AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Chorionic VilliChorionic Villi SamplingPrenatal DiagnosisAmniocentesisPregnancy Trimester, FirstPregnancyTrophoblastsPlacentaFetal DiseasesChromosome DisordersFetomaternal TransfusionKaryotypingPregnancy, TubalGestational AgeUltrasonography, PrenatalAbortion, SpontaneousMethemalbuminChorionTrisomyAmniotic FluidPlacentationDown SyndromeCordocentesisPregnancy, High-RiskMaternal AgeMosaicismAmnionAneuploidyHydatidiform MoleNeckAbortion, EugenicChromosome AberrationsDeciduaAbortion, SepticCrown-Rump LengthPregnancy Reduction, MultifetalPregnancy Trimester, SecondFetusNuchal Translucency MeasurementPregnancy, MultipleIntestine, SmallPre-EclampsiaPregnancy Trimester, ThirdJejunumGenetic CounselingIntestinal Mucosabeta-ThalassemiaAbortion, InducedPregnancy OutcomeChoriocarcinomaLeukemia Inhibitory Factor Receptor alpha SubunitMicrovilliHeterozygote DetectionChromosomes, Human, Pair 18IleumFetal DeathAbnormalities, MultipleBasement MembraneImmunohistochemistryFluorescent Antibody Technique
Chorionic Villi: The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).Chorionic Villi Sampling: A method for diagnosis of fetal diseases by sampling the cells of the placental chorionic villi for DNA analysis, presence of bacteria, concentration of metabolites, etc. The advantage over amniocentesis is that the procedure can be carried out in the first trimester.Prenatal Diagnosis: Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.Amniocentesis: Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.Pregnancy Trimester, First: The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Fetal Diseases: Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.Chromosome Disorders: Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)Fetomaternal Transfusion: Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)Karyotyping: Mapping of the KARYOTYPE of a cell.Pregnancy, Tubal: The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Ultrasonography, Prenatal: The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.Methemalbumin: A 1:1 molar complex of heme or hematin and albumin formed after the dissociation of methemoglobin into heme or hematin and globin in plasma. This complex, which imparts a coffee-brown color to plasma, occurs in hemolytic and hemorrhagic disorders. Its presence in plasma is used as a test to differentiate between hemorrhagic and edematous pancreatitis.Chorion: The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.Trisomy: The possession of a third chromosome of any one type in an otherwise diploid cell.Amniotic Fluid: A clear, yellowish liquid that envelopes the FETUS inside the sac of AMNION. In the first trimester, it is likely a transudate of maternal or fetal plasma. In the second trimester, amniotic fluid derives primarily from fetal lung and kidney. Cells or substances in this fluid can be removed for prenatal diagnostic tests (AMNIOCENTESIS).Placentation: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)Cordocentesis: The collecting of fetal blood samples typically via ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION from the umbilical vein.Pregnancy, High-Risk: Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.Maternal Age: The age of the mother in PREGNANCY.Mosaicism: The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.Amnion: The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.Aneuploidy: The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).Hydatidiform Mole: Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.Neck: The part of a human or animal body connecting the HEAD to the rest of the body.Abortion, Eugenic: Abortion performed because of possible fetal defects.Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Decidua: The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.Abortion, Septic: Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.Crown-Rump Length: In utero measurement corresponding to the sitting height (crown to rump) of the fetus. Length is considered a more accurate criterion of the age of the fetus than is the weight. The average crown-rump length of the fetus at term is 36 cm. (From Williams Obstetrics, 18th ed, p91)Pregnancy Reduction, Multifetal: Selective abortion of one or more embryos or fetuses in a multiple gestation pregnancy. The usual goal is to improve the outcome for the remaining embryos or fetuses.Pregnancy Trimester, Second: The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Nuchal Translucency Measurement: A prenatal ultrasonography measurement of the soft tissue behind the fetal neck. Either the translucent area below the skin in the back of the fetal neck (nuchal translucency) or the distance between occipital bone to the outer skin line (nuchal fold) is measured.Pregnancy, Multiple: The condition of carrying two or more FETUSES simultaneously.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.Pregnancy Trimester, Third: The last third of a human PREGNANCY, from the beginning of the 29th through the 42nd completed week (197 to 294 days) of gestation.Jejunum: The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.Genetic Counseling: An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.beta-Thalassemia: A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.Abortion, Induced: Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).Leukemia Inhibitory Factor Receptor alpha Subunit: A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.Microvilli: Minute projections of cell membranes which greatly increase the surface area of the cell.Heterozygote Detection: Identification of genetic carriers for a given trait.Chromosomes, Human, Pair 18: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Abnormalities, MultipleBasement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. (1/382)

Employing uteroplacental tissue at Day 35 of gestation, we determined the nucleic acid sequence of canine preprorelaxin using reverse transcription- and rapid amplification of cDNA ends-polymerase chain reaction. Canine preprorelaxin cDNA consisted of 534 base pairs encoding a protein of 177 amino acids with a signal peptide of 25 amino acids (aa), a B domain of 35 aa, a C domain of 93 aa, and an A domain of 24 aa. The putative receptor binding region in the N'-terminal part of the canine relaxin B domain GRDYVR contained two substitutions from the classical motif (E-->D and L-->Y). Canine preprorelaxin shared highest homology with porcine and equine preprorelaxin. Northern analysis revealed a 1-kilobase transcript present in total RNA of canine uteroplacental tissue but not of kidney tissue. Uteroplacental tissue from two bitches each at Days 30 and 35 of gestation were studied by in situ hybridization to localize relaxin mRNA. Immunohistochemistry for relaxin, cytokeratin, vimentin, and von Willebrand factor was performed on uteroplacental tissue at Day 30 of gestation. The basal cell layer at the core of the chorionic villi was devoid of relaxin mRNA and immunoreactive relaxin or vimentin but was immunopositive for cytokeratin and identified as cytotrophoblast cells. The cell layer surrounding the chorionic villi displayed specific hybridization signals for relaxin mRNA and immunoreactivity for relaxin and cytokeratin but not for vimentin, and was identified as syncytiotrophoblast. Those areas of the chorioallantoic tissue with most intense relaxin immunoreactivity were highly vascularized as demonstrated by immunoreactive von Willebrand factor expressed on vascular endothelium. The uterine glands and nonplacental uterine areas of the canine zonary girdle placenta were devoid of relaxin mRNA and relaxin. We conclude that the syncytiotrophoblast is the source of relaxin in the canine placenta.  (+info)

Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (2/382)

Trophinin, tastin, and bystin comprise a complex mediating a unique homophilic cell adhesion between trophoblast and endometrial epithelial cells at their respective apical cell surfaces. In this study, we prepared mouse monoclonal antibodies specific to each of these molecules. The expression of these molecules in the human placenta was examined immunohistochemically using the antibodies. In placenta from the 6th week of pregnancy, trophinin and bystin were found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface. Tastin was exclusively present on the apical side of the syncytiotrophoblast. Tissue sections were also examined by in situ hybridization using RNA probes specific to each of these molecules. This analysis showed that trophoblast and endometrial epithelial cells at the utero placental interface express trophinin, tastin, and bystin. In wk 10 placenta, trophinin and bystin were found in the intravillous cytotrophoblast, while tastin was not found in the villi. After wk 10, levels of all three proteins decreased and then disappeared from placental villi.  (+info)

CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5. (3/382)

The CD9 molecule is a 24-27 kDa cell surface glycoprotein, which may be related to Schwann cell migration and adhesion. In this study, we examined the expression of CD9 in human extravillous trophoblasts, which invade into the endometrium during implantation and placentation. CD9 was detected immunohistochemically on the extravillous trophoblasts in the cell columns of first trimester placentae, but not on villous trophoblasts. In the second and third trimester, CD9 was highly expressed on the extravillous trophoblasts in the basal plate of placentae, and in the chorion laeve in the fetal membrane of term placentae. The molecular mass of CD9 in the chorion laeve was shown to be 27 kDa by Western blotting. The mRNA of CD9 was also detected in the chorion laeve by reverse transcription-polymerase chain reaction (RT-PCR). Proteins were purified from chorion laeve by affinity chromatography with anti-integrin alpha3 and alpha5 monoclonal antibodies and Western blotting, revealed that CD9 was associated with both integrins. These findings indicate that CD9 is a differentiation-related molecule present in the extravillous trophoblasts. Since it is associated with integrin alpha5 which has been proposed to regulate trophoblast invasion, CD9 may be implicated in trophoblast invasion at the feto-maternal interface.  (+info)

Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta. (4/382)

The primary objective of this study was to characterize an in-vitro model of the human placenta using morphological, biochemical and physiological parameters. Placental villi were obtained from normal first trimester and term pregnancies. The villi were incubated with Dulbecco's modified Eagle's medium: Ham's F12 nutrient mixture in a shaking water bath at 37 degrees C for up to 310 min. The viability was determined by the production of beta human chorionic gonadotrophin (HCG) and lactic dehydrogenase (LDH) and the incorporation of [3H]thymidine, [3H]L-leucine and L-[U14C]arginine, while ultrastructure was assessed by transmission electron microscopy. In the first and third trimester group, the release into the medium of the intracellular enzyme LDH remained unaltered throughout the experiment. By contrast, beta-HCG concentrations increased linearly and concentrations were higher in the first trimester than term villi (354.5 +/- 37.8 versus 107 +/- 8.1 IU/g villi protein; P < 0.001). Electron microscopy confirmed preservation of tissue viability for up to 4 h of incubation. The incorporation of thymidine (12.2 +/- 2.9 versus 5.2 +/- 0.5 nmol/g villi protein; P < 0.05), leucine (9.4 +/- 2.1 versus 1.9 +/- 0.4 nmol/g villi protein; P < 0.02) and arginine (17 +/- 4.4 versus 4.2 +/- 0.5 nmol/g villi protein; P < 0.05) were markedly higher in early than in term placenta. Furthermore, placental uptake of L-leucine by the first (9.4 +/- 2.1 versus 17 + 4.4 mol/g villi protein; P < 0.001) and third trimester placental villi (1.9 +/- 0.4 versus 4.2 + 0.5 mol/g villi protein; P < 0.001) was less than that of L-arginine. This study describes a simple technique using placental explants to determine relative rates of uptake of substrate amino acids throughout gestation.  (+info)

Immunity to placental malaria. I. Elevated production of interferon-gamma by placental blood mononuclear cells is associated with protection in an area with high transmission of malaria. (5/382)

In areas in which malaria is holoendemic, primigravidae and secundigravidae, compared with multigravidae, are highly susceptible to placental malaria (PM). The nature of gravidity-dependent immune protection against PM was investigated by measuring in vitro production of cytokines by placental intervillous blood mononuclear cells (IVBMC). The results demonstrated that interferon (IFN)-gamma may be a critical factor in protection against PM: production of this cytokine by PM-negative multigravid IVBMC was elevated compared with PM-negative primigravid and secundigravid and PM-positive multigravid cells. Low IFN-gamma responsiveness to malarial antigen stimulation, most evident in the latter group, was balanced by increased interleukin (IL)-4 production, suggesting that counter-regulation of these two cytokines may be a crucial determinant in susceptibility to PM. A counter-regulatory relationship between IL-10 and tumor necrosis factor-alpha was also observed in response to malarial antigen stimulation. These data suggest that elevated production of IFN-gamma, as part of a carefully regulated cytokine network, is important in the control of PM.  (+info)

Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. (6/382)

Laminins are heterotrimeric molecules composed of an alpha, a beta, and a gamma chain; they have broad functional roles in development and in stabilizing epithelial structures. Here, we identified a novel laminin, composed of known alpha and beta chains but containing a novel gamma chain, gamma3. We have cloned gene encoding this chain, LAMC3, which maps to chromosome 9 at q31-34. Protein and cDNA analyses demonstrate that gamma3 contains all the expected domains of a gamma chain, including two consensus glycosylation sites and a putative nidogen-binding site. This suggests that gamma3-containing laminins are likely to exist in a stable matrix. Studies of the tissue distribution of gamma3 chain show that it is broadly expressed in: skin, heart, lung, and the reproductive tracts. In skin, gamma3 protein is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. The gamma3 chain is also a prominent element of the apical surface of ciliated epithelial cells of: lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma3-containing laminins on the apical surfaces of a variety of epithelial tissues is novel and suggests that they are not found within ultrastructurally defined basement membranes. It seems likely that these apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells.  (+info)

Rapid detection of chromosome aneuploidies by quantitative fluorescence PCR: first application on 247 chorionic villus samples. (7/382)

We report the results of the first major study of applying quantitative fluorescence polymerase chain reaction (QF-PCR) assays for the detection of major chromosome numerical disorders. The QF-PCR tests were performed on a total of 247 chorionic villus samples, which were analysed blind, without any knowledge of the results obtained using conventional cytogenetic analysis. The aims of this investigation were to evaluate the detection power and accuracy of this approach by testing a large number of fetal samples and to assess the diagnostic value of each of the chromosome specific small tandem repeat (STR) markers used. In addition, we introduced three more markers specific for chromosomes 13, 18, and X to allow an accurate analysis of samples homozygous for a particular STR. Fluorescent labelled primers were used to amplify 12 STRs specific for chromosomes 21, 18, 13, X, and the amylogenin-like DNA sequence AMXY, expressed on the X and Y chromosomes. In this blind study of 247 fetal samples, 222 were correctly diagnosed by QF-PCR as normal for each of the five chromosomes investigated; 20 were diagnosed by QF-PCR as trisomic for chromosomes 21, 18, or 13, in agreement with the cytogenetic tests. Only one false negative result was observed, probably owing to the mishandling of the sample, which had been transferred through three laboratories before being analysed by QF-PCR. The 247 samples also included four cases of mosaicism or translocation; one case of mosaic trisomy 21 was detected by QF-PCR and the other cases were not identified by QF-PCR. The results of this investigation provide clear evidence that the QF-PCR assays are powerful adjuncts to conventional cytogenetic techniques and can be applied for the rapid and accurate prenatal diagnosis of the most frequent aneuploidies.  (+info)

Trisomy/tetrasomy 21 mosaicism in CVS: interpretation of cytogenetic discrepancies between placental and fetal chromosome complements. (8/382)

Trisomy/tetrasomy 21 mosaicism was found in chorionic villi (semidirect preparation) obtained from a 40 year old pregnant woman. Since both cell lines were abnormal, the couple elected for pregnancy termination. Placenta and fetal tissue samples were obtained for cytogenetic study. Long term cultured villi showed a non-mosaic trisomy 21 karyotype, while other tissues showed either a normal karyotype or normal/trisomy21 mosaicism. These discrepancies could be explained by a modified "bottle neck" embryogenic model with a trisomic zygote and a non-disjunction event taking place in one of the first divisions. Our case emphasises the need for confirmatory studies in other tissues when mosaicism is encountered in chorionic villi, even if all cell lines are abnormal.  (+info)

