A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)
A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)
Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)
A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.
The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.
The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.
A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.
Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
A pathological process consisting of the formation of new blood vessels in the CHOROID.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.
Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.
The blood vessels which supply and drain the RETINA.
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.
Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), that can cause chronic pneumonia (maedi), mastitis, arthritis, and encephalomyelitis (visna) in sheep. Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). Visna is a demyelinating leukoencephalomyelitis of sheep which is similar to but not the same as SCRAPIE.
A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
A tissue preparation technique that involves the injecting of plastic (acrylates) into blood vessels or other hollow viscera and treating the tissue with a caustic substance. This results in a negative copy or a solid replica of the enclosed space of the tissue that is ready for viewing under a scanning electron microscope.
A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Value of all final goods and services produced in a country in one year.

Microvascular loops and networks as prognostic indicators in choroidal and ciliary body melanomas. (1/1300)

BACKGROUND: Malignant melanoma of the ciliary body and choroid of the eye is a tumor that disseminates frequently, and 50% of the diagnosed patients die within 10 years. We investigated the hypothesis that, by histopathologic analysis of the arrangement of microvessels (i.e., small blood vessels) in loops and networks, we might be able to differentiate better those patients with a favorable prognosis from those with a poor prognosis. METHODS: We conducted a population-based, retrospective cohort study of melanoma-specific and all-cause mortality for 167 consecutive patients who had an eye surgically removed because of malignant choroidal or ciliary body melanoma during the period from 1972 through 1981. Microvascular loops and networks were evaluated independently by two pathologists who were unaware of patient outcome. RESULTS: Microvascular patterns could be assessed in 134 (80%) of 167 melanoma specimens. The 10-year probability of melanoma-specific survival was worse if microvascular loops (0.45 versus 0.83; two-sided P<.0001) and networks (0.41 versus 0.72, two-sided P<.0001) were present. In multivariate Cox regression analysis of melanoma-specific survival, the hazard ratios were 1.66 (95% confidence interval [CI] = 1.19-2.30) for the presence of loops and networks as a combined three-category variable, 2.36 (95% CI = 1.37-4.05) for the presence of epithelioid cells, 1.11 (95% CI = 1.03-1.19) for the largest basal tumor diameter (evaluated as a continuous variable), and 2.14 (95% CI = 1.25-3.67) for ciliary body involvement. CONCLUSIONS: Patients with malignant uveal melanoma who have a favorable prognosis can be distinguished from those with a poor prognosis by histopathologic analysis of microvascular patterns in uveal melanoma tumor specimens.  (+info)

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. (2/1300)

PURPOSE: To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes and choroid in vivo. METHODS: Human Bruch's membrane samples were isolated from the retinal pigment epithelium (RPE) and choroid and subjected to reversed-phase high-performance liquid chromatography to determine pentosidine content. A polyclonal anti-pentosidine antibody and a monoclonal antibody specific for carboxymethyllysine were used to localize AGEs in 20-month-old nondiabetic, 82-year-old nondiabetic, and 82-year-old diabetic globes. RESULTS: Human Bruch's membranes (n = 20) showed a linear age-dependent increase in pentosidine that reached approximately 0.17 millimoles pentosidine per mole hydroxyproline in late life (r = 0.896; P < 0.001). Immunohistochemical evaluation showed evidence of pentosidine in Bruch's membrane, choroidal extracellular matrix, and vessel walls in the 82-year-old nondiabetic and diabetic globes. A similar staining pattern was found with the anti-CML antibody. Basal laminar deposits and drusen stained with both antibodies in the elderly nondiabetic eye. In contrast, neither antibody stained the 20-month-old tissue. CONCLUSIONS: We provide biochemical and immunohistochemical evidence for the formation of pentosidine and CML structures in human Bruch's membrane and choroid with age. These changes could promote aging of the RPE-Bruch's membrane-choroid complex.  (+info)

Idiopathic central serous chorioretinopathy. (3/1300)

Idiopathic central serous chorioretinopathy (ICSC) is usually seen in young males with Type A personality. Clinical evaluation of the macula with fundoscopy and biomicroscopy, coupled with fluorescein angiography establishes the diagnosis. Indocyanine green angiographic studies have reinformed that the basic pathology lies in choriocapillaries and retinal pigment epithelium. Most of the ICSC resolve completely in four months, and some of them could resolve early with direct photocoagulation of the leaking site. Oral steroids have no role, and could even cause an adverse reaction.  (+info)

Clinical characteristics of CHARGE syndrome. (4/1300)

CHARGE syndrome, first described by Pagon, was named for its six major clinical features. They are: coloboma of the eye, heart defects, atresia of the choanae, retarded growth and development including CNS anomalies, genital hypoplasia and/or urinary tract anomalies, and ear anomalies and/or hearing loss. We experienced three cases of CHARGE syndrome who displayed ocular coloboma, heart defects, retarded growth and development, and external ear anomalies, and we also review the previously reported literature concerning CHARGE syndrome.  (+info)

Effects of bicarbonate ion on chick retinal pigment epithelium: membrane potentials and light-evoked responses. (5/1300)

The purpose of this study was to determine how changes in [HCO3-] alter the electrical properties of the retinal pigment epithelium (RPE). Experiments were conducted on the isolated chick retina-RPE-choroid preparation. The chamber holding the preparation allowed independent perfusion of the retinal and the choroidal surfaces. The light-evoked trans-tissue potential (TTP), the trans-epithelial potential (TEP), the trans-retinal potentials, and the intracellularly-recorded apical and basal membrane potentials were studied. Increasing the [HCO3-]0 in the choroidal bath from 25 to 40 mEq/1 led to an increase in the TTP and TEP. The same change in the retinal bath decreased the TTP because of a biphasic change of the RPE membrane potentials. There was also an increase in the amplitudes of the TEP, the c-wave and the slow PIII. The light-evoked subretinal K+ decrease was greater which is consistent with an increase in the photoreceptor light response. These observations indicated that the decrease of TTP resulted from a basal membrane hyperpolarization followed by an apical membrane depolarization induced by an increase in retinal [HCO3-]0. The relationship of these potential changes to the human bicarbonate responses is discussed.  (+info)

Dendritic cells and macrophages in the uveal tract of the normal mouse eye. (6/1300)

BACKGROUND/AIMS: Dendritic cells (DC) and macrophages are components of the immune cell populations in the uveal tract whose density, distribution, turnover, and function may play a role in the maintenance of immunological homeostasis in the eye. Little is known of these cells in the mouse eye despite this being the predominant experimental model in many studies of ocular immune responses and immunoinflammatory mediated eye diseases. The aim of the present study was to obtain further immunophenotypic data on resident tissue macrophages and DC populations in the mouse uveal tract. METHODS: Pieces of iris, ciliary body, and choroid dissected from perfusion fixed BALB/c mice were incubated whole in a variety of anti-macrophage and DC monoclonal antibodies (mAbs). Labelled cells were visualised using either single or double immunoperoxidase techniques. RESULTS: Quantitative analysis and double immunolabelling revealed that 80% of F4/80(+) cells (a mAb that recognises both DC and macrophages) in the iris are macrophages (SER4(+)). The iris contained a network of Ia+ cells (412 (SD 130) cells/mm2) of which two thirds appear to be DC. A similar pattern was observed in the ciliary body and choroid. Only a few DC in the uveal tract were very weakly reactive for mAbs which recognise B7-1 (CD80), B7-2 (CD86), beta2 integrin (mAb N418), and multivesicular bodies associated with antigen presentation (mAb M342). CONCLUSIONS: The present study reveals that the mouse uveal tract, like the rat, contains rich networks of DC and resident tissue macrophages. The networks of resident tissue macrophages in the mouse uveal tract closely resemble similar networks in non-ocular tissues. The phenotype of uveal tract DC suggests they are in the "immature" phase of their life cycle, similar to Langerhans cells of the skin, thus implying their role in situ within the eye is antigen capture and not antigen presentation.  (+info)

Zinc deficiency and oxidative stress in the retina of pigmented rats. (7/1300)

PURPOSE: To determine the effect of moderate zinc deficiency on antioxidant defenses and measures of oxidative stress in the retina and retinal pigment epithelium (RPE) of Brown Norway Rats. METHODS: Twenty-four rats were housed individually and divided into three groups of 8 rats each. Group 1 was fed ad libitum a semipurified control diet formulated to contain 50 parts per million [ppm] total zinc; group 2 was fed ad libitum an identical diet but containing 5 ppm total zinc; and group 3 was pair-fed the control diet but restricted in amount to that consumed by group 2. Food intake was measured daily and the rats weighed weekly. After 6 weeks, the rats were killed and the following measurements were made: serum zinc, serum alkaline phosphatase, retinal zinc, RPE-choroid zinc, RPE-choroid catalase, liver metallothionein (MT), retinal MT, RPE-choroid MT, retinal catalase, and retinal thiobarbituric reactive substances (TBARS). RESULTS: The following showed statistically significant differences between groups 2 and 3, respectively: serum Zn (1216 micro/l versus 1555 microg/l, P < or = 0.01), serum alkaline phosphatase (3.75 U/mg versus 5.10 U/mg, P < or = 0.05), liver MT (4.3 microg/mg protein versus 16.7 microg/mg, P < or = 0.0001), RPE-choroid MT (1.3 microg/mg protein versus 2.2 microg/mg, P < or = 0.02), retinal MT (0.85 microg/mg protein versus 2.8 microg/mg, P < or = 0.05), and retinal TBARS (6.2 nM/mg protein versus 2.2 nM/mg, P < or = 0.05). CONCLUSIONS: The results show that retinal MT and RPE MT concentrations are very sensitive to intake of dietary zinc. The increase in retinal TBARS in group 2 indicates that moderate zinc deficiency increases oxidative stress to the retina. The results also suggest that MT is protective against lipid peroxidation of retinal membranes.  (+info)

Structural specializations of the eye in the vizcacha (Lagostomus maximus maximus). (8/1300)

Vizcachas (Lagostomus maximus maximus, Chinchillidae) are nocturnal rodents living in burrows in many regions of Argentina, Bolivia, and Chile. We have studied the eye of the vizcacha using several light and electron microscopic procedures, with the purpose of understanding the role of vision in the behavior of this species. Our observations demonstrated an avascular, rod-rich retina, with a specialized region spanning through most of the equator of the eye. In this central band, all neural retinal layers exhibited a high cell density, whereas the photoreceptor layer was characterized by the presence of very long rods. In addition, the central region was associated with a distinct pigmentation pattern, including scarce granulation of the pigment epithelium, low pigmentation of the choroid, and the selective attachment of suprachoroidal cells to the inner scleral surface. These central modifications probably form the structural basis of a reflecting tapetum. The eye of the vizcacha received both long and short ciliary vessels, and a specialized cilio-sclero-choroidal vascular network appeared at the equatorial region. Our findings suggest that the equatorial region of the eye of the vizcacha could be a highly sensitive light detector related to foraging behaviors during crepuscular or nocturnal hours.  (+info)

