinguish from a naevus.. Understanding which lesions to refer and which can be monitored is vital in providing good patient care. In this article we will review the prevalence, aetiology, differential diagnosis and treatment of the most common forms of pigmented fundus lesions and ocular tumours and offer advice on management for optometrists.. ...
Journal of Datta Meghe Institute of Medical Sciences University - Choroidal melanoma in a young patient ultrasonography and...
choroidal melanoma | British Journal of Ophthalmology
aura - Texas Retina Associates
2007 - Volume CV (v.105)
The Relationship Between Combined Positron Emission Tomography/Computed Tomography Findings And Light Microscopic Findings In Cases Of Choroidal Melanoma Lisa J. Faia MD*, Jose S. Pulido MD MS MPH MBA, Mark J. Donaldson MBBS (Hons), Diva R. Salomao MD, J. Dougnas Cameron MD, Brian Mullan MD, and Kaan Gunduz MD. ...
Primary choroidal and cutaneous melanomas, bilateral choroidal melanomas, and familial occurrence of melanomas<...
TY - JOUR. T1 - Primary choroidal and cutaneous melanomas, bilateral choroidal melanomas, and familial occurrence of melanomas. AU - Oosterhuis, J. A.. AU - Went, L. N.. AU - Lynch, H. T.. PY - 1982/1/1. Y1 - 1982/1/1. N2 - The medical history of a patient with a familial atypical multiple mole melanoma syndrome revealed a combination of rare findings: occurrence of a melanoma in both eyes, development of 3 separate skin melanomas, and occurrence of other malignancies in the family. Another patient developed a choroidal and a skin melanoma, but there were no known malignancies in the family. A third patient with a choroidal melanoma had a mother with an ethmoidal melanoma.. AB - The medical history of a patient with a familial atypical multiple mole melanoma syndrome revealed a combination of rare findings: occurrence of a melanoma in both eyes, development of 3 separate skin melanomas, and occurrence of other malignancies in the family. Another patient developed a choroidal and a skin melanoma, ...
CyberKnife radiosurgery in four cases of choroidal malignant melanoma<...
TY - JOUR. T1 - CyberKnife radiosurgery in four cases of choroidal malignant melanoma. AU - Tabira, Emi. AU - Yoshikawa, Hiroshi. AU - Kawano, Yoh Ichi. AU - Ueno, Ichiro. AU - Kohno, Ri Ichiro. AU - Hasegawa, Yuhei. AU - Ishibashi, Tatsuro. PY - 2010/11/15. Y1 - 2010/11/15. N2 - Purpose : To report four cases who received CyberKnife radiosurgery for choroidal malignant melanoma. Cases : CyberKnife radiosurgery was performed on 4 cases of choroidal malignant melanoma. The series comprised 3 males and one female. The age ranged from 57 to 82 years. The height of the tumor ranged from 2.8 to 6.7 mm, average 5.3 mm. Each eye received a case 10 Gy of radiation per session totaling 50 Gy after 5 sessions. The tumor showed a decrease in size. The height ranged 0.2 to 5.2 mm, average 3.9 mm after 6 to 36 months of treatment. One eye developed vitreous hemorrhage. Otherwise, there was no local recurrence or rubeotic glaucoma. Conclufion : CyberKnife radiosurgery was effective in four cases of choroidal ...
Enucleation After Iodine-125 Plaque Brachytherapy in Patients with Large Choroidal Melanomas | IOVS | ARVO Journals
Purpose: Treatment of choroidal melanoma (CMM) with either iodine-125 (I125) plaque brachytherapy or enucleation yields similar survival outcomes. As such, we have used brachytherapy as primary treatment for large CMMs for more than a decade. Herein, we evaluate our cohort of patients with large CMM initially treated with plaque brachytherapy to determine rate of and factors associated with secondary enucleation.. Methods: A retrospective chart review of patients with large CMMs diagnosed and treated at our institution from January 1, 1988 to February 1 2013. Main outcome measures were need for secondary enucleation, local tumor recurrence, all cause mortality, development of metastases, initial apical tumor height and maximal basal diameter.. Results: 245 patients with large CMM were treated primarily with plaque brachytherapy. Local control was achieved in 230 patients (93.8%). Of the 15 patients (6.2%) with local recurrence, 8 underwent secondary enucleation and 7 deferred further treatment. ...
Controlled hypotension in adults undergoing choroidal melanoma resection: comparison between the efficacy of nitroprusside and...
BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a dry operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. Choroidal blood flow decreased by 24 +/- 0.3% and 22 +/
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma - Full Text...
Melanoma arising from the choroid and ciliary body is the most common primary intraocular cancer. The Collaborative Ocular Melanoma Study (COMS) randomized clinical trial of I-125 brachytherapy versus enucleation for medium-sized choroidal melanoma (2.5-10.0 mm in thickness and ≤ 16 mm in diameter) showed that, for patients who met the eligibility criteria, there was no statistically significant difference in all-cause mortality between I-125 brachytherapy and enucleation 5, 10, and 12 years following treatment. The COMS trial supported the use of globe-conserving I-125 brachytherapy. Following brachytherapy, however, visual acuity in the treated eye generally declined at a rate of approximately 2 lines of visual acuity per year and nearly 45% of patients lost ambulatory vision (≤20/200) in the treated eye by 3 years.. Adverse effects of plaque brachytherapy include cataract, radiation-associated proliferative retinopathy, maculopathy and papillopathy. Radiation maculopathy, which may result ...
Gamma Knife Perfexion® radiosurgery and endo diode laser thermotherapy for choroidal melanoma with technical analysis: A case...
TY - JOUR. T1 - Gamma Knife Perfexion® radiosurgery and endo diode laser thermotherapy for choroidal melanoma with technical analysis. T2 - A case report. AU - Tsai, Yi Chieh. AU - Kuo, Chun Yuan. AU - Lin, Jia Wei. AU - Yang, Shung Tai. AU - Lai, Shih Chung. AU - Tsai, Jo Ting. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Radiosurgery serves an important function in the treatment of patients with intraocular tumors and preserves visual function via organ conservation. Therefore, it is important to ensure the safety and precision of GK-SRS as a primary treatment for intraocular tumors. The present case study described a 57-year-old female with uveal melanoma treated with GK-SRS. Retrobulbar anesthesia following fixation of the treated eye, via the suture of two of the extraocular muscles to the stereotactic frame, was performed to immobilize the eye during treatment. Computed tomography (CT) scans were performed following eye fixation, immediately prior to and following GK-SRS, to validate the accuracy ...
