The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.
Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.
Those protein complexes or molecular sites on the surfaces of gonadal and other sensitive cells that bind gonadotropins and thereby modify the functions of those cells; hCG, LH, and FOLLICLE STIMULATING HORMONE are the major specific gonadotropins.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).

The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. (1/497)

OBJECTIVE: To assess the effectiveness of non-surgical management of interstitial pregnancy. DESIGN: A prospective interventional study. SUBJECTS: Eleven women with the ultrasound diagnosis of interstitial ectopic pregnancy. METHODS: Women with suspected early pregnancy complications were examined by transvaginal ultrasound. Those with the diagnosis of interstitial pregnancy were offered non-surgical treatment with methotrexate, which was administered systemically or by local injection. Follow-up with regular measurements of beta-human chorionic gonadotropin and ultrasound scans continued until the pregnancy had resolved completely. RESULTS: Ten women were managed non-surgically, and one woman opted for surgery. Five women received systemic and five local methotrexate. Local therapy was successful in all five cases (100%), whereas four out of five (80%) women receiving systemic methotrexate were cured. Significant side-effects were noted in two women following systemic therapy. In comparison, there were no side-effects in the group of women who received local therapy. There were no significant differences between the two treatment groups in the length of time taken for the pregnancy to resolve. CONCLUSIONS: Non-surgical treatment of interstitial pregnancy with methotrexate appears to be safe and effective. Local administration appears to be more successful and better tolerated by patients and may be used as the first-line therapy.  (+info)

Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience. Societe Francaise d'Oncologie Pediatrique. (2/497)

Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Societe Francaise d'Oncologie Pediatrique initiated a study combining chemotherapy (alternating courses of etoposide-carboplatin and etoposide-ifosfamide for a recommended total of four courses) with 40 Gy local irradiation for patients with localized germinomas. Metastatic patients were allocated to receive low-dose craniospinal radiotherapy. Fifty-seven patients were enrolled between 1990 and 1996. Forty-seven had biopsy-proven germinoma. Biopsy was not performed in ten patients (four had diagnostic tumour markers and in six the neurosurgeon felt biopsy was contraindicated). Fifty-one patients had localized disease, and six leptomeningeal dissemination. Seven patients had bifocal tumour. All but one patient received at least four courses of chemotherapy. Toxicity was mainly haematological. Patients with diabetus insipidus (n = 25) commonly developed electrolyte disturbances during chemotherapy. No patient developed tumour progression during chemotherapy. Fifty patients received local radiotherapy with a median dose of 40 Gy to the initial tumour volume. Six metastatic patients, and one patient with localized disease who stopped chemotherapy due to severe toxicity, received craniospinal radiotherapy. The median follow-up for the group was 42 months. Four patients relapsed 9, 10, 38 and 57 months after diagnosis. Three achieved second complete remission following salvage treatment with chemotherapy alone or chemo-radiotherapy. The estimated 3-year survival probability is 98% (CI: 86.6-99.7%) and the estimated 3-year event-free survival is 96.4% (CI: 86.2-99.1%). This study shows that excellent survival rates can be achieved by combining chemotherapy and local radiotherapy in patients with non-metastatic intracranial germinomas.  (+info)

Hyperreactio luteinalis associated with chronic renal failure. (3/497)

Hyperreactio luteinalis is a rare benign condition characterized by bilateral ovarian enlargement associated with pregnancies where high concentrations of maternal serum human chorionic gonadotrophins are present. This condition may mimic the ovarian hyperstimulation syndrome. We report a case of a 34 year old woman with a history of chronic renal failure on haemodialysis who presented at 10 weeks' gestational age with hyperreactio luteinalis which was treated conservatively. Because of chronic renal failure, the presentation and course of the disease was different from that which has been previously reported.  (+info)

Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta. (4/497)