A total of 56 eyes had choroidal vascular hyperpermeability, of which 49 eyes (87.5%) had enhanced-depth imaging OCT images available. Mean subfoveal choroidal thickness was 389.5 ± 121.1 μm in these 49 eyes. Subfoveal choroidal thickness was less than 200 μm in four eyes (one eye with typical exudative AMD, three eyes with PCV), between 200 and 400 μm in 21 eyes (4 eyes with typical exudative AMD, 17 eyes with PCVs), and greater than 400 μm in 24 eyes (4 eyes with typical exudative AMD, 20 eyes with PCVs, Fig. 2A). Of the 168 eyes with punctate hyperfluorescent spots, enhanced-depth imaging OCT images were available in 154 eyes (91.7%). Mean subfoveal choroidal thickness was 318.6 ± 127.4 μm in these 154 eyes. Subfoveal choroidal thickness was less than 200 μm in 30 eyes (10 eyes with typical exudative AMD, 16 eyes with PCV, 3 eyes with RAP, 1 eye with myopic CNV), between 200 and 400 μm in 79 eyes (16 eyes with typical exudative AMD, 59 eyes with PCV, 1 eye with RAP, 3 eyes with ...
The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregnant women using spectral-domain optical coherence tomography (OCT). This cross-sectional study included 122 eyes of 61 women, divided into two groups: 27 healthy pregnant women in the third trimester and 34 age-matched healthy non-pregnant women. Choroidal thickness was measured using Enhanced Depth Imaging OCT at ten different locations: at the fovea and every 500 µm from the fovea up to 2500 µm temporally and up to 2000 µm nasally. There were no significant differences in the ten measurements of choroidal thickness comparing both groups. Mean subfoveal choroidal thickness was 304.1 + 9.6 µm in the control group and 318.1 + 15.6 µm in the pregnant women group (p = 0.446). There was also no statistically significant association between gestational age and choroidal thickness measurements in the
Mean follow-up was 1.6 ± 0.76 years, without difference between the two study groups (p=0.6766). Choroid was significantly thicker in the bilateral GA group eyes compared to the fellow eye CNV group eyes at baseline (mean choroidal thickness: 170.5 ± 78.5 μm vs 129.1 ± 36.1 μm, p = 0.0371 ) and during follow-up (mean choroidal thickness: 173.2 ± 86.1 μm vs 123 ± 32.1 μm, p = 0.0340) . Mean choroidal thickness significantly decreased during follow-up only in the fellow eye CNV group (p=0.0276 in the fellow eye CNV group vs p= 0.4137 in the bilateral GA group). Mean GA area was not significantly different in the two groups neither at baseline nor at follow-up (p=0.4118 in B-FAF and p= 0.6806 in NIR-FAF at baseline, p= 0.5734 in B-FAF and p=0.8945 in NIR-FAF at follow-up) even if mean GA area significantly increased in both groups during follow-up. Mean retinal sensitivity significantly decreased during follow-up only in the bilateral GA group (p= 0.0405 in the bilateral GA group vs ...
Results The mean choroidal thickness at the fovea prior to smoking was 301.1±63.1 μm, which decreased to 284.2±56.7 μm at 1 h and 270.8±80.0 μm at 3 h following smoking (p=0.001). The mean choroidal thickness was significantly decreased following smoking at all five extrafoveal points. The difference in choroidal thickness was not statistically significant at 1 and 3 h of smoking at all six points. In the control group, the mean baseline choroidal thickness at the fovea was 270.6±57.9 μm, which was 272.5±52.4 μm at 1 h and 273.8±57.4 μm at 3 h (p=0.816).. ...
TY - JOUR. T1 - Discrepancy in Subfoveal Choroidal Thickness in Healthy Adults with Isometropia. AU - Kang, Hae M.. AU - Kim, Suk J.. AU - Koh, Hyoung J.. AU - Lee, Christopher S.. AU - Lee, Sung C.. PY - 2015/11. Y1 - 2015/11. UR - http://www.scopus.com/inward/record.url?scp=84930817420&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84930817420&partnerID=8YFLogxK. U2 - 10.1016/j.ophtha.2015.05.015. DO - 10.1016/j.ophtha.2015.05.015. M3 - Article. C2 - 26077577. AN - SCOPUS:84930817420. VL - 122. SP - 2363. EP - 2364. JO - Ophthalmology. JF - Ophthalmology. SN - 0161-6420. IS - 11. ER - ...
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Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy Shinichi Usui,1,2 Yasushi Ikuno,2 Sato Uematsu,1 Yuko Morimoto,1 Yoshiaki Yasuno,3 Yasumasa Otori11National Hospital Organization, Osaka National Hospital, Osaka, Japan; 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 3Computational Optics Group, University of Tsukuba, Tsukuba, JapanPurpose: To evaluate changes in axial length and choroidal thickness after trabeculectomy.Patients and methods: Fourteen patients under 80 years of age with glaucoma, were enrolled. The choroid was imaged using prototypical high-penetration optic coherence tomography (OCT) and the thickness was measured. Axial length, choroidal thickness, and intraocular pressure (IOP) were measured bilaterally at 3 pm 1 day before and 6 days after trabeculectomy. The choroidal thickness was measured at the fovea and four other locations (2 mm superior, temporal, inferior, and nasal to
Relevance of choroidal change in glaucoma has long been a focus of interest in glaucoma research. The interest has been boosted recently since the description of parapapillary choroidal microvascular dropout (MvD) using OCT Angiography (OCTA) in glaucomatous eyes. It is acknowledged that choroidal thickness varies according to IOP change. Particularly, several studies demonstrated choroidal thickening weeks or months after trabeculectomy. However, there has been paucity in the literature about longer term effect of IOP lowering on the choroidal thickness. Kojima et al. reported thickening of the macular and peripapillary choroidal thickness after one year after trabeculectomy. Interestingly, the thickening was mostly due to the increases in the interstitial areas, while the luminal area was comparable to the preoperative state.. An interesting issue regarding the role of choroid in glaucoma is that how the optic nerve head perfusion is related with choroid. While the choroid is responsible for ...
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Hirooka et al [31]는 맥락막 혈관의 소실 및 혈류감소로 인하여 정상안압녹내장군의 맥락막두께가 대조군에 비해 얇다고 보고하였으며, Usui et al [32]는 고도근시가 동반된 정상 안압녹내장 환자을 대상으로 한 연구에서 녹내장군이 대조군보다 유두주위 맥락막두께가 얇다고 보고한 바 있다. Park et al [13]은 개방각녹내장 환자를 대상으로 한 연구에서 시신경유두 및 주변 조직의 관류부전과 혈관들의 비정상적인 자가조절로 인해 녹내장군이 대조군보다 유두주위 맥락막두께가 얇다고 보고하면서, 정상안압녹내장의 허혈성 손상과 관련된 해부학적 증거를 제시하였다. Karahan et al [12]은 시신경유두 경계로부터 500 μm, 1,000 μm, 1,500 μm 거리의 맥락막두께를 측정하여 개방각녹내장 환자군이 대조군에 비해 맥락막두께가 얇으며, 개방각녹내장 환자군에서 유두주위 ...
3D swept-source OCT detected FCE in 9 eyes (7.8 %). The 3D scanning protocol ‎allowed for detection of small extrafoveal excavations and the 3D segmentation method ‎coupled with en-face scans allowed for clear visualization of the morphology of the ‎excavations. In 5 eyes with FCE, unusual choroidal tissue was detected beneath the ‎FCE, bridging between the bottom of FCE and the outer choroidal boundary. In addition, ‎three of those five eyes showed a suprachoroidal space below the FCE, as if the outer ‎boundary of choroid is pulled inward by this bridging tissue. FCE was often seen within ‎the leakage point and choroidal hyperpermeability. Eyes with FCE were more myopic ‎‎(-4.42 ± 2.92 diopters), and the subfoveal choroidal thickness was significantly thinner ‎‎(301.3 ± 60.1 µm), as compared to control CSC eyes (P = .001 and .036 respectively ...
Results Of the 462 recruited participants, 273 had no diabetes (mean age was 60.1±6.8 years), 100 had diabetes but no DR (61.8±7.4 years) and 89 had DR (62.4±6.0 years). In multiple regression analysis, after accounting for relevant confounders, compared with those without diabetes, participants with diabetes had significantly thinner mean choroidal thickness (CT; mean difference (MD)=−25.19 µm, p=0.001), smaller choroidal volume (MD=−0.23 mm3, p=0.003), more inflection points (MD=1.78, p,0.001) and lesser choroidal vascular area within the foveal (MD=−0.024 mm2, p=0.001) and macular (MD=−0.095 mm2, p,0.001) regions. Among the diabetic group, subjects with DR had significantly thicker mean CT (MD=25.91 µm, p=0.001), greater choroidal volume (MD=0.24 mm3, p=0.009), lesser inflection points (MD=−0.478, p=0.045) and greater choroidal vascular area at foveal (MD=0.016 mm2, p=0.019) and macular (MD=0.057 mm2, p=0.016) regions, compared with those without DR. ...
TY - JOUR. T1 - Improved leukocyte tracking in mouse retinal and choroidal circulation.. AU - Xu, Heping. AU - Manivannan, A.. AU - Goatman, K.. AU - Liversidge, J.. AU - Sharp, P.F.. AU - Forrester, J.V.. AU - Crane, I.J.. PY - 2002. Y1 - 2002. UR - http://www.scopus.com/inward/record.url?scp=0036351925&partnerID=8YFLogxK. U2 - 10.1006/exer.2001.1134. DO - 10.1006/exer.2001.1134. M3 - Article. C2 - 12014921. VL - 74(3). SP - 403. EP - 410. JO - Experimental Eye Research. JF - Experimental Eye Research. SN - 0014-4835. IS - 3. ER - ...
Advances in the discovery of the causes of monogenic retinal disorders, combined with technologies for the delivery of DNA to the retina, offer enormous opportunities for the treatment of previously untreatable blinding diseases. However, for gene augmentation to be most effective, vectors that have the correct cell-type specificity are needed. While animal models are very useful, they often exhibit differences in retinal cell surface receptors compared to human retina. In this study, we evaluated the use of an ex vivo organotypic explant system to test the transduction efficiency and tropism of 7 different adeno-associated viral type 2 (AAV2) serotypes in human retina and retinal pigment epithelium-choroid: AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9, all driving expression of GFP under control of the cytomegalovirus promoter. After 7 days in culture, we found that AAV2/4 and AAV2/5 are particularly efficient at transducing photoreceptor cells and that AAV2/5 is highly specific ...
Advances in the discovery of the causes of monogenic retinal disorders, combined with technologies for the delivery of DNA to the retina, offer enormous opportunities for the treatment of previously untreatable blinding diseases. However, for gene augmentation to be most effective, vectors that have the correct cell-type specificity are needed. While animal models are very useful, they often exhibit differences in retinal cell surface receptors compared to human retina. In this study, we evaluated the use of an ex vivo organotypic explant system to test the transduction efficiency and tropism of 7 different adeno-associated viral type 2 (AAV2) serotypes in human retina and retinal pigment epithelium-choroid: AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9, all driving expression of GFP under control of the cytomegalovirus promoter ...
This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Haibo Wang, Yanchao Jiang and M. Elizabeth Hartnett. Thy-1 regulates VEGF-induced choroidal endothelial cell migration Dept of Ophthalmology, John A. Moran Eye Center, The University of Utah-Salt Lake City. Purpose: Choroidal endothelial cell (CEC) activation and migration […]. ...
Retrospective study of pediatric patients with SCD followed in the medical retina unit of Jules-Gonin Eye Hospital .The study group was compared to a control group matched for age, sex and ethnicity. Retinal thinning, macular splaying (foveal diameter), foveal depth and subfoveal choroidal thickness were measured using OCT (Heidelberg Engineering, Germany ...
VEGF-PEDF balance is altered in RPE/choroids from mice exposed to HQ.(A) VEGF and (B) PEDF mRNA expression in response to HQ-induced oxidative injury. Total RNA
Three aims are proposed to study the chorioretinal complex (choroid, choriocapillaris, Bruchs membrane, retinal pigment epithelium, photoreceptors) in age-rela...
OCT angiography (OCTA) is a revolutionary new tool that adds value to clinical practice. It provides unique insights about retinal and choroidal vasculature compared with conventional OCT along with the advantages of conventional dye-based techniques, said Philip J. Rosenfeld, MD, PhD, at the 2017 Retina Subspecialty Day meeting.
TY - JOUR. T1 - Effects of timolol and betaxolol on choroidal blood flow in the rabbit. AU - Kiel, J. W.. AU - Patel, P.. PY - 1998/11. Y1 - 1998/11. N2 - This study evaluated the effects of the topical β-adrenergic antagonist betaxolol and the non-selective β-adrenergic antagonist timolol on the choroidal pressure-flow relationship. Pentobarbital-anesthetized rabbits were instrumented with hydraulic occluders on the aorta and inferior vena cava to control MAP an ear artery cannula to measure mean arterial pressure (MAP), and two vitreous cannulas to control and measure intraocular pressure (IOP). Choroidal blood flow was measured by laser Doppler flowmetry with the fiber- optic probe tip positioned over the posterior pole. Choroidal pressure-flow curves were obtained before and 30 min after topical application of 0.1 ml of betaxolol (Betoptic, 0.5%, n = 10), timolol (Timoptic, 0.5%, n = 10) or saline (n = 8) by varying the MAP without controlling the IOP and by raising IOP while holding the ...
Polypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases. The presence of pachyvessels is one of the characteristics of pachychoroid disorders. However, the relationship between the presence of pachyvessels and the clinical characteristics of PCV eyes has not been determined. The purpose of this study was to determine the relationship between the presence of choroidal pachyvessels and the clinical characteristics of eyes with PCV. The medical records of patients who were diagnosed with PCV and were treatment-naïve were reviewed. Fluorescein and indocyanine green angiography, fundus photography, spectral domain optical coherence tomography (SD-OCT), and enhanced depth imaging OCT (EDI-OCT) were used to obtain images of the choroid. The presence of pathologically dilated outer choroidal vessels, pachyvessels, was determined by ICGA images. These pachyvessels were confirmed to correspond with the large choroidal vessels in the EDI OCT images. The PCV eyes