PURPOSE: To report on the heterogeneity of monosomy 3 in a fine needle aspiration biopsy obtained transsclerally from choroidal melanoma for prognosis. METHODS: All clinical records for patients who had been diagnosed with choroidal melanoma and underwent iodine-125 plaque brachytherapy with intraoperative transscleral fine needle aspiration biopsy from January 2005 to August 20, 2011, and who had a positive result for monosomy 3 according to fluorescence in situ hybridization as reported by clinical cytogenetics testing were collected. Patient age and sex, total number of cells evaluated and number of cells positive for monosomy 3, tumor size, and metastatic outcome were recorded for each patient. RESULTS: A positive result for monosomy 3 was reported in 93 patients who underwent transscleral fine needle aspiration biopsy. Two patients were lost to follow-up immediately post-operatively, and the remaining 91 patients were included in this study. The mean number of cells evaluated in the biopsy ...
Optical coherence tomography of retinal and choroidal tumors.
Retina Today - The Current Management of Choroidal Hemangioma (November/December 2010)
The decision to treat circumscribed hemangiomas is based on the location, size and related ocular symptoms.4 Shields and coworkers4 reported 200 patients with circumscribed choroidal hemangioma and found that the most common cause for decreased vision was chronic subretinal fluid and chronic macular edema. Optical coherence tomography can be useful in detecting subtle subretinal fluid (Figure 2C) and retinal edema (Figure 2D). Asymptomatic hemangiomas that demonstrate no related subretinal fluid are managed by observation. Hemangiomas with advanced visual deficit and minimal anticipated visual potential can also be observed but it should be understood that progressive subretinal fluid could lead to neovascular glaucoma and ultimate need for enucleation.4 The available treatment modalities are detailed below.. Laser photocoagulation (Xenon or Argon). Laser photocoagulation has been an effective treatment modality for hemangioma for many years. Shields and coworkers4 reported 62% resolution of ...
Choroidal Hemangioma - What You Need to Know
Tratam inapoi de la osteochondroza
Helioxae dans la tramontane DOMDGR30. Coloque la cabeza hacia atrás y. To determine regional percentile values and compare them with currently used national and international curves, we determined the birth weight, height and head and chest circumference of 3688 term neonates born in a state hospital in the Anatolian part of Istanbul, Turkey. John Kennedy is a world- renowned orthopedic surgeon specializing in sports- related injuries including fractures and soft tissue injuries of the foot and ankle. Kennedy has long been sought after by recreational athletes and elite professional players alike. No apoye el extremo del envase sobre el ojo, el párpado u otras áreas de la piel. Choroidal osteoma are usually found near the optic nerve and can cause vision loss. Zomacton is a form of human growth hormone important for the growth of bones and muscles. Finger, MD Description Choroidal osteoma can grow within the eye. Household sharing included. No use lentes de contacto mientras utiliza este ...
A clinically challenging diagnosis of adenoma of the retinal pigment epithelium presenting with clinical features of choroidal...
BACKGROUND: Adenoma of the retinal pigment epithelium (RPE) is a rare intraocular tumor that can simulate other pigmented tumors such as choroidal melanoma. We report a case of non-pigmented adenoma of the RPE initially diagnosed as choroidal hemangioma. CASE REPORT: A 42-year-old woman presented to Kurume University Hospital in November 1992 with an orange-yellow tumor nasal to the optic disc in the left fundus. The tumor was 9.0 × 9.0 mm in diameter, 6.0 mm thick, and was characterized by high intensity on T1-weighted magnetic resonance imaging (MRI), low intensity on T2-weighted MRI, and enhancement on gadolinium MRI. Fluorescein angiography revealed early hypofluorescence and late hyperfluorescence of the tumor and retinal feeder vessels. By April 1996, exudate had developed around the tumor margins. The patient was treated with external beam radiation therapy (20 Gy) in July 1996, but the tumor did not diminish in size. Subsequently, she developed extensive loss of vision due to total ...
CHOROIDAL MELANOMA/RETINAL DETACHMENT (9 year old Australian Shepherd)
CHOROIDAL MELANOMA/RETINAL DETACHMENT (9 year old Australian Shepherd)
NTCP-based prediction of maculopathy after proton therapy or Ruthenium-106 brachytherapy for choroidal melanomas | IOVS | ARVO...
In a secondary analysis, we matched 109 PT pts (treated 2010-2011) to the BT pt cohort, using age, sex, tumor height, and distance from tumor to macula as match factors, and analyzed this selected PT cohort separately. Results : Median follow-up for BT, PT and selected PT cohorts were 7.4 years (interquartile range (IQR): 4.8-9.8), 4.3 years (2.0-8.0), and 3.1 years (2.2-3.7), respectively. Median maximum dose to macula for BT, PT and selected PT cohorts were 19 Gy (IQR: 5-53), 52 Gy (0-52), and 52 Gy (0-52), respectively. The prevalence of maculopathy was 4% for PT and 49% for BT. Maximum dose to macula and maculopathy were significantly correlated in the BT NTCP-model, with odds ratio (OR) for 10 Gy increase in dose 1.9 (95% CI: 1.3-2.8). A similar strong dose-response was not found for PT (OR: 1.1, 1.0-1.2). Neither did the comparable PT model show a significant effect (OR: 1.1, 0.8-1.6). Conclusions : Maculopathy rates were different for PT and BT. The NTCP-model for BT showed a ...
Compare the Results of Iodine-125, Ruthenium-106 and Palladium-103 Plaques » New York Eye Cancer Center
Eye Plaque Results: Treatment of Choroidal Melanoma. In a (2009) publication*, Dr. Finger created a table summarizing the results of the largest major clinical studies of radiation for choroidal melanoma at approximately 5 years follow up.. Chart: Comparison of Results after Plaque Radiation Therapy. (Click to Enlarge and View the Full Chart). ...
Choroidal Melanoma | Cancer Survivors Network
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HealthBoards - View Single Post - choroidal melanoma
A 500-kHz Localized Current Field Hyperthermia System for Use with Ophthalmic Plaque Radiotherapy | Springer for Research &...
Environmental risk factors for uveal melanomas (cancer of the iris, ciliary body and choroid) have not been identified. In order to search for these, we examined the correlation of age-adjusted eye cancer incidence rates, a surrogate for uveal melanoma rates, in U.S. states with group level geographic and demographic factors using multivariate linear regression. Incidence rates for eye cancer were inversely correlated with the percent of the population receiving fluoridated water; i.e., higher rates were found in states with lower prevalences of fluoridation (P = 0.01). Fluoride is known to inhibit the growth of microbial agents that cause choroiditis and choroidal lesions in animals. We speculate that fluoridation protects against choroidal melanoma by inhibiting microbial agents that cause choroiditis and/or choroidal lesions in humans. ...