Electron J Biomed 2013;2:29-36. Castej n y L pez. PLACENTAL VILLI ASSOCIATED WITH OBESITY AND HYPERTENSI NElectron J Biomed 2013;2:29-36. Castej n y L pez. PLACENTAL VILLI ASSOCIATED WITH OBESITY AND HYPERTENSI N
DISCUSSION In this paper is shown that obesity associate with hypertension produce severe degenerative changes in stem villi and other placental villi. Although no thrombosis was observed in stem villi, it could to be possible that obstructive lumina of the vessels in the chorionic plate leads to villous stromal changes in the placental villi or in the syncytio by reduction of blood flow.Hypertension appears to induce vascular endothelial damage. Maternal hypertension predispose to decresead uteroplacental blood flow which could to stimulate few attracting of blood by intermediate placental villi provoking isquemic placental villi with degenerative changes.The underperfusion of the intervillous space has resulted in local areas with increased perivillous fibrin and villous agglutination. Growing evidence in human and animal models of maternal obesity indicate several placental changes: increased idiopathic villitis, macrophage infiltration and placental vascularity9. A reduction of blood flow in ...
Angiogenic Response of Placental Villi to HeparinAngiogenic Response of Placental Villi to Heparin
To estimate the angiogenic effect of heparin on human umbilical vein endothelial cells cultured in conditioned media from normal and severely pre-eclamptic human placental villi. Normal first- and second-trimester floating placental villi were explanted in control conditions and increasing concentr...
View source for File:HillH52 chorionic villi 08.jpg - EmbryologyView source for File:HillH52 chorionic villi 08.jpg - Embryology
Human Chorionic Villi== Human early placental villi development at 4-5 weeks. (Hill H52, x40) {{HE}} scale bar - 50 μm) Developing villi viewed in cross-section. Trophoblast shell enclosing mesenchyme (extra-embryonic mesoderm), containing embryonic blood vessels. * Trophoblast layer consists of outer syncitiotrophoblast cells and inner cytotrophoblast cells. * Gap between trophoblast and mesenchyme are shrinkage artefacts. {{HillH52}} HillH52slide2x40_13.jpg 24092013 scaled to 1200px [[Category:Trophoblast ...
Cytokine Expression by First-Trimester Human Chorionic Villi - Bennett - 2011 - American Journal of Reproductive Immunology -...Cytokine Expression by First-Trimester Human Chorionic Villi - Bennett - 2011 - American Journal of Reproductive Immunology -...
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Leicester Research Archive: The effect of severity of pre-eclampsia on the basal plate intervillous surface lining components:...Leicester Research Archive: The effect of severity of pre-eclampsia on the basal plate intervillous surface lining components:...
Using immunofluoresce microscopy and histology, intervillous surface lining components area fractions were measured in healthy term chorionic plate (CP) (n=7), healthy term placental basal plate (n=11), mild pre-eclamptic (MPE) placental basal plate (n=10) and severe pre-eclamptic (SPE) placental basal plate (n=11). The aims are (1) to examine the effect of pre-eclampsia (PE) and its severity on the basal plate (BP) intervillous surface lining composition and (2) to define the composition of the CP intervillous surface lining. The results show the mean birth weight of the babies in the SPE are significantly lower than in the HC and MPE (F (2, 29) = 11.912, p =0.000) and the mean gestational age at delivery (GAD) in the SPE group is significantly lower than the HC and MPE (GAD) [Anova p = 0.001; posthoc, p =0.003 and p = 0.001 for MPE and healthy control (HC) respectively]. The mean anchoring villi (AV) to fibrin (NS) ratio of the BP intervillous surface lining is significantly lower in the SPE ...
Interpreting mosaicism in chorionic villi: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up...Interpreting mosaicism in chorionic villi: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up...
The very large presented sample set and consistency in cytogenetic methodology, especially the analysis of both placental layers performed on all CV samples will enable genetic counselors to determine the risk of fetal involvement and the clinical relevance of an identified mosaic condition.
Amniotic Fluid & Chorionic Villus Cells<...Amniotic Fluid & Chorionic Villus Cells<...
Rapid growth and higher metaphase yields with BIs BIO-AMF media for your primary amniotic fluid and chorionic villus cell culturing needs
UPDATE** Placental location and fetal gender - Page 11 - BabyCenterUPDATE** Placental location and fetal gender - Page 11 - BabyCenter
Hello ladies, On my February 2011 birth club (obviously my pregnancy ended in miscarriage), a post about placental location and fetal gender was a hot topic. I thought because we are still in the early stages of pregnancy, I would post this and those who want to update with their results would be fun. ** NOTE: This is considered more of a game. So dont go painting your baby rooms yet :) 97.2% of the male fetuses had a chorionic villi/placenta location on the right side of the uterus. 97.5% of female fetuses had a chorionic villi/placenta location to the left of the uterus. Heres how you read the ultrasound: Tansvaginal ultrasound (Actual result, not a mirror image) If the location of the placenta is on the left of the uterus = girl If the location of the placenta is on the right of the uterus = boy Abdominal ultrasound (Must flip result because it is a mirror image) If the location of the placenta is on the left of the uterus (must flip, its
Plus itPlus it
Our results show that expression and activities of FAO enzymes as well as overall FAO of palmitate and myristate are substantial in human placental villi during gestation and identify trophoblast components as the primary FAO sites in the term placenta. Expression of FAO enzymes and measured activities at lower gestational ages of 12-28 wk are comparable to that in mature slow skeletal muscle, a tissue that uses fatty acids as a substrate to satisfy high energy requirements. The data provide direct evidence that fatty acids undergo extensive mitochondrial β-oxidation in the placenta. Our major conclusion is that fatty acids are utilized as a significant metabolic fuel and energy source in this organ, consistent with our hypothesis. This overall conclusion is novel and at variance with the current concept that glucose is the sole energy source in the placenta (14,16). On the basis of this conclusion, we speculate that human placental mitochondrial FAO is critical for normal growth and maturation ...
Items where Department is Faculty of Health and Medicine | Medicine and Year is 1979 - Lancaster EPrintsItems where Department is "Faculty of Health and Medicine | Medicine" and Year is 1979 - Lancaster EPrints
Clint, J M and Wakely, J and Ockleford, C D (1979) Differentiated regions of human placental cell surface associated with attachment of chorionic villi, phagocytosis of maternal erythrocytes and syncytiotrophoblast repair. Proceedings of the Royal Society of London. Series B, 204 (1156). pp. 345-353. ISSN 0080-4649. OCKLEFORD, C D and CLINT, J M (1979) UPTAKE OF [IGG-H-3 INTO HUMAN-PLACENTA. Journal of Anatomy, 129 (6). p. 883. ISSN 0021-8782. OCKLEFORD, C D and DEVOY, K and HALL, H M K (1979) A Markham rotation enhancement of two polygon types from isolated negatively stained human placental coated vesicles. Cell Biology International Reports, 3 (9). pp. 717-724. ISSN 0309-1651. ...
NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)
Chorionic villus sampling (CVS) is a prenatal test that involves taking a sample of tissue from the placenta, a structure in the uterus that provides blood and nutrients from the mother to the fetus, to test for chromosomal abnormalities and certain other genetic problems.. The chorionic villi are tiny projections of placental tissue that look like fingers and contain the same genetic material as the fetus. Testing may be available for other genetic defects and disorders depending on the family history and availability of lab testing at the time of the procedure.. CVS is usually performed between the 10th and 12th weeks of pregnancy. Unlike amniocentesis (another type of prenatal test), CVS does not provide information on neural tube defects, such as spina bifida. For this reason, women who undergo CVS also need a follow-up blood test between 16 to 18 weeks of their pregnancy to screen for neural tube defects.. There are two types of CVS procedures:. ...
NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)
Chorionic villus sampling (CVS) is a prenatal test that involves taking a sample of tissue from the placenta, a structure in the uterus that provides blood and nutrients from the mother to the fetus, to test for chromosomal abnormalities and certain other genetic problems.. The chorionic villi are tiny projections of placental tissue that look like fingers and contain the same genetic material as the fetus. Testing may be available for other genetic defects and disorders depending on the family history and availability of lab testing at the time of the procedure.. CVS is usually performed between the 10th and 12th weeks of pregnancy. Unlike amniocentesis (another type of prenatal test), CVS does not provide information on neural tube defects, such as spina bifida. For this reason, women who undergo CVS also need a follow-up blood test between 16 to 18 weeks of their pregnancy to screen for neural tube defects.. There are two types of CVS procedures:. ...