This study aimed to analyze the choroidal characteristics in eyes with polypoidal choroidal vasculopathy (PCV, affected eyes) and unaffected fellow eyes, a
Polypoidal choroidal vasculopathy (PCV) is a disease of the choroidal vasculature.  It is present in both men and woman of many ethnicities, characterized by serosanguineous detachments of the pigmented epithelium and exudative changes that can commonly lead to subretinal fibrosis. Evidence supports that symptomatic patients with PCV can have complete regression without severe vision loss with photodynamic therapy (PDT) and anti-VEGF treatment.  
Polypoidal choroidal vasculopathy (PCV) is a degenerative macular disease. The study determined the topographical concordance in the areal extent of PCV, defined by indocyanine green angiography (ICGA), and the corresponding outcomes from spectral-domain optical coherence tomography (SD-OCT) and microperimetry, in 25 individuals (25 eyes) who had undergone 3 months of anti-vascular endothelial growth factor treatment. The differential light sensitivity within 10° eccentricity was evaluated by Pattern Deviation probability analysis. The concordances and proportional areal extents of the abnormality for ICGA, SD-OCT and microperimetry were compared. The concordance in the areal extent between all three modalities was 59%. The median concordance between ICGA and microperimetry was 60%; between ICGA and SD-OCT, 70%; and between SD-OCT and microperimetry, 72%. SD-OCT and microperimetry each identified a greater areal extent (,20%) compared to ICGA in 13 and 19 eyes, respectively. A greater areal ...
PurposeRecent studies have found a choroidal thickening in amblyopic eyes and suggested that there might be a relationship between the choroid and amblyopia. The present study aimed to evaluate the effect of a six-month treatment of amblyopia on choroidal thickness in anisometropic hyperopic amblyopic children. ...
PURPOSE To compare the 12-month real-world visual and disease activity outcomes of eyes with polypoidal choroidal vasculopathy (PCV) treated with a combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) injections (combination group) versus those eyes treated with anti-VEGF monotherapy alone with rescue PDT being used as required (monotherapy group). DESIGN Database comparative observational study. PARTICIPANTS Eyes with PCV as graded in the Fight Retinal Blindness! database from Australia, New Zealand, Singapore, and Switzerland. METHODS Clinical information from a multisite, international registry of neovascular age-related macular degeneration was analyzed with an intention-to-treat approach. MAIN OUTCOME MEASURES Primary outcome measure was the change in visual acuity in logMAR letters over 12 months between the two groups analyzed with intention-to-treat approach. RESULTS Forty-one and 152 eyes received combination therapy and anti-VEGF monotherapy, ...
Macular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in healthy individuals using spectral domain optical coherence tomography (SD-OCT). Case-control study of 21 patients with AU and 23 patients with IMU and 34 age-matched healthy controls was performed with Spectralis SD-OCT (Heidelberg Engineering, Germany). High resolution SD-OCT scans and macular mapping were applied for automated measurement of retinal thickness. Standardized, masked manual measurement of the choroidal thickness was performed in the center of the ETDRS fields on enhanced depth imaging (EDI) scans. Evaluation of central retinal subfield thickness, 3 mm and 6 mm perifoveal rings was performed in the corresponding ETDRS zones in patient groups. The mean central retinal subfield thickness was significantly higher in IMU (368.65 ± 115.88 μm, p = 0.0003), but not significantly
Summary: The purpose of the study is to analyse the effectiveness of pedicled RPE (retinal pigment epithelium) - choroid graft autotranslocation in scarred neovascular age-related macular degeneration (AMD) treatment. Material and Methods. Pedicled RPE - choroid graft autotranslocation was performed on 8 patients with scarred wet AMD. Follow-up was from 6 to 30 months. Visual acuity, ophthalmoscopy, optical coherent tomography and indocian-green angiography were analysed. Results. The average visual acuity increased from 0.009±0.006 to 0.018±0.022 (p=0.15). Visual acuity increased in 50% of the patients. In 50% of patients visual acuity decreased, which was associated with proliferative vitreoretinopathy in post-op period with retinal detachment formation. No cases of choroidal neovascularization recurrence were detected. According to angiography data normal choroidal perfusion in the rotated RPE - choroid patch was revealed after 1 month during the follow-up examination. Conclusion. Pedicled ...
Polypoidal choroidal vasculopathy (PCV) primarily affects pigmented individuals, especially Asians and African-Americans. Typically presents in 7th to 8th decad
Fingerprint Dive into the research topics of Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging Optical Coherence Tomography Using Different Posterior Boundaries. Together they form a unique fingerprint. ...
The present study looked at the CT in POAG subjects (cases) compared with normal healthy subjects (controls) using SD-OCT and SS-OCT at the peripapillary and subfoveal locations. In our study, the CT measured on SD-OCT in cases was found to be thicker compared with controls in both peripapillary and macular area, however this difference was not statistically significant. The lower confidence limit of mean difference at all the points was in negative values on SD-OCT and a few points in SS-OCT, implying that in few patients the CT was thin in cases compared with controls. Similarly, a meta-analysis by Zhang et al (evaluating 22 studies) compared CT in glaucoma and normal subjects using EDI mode SD-OCT and found no significant difference in CT in POAG and normal subjects.6 This observation on SD-OCT might be due to poor sclerochoroidal delineation.. On SS-OCT, we found thicker CT in cases compared with controls in peripapillary and macular area, but only PPCT was statistically significantly ...
Choroid is one of the structural layers, playing a significant role in physiology of the eye and lying between the sclera and the retina. The segmentation of this layer could guide ophthalmologists in diagnosing most of the eye pathologies such as choroidal tumors and polypoidal choroidal vasculopathy. High signal-to-noise ratio and high speed imaging in Spectral-Domain Optical Coherence Tomography (SD-OCT) make choroidal imaging feasible. Several variables such as pre-operative axial length (AXL), time of day and age affect thickness of the choroidal vascularization and should be considered for segmentation of this layer. These days most of the eye specialists manually segment the choroidal layer which is time-consuming, tiresome and dependent on human errors. To overcome these difficulties, some studies have introduced different automatic choroidal segmentation methods. In this paper, we have conducted a comprehensive review on existing recently published methods for automatic choroidal segmentation
Inclusion Criteria: Subject must be ,/= 55 years of age; Subject must have evidence of advanced dry AMD, defined by the characteristic presence of drusen and/or pigmentary changes as well as geographic atrophy; Subject must have clear ocular media and adequate pupillary dilation; Subject must be able to swallow capsules; Study eye must have best corrected visual acuity (BCVA) of 20/20-20/400; Subject must be willing and able to pay for monthly prescription of Metformin HCl, for 18 months in the event that their insurance carrier will not cover the costs of the drug. Exclusion Criteria: Subjects with insufficient baseline size of geographic atrophy, less than 1.25 mm2 (0.5 Macular Photocoagulation Study Disc Areas). GA is defined as one or more well-defined and often circular patches of partial or complete depigmentation of the RPE, typically with exposure of underlying choroidal blood vessels. Even if much of the RPE appears to be preserved and large choroidal vessels are not visible, a round ...
The market presents significant growth opportunities for vendors. Companies are increasingly forming strategic alliances and engaging in M&A to increase their market share. As the development cost of ophthalmic drugs is high, small biotechnology firms are forming alliances with big pharmaceutical companies for product development.. Ask Sample PDF of Choroidal Neovascularization Market Report @ http://www.marketreportsworld.com/enquiry/request-sample/10278447 According to the Choroidal Neovascularization report, Better infrastructure in terms of healthcare facilities and sophisticated treatment options has led to a rise in the life expectancy rates, leading to a rise in the number of people over 60 years. The normal aging process results in reduced choroidal blood flow, which leads to ischemia. This, in turn, leads to increased expression of VEGF and development of excess blood vessels resulting in choroidal neovascularization and finally the loss of vision. With the increase in older ...
Human Choroid Plexus Endothelial Cells https://www.sciencepro.com.br/produtos/sc-1300 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
Human Choroid Plexus Fibroblast cDNA https://www.sciencepro.com.br/produtos/sc-1324 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
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The proposed study aims to evaluate the efficacy of a modified treat and extend regime based on disease activity with aflibercept monotherapy for PCV.
Choroidal Neovascularization - Pipeline Review, H2 2017 Choroidal Neovascularization - Pipeline Review, H2 2017 Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Market research report and industry analysis - 11207704
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral and peripheral vascular disease, including ocular diseases like age-related macular degeneration or diabetic retinopathy. Data of a recent study performed in the investigators lab revealed abnormal choroidal blood flow regulation in chronic smokers as compared to age-matched non-smoking subjects during isometric exercise. However, no information is yet available about the regulation of retinal vascular tone in habitual smokers.. Thus, in the current study, the investigators set out to investigate whether the regulation of retinal vessels diameters is affected in habitual smokers. It has been shown in several reports that stimulation with diffuse luminance flicker, increases retinal arterial and venous diameters, indicating for the ability of the retina to adapt to changing metabolic demands. In the current study we use this effect as a tool to investigate whether the flicker induced vasodilatation is ...
The patient was a 15-year-old girl with an established diagnosis of Alagille syndrome (AS) since early life. Her medical history was significant for systemic manifestations of AS including liver transplantation and pulmonary artery balloon dilation. She had an unusual triangular facies characterized by a broad overhanging forehead, deep set, hyperteloric eyes and small pointed chin. Her bestcorrected visual acuity was 1.0 in both eyes. Slit-lamp examination was positive for posterior embryotoxon in both eyes. Funduscopy revealed diffuse choroidal hypopigmentation with increased visibility of the choroidal vessels and symmetric, well-circumscribed macular discoloration (Figure 1). A circumferential chorioretinal atrophy was also detected in the peripheral retina (Figure 1). Fundus autofluorescence (FAF) imaging clearly defined hypofluorescent areas in the peripapillary regions that extended along the macula and had a sleep mask appearance (Figure 2). Peripheral circumferential chorioretinal ...
Previous studies have shown that wild-type retinas implanted with subretinal devices undergo photoreceptor degeneration in the region immediately overlying the device.5,18 The death of photoreceptors was attributed to the blockage of choroidal blood flow to the outer retina due to the solid nature of the subretinal implant. The inclusion of perforations was hypothesized to increase the health of the retina overlying the device. Our results show that INL thickness on the stimulating side of the IPA in retinas with solid IPAs is the same as IPAs with 5-μm perforations (Fig. 4). This indicates that the INL is less sensitive to the blockage of choroidal blood flow than the photoreceptors. Furthermore, the retinas with solid IPAs do not form pseudo-rosettes or undergo glial fibrosis, compared with IPAs with perforations. While the mechanism of retinal pseudo-rosette formation is unclear, higher rates have been observed in several retinal pathologies including retinal detachment,27 retinal ...
Synonyms for choroid inflammation in Free Thesaurus. Antonyms for choroid inflammation. 1 synonym for choroid: choroid coat. What are synonyms for choroid inflammation?