EURETINA Official | Official EURETINA Website | European Society of Retina Specialists
Magnetic resonante (MRI) showed an apparently choroidal tumour that infiltrated sclera and suggested infiltration of the superior rectus muscle, which would be compatible with a melanoma, which presented differential diagnosis with metastasis or haemangioma. The sonographer reported an elevated hypoechogenic lesion compatible with haemangioma. Fluorescein angiography did not provide us much information, only numerous and marked choroidal folds were evident, with no other alterations of interest in vascularization or parenchyma. Indocyanine green (ICG) did not find alterations to clarify the diagnosis. VA was maintained over the time. Analytical and sistemic imaging tests were normal, so there was no related systemic disease. The size of the lesion was slowly declining ...
Thoughts Concerning Anti-VEGF Treatment for Radiation Retinopathy and Radiation Optic Neuropathy » New York Eye Cancer Center
At The New York Eye Cancer Center we perform presurgical mathematical modeling to compare the intraocular dose distribution of either I-125 or Pd-103 plaque therapy for each patient. For an equivalent tumor dose; we choose the source that will relatively spare the macula, optic nerve, or, if suprathreshold, the lowest organ dose. In comparison to I-125, most patients are better off with the Pd-103 radionuclide.18,20 We do not use Ru-106 plaques for several reasons beyond the scope of this article. Similarly, for our standard EBRT patients, we discuss our concerns with their treating radiation oncologist. We urge a limit of 180 to 200 cGy daily dose rates and the lowest acceptable total doses. We explain that the eye is relatively sensitive to irradiation. In treatment of selected posterior choroidal melanomas that are at high risk for RM or RON, I first offer laser demarcation to suppress the ischemic drive likely contributing to elevated intraocular VEGF.21 Laser delivered in 1 or 2 sessions ...
Retinal astrocytic hamartoma. (a) Juxtapapillary retina | Open-i
Choroidal Nevus | Columbia Ophthalmology
Melanoma is cancer that develops from pigment-producing cells called melanocytes.. Most melanomas develop in the skin, but its also possible for them to occur in other parts of the body, including the eye.. Eye melanoma most commonly affects the eyeball. Doctors sometimes call it uveal or choroidal melanoma, depending on exactly which part of your eye is affected.. It can also affect the conjunctiva (the thin layer that covers the front of the eye) or the eyelid. ...
Search Results for "Visual Acuity" - Ingentium News Magazine
Defining juxtapapillary diverticulum with 3D segmented trueFISP MRCP: comparison with conventional MRCP sequences with an oral...
New hope for children with eye tumors, cancer | EurekAlert! Science News
Papillary tumors of the pineal region
Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 ... These tumors were tested immunohistochemically with a profile similar to that of a choroid plexus tumor; however, ... The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary ... the tumors appeared to be less differentiated than a choroid plexus papilloma and more differentiated than a choroid plexus ...
List of diseases (C)
Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ... syndrome Collins-Sakati syndrome Coloboma chorioretinal cerebellar vermis aplasia Coloboma hair abnormality Coloboma of choroid ... Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ...
List of MeSH codes (C10)
... choroid plexus MeSH C10.228.140.211.500 --- infratentorial neoplasms MeSH C10.228.140.211.500.100 --- brain stem neoplasms MeSH ... choroid plexus MeSH C10.5184.108.40.2060 --- infratentorial neoplasms MeSH C10.5220.127.116.110.200 --- brain stem neoplasms MeSH ... brain neoplasms MeSH C10.228.140.211.280 --- cerebral ventricle neoplasms MeSH C10.228.140.211.280.300 --- choroid plexus ... brain neoplasms MeSH C10.518.104.22.168 --- cerebral ventricle neoplasms MeSH C10.522.214.171.124.200 --- choroid plexus ...
List of MeSH codes (C11)
... iris neoplasms MeSH C11.941.375.385 --- iritis MeSH C11.941.855 --- uveal neoplasms MeSH C11.941.855.198 --- choroid neoplasms ... uveal neoplasms MeSH C11.319.494.198 --- choroid neoplasms MeSH C11.319.494.400 --- iris neoplasms MeSH C11.338.133 --- ... choroid diseases MeSH C11.941.160.177 --- choroid hemorrhage MeSH C11.941.160.238 --- choroid neoplasms MeSH C11.941.160.244 ... eyelid neoplasms MeSH C11.319.457 --- orbital neoplasms MeSH C11.319.475 --- retinal neoplasms MeSH C11.319.475.760 --- ...
List of diseases (P)
Papilloma of choroid plexus Papular mucinosis Papular urticaria Paracoccidioidomycosis Paraganglioma Parainfluenza virus type 3 ... familial Pancreatic diseases Pancreatic islet cell neoplasm Pancreatic islet cell tumors Pancreatic lipomatosis duodenal ... et varioliformis acuta Pityriasis rubra pilaris Piussan-Lenaerts-Mathieu syndrome Placenta disorder Placenta neoplasm Placental ... retardation-hyperkeratosis Parapsoriasis Parasitophobia Parastremmatic dwarfism Parathyroid cancer Parathyroid neoplasm ...
These malignant neoplasms are rare. Choroid plexus translates from the Latin plexus chorioides, which mirrors Ancient Greek ... Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea Young, Paul A. (2007). Basic ... There are four choroid plexuses in the brain, one in each of the ventricles. Choroid plexus is present in all components of the ... There is also choroid plexus in the fourth ventricle, in the section closest to the bottom half of the cerebellum. The choroid ...
Choroid plexus papilloma
Internationally tumors of the choroid plexus are rare, accounting for 0.4-0.6% of all intracranial neoplasms. It most commonly ... Media related to Choroid plexus papilloma at Wikimedia Commons Micrograph of a choroid plexus papilloma. H&E stain. ... Choroid plexus papilloma, also known as papilloma of choroid plexus, is a rare benign neuroepithelial intraventricular WHO ... Choroid plexus papilloma occurs in the lateral ventricles of children and in the fourth ventricle of adults. This is unlike ...
These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma. ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue ...
ICD-10 Chapter II: Neoplasms
Malignant neoplasms of eye and adnexa (C69.0) Conjunctiva (C69.1) Cornea (C69.2) Retina Retinoblastoma (C69.3) Choroid (C69.4) ... Neoplasms. (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and ... Malignant neoplasm of breast (C51) Malignant neoplasm of vulva (C52) Malignant neoplasm of vagina (C53) Malignant neoplasm of ... Malignant neoplasm of penis (C61) Malignant neoplasm of prostate (C62) Malignant neoplasm of testis (C63) Malignant neoplasm of ...
