Choroid Plexus: A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.Choroid: The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.Choroid Plexus Neoplasms: Benign or malignant tumors which arise from the choroid plexus of the ventricles of the brain. Papillomas (see PAPILLOMA, CHOROID PLEXUS) and carcinomas are the most common histologic subtypes, and tend to seed throughout the ventricular and subarachnoid spaces. Clinical features include headaches, ataxia and alterations of consciousness, primarily resulting from associated HYDROCEPHALUS. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072; J Neurosurg 1998 Mar;88(3):521-8)Papilloma, Choroid Plexus: A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)Choroid Neoplasms: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).Choroid Diseases: Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.Cerebral Ventricle Neoplasms: Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Uvea: The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)Ependyma: A thin membrane that lines the CEREBRAL VENTRICLES and the central canal of the SPINAL CORD.Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Sclera: The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.Ornithine-Oxo-Acid Transaminase: A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-amino acid from L-ornithine and a 2-keto-acid. EC 2.6.1.13.Eye: The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.Meninges: The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.Ciliary Body: A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Retinal Pigment Epithelium: The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Fluorescein Angiography: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Cefadroxil: Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.Choroidal Neovascularization: A pathological process consisting of the formation of new blood vessels in the CHOROID.Cerebral Ventricles: Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).Hydrocephalus: Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Iris: The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Fundus Oculi: The concave interior of the eye, consisting of the retina, the choroid, the sclera, the optic disk, and blood vessels, seen by means of the ophthalmoscope. (Cline et al., Dictionary of Visual Science, 4th ed)Vitreous Body: The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.Fourth Ventricle: An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.Lateral Ventricles: Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Retinal Detachment: Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).Arachnoid: A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.Retinal Vessels: The blood vessels which supply and drain the RETINA.Sturge-Weber Syndrome: A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.Ganglia, Parasympathetic: Ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen.Coloboma: Congenital anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Fluorescein: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.Visna-maedi virus: A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), that can cause chronic pneumonia (maedi), mastitis, arthritis, and encephalomyelitis (visna) in sheep. Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). Visna is a demyelinating leukoencephalomyelitis of sheep which is similar to but not the same as SCRAPIE.Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Corrosion Casting: A tissue preparation technique that involves the injecting of plastic (acrylates) into blood vessels or other hollow viscera and treating the tissue with a caustic substance. This results in a negative copy or a solid replica of the enclosed space of the tissue that is ready for viewing under a scanning electron microscope.Myopia: A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.Chorion: The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.

Microvascular loops and networks as prognostic indicators in choroidal and ciliary body melanomas. (1/1300)

BACKGROUND: Malignant melanoma of the ciliary body and choroid of the eye is a tumor that disseminates frequently, and 50% of the diagnosed patients die within 10 years. We investigated the hypothesis that, by histopathologic analysis of the arrangement of microvessels (i.e., small blood vessels) in loops and networks, we might be able to differentiate better those patients with a favorable prognosis from those with a poor prognosis. METHODS: We conducted a population-based, retrospective cohort study of melanoma-specific and all-cause mortality for 167 consecutive patients who had an eye surgically removed because of malignant choroidal or ciliary body melanoma during the period from 1972 through 1981. Microvascular loops and networks were evaluated independently by two pathologists who were unaware of patient outcome. RESULTS: Microvascular patterns could be assessed in 134 (80%) of 167 melanoma specimens. The 10-year probability of melanoma-specific survival was worse if microvascular loops (0.45 versus 0.83; two-sided P<.0001) and networks (0.41 versus 0.72, two-sided P<.0001) were present. In multivariate Cox regression analysis of melanoma-specific survival, the hazard ratios were 1.66 (95% confidence interval [CI] = 1.19-2.30) for the presence of loops and networks as a combined three-category variable, 2.36 (95% CI = 1.37-4.05) for the presence of epithelioid cells, 1.11 (95% CI = 1.03-1.19) for the largest basal tumor diameter (evaluated as a continuous variable), and 2.14 (95% CI = 1.25-3.67) for ciliary body involvement. CONCLUSIONS: Patients with malignant uveal melanoma who have a favorable prognosis can be distinguished from those with a poor prognosis by histopathologic analysis of microvascular patterns in uveal melanoma tumor specimens.  (+info)

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age. (2/1300)

PURPOSE: To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes and choroid in vivo. METHODS: Human Bruch's membrane samples were isolated from the retinal pigment epithelium (RPE) and choroid and subjected to reversed-phase high-performance liquid chromatography to determine pentosidine content. A polyclonal anti-pentosidine antibody and a monoclonal antibody specific for carboxymethyllysine were used to localize AGEs in 20-month-old nondiabetic, 82-year-old nondiabetic, and 82-year-old diabetic globes. RESULTS: Human Bruch's membranes (n = 20) showed a linear age-dependent increase in pentosidine that reached approximately 0.17 millimoles pentosidine per mole hydroxyproline in late life (r = 0.896; P < 0.001). Immunohistochemical evaluation showed evidence of pentosidine in Bruch's membrane, choroidal extracellular matrix, and vessel walls in the 82-year-old nondiabetic and diabetic globes. A similar staining pattern was found with the anti-CML antibody. Basal laminar deposits and drusen stained with both antibodies in the elderly nondiabetic eye. In contrast, neither antibody stained the 20-month-old tissue. CONCLUSIONS: We provide biochemical and immunohistochemical evidence for the formation of pentosidine and CML structures in human Bruch's membrane and choroid with age. These changes could promote aging of the RPE-Bruch's membrane-choroid complex.  (+info)

Idiopathic central serous chorioretinopathy. (3/1300)

Idiopathic central serous chorioretinopathy (ICSC) is usually seen in young males with Type A personality. Clinical evaluation of the macula with fundoscopy and biomicroscopy, coupled with fluorescein angiography establishes the diagnosis. Indocyanine green angiographic studies have reinformed that the basic pathology lies in choriocapillaries and retinal pigment epithelium. Most of the ICSC resolve completely in four months, and some of them could resolve early with direct photocoagulation of the leaking site. Oral steroids have no role, and could even cause an adverse reaction.  (+info)

Clinical characteristics of CHARGE syndrome. (4/1300)

CHARGE syndrome, first described by Pagon, was named for its six major clinical features. They are: coloboma of the eye, heart defects, atresia of the choanae, retarded growth and development including CNS anomalies, genital hypoplasia and/or urinary tract anomalies, and ear anomalies and/or hearing loss. We experienced three cases of CHARGE syndrome who displayed ocular coloboma, heart defects, retarded growth and development, and external ear anomalies, and we also review the previously reported literature concerning CHARGE syndrome.  (+info)

Effects of bicarbonate ion on chick retinal pigment epithelium: membrane potentials and light-evoked responses. (5/1300)

The purpose of this study was to determine how changes in [HCO3-] alter the electrical properties of the retinal pigment epithelium (RPE). Experiments were conducted on the isolated chick retina-RPE-choroid preparation. The chamber holding the preparation allowed independent perfusion of the retinal and the choroidal surfaces. The light-evoked trans-tissue potential (TTP), the trans-epithelial potential (TEP), the trans-retinal potentials, and the intracellularly-recorded apical and basal membrane potentials were studied. Increasing the [HCO3-]0 in the choroidal bath from 25 to 40 mEq/1 led to an increase in the TTP and TEP. The same change in the retinal bath decreased the TTP because of a biphasic change of the RPE membrane potentials. There was also an increase in the amplitudes of the TEP, the c-wave and the slow PIII. The light-evoked subretinal K+ decrease was greater which is consistent with an increase in the photoreceptor light response. These observations indicated that the decrease of TTP resulted from a basal membrane hyperpolarization followed by an apical membrane depolarization induced by an increase in retinal [HCO3-]0. The relationship of these potential changes to the human bicarbonate responses is discussed.  (+info)

Dendritic cells and macrophages in the uveal tract of the normal mouse eye. (6/1300)

BACKGROUND/AIMS: Dendritic cells (DC) and macrophages are components of the immune cell populations in the uveal tract whose density, distribution, turnover, and function may play a role in the maintenance of immunological homeostasis in the eye. Little is known of these cells in the mouse eye despite this being the predominant experimental model in many studies of ocular immune responses and immunoinflammatory mediated eye diseases. The aim of the present study was to obtain further immunophenotypic data on resident tissue macrophages and DC populations in the mouse uveal tract. METHODS: Pieces of iris, ciliary body, and choroid dissected from perfusion fixed BALB/c mice were incubated whole in a variety of anti-macrophage and DC monoclonal antibodies (mAbs). Labelled cells were visualised using either single or double immunoperoxidase techniques. RESULTS: Quantitative analysis and double immunolabelling revealed that 80% of F4/80(+) cells (a mAb that recognises both DC and macrophages) in the iris are macrophages (SER4(+)). The iris contained a network of Ia+ cells (412 (SD 130) cells/mm2) of which two thirds appear to be DC. A similar pattern was observed in the ciliary body and choroid. Only a few DC in the uveal tract were very weakly reactive for mAbs which recognise B7-1 (CD80), B7-2 (CD86), beta2 integrin (mAb N418), and multivesicular bodies associated with antigen presentation (mAb M342). CONCLUSIONS: The present study reveals that the mouse uveal tract, like the rat, contains rich networks of DC and resident tissue macrophages. The networks of resident tissue macrophages in the mouse uveal tract closely resemble similar networks in non-ocular tissues. The phenotype of uveal tract DC suggests they are in the "immature" phase of their life cycle, similar to Langerhans cells of the skin, thus implying their role in situ within the eye is antigen capture and not antigen presentation.  (+info)