Choroidal neovascular are the new blood vessels that grow just below the retina and interrupt the vision. Choroid, which is responsible for oxygen and nutrients supply to the eye, is the area between the retina and the sclera, where the blood vessels grow and cause choroidal neovascularization (CNV).
The posterior choroidal artery is not in fact a single artery, although it is commonly referred to as such. The posterior choroidal arteries, often numbering up to 10 or 11 per hemisphere, are divided into medial posterior choroidal artery and la...
Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Pipeline Review, H2 2017, provides an overview of the Choroidal
This is a 2-step process combining a light-activated drug called Visudyne (verteporfin) with light from a cold laser directed onto the abnormal area of retina. Once activated, the drug causes the abnormal vessels to close off. PDT does not cause direct damage to the surrounding retina. Therefore, it can be used to treat new vessels that are under the centre of the macula (fovea).. Several treatments are needed to keep the leaking blood vessels closed and stop the progression of wet MD. Close follow up and monitoring is needed to determine if further treatment is required.. Unlike anti-VEGF drugs with which the vision is usually maintained, patients undergoing PDT continue to lose vision in the first 6 months. Their vision then stabilises so that the eye does not progress to severe vision loss.. PDT is now rarely used to treat ordinary wet MD. It is sometimes used in conjunction an anti-VEGF drug to treat a type of MD called polypoidal choroidal vasculopathy (PCV) as some of these cases do not ...
TY - JOUR. T1 - Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy with Single or Multiple Polyps. AU - Suzuki, Misa. AU - Nagai, Norihiro. AU - Shinoda, Hajime. AU - Uchida, Atsuro. AU - Kurihara, Toshihide. AU - Tomita, Yohei. AU - Kamoshita, Mamoru. AU - Iyama, Chigusa. AU - Tsubota, Kazuo. AU - Ozawa, Yoko. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Purpose: To understand the prognosis of polypoidal choroidal vasculopathy (PCV) by evaluating the responsiveness to intravitreal ranibizumab (IVR) monotherapy according to the presence of a single or multiple polyps. Design: Retrospective case series. Methods: We included 48 treatment-naïve eyes of 48 patients who received IVR monotherapy at the Medical Retina Division Clinic, Keio University Hospital between March 2009 and January 2013 and attended the clinic for at least 12 months. All patients received 3 monthly IVR injections followed by pro re nata injections and were divided into single polyp and ...
In the current study, quantitative mapping of choroidal thickness and volume and qualitative analysis of choroidal vascular integrity showed loss of choroidal tissue including the choriocapillaris layer in the convalescent stage of VKH. Additionally, loss of the choriocapillaris and the thinning of the choroid in the sub-macula area correlated with increased duration of the disease, lower VA, and the presence of structural changes in the retina.. Normal sub-foveal choroidal thickness measured by SD-OCT ranges from 260 to 287 μm and varies by age, refractive error, and ethnicity [24-26]. Choroidal thickness varies based on the nature of posterior segment pathology as well. For instance, choroidal thickness increases in hyperopia [24], acute VKH [14, 15, 18], central serous chorioretinopathy [27, 28], and polypoid choroidal vasculopathy [29, 30]. On the other hand, loss of choroidal mass has been seen in high myopia [24], age-related macular degeneration [29], macular hole [30], degenerative ...
TY - JOUR. T1 - Experimental deprivation of choroidal blood flow. Retinal morphology, early receptor potential, and electroretinography. AU - Buettner, Helmut. AU - Machemer, Robert. AU - Charles, Steve. AU - Anderson, Douglas R.. PY - 1973/6. Y1 - 1973/6. N2 - Experimental deprivation of the choroidal blood flow up to 24 hours in owl monkey eyes resulted in final necrosis of the pigment epithelium and photoreceptor cells. Müller cells did not show morphologic deterioration. The inner retinal layers exhibited marked extracellular edema, but no intracellular or vascular damage. The electroretinograms B-wave disappeared early, followed by the disappearance of the A-wave, but the early receptor potential remained intact for 12 hours. The electrophysiologic changes correlate well with the sequence of morphological changes. These findings show that retinal pigment epithelium and photoreceptors depend mostly on supply from the choridal circulation. The extracellular edema of the inner retinal layers ...
TY - JOUR. T1 - Selective visualization of choroidal neovascular membranes. AU - Asrani, Sanjay. AU - Zou, Shazhou. AU - DAnna, Salvatore. AU - Phelan, Anne. AU - Goldberg, Morton. AU - Zeimer, Ran. PY - 1996/7. Y1 - 1996/7. N2 - Purpose. Laser-targeted angiography has unique advantages over conventional angiography of the fundus. Its efficacy in visualizing choroidal neovascular membranes was tested in a rat model and compared to that of fluorescein angiography. Method. Laser-targeted angiography was performed in rats with choroidal neovascularization (CNV) by injecting heat-sensitive carboxyfluorescein liposomes intravenously, locally releasing a bolus of dye in the choroid with a weak laser pulse, and recording advancement of the bolus on a video camera. Conventional fluorescein angiography also was performed. Results. Laser- targeted angiography revealed CNV as an abnormal pattern of brightly fluorescent vessels. The flow pattern of the bolus and histology, performed in some cases, ...
TY - JOUR. T1 - Influence of the time of day on axial length and choroidal thickness changes to hyperopic and myopic defocus in human eyes. AU - Moderiano, Daniel. AU - Do, Michelle. AU - Hobbs, Sam. AU - Lam, Vy. AU - Sarin, Simran. AU - Alonso-Caneiro, David. AU - Chakraborty, Ranjay. PY - 2019/5. Y1 - 2019/5. N2 - Research in animal models have shown that exposing the eye to positive or negative spectacle lenses can lead to predictable changes in eye growth. Recent research indicates that brief periods (1-2 h) of monocular defocus results in small, but significant changes in axial length and choroidal thickness of human subjects. However, the effects of the time of day on these ocular changes with defocus are not known. In this study, we examined the effects of monocular myopic and hyperopic defocus on axial length and choroidal thickness when applied in the morning (change between 10 a.m. and 12 p.m.) vs the evening (change between 5 and 7 p.m.) in young adult human participants (mean age, ...
In this article the ability of ultrahigh resolution ophthalmic optical coherence tomography (OCT) to image small choroidal blood vessels below the highly reflective and absorbing retinal pigment epithelium is demonstrated for the first time. A new light source (λc=1050 nm, Δλ=165 nm, Pout=10 mW), based on a photonic crystal fiber pumped by a compact, self-starting Ti:Al2O3 laser has therefore been developed. Ex-vivo ultrahigh resolution OCT images of freshly excised pig retinas acquired with this light source demonstrate enhanced penetration into the choroid and better visualization of choroidal vessels as compared to tomograms acquired with a state-of-the art Ti:Al2O3 laser (Femtolasers Compact Pro, λc=780 nm, Δλ=160 nm, Pout=400 mW), normally used in clinical studies for in vivo ultrahigh resolution ophthalmic OCT imaging. These results were also compared with retinal tomograms acquired with a novel, spectrally broadened fiber laser (MenloSystems, λc=1350 nm, Δλ=470 nm, Pout=4 mW) ...
Choroidal neovascularization (CNV) is a key pathological feature of several of the leading causes of vision loss including neovascular age-related macular degeneration. Here we show that a calreticulin anti-angiogenic domain (CAD)-like peptide 27, CAD27, inhibited in vitro angiogenic activities, including tube formation and migration of endothelial cells, and suppressed vascular sprouting from rat aortic ring explants. In rat model of laser-induced CNV, we demonstrate that intravitreal injection of CAD27 significantly attenuated the formation of CNV lesions as measured via fundus fluorescein angiography and choroid flat-mounts (19.5% and 22.4% reductions at 10μg and 20μg of CAD27 injected, respectively). Similarly, the reduction of CNV lesions was observed in the groups of rats that had received topical applications of CAD27 (choroid flat-mounts: 17.9% and 32.5% reductions at 10μg/mL and 20μg/mL of CAD27 installed, respectively). Retinal function was unaffected, as measured using
To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD). In this cross-sectional study, 22 eyes of 22 patients (mean age: 75 ± 9.02 years) with intermediate AMD were enrolled. Retinal sensitivity and bivariate contour ellipse area (BCEA) were obtained by microperimetry MP-1 (Humphrey 10-2 68-loci grid) under mesopic conditions. Drusen type, drusenoid pigment epithelial detachment, hyperreflective foci (HF), integrity of external limiting membrane (ELM), inner ellipsoid zone (ISel), RPE/Bruchs membrane complex (RPE/B) and subfoveal choroidal thickness were analyzed in the foveal region and compared with RS and BCEA. Spearmans rank correlation coefficient was used to evaluate the relationship between variables. Logistic regression analysis was also used to assess morphological predictor influencing RS or BCEA. RS was strongly and inversely related with the presence of HF (r =
Case Reports; Letter; Aged; Choroid Diseases; Coloring Agents; Female; Fluorescein Angiography; Humans; Inclusion Bodies; Indocyanine Green; Photochemotherapy; Polyps; Retinal Pigment Epithelium; Subretinal Fluid; Tomography, Optical Coherence; Visual Acuity ...
BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a dry operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. Choroidal blood flow decreased by 24 +/- 0.3% and 22 +/
I am a 40 years old man suffered from choroidal neovascular membrane (CNVM) 2 years back in the right eye. I took Avastin at that time. The blood dried but it left a scar on that place and I lost the vision of my right eye. Now |b|I have developed black spots and lines in my other eye too|/b|, which is causing pain in both the eyes and I am facing problem in reading too. How can I save my left eye? Is there any treatment for the CNVM scar?
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin. Nakama, T; Yoshida, S; Ishikawa, K; Kobayashi, Y; Zhou, Y; Nakao, S; Sassa, Y; Oshima, Y; Takao, K; Shimahara, A; Yoshikawa, K; Hamasaki, T; Ohgi, T; Hayashi, H; Matsuda, A; Kudo, A; Nozaki, M; Ogura, Y; Kuroda, M; Ishibashi, T // Gene Therapy;Feb2015, Vol. 22 Issue 2, p127 Age-related macular degeneration (AMD) is a vision-threatening disease characterized by choroidal fibrovascular membrane (FVM) formation, choroidal neovascularization (CNV) and choroidal fibrosis. No safe and effective therapeutic method has been developed for the choroidal fibrosis, although... ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
This prospective, cross-sectional and comparative study include 31 eyes of 31 patients with nanophthalmos and 31 eyes of 31 healty subjects (control group). Subfoveal choroidal thickness and central macular thicness (CMT) were measured with spectral domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg Engineering) with enhanced depth imaging (EDI) and fast macular thickness mode. Also, all participants underwent a standardised ocular examination including central corneal thickness (CCT), anterior chamber depth (ACD), refractive errors measurements ...
Abstract Importance Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) of cellular degeneration. Optical coherence tomography angiography allows for choriocapillaris (CC) imaging. We compared the extent of structural alterations of the CC, retinal pigment epithelium, and photoreceptors with multimodal imaging. Observations In a clinical case series conducted from September 15, 2014, through February 5, 2015, 14 eyes of 7 male patients with choroideremia (median age, 34 years [interquartile range, 15-46 years]; age range, 13-48 years), 4 eyes of 2 women with choroideremia carrier state (both in mid-50s), and 6 eyes of 6 controls (median age, 42.5 years [interquartile range, 33-55 years]; age range, 24-55 years) underwent multimodal imaging with optical coherence tomography angiography and electroretinography. The mean (SD) macular CC density was 82.9% (13.4%) in patients with choroideremia, 93.0% (3.8%) in female
Choroidal neovascularization describes the growth of new blood vessels that originate from the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium (sub-RPE) or subretinal space. Choroidal neovascularization (CNV) is a major cause of visual loss.
In order to find abnormal blood vessels under the retina and/or to identify conditions that can cause retinal swelling and reduced vision, it is sometimes necessary to perform a test called angiography.. This test is performed by injecting a dye into the vein of the arm, then photographing the dye as it passes through the circulation in the back of the eye. Depending on the pattern of dye transmission and leakage, certain disease processes can be identified. Two different dyes are commonly used: fluorescein and indocyanine green. Special digital cameras joined to computers are used to maximize the effectiveness of this test.. Doctors choose fluorescein angiography to study diseases of the retinal and choroidal blood vessels within the eye. The results of this test enable the physician to diagnosis many abnormalities of the retina and choroid that could not be diagnosed accurately otherwise. The results of this study also serve as a guide to laser treatment for many diseases of the retina and ...