The primary objective of this study was to characterize an in-vitro model of the human placenta using morphological, biochemical and physiological parameters. Placental villi were obtained from normal first trimester and term pregnancies. The villi were incubated with Dulbecco's modified Eagle's medium: Ham's F12 nutrient mixture in a shaking water bath at 37 degrees C for up to 310 min. The viability was determined by the production of beta human chorionic gonadotrophin (HCG) and lactic dehydrogenase (LDH) and the incorporation of [3H]thymidine, [3H]L-leucine and L-[U14C]arginine, while ultrastructure was assessed by transmission electron microscopy. In the first and third trimester group, the release into the medium of the intracellular enzyme LDH remained unaltered throughout the experiment. By contrast, beta-HCG concentrations increased linearly and concentrations were higher in the first trimester than term villi (354.5 +/- 37.8 versus 107 +/- 8.1 IU/g villi protein; P < 0.001). Electron microscopy confirmed preservation of tissue viability for up to 4 h of incubation. The incorporation of thymidine (12.2 +/- 2.9 versus 5.2 +/- 0.5 nmol/g villi protein; P < 0.05), leucine (9.4 +/- 2.1 versus 1.9 +/- 0.4 nmol/g villi protein; P < 0.02) and arginine (17 +/- 4.4 versus 4.2 +/- 0.5 nmol/g villi protein; P < 0.05) were markedly higher in early than in term placenta. Furthermore, placental uptake of L-leucine by the first (9.4 +/- 2.1 versus 17 + 4.4 mol/g villi protein; P < 0.001) and third trimester placental villi (1.9 +/- 0.4 versus 4.2 + 0.5 mol/g villi protein; P < 0.001) was less than that of L-arginine. This study describes a simple technique using placental explants to determine relative rates of uptake of substrate amino acids throughout gestation.  (+info)

Cross-reaction with luteinizing hormone beta-core is responsible for the age-dependent increase of immunoreactive beta-core fragment of human chorionic gonadotropin in women with nonmalignant conditions. (5/497)

BACKGROUND: The beta-core fragment of human chorionic gonadotropin (hCGbetacf), also termed "beta-core" and urinary gonadotropin peptide (UGP), has been reported to be present in the urine of healthy women and to increase in concentration after menopause. This could reflect cross-reaction with the equivalent metabolite of luteinizing hormone (LH), the beta-LH-core. METHODS: We measured immunoreactive LH, hCG, free alpha-subunit, and free beta-subunit hCG (hCGbeta), as well as beta-core, using the S504 RIA and Triton UGP enzyme immunoassay in 274 urine samples from women with nonmalignant gynecological conditions. The molar cross-reaction of each assay with purified beta-LH-core was determined. RESULTS: Cross-reaction with beta-LH-core was 100% in the LH and the S504 beta-core assay, 5% in the Triton UGP assay, and <0.1% in the hCG, free alpha-subunit, and free hCGbeta assays. Median urine concentrations of all analytes showed an age-dependent increase. LH and free alpha-subunit concentrations were approximately 10(3) pmol/mol creatinine; hCG and S504 beta-core were approximately 10(2) pmol/mol creatinine; free hCGbeta and Triton UGP beta-core were in the tens of pmol/mol creatinine. The S504 beta-core concentrations were 10% of those of LH. S504 beta-core was strongly correlated with LH, but not with hCG or with free hCGbeta (LH, r2 = 0.45; hCG, r2 = 0.26; free hCGbeta, r2 = 0.03). The concentrations of beta-core detected by the Triton UGP assay, which has a 5% cross-reaction with beta-LH-core, were 2% of LH and 5% of the S504 beta-core concentrations. Triton UGP values correlated strongly with LH concentrations, but less well with S504 beta-core, intact hCG, and free hCGbeta (LH, r2 = 0.44; S504 beta-core, r2 = 0.33; hCG, r2 = 0.32; free hCGbeta, r2 = 0.19). CONCLUSIONS: Immunoreactive beta-core in women free of malignancies reflects cross-reaction with concentrations of the metabolite of LH, beta-LH-core, within the health-related reference interval.  (+info)