Zinc deficiency and oxidative stress in the retina of pigmented rats. (7/1300)

PURPOSE: To determine the effect of moderate zinc deficiency on antioxidant defenses and measures of oxidative stress in the retina and retinal pigment epithelium (RPE) of Brown Norway Rats. METHODS: Twenty-four rats were housed individually and divided into three groups of 8 rats each. Group 1 was fed ad libitum a semipurified control diet formulated to contain 50 parts per million [ppm] total zinc; group 2 was fed ad libitum an identical diet but containing 5 ppm total zinc; and group 3 was pair-fed the control diet but restricted in amount to that consumed by group 2. Food intake was measured daily and the rats weighed weekly. After 6 weeks, the rats were killed and the following measurements were made: serum zinc, serum alkaline phosphatase, retinal zinc, RPE-choroid zinc, RPE-choroid catalase, liver metallothionein (MT), retinal MT, RPE-choroid MT, retinal catalase, and retinal thiobarbituric reactive substances (TBARS). RESULTS: The following showed statistically significant differences between groups 2 and 3, respectively: serum Zn (1216 micro/l versus 1555 microg/l, P < or = 0.01), serum alkaline phosphatase (3.75 U/mg versus 5.10 U/mg, P < or = 0.05), liver MT (4.3 microg/mg protein versus 16.7 microg/mg, P < or = 0.0001), RPE-choroid MT (1.3 microg/mg protein versus 2.2 microg/mg, P < or = 0.02), retinal MT (0.85 microg/mg protein versus 2.8 microg/mg, P < or = 0.05), and retinal TBARS (6.2 nM/mg protein versus 2.2 nM/mg, P < or = 0.05). CONCLUSIONS: The results show that retinal MT and RPE MT concentrations are very sensitive to intake of dietary zinc. The increase in retinal TBARS in group 2 indicates that moderate zinc deficiency increases oxidative stress to the retina. The results also suggest that MT is protective against lipid peroxidation of retinal membranes.  (+info)

Structural specializations of the eye in the vizcacha (Lagostomus maximus maximus). (8/1300)

Vizcachas (Lagostomus maximus maximus, Chinchillidae) are nocturnal rodents living in burrows in many regions of Argentina, Bolivia, and Chile. We have studied the eye of the vizcacha using several light and electron microscopic procedures, with the purpose of understanding the role of vision in the behavior of this species. Our observations demonstrated an avascular, rod-rich retina, with a specialized region spanning through most of the equator of the eye. In this central band, all neural retinal layers exhibited a high cell density, whereas the photoreceptor layer was characterized by the presence of very long rods. In addition, the central region was associated with a distinct pigmentation pattern, including scarce granulation of the pigment epithelium, low pigmentation of the choroid, and the selective attachment of suprachoroidal cells to the inner scleral surface. These central modifications probably form the structural basis of a reflecting tapetum. The eye of the vizcacha received both long and short ciliary vessels, and a specialized cilio-sclero-choroidal vascular network appeared at the equatorial region. Our findings suggest that the equatorial region of the eye of the vizcacha could be a highly sensitive light detector related to foraging behaviors during crepuscular or nocturnal hours.  (+info)