Kelly graduated with a Bachelor of Arts degree with a moderatorship in Genetics from Trinity College Dublin in 2012.. After graduation, she worked as a Research Assistant at Trinity College Dublin, in the laboratory of Dr. Sarah Doyle, investigating the role of IL-18 in Age Related Macular Degeneration.. In 2014 Kelly began pursuing her PhD in the laboratory of Dr. Sarah Doyle at Trinity College Dublin. She received her PhD in Clinical Medicine from the Department of Clinical Medicine, School of Medicine at Trinity College Dublin with the dissertation, Investigating A Role for TLR Signaling and Complement Deposition in Retinal Degeneration in 2018.. Kelly joined the lab in October 2018 as a Postdoctoral Research Scholar supervised by Dr. Robert Mullins and Dr. Budd Tucker. The focus of her research is on the role of choriocapillaris in early AMD pathogenesis and investigating methods to rescue or replace choroidal endothelial cells.. ...
(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western blot showed that (R,R)ZX-5 up-regulated the expression of Akt, p-Akt (Thr473), eNOS and p-eNOS (Ser1177), down-regulated the expression of Cyclin D1 in human retinal endothelial cells and escalated the intracellular free Ca2+ concentration. Additionally, (R,R)ZX-5 inhibited the growth of blood vessels in the chick chorioallantoic membrane model. It is concluded that (R,R)ZX-5 promotes choroidal blood flow through PI3K/Akt-eNOS and Akt-Ca2+-eNOS pathways. Additionally, (R,R)ZX-5 can inhibit angiogenesis.
For Lasik, cataract surgery and general eye care, Eye Clinic & Laser Institute has been serving Merritt Island, Cocoa Beach, Melbourne-Palm Bay, Viera, Titusville and Brevard County since 1980. We were the first to bring LASIK to our local community in 1997 and are the only eye surgeons in Brevard to provide BLADELESS CATARACT LASER SURGERY (2013).
Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
Multifocal choroiditis is an inflammatory disease that causes visual loss in 70 % of patients. It usually occurs in 30 to 60-year-old healthy myopic females. Most cases are bilateral or become bilateral over time.. Fundoscopic findings include small, round, discrete and gray-yellowish spots located at the level of the retinal pigment epithelium and choriocapillaris, most often in the mid-periphery. As these lesions age and become inactive, they become atrophic and punched-out.. Patients may have variable amounts of anterior segment inflammation and vitritis.. Peripapillary and macular choroidal neovascularization may occur in 25-32 % of the patients.. Differential Diagnosis. ...
New blood vessel growth beneath the macula (choroidal neovascularization, CNV) can develop in some patients with with otherwise normal eyes.
Malignant choroidal melanoma (MCM) is a rare diagnosis, although it is the most commonly reported intraocular malignancy. Furthermore, the choroid is the second most common site that melanomas occur.…Malignant Choroidal Melanoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
TY - JOUR. T1 - VEGF 165b in the developing vasculatures of the fetal human eye. AU - Baba, Takayuki. AU - Mcleod, D. Scott. AU - Edwards, Malia. AU - Merges, Carol. AU - Sen, Tanusree. AU - Sinha, Debasish. AU - Lutty, Gerard Anthony. PY - 2012/3. Y1 - 2012/3. N2 - VEGF 165b is an anti-angiogenic form of VEGF 165 produced by alternative splicing. The localization of pro-angiogenic VEGF 165 and anti-angiogenic VEGF 165b was investigated during development of the vasculatures in fetal human eyes from 7 to 21 weeks gestation (WG). The fetal vasculature of vitreous, which includes tunica vasculosa lentis (TVL), had moderate VEGF 165 immunoreactivity at 7WG and very little VEGF 165b. Both forms were elevated at 12WG. VEGF 165 then decreased around 17WG when the TVL regresses but VEGF 165b remained elevated. In choroid, VEGF 165 was present in forming choriocapillaris (CC) and retinal pigment epithelium (RPE) at 7WG while VEGF165b was present in CC and mesenchymal precursors within the choroidal ...
This test is similar to fluorescein angiography in that a dye is injected into the vein in the arm and we take photographs over time to help us diagnose problems in the back of the eye. The difference, however, is that the dye is used to study mainly the choroidal circulation, or the layer of blood vessels underneath the retina. ICG angiography is used less frequently than fluorescein angiography, but it can be especially useful in cases where blood obscures visualization of the retina. ICG angiography is also performed with a digital (computerized) system at Retina Care Specialists, allowing for immediate interpretation by the physician.. ...
In this prospective study, 60 patients diagnosed with obesity (47 males) (mean age: 46.47 +/- 10.9 years) were included, of which 30 patients underwent bariatric surgery (Group A), and 30 patients underwent conservative management (exercise/diet) (Group B). Parameters including choroidal thickness (CT), choroidal vascularity index (CVI) and retinal capillary density index (CDI) and arteriovenous ratio (AVR) were measured at the baseline and three months follow up. 30 eyes (30 age and gender-matched) of normal participants were included for comparison ...
Video articles in JoVE about indocyanine green include Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography, Near-infrared Navigation System for Real-time Visualization of Blood Flow in Vascular Grafts, Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging, Fluorescent Dye Labeling of Erythrocytes and Leukocytes for Studying the Flow Dynamics in Mouse Retinal Circulation, An
Patient comes in for evaluation on a Choroidal Melanoma in the right eye. VA was 20/25 in both eyes. The melanoma is in the temporal aspect of the right eye. It measured at 0.7mm elevated after doing a BSCAN Ultrasound ...
Patient comes in for evaluation on a Choroidal Melanoma in the right eye. VA was 20/25 in both eyes. The melanoma is in the temporal aspect of the right eye. It measured at 0.7mm elevated after doing a BSCAN Ultrasound ...
1. Posterior medullary velum 2. Choroid plexus 3. Cisterna cerebellomedullaris of subarachnoid cavity 4. Central canal 5. ...
PRPH2 Choroid plexus papilloma; 260500; TP53 Choroideremia; 303100; CHM Chromosome 22q13.3 deletion syndrome; 606232; SHANK3 ... HOXA13 Gyrate atrophy of choroid and retina with or without ornithinemia; 258870; OAT Haddad syndrome; 209880; ASCL1 Hailey- ...
The majority of the CSF is formed in the choroid plexus and flows through the brain along a distinct pathway: moving through ... Cserr HF (April 1971). "Physiology of the choroid plexus". Physiological Reviews. 51 (2): 273-311. doi:10.1152/physrev.1971.51. ... which is expressed by specialized epithelial cells of the choroid plexus, and aquaporin-4 (AQP4), which is expressed by ...
"Extramedullary plasmacytoma confined to the choroid". Am J Ophthalmol. 131 (2): 277-8. doi:10.1016/s0002-9394(00)00706-6. PMID ...
Weiter JJ, Roh S (December 1992). "Viral infections of the choroid and retina". Infectious Disease Clinics of North America. 6 ...
This area is referred to as the atrium of the lateral ventricle, and is where the choroid plexus is enlarged as the choroid ... Calcification of the choroid plexus can occur, usually in the atrium. Position of lateral ventricles (shown in red). Drawing of ... Were it not for the choroid plexus, a cleft-like opening would be all that lay between the lateral ventricle and the thalamus; ... The stria terminalis forms the remainder of the roof, which is much narrower than at the body - the choroid plexus moves to the ...
"Bruch's membrane": Innermost layer of the choroid. Bibliotheca zoologica Verzeichnis der Schriften über Zoologie ..., Volume 1 ...
"Gyrate atrophy of the choroid and retina". National Institutes of Health. Retrieved 2012-08-23. Kim SJ, Lim DH, Kim JH, Kang SW ... The mechanism of gyrate atrophy of choroid and retina is thought to involve the toxicity of glyoxylate. Glutamate-5- ... Deficiency of OAT activities causes ornithine aminotransferase deficiency, also known as gyrate atrophy of choroid and retina. ... "OAT mutations and clinical features in two Japanese brothers with gyrate atrophy of the choroid and retina". Doc Ophthalmol. ...
The arteries of the choroid and iris. The greater part of the sclera has been removed. Iris, front view. Accommodation reflex ... The ciliary muscle develops from mesenchyme within the choroid and is considered a cranial neural crest derivative. The ciliary ...
Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ...
Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ...
It supplies the iris, ciliary body and choroid. The veinous drainage of CIA is : 4 vortex veins that drain into the ophthalmic ...
He also applied this technique to the retina/choroid in the rabbit and demonstrated not only force-induced displacements in ... Effect of ultrasound radiation force on the choroid. Invest Ophthalmol Vis Sci. 2013 Jan 10;54(1):103-9. Official Web Page at ... Effect of ultrasound radiation force on the choroid. Invest Ophthalmol Vis Sci. 2013;54(1):103. Coleman DJ, Lizzi FL, Silverman ...
The proposed cause of cerebral folate deficiency in the Kearns-Sayre syndrome is the failure of the mechanisms in the choroid ... Spector R, Johanson CE (2010). "Choroid plexus failure in the Kearns-Sayre syndrome". Cerebrospinal Fluid Res. 7: 14. doi: ...
"Katzuya Shimizu (八十八ヶ所巡礼) Guitar講師" [Katzuya Shimizu (88Kasyo Junrei) Guitar Teacher]. Choroidea Music School (in Japanese). ...
The CSF is primarily secreted by the choroid plexus; however, about one-third of the CSF is secreted by pia mater and the other ... A subarachnoid space exists between the arachnoid layer and the pia, into which the choroid plexus releases and maintains the ... The cranial pia mater joins with the ependyma, which lines the cerebral ventricles to form choroid plexuses that produce ... folding inward to create the tela chorioidea of the third ventricle and the choroid plexuses of the lateral and third ...
... is the innermost layer of the choroid. It is also called the vitreous lamina or Membrane vitriae, because of ... The retinal pigment epithelium transports metabolic waste from the photoreceptors across Bruch's membrane to the choroid. ...
2007). "[Choroid plexus cysts and risk of trisomy 18. Modifications regarding maternal age and markers]". Ceska Gynekol (in ... The most common intracranial anomaly is the presence of choroid plexus cysts, which are pockets of fluid on the brain. These ... choroid plexus cysts, underdeveloped thumbs and/or nails, absent radius, webbing of the second and third toes, clubfoot or ...
Most (about two-thirds to 80%) of CSF is produced by the choroid plexus. The choroid plexus is a network of blood vessels ... Unlike blood passing from the capillaries into the choroid plexus, the epithelial cells lining the choroid plexus contain tight ... Choroid plexus of the lateral ventricle produces CSF from the arterial blood provided by the anterior choroidal artery. In the ... A Na-K-Cl cotransporter and Na/K ATPase found on the surface of the choroid endothelium, appears to play a role in regulating ...
Singh, ArunD; Turell, MaryE (2010). "Vascular tumors of the retina and choroid: Diagnosis and treatment". Middle East African ...
"Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis". PLOS ONE. 8 (7): e69552. Bibcode:2013PLoSO...869552S ...
... choroid plexus papillomas, craniopharyngiomas, teratomas); even when they present, they are different from the inflammatory ...
Saito T, Hayasaka S, Yabata K, Omura K, Mizuno K, Tada K (Nov 1981). "Atypical gyrate atrophy of the choroid and retina and ... It is also found in the kidney, optical choroid, and parts of the central nervous system such the brain and microglial cells. ... Saito T, Omura K, Hayasaka S, Nakajima H, Mizuno K, Tada K (Dec 1981). "Hyperornithinemia with gyrate atrophy of the choroid ... Weleber RG, Kennaway NG, Buist NR (Aug 1981). "Gyrate atrophy of the choroid and retina. Approaches to therapy". International ...
Choroid); 17. Ora serrata, 18. Vitreous humor with 19. Hyaloid canal/(old artery), 20. Retina with 21. Macula or macula lutea, ...
Non-proliferative retinopathy is often caused by direct damage or remodeling of the small blood vessels supplying the retina.[8] Many common causes of non-proliferative damage include hypertensive retinopathy, retinopathy of prematurity, radiation retinopathy, solar retinopathy, and sickle cell retinopathy. There are three main mechanisms of damage in non-proliferative retinopathy: blood vessel damage or remodeling, direct retinal damage, or occlusion of the blood vessels. The first mechanism is indirect damage by altering the blood vessels that supply the retina. In the case of hypertension, high pressures in the system causes the walls of the artery to thicken, which effectively reduces the amount of blood flow to the retina.[8] This reduction in flow causes tissue ischemia leading to damage. Atherosclerosis, or hardening and narrowing of blood vessels, also reduces flow to the retina. The second mechanism is direct damage to the retina usually caused by free radicals that causes oxidative ...
Disorders of choroid and retina. Hidden categories: *Wikipedia articles needing page number citations from May 2015 ...
Über die Krankheiten der Choreida (1837) - On diseases of the choroid. Die Krankheiten des Höheren Alters und Ihre Heilung ( ...