Perinatal outcome in pregnancies with a positive serum screening for Down's syndrome due to elevated levels of free beta-human chorionic gonadotropin. (6/497)

OBJECTIVE: To evaluate the potential clinical use of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and uterine artery Doppler investigation to screen for placenta-related adverse outcome in pregnancies at positive risk for Down's syndrome at 15-18 weeks. DESIGN: A cohort of 329 consecutive pregnant women with a singleton viable pregnancy and a positive risk for Down's syndrome was retrospectively investigated. This group was obtained from an unselected population of 3952 women attending the same hospital over a 2-year period. Using the results of this first analysis, we selected a group of 26 women with unexplained high levels of free beta-hCG and followed them prospectively with monthly ultrasound and uterine artery Doppler examinations. RESULTS: In the retrospective cohort, risk ratios stratified for maternal serum beta-hCG multiple of the median (MoM) values indicated that the highest incidence of adverse pregnancy outcome was in those women with values of > or = 5.0. In the prospective study, pregnancy outcome was complicated by uteroplacental disorders in eight cases. Analysis of the Doppler investigation indicated that, in women with a very high level of hCG, an abnormally high uterine artery pulsatility index (PI) had lower sensitivity and negative predictive value than early diastolic notch, whereas the specificity and positive predictive value were higher for a high uterine artery PI. CONCLUSIONS: These findings suggest an association between a high level of maternal serum beta-hCG at 15-18 weeks, the presence of an early diastolic notch in the uterine artery flow velocity waveform and adverse pregnancy outcome due to abnormal development of the uteroplacental circulation. Young women with an unexplained high beta-hCG level would benefit, apart from detailed sonography of the fetus and/or karyotyping, from uterine Doppler investigation and counselling about the follow-up and management of placenta-related pregnancy disorders.  (+info)

Arteriovenous malformation of mesosalpinx associated with a 'vanishing' ectopic pregnancy: diagnosis with three-dimensional color power angiography. (7/497)

We describe two cases of pelvic arteriovenous malformation diagnosed with the aid of three-dimensional color power angiography. In both cases, beta-human chorionic gonadotropin (beta-hCG) increased to significant levels (8413 and 1560 mIU/ml, respectively); however, neither an intrauterine nor an adnexal gestational sac could be found. In each case, we observed an adnexal mass with several tortuous areas exhibiting abundant turbulent flow. The diagnosis of arteriovenous malformation was made and further assessment by three-dimensional color power angiography and magnetic resonance imaging (MRI) was carried out. The complex vascular anatomy of arteriovenous malformation, including its feeding vessels and drainage, was clearly depicted by three-dimensional color power angiography and correlated well with magnetic resonance angiography. Levels of beta-hCG decreased in subsequent tests, and eventually became negative 2-3 months later without and intervention. We believe that an involutional ectopic pregnancy induced the rapid growth of the arteriovenous malformations within the mesosalpinx. Three-dimensional color power angiography can be performed quickly and easily, using existing ultrasound equipment. It improves our understanding of complicated vasculature, and thus is a useful adjunct to two-dimensional and color Doppler ultrasound in the diagnosis of arteriovenous malformation.  (+info)

Cervical pregnancy--a conservative stepwise approach. (8/497)

A case of cervical pregnancy resistant to intramuscular methotrexate therapy is presented, which was successfully treated by intra-arterial methotrexate followed by selective prophylactic hypogastric artery embolization to avoid aggravating the vaginal bleeding. It is suggested that, in cervical pregnancies in which fertility preservation is desired, a stepwise conservative approach should be applied before resorting to surgical intervention.  (+info)

The symptoms of choriocarcinoma can vary depending on the location and size of the tumor, but they may include:

* Abnormal vaginal bleeding
* Pelvic pain
* Abdominal pain
* Weakness and fatigue
* Shortness of breath
* Nausea and vomiting

If choriocarcinoma is suspected, a variety of tests may be performed to confirm the diagnosis. These may include:

* Ultrasound: This imaging test uses high-frequency sound waves to create pictures of the uterus and ovaries. It can help doctors identify any abnormal growths or tumors in the area.
* Hysteroscopy: This procedure involves inserting a thin, lighted tube through the cervix to visualize the inside of the uterus. Doctors may use hysteroscopy to collect samples of tissue for testing.
* Laparoscopy: This procedure involves making small incisions in the abdomen and using a thin, lighted tube to visualize the inside of the pelvis. Doctors may use laparoscopy to collect samples of tissue for testing or to remove any tumors that are found.
* Biopsy: In this test, doctors take a small sample of tissue from the uterus and examine it under a microscope for cancer cells.

If choriocarcinoma is confirmed, treatment may involve a combination of surgery, chemotherapy, and radiation therapy. The specific treatment plan will depend on the stage and location of the cancer, as well as the patient's overall health.

Prognosis for choriocarcinoma varies depending on the stage of the cancer when it is diagnosed. In general, the prognosis is good if the cancer is caught early and treated promptly. However, if the cancer has spread to other parts of the body (metastasized), the prognosis may be poorer.

It's important for women who have had a molar pregnancy or choriocarcinoma to follow up with their healthcare provider regularly to ensure that any remaining tissue is removed and to monitor for any signs of recurrence.