Chorionic villus sampling | Radiology Reference Article | Radiopaedia.orgChorionic villus sampling | Radiology Reference Article | Radiopaedia.org
Chorionic villus sampling (CVS) is an antenatal procedure for prenatal diagnosis of chromosomal or genetic disorders in the fetus. It entails getting a sample of the chorionic villus (placental tissue) and testing it. A transabdominal or transce...
Chorionic villus samplingChorionic villus sampling
... (CVS) refers to a procedure in which small samples of the placenta are obtained for prenatal genetic diagnosis, generally in the first trimester after 10 weeks of gestation. CVS results are available earlier in pregnancy tha
Chorionic Villus Sampling (CVS) | Diagnostic Center for WomenChorionic Villus Sampling (CVS) | Diagnostic Center for Women
Chorionic villus sampling is usually done during the first trimester of pregnancy to determine any genetic disorders the baby may have. A thin tube is guided through the cervix or a needle is inserted into the uterus to remove a sample of cells that contain genetic information from the placenta. ...
CVS Test: Chorionic Villus SamplingCVS Test: Chorionic Villus Sampling
What is CVS? Find out what a chorionic villus sampling prenatal test looks for and how its performed to help you decide if the CVS procedure is right for you.
Chromosome Analysis, Chorionic Villus Sampling (CVS)Chromosome Analysis, Chorionic Villus Sampling (CVS)
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
Monoclonal antibody GB25 recognizes human villous trophoblasts. - Semantic ScholarMonoclonal antibody GB25 recognizes human villous trophoblasts. - Semantic Scholar
A monoclonal antibody GB25 which was raised against placental syncytiotrophoblast reacted specifically with villous trophoblasts. It recognized syncytiotrophoblast, villous cytotrophoblasts of the first-trimester placentae, and a majority of the cytotrophoblasts in the chorion laeve, but not the residual cells of cytotrophoblastic shell in the basal plates and the cells in the cytotrophoblastic columns. This antibody will be useful for isolating and differentiating villous from extravillous cytotrophoblasts in the first-trimester placentae.
Chorionic Villus Sampling (CVS) Brookline, MAChorionic Villus Sampling (CVS) Brookline, MA
You will take off your clothes below the waist. You will have a paper or cloth covering around your waist. You will lie on your back on an exam table with your feet raised and supported by stirrups.. Your doctor will put a special tool with curved sides (speculum) into your vagina. The speculum gently spreads apart the vaginal walls. This lets the doctor see the inside of the vagina and the cervix. The cervix will be cleaned with a special soap.. Your doctor will use ultrasound to guide a thin tube (catheter) through your cervix to the placenta. Gel will be rubbed on your belly. An ultrasound device (transducer) will be moved over your belly. It gives off and picks up sound waves. The sound waves are sent to a computer to make a picture of your uterus, your baby, and the placenta. The doctor can also use ultrasound to check your babys heart rate. For more information, see the topic Fetal Ultrasound.. When the catheter is in the right place, a sample of chorionic villus cells will be ...
Chorionic Villi SamplingChorionic Villi Sampling
... Some people have basic questions about how pregnancy happens. Some may have questions about avoiding a pregnancy
Non-mosaic trisomy 20 of paternal origin in chorionic villus and amniotic fluid also detected in fetal blood and other tissues<...Non-mosaic trisomy 20 of paternal origin in chorionic villus and amniotic fluid also detected in fetal blood and other tissues<...
TY - JOUR. T1 - Non-mosaic trisomy 20 of paternal origin in chorionic villus and amniotic fluid also detected in fetal blood and other tissues. AU - Costa-Borges, N.. AU - González, S.. AU - Santaló, J.. AU - Ibañez, E.. AU - Catala Cahis, Vicenç. PY - 2010/1/1. Y1 - 2010/1/1. M3 - Article. VL - 53. SP - 197. EP - 200. JO - European Journal of Medical Genetics. JF - European Journal of Medical Genetics. SN - 1769-7212. ER - ...
Hypoxia-activated genes from early placenta are elevated in Preeclampsia, but not in Intra-Uterine Growth Retardation | BMC...Hypoxia-activated genes from early placenta are elevated in Preeclampsia, but not in Intra-Uterine Growth Retardation | BMC...
As a first step to explore the possible relationships existing between the effects of low oxygen pressure in the first trimester placenta and placental pathologies developing from mid-gestation, two subtracted libraries totaling 2304 cDNA clones were constructed. For achieving this, two reciprocal suppressive/subtractive hybridization procedures (SSH) were applied to early (11 weeks) human placental villi after incubation either in normoxic or in hypoxic conditions. The clones from both libraries (1440 hypoxia-specific and 864 normoxia-specific) were spotted on nylon macroarrays. Complex cDNAs probes prepared from placental villi (either from early pregnancy, after hypoxic or normoxic culture conditions, or near term for controls or pathological placentas) were hybridized to the membranes. Three hundred and fifty nine clones presenting a hybridization signal above the background were sequenced and shown to correspond to 276 different genes. Nine of these genes are mitochondrial, while 267 are nuclear.
Cytotrophoblast - WikipediaCytotrophoblast - Wikipedia
The cytotrophoblast (or layer of Langhans) is the inner layer of the trophoblast. It is interior to the syncytiotrophoblast and external to the wall of the blastocyst in a developing embryo. The cytotrophoblast is considered to be the trophoblastic stem cell because the layer surrounding the blastocyst remains while daughter cells differentiate and proliferate to function in multiple roles. There are two lineages that cytotrophoblastic cells may differentiate through: fusion and invasive. The fusion lineage yields syncytiotrophoblast and the invasive lineage yields interstitial cytotrophoblast cells. Cytotrophoblastic cells play an important role in the implantation of a newly fertilized egg in the uterus. The formation of all syncytiotrophoblast is from the fusion of two or more cytotrophoblasts via this fusion pathway. This pathway is important because the syncytiotrophoblast plays an important role in fetal-maternal gas exchange, nutrient exchange, and immunological and metabolic functions. ...
ProfileProfile
Hemochorial placentation, with placental villi bathing in maternal blood, entails direct contact of circulating maternal leukocytes with the fetal trophoblast, ,nobr,i. e.,/nobr, the syncytiotrophoblast, which covers all placental villous trees as well as parts of the inner surfaces of chorionic and basal plates (1). This way, placenta-derived factors, such as hormones and cytokines predominantly released by the syncytio-trophoblast, may influence circulating maternal blood cells and vice versa factors from maternal leukocytes may regulate villous trophoblast functions. Thus, a combination of modulating signals and responses between maternal circulating blood cells and the placental trophoblast may dynamically be adjusted over gestation for an overall cooperative microenvironment in the intervillous space. Alterations in this cooperative microenvironment may occur very early in pregnancy and is suggested to program early placenta functions and growth long before any phenotypic changes become ...
Most recent papers with the keyword Maternal-fetal | Read by QxMDMost recent papers with the keyword Maternal-fetal | Read by QxMD
We aimed to investigate the expression of suppressors cytokine signaling (SOCS)-3, transforming growth factor (TGF)-β and indoleamine 2,3-dioxygense (IDO) and to analyse the relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua in the maternal-fetal interface. Western blot analysis and immunohistochemical method were used to detect the expression of TGF-β, SOCS3 and IDO in chorionic villi and decidua tissues of normal pregnant women. SOCS3, TGF-β and IDO protein was identified in chorionic villi and decidua tissues of normal pregnant women and there was a negative correlation between the expression of IDO and SOCS3, but TGF-β expression was positively correlated with IDO expression ...
Most recent papers with the keyword Indoleamin | Read by QxMDMost recent papers with the keyword Indoleamin | Read by QxMD