The choroid is very thick and contains a fibrous tapetum lucidum. Like other toothed whales, the sperm whale can retract and ...
Choroidectomy is the removal of the choroid layer of the eye. Clitoridectomy is the partial or total removal of the external ...
While PCFT is expressed primarily at the basolateral membrane of the choroid plexus, FRα is expressed primarily at the apical ... As indicated above, PCFT is also expressed at the basolateral membrane of ependymal cells of the choroid plexus where it ... FRα-mediated endocytosis which plays an important role in the transport of folates across the choroid plexus into the CSF (see ... "Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma". Nature Communications. 4: 2123. doi: ...
The choroid is the layer of blood vessels and connective tissue between the white of the eye and retina (at the back of the eye ... The choroid is the layer of blood vessels and connective tissue between the white of the eye and retina (at the back of the eye ...
resembling the chorion; as, the choroid plexuses of the ventricles of the br... ... Cho"roid (?), a. [gr. ; chorion + form.] Anat. resembling the chorion; as, the choroid plexuses of the ventricles of the brain ... Choroid plexus Anat., one of the delicate fringelike processes, consisting almost entirely of blood vessels, which project into ...
Choroid. The choroid or choroid coat, in the rear five-sixths of the globe of the eye, is loosely joined to the sclera and is ... The choroid also contains numerous pigment-producing hormone cells that give it a brownish black appearance. The dark pigments ...
The choroid is the middle layer of the eye that contains blood vessels and connective tissue that supplies nutrients to the ... The choroid is the middle layer of the eye that contains blood vessels and connective tissue that supplies nutrients to the ...
Medical definition of choroid plexus: a highly vascular portion of the pia mater that projects into the ventricles of the brain ... Resources for choroid plexus. Time Traveler: Explore other words from the year choroid plexus first appeared Time Traveler! ... Comments on choroid plexus. What made you want to look up choroid plexus? Please tell us where you read or heard it (including ... Post the Definition of choroid plexus to Facebook Share the Definition of choroid plexus on Twitter ...
Choroid plexus papillomas are benign, slow-growing tumours. They are usually treated by surgery alone. These types of tumours ... Choroid plexus tumours. Choroid plexus tumours start in the part of the brain called the choroid plexus. The choroid plexus is ... Choroid plexus tumours are graded from I to III.* A grade I tumour is a non-cancerous (benign) tumour. It is called a choroid ... Treatment of choroid plexus tumours. Surgery is the most common treatment used for choroid plexus tumours. Surgery may be the ...
Definition of epithelial choroid layer. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ...
All MeSH CategoriesAnatomy CategoryNervous SystemCentral Nervous SystemBrainCerebral VentriclesChoroid Plexus ... Choroid Plexus. A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ...
Choroid plexus tumors (CPT) are rare tumors of the neuroepithelial tissue of the brain that are most common in young children. ... Choroid plexus Choroid plexus papilloma Atypical choroid plexus papilloma Choroid plexus carcinoma Radiation therapy ... There are three histopathological classifications of choroid plexus tumors: choroid plexus papilloma (CPP), atypical choroid ... Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid ...
Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea This article ... The choroid plexus or plica choroidea, is a plexus of cells that arises from the tela choroidea in each of the ventricles of ... A choroid plexus is in part of the roof of the fourth ventricle. The choroid plexus consists of a layer of cuboidal epithelial ... The choroid plexus consists of many capillaries, separated from the ventricles by choroid epithelial cells. Fluid filters ...
The choroid glomus or glomus choroideum, is an enlargement of the choroid plexus located in the atrium of each lateral ...
Tag: choroid. Posted on August 18, 2011. January 3, 2016. Notable Paper: Increased Expression of Multifunctional Serine ...
Tuberculosis of the Choroid: A Further Contribution Br Med J 1891; 2 :66 ... Tuberculosis of the Choroid: A Further Contribution. Br Med J 1891; 2 doi: https://doi.org/10.1136/bmj.2.1593.66 (Published 11 ...
I found out yesterday that my baby has fetal choroid plexus cysts. Can you please share with me if you had this finding on your ... I found out yesterday that my baby has fetal choroid plexus cysts. Can you please share with me if you had this finding on your ...
Since the choroid plexus can mediate interaction between peripheral and brain inflammation, our findings pinpoint the choroid ... In morphometric brain analysis, we serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from ... Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS. ... The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience. ...
choroid coats synonyms, choroid coats pronunciation, choroid coats translation, English dictionary definition of choroid coats ... choroid. (redirected from choroid coats). Also found in: Thesaurus, Medical, Encyclopedia. cho·roid. (kôr′oid′) or cho·ri·oid ( ... Choroid coats - definition of choroid coats by The Free Dictionary https://www.thefreedictionary.com/choroid+coats ... cho•roid. (ˈkɔr ɔɪd, ˈkoʊr-) adj. 1. Also, cho•roi′dal. like the chorion; membranous. ...
Choroid plexuses synonyms, Choroid plexuses pronunciation, Choroid plexuses translation, English dictionary definition of ... Choroid plexuses. n a multilobed vascular membrane, projecting into the cerebral ventricles, that secretes cerebrospinal fluid ... choroid plexus. (redirected from Choroid plexuses). Also found in: Thesaurus, Medical, Encyclopedia.. Related to Choroid ... Choroid plexuses - definition of Choroid plexuses by The Free Dictionary https://www.thefreedictionary.com/Choroid+plexuses ...
Superior choroid vein definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... A vein that follows the choroid plexus of the lateral ventricle and unites with the superior thalamostriate vein and the ...
Definition of choroid plexus of third ventricle. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms ... choroid plexus of third ventricle. Definition: the double row of vascular projections from the undersurface of the tela ...
Your doctor may find a choroid plexus cyst in your babys brain during a routine prenatal ultrasound. These cysts usually ... Picture of choroid plexus cyst. Share on Pinterest. A choroid plexus cyst, by itself, is a harmless collection of fluid that ... A choroid plexus cyst is a small, fluid-filled space that occurs in a gland in the brain called the choroid plexus. This gland ... Choroid plexus cyst and trisomy 18. Choroid plexus cysts are found in about a third of the time in fetuses with trisomy 18. ...
The choroid is of fundamental importance for nourishment... ... chapter describes the anatomy and the physiology of the choroid ... The choroid is of fundamental importance for nourishment of the retina so that all the alterations of the choroid lead to a ... Age-related changes of choroid are analyzed. Alterations have been described in the various layers of the choroid, which are ... choroid aging age-related macular disease choroidopaty hypertensive choroidopathy This is a preview of subscription content, ...
Choroid plexus papilloma is a rare, slow-growing, histologically benign intracranial neoplasm that is commonly located in the ... encoded search term (Imaging in Choroid Plexus Papilloma) and Imaging in Choroid Plexus Papilloma What to Read Next on Medscape ... The blood supply to choroid plexus papillomas is derived from the choroid plexus. An enlarged anterior choroidal artery ... including choroid plexus papillomas. Choroid plexus papillomas appear as well-marginated round or lobulated solid masses and ...
Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus ... tumors derived from choroid plexus epithelium that are seen predominantly in children. ... Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) ... Choroid plexus carcinomas (WHO grade III). Although choroid plexus papillomas typically look similar, one to another, choroid ...
Learn about choroid plexus tumor grades, features, causes, symptoms, who the tumors affect, how and where they form, and ... Where do choroid plexus tumors form?. Choroid plexus tumors arise from a structure in the brain called the choroid plexus. It ... What do choroid plexus tumors look like on an MRI?. Choroid plexus tumors usually appear in the ventricles of the brain. They ... Choroid plexus tumors occur in both children and adults, but are more common in children in the first year of life. Choroid ...
Choroid. Definition. The choroid is the layer of blood vessels and connective tissue between the white of the eye and retina ( ... Inflammation of the choroid is called choroiditis.. References. Dorlands Online Medical Dictionary. Available at: www.dorlands ...
The choroid plexus is comprised of a network of minute fringed capillaries, which secrete a liquid that is vital to the health ... Human Choroid Plexus. Human Choroid Plexus. The choroid plexus is comprised of a network of minute fringed capillaries, which ... The blood vessels of the choroid plexus protrude from the delicate envelope that covers the brain surface and continually leak ...
A choroid plexus cyst is a sac of fluid that grows in the brain of a fetus as it develops. Though a choroid plexus cyst is not ... Choroid plexus cysts are relatively common. About one percent of fetuses in the second and third trimester have a choroid ... A choroid plexus cyst is a cyst that can grow in the brain of a fetus during development. They are most commonly seen in the ... The choroid plexus of the brain is a small area near the lower middle portion of the organ that produces cerebral spinal fluid ...
I was wondering how many children had choroid plexus cysts. I was told it could indicate Downs Syndrome and would like to know ... I recently found out that the baby we are expecting has several choroid plexus cysts. We did not have amnio or AFP or triple ... Anyone have choroid plexus cysts? I recently found out that the baby we are expecting has several choroid plexus cysts. We did ... Adult with Choroid Plexus Cysts hoping to talk to others lovemyrinny. Brain & Nervous System Disorders. 12. 06-05-2007 08:39 AM ...
Yesterday I had my 20 week ultrasound and a CPC was found on my babys head. I am 23 years old and I know I have a low risk for trisomy 18 but im still
I had my anatomy scan and doctor said he saw a choroid plexus cyst and dilated kidney. Said both are common I am just curious ... Dilated kidney...and choroid plexus cysts. Anyone else been told that their baby boy has a dilated kidney? I had my anatomy ... Anyone else been told that their baby boy has a dilated kidney? I had my anatomy scan and doctor said he saw a choroid plexus ... scan and doctor said he saw a choroid plexus cyst and dilated kidney. Said both are common I am just curious if any of your ...
  • The choroid plexus produces most of the cerebrospinal fluid (CSF) of the central nervous system. (wikipedia.org)
  • The choroid plexus regulates the production and composition of cerebrospinal fluid (CSF), that provides the protective buoyancy for the brain. (wikipedia.org)
  • The choroid plexus is a small organ in the ventricles of the brain that makes cerebrospinal fluid (CSF). (cancer.ca)
  • In children, choroid plexus papillomas can be heterogeneous in appearance because of the accumulation of cerebrospinal fluid (CSF), blood, and blood products between the fronds and papillae. (medscape.com)
  • Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
  • Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma. (nih.gov)
  • Choroid plexus produces cerebrospinal fluid and is seen prominently in the posterior horn of the lateral ventricle in second-trimester ultrasounds. (jabfm.org)
  • In the 9th week of gestational age, the choroid plexus begins producing cerebrospinal fluid leading to expansion of the ventricular system. (jabfm.org)
  • Os pesquisadores encontraram que o plexo choroid actua como meio uma "rede de pesca" essa captações a proteína, chamou o beta-amyloid, e impede que se acumule no líquido cerebrospinal, que cerca e banha o cérebro e a medula espinal. (news-medical.net)
  • A pesquisa focalizou em como o plexo choroid funciona para limpar o beta-amyloid do líquido cerebrospinal. (news-medical.net)
  • Estes resultados parecem dizer-nos que que um plexo choroid saudável pode remover o beta-amyloid do líquido cerebrospinal, sugerindo um caminho novo para que o cérebro mantenha um balanço normal," Zheng disse. (news-medical.net)
  • These tumors arise from the choroid plexus, which lines the ventricles of the brain and produces cerebrospinal fluid. (abta.org)
  • Cerebrospinal fluid is continuously formed, mainly by secretion through the thin walls of the choroid plexuses. (thefreedictionary.com)
  • INTRODUCTION: The removal of the choroid plexus from the lateral ventricles was attempted by Dandy in the early 20th century but later discarded as complications arose and other methods of cerebrospinal fluid (CSF) diversion were introduced. (biomedsearch.com)
  • The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier. (hindawi.com)