These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma. ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Eye_neoplasm&oldid=895356793" ...
Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus tumor, Dysembryoplastic neuroepithelial tumour, Ependymal ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. Benign brain ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ...
List of diseases (G)
Neoplasm - Melanomas can also be very lightly pigmented, and a lighter colored iris may be a rare manifestation of metastatic ... and angioma of the choroid, often with secondary glaucoma. Simple heterochromia - a rare condition characterized by the absence ... A stimulation of melanin synthesis within iris melanocytes has been postulated.[medical citation needed] Neoplasm - Nevi and ...
Erratum for "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms"". Science. 259 ( ... a proband who is diagnosed with adrenocortical carcinoma or choroid plexus tumour, irrespective of family history ... 1990). "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms". Science. 250 (4985): ... Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". Ann. ...
Endolymphatic sac tumor
Aug 1993). "Papillary neoplasms (Heffner's tumors) of the endolymphatic sac". Ann Otol Rhinol Laryngol. 102 (8 pt 1): 648-51. ... choroid plexus papilloma, middle ear adenocarcinoma, and ceruminous adenoma. Wide excision is the treatment of choice, although ... An endolymphatic sac tumor is a very uncommon papillary epithelial neoplasm arising within the endolymphatic sac or ...
link) Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". ... choroid plexus, colorectal and prostate cancers. 80% of children with adrenocortical carcinoma and 2%-10% of childhood brain ... Erratum for "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms"". Science. 259 ( ... 1990). "Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms". Science. 250 (4985): ...
List of MeSH codes (C04)
... uveal neoplasms MeSH C04.588.364.978.223 --- choroid neoplasms MeSH C04.588.364.978.400 --- iris neoplasms MeSH C04.588.443.353 ... cerebral ventricle neoplasms MeSH C04.588.6126.96.36.199.200 --- choroid plexus neoplasms MeSH C04.588.6188.8.131.52.200.500 ... nose neoplasms MeSH C04.588.149.721.656 --- orbital neoplasms MeSH C04.588.149.721.828 --- skull base neoplasms MeSH C04.588. ... anal gland neoplasms MeSH C04.588.274.476.411.445 --- duodenal neoplasms MeSH C04.588.274.476.411.501 --- ileal neoplasms MeSH ...
List of MeSH codes (C23)
... neoplasm seeding MeSH C23.550.727.650.895 --- neoplasms, unknown primary MeSH C23.550.727.655 --- neoplasm recurrence, local ... choroid hemorrhage MeSH C23.550.414.756.550 --- hyphema MeSH C23.550.414.756.775 --- retinal hemorrhage MeSH C23.550.414.756. ... neoplasm metastasis MeSH C23.550.727.650.560 --- lymphatic metastasis MeSH C23.550.727.650.645 --- neoplasm circulating cells ... MeSH C23.550.727.670 --- neoplasm regression, spontaneous MeSH C23.550.727.700 --- neoplasm, residual MeSH C23.550.737.500 --- ...
Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... Neoplasms will often show as differently colored masses (also referred to as processes) in CT or MRI results. ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ...
... is a cancer (melanoma) of the eye involving the iris, ciliary body, or choroid (collectively referred to as the ... Kumar, Vinay (2009). "Uvea: Neoplasms". Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.). ... Benign melanocytic tumors of the choroid, such as choroidal freckles and nevi, are very common and pose no health risks, unless ...
WHO classification of tumours of the central nervous system
Choroid plexus tumours 1.5.1 Choroid plexus papilloma (ICD-O 9390/0, WHO grade I) 1.5.2 Atypical choroid plexus papilloma ( ICD ... 3.4 Other neoplasms related to the meninges 3.4.1 Haemangioblastoma (ICD-O 9161/1, WHO grade I) 4.1 Malignant Lymphomas (ICD-O ... 9390/1, WHO grade II) 1.5.3 Choroid plexus carcinoma (ICD-O 9390/3, WHO grade III) 1.6. Other neuroepithelial tumours 1.6.1 ...
List of ICD-9 codes 360-389: diseases of the sense organs
ICD-10 Chapter VII: Diseases of the eye, adnexa
Other specified disorders of choroid (H31.9) Disorder of choroid, unspecified (H32) Chorioretinal disorders in diseases ... Neoplasms (C00-D49) Symptoms, signs, and abnormal clinical and laboratory findings, NEC (R00-R94) Syphilis related eye ... Other disorders of choroid (H31.0) Chorioretinal scars (H31.1) Choroidal degeneration (H31.2) Hereditary choroidal dystrophy ...
Primary central nervous system lymphoma
神經母細胞瘤 - 维基百科，自由的百科
Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ... More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, ...
The neoplasms currently referred to as meningiomas were referred to with a wide range of names in older medical literature, ... Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... Even if, by general rule, neoplasms of the nervous system (brain tumors) cannot metastasize into the body because of the blood- ...
ICD-10 Chapter VI: Diseases of the nervous system
International Classification of Diseases for Oncology
NOS M8000/6 Neoplasm, metastatic Neoplasm, metastatic Tumor, metastatic Tumor, secondary Tumor embolus M8000/9 Neoplasm, ... NOS M9390/1 Atypical choroid plexus papilloma M9390/3 Choroid plexus carcinoma Choroid plexus papilloma, anaplastic or ... benign M8000/1 Neoplasm, uncertain whether benign or malignant Neoplasm, NOS Tumor, NOS Unclassified tumor, uncertain whether ... M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67._) Papillary urothelial neoplasm of low malignant ...
Index of oncology articles
... choroid plexus tumor - CHPP - chronic granulocytic leukemia - chronic idiopathic myelofibrosis - chronic leukemia - chronic ... neoplasm - nephrotomogram - nephrotoxic - nephroureterectomy - nerve block - nerve grafting - nerve-sparing radical ... Hürthle cell neoplasm - hydrazine sulfate - hydromorphone - hydronephrosis - hydroureter - hydroxychloroquine - hydroxyurea - ...
Choroidal Melanoma and Lid Fibrofoliculomas in Birt-Hogg-Dubé Syndrome
Pathology of Choroid Plexus Neoplasms: Overview, Etiology, Clinical Features
Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus ... tumors derived from choroid plexus epithelium that are seen predominantly in children. ... Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) ... encoded search term (Pathology of Choroid Plexus Neoplasms) and Pathology of Choroid Plexus Neoplasms ...