We aimed to investigate the expression of suppressors cytokine signaling (SOCS)-3, transforming growth factor (TGF)-β and indoleamine 2,3-dioxygense (IDO) and to analyse the relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua in the maternal-fetal interface. Western blot analysis and immunohistochemical method were used to detect the expression of TGF-β, SOCS3 and IDO in chorionic villi and decidua tissues of normal pregnant women. SOCS3, TGF-β and IDO protein was identified in chorionic villi and decidua tissues of normal pregnant women and there was a negative correlation between the expression of IDO and SOCS3, but TGF-β expression was positively correlated with IDO expression ...
BMJ Best PracticeBMJ Best Practice
In this monograph we refer to all varieties of invasive placentation as abnormally adherent placenta. There are 3 commonly defined variants: placenta accreta (where chorionic villi attach to the myometrium, rather than being restricted within the decidua basalis), placenta increta (where the chorionic villi invade into the myometrium), and placenta percreta (where the chorionic villi invade through the myometrium and sometimes into adjoining tissue). [1] Publications Committee, Society for Maternal-Fetal Medicine, Belfort MA. Placenta accreta. Am J Obstet Gynecol. 2010;203:430-439. http://www.ncbi.nlm.nih.gov/pubmed/21055510?tool=bestpractice.com Although these distinctions are important to consultants, they do not change management decisions for primary care providers. ...
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The distribution of mRNAs and antigens of tissue type (t) and urokinase type (u) plasminogen activators (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) were studied in human and rhesus monkey placentae by in situ hybridisation and immunocytochemistry. Specific monkey cRNA and antibodies against human tPA, uPA, PAI-1 and PAI-2 were used as probes. The following results were obtained. (1) All the molecules tPA, uPA, PAI-1 and PAI-2 and their mRNAs were identified in the majority of the extravillous cytotrophoblast cells of the decidual layer between Rohrs and Nitabuchs striae and in cytotrophoblast cells of the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (2) Expression of uPA and PAI-2 was noted in villous trophoblast whereas tPA and PAI-1 were mainly concentrated where detachment from maternal tissue occurs. (3) No expression of tPA, uPA, PAI-1 and PAI-2 was observed in the basal plate endometrial ...
Purification of human cytotrophoblast from term amniochorion by flow cytometry. - Nuffield Department of Obstetrics and...Purification of human cytotrophoblast from term amniochorion by flow cytometry. - Nuffield Department of Obstetrics and...
Term cytotrophoblast do not express polymorphic MHC Class I antigens, unlike other fetal and maternal cells in the amniochorion/decidua. This allows cytotrophoblast to be isolated and purified from this tissue, utilizing 4E, a monoclonal antibody specific for HLA-B, which labels only non-trophoblast. We have developed a method using enzymic dispersion and Percoll gradient centrifugation, followed by flow cytometry, that yields, on average, a total of 5 X 10(6) term extravillous cytotrophoblast, 97 per cent pure. The availability of highly purified extravillous cytotrophoblast, for the first time, permits precise investigation of trophoblast function.
CMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus SamplingCMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling
CMAP : Prenatal diagnosis of copy number changes (gains or losses) across the entire genome   Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected by other methods such as conventional chromosome and fluorescence in situ hybridization (FISH) studies   Determining if apparently balanced abnormalities identified by previous conventional chromosome studies have cryptic imbalances, since a proportion of such rearrangements that appear balanced at the resolution of a chromosome study are actually unbalanced when analyzed by higher-resolution chromosomal microarray   Assessing regions of homozygosity related to uniparental disomy or identity by descent
CMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus SamplingCMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling
CMAP : Prenatal diagnosis of copy number changes (gains or losses) across the entire genome   Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected by other methods such as conventional chromosome and FISH studies   Determining if apparently balanced abnormalities identified by previous conventional chromosome studies have cryptic imbalances, since a proportion of such rearrangements that appear balanced at the resolution of a chromosome study are actually unbalanced when analyzed by higher-resolution chromosomal microarray   Assessing regions of homozygosity related to uniparental disomy or identity by descent
The Study Of Relation ship Between The Maturation Abnormalities Of Placenta And Late lntra uterine Fetal DeathThe Study Of Relation ship Between The Maturation Abnormalities Of Placenta And Late lntra uterine Fetal Death
This study was done on 60 pregnant women that have case intra uterine fetal death in kerbala city. We determined the placental abnormalities that lead to intra uterine fetal death through histopathological sections. The resulting shown six groups of cases with defective placental maturation .The first group of cases shown absence of syncytio-vascular membrane formation and the second group shown immaturity and hydropic degeneration of chorionic villi. The third group shownchronic villitis and the fourth shown fibrin depositions and loss of vessels in the villous stroma of placenta .The fifth group shown foetal thrombotic lesions which consist of large groups of vascular fibrotic villi as the result of vessel thrombosis .The last group shown umbilical cord abnormal coiling (over coiling) or under coiling . These groups of cases represent the most important causes of late intra utrine fetal death.
Prenatal | Irvine ScientificPrenatal | Irvine Scientific
Chorionic Villus Sampling (CVS) is a form of prenatal diagnosis to determine chromosomal or genetic disorders in the fetus. CVS entails the sampling of the chorionic villus (placental tissue), and then testing it for chromosomal abnormalities, usually with FISH or PCR.. ...
LM of blood vessels in villi of small intestine - Stock Image P520/0080 - Science Photo LibraryLM of blood vessels in villi of small intestine - Stock Image P520/0080 - Science Photo Library
Capillaries in intestinal villi. Light micrograph of a transverse section through villi in the small intestine, showing the blood supply. At bottom are the outer muscle layers in the wall of the small intestine. Villi are finger-like projections on the inner wall, which face the lumen (at top). The villi are adapted for the absorption of digested food. The core of each villus contains blood capillaries (dark), which here have been injected to highlight their structure. Epithelial cells on the surface of each villus absorb food, which is then passed into the bloodstream through this capillary system. The 6 metre long human small intestine contains thousands of villi. - Stock Image P520/0080
Double X Science: Pregnancy 101: My placenta looked like meatloaf, but I wasnt about to eat it.Double X Science: Pregnancy 101: My placenta looked like meatloaf, but I wasn't about to eat it.
These tree-like masses originating from the umbilical cord (and thus fetus) sit in a cavity called the intervillous space, and are bathed in nutrient-rich maternal blood. This maternal blood, which provides the fetus with a means for both nutrient delivery and waste elimination, is continually replenished via a network of maternal arteries and veins that feed into the intervillous space. Furthermore, these arteries and veins help to anchor the placenta into the uterine wall. One of the most interesting aspects about the mother-feus relationship is that the blood vessel connection is indirect. This helps to prevent a detrimental immune response, which could lead to immunological rejection of the fetus (sort of like how a transplanted organ can become rejected by the recipient ...
Still waiting for CVS full Results!!!! - BabyCentreStill waiting for CVS full Results!!!! - BabyCentre
Hi I feel like I am losing my mind, still waiting for our full CVS (Chorionic Villus Sampling) results and it has been 2 weeks. Just rang the clinic who now said it can be 2 - 3 weeks! Really dont think I can take another week of all this waiting, what can be taking so long, just want to know that all is ok so we can book the heart scan. This is the worst 2 weeks ever. Is anyone else waiting for results? Sam
October 1994 | 1994 | Fetal sampling: poor track record | October | 1994 | News | What Doctors Dont Tell YouOctober 1994 | 1994 | Fetal sampling: poor track record | October | 1994 | News | What Doctors Don't Tell You
Chorionic villus sampling (CVS) is not only a dangerous test in fetuses older than nine weeks when it was assumed to be the safest period for testing but carries a high risk of inaccuracy
Analysis of function and regulation of progranulin and miR-195 on human villous trophoblast cells and its impact on endothelial...Analysis of function and regulation of progranulin and miR-195 on human villous trophoblast cells and its impact on endothelial...