A total of 56 eyes had choroidal vascular hyperpermeability, of which 49 eyes (87.5%) had enhanced-depth imaging OCT images available. Mean subfoveal choroidal thickness was 389.5 ± 121.1 μm in these 49 eyes. Subfoveal choroidal thickness was less than 200 μm in four eyes (one eye with typical exudative AMD, three eyes with PCV), between 200 and 400 μm in 21 eyes (4 eyes with typical exudative AMD, 17 eyes with PCVs), and greater than 400 μm in 24 eyes (4 eyes with typical exudative AMD, 20 eyes with PCVs, Fig. 2A). Of the 168 eyes with punctate hyperfluorescent spots, enhanced-depth imaging OCT images were available in 154 eyes (91.7%). Mean subfoveal choroidal thickness was 318.6 ± 127.4 μm in these 154 eyes. Subfoveal choroidal thickness was less than 200 μm in 30 eyes (10 eyes with typical exudative AMD, 16 eyes with PCV, 3 eyes with RAP, 1 eye with myopic CNV), between 200 and 400 μm in 79 eyes (16 eyes with typical exudative AMD, 59 eyes with PCV, 1 eye with RAP, 3 eyes with ...
The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregnant women using spectral-domain optical coherence tomography (OCT). This cross-sectional study included 122 eyes of 61 women, divided into two groups: 27 healthy pregnant women in the third trimester and 34 age-matched healthy non-pregnant women. Choroidal thickness was measured using Enhanced Depth Imaging OCT at ten different locations: at the fovea and every 500 µm from the fovea up to 2500 µm temporally and up to 2000 µm nasally. There were no significant differences in the ten measurements of choroidal thickness comparing both groups. Mean subfoveal choroidal thickness was 304.1 + 9.6 µm in the control group and 318.1 + 15.6 µm in the pregnant women group (p = 0.446). There was also no statistically significant association between gestational age and choroidal thickness measurements in the
Mean follow-up was 1.6 ± 0.76 years, without difference between the two study groups (p=0.6766). Choroid was significantly thicker in the bilateral GA group eyes compared to the fellow eye CNV group eyes at baseline (mean choroidal thickness: 170.5 ± 78.5 μm vs 129.1 ± 36.1 μm, p = 0.0371 ) and during follow-up (mean choroidal thickness: 173.2 ± 86.1 μm vs 123 ± 32.1 μm, p = 0.0340) . Mean choroidal thickness significantly decreased during follow-up only in the fellow eye CNV group (p=0.0276 in the fellow eye CNV group vs p= 0.4137 in the bilateral GA group). Mean GA area was not significantly different in the two groups neither at baseline nor at follow-up (p=0.4118 in B-FAF and p= 0.6806 in NIR-FAF at baseline, p= 0.5734 in B-FAF and p=0.8945 in NIR-FAF at follow-up) even if mean GA area significantly increased in both groups during follow-up. Mean retinal sensitivity significantly decreased during follow-up only in the bilateral GA group (p= 0.0405 in the bilateral GA group vs ...
Results The mean choroidal thickness at the fovea prior to smoking was 301.1±63.1 μm, which decreased to 284.2±56.7 μm at 1 h and 270.8±80.0 μm at 3 h following smoking (p=0.001). The mean choroidal thickness was significantly decreased following smoking at all five extrafoveal points. The difference in choroidal thickness was not statistically significant at 1 and 3 h of smoking at all six points. In the control group, the mean baseline choroidal thickness at the fovea was 270.6±57.9 μm, which was 272.5±52.4 μm at 1 h and 273.8±57.4 μm at 3 h (p=0.816).. ...
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Changes in axial length and choroidal thickness after intraocular pressure reduction resulting from trabeculectomy Shinichi Usui,1,2 Yasushi Ikuno,2 Sato Uematsu,1 Yuko Morimoto,1 Yoshiaki Yasuno,3 Yasumasa Otori11National Hospital Organization, Osaka National Hospital, Osaka, Japan; 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 3Computational Optics Group, University of Tsukuba, Tsukuba, JapanPurpose: To evaluate changes in axial length and choroidal thickness after trabeculectomy.Patients and methods: Fourteen patients under 80 years of age with glaucoma, were enrolled. The choroid was imaged using prototypical high-penetration optic coherence tomography (OCT) and the thickness was measured. Axial length, choroidal thickness, and intraocular pressure (IOP) were measured bilaterally at 3 pm 1 day before and 6 days after trabeculectomy. The choroidal thickness was measured at the fovea and four other locations (2 mm superior, temporal, inferior, and nasal to
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3D swept-source OCT detected FCE in 9 eyes (7.8 %). The 3D scanning protocol ‎allowed for detection of small extrafoveal excavations and the 3D segmentation method ‎coupled with en-face scans allowed for clear visualization of the morphology of the ‎excavations. In 5 eyes with FCE, unusual choroidal tissue was detected beneath the ‎FCE, bridging between the bottom of FCE and the outer choroidal boundary. In addition, ‎three of those five eyes showed a suprachoroidal space below the FCE, as if the outer ‎boundary of choroid is pulled inward by this bridging tissue. FCE was often seen within ‎the leakage point and choroidal hyperpermeability. Eyes with FCE were more myopic ‎‎(-4.42 ± 2.92 diopters), and the subfoveal choroidal thickness was significantly thinner ‎‎(301.3 ± 60.1 µm), as compared to control CSC eyes (P = .001 and .036 respectively ...
Results Of the 462 recruited participants, 273 had no diabetes (mean age was 60.1±6.8 years), 100 had diabetes but no DR (61.8±7.4 years) and 89 had DR (62.4±6.0 years). In multiple regression analysis, after accounting for relevant confounders, compared with those without diabetes, participants with diabetes had significantly thinner mean choroidal thickness (CT; mean difference (MD)=−25.19 µm, p=0.001), smaller choroidal volume (MD=−0.23 mm3, p=0.003), more inflection points (MD=1.78, p,0.001) and lesser choroidal vascular area within the foveal (MD=−0.024 mm2, p=0.001) and macular (MD=−0.095 mm2, p,0.001) regions. Among the diabetic group, subjects with DR had significantly thicker mean CT (MD=25.91 µm, p=0.001), greater choroidal volume (MD=0.24 mm3, p=0.009), lesser inflection points (MD=−0.478, p=0.045) and greater choroidal vascular area at foveal (MD=0.016 mm2, p=0.019) and macular (MD=0.057 mm2, p=0.016) regions, compared with those without DR. ...
Advances in the discovery of the causes of monogenic retinal disorders, combined with technologies for the delivery of DNA to the retina, offer enormous opportunities for the treatment of previously untreatable blinding diseases. However, for gene augmentation to be most effective, vectors that have the correct cell-type specificity are needed. While animal models are very useful, they often exhibit differences in retinal cell surface receptors compared to human retina. In this study, we evaluated the use of an ex vivo organotypic explant system to test the transduction efficiency and tropism of 7 different adeno-associated viral type 2 (AAV2) serotypes in human retina and retinal pigment epithelium-choroid: AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9, all driving expression of GFP under control of the cytomegalovirus promoter. After 7 days in culture, we found that AAV2/4 and AAV2/5 are particularly efficient at transducing photoreceptor cells and that AAV2/5 is highly specific ...
Advances in the discovery of the causes of monogenic retinal disorders, combined with technologies for the delivery of DNA to the retina, offer enormous opportunities for the treatment of previously untreatable blinding diseases. However, for gene augmentation to be most effective, vectors that have the correct cell-type specificity are needed. While animal models are very useful, they often exhibit differences in retinal cell surface receptors compared to human retina. In this study, we evaluated the use of an ex vivo organotypic explant system to test the transduction efficiency and tropism of 7 different adeno-associated viral type 2 (AAV2) serotypes in human retina and retinal pigment epithelium-choroid: AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9, all driving expression of GFP under control of the cytomegalovirus promoter ...
This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by Haibo Wang, Yanchao Jiang and M. Elizabeth Hartnett. Thy-1 regulates VEGF-induced choroidal endothelial cell migration Dept of Ophthalmology, John A. Moran Eye Center, The University of Utah-Salt Lake City. Purpose: Choroidal endothelial cell (CEC) activation and migration […]. ...
Retrospective study of pediatric patients with SCD followed in the medical retina unit of Jules-Gonin Eye Hospital .The study group was compared to a control group matched for age, sex and ethnicity. Retinal thinning, macular splaying (foveal diameter), foveal depth and subfoveal choroidal thickness were measured using OCT (Heidelberg Engineering, Germany ...
VEGF-PEDF balance is altered in RPE/choroids from mice exposed to HQ.(A) VEGF and (B) PEDF mRNA expression in response to HQ-induced oxidative injury. Total RNA
Three aims are proposed to study the chorioretinal complex (choroid, choriocapillaris, Bruchs membrane, retinal pigment epithelium, photoreceptors) in age-rela...
TY - JOUR. T1 - Effects of timolol and betaxolol on choroidal blood flow in the rabbit. AU - Kiel, J. W.. AU - Patel, P.. PY - 1998/11. Y1 - 1998/11. N2 - This study evaluated the effects of the topical β-adrenergic antagonist betaxolol and the non-selective β-adrenergic antagonist timolol on the choroidal pressure-flow relationship. Pentobarbital-anesthetized rabbits were instrumented with hydraulic occluders on the aorta and inferior vena cava to control MAP an ear artery cannula to measure mean arterial pressure (MAP), and two vitreous cannulas to control and measure intraocular pressure (IOP). Choroidal blood flow was measured by laser Doppler flowmetry with the fiber- optic probe tip positioned over the posterior pole. Choroidal pressure-flow curves were obtained before and 30 min after topical application of 0.1 ml of betaxolol (Betoptic, 0.5%, n = 10), timolol (Timoptic, 0.5%, n = 10) or saline (n = 8) by varying the MAP without controlling the IOP and by raising IOP while holding the ...
This study aimed to analyze the choroidal characteristics in eyes with polypoidal choroidal vasculopathy (PCV, affected eyes) and unaffected fellow eyes, a
PURPOSE To compare the 12-month real-world visual and disease activity outcomes of eyes with polypoidal choroidal vasculopathy (PCV) treated with a combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) injections (combination group) versus those eyes treated with anti-VEGF monotherapy alone with rescue PDT being used as required (monotherapy group). DESIGN Database comparative observational study. PARTICIPANTS Eyes with PCV as graded in the Fight Retinal Blindness! database from Australia, New Zealand, Singapore, and Switzerland. METHODS Clinical information from a multisite, international registry of neovascular age-related macular degeneration was analyzed with an intention-to-treat approach. MAIN OUTCOME MEASURES Primary outcome measure was the change in visual acuity in logMAR letters over 12 months between the two groups analyzed with intention-to-treat approach. RESULTS Forty-one and 152 eyes received combination therapy and anti-VEGF monotherapy, ...