... chorionic gonadotropin". Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin ... Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ... "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492-9. doi:10.1016/ ...
"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". The Journal of Biological ... Bellisario R, Carlsen RB, Bahl OP (Oct 1973). "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit". ... The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), ... cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin". Nature. 281 (5730): 351-6. ...
"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin ... Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1984). "The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19". Hum. Genet. 67 (2): 174-177 ...
But GTD also leads to elevated serum hCG (human chorionic gonadotropin hormone). Since pregnancy is by far the most common ... the beta subunit of hCG (beta hCG) is also always elevated. Therefore, if GTD is clinically suspected, serum beta hCG is also ... This tissue may grow at the same rate as a normal pregnancy, and produces chorionic gonadotropin, a hormone which is measured ... Walkington L, Webster J, Hancock BW, Everard J, Coleman RE (May 2011). "Hyperthyroidism and human chorionic gonadotrophin ...
Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1994). "Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human ... "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit ... In equids the beta subunit polypeptides of luteinizing hormone and chorionic gonadotropin are identical in sequence, differing ...
"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene ... Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin ... 1985). "Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta". Nucleic ...
Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded ... chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a ... of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. ... "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human ...
... monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene". Molecular Endocrinology. 17 (1): 11-26. ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin ( ... Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ... "No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women". Endocrine. 34 (1-3): 117- ...
... beta-subunit of human chorionic gonadotropin linked to tetanus toxoid". Fertil Steril. 34 (4): 328-35. doi:10.1016/s0015-0282( ... "Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma". Gut. 42 (1): 88-91. doi: ... neuroendocrine tumors exclusively produce human chorionic gonadotropin a-subunit (hCGa)". Hum Pathol. 31 (8): 966-972. doi: ... "A novel human cancer vaccine elicits cellular responses to the tumor-associated antigen, human chorionic gonadotropin b". Clin ...
"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... 1990). "Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer ... Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene ... "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". J. Biol. Chem. 250 (13): 5247-58 ...
... and human chorionic gonadotropin (hCG). The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist ... while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids ( ... "Gonadotropin-releasing hormone regulation of gonadotropin subunit gene expression in female rats: actions on follicle- ... In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3. It is expressed in two cell types, most ...
... and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits (labeled alpha- and beta- subunits ... "Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone and human follicle-stimulating hormone on ... This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both ... The beta subunits vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is ...
"Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary". J. Clin. ... beta) subunit that is unique to hCG. The α (alpha) subunit is 92 amino acids long. The β-subunit of hCG gonadotropin (beta-hCG ... "Fusing the carboxy-terminal peptide of the chorionic gonadotropin (CG) beta-subunit to the common alpha-subunit: retention of O ... Beta-hCG is initially secreted by the syncytiotrophoblast.[citation needed] Human chorionic gonadotropin is a glycoprotein ...
... look for the presence of the beta subunit of human chorionic gonadotropin (hCG) in blood or urine. For a qualitative test the ... Lenton, E. A.; Neal, L. M.; Sulaiman, R. (June 1982). "Plasma concentrations of human chorionic gonadotropin from the time of ... The two primary methods are testing for the female pregnancy hormone (human chorionic gonadotropin (hCG)) in blood or urine ... Identified in the early 20th century, human chorionic gonadotropin (hCG) is a glycoprotein hormone that rises quickly in the ...
"Human Chorionic Gonadotropin (hCG) in the Secretome of Cultured Embryos: Hyperglycosylated hCG and hCG-Free Beta Subunit Are ... Cole, Laurence A.; Butler, Stephen A. (17 February 2020). 100 Years of Human Chorionic Gonadotropin: Reviews and New ...