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Intestinal villus - WikipediaIntestinal villus - Wikipedia
There, the villi and the microvilli increase intestinal absorptive surface area approximately 30-fold and 600-fold, respectively, providing exceptionally efficient absorption of nutrients in the lumen.[2]. There are also enzymes (enterocyte digestive enzyme) on the surface for digestion. Villus capillaries collect amino acids and simple sugars taken up by the villi into the blood stream. Villus lacteals (lymph capillary) collect absorbed chylomicrons, which are lipoproteins composed of triglycerides, cholesterol and amphipathic proteins, and are taken to the rest of the body through the lymph fluid. Villi are specialized for absorption in the small intestine as they have a thin wall, one cell thick, which enables a shorter diffusion path. They have a large surface area so there will be more efficient absorption of fatty acids and glycerol into the blood stream. They have a rich blood supply to keep a concentration gradient.[3]. ...
Refubium - Die Expression der EGF-Rezeptor-Familie (HER-1, HER-2, HER-3, HER-4) im extravillösen Trophoblasten im Vergleich...Refubium - Die Expression der EGF-Rezeptor-Familie (HER-1, HER-2, HER-3, HER-4) im extravillösen Trophoblasten im Vergleich...
Pregnancy induced hypertension (PIH) is a significant problem in maternal medicine. According to recent publications, insufficient invasion of extravillous trophoblasts into the myometrial parts of the spiral arteries may be responsible for this. The vessel inadequately adapts to the increased perfusion uterus need during pregnancy and consequently, multiple vasodilatory mediators are released. This results in the clinical picture of endothelial dysfunction with hypertension, proteinuria and oedema. The reason of this inadequate invasion of trophoblasts is unknown. In order to identify the causative factors, we hypothesise that the trophoblasts invasion at the beginning of pregnancy is comparable with the growth of malignant tumours.The invasion of extravillous trophoblasts shows a breach of basal membranes and invasive growth. Therefore, growth factors and their receptors, in particular those of the EGF family could play a central role. They have already been researched extensively in relation ...
chorio - Search results on GenericLook.comchorio - Search results on GenericLook.com
also filters for plasma nutrients and wastes. The uterine arteries carry oxygenated blood to the placenta and permeate the sponge-like material there. Oxygen then diffuses from the placenta to the chorionic villus and then to the umbilical vein. What is the mechanism of fetal circulation? In fetal circulation, the placenta, through the umbilical vein, carries blood to the fetus. The umbilical ...
Prenatal Genetic Screening Tests - American Family PhysicianPrenatal Genetic Screening Tests - American Family Physician
Some screening tests are done in the first trimester of pregnancy, and some are done in the second trimester. Your doctor may have you tested in both trimesters, depending on your babys risk and the testing method you select.. There are several ways to do the screening. One type of screening (no needles) is an ultrasound. This measures the thickness of the liquid under the skin on your babys neck. If the thickness is not normal, your baby may not have the normal number of chromosomes. Your doctor may also do a blood test to check your babys risk of having a genetic disorder.. There are two tests that can say for sure if your baby has a genetic disorder. They both have a small risk of causing a miscarriage. One test is called amniocentesis (AM-nee-oh-sen-TEE-sis). This is when the doctor uses a needle to take a small sample of fluid from the bag of water around the baby. The other test is called chorionic villus (core-ee-AH-nick VIL-us) sampling. This is when the doctor uses a needle to take a ...
UAB - School of Medicine - Genetics - Clinical LabsUAB - School of Medicine - Genetics - Clinical Labs
The Cytogenetics Laboratory performs chromosome analysis, fluorescence in situ hybridization (FISH), and array comparative genomic hybridization (array CGH) on cells prepared from a wide variety of tissues including amniotic fluid, chorionic villi, products of conception, peripheral blood leukocytes, bone marrow, lymph node, and skin/muscle biopsy.. Learn more. ...
October 18, 2012 | DNA Science BlogOctober 18, 2012 | DNA Science Blog
When I was a fetus, I was left alone. My amniotic fluid and chorionic villi were untouched, and I arrived apparently normal, except for a mark on the part of my anatomy where a bullet. ...
Intestinal villi, SEM - Stock Image C004/6481 - Science Photo LibraryIntestinal villi, SEM - Stock Image C004/6481 - Science Photo Library
Intestinal villi. Coloured scanning micrograph (SEM) of villi (rounded folds) in the jejunum (part of the small intestine). Villi are finger-like projections in the intestines that increase the surface area available for the absorption of nutrients. Traces of mucus (purple) are seen between the villi (pink). Magnification: x90 when printed at 10 centimetres across. - Stock Image C004/6481
OriGene - CALCA (NM 001033952) cDNA CloneOriGene - CALCA (NM 001033952) cDNA Clone
CALCA - CALCA (untagged)-Human calcitonin-related polypeptide alpha (CALCA), transcript variant 2 available for purchase from OriGene - Your Gene Company.
Building Applications With The Vue 3 Composition API - GenuitecBuilding Applications With The Vue 3 Composition API - Genuitec
One of the features Vue 3 is bringing is the Composition API which is a differentiation from the traditional Vue 2 Options API. Lets understand the Composition API building a To-Do Application
VUe to visulize biological processes and interactionsVUe to visulize biological processes and interactions
If this is your first visit to the new VUE forums, you can login using the same username and password you currently use on VUEs website. If you need an account, please create one through VUEs website. If you have problems, please contact us via the contact form on http://vue.tufts.edu ...
Varilux X series Everything you need to know about this new progressive lens | Points de Vue | International Review of...Varilux X series Everything you need to know about this new progressive lens | Points de Vue | International Review of...
Refer this content as: Points de Vue International Review of Ophthalmic Optics, Varilux X series Everything you need to know about this new progressive lens, online publication, www.pointsdevue.com, September 2017. ...
ejs-calendar multiple values gone | Vue Forums | Syncfusionejs-calendar multiple values gone | Vue Forums | Syncfusion
Join now and share your views and answers on Syncfusion Developer Community for the thread: Vue - ejs-calendar multiple values gone
Webpack ReferenceError: process is not defined · Issue #871 · SimulatedGREG/electron-vue · GitHubWebpack ReferenceError: process is not defined · Issue #871 · SimulatedGREG/electron-vue · GitHub
Issue Fresh electron-vue project gives webpack error: ReferenceError: process is not defined Look like issue #516 solved by #726 for build:web Reproduction vue init simulatedgreg/electron-vue test_vue_error cd test_vue_error npm install ...
How to find string in a cell/column with formulas in Excel?How to find string in a cell/column with formulas in Excel?
Office Tab brings you the tabs in Office, Classic Menu brings back the office 2003 menu tools, Kutools for excel brings you the powerful Excel tools, we bring you the professional Office add-ins.
How to find string in a cell/column with formulas in Excel?How to find string in a cell/column with formulas in Excel?
Office Tab brings you the tabs in Office, Classic Menu brings back the office 2003 menu tools, Kutools for excel brings you the powerful Excel tools, we bring you the professional Office add-ins.
STAR - a typical error, many fixes triedSTAR - a typical error, many fixes tried
Hi Friederike! We tried a contact with bioinformatics support of Ion, and they told us that we could do it and recommended to separate our reads with samtools. We tried it again, without any success and different suggestion from support. I proceeded to a depth calculation in samtools itself and i cant see the CALCA here. You know, my coverage was not 100%, some reads was lost as machine output shows (60-70% of useful reads) maybe this is just the case. There is no way to recover because (for some reason) the primer, machine or pipeline of the version that we made use failed.. flagstat statistics 5467132 + 0 in total (QC-passed reads + QC-failed reads) 5457323 + 0 mapped (99.82% : N/A). As you see, my .BAM is fine. I have different numbers of genes with zero counts depending of libraries, but all of them have zero with CALCA. I tried to navigate my bam in R, exported by view , bam.txt function. I have everything that i need: genes coordinate, ID, cigar, reads...but CALCA is not here. I tried to ...
In the Pipes: Import Intergraph Smart™ / SmartPlant® 3D models to NavisworksIn the Pipes: Import Intergraph Smart™ / SmartPlant® 3D models to Navisworks