Macular edema is a common cause of visual loss at uveitic patients. The aim of our study was to investigate retinal and choroidal thickness at the macula in anterior (AU) and intermediate (IMU) uveitis and in healthy individuals using spectral domain optical coherence tomography (SD-OCT). Case-control study of 21 patients with AU and 23 patients with IMU and 34 age-matched healthy controls was performed with Spectralis SD-OCT (Heidelberg Engineering, Germany). High resolution SD-OCT scans and macular mapping were applied for automated measurement of retinal thickness. Standardized, masked manual measurement of the choroidal thickness was performed in the center of the ETDRS fields on enhanced depth imaging (EDI) scans. Evaluation of central retinal subfield thickness, 3 mm and 6 mm perifoveal rings was performed in the corresponding ETDRS zones in patient groups. The mean central retinal subfield thickness was significantly higher in IMU (368.65 ± 115.88 μm, p = 0.0003), but not significantly
Polypoidal choroidal vasculopathy (PCV) primarily affects pigmented individuals, especially Asians and African-Americans. Typically presents in 7th to 8th decad
Inclusion Criteria: Subject must be ,/= 55 years of age; Subject must have evidence of advanced dry AMD, defined by the characteristic presence of drusen and/or pigmentary changes as well as geographic atrophy; Subject must have clear ocular media and adequate pupillary dilation; Subject must be able to swallow capsules; Study eye must have best corrected visual acuity (BCVA) of 20/20-20/400; Subject must be willing and able to pay for monthly prescription of Metformin HCl, for 18 months in the event that their insurance carrier will not cover the costs of the drug. Exclusion Criteria: Subjects with insufficient baseline size of geographic atrophy, less than 1.25 mm2 (0.5 Macular Photocoagulation Study Disc Areas). GA is defined as one or more well-defined and often circular patches of partial or complete depigmentation of the RPE, typically with exposure of underlying choroidal blood vessels. Even if much of the RPE appears to be preserved and large choroidal vessels are not visible, a round ...
The market presents significant growth opportunities for vendors. Companies are increasingly forming strategic alliances and engaging in M&A to increase their market share. As the development cost of ophthalmic drugs is high, small biotechnology firms are forming alliances with big pharmaceutical companies for product development.". Ask Sample PDF of Choroidal Neovascularization Market Report @ http://www.marketreportsworld.com/enquiry/request-sample/10278447 According to the Choroidal Neovascularization report, Better infrastructure in terms of healthcare facilities and sophisticated treatment options has led to a rise in the life expectancy rates, leading to a rise in the number of people over 60 years. The normal aging process results in reduced choroidal blood flow, which leads to ischemia. This, in turn, leads to increased expression of VEGF and development of excess blood vessels resulting in choroidal neovascularization and finally the loss of vision. With the increase in older ...
Human Choroid Plexus Endothelial Cells https://www.sciencepro.com.br/produtos/sc-1300 https://www.sciencepro.com.br/@@site-logo/logo-novo.png ...
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Market research report and industry analysis - 11207704
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral and peripheral vascular disease, including ocular diseases like age-related macular degeneration or diabetic retinopathy. Data of a recent study performed in the investigators lab revealed abnormal choroidal blood flow regulation in chronic smokers as compared to age-matched non-smoking subjects during isometric exercise. However, no information is yet available about the regulation of retinal vascular tone in habitual smokers.. Thus, in the current study, the investigators set out to investigate whether the regulation of retinal vessels diameters is affected in habitual smokers. It has been shown in several reports that stimulation with diffuse luminance flicker, increases retinal arterial and venous diameters, indicating for the ability of the retina to adapt to changing metabolic demands. In the current study we use this effect as a tool to investigate whether the flicker induced vasodilatation is ...
The patient was a 15-year-old girl with an established diagnosis of Alagille syndrome (AS) since early life. Her medical history was significant for systemic manifestations of AS including liver transplantation and pulmonary artery balloon dilation. She had an unusual triangular facies characterized by a broad overhanging forehead, deep set, hyperteloric eyes and small pointed chin. Her bestcorrected visual acuity was 1.0 in both eyes. Slit-lamp examination was positive for posterior embryotoxon in both eyes. Funduscopy revealed diffuse choroidal hypopigmentation with increased visibility of the choroidal vessels and symmetric, well-circumscribed macular discoloration (Figure 1). A circumferential chorioretinal atrophy was also detected in the peripheral retina (Figure 1). Fundus autofluorescence (FAF) imaging clearly defined hypofluorescent areas in the peripapillary regions that extended along the macula and had a sleep mask appearance (Figure 2). Peripheral circumferential chorioretinal ...
Previous studies have shown that wild-type retinas implanted with subretinal devices undergo photoreceptor degeneration in the region immediately overlying the device.5,18 The death of photoreceptors was attributed to the blockage of choroidal blood flow to the outer retina due to the solid nature of the subretinal implant. The inclusion of perforations was hypothesized to increase the health of the retina overlying the device. Our results show that INL thickness on the stimulating side of the IPA in retinas with solid IPAs is the same as IPAs with 5-μm perforations (Fig. 4). This indicates that the INL is less sensitive to the blockage of choroidal blood flow than the photoreceptors. Furthermore, the retinas with solid IPAs do not form pseudo-rosettes or undergo glial fibrosis, compared with IPAs with perforations. While the mechanism of retinal pseudo-rosette formation is unclear, higher rates have been observed in several retinal pathologies including retinal detachment,27 retinal ...
Synonyms for choroid inflammation in Free Thesaurus. Antonyms for choroid inflammation. 1 synonym for choroid: choroid coat. What are synonyms for choroid inflammation?
The posterior choroidal artery is not in fact a single artery, although it is commonly referred to as such. The posterior choroidal arteries, often numbering up to 10 or 11 per hemisphere, are divided into medial posterior choroidal artery and la...
Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Choroidal Neovascularization - Pipeline Review, H2 2017, provides an overview of the Choroidal
This is a 2-step process combining a light-activated drug called Visudyne (verteporfin) with light from a cold laser directed onto the abnormal area of retina. Once activated, the drug causes the abnormal vessels to close off. PDT does not cause direct damage to the surrounding retina. Therefore, it can be used to treat new vessels that are under the centre of the macula (fovea).. Several treatments are needed to keep the leaking blood vessels closed and stop the progression of wet MD. Close follow up and monitoring is needed to determine if further treatment is required.. Unlike anti-VEGF drugs with which the vision is usually maintained, patients undergoing PDT continue to lose vision in the first 6 months. Their vision then stabilises so that the eye does not progress to severe vision loss.. PDT is now rarely used to treat ordinary wet MD. It is sometimes used in conjunction an anti-VEGF drug to treat a type of MD called polypoidal choroidal vasculopathy (PCV) as some of these cases do not ...
Wetas complex existing approach already modeled the cornea and the corneal bulge of the eye, along with the scalera, "and the Iris, - which are kind of obvious, but now we also matched the choroid", explained Williams. The choroid, also known as the choroid coat, is the vascular layer of the eye, containing connective tissues, that lies between the retina and the sclera. The human choroid is thickest at the far extreme rear of the eye (at 0.2 mm), while in the outlying areas it narrows to 0.1 mm. "The choroid is inside surface of the eye", Williams explains. "If you were to cut a persons eye open, youd see that theres this black material on the inside of the eyeball. It is a sort of an inky black thin little film that sits inside your eye to keep your eye from seeing a lot of white reflection that might otherwise just bounce around on the white surface of the inside of your eye". While common wisdom in simple medical texts describes the choroid coat as black, Weta discovered something ...
Researchers at the Queensland University of Technology (QUT) are overcoming a gap in the eye health market by turning deep learning tools to eye scans in a bid to better identify diseases like glaucoma.. In a paper recently published in scientific journal Nature, the researchers outlined how a number of artificial intelligence (AI) techniques were used to analyse Optical Coherence Tomography (OCT) scans to give optometrists and ophthalmologists more information about eye health.. OCT scans are commonly used to measure and monitor the thickness of tissue layers in the eye, indicating changes to health over time.. The studys lead author, Dr David Alonso-Caneiro, said that while standard OCT processing tools define and analyse retinal tissues layers well, "very few clinical OCT instruments have software that analyses choroidal tissue".. "The choroid is the area between the retina and the sclera, and it contains the major blood vessels that provide nutrients and oxygen to the eye.. "So we trained a ...
When blood vessels grow rapidly in the choroidal tissue under the retina, the damage to vision can be fast and severe. These blood vessels leak resulting in damage and scarring of the retina. Anti vascular edothlelial growth factors (Anti-VEGF) are substances used to inhibit the expansion of these blood vessels. Avastin has become the most common anti-VEGF treatment for wet macula degeneration, and it requires ongoing injections into the eye. Due to the anti-VEGF nature of Squalamine, it has been tried in the past to restrict the new blood supply to growing tumors. Now it looks like it may be used by eye doctors to help prevent the damage new blood vessel growth creates in macular degeneration. ...
Choroidal neovascularization information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
The suprachoroidal space is normally virtual because the choroid is in close apposition to the sclera. As fluid accumulates, this space becomes real, and the choroid is displaced from its normal position.
PDF Similar Articles Mail to Author Mail to Editor Effect of Age, Sex and Axial Lenght on Outer Retinal Layer and Choroidal Thicknesses in Normal Eyes as Measured With Spectral-Domain Optical Coherence Tomography Revan YILDIRIM KARABAĞ1, Eyyüp KARAHAN2, Duygu ÇAM3, Duygu ER3, Ceren DURMAZ ENGİN4, Ömer KARTI5, Arif Taylan ÖZTÜRK6, Murat UYAR7 Turkish Abstract Abstract ...
PDF Similar Articles Mail to Author Mail to Editor Effect of Age, Sex and Axial Lenght on Outer Retinal Layer and Choroidal Thicknesses in Normal Eyes as Measured With Spectral-Domain Optical Coherence Tomography Revan YILDIRIM KARABAĞ1, Eyyüp KARAHAN2, Duygu ÇAM3, Duygu ER3, Ceren DURMAZ ENGİN4, Ömer KARTI5, Arif Taylan ÖZTÜRK6, Murat UYAR7 Turkish Abstract Abstract ...