... the alpha and the beta subunit. The α (alpha) subunit (i.e., chorionic gonadotropin alpha) is nearly identical to that of human ... The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The β chain has a 118-amino ... chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The α subunit is thought to be ... receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse ...
... chorionic gonadotropin MeSH D06.472.699.649.367.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.699.649.367.562 ... chorionic gonadotropin MeSH D06.472.351.326.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.351.326.562 - ... chorionic gonadotropin MeSH D06.472.759.367.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.759.367.562 - ... beta subunit MeSH D06.472.699.631.525.343.288.625 - follicle stimulating hormone, human MeSH D06.472.699.631.525.343.288.750 - ...
... chorionic gonadotropin, beta subunit, human MeSH D23.101.840.375 - hormones, ectopic MeSH D23.101.840.400 - ki-67 antigen MeSH ... human platelet MeSH D23.050.705.230 - blood group antigens MeSH D23.050.705.230.031 - abo blood-group system MeSH D23.050. ... transforming growth factor beta MeSH D23.348.479.996 - wnt proteins MeSH D23.348.479.996.500 - wnt1 protein MeSH D23.348. ... beta carotene MeSH D23.767.261.700 - retinoids MeSH D23.767.261.700.050 - acitretin MeSH D23.767.261.700.250 - etretinate MeSH ...
GCCL have been long known for secretion of the beta subunit of human chorionic gonadotropin (beta-HCG), often in large amounts ... Yaturu S, Harrara E, Nopajaroonsri C, Singal R, Gill S (2003). "Gynecomastia attributable to a human chorionic gonadotropin- ... Dailey JE, Marcuse PM (August 1969). "Gonadotropin secreting giant cell carcinoma of the lung". Cancer. 24 (2): 388-96. doi: ... "A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer ...
... chorionic gonadotropin MeSH D12.644.548.726.367.125 - chorionic gonadotropin, beta subunit, human MeSH D12.644.548.726.367.562 ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 - gtp-binding protein gamma subunits MeSH D12.644.360.375.940 - ... beta subunit MeSH D12.644.548.691.525.343.288.750 - glycoprotein hormones, alpha subunit MeSH D12.644.548.691.525.343.463 - ... alpha subunit MeSH D12.644.548.691.525.883.500 - thyrotropin, beta subunit MeSH D12.644.548.691.692 - pituitary hormones, ...
... and hence that synthesis of alpha and beta is independently regulated. Another human gonadotropin is human chorionic ... These subunits are heavily modified by glycosylation. The alpha subunit is common to each protein dimer (well conserved within ... the placental/chorionic gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), as well as ... Laurence A. Cole (21 September 2010). Human Chorionic Gonadotropin (hCG). Elsevier. pp. 205-. ISBN 978-0-12-384908-3. Basaria S ...
Testicular effects of isolated luteinizing hormone deficiency and reversal by long-term human chorionic gonadotropin treatment ... Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone N Engl J Med. 1992; 326(3): ... Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. N Engl J Med. 2004; 351(25):2619-25. ... full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total ...
"Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement ... Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB (July 2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a ... "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin ... "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of ...
Follicle-stimulating hormone Human chorionic gonadotropin Bonnet macaque Folliculogenesis India portal Medicine portal His ... "Passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion-a ... He was a member of the task force of the World Health Organization for research in human reproduction for a number of years, ... He was known for his pioneering researches on gonadotropin and was an elected fellow of the Indian Academy of Sciences and the ...
"The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and ... gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include presenilin ... "Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic ... The pregnancy hormone human chorionic gonadotropin (hCG) increases AβPP expression and hESC proliferation while progesterone ...
... chorionic gonadotropin - chromatid - chromatin - ciclosporin - chromatography - chromosomal crossover - chromosome - chromosome ... beta-2 microglobulin - beta adrenergic receptor - beta sheet - beta-1 adrenergic receptor - beta-2 adrenergic receptor - beta- ... protein subunit - protein synthesis - protein targeting - protein translocation - protein-tyrosine kinase - protein-tyrosine- ... Human Genome Project - hybridization - hydrocarbon - hydrogen - hydrogen bond - hydrogenation - hydrogen-deuterium exchange - ...