For those of you who have been looking for a way to open Intergraph VUE files directly in Navisworks, there is an Autodesk Labs project that may interest you. Viewing Intergraph Smart™ / SmartPlant 3D® VUE files in Autodesk Navisworks...
Altri Comuni - LA ROCHE BLANCHE - Le Plateau de GERGOVIE - extrémité Ouest vue du col des Goules1950- bon étatAltri Comuni - LA ROCHE BLANCHE - Le Plateau de GERGOVIE - extrémité Ouest vue du col des Goules1950- bon état
minaire vende al prezzo di 3,00 € fino al mercoledì 8 luglio 2020 19:04:00 CEST un oggetto nella categoria Altri Comuni di Delcampe
Motivation at Zachman Row 1 (Features)Motivation at Zachman Row 1 (Features)
John Zachmans Framework for Enterprise Architecture is a matrix that is widely used in describing and defining the various interrelated elements of the enterprise and its systems. One of the important efforts over the twenty years since the introduction of the Zachman Framework for Enterprise Architecture has been the definition of each of its cells. In this months feature, Allan Kolber shares his perspective on the model for Motivation cell (column six) at Zachman row one.
Uterine glandUterine gland
Hofbauer cellHofbauer cell
Gestational hypertensionGestational hypertension
Placenta accretaPlacenta accreta
TrophoblastTrophoblast
Confined placental mosaicismConfined placental mosaicism
Ring 18Ring 18
Placental villous immaturityPlacental villous immaturity
Hemolytic disease of the newborn (anti-Kell)Hemolytic disease of the newborn (anti-Kell)
Sex-selective abortionSex-selective abortion
Prenatal sex discernmentPrenatal sex discernment
Tay-Sachs diseaseTay-Sachs disease
Prevention of Tay-Sachs diseasePrevention of Tay-Sachs disease
Prenatal testingPrenatal testing
PlacentationPlacentation
List of bacterial vaginosis microbiotaList of bacterial vaginosis microbiota
Implantation (human embryo)Implantation (human embryo)
Percutaneous umbilical cord blood samplingPercutaneous umbilical cord blood sampling
Distal 18q-Distal 18q-
18p-18p-
Proximal 18q-Proximal 18q-
CVSCVS
Interleukin 11Interleukin 11
ChoriocarcinomaChoriocarcinoma
AmniocentesisAmniocentesis
Jan MohrJan Mohr
Schindler diseaseSchindler disease
MiscarriageMiscarriage
Miscarriage risksMiscarriage risks
SequenomSequenom
Elective genetic and genomic testingElective genetic and genomic testing
Neonatal diabetes mellitusNeonatal diabetes mellitus
BandicootBandicoot
Pregnancy (mammals)Pregnancy (mammals)
HMOX2HMOX2
Villitis of unknown etiologyVillitis of unknown etiology
Trisomy 16Trisomy 16
ChorangiosisChorangiosis
Opportunistic infectionOpportunistic infection
Triple X syndromeTriple X syndrome
Turner syndromeTurner syndrome
Tetrasomy 18pTetrasomy 18p
MarsupialMarsupial
Smith-Lemli-Opitz syndromeSmith-Lemli-Opitz syndrome
Genetic studies on ArabsGenetic studies on Arabs
Decidua menstrualisDecidua menstrualis
Axenfeld syndromeAxenfeld syndrome
Neurofibromatosis type INeurofibromatosis type I
Genetic testingGenetic testing
Cell-free fetal DNACell-free fetal DNA
IsomeraseIsomerase
Visceral leishmaniasisVisceral leishmaniasis
Umbilical veinUmbilical vein
UK National Screening CommitteeUK National Screening Committee
AneuploidyAneuploidy
Fetal-maternal haemorrhageFetal-maternal haemorrhage
Kleihauer-Betke testKleihauer-Betke test
Ravinder DhallanRavinder Dhallan
LissencephalyLissencephaly
Glycogen storage disease type IGlycogen storage disease type I
Vacuum aspirationVacuum aspiration
Human embryogenesisHuman embryogenesis
Molar pregnancyMolar pregnancy
Hunter syndromeHunter syndrome
Constriction ring syndromeConstriction ring syndrome
Spinal muscular atrophySpinal muscular atrophy
ChorionChorion
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Trisomy 9Trisomy 9
Alström syndromeAlström syndrome
BYSLBYSL
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Down syndromeDown syndrome
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MTRR (gene)MTRR (gene)
Yvonne ThorntonYvonne Thornton
Saethre-Chotzen syndromeSaethre-Chotzen syndrome
Nuchal scanNuchal scan
Craniofrontonasal dysplasiaCraniofrontonasal dysplasia
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Fetal thrombotic vasculopathyFetal thrombotic vasculopathy
CytotrophoblastCytotrophoblast
Familial dysautonomiaFamilial dysautonomia
X-linked severe combined immunodeficiencyX-linked severe combined immunodeficiency
7-Dehydrocholesterol reductase7-Dehydrocholesterol reductase
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Down syndromeDown syndrome
Jansky-Bielschowsky diseaseJansky-Bielschowsky disease
Placental infarctionPlacental infarction
NFE2L3NFE2L3
DNA paternity testingDNA paternity testing
Pallister-Killian syndromePallister-Killian syndrome
Fragile X syndromeFragile X syndrome
Yury VerlinskyYury Verlinsky
Single umbilical arterySingle umbilical artery
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Predictive medicinePredictive medicine
Lamaze techniqueLamaze technique
Outline of obstetricsOutline of obstetrics
Gugur kandungan bahasa Indonesia, ensiklopedia bebasGugur kandungan bahasa Indonesia, ensiklopedia bebas
Medical geneticsMedical genetics
ChorionChorion
থ্যালাসেমিয়া - উইকিপিডিয়াথ্যালাসেমিয়া - উইকিপিডিয়া
డౌన్ సిండ్రోమ్ - వికీపీడియాడౌన్ సిండ్రోమ్ - వికీపీడియా
සිසේරියානු සැත්කම - විකිපීඩියා, නිදහස් විශ්වකෝෂයසිසේරියානු සැත්කම - විකිපීඩියා, නිදහස් විශ්වකෝෂය
Yvonne ThorntonYvonne Thornton
Obstetrics and gynaecologyObstetrics and gynaecology
Selective reductionSelective reduction
Ring 18Ring 18
GalactosemiaGalactosemia
ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ - ವಿಕಿಪೀಡಿಯಶಸ್ತ್ರಚಿಕಿತ್ಸೆ - ವಿಕಿಪೀಡಿಯ
Amniotic fluidAmniotic fluid
PregnancyPregnancy
PelvimetryPelvimetry
Klinefelter syndromeKlinefelter syndrome
Unintended pregnancyUnintended pregnancy
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Avisî - WîkîpediyaAvisî - Wîkîpediya
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Congenital adrenal hyperplasia due to 21-hydroxylase deficiencyCongenital adrenal hyperplasia due to 21-hydroxylase deficiency
Gestational pemphigoidGestational pemphigoid
Sindrom Down Bahasa Melayu, ensiklopedia bebasSindrom Down Bahasa Melayu, ensiklopedia bebas
Obstetrical forcepsObstetrical forceps
Vaginal deliveryVaginal delivery
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Index of anatomy articlesIndex of anatomy articles
Sybil ShainwaldSybil Shainwald
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Karin J. BlakemoreKarin J. Blakemore
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Joseph D. SchulmanJoseph D. Schulman
Fetal hemoglobinFetal hemoglobin
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Chorionic VilliChorionic Villi SamplingPrenatal DiagnosisAmniocentesisPregnancy Trimester, FirstPregnancyTrophoblastsPlacentaFetal DiseasesChromosome DisordersFetomaternal TransfusionKaryotypingPregnancy, TubalGestational AgeUltrasonography, PrenatalAbortion, SpontaneousMethemalbuminChorionTrisomyAmniotic FluidPlacentationDown SyndromeCordocentesisPregnancy, High-RiskMaternal AgeMosaicismAmnionAneuploidyHydatidiform MoleNeckAbortion, EugenicChromosome AberrationsDeciduaAbortion, SepticCrown-Rump LengthPregnancy Reduction, MultifetalPregnancy Trimester, SecondFetusNuchal Translucency MeasurementPregnancy, MultipleIntestine, SmallPre-EclampsiaPregnancy Trimester, ThirdJejunumGenetic CounselingIntestinal Mucosabeta-ThalassemiaAbortion, InducedPregnancy OutcomeChoriocarcinomaLeukemia Inhibitory Factor Receptor alpha SubunitMicrovilliHeterozygote DetectionChromosomes, Human, Pair 18IleumFetal DeathAbnormalities, MultipleBasement MembraneImmunohistochemistryFluorescent Antibody Technique
Cytokine Expression by First-Trimester Human Chorionic Villi - Bennett - 2011 - American Journal of Reproductive Immunology -...Cytokine Expression by First-Trimester Human Chorionic Villi - Bennett - 2011 - American Journal of Reproductive Immunology -...
Amniotic Fluid & Chorionic Villus Cells<...Amniotic Fluid & Chorionic Villus Cells<...
Interpreting mosaicism in chorionic villi: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up...Interpreting mosaicism in chorionic villi: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up...
Plus itPlus it
Leicester Research Archive: The effect of severity of pre-eclampsia on the basal plate intervillous surface lining components:...Leicester Research Archive: The effect of severity of pre-eclampsia on the basal plate intervillous surface lining components:...
Chorionic villi - WikipediaChorionic villi - Wikipedia
Chorionic villus sampling - WikipediaChorionic villus sampling - Wikipedia
Chorionic Villus Sampling | Encyclopedia.comChorionic Villus Sampling | Encyclopedia.com
Chorionic villus samplingChorionic villus sampling
Chorionic Villi SamplingChorionic Villi Sampling
Chorionic villus sampling: MedlinePlus Medical Encyclopedia ImageChorionic villus sampling: MedlinePlus Medical Encyclopedia Image
Chorionic villus sampling - series-Results: MedlinePlus Medical EncyclopediaChorionic villus sampling - series-Results: MedlinePlus Medical Encyclopedia