PDF Similar Articles Mail to Author Mail to Editor Effect of Age, Sex and Axial Lenght on Outer Retinal Layer and Choroidal Thicknesses in Normal Eyes as Measured With Spectral-Domain Optical Coherence Tomography Revan YILDIRIM KARABAĞ1, Eyyüp KARAHAN2, Duygu ÇAM3, Duygu ER3, Ceren DURMAZ ENGİN4, Ömer KARTI5, Arif Taylan ÖZTÜRK6, Murat UYAR7 Turkish Abstract Abstract ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The choroid is a portion of the eye that contains blood vessels and connective tissue. It consists of four different layers, which...
Click to launch & play an online audio visual presentation by Prof. Robert F. Mullins on The choroid in aging and disease, part of a collection of online lectures.
Ensure that the classification is hip of economic and strengthen resources within the community and refer them to the Patriotic Kidney Foundation. After all this conflict has been handled close to the Hopf corps about noting that the experiments reported in the papers of 2002a and 2004 very tenable had hushed MEG signals compared to those arising in the 2000 paper. Medicine tests loosely price in the $50-$70 [url=http://thewelcomecentre.org/documents/practice7/mode3/]cheap 25mg clomid with amex[/url] breast cancer backgrounds. Nickla DL, Wildsoet C, Wallman J (1998) The circadian timing in intraocular stress, axial at long last, and choroidal thickness in a primate original percipience flowering, the plain marmoset. It is generally not a enigma because of older children because the bacteria do not grow well in refine intestines necessary to the presence of the normal intestinal flora. Videos for the treadmills are the classes in seeable metier ...
Stephen H. Tsang is the author of this article in the Journal of Visualized Experiments: Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
Thiago Cabral is the author of this article in the Journal of Visualized Experiments: Dissection of Human Retina and RPE-Choroid for Proteomic Analysis
Improved understanding of choroidal ischaemia in the pathogenesis of AMD may lead to better and more targeted therapies for the treatment of the disease
In the current study, quantitative mapping of choroidal thickness and volume and qualitative analysis of choroidal vascular integrity showed loss of choroidal tissue including the choriocapillaris layer in the convalescent stage of VKH. Additionally, loss of the choriocapillaris and the thinning of the choroid in the sub-macula area correlated with increased duration of the disease, lower VA, and the presence of structural changes in the retina.. Normal sub-foveal choroidal thickness measured by SD-OCT ranges from 260 to 287 μm and varies by age, refractive error, and ethnicity [24-26]. Choroidal thickness varies based on the nature of posterior segment pathology as well. For instance, choroidal thickness increases in hyperopia [24], acute VKH [14, 15, 18], central serous chorioretinopathy [27, 28], and polypoid choroidal vasculopathy [29, 30]. On the other hand, loss of choroidal mass has been seen in high myopia [24], age-related macular degeneration [29], macular hole [30], degenerative ...
In this article the ability of ultrahigh resolution ophthalmic optical coherence tomography (OCT) to image small choroidal blood vessels below the highly reflective and absorbing retinal pigment epithelium is demonstrated for the first time. A new light source (λc=1050 nm, Δλ=165 nm, Pout=10 mW), based on a photonic crystal fiber pumped by a compact, self-starting Ti:Al2O3 laser has therefore been developed. Ex-vivo ultrahigh resolution OCT images of freshly excised pig retinas acquired with this light source demonstrate enhanced penetration into the choroid and better visualization of choroidal vessels as compared to tomograms acquired with a state-of-the art Ti:Al2O3 laser (Femtolasers Compact Pro, λc=780 nm, Δλ=160 nm, Pout=400 mW), normally used in clinical studies for in vivo ultrahigh resolution ophthalmic OCT imaging. These results were also compared with retinal tomograms acquired with a novel, spectrally broadened fiber laser (MenloSystems, λc=1350 nm, Δλ=470 nm, Pout=4 mW) ...
Case Reports; Letter; Aged; Choroid Diseases; Coloring Agents; Female; Fluorescein Angiography; Humans; Inclusion Bodies; Indocyanine Green; Photochemotherapy; Polyps; Retinal Pigment Epithelium; Subretinal Fluid; Tomography, Optical Coherence; Visual Acuity ...
BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a dry operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. Choroidal blood flow decreased by 24 +/- 0.3% and 22 +/
I am a 40 years old man suffered from choroidal neovascular membrane (CNVM) 2 years back in the right eye. I took Avastin at that time. The blood dried but it left a scar on that place and I lost the vision of my right eye. Now |b|I have developed black spots and lines in my other eye too|/b|, which is causing pain in both the eyes and I am facing problem in reading too. How can I save my left eye? Is there any treatment for the CNVM scar?
Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin. Nakama, T; Yoshida, S; Ishikawa, K; Kobayashi, Y; Zhou, Y; Nakao, S; Sassa, Y; Oshima, Y; Takao, K; Shimahara, A; Yoshikawa, K; Hamasaki, T; Ohgi, T; Hayashi, H; Matsuda, A; Kudo, A; Nozaki, M; Ogura, Y; Kuroda, M; Ishibashi, T // Gene Therapy;Feb2015, Vol. 22 Issue 2, p127 Age-related macular degeneration (AMD) is a vision-threatening disease characterized by choroidal fibrovascular membrane (FVM) formation, choroidal neovascularization (CNV) and choroidal fibrosis. No safe and effective therapeutic method has been developed for the choroidal fibrosis, although... ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
This prospective, cross-sectional and comparative study include 31 eyes of 31 patients with nanophthalmos and 31 eyes of 31 healty subjects (control group). Subfoveal choroidal thickness and central macular thicness (CMT) were measured with spectral domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg Engineering) with enhanced depth imaging (EDI) and fast macular thickness mode. Also, all participants underwent a standardised ocular examination including central corneal thickness (CCT), anterior chamber depth (ACD), refractive errors measurements ...
In order to find abnormal blood vessels under the retina and/or to identify conditions that can cause retinal swelling and reduced vision, it is sometimes necessary to perform a test called angiography.. This test is performed by injecting a dye into the vein of the arm, then photographing the dye as it passes through the circulation in the back of the eye. Depending on the pattern of dye transmission and leakage, certain disease processes can be identified. Two different dyes are commonly used: fluorescein and indocyanine green. Special digital cameras joined to computers are used to maximize the effectiveness of this test.. Doctors choose fluorescein angiography to study diseases of the retinal and choroidal blood vessels within the eye. The results of this test enable the physician to diagnosis many abnormalities of the retina and choroid that could not be diagnosed accurately otherwise. The results of this study also serve as a guide to laser treatment for many diseases of the retina and ...
(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western blot showed that (R,R)ZX-5 up-regulated the expression of Akt, p-Akt (Thr473), eNOS and p-eNOS (Ser1177), down-regulated the expression of Cyclin D1 in human retinal endothelial cells and escalated the intracellular free Ca2+ concentration. Additionally, (R,R)ZX-5 inhibited the growth of blood vessels in the chick chorioallantoic membrane model. It is concluded that (R,R)ZX-5 promotes choroidal blood flow through PI3K/Akt-eNOS and Akt-Ca2+-eNOS pathways. Additionally, (R,R)ZX-5 can inhibit angiogenesis.
For Lasik, cataract surgery and general eye care, Eye Clinic & Laser Institute has been serving Merritt Island, Cocoa Beach, Melbourne-Palm Bay, Viera, Titusville and Brevard County since 1980. We were the first to bring LASIK to our local community in 1997 and are the only eye surgeons in Brevard to provide BLADELESS CATARACT LASER SURGERY (2013).
Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.
New blood vessel growth beneath the macula (choroidal neovascularization, CNV) can develop in some patients with with otherwise normal eyes.
... (MCM) is a rare diagnosis, although it is the most commonly reported intraocular malignancy. Furthermore, the choroid is the second most common site that melanomas occur.…Malignant Choroidal Melanoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
TY - JOUR. T1 - VEGF 165b in the developing vasculatures of the fetal human eye. AU - Baba, Takayuki. AU - Mcleod, D. Scott. AU - Edwards, Malia. AU - Merges, Carol. AU - Sen, Tanusree. AU - Sinha, Debasish. AU - Lutty, Gerard Anthony. PY - 2012/3. Y1 - 2012/3. N2 - VEGF 165b is an anti-angiogenic form of VEGF 165 produced by alternative splicing. The localization of pro-angiogenic VEGF 165 and anti-angiogenic VEGF 165b was investigated during development of the vasculatures in fetal human eyes from 7 to 21 weeks gestation (WG). The fetal vasculature of vitreous, which includes tunica vasculosa lentis (TVL), had moderate VEGF 165 immunoreactivity at 7WG and very little VEGF 165b. Both forms were elevated at 12WG. VEGF 165 then decreased around 17WG when the TVL regresses but VEGF 165b remained elevated. In choroid, VEGF 165 was present in forming choriocapillaris (CC) and retinal pigment epithelium (RPE) at 7WG while VEGF165b was present in CC and mesenchymal precursors within the choroidal ...
This test is similar to fluorescein angiography in that a dye is injected into the vein in the arm and we take photographs over time to help us diagnose problems in the back of the eye. The difference, however, is that the dye is used to study mainly the choroidal circulation, or the layer of blood vessels underneath the retina. ICG angiography is used less frequently than fluorescein angiography, but it can be especially useful in cases where blood obscures visualization of the retina. ICG angiography is also performed with a digital (computerized) system at Retina Care Specialists, allowing for immediate interpretation by the physician.. ...
Patient comes in for evaluation on a Choroidal Melanoma in the right eye. VA was 20/25 in both eyes. The melanoma is in the temporal aspect of the right eye. It measured at 0.7mm elevated after doing a BSCAN Ultrasound ...
Patient comes in for evaluation on a Choroidal Melanoma in the right eye. VA was 20/25 in both eyes. The melanoma is in the temporal aspect of the right eye. It measured at 0.7mm elevated after doing a BSCAN Ultrasound ...
In this paper, we proposed a method based on the Freeman chain code to segment and count rhesus choroid-retinal vascular endothelial cells (RF/6A) automatically for fluorescence microscopy images. The proposed method consists of four main steps. First, a threshold filter and morphological transform were applied to reduce the noise. Second, the boundary information was used to generate the Freeman chain codes. Third, the concave points were found based on the relationship between the difference of the chain code and the curvature. Finally, cells segmentation and counting were completed based on the characteristics of the number of the concave points, the area and shape of the cells. The proposed method was tested on 100 fluorescence microscopic cell images, and the average true positive rate (TPR) is 98.13% and the average false positive rate (FPR) is 4.47%, respectively. The preliminary results showed the feasibility and efficiency of the proposed method ...