Choroid plexus neoplasms - definition of Choroid plexus neoplasms by The Free Dictionary
Choroid plexus neoplasms synonyms, Choroid plexus neoplasms pronunciation, Choroid plexus neoplasms translation, English ... dictionary definition of Choroid plexus neoplasms. n a multilobed vascular membrane, projecting into the cerebral ventricles, ... that secretes cerebrospinal fluid Noun 1. choroid plexus - a vascular plexus of... ... Related to Choroid plexus neoplasms: Choroid Plexus Carcinoma. choroid plexus. n (Anatomy) a multilobed vascular membrane, ...
ICD-9 Code 239.81 -Neoplasms of unspecified nature, retina and choroid- Codify by AAPC
... retina and choroid is a medical classification as listed by WHO under the range - NEOPLASMS OF ... ICD-9 code 239.81 for Neoplasms of unspecified nature, ... Neoplasms of unspecified nature, retina and choroid (239.81). ... ICD-9 code 239.81 for Neoplasms of unspecified nature, retina and choroid is a medical classification as listed by WHO under ... the range -NEOPLASMS OF UNSPECIFIED NATURE (239).. Introducing Codify by AAPC: The Next Level of SuperCoder. SuperCoder will ...
2020 ICD-10-CM Diagnosis Code D31.30: Benign neoplasm of unspecified choroid
Benign neoplasm of unspecified choroid. 2016 2017 2018 2019 2020 Billable/Specific Code *D31.30 is a billable/specific ICD-10- ... Benign neoplasm of eye and adnexa. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Type 1 Excludes*benign neoplasm of ... Malignant neoplasm of ectopic tissue. *Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ... Neoplasms. Note*Functional activity. *All neoplasms are classified in this chapter, whether they are functionally active or not ...
MedPix Case - Choroid Plexus Neoplasm, Papilloma, Carcinoma
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a ... Choroid Neoplasms. Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually ... Ranked list of diseases related to "Choroid Neoplasms"Drugs, active principles and "Choroid Neoplasms"Medicinal plantsQuestions ...
Benign Neoplasm of Choroid | Peterson Health
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ICD-10 Code: C69.3 - Malignant neoplasm of choroid
adult choroid plexus neoplasm 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Cerebral Ventricle Neoplasms / secondary. Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / secondary. Fourth ... MeSH-major] Choroid Plexus Neoplasms / diagnosis. Choroid Plexus Neoplasms / pathology. Meningeal Neoplasms / diagnosis. ... MeSH-major] Choroid Plexus Neoplasms / pathology. Choroid Plexus Neoplasms / physiopathology. Glioma / pathology. Glioma / ... Meningeal Neoplasms / secondary. Neoplasm Seeding. Papilloma, Choroid Plexus / surgery. *[MeSH-minor] Adult. Biomarkers, Tumor ...
Treatment of Tumors of the Choroid Plexus Epithelium - Full Text View - ClinicalTrials.gov
Choroid Plexus Neoplasms. Cerebral Ventricle Neoplasms. Brain Neoplasms. Central Nervous System Neoplasms. Nervous System ... Neoplasms by Site. Neoplasms. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Cyclophosphamide. ... Indication criteria: Atypical choroid plexus papilloma or anaplastic choroid plexus papilloma histology with either metastases ... Treatment of Tumors of the Choroid Plexus Epithelium. The safety and scientific validity of this study is the responsibility of ...
Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma ...
Central Nervous System Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Neoplasms, ... Neoplasms, Germ Cell and Embryonal. Neoplasms, Nerve Tissue. Neoplasms by Site. Nervous System Diseases. Cyclophosphamide. ... childhood choroid plexus tumor. childhood high grade glioma. newly diagnosed childhood ependymoma. ... Choroid plexus carcinoma. *High grade glioma (including anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic ...
Compound Report Card
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Choroid Plexus Neoplasms. D016545. EFO:0007206. choroid plexus cancer. 3. ClinicalTrials. Leukemia, Biphenotypic, Acute. ... Ovarian Neoplasms. D010051. EFO:0003893. ovarian neoplasm. 3. ClinicalTrials. ClinicalTrials. Pancreatic Neoplasms. D010190. ... Nasopharyngeal Neoplasms. D009303. EFO:0004252. nasopharyngeal neoplasm. 2. ClinicalTrials. Neoplasms. D009369. EFO:0000311. ... Urethral Neoplasms. D014523. EFO:0003846. urethral neoplasm. 3. ClinicalTrials. ClinicalTrials. Uterine Cervical Neoplasms. ...
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Magnetic resonance imaging characteristics of posterior scleritis mimicking choroidal mass
Draft ICD-10-CM/PCS MS-DRGv28 Definitions Manual
Neoplasm of unspecified behavior of retina and choroid. D4989. Neoplasm of unspecified behavior of other specified sites. ... Personal history of malignant neoplasm of tongue. Z85818. Personal history of malignant neoplasm of other sites of lip, oral ... Personal history of malignant neoplasm of cervix uteri. Z8542. Personal history of malignant neoplasm of other parts of uterus ... Personal history of malignant neoplasm of larynx. Z8522. Personal history of malignant neoplasm of nasal cavities, middle ear, ...
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SNRPE Gene - GeneCards | RUXE Protein | RUXE Antibody
Efficacy and Safety Study of Lomustine/Temozolomide Combination Therapy vs. Standard Therapy for Glioblastoma Patients
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A Boy With Worsening Esotropia - American Academy of Ophthalmology
2 Fuller C. Pathology of Choroid Plexus Neoplasms. Medscape. http://emedicine.medscape.com/article/1744050-overview#a1. ... as opposed to choroid plexus carcinomas (WHO grade III), which are malignant.2 Choroid plexus papillomas cause the choroid ... Choroid plexus papillomas develop from the ventricular choroid plexus, which produces the cerebrospinal fluid (CSF) in the ... A choroid plexus papilloma is usually treated with a total mass resection.2 These resections have a high success rate even in ...
GENE.00023 Gene Expression Profiling of Melanomas
Most uveal tract melanomas originate in the choroid. The ciliary body is less commonly a site of origin, and the iris is the ... in newer prognostic molecular techniques such as gene expression profiling to differentiate benign from malignant neoplasms, or ... According to the National Cancer Institute (NCI, 2015), melanoma of the uveal tract (iris, ciliary body, and choroid) is the ...
Left ventricular metastasis from ocular melanoma: a new, rare, and unusual pathway?