  • In the mammalian brain the cerebrospinal fluid (CSF) is produced by the choroid plexus (CP), which not only regulates homeostasis in the central nervous system (CNS), but also participates in neurohumoral brain modulation as well as neuroimmune interaction [ 1 , 2 ]. (hindawi.com)
  • Choroid plexus papilloma (CPP) ia a non-cancerous (benign) tumor of the choroid plexus , a network of blood vessels in the brain which surrounds the ventricles and produces the fluid surrounding the brain and spinal cord (cerebrospinal fluid, or CSF). (nih.gov)
  • Because the choroid plexus is responsible for the generation of cerebrospinal fluid containing the intact form of prosaposin, the present study raises the possibility that Pro+0 mRNA is related to the intact form in the choroid plexus and that the alternatively spliced forms of mRNAs do not simply correspond to the precursor and intact forms of prosaposin. (springer.com)
  • Western blot was also performed in cerebrospinal fluid, serum and choroid plexus using anti-S-100β, antitransthyretin. (scirp.org)
  • Choroid plexus cyst- no nipt- panicking! (babycenter.com)
  • What Is a Choroid Plexus Cyst? (healthline.com)
  • A choroid plexus cyst is a small, fluid-filled space that occurs in a gland in the brain called the choroid plexus. (healthline.com)
  • A choroid plexus cyst is found in some fetuses and is usually picked up on an ultrasound during a woman's second trimester of pregnancy. (healthline.com)
  • For reasons that aren't fully understood, a choroid plexus cyst can form when fluid becomes trapped within the layers of cells of the choroid plexus. (healthline.com)
  • By around 25 weeks, a choroid plexus cyst can be visible on an ultrasound. (healthline.com)
  • When seen by itself, with all other systems developing normally, a choroid plexus cyst is what scientists call a normal variant. (healthline.com)
  • While many fetuses with trisomy 18 also have choroid cysts, only a small percentage of those with a choroid plexus cyst will also have trisomy 18. (healthline.com)
  • A fetus with trisomy 18 will have other abnormalities seen on an ultrasound besides the choroid plexus cyst. (healthline.com)
  • What does a choroid plexus cyst look like on an ultrasound? (healthline.com)
  • A choroid plexus cyst is an incidental finding discovered during a routine middle-of-pregnancy ultrasound. (healthline.com)
  • A choroid plexus cyst, by itself, is a harmless collection of fluid that can sometimes be seen in the choroid plexus portion of the brain. (healthline.com)
  • Even when an otherwise healthy child is born with a choroid plexus cyst, the baby will likely develop normally. (healthline.com)
  • Need some help understanding what a choroid plexus cyst is. (healthboards.com)
  • I had my anatomy scan and doctor said he saw a choroid plexus cyst and dilated kidney. (medhelp.org)
  • The first description of choroid plexus cyst (CPC) on antenatal sonogram appeared in the literature in 1984, 1 and soon after its association with trisomy 18 was described. (jabfm.org)
  • When a choroid plexus cyst is identified, the presence of structural malformations and other sonographic markers of aneuploidy should be assessed with a detailed fetal anatomic survey performed by an experienced provider. (contemporaryobgyn.net)
  • A choroid plexus cyst is a small fluid-filled structure within the choroid of the lateral ventricles of the fetal brain. (contemporaryobgyn.net)
  • What are the major clinical implications of an isolated choroid plexus cyst? (contemporaryobgyn.net)
  • If no other sonographic abnormalities are present, the choroid plexus cyst is considered isolated. (contemporaryobgyn.net)
  • A choroid plexus cyst is not considered a structural or functional brain abnormality. (contemporaryobgyn.net)
  • 2 The only association of some significance between an isolated choroid plexus cyst and a possible fetal problem is with trisomy 18. (contemporaryobgyn.net)
  • Based on a meta-analysis of 14 studies published before 2000, Ghidini et al suggested utilization of a composite (+) likelihood ratio of 7.09 (95% CI, 3.97-12.18).4 A large, single-center cohort study (N=1111 cases of isolated choroid plexus cyst) published in 2008 reported much lower risk. (contemporaryobgyn.net)
  • When an isolated choroid plexus cyst is detected, how is counseling different for women with a normal screen versus those whose screening indicates increased risk? (contemporaryobgyn.net)
  • Counseling for a woman after prenatal identification of a fetal choroid plexus cyst should be guided by the presence or absence of other sonographic markers or structural abnormalities, results of maternal screening for risk of trisomy 18 (if performed), and maternal age (Figure 2). (contemporaryobgyn.net)
  • In women who screen negative for trisomy 18 (either first- or second-trimester screening) and in whom no other fetal structural abnormalities are visualized on a detailed ultrasound, the finding of an isolated choroid plexus cyst does not require additional genetic testing. (contemporaryobgyn.net)
  • I had my 20 week ultrasound and it shows 1 small choroid plexus cyst on baby's brain. (whattoexpect.com)
  • A case of symptomatic cyst of the choroid plexus of a lateral ventricle in a child is reported. (ovid.com)
  • The epithelium of the choroid plexus is continuous with the ependymal cell layer (ventricular layer) that lines the ventricular system. (wikipedia.org)
  • The choroid is of fundamental importance for nourishment of the retina so that all the alterations of the choroid lead to a disfunction of the retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillary complex. (springer.com)
  • Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
  • To report the association of angioid streaks in patients with Pseudoxanthoma elasticum (PXE) with reticular pseudodrusen (RPD), thin choroid, and retinal pigment epithelium (RPE) atrophy using swept-source optical coherence tomography (SS-OCT) and short-wave autofluorescence (SWAF). (healio.com)
  • Choroid plexus carcinomas (CPCs) are rare, aggressive brain tumors arising from the cerebral ventricular epithelium and comprising 10-20% of intracranial tumors in children less than 1 year of age. (frontiersin.org)
  • The consist of fragments of delicate papillary structures with fibrovascular cores covered by a single layer of cytologically unremarkable choroid plexus epithelium. (radiopaedia.org)
  • Introduction: Choroid plexus carcinoma (CPC) is a rare central nervous system neoplasm derived from the choroid plexus epithelium. (omicsonline.org)
  • Both hindbrain roof plate epithelium (hRPe) and hindbrain choroid plexus epithelium (hCPe) produce morphogens and growth factors essential for proper hindbrain development. (biologists.org)
  • It is called a choroid plexus carcinoma. (cancer.ca)
  • The most common chemotherapy combination used to treat choroid plexus carcinoma is ifosfamide (Ifex), carboplatin (Paraplatin, Paraplatin AQ) and etoposide (Vepesid, VP-16). (cancer.ca)
  • There are three histopathological classifications of choroid plexus tumors: choroid plexus papilloma (CPP), atypical choroid plexus papilloma (ACP), and choroid plexus carcinoma (CPC). (springer.com)
  • Gross total resection improves overall survival in children with choroid plexus carcinoma. (springer.com)
  • Choroid plexus neoplasms: toward a distinction between carcinoma and papilloma using arterial spin-labeling. (springer.com)
  • Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
  • Grade III choroid plexus carcinoma are malignant (cancerous). (cancer.gov)
  • Choroid plexus carcinoma is the malignant (cancerous) form of the choroid plexus papilloma. (abta.org)
  • Choroid plexus carcinoma occurs primarily in children. (abta.org)
  • Sanford Research scientists are published in Nature Cell Biology for their work developing a model to explore therapies for a pediatric brain tumor known as choroid plexus carcinoma. (medicalxpress.com)
  • In January 2011, a 4 month old female presented with increased emesis and a bulging fontanelle and was diagnosed with Choroid Plexus Carcinoma (CPC) in the right ventricle with metastatic tumor cells present in the cerebral spinal fluid (CSF) and leptomeningeal carcinomatosis. (frontiersin.org)
  • Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. (aacrjournals.org)
  • In rare cases of choroid plexus papilloma or carcinoma, hydrocephalus is due to an overproduction of CSF. (ugent.be)
  • Eppinger MA, Berman CM, Halpern SL, Mazzola CA (2016) Prolonged Survival for Choroid Plexus Carcinoma with Oncocytic Changes: A Case Report. (omicsonline.org)
  • Choroid plexus carcinoma s ( CPC ) are rare, malignant neoplasms that represent 20-30% of CPTs in children [ 5 ]. (omicsonline.org)
  • Pathological and immunohistochemical studies of choroid plexus carcinoma of the dog. (thefreedictionary.com)
  • The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
  • however, morphologically the tumors appeared to be less differentiated than a choroid plexus papilloma and more differentiated than a choroid plexus carcinoma. (wikipedia.org)
  • The advent of CT scanning has resulted in improvement in the detection and characterization of all intracranial masses, including choroid plexus papillomas. (medscape.com)
  • Choroid plexus tumor epidemiology and outcomes: implications for surgical and radiotherapeutic management. (springer.com)
  • Although choroid plexus papillomas are readily apparent on most nonenhanced studies, the omission of enhanced imaging from the imaging protocol may result in incorrect conclusions about the tumor type and extent. (medscape.com)
  • In addition, misdiagnosis may result from an attempt to classify a choroid plexus tumor as benign or malignant solely on the basis of imaging characteristics. (medscape.com)
  • Choroid plexus papillomas may have limited parenchymal invasion, which makes the distinction of the benign tumor from its malignant counterpart difficult. (medscape.com)
  • The most frequent route of choroid plexus tumor spread is via seeding of the CSF. (medscape.com)
  • What are the symptoms of a choroid plexus tumor? (cancer.gov)
  • To improve choroid plexus tumor treatment through better understanding of the tumor biology and through increased knowledge about the benefit of specific treatment elements. (clinicaltrials.gov)
  • To compare the survival times after cyclophosphamide based treatment with the survival times after carboplatin based treatment in choroid plexus tumor patients. (clinicaltrials.gov)
  • Choroid plexus papilloma is a rare, benign (noncancerous) tumor. (abta.org)
  • Choroid plexus papilloma (CPP) is a rare type of brain tumor. (ahealthyme.com)
  • A CPP tumor grows in the choroid plexus. (ahealthyme.com)
  • New page: '''Choroid plexus tumor''' is a rare type of cancer that occurs in the choroid plexus of the brain . (wikidoc.org)
  • ICD-9 code 239.81 for Neoplasms of unspecified nature, retina and choroid is a medical classification as listed by WHO under the range -NEOPLASMS OF UNSPECIFIED NATURE (239). (aapc.com)
  • Edward C. W. Lee, Johannes F. de Boer, Mircea Mujat, Hyungsik Lim, and Seok H. Yun, "In vivo optical frequency domain imaging of human retina and choroid," Opt. (osapublishing.org)
  • This study will investigate use of high frequency (20 MHz) ultrasound for imaging of the retina and choroid in patients with age-related macular degeneration, a prime cause of blindness. (clinicaltrials.gov)
  • Specifically, high-resolution ultrasound will be used to generate images of the retina and choroid, including perfusion measurements using slow-flow methods developed by our research group. (clinicaltrials.gov)
  • This study aimed to evaluate if pDCs are present in naïve retina and choroid. (arvojournals.org)
  • Retina and choroid of naïve 6-8 week-old male wild-type C57BL/6 mice were digested via collagenase and DNase. (arvojournals.org)
  • The aim of this study was to identify the morphological features of the retina and choroid in Macaca fascicularis of different ages using multimodal imaging. (springer.com)
  • The aim of this study is to describe the microstructures of the retina and choroid in Macaca fascicularis and to compare the features of macaque eyes among different age groups. (springer.com)
  • B ) Specific insulin transcripts are differentially expressed in the choroid plexus and pancreatic islets. (jci.org)
  • C - E ) In the brain, all 3 transcript variants are more abundantly expressed in the choroid plexus than any other brain structure. (jci.org)
  • Children with choroid plexus tumours commonly have a buildup of CSF (hydrocephalus), which causes increased pressure on the brain and an increase in skull size. (cancer.ca)
  • Unlike the ependyma, the choroid plexus epithelial layer has tight junctions between the cells on the side facing the ventricle (apical surface). (wikipedia.org)
  • Choroid plexus epithelial cells actively transport sodium ions into the ventricles and water follows the resulting osmotic gradient. (wikipedia.org)
  • The choroid plexus consists of many capillaries, separated from the ventricles by choroid epithelial cells. (wikipedia.org)
  • The blood-CSF boundary at the choroid plexus is a membrane composed of epithelial cells and tight junctions that link them. (wikipedia.org)
  • By 14 days both dark and light choroid plexus epithelial cells are present. (nih.gov)
  • In contrast to the light choroid plexus epithelial cells, the dark cells have fine narrow microvilli. (nih.gov)