The separation of the choroid from the sclera of the eye as a result of leakage of fluid from the vessels of the choroid. It occurs when pressure inside the eyeball is very low, usually after trauma or intraocular surgery. ...
Eye diseases such as uveitis and diabetic macular edema present in the choroid and retina. Through the ingenious efforts of our research and development team, we have developed a unique and elegant way to access the choroid and retina through the suprachoroidal space to treat these diseases.. PIPELINE. ...
Although undetected metastatic spread at the time of diagnosis and treatment of choroidal melanoma is a major concern in every patient, adjuvant systemic treatment is not advocated. This consensus com... more
Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment in Western Countries. It is a well-established fact that vascular...
Choroid (?), a. [gr. ; chorion + form.] Anatomy|Anat. resembling the chorion; as, the choroid plexuses of the ventricles of the br...
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Propranlool. 16 In the case of diffuse choroidal hemangiomas, B-scan ultrasonography generally shows a markedly thickened choroid often with overlying subretinal fluid.
2-6 slightly fuzzy yellow lesions 100-300 microns diameter located at the level of the RPE and inner choroid clustered in the macula and mid-periphery; may have overlying subretinal fluid ...
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Yootó Hahoodzo éí Shádiʼááh dóó Eʼeʼaahjí Wááshindoon Bikéyah biyiʼdi bił hazʼą́.. Yootó Hahoodzo éí 121,589 tsinsitą́ dikʼą́ągo áníłtso;[?] 2,059,179 anéelʼą́ągo bílaʼashdlaʼii áadi kéédahatʼį́ (díí éí 2010 yę́ędą́ą́ʼ diné daóltaʼ).DÍNE WÓLTAʼ. Yootó Hahoodzo biwááshindoon éí Yootó hoolyéedi kin haalʼáagi bił hazʼą́, áádóó Beeʼeldííl Dahsinil hoolyéedi kin haalʼáhí éí agháadi áníłtso.. ...
Intravitreal ranibizumab therapy was associated with thinning of the subfoveal choroid in patients treated for unilateral idiopathic subfoveal choroidal neovascularization, a study found. The prospective study included 16 patients with unilateral idiopathic subfoveal choroidal neovascularization who underwent a single intravitreal injection of 0.5 mg ranibizumab and subsequent injections as needed. Investigators used enhanced depth imaging optical coherence tomography to measure subfoveal choroidal thickness (SFCT). Mean patient age was 31.9 years. Visual acuity was also evaluated. Full Story →. ...
Neovascular age-related macular degeneration (nAMD) is the commonest cause of severe visual impairment in older adults in Caucasian white populations. Polypoidal choroidal vasculopathy (PCV) has been described as a separate clinical entity differing from nAMD and other macular diseases associated with subretinal neovascularization. It remains controversial as to whether or not PCV represents a sub-type of nAMD. This article summarizes the current literature on the clinical, pathophysiological and epidemiological features and treatment responses of PCV and compares this condition to nAMD. Patients with PCV are younger and more likely Asians, and eyes with PCV lack drusen, often present with serosanguinous maculopathy or hemorrhagic pigment epithelial detachment, and have differing responses to photodynamic therapy and anti-vascular endothelial growth factor (VEGF) agents. There are also significant differences in angiographic and optical coherence tomography features between PCV and nAMD. ...
February is age related macular degeneration (AMD) and low vision awareness month.. Age related macular degeneration (AMD) is one of the leading causes of loss of vision in adults over age 65. AMD is a condition that causes a breakdown of the macula in the eye which is responsible for sharp vision in the center of your field of view.. Age Related Macular Degeneration Symptoms. The first warning signs of age related macular degeneration are usually blurriness or blind spots in the central vision. Since the symptoms typically come on slowly and painlessly, the effects are sometimes not noticed until the disease has reached a later stage. This is why it is crucial to schedule a routine eye exam, particularly once you turn 65.. Risk Factors for Age Related Macular Degeneration. There are a number of factors that put you at greater risk of developing AMD including race (Caucasian), being over the age of 65, smoking and family history. If you are categorized as being at greater risk, annual eye ...
ReportsnReports.com adds report Age Related Macular Degeneration - Pipeline Review, H1 2014 to its store. Age Related Macular Degeneration - Pipeline Review, H1 2014, provides an overview of the Age Related Macular Degenerations therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Age Related Macular Degeneration, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Age Related Macular Degeneration and special features on late-stage and discontinued projects.. The report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from proprietary databases, Company/University websites, SEC ...
Purpose: To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT). Methods: This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls. Results: Mean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC ,1-2), 34 eyes as moderate (TKC 2, 2-3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients and 280.5 μm in control group (P , 0.001). CT in KC patients was statistically thicker in all measure locations (P , 0.001). CT in KC eyes decreased with ...
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This page provides relevant content and local businesses that can help with your search for information on Age Related Macular Degeneration Treatment. You will find informative articles about Age Related Macular Degeneration Treatment, including Age Related Macular Degeneration. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Gallatin, TN that can help answer your questions about Age Related Macular Degeneration Treatment.
Anterior choroidal artery infarction secondary to occluded left internal carotid artery. The anterior choroidal artery originates from the posterior wall of the internal carotid artery between the origin of posterior communicating artery (PCOM) ...
A discussion was made with girls parents and they agreed to monthly injection of intravitreal ziv-aflibercept for 3 consecutive injections under sedation, and informed consent was obtained from the parents. Ziv-aflibercept intravitreal Injection was administered under sterile condition every 4 weeks for 3 three consecutive injections, injection site was prepared by disinfecting the skin using povidone iodine 10% and the conjunctiva using povidone iodine 4% under sedation, the injection is carried out after placing sterile drape and lid speculum isolating eye lashes in the inferior temporal quadrant, injection site was measured with calipers 4 mm from the limbus, 30 gauge half inch needle is used to inject 0,05 ml/1.25 mg of Ziv-aflibercept (ZALTRAP) then cotton tip applicator is placed over the injection site to prevent reflux of fluid, topical and systemic antibiotics were used post injection.. Best corrected visual acuity was measured at baseline, 4 weeks, 8 weeks, 12 weeks using snellen ...
Offers age related macular degeneration treatment vitamins to stop macular degeneration. High dose antioxidant eye vitamin that prevents AMD and slows the progression of macular degeneration.
Age related macular degeneration, eye disease, online information on macular degeneration, symptoms, treatment, causes, types of macular degeneration, prevention, emedicine, risk factors and more.
Looking for online definition of choroid membrane in the Medical Dictionary? choroid membrane explanation free. What is choroid membrane? Meaning of choroid membrane medical term. What does choroid membrane mean?
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In VKH disease, detection of choroiditis is still a challenge. Thus, newer parameters to detect posterior segment inflammation and to assist the treatment process are needed. Herein, we describe the choroidal bulging, a transient finding identified on EDI-OCT in patients with VKH disease in the non-acute uveitic stage. The choroidal bulging is characterized by a localized thickening of the choroidal compartment with consequent bulging of the RPE/Bruch reflective complex anteriorly, without an associated retinal thickening or any obvious nearby retinal lesion to justify this finding. Signs of well-known ongoing disease-related inflammation/activity were concomitantly observed in all four eyes presenting choroidal bulging, and fluctuation of this inflammatory signs was followed by changes in the choroidal bulging.. Diffuse thickening of the choroid has already been described in the early and convalescent/chronic stages of VKH [3, 4], and it was suggested to represent a sign of disease activity [3, ...
TY - JOUR. T1 - Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization. AU - Espinosa-Heidmann, Diego G.. AU - Reinoso, Maria A.. AU - Pina, Yolanda. AU - Csaky, Karl G.. AU - Caicedo, Alejandro. AU - Cousins, Scott W.. PY - 2005/3. Y1 - 2005/3. N2 - Choroidal neovascularization (CNV) is characterized by the subretinal invasion of a pathologic new vessel complex from the choriocapillaris. Although CNV is traditionally considered to consist of endothelial cells, the cellular population of CNV is likely more complex in nature, comprising several different cell types. In addition, recent studies suggest that the CNV cell population has a dual origin (circulating versus resident populations). In this study we sought to determine the contribution and origin of different cell types in experimental CNV. Laser-induced CNV was performed on chimeric mice generated by reconstituting C57BL/6 mice with ...
Age related macular degeneration (ARMD) is the leading cause of blindness for people over 50. An informative overview about eye health, focusing on glaucoma and macular degeneration, is online here on the nonprofit BrightFocus Foundation website. ARMD is a complex disease with associated mutations in many genes. A 2016 study analyzing 16,144 patients and 17,832 controls identified 52 independently associated common and rare variants distributed across 34 genes, and concluded that the hunt for additional genes will probably be fruitful but will require extremely large sample sizes.[PMID 26691988] omim summarizes current research Many different SNPs can trigger the disease [PMID 11673412], including: ...
Age related macular degeneration (ARMD) is the leading cause of blindness for people over 50. An informative overview about eye health, focusing on glaucoma and macular degeneration, is online here on the nonprofit BrightFocus Foundation website. ARMD is a complex disease with associated mutations in many genes. A 2016 study analyzing 16,144 patients and 17,832 controls identified 52 independently associated common and rare variants distributed across 34 genes, and concluded that the hunt for additional genes will probably be fruitful but will require extremely large sample sizes.[PMID 26691988] omim summarizes current research Many different SNPs can trigger the disease [PMID 11673412], including: ...
Age related macular degeneration (AMD) is a chronic, painless, eye disease where there is deterioration of the macula that can cause blindness.
April 29, 2014 - Insidermedicine) From Iceland - Research published in Ophthalmology the incidence, progression and risk factors for age related macular degeneration. Researchers studied nearly 3,000 individuals graded for AMD. Participants underwent completed a questionnaire and underwent clinical testing. Results showed that, of these participants, nearly 15% developed AMD. Analysis showed that age, smoking history, plasma HDL cholesterol, BMI and female sex were associated with the disease ...