Melanoma is a neoplasm known for its propensity for cardiac involvement. When there exists an isolated metastasis to the heart ... Choroid Neoplasms / pathology*, surgery. Eye Enucleation. Follow-Up Studies. Heart Neoplasms / diagnosis, secondary*, surgery. ... Melanoma is a neoplasm known for its propensity for cardiac involvement. When there exists an isolated metastasis to the heart ...
DRUG.00046 Ipilimumab (Yervoy®)
Choroid plexus - Wikipedia
These malignant neoplasms are rare. Choroid plexus translates from the Latin plexus chorioides, which mirrors Ancient Greek ... Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea Young, Paul A. (2007). Basic ... There are four choroid plexuses in the brain, one in each of the ventricles. Choroid plexus is present in all components of the ... There is also choroid plexus in the fourth ventricle, in the section closest to the bottom half of the cerebellum. The choroid ...
c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism | SpringerLink
Choroid plexus tumours (CPTs) account for 2-5% of brain tumours in children. They can spread along the neuraxis and can recur ... Choroid plexus tumours (CPT) are intracranial neoplasms derived from the choroid plexus epithelium. They predominantly occur in ... choroid plexus; CPT-choroid plexus tumour; ACPP - atypical choroid plexus tumour; CPP - choroid plexus papilloma; NSPCs - ... We show here that c-MYC overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus ...
PapillomaCarcinomaTumorCarcinomasRetinaMelanomaIntracranial neoplasmsEpendymomaEpitheliumCiliaryDiagnosisPediatricMetastasisHyperplasia of the choroid plexusPatients with choroid plexus tumorsMeningiomaThird ventricleNeuroendocrineCPPsRare tumorsResected choroid plexus tumorsAdultChoroidalEpithelialHydrocephalusCentral nervous sTumors are rareHistologyCommon intraventricularAbstractCases of choroidIntraventricular neoplasmsLateral ventriclesMethylationIntraocular tumors
- Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
- This coronal T1-weighted magnetic resonance image (MRI) following contrast administration shows a homogeneously enhancing choroid plexus papilloma within the right lateral ventricle of a 1-year-old boy. (medscape.com)
- Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea Young, Paul A. (2007). (wikipedia.org)
- There are three histopathological classifications of choroid plexus tumors: choroid plexus papilloma (CPP), atypical choroid plexus papilloma (ACP), and choroid plexus carcinoma (CPC). (springer.com)
- Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature. (springer.com)
- Choroid plexus papilloma in a girl with hypomelanosis of Ito. (springer.com)
- Suprasellar seeding of a benign choroid plexus papilloma of the fourth ventricle with local recurrence. (springer.com)
- Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. (springer.com)
- A choroid plexus papilloma is usually treated with a total mass resection. (aao.org)
- PTPR have morphological features in common with a number of other papillary-like tumors that occur in the pineal region, including pineal parenchymal neoplasms, choroid plexus papilloma, papillary ependymoma, metastatic papillary carcinomas, papillary meningioma and germ cell tumors ( 5 , 7 ), which complicates the clinical diagnosis of PTPR. (spandidos-publications.com)
- 53 Choroid plexus papilloma (CPP) ia a non-cancerous (benign) tumor of the choroid plexus, a network of blood vessels in the brain which surrounds the ventricles and produces the fluid surrounding the brain and spinal cord (cerebrospinal fluid, or CSF). (malacards.org)
- Papilloma of Choroid Plexus, also known as choroid plexus papilloma , is related to choroid plexus cancer and atypical choroid plexus papilloma , and has symptoms including seizures , vomiting and headache . (malacards.org)
- An important gene associated with Papilloma of Choroid Plexus is TP53 (Tumor Protein P53), and among its related pathways/superpathways are MAPK signaling pathway and Cell cycle . (malacards.org)
- 75 Papilloma of choroid plexus: A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. (malacards.org)
- The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
- Glial fibrillary acidic protein (GFAP) may be positive in up to 20% of cases of choroid plexus papilloma. (statpearls.com)
- Genetic analyses have reported germline mutations in the TP53 gene in some patients with choroid plexus papilloma. (statpearls.com)
- Syndromic associations of choroid plexus papilloma include Aicardi syndrome, hypomelanosis of Ito, and 9p duplication. (statpearls.com)
- Pineal region choroid plexus papilloma treated with stereotactic radiosurgery: a case study. (naver.com)
- Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series. (naver.com)
- Choroid plexus papilloma (CPP) are the most common tumor arising in the trigone of the lateral ventricle in children. (uab.edu)
- Gross total resection improves overall survival in children with choroid plexus carcinoma. (springer.com)
- Eppinger MA, Berman CM, Halpern SL, Mazzola CA (2016) Prolonged Survival for Choroid Plexus Carcinoma with Oncocytic Changes: A Case Report. (omicsonline.org)
- Introduction: Choroid plexus carcinoma (CPC) is a rare central nervous system neoplasm derived from the choroid plexus epithelium. (omicsonline.org)
- Choroid plexus carcinoma s ( CPC ) are rare, malignant neoplasms that represent 20-30% of CPTs in children [ 5 ]. (omicsonline.org)
- Pathological and immunohistochemical studies of choroid plexus carcinoma of the dog. (thefreedictionary.com)
- 3. Patients who have a past or current history of neoplasm other than the entry diagnosis, except for curatively treated non-melanoma skin cancer or carcinoma in situ of the cervix or other cancers treated for cure and with a disease-free survival longer than 5 years. (knowcancer.com)
- The exemptions are primary brain tumors, among which the typical intracranial teratoma was not diagnosed, whereas 2 cases of rarely encountered neoplasms were reported: craniopharyngioma and choroid plexus carcinoma. (medscimonit.com)
- Upendra M. Chowdhary ,Diethelm H. Boehme ,Ali A. Satir , Light microscopic and ultrastructural study of choroid plexus carcinoma, Saudi Med. (who.int)
- Choroid plexus carcinoma or choroid plexus tumor is a type of cancerous tumor that occurs in the brain's choroid plexus tissue and most often occurs in children. (diseaseinfosearch.org)
- Symptoms of choroid plexus carcinoma are similar to those of other brain tumors including frequent headaches, unusually large head due to excess fluid on the brain, or large "soft spots" found on the baby's head. (diseaseinfosearch.org)
- If your baby has been diagnosed with a choroid plexus carcinoma, talk to your baby's doctor and specialists about the most current treatment options. (diseaseinfosearch.org)
- Following organizations serve the condition "Choroid plexus carcinoma" for support, advocacy or research. (diseaseinfosearch.org)
- Finding the right clinical trial for Choroid plexus carcinoma can be challenging. (diseaseinfosearch.org)
- The terms "Choroid plexus carcinoma" returned 27 free, full-text research articles on human participants. (diseaseinfosearch.org)