  • In agreement, expression of the proinflammatory cytokine TNF α is markedly increased in porcine choroid plexus epithelial cells after infection with the gram-positive bacterium Streptococcus suis [ 7 ]. (hindawi.com)
  • The choroid plexus (CP) is an epithelial and vascular structure in the ventricular system of the brain that is a critical part of the blood-brain barrier. (sigmaaldrich.com)
  • This work is the first to identify the zebrafish choroid plexus and to characterize its epithelial and vasculature integration. (sigmaaldrich.com)
  • NBC mRNA and protein were also present in epithelial cells of choroid plexus, ependyma, and meninges. (jneurosci.org)
  • The choroid plexus is located within the cerebral ventricles and is made of epithelial cells , loose connective tissue ( tela choroidea ), and permeable capillaries. (radiopaedia.org)
  • Choroid plexus tumors (CPTs) are rare, intraventricular neoplasms that originate from the epithelial cells of the choroid plexus [ 1 - 4 ]. (omicsonline.org)
  • We used flow cytometry and the UIC2 monoclonal antibody against Pgp, to demonstrate the presence of Pgp in the epithelial cell fraction isolated from the sheep choroid plexuses (CPEC). (nel.edu)
  • The choroid plexus (ChP) is a highly vascularized tissue found in the brain ventricles, with an apical epithelial cell layer surrounding fenestrated capillaries. (jci.org)
  • Recurrent choroid plexus carcinomas are tumours that have come back after treatment. (cancer.ca)
  • Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. (springer.com)
  • Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
  • Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
  • Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
  • Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
  • Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
  • Choroid plexus carcinomas may also have some swelling around them, which can be seen during an MRI. (cancer.gov)
  • Rarely, certain gene changes that can be passed down through families have been linked to a higher chance of developing choroid plexus carcinomas. (cancer.gov)
  • Atypical choroid plexus papillomas are considered grade II, and chroid plexus carcinomas are typically grade III tumors. (abta.org)
  • Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. (frontiersin.org)
  • Typical choroid plexus carcinomas (CPCs) show variable morphology with a syncytial or solid arrangement. (thefreedictionary.com)
  • A grade II tumour is called an atypical choroid plexus papilloma. (cancer.ca)
  • Grade II atypical choroid plexus papilloma are mid-grade tumors. (cancer.gov)
  • the double row of vascular projections from the undersurface of the tela choroidea, where it roofs over the third ventricle. (drugs.com)
  • The first section of this chapter describes the anatomy and the physiology of the choroid and the vascular pattern of the choroidal vessels. (springer.com)
  • Gyrate atrophy is a rare hereditary disease of the eye's retina (the layer of light-sensitive tissue that lines the inside of the eyeball) and choroid (a vascular layer of tissue behind the retina). (clinicaltrials.gov)
  • Corrosion casts of the complete vascular network of the choroid plexus of the lateral ventricle in the cat brain were studied in SEM using the injection-replication method. (biomedsearch.com)
  • The vascular organization of the choroid plexus of the lateral ventricle in cat is compared to that of the corresponding plexuses in other mammals. (biomedsearch.com)
  • Historically, patients with CPH were treated by shunt procedures or by microsurgical removal of the choroid plexus, which is associated with a high complication rate. (ugent.be)
  • Retinoic acid receptor (RAR) signaling is required for morphogenesis of the ventral optic cup and closure of the choroid fissure, but the mechanisms by which this pathway regulates ventral eye development remain controversial and poorly understood. (pnas.org)
  • The choroid plexus or plica choroidea, is a plexus of cells that arises from the tela choroidea in each of the ventricles of the brain. (wikipedia.org)
  • I found out yesterday that my baby has fetal choroid plexus cysts. (babycenter.com)
  • A screening ultrasonogram performed at 16 weeks of gestation showed bilateral choroid plexus cysts approximately 5 mm in diameter. (jabfm.org)
  • Bilateral choroid plexus cysts in the lateral ventricles. (ajnr.org)
  • Choroid plexus tumours start in the part of the brain called the choroid plexus. (cancer.ca)
  • Choroid plexus tumors arise from a structure in the brain called the choroid plexus. (cancer.gov)
  • These tumors arise from brain tissue called the "choroid plexus. (abta.org)
  • The majority of CPTs are benign choroid plexus papillomas, which exhibit excellent prognosis [ 7 ]. (omicsonline.org)
  • Research shows that there is an association between choroid plexus cysts and aneuploidy. (jabfm.org)
  • Counseling should include a discussion of the association between choroid plexus cysts and trisomy 18, and diagnostic testing should be offered. (contemporaryobgyn.net)
  • Choroid plexus cysts are found in about a third of the time in fetuses with trisomy 18. (healthline.com)
  • 20 ,21 Despite the low incidence, CPC has clinical implications for aneuploidy because of an association of choroid plexus with trisomy 18 2 ,5-12 ,22 and trisomy 21. (jabfm.org)
  • 13 Approximately three fourths of abnormal fetal karyotypes associated with choroid plexus cysts are trisomy 18 and one fourth are trisomy 21. (jabfm.org)
  • Choroid plexus cysts are present in 30% to 50% of fetuses with trisomy 18. (contemporaryobgyn.net)
  • Studies from the 1990s reported that the risk of trisomy 18 with isolated choroid plexus cysts was approximately 1 in 200 to 1 in 400. (contemporaryobgyn.net)
  • 7 Given the considerable improvements in imaging technology and aneuploidy screening in recent years, the risk of trisomy 18 in the setting of isolated choroid plexus cysts is now believed to be much lower. (contemporaryobgyn.net)
  • Ultrasound characteristics of choroid plexus cysts (size, complexity, laterality, and persistence) should not be used to further modify risk because these factors do not significantly impact the likelihood of trisomy 18. (contemporaryobgyn.net)
  • Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature. (springer.com)
  • as, the choroid plexuses of the ventricles of the brain, and the choroid coat of the eyeball. (everything2.com)
  • At 11 to 14 postmenstrual weeks, the US image of the brain is dominated by the two relatively prominent lateral ventricles, which are filled with the choroid plexuses (FIGORE 3, page 41). (thefreedictionary.com)
  • Accumulation of benzylpenicillin in choroid plexuses preloaded with HCO3-, SCN- or benzylpenicillin also was stimulated compared with the accumulation in unpreloaded choroid plexuses. (aspetjournals.org)
  • The choroid plexuses also form the blood-CSF barrier alongside arachnoid and arachnoid villi 2 . (radiopaedia.org)
  • The objective of the present work was to assess the presence of P-glycoprotein (Pgp), which could be responsible for this transport at the level of the choroid plexuses (CP). (nel.edu)
  • Malignant progression in choroid plexus papillomas. (springer.com)
  • Borlongan CV, Skinner SJ, Geaney M, Vasconcellos AV, Elliott RB, Emerich DF (2004) Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke. (springer.com)
  • Gyrate atrophy of the choroid and retina, which is often shortened to gyrate atrophy, is an inherited disorder characterized by progressive vision loss. (medlineplus.gov)
  • Gyrate atrophy of the choroid and retina (GA) is a rare autosomal recessive chorioretinal degeneration characterized by myopia, cataract, varying degrees of night blindness, and progressive constriction of visual fields associated with chorioretinal atrophy resulting in blindness. (clinicaltrials.gov)
  • ICD-9 code 363.42 for Diffuse secondary atrophy of choroid is a medical classification as listed by WHO under the range -DISORDERS OF THE EYE AND ADNEXA (360-379). (aapc.com)
  • Angioid streaks in PXE are associated with RPD, thin choroid, and RPE atrophy. (healio.com)
  • Gyrate atrophy of the choroid and retina is an inherited disorder of protein metabolism characterized by progressive vision loss. (nih.gov)
  • While most people with gyrate atrophy of the choroid and retina have no symptoms other than vision loss, neonatal hyperammonemia (excess ammonia in the blood in the newborn period), neurological abnormalities, intellectual disability , peripheral nerve problems, and muscle weakness may occur. (nih.gov)
  • thus the choroid plexus acts as a blood-CSF barrier. (wikipedia.org)
  • Development of the choroid plexus and blood-CSF barrier. (radiopaedia.org)
  • Many children with choroid plexus tumours are treated in a clinical trial. (cancer.ca)
  • The choroid plexus consists of modified ependymal cells surrounding a core of capillaries and loose connective tissue. (wikipedia.org)
  • The choroid is the middle layer of the eye that contains blood vessels and connective tissue that supplies nutrients to the inner portion of the eye. (medlineplus.gov)
  • Choroid plexus tumors (CPT) are rare tumors of the neuroepithelial tissue of the brain that are most common in young children. (springer.com)
  • which is the specialized light-sensitive tissue that lines the back of the eye, and in a nearby tissue layer called the choroid. (medlineplus.gov)
  • The choroid plexus is made of connective tissue, blood vessels, and the ependymal cells. (ahealthyme.com)
  • Choroid plexus cells are involved with ependymal cells in the production of CSF. (labce.com)
  • A choroid plexus is in part of the roof of the fourth ventricle. (wikipedia.org)
  • Suprasellar seeding of a benign choroid plexus papilloma of the fourth ventricle with local recurrence. (springer.com)
  • This parasympathetic ganglion contains 2 distinct types of neurons: choroid neurons, which project to vasculature in the eye's choroid layer and use somatostatin as a co-transmitter with ACh, and ciliary neurons, which innervate the ciliary body and iris and use ACh but no known peptide co-transmitter. (jneurosci.org)
  • in children (mean age, 5.2 yr), choroid plexus papillomas appear as large tumors and account for 1.5-6.4% of intracranial neoplasms. (medscape.com)
  • The overall annual incidence of choroid plexus neoplasms for all ages is 0.3 cases per million. (medscape.com)
  • [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
  • The vast majority of choroid plexus neoplasms arise within the ventricles. (medscape.com)
  • The third ventricle is the least common intraventricular location for choroid plexus neoplasms, irrespective of patient age. (medscape.com)
  • Although previous studies have implicated neural crest-derived periocular mesenchyme (POM) as the critical target of RA action in the eye, we show here that RAR signaling regulates choroid fissure closure in zebrafish by acting on both the ventral optic cup and the POM. (pnas.org)
  • However, very little is known about the cellular mechanisms that regulate choroid fissure closure. (frontiersin.org)
  • Concerning melanoma of the choroid with report of one case of this character and of another exhibiting a pigmented sarcoma of the choroid early in its development. (pubmedcentralcanada.ca)
  • A uveal melanoma that arises from the choroid. (mycancergenome.org)
  • There are 2 clinical trials for choroid melanoma, of which 1 is open and 1 is completed or closed. (mycancergenome.org)
  • Of the trials that contain choroid melanoma as an inclusion criterion, 1 is phase 1/phase 2 (0 open) and 1 is phase 2 (1 open). (mycancergenome.org)
  • Au-011 is the most common intervention in choroid melanoma clinical trials. (mycancergenome.org)
  • Choroid plexus hyperplasia (CPH) is a distinct clinicopathological entity in which the enlarged choroid plexus produces large amounts of CSF. (ugent.be)
  • Choroid plexus tumors usually appear in the ventricles of the brain. (cancer.gov)
  • Olver JM (1990) Functional anatomy of the choroidal circulation: methyl methacrylate casting of human choroid. (springer.com)
  • This article provides an overview of choroidal pathology and the application of contemporary imaging techniques used to view the choroid in vivo. (aop.org.uk)
  • Further, to assess if retinal/choroidal pDCs express Toll-like Receptor (TLR)-7 and TLR-9, GFP + cells were isolated from the choroid and retina, and splenic macrophages were sorted as controls via IF staining with F4/80 (macrophage marker) using flow cytometry. (arvojournals.org)
  • While optical techniques can reveal much about the structure of the retina, ultrasound allows imaging of the choroid and deeper tissues. (clinicaltrials.gov)
  • What is the prognosis of choroid plexus tumors? (cancer.gov)
  • The relative 5-year survival rate for choroid plexus tumors is 63.9% but know that many factors can affect prognosis. (cancer.gov)
  • The prognosis for choroid plexus papilloma (CPP) is determined mainly by how completely the lesion is removed during surgery. (nih.gov)
  • Chorioretinitis is an inflammation of the choroid, which is a lining of the retina deep in the eye. (uvahealth.com)
  • Clinical outcome of adult choroid plexus tumors: retrospective analysis of a single institute. (springer.com)
  • TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors. (springer.com)
  • The goal of this clinical research study is to compare carboplatin to cyclophosphamide when given with etoposide, vincristine, and radiation therapy in the treatment of choroid plexus tumors. (clinicaltrials.gov)