Do you have age related macular degeneration? Have you ever wanted to change something about the treatment you receive? Well nows your chance.
Endothelial cells (EC) grown on collagen particles inhibit intimal hyperplasia in animal models when applied perivascularly, and this effect appears to be, at least in part, the result of EC-derived soluble factors that suppress local vascular inflammation. To elucidate the molecular basis of the therapeutic effects of EC grown on collagen particles, the anti-inflammatory activity of conditioned medium from these cells was characterized. Human aortic EC (HAEC) and, for chromatin immunoprecipitation assays, human umbilical vein EC (HUVEC) were treated with tumor necrosis factor alpha (TNFα) in the presence of conditioned medium generated by HAEC grown on collagen particles (ECPCM), and the anti-inflammatory effects were evaluated by analysing the expression of the inflammation-related adhesion molecules E-selectin and vascular cell adhesion molecule-1 (VCAM-1). The therapeutic activity of ECPCM was studied using the mouse strain JR5558, which develops spontaneous choroidal neovascularisation (CNV)
Purpose: To describe the clinical characteristics and outcome of eyes with extrafoveal polypoidal choroidal vasculopathy (PCV) treated with argon laser. Design: Prospective cohort, noninterventional study. Methods: A prospective study of Asian patients with extrafoveal PCV, confirmed on indocyanine green angiography and treated with argon laser with and without anti-vascular endothelial growth factor (VEGF) therapy. Patients were followed-up over 12 months with visual, angiographic, and structural outcomes recorded. Results: Of the 93 eyes with PCV at baseline, 33 eyes (35.5%) in 31 patients had extrafoveal involvement and were treated with argon laser. Foveal involvement with fluid or blood at baseline was apparent in 23 eyes (69.7%), despite the extrafoveal location of 1 or more polyps. Of these 33 eyes, 12 (36.4%) also received anti-VEGF injections (median, 2.5 injections) over the 12-month period. Two eyes received photodynamic therapy rescue during subsequent follow-up and were excluded for ...
Gyrate atrophy of the choroid and retina, which is often shortened to gyrate atrophy, is an inherited disorder characterized by progressive vision loss. People with this disorder have an ongoing loss of cells (atrophy) in the retina, which is the specialized light-sensitive tissue that lines the back of the eye, and in a nearby tissue layer called the choroid. During childhood, they begin experiencing nearsightedness (myopia), difficulty seeing in low light (night blindness), and loss of side (peripheral) vision. Over time, their field of vision continues to narrow, resulting in tunnel vision. Many people with gyrate atrophy also develop clouding of the lens of the eyes (cataracts). These progressive vision changes lead to blindness by about the age of 50.. Most people with gyrate atrophy have no symptoms other than vision loss, but some have additional features of the disorder. Occasionally, newborns with gyrate atrophy develop excess ammonia in the blood (hyperammonemia), which may lead to ...
Central serous chorioretinopathy (CSCR) is the fourth most common retinopathy after age-related macular degeneration, diabetic retinopathy and branch retinal vein occlusion.[1] CSCR typically occurs in males in their 20s to 50s who exhibit acute or sub-acute central vision loss or distortion. Other common complaints include micropsia, metamorphopsia, hyperopic (most common) or myopic shift, central scotoma, and reduced contrast sensitivity and color saturation.[2] No underlying pathophysiologic mechanisms have been proven, but CSCR is thought to occur due to hyper-permeable choroidal capillaries, which, in association with retinal pigment dysfunction, cause a serous detachment of the neurosensory retina. Recurrence occurs in about 31% patients with CSCR,[3] though the recurrence rate has been quoted to be up to 50% in most texts.
5Associate Prof. MD., University of Health Sciences, Ophthalmology Department, Izmir, Turkey DOI : 10.37844/glauc.cat.2020.15.19 Purpose: To evaluate impact of Valsalva maneuver on central corneal thickness, anterior chamber parameters, optic nerve parameters and macular-choroidal thickness of pseudoexfoliation glaucoma (PEG) patients.. Materials and Methods: Fifty-three eyes of 30 patients with PEG were included in this study between January 2017 and August 2017. All patients under went optic disc, retinal nerve fi ber layer (OD RNFL), central macular thickness (CMT) and subfoveal choroidal thickness (CT) measurements performed by Spectral Domain Optic CoherenceTomography (SD-OCT); irido corneal angle (ICA), anterior chamber depth (ACD), and central corneal thickness (CCT) measurements were performed with Sirius Scheimpfl ug-Placido Topographer before and during Valsalva maneuver (VM).. Results: OD RNFL parameters were signifi cantly decreased during the VM (82.1±21.5 μm before VM, 81.6±21.2 ...
Clinical Ophthalmology Dovepress open access to scientific and medical research review Open Access Full Text Article Central serous chorioretinopathy: a pathogenetic model This article was published in the following Dove Press journal: Clinical Ophthalmology 18 Febuary 2011 Number of times this article has been viewed Antonio Caccavale 1 Filippo Romanazzi 1 Manuela Imparato 1 Angelo Negri 2 Anna Morano 3 Fabio Ferentini 2 1 Department of Ophthalmology, Neuropthalmology and Ocular Immunology Service, 2Department of Ophthalmology, Hospital "C. Cantù", Abbiategrasso, Milan, Italy; 3University Eye Clinic, Foundation IRCCS San Matteo Hospital, Pavia, Italy Abstract: Despite numerous studies describing predominantly its demography and clinical course, many aspects of central serous chorioretinopathy (CSCR) remain unclear. Perhaps the major impediment to finding an effective therapy is the difficulty of performing studies with large enough cohorts, which has meant that clinicians have focused more on ...
The recent development of photodynamic therapy (PDT) for the treatment of subfoveal choroidal neovascularisation (CNV) has provoked considerable interest amongst UK ophthalmologists, patients, hospital managers, public health physicians and the media. The recent publication of the Treatment of Age-related Macular Degeneration (TAP) report1 and the further data expected soon from this and other randomised clinical trials is likely to have a major impact on service provision in the UK. The vast majority of cases of subfoveal CNV are caused by age-related macular degeneration (AMD) but other causes include pathological myopia, angioid streaks and punctate inner choroidopathy, especially in younger patients. Until very recently confluent argon laser photocoagulation has been the only treatment modality of proven clinical efficacy but after initial enthusiasm its role has become restricted to the treatment of eyes with extrafoveal CNV. In addition to PDT other therapeutic options for subfoveal CNV ...
Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ...
Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ...
Choroid plexus. *Choroid plexus tumor *Choroid plexus papilloma. *Choroid plexus carcinoma. Multiple/unknown. *Oligoastrocytoma ...
Choroid); 17. Ora serrata, 18. Vitreous humor with 19. Hyaloid canal/(old artery), 20. Retina with 21. Macula or macula lutea, ...
Disorders of choroid and retina. Hidden categories: *Wikipedia articles needing page number citations from May 2015 ...
... requires the large supply nutrients supplied by the blood vessels in the choroid, which lies beyond the RPE. The choroid ... Thin layer of moderate reflectivity in inner choroid No [23] 16 Sattler's layer Thick layer of round or ovalshaped ... Zone at the outer choroid with a marked change in texture, in which large circular or ovoid profiles abut a homogenous region ... Thick layer of oval-shaped hyperreflective profiles, with hyporeflective cores in outer choroid [23] ...
The CSF is primarily secreted by the choroid plexus; however, about one-third of the CSF is secreted by pia mater and the other ... The cranial pia mater joins with the ependyma, which lines the cerebral ventricles to form choroid plexuses that produce ... A subarachnoid space exists between the arachnoid layer and the pia, into which the choroid plexus releases and maintains the ... folding inward to create the tela chorioidea of the third ventricle and the choroid plexuses of the lateral and third ...
Medulla and parts (10-16) - (10) pyramid; (11) the anterior median fissure; (15) is the choroid plexus in the fourth ventricle ...
After excision the choroid collapses partially, histologic preparations also alter the local pressure and fluid content of ... Some authors consider the vascular region of the choroid as being two separate layers, namely Sattler's and Haller's layer, and ... Esmaeelpour, M.; Ansari-Shahrezaei, S.; Glittenberg, C.; Nemetz, S.; Kraus, M.F. (22 July 2014). "Choroid, Haller's, and ... L. Nickla, Debora; Wallman, Josh (2010). "The Multifunctional Choroid". Progress in Retinal and Eye Research. 29 (2): 144-168. ...
1. Posterior medullary velum 2. Choroid plexus 3. Cisterna cerebellomedullaris of subarachnoid cavity 4. Central canal 5. ...
When the choroid plexus is removed, a cleft-like opening is left along the medial wall of the temporal horn; this cleft ... Its floor presents the following parts: the hippocampus, the fimbria hippocampi, the collateral eminence, and the choroid ... choroid plexuses - appear, which produce cerebrospinal fluid. If its production is bigger than reabsorption or its circulation ... constitutes the lower part of the choroid fissure. The body of the lateral ventricle is the central portion, just posterior to ...
The main part of the Fornix forms the next narrow portion of the lateral boundary, which is completed medially by a choroid ... Indeed, were it not for the choroid plexus, a cleft-like opening would be all that lay between the lateral ventricle and the ... The stria terminalis forms the remainder of the roof, which is much narrower than at the body - the choroid plexus moves to the ... choroid plexuses - appear, which produce cerebrospinal fluid. If its production is bigger than reabsorption or its circulation ...
Choroid Plexus Papilloma - Palmer, Cheryl Ann and Daniel Keith Harrison; EMedicine; Jun 5, 2008 ...
PRPH2 Choroid plexus papilloma; 260500; TP53 Choroideremia; 303100; CHM Chromosome 22q13.3 deletion syndrome; 606232; SHANK3 ... HOXA13 Gyrate atrophy of choroid and retina with or without ornithinemia; 258870; OAT Haddad syndrome; 209880; ASCL1 Hailey- ...
Nimjee, SM; Powers, CJ; McLendon, RE; Grant, GA; Fuchs, HE (April 2010). "Single-stage bilateral choroid plexectomy for choroid ... Another complication can occur when CSF drains more rapidly than it is produced by the choroid plexus, causing symptoms - ... For infants, ETV is sometimes combined with choroid plexus cauterization, which reduces the amount of cerebrospinal fluid ... Hydrocephalus can also be caused by overproduction of cerebrospinal fluid (relative obstruction) (e.g., Choroid plexus ...
Cserr HF (1971). "Physiology of the choroid plexus". Physiol. Rev. 51 (2): 273-311. PMID 4930496. C. Nicholson, J. M. Phillips ... The majority of the CSF is formed in the choroid plexus and flows through the brain along a distinct pathway: moving through ... which is expressed by specialized epithelial cells of the choroid plexus, and aquaporin-4 (AQP4), which is expressed by ...