- Choroid plexus carcinoma with hyaline globules: An unusual histological feature. (diseaseinfosearch.org)
- Choroid plexus carcinoma in adults: an extremely rare case. (diseaseinfosearch.org)
- Imaging findings are not reliable for distinguishing between CPP and choroid plexus carcinoma, which represent about 10% of choroid plexus neoplasms. (uab.edu)
- For example, CNS atypical teratoid/rhabdoid tumor is often misclassified as medulloblastoma, primitive neuroectodermal tumor, or choroid plexus carcinoma ( 1 ). (aacrjournals.org)
- Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
- The most frequent route of choroid plexus tumor spread is via seeding of the CSF. (medscape.com)
- To improve choroid plexus tumor treatment through better understanding of the tumor biology and through increased knowledge about the benefit of specific treatment elements. (clinicaltrials.gov)
- To compare the survival times after cyclophosphamide based treatment with the survival times after carboplatin based treatment in choroid plexus tumor patients. (clinicaltrials.gov)
- There are three graded types of choroid plexus tumor that mainly affect young children. (wikipedia.org)
- Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. (springer.com)
- Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). (wikipedia.org)
- Choroid Cancer, also known as malignant tumor of the choroid , is related to melanoma, uveal and pulmonary aspergilloma . (malacards.org)
- However, the frozen section indicated a choroid plexus tumor, which has a significantly better prognosis. (aao.org)
- see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. (thefreedictionary.com)
- Brain Tumor News: Second neoplasms in pediatric patients with primary central nervous system tumors: the St. Jude Children`s Research Hospital experience. (virtualtrials.com)
- Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization (WHO) "Classification of Tumors of the Nervous System. (wikipedia.org)
- Binding of the large T antigen with both p53 and pRb tumor suppressor proteins, forming complexes, has been demonstrated in humans harboring choroid plexus tumors. (statpearls.com)
- Choroid plexus tumors (CPTs) are of epithelial origin, and the most important prognostic factor in human medicine is the tumor grade. (elsevier.com)
- Rather, membranous expression of both molecules was increased in CPTs compared to normal choroid plexus (NCP), regardless of tumor grade. (elsevier.com)
- Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
- Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
- Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
- Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
- Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
- According to cellular differentiation, number of mitosis and local invasion, choroid plexus neoplasms can be classified as choroid plexus papillomas or carcinomas (KOESTNER et al. (thefreedictionary.com)
- Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. (springer.com)
- The World Health Organization (WHO) classifies choroid plexus tumors as ranging from more benign papillomas, referred to as WHO Grade I, to carcinomas, referred to as WHO Grade III. (aao.org)
- 2 Excluding rare cases, choroid plexus papillomas of WHO grade I and II are almost always benign, as opposed to choroid plexus carcinomas (WHO grade III), which are malignant. (aao.org)
- Typical choroid plexus carcinomas (CPCs) show variable morphology with a syncytial or solid arrangement. (thefreedictionary.com)
- 57 Choroid plexus tumors are of neuroectodermal origin and range from benign choroid plexus papillomas (CPPs) to malignant choroid carcinomas (CPCs). (malacards.org)
- A total of 39 consecutive patients with pathologically proven CPTs (31 choroid plexus papillomas [CPPs] and 8 choroid plexus carcinomas [CPCs]) were included in this series. (thejns.org)
- The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. (uzh.ch)
- According to the 2016 World Health Organization classification, choroid plexus tumors are classified as papillomas (grade I), atypical tumors (grade II) and carcinomas (grade III). (statpearls.com)
- Choroid plexus papillomas have less than two mitotic figures per 10 high power fields, atypical ones have two to five per 10 high power fields, and carcinomas have greater than five mitotic figures per 10 high power fields. (statpearls.com)
- CONCLUSIONS: In TySV40 transgenic mice, intraocular tumors develop that arise at the choroid-RPE interface, and they display morphologic and ultrastructural features consistent with RPE carcinomas. (arvojournals.org)
- Which therapy works better in choroid plexus carcinomas? (elsevier.com)
- Choroid plexus carcinomas (CPCs) are rare tumors with dismal outcome. (elsevier.com)
- Choroid plexus carcinomas in childhood: clinical features and prognostic factors. (naver.com)
- Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which are difficult to distinguish with conventional imaging. (diseaseinfosearch.org)
- In the current study, 42 canine CPTs (19 choroid plexus papillomas and 23 choroid plexus carcinomas) were retrospectively reviewed, and the intensity and cellular staining pattern of E-cadherin and β-catenin were correlated with histological features, paying special attention to grade, invasion, and metastasis. (elsevier.com)
- ICD-9 code 239.81 for Neoplasms of unspecified nature, retina and choroid is a medical classification as listed by WHO under the range -NEOPLASMS OF UNSPECIFIED NATURE (239). (aapc.com)
- Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) Iridocyclectomy - Removal of the iris plus the ciliary body muscle. (wikipedia.org)
- Benign tumors of the lid, conjunctiva, iris, and choroid are common, whereas those of the retina and cornea are rare. (nih.gov)
- Although the fluid usually resorbs and leakage stops within days to weeks, it has been suggested that photocoagulation itself somehow weakens the layer between the retina and choroid (Bruch membrane) and in some way may stimulate transformation to malignancy. (nih.gov)
- Other flat lesions in the choroid that have been confused with nevi and melanoma include hyperplasia of the retinal pigment epithelium, hamartomas of the retinal pigment epithelium, and hemorrhages within the retina, especially hemorrhages beneath the retinal pigment epithelium (as part of macular degeneration). (nih.gov)
- Melanoma is a neoplasm known for its propensity for cardiac involvement. (biomedsearch.com)
- 2. Patients whose site of primary melanoma is not in the choroid(eye). (knowcancer.com)
- The choroid layer is the most likely site of melanoma in the eye. (medlineplus.gov)
- Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. (curehunter.com)
- The study found that the pigmented neoplasms were ranked in the first place of ciliary body tumors, in which melanoma of ciliary body were majority. (arvojournals.org)
- Symptomatic impairment of urine transport after malignant melanoma of the choroid]. (nih.gov)
- [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
- Choroid plexus tumours (CPT) are intracranial neoplasms derived from the choroid plexus epithelium. (springer.com)
- Choroid plexus tumors (CPTs) are rare intracranial neoplasms that constitute approximately 2%-5% of all pediatric brain tumors. (thejns.org)