Disappearance of human chorionic gonadotropin and its alpha- and beta-subunits after term pregnancy. Clin Chem 1997;43:2155-63 ... Human chorionic gonadotropin in maternal plasma after induced abortion, spontaneous abortion, and removed ectopic pregnancy. ... Human chorionic gonadotropin tests. Expert Rev Mol Diagn 2009;9:721-47. http://dx. doi. org/10. 1586/erm. 09. 51 PubMed ... Reyes FI, Winter JS, Faiman C. Postpartum disappearance of chorionic gonadotropin from the maternal and neonatal circulations. ...
Early termination combined with vaginal ultrasonography and follow-up with beta-human chorionic gonadotropin measurements ... Chorionic Gonadotropin, beta Subunit, Human / blood Actions. * Search in PubMed * Search in MeSH ... Change in serum beta-human chorionic gonadotropin after abortion with methotrexate and misoprostol. Creinin MD. Creinin MD. Am ... Early termination combined with vaginal ultrasonography and follow-up with beta-human chorionic gonadotropin measurements ...
... as well as to the alpha subunit of human thyroid-stimulating hormone (TSH). The beta subunits of these hormones differ in amino ... Chorionic gonadotropin is a purified preparation composed of an alpha and a beta subunit. The alpha subunit is essentially ... chorionic gonadotropin) for injection. DESCRIPTION. Chorionic gonadotropin, a gonadotropin, is a polypeptide hormone produced ... Human chorionic gonadotropins can crossreact in the radioimmunoassay of gonadotropins, especially luteinizing hormone. Each ...
MeSH Terms: Biomarkers/blood; Chorionic Gonadotropin, beta Subunit, Human/blood; Diabetes, Gestational/blood*; Female; Humans; ... and/or free β-human chorionic gonadotropin (free β-hCG) levels with GDM diagnosis. Mean differences were calculated comparing ... NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human ... is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health ...
5. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.. Morgan FJ; Birken S; Canfield ... Molecular Biopsy of Human Tumors. - a resource for Precision Medicine *. 208 related articles for article (PubMed ID: 35469201) ... 6. Amino acid sequence of human tumor derived angiogenin.. Strydom DJ; Fett JW; Lobb RR; Alderman EM; Bethune JL; Riordan JF; ... Primary and tertiary structure of the principal human adenylate kinase.. Von Zabern I; Wittmann-Liebold B; Untucht-Grau R; ...
Judith Vaitukaitis was inducted into the NICHD Hall of Honor "for discovery of the beta subunit of human chorionic gonadotropin ... Human Chorionic Gonadotropin (hCG) was a fascinating hormone to study in 1970, partly because not much was known about its ... JV: We were looking at structure-function studies of human chorionic gonadotropin. Was there biologic activity in the isolated ... JV: Canfields laboratory was isolating the human chorionic gonadotropin from the pregnancy urine, and he had isolated it and ...
... and human chorionic gonadotropin (hCG). The unique beta subunit determines LH immunologic and biologic activity. The half-life ... The alpha subunit is composed of 92 amino acids and is encoded on the long arm of chromosome 6. The beta subunit is 121 amino ... Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. N Engl J Med. 2004 Dec 16. 351(25):2619 ... LH and hCG act via the luteinizing hormone chorionic gonadotropin receptor (LHCGR). This transmembrane G protein-coupled ...
Alpha-fetoprotein (AFP) and beta subunit human chorionic gonadotropin (beta-HCG) levels in both serum and CSF, and cytology, if ... and beta subunit human chorionic gonadotropin [beta-HCG]) and for cytopathological review. Ventricular tumor markers are ... Beta-HCG. AFP. PLAP. c-kit. AFP = alpha-fetoprotein; HCG = human chorionic gonadotropin; PLAP = placental alkaline phosphatase ... Fujimaki T, Mishima K, Asai A, et al.: Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with ...
Human Chorionic Gonadotropin, beta Polypeptide, Human HCG, beta Subunit HCG-beta Human Chorionic Gonadotropin, beta Subunit ... Gonadotropins [D06.472.699.322] * Chorionic Gonadotropin [D06.472.699.322.326] * Chorionic Gonadotropin, beta Subunit, Human [ ... CHORIONIC GONADOTROPIN BETA SUBUNIT HUMAN. Entry Term(s). Chorionic Gonadotropin, beta Chain, ... Chorionic Gonadotropin, beta Subunit, Human Preferred Concept UI. M0028371. Registry Number. 0. Scope Note. The beta subunit of ...
NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children ... She identifies the beta subunit of human chorionic gonadotropin as the earliest marker of pregnancy, which leads to the ... Human growth and development are life-long processes that have many phases and functions. Much of the institutes research in ... She is a former member of the Board of Directors of the American Society for Human Genetics and a former council member of both ...
... human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH, thyrotropin), consists of two noncovalently associated ... The alpha subunit of FSH contains 92 amino acids and is very similar to the alpha subunits of LH, hCG, and TSH. The beta ... Human follicle stimulating hormone (FSH, follitropin) is a glycoprotein of approximately 30,000 daltons which, like luteinizing ... The LH binds to the Anti-beta FSH Coated Microparticles forming an antibody-antigen complex. An aliquot of the reaction mixture ...