Chorionic Villus Sampling: Purpose, Procedure & RisksChorionic Villus Sampling: Purpose, Procedure & Risks
Chromosome Analysis, Chorionic Villus Sampling (CVS)Chromosome Analysis, Chorionic Villus Sampling (CVS)
Chorionic Villus Sampling for Prenatal Diagnosis | EmaxHealthChorionic Villus Sampling for Prenatal Diagnosis | EmaxHealth
Pregnancy - Pregnancy Topics - Chorionic Villus Sampling (CVS)Pregnancy - Pregnancy Topics - Chorionic Villus Sampling (CVS)
CVS (chorionic villus sampling) - BioNewsCVS (chorionic villus sampling) - BioNews
Chorionic villus sampling - definition of chorionic villus sampling by The Free DictionaryChorionic villus sampling - definition of chorionic villus sampling by The Free Dictionary
Prenatal Test: Chorionic Villus Sampling (CVS) (for Parents) - Hospital Sant Joan de DeuPrenatal Test: Chorionic Villus Sampling (CVS) (for Parents) - Hospital Sant Joan de Deu
CVS Test: Chorionic Villus SamplingCVS Test: Chorionic Villus Sampling
Chorionic Villus Sampling -- Transcervical | Portsmouth HospitalChorionic Villus Sampling -- Transcervical | Portsmouth Hospital
Chorionic Villus Sampling (CVS) | Main Line Health | Philadelphia, PennsylvaniaChorionic Villus Sampling (CVS) | Main Line Health | Philadelphia, Pennsylvania
Fetal karyotyping by chorionic villus sampling after the first trimester.Fetal karyotyping by chorionic villus sampling after the first trimester.
What is chorionic villus sampling?What is chorionic villus sampling?
Handbook of Genetic Counseling/Chorionic Villus Sampling (CVS) - Wikibooks, open books for an open worldHandbook of Genetic Counseling/Chorionic Villus Sampling (CVS) - Wikibooks, open books for an open world
Chorionic Villus Sampling (CVS) - AHealthyMe - Blue Cross Blue Shield of MassachusettsChorionic Villus Sampling (CVS) - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Chorionic Villus Sampling-Transcervical - Lahey HealthChorionic Villus Sampling-Transcervical - Lahey Health
Prenatal Test: Chorionic Villus Sampling (CVS)Prenatal Test: Chorionic Villus Sampling (CVS)
Chorionic villus sampling (CVS) | Cone HealthChorionic villus sampling (CVS) | Cone Health
Amniocentesis and chorionic villus sampling for prenatal diagnosis | RHLAmniocentesis and chorionic villus sampling for prenatal diagnosis | RHL
CMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus SamplingCMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling
Pregnancy Exams - Ultrasounds, Amniocentesis Tests, & Chorionic Villus SamplingPregnancy Exams - Ultrasounds, Amniocentesis Tests, & Chorionic Villus Sampling
Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study - Tabor - 2009 -...Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study - Tabor - 2009 -...
NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)NewYork-Presbyterian Queens - Chorionic Villus Sampling (CVS)
AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Chorionic VilliChorionic Villi SamplingPrenatal DiagnosisAmniocentesisPregnancy Trimester, FirstPregnancyTrophoblastsPlacentaFetal DiseasesChromosome DisordersFetomaternal TransfusionKaryotypingPregnancy, TubalGestational AgeUltrasonography, PrenatalAbortion, SpontaneousMethemalbuminChorionTrisomyAmniotic FluidPlacentationDown SyndromeCordocentesisPregnancy, High-RiskMaternal AgeMosaicismAmnionAneuploidyHydatidiform MoleNeckAbortion, EugenicChromosome AberrationsDeciduaAbortion, SepticCrown-Rump LengthPregnancy Reduction, MultifetalPregnancy Trimester, SecondFetusNuchal Translucency MeasurementPregnancy, MultipleIntestine, SmallPre-EclampsiaPregnancy Trimester, ThirdJejunumGenetic CounselingIntestinal Mucosabeta-ThalassemiaAbortion, InducedPregnancy OutcomeChoriocarcinomaLeukemia Inhibitory Factor Receptor alpha SubunitMicrovilliHeterozygote DetectionChromosomes, Human, Pair 18IleumFetal DeathAbnormalities, MultipleBasement MembraneImmunohistochemistryFluorescent Antibody Technique
AmnioticCasesPlacentaAmniotic FluidGeneticProcedurePlacentalBiopsyChorionPregnancyAmniocentesis and Chorionic villus SFetusTransabdominal or transcervicalChromosomeIsolated from first-trimesterTrimesterMiscarriageAdvantage of chorionicUterusCell-free fetalMethod of prenatal diagnosisRisksAmniocytesCervixChromosomal disorderBaby'sNuchal translucencySampling DoneSamples10thSpecimen
Amniotic1
Cases1
Placenta34
Amniotic Fluid5
Genetic26
Procedure11
Placental7
Biopsy7
Chorion8
Pregnancy18
Amniocentesis and Chorionic villus S5
Fetus3
  • A sample of the pregnant woman's blood is analyzed for three substances produced by the fetus and passed into the mother's blood: alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), and unconjugated estriol (UE3). (encyclopedia.com)
  • Chorionic villus sampling (CVS) is a test that can find certain problems with your fetus . (nkch.org)
  • By checking a sample of chorionic villi, the laboratory can see whether or not the chromosomes are normal in number and structure, determine the fetal sex, and test for some specific diseases (if the fetus may be at risk for these diseases). (dummies.com)
Transabdominal or transcervical1
Chromosome3
Isolated from first-trimester1
Trimester4
Miscarriage3
Advantage of chorionic1
Uterus1
  • Once the catheter or needle reaches the chorionic villi, your surgeon withdraws a small sample and carefully removes it from the uterus. (medlineplus.gov)
Cell-free fetal3
Method of prenatal diagnosis1
  • In 1983, an Italian biologist named Giuseppe Simoni discovered a new method of prenatal diagnosis using chorionic villi. (wikipedia.org)
Risks4
Amniocytes2
Cervix1
Chromosomal disorder1
Baby's2
Nuchal translucency1
Sampling Done2
Samples3
10th1
Specimen1
Amniotic Fluid & Chorionic Villus Cells<...
Amniotic Fluid & Chorionic Villus Cells<... (bioind.com)
Pregnancy | Britannica.com
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A Perinatology Glossary : ULTRASOUND - latimes
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Chorionic Villus Sampling | Encyclopedia.com
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Bioethics - The Interim
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Health Topics: C: MedlinePlus
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January 1997 - Volume 16 - Issue 1 : International Journal of Gynecological Pathology
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Animal Cell Culture / Edition 1 by Jeffrey W. Pollard | 9780896031500 | Hardcover | Barnes & Noble®
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Early Development Of Human Trophoblast
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Gestational and Placental Disorders Flashcards by 🌈 Languages | Brainscape
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Free Anatomy Flashcards about reproductive/develop
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Karyotype Genetic Test: MedlinePlus Medical Test
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Cytogenetics Specimen Requirements, Mailing Instructions and Forms
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Cytogenetics of Chorionic Villi Sampling: Technical Developments and Diagnostic Applications | Springer for Research &...
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Transcriptional consequences of aneuploidy | PNAS
Transcriptional consequences of aneuploidy | PNAS (pnas.org)
Placenta and Extraembryonic Membranes
Placenta and Extraembryonic Membranes (med.umich.edu)
Chorionic villus sampling: MedlinePlus Medical Encyclopedia Image
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Prenatal Testing | Gestational Diabetes | MedlinePlus
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Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a...
Development of Some Organs Derived from the Three Embryonic Germ Layer in a Degus Ectopic Pregnancy and Presence of a... (hindawi.com)
Connection | Harvard Catalyst Profiles | Harvard Catalyst
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Interim Guidelines for the Evaluation of Infants Born to Mothers Infected with West Nile Virus During Pregnancy
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Interactive Prenatal Development Timeline - Intermediate
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Prenatal Diagnosis of Disorders of Carbohydrate Metabolism | SpringerLink
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Genetic testing - Wikipedia
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Chorionic Villi Sampling (CVS) - Women's Health and Halacha - Nishmat
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PPT - Suspected Ectopic Pregnancy PowerPoint Presentation - ID:53849
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Moms Who Think - Pregnancy Terms Glossary
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Prenatal development | physiology | Britannica.com
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Protein kinase profiling in miscarriage: implications for the pathogenesis of trisomic pregnancy. | CureHunter
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Screening for Pregnancy Risks Over Age 35
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Chorionic Villus Sampling-Transcervical - Lahey Health
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