- Schwannomas account for up to 8% of intracranial neoplasms (14). (upmc.edu)
- In the pediatric population, they form the third most common congenital brain tumors, after teratomas and gliomas, and account for 0.4 to 0.6% of all intracranial neoplasms. (statpearls.com)
- As a group, gliomas are the most common primary central nervous system (CNS) neoplasms in both adult and pediatric populations, whereas infiltrative gliomas, in particular glioblastoma, make up the bulk of adult glial tumors, pilocytic astrocytoma, and ependymoma predominate in children. (hindawi.com)
- Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
- It should be pointed out, however, that TTR is not entirely specific for choroid plexus neoplasms , since TTR immunoreactivity has been documented in several other neoplasms, retinal pigment epithelium, and hepatocytes. (thefreedictionary.com)
- The epithelium of the choroid plexus is continuous with the ependymal cell layer that lines the ventricles, but unlike the ependyma, the epithelial layer has tight junctions between the cells on the side facing the ventricle (apical surface). (wikipedia.org)
- We show here that c-MYC overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. (springer.com)
- WDPs have a consistent ocular phenotype of photophobia, hypopigmented adnexal structures, blue irides with a tan periphery and hypopigmented retinal pigment epithelium and choroid. (jove.com)
- PURPOSE: To characterize intraocular tumors that arise by in situ transformation in the choroid-retinal pigment epithelium (RPE) in transgenic mice bearing the SV40 oncogene under the control of the mouse tyrosinase promoter. (arvojournals.org)
- Choroid plexus tumors are rare intraventricular papillary neoplasms derived from choroid plexus epithelium, which account for approximately 2% to 4% of intracranial tumors in children and 0.5% in adults. (diseaseinfosearch.org)
- These tumors can occur in the choroid, iris and ciliary body. (wikipedia.org)
- Even less common are melanocytomas originating in the choroid, ciliary body, or iris. (nih.gov)
- By analyzing the histogenesis and classification, histopathologic characteristics, clinical feature and the key point of differential diagnosis of ciliary body neoplasms, the study provided the basis for clinical diagnosis and treatment. (arvojournals.org)
- Eighty-three specimens of ciliary body neoplasms on file (1959∼2005) were analyzed and studied for the characteristics of location, histogenesis, clinical presentation and histopathology. (arvojournals.org)
- 18 cases were melanocytoma, occupied 21.7% of the ciliary body neoplasms and 42.9% of the pigmented tumors. (arvojournals.org)
- By further recognizing the clinical features and histopathologic characteristics of ciliary body neoplasms, it may help clinical ophthalmologists to make correct diagnosis and proper treatment. (arvojournals.org)
- Although BFH of the choroid is very rare, its benign nature and the availability of choroidal biopsy for tissue diagnosis make it important to include this as one of the differential diagnoses for amelanotic choroidal mass. (elsevier.com)
- The radiologic finding of erosion of the skull base by this mass lesion may have contributed to its interpretation as a destructive neoplasm, with the differential diagnosis including chondrosarcoma, metastatic lesion, osteosarcoma, and meningioma. (thefreelibrary.com)
- However, the histology in this case ruled out a diagnosis of neoplasm. (thefreelibrary.com)
- The authors present the case of a child with partial trisomy 9p and delayed diagnosis of hydrocephalus with radiographic evidence of DVHCP who was successfully managed with ventriculoperitoneal shunt (VPS) placement, adjuvant bilateral endoscopic choroid plexus coagulation (CPC), and the novel application of anterior choroidal artery embolization. (thejns.org)
- The histological diagnosis was that of choroid. (who.int)
- In the pediatric population, the most common intradural extramedullary neoplasms are leptomeningeal metastases resulting from primary brain tumors whereas in adults non-CNS tumors are most commonly encountered. (radiopaedia.org)
- Radiologic-pathologic correlation of pediatric and adolescent spinal neoplasms: Part 2, Intradural extramedullary spinal neoplasms. (radiopaedia.org)
- BACKGROUND: Details on second neoplasms (SNs) following pediatric central nervous system (CNS) tumors are scant, because of the rarity of such SNs. (virtualtrials.com)
- Background: Congenital tumors form a unique group among pediatric neoplasms. (medscimonit.com)
- Pediatric choroid plexus neoplasms. (naver.com)
- The TySV40 transgenic murine tumors represent potentially useful tools for investigations into the biology and metastasis of intraocular neoplasms. (arvojournals.org)
- Although detailed systemic examinations were performed, no metastasis to lymph nodes or distant organs except the choroid plexus was detected, which is very rare in a case of stage IV primary lung cancer. (elsevier.com)
Hyperplasia of the choroid plexus2
Patients with choroid plexus tumors2
Resected choroid plexus tumors1
- Clinical outcome of adult choroid plexus tumors: retrospective analysis of a single institute. (springer.com)
- The human IGF-II gene is maternally imprinted in all tissues except adult liver and the choroid plexus/leptomeninges of the central nervous system where IGF-II is biallelically expressed. (elsevier.com)
- The choroid plexus consists of many capillaries, separated from the ventricles by choroid epithelial cells. (wikipedia.org)
- it is composed of epithelial cells of the choroid plexus at the peripheral blood-CSF boundary and the arachnoid membrane at the cerebral blood-CSF boundary. (wikipedia.org)
- Choroid plexus tumors (CPTs) are rare, intraventricular neoplasms that originate from the epithelial cells of the choroid plexus [ 1 - 4 ]. (omicsonline.org)
- MIB-1 immunoreactivity reveals different labelling in low-grade and in malignant epithelial neoplasms of the choroid plexus. (uzh.ch)
Central nervous s2
- Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). (bioportfolio.com)
- The new WHO classification introduces 7 changes in the grading of central nervous system neoplasms, ranging in significance from minor to major, in categories of anaplastic oligoastrocytomas, meningiomas, choroid plexus tumors, pineal parenchymal tumors, ganglioglioma, cerebellar liponeurocytoma, and hemangiopericytomas. (elsevier.com)
Tumors are rare1
- abstract = "Intracranial xanthogranulomas are rare benign tumors and occur most commonly as choroid plexus xanthogranulomas, which rarely become symptomatic. (elsevier.com)
- abstract = "A 20-month-old infant found to have a blind eye with neovascular glaucoma was thought to have a neoplasm of the optic nerve for which enucleation was performed with resection of a long segment of optic nerve. (elsevier.com)
Cases of choroid1
- Choroid plexus is present in all components of the ventricular system except for the cerebral aqueduct, the frontal horn and the occipital horn of the lateral ventricles. (wikipedia.org)
- Choroid plexus papillomas (CPP) are very rare and are commonly found in the lateral ventricles (LV) in children. (minervamedica.it)