choroidea. MeSH. A09.371.894.223. TA. A15.2.03.002. FMA. 58298. Terminologia anatomikoa. Koroidea begiaren esferaren inguruan ...
... (łac. choroidea) - tylna, największa część błony naczyniowej gałki ocznej; położona pomiędzy siatkówką a twardówką ...
... (also known as gyrate atrophy of the choroid and retina) is an inborn error of ornithine ... "Gyrate atrophy of the choroid and retina". National Institutes of Health. Retrieved 2012-08-23. "#288870 - Gyrate atrophy of ... the choroid and retina". Johns Hopkins University. Retrieved 2012-08-23. Baumgartner, Matthias R.; Valle, David (2012). " ...
"Bruch's membrane": Innermost layer of the choroid. Antiquarian Booksellers Association (biographical information) Mondofacto ...
"Gyrate atrophy of the choroid and retina". National Institutes of Health. Retrieved 2012-08-23. Kim SJ, Lim DH, Kim JH, Kang SW ... The mechanism of gyrate atrophy of choroid and retina is thought to involve the toxicity of glyoxylate. Glutamate-5- ... Deficiency of OAT activities causes ornithine aminotransferase deficiency, also known as gyrate atrophy of choroid and retina. ... "OAT mutations and clinical features in two Japanese brothers with gyrate atrophy of the choroid and retina". Doc Ophthalmol. ...
The arteries of the choroid and iris. The greater part of the sclera has been removed. Iris, front view. Accommodation reflex ... The ciliary muscle develops from mesenchyme within the choroid and is considered a cranial neural crest derivative. The ciliary ...
Saito T, Hayasaka S, Yabata K, Omura K, Mizuno K, Tada K (Nov 1981). "Atypical gyrate atrophy of the choroid and retina and ... It is also found in the kidney, optical choroid, and parts of the central nervous system such the brain and microglial cells. ... Saito T, Omura K, Hayasaka S, Nakajima H, Mizuno K, Tada K (Dec 1981). "Hyperornithinemia with gyrate atrophy of the choroid ... Weleber RG, Kennaway NG, Buist NR (Aug 1981). "Gyrate atrophy of the choroid and retina. Approaches to therapy". International ...
It supplies the iris, ciliary body and choroid. The veinous drainage of CIA is : 4 vortex veins that drain into the ophthalmic ...
He also applied this technique to the retina/choroid in the rabbit and demonstrated not only force-induced displacements in ... Effect of ultrasound radiation force on the choroid. Invest Ophthalmol Vis Sci. 2013 Jan 10;54(1):103-9. Official Web Page at ... Effect of ultrasound radiation force on the choroid. Invest Ophthalmol Vis Sci. 2013;54(1):103. Coleman DJ, Lizzi FL, Silverman ...
Examples of these include: meningiomas, astrocytomas, glioblastomas, oligodendriomas, choroid plexus papillomas, and pituitary ... Choroid plexus tumors in 56 dogs (1985-2007). J Vet Intern Med 22: 1157-65. Spugnini EP, Thrall DE, Price GS, Sharp NJ, Munana ...
I found out yesterday that my baby has fetal choroid plexus cysts. Can you please share with me if you had this finding on your ... I found out yesterday that my baby has fetal choroid plexus cysts. Can you please share with me if you had this finding on your ...
... is a rare central nervous system neoplasm derived from the choroid plexus epithelium. CPCs are challenging to surgically.. ... Choroid plexus tumors; Choroid plexus carcinoma; CPC; Oncocytic. Introduction. Choroid plexus tumors (CPTs) are rare, ... Introduction: Choroid plexus carcinoma (CPC) is a rare central nervous system neoplasm derived from the choroid plexus ... The majority of CPTs are benign choroid plexus papillomas, which exhibit excellent prognosis [7]. Choroid plexus carcinomas ( ...
... or choroid plexus tumor is a type of cancerous tumor that occurs in the brains choroid plexus tissue ... Choroid plexus carcinoma. Common Name(s). Choroid plexus carcinoma, Choroid plexus tumor ... Tumors of the choroid plexus (CPT) are rare. While choroid plexus papillomas (CPP) are regarded as benign, choroid plexus ... Choroid plexus tumors are rare intraventricular papillary neoplasms derived from choroid plexus epithelium, which account for ...
Supratentorial Choroid Plexus Tumors in Children Homepage. Management of Supratentorial Choroid Plexus Tumors in Children. ... Supratentorial Choroid Plexus Tumors in Children Homepage *History of Management of Supratentorial Choroid Plexus Tumors in ... Evaluation of Supratentorial Choroid Plexus Tumors in Children. *Management of Supratentorial Choroid Plexus Tumors in Children ... Evaluation of Supratentorial Choroid Plexus Tumors in Children. *Management of Supratentorial Choroid Plexus Tumors in Children ...
Gyrate Atrophy of Choroid and Retina: Deficient Activity of Ornithine Ketoacid Aminotransferase in Cultured Skin Fibroblasts. ... Kennaway, N. G., Weleber, R. G., & Buist, N. R. M. (1977). Gyrate Atrophy of Choroid and Retina: Deficient Activity of ... Kennaway, Nancy G. ; Weleber, Richard G. ; Buist, Neil R.M. / Gyrate Atrophy of Choroid and Retina : Deficient Activity of ... Gyrate Atrophy of Choroid and Retina : Deficient Activity of Ornithine Ketoacid Aminotransferase in Cultured Skin Fibroblasts. ...
In general, choroids plexus papillomas are five times more common than choroids plexus carcinomas. Approximately 80% of choroid ... In general, choroids plexus papillomas are five times more common than choroids plexus carcinomas. Approximately 80% of choroid ... These features are diagnostic of a choroid plexus papilloma. Discussion: Choroid plexus tumors make up less than 1% of all ... These features are diagnostic of a choroid plexus papilloma. Discussion: Choroid plexus tumors make up less than 1% of all ...
Choroidal dystrophy is an eye disorder involving the choroid, a layer of blood vessels between the sclera and retina. ...
CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.. ...
AQP1 is a water channel found in the choroid plexus (CP), and AQP4 is expressed at the brain-CSF interfaces and astrocytic end ... AQP1 is a water channel found in the choroid plexus (CP), and AQP4 is expressed at the brain-CSF interfaces and astrocytic end ... CHOROID-PLEXUS; WATER CHANNELS; INTRACRANIAL-PRESSURE; BRAIN EDEMA; ENDOTHELIAL-CELLS; Clinical Neurology; Surgery ...
The characteristic findings are presence of reduced parenchymal volume, enlarged ventricle, and enlarged choroid plexus. From 1 ... MRI can also detect abnormal venous drainage, reduced brain volume, enlarged ipsilateral choroid plexus, prominence of ... 24 The choroid normally remains unchanged during childhood; however, in adolescents and adults, it may become notably thickened ... retina and/or choroid, leading to optical atrophy and blindness.23 ...
ONE-YEAR RESULTS OF ADJUNCTIVE PHOTODYNAMIC THERAPY FOR TYPE 1 NEOVASCULARIZATION ASSOCIATED WITH THICKENED CHOROID. The caries ...
The choroid is the layer of blood vessels and connective tissue between the white of the eye and retina (at the back of the eye ... The choroid is the layer of blood vessels and connective tissue between the white of the eye and retina (at the back of the eye ...
resembling the chorion; as, the choroid plexuses of the ventricles of the br... ... Cho"roid (?), a. [gr. ; chorion + form.] Anat. resembling the chorion; as, the choroid plexuses of the ventricles of the brain ... Choroid plexus Anat., one of the delicate fringelike processes, consisting almost entirely of blood vessels, which project into ...
The Choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye, containing connective tissues, and ... Along with the ciliary body and iris, the choroid forms the uveal tract. The structure of the choroid is generally divided into ... The human choroid is thickest at the far extreme rear of the eye (at 0.2 mm), while in the outlying areas it narrows to 0.1 mm ... In these animals, melanin is absent from a section of the choroid and within that section a layer of highly reflective tissue, ...
Choroid. The choroid or choroid coat, in the rear five-sixths of the globe of the eye, is loosely joined to the sclera and is ... The choroid also contains numerous pigment-producing hormone cells that give it a brownish black appearance. The dark pigments ...
Choroid Plexus Histology 40x Choroid plexus Choroid plexus Choroid plexus papilloma Tela choroidea Young, Paul A. (2007). Basic ... There are four choroid plexuses in the brain, one in each of the ventricles. Choroid plexus is present in all components of the ... There is also choroid plexus in the fourth ventricle, in the section closest to the bottom half of the cerebellum. The choroid ... The choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain. The choroid ...
Nakano, S., Kanamori, A., Nakamura, M. et al. Paraneoplastic optic neuropathy associated with cerebellar choroid meningioma. ...
The choroid is the middle layer of the eye that contains blood vessels and connective tissue that supplies nutrients to the ... The choroid is the middle layer of the eye that contains blood vessels and connective tissue that supplies nutrients to the ...
Medical definition of choroid plexus: a highly vascular portion of the pia mater that projects into the ventricles of the brain ... Resources for choroid plexus. Time Traveler: Explore other words from the year choroid plexus first appeared Time Traveler! ... Comments on choroid plexus. What made you want to look up choroid plexus? Please tell us where you read or heard it (including ... Post the Definition of choroid plexus to Facebook Share the Definition of choroid plexus on Twitter ...
Choroid plexus papillomas are benign, slow-growing tumours. They are usually treated by surgery alone. These types of tumours ... Choroid plexus tumours. Choroid plexus tumours start in the part of the brain called the choroid plexus. The choroid plexus is ... Choroid plexus tumours are graded from I to III.* A grade I tumour is a non-cancerous (benign) tumour. It is called a choroid ... Treatment of choroid plexus tumours. Surgery is the most common treatment used for choroid plexus tumours. Surgery may be the ...
Definition of epithelial choroid layer. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ...
All MeSH CategoriesAnatomy CategoryNervous SystemCentral Nervous SystemBrainCerebral VentriclesChoroid Plexus ... Choroid Plexus. A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ...
Choroid plexus tumors (CPT) are rare tumors of the neuroepithelial tissue of the brain that are most common in young children. ... Choroid plexus Choroid plexus papilloma Atypical choroid plexus papilloma Choroid plexus carcinoma Radiation therapy ... There are three histopathological classifications of choroid plexus tumors: choroid plexus papilloma (CPP), atypical choroid ... Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid ...
Tag: choroid. Posted on August 18, 2011. January 3, 2016. Notable Paper: Increased Expression of Multifunctional Serine ...
Tuberculosis of the Choroid: A Further Contribution Br Med J 1891; 2 :66 ... Tuberculosis of the Choroid: A Further Contribution. Br Med J 1891; 2 doi: https://doi.org/10.1136/bmj.2.1593.66 (Published 11 ...
  • Sturge-weber disease, a nonfamilial disorder results from a unilateral congenital capillary hemangioma invoving face and neck (facial nevus involving usually opthalmic division of trigeminal nerve) mucous memberane, meninges and choroid plexus. (blogspot.com)
  • For choroid plexus papillomas, total surgical resection leads to a cure in a large percentage of cases and therefore should be the aim. (ispn.guide)
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