Research conducted and funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ... NICHD investigators identified the beta subunit of human chorionic gonadotropin (hCG) as the earliest marker of pregnancy, ... Transforming the Study of Human Fertility By identifying luteinizing hormone releasing factor (LHRF, now called gonadotropin- ... US Department of Health and Human Services National Institutes of Health Directory Follow follow us on Facebook follow us on ...
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits ... The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are ... HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and ... alpha and beta which are non-covalently associated. ... U.S. Department of Health and Human Services. *National ...
... of pregnant women and is correlated to the level of human chorionic gonadotropin (hCG). Hyperemesis gravidarum (HG) is a severe ... Goodwin TM, Hershman JM, Cole L. Increased concentration of the free beta-subunit of human chorionic gonadotropin in ... HG hyperemesis gravidarum, hCG human chorionic gonadotropin, IU international unit. *Originaly in IU/ml ... of pregnant women and is correlated to the level of human chorionic gonadotropin (hCG). Hyperemesis gravidarum (HG) is a severe ...
... of ovine luteinizing hormone by carrier conjugation and combination with the beta-subunit of human chorionic gonadotropin. ... Enhancement of antigonadotropin response to the beta-subunit ... Department of Health and Human Services (HHS). Unauthorized use ...
Chorionic Gonadotropin, beta Subunit, Human D23.101.840.325 D23.101.140.325 Chorionic Villi Sampling E1.370.225.500.384.150 ... beta-Defensins D12.644.276.87.54 D12.776.467.87.188 D23.529.87.233 beta-Endorphin D12.644.468.241.80 beta-Lactam Resistance ... Human B4.909.777.500.540.150.210 Coronavirus NL63, Human B4.909.777.500.540.150.215 Coronavirus OC43, Human B4.909.777.500. ... Human B4.909.777.618.284.180 Enterovirus B, Human B4.909.777.618.284.182 Enterovirus C, Human B4.909.777.618.284.184 ...
Chorionic Gonadotropin, beta Polypeptide, Human HCG beta HCG, beta Subunit HCG-beta Human Chorionic Gonadotropin, beta Subunit ... Chorionic Gonadotropin, beta Polypeptide, Human. HCG beta. HCG, beta Subunit. HCG-beta. Human Chorionic Gonadotropin, beta ... Chorionic Gonadotropin, beta Subunit, Human - Preferred Concept UI. M0028371. Scope note. The beta subunit of human CHORIONIC ... Chorionic Gonadotropin, beta Subunit, Human Entry term(s). Chorionic Gonadotropin, beta Chain, Human ...
Human Chorionic Gonadotropin, beta Polypeptide, Human HCG, beta Subunit HCG-beta Human Chorionic Gonadotropin, beta Subunit ... Gonadotropins [D06.472.699.322] * Chorionic Gonadotropin [D06.472.699.322.326] * Chorionic Gonadotropin, beta Subunit, Human [ ... CHORIONIC GONADOTROPIN BETA SUBUNIT HUMAN. Entry Term(s). Chorionic Gonadotropin, beta Chain, ... Chorionic Gonadotropin, beta Subunit, Human Preferred Concept UI. M0028371. Registry Number. 0. Scope Note. The beta subunit of ...
Prolactin (PRL), human placental lactogen (hPL), the beta-subunit of human chorionic gonadotropin (betahCG), testosterone (T), ... delta 5-Androstene-3 beta,17 beta-diol in healthy eumenorrheic women: relationship to body mass and hormonal profile. Azziz, R ... Changing 17 beta-hydroxysteroid dehydrogenase activity in preimplantation rat and mouse embryos. Wu, J.T., Matsumoto, P.S. Biol ... Transport of equine estrogens: binding of conjugated and unconjugated equine estrogens with human serum proteins. Pan, C.C., ...
... human chorionic gonadotropin hormone and its free beta subunit) in human serum. The B·R·A·H·M·S hCG+β KRYPTOR test is indicated ...
He had hematuria and the human chorionic gonadotropin beta subunit level was slightly elevated. T2-weighedmagnetic resonance ... Beta-human chorionic gonadotropin, alpha-fetoprotein, and lactate dehydrogenase were normal. Scrotal ultrasonography revealed ... Serum human chorionic gonadotropin (3.90 mIU/ml) was raised and alpha-fetoprotein (3.79 ng/ml) was within normal limits. ...
Chorionic Gonadotropin, beta Subunit, Human. 7. + 25. Dacarbazine. 7. + 26. Excitatory Amino Acid Transporter 1. 6. + ...
Keywords: Pregnancy, Abdominal; Douglas Pouch; Hemoperitoneum; Chorionic Gonadotropin, beta Subunit, Human; Ultrasound Imaging ... She had a beta human chorionic gonadotropin level of 14 444 mIU/mL. Diagnostic laparoscopy revealed a hemoperitoneum, bulky ...
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ... The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are ... CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers ... The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and ...
... beta Subunit, Human N0000168121 Chorismate Mutase N0000166668 Chorismic Acid N0000007918 Chromans N0000007919 Chromates ... and Chondroitin Lyases N0000167602 Chondroitinsulfatases N0000006057 Chorionic Gonadotropin N0000171362 Chorionic Gonadotropin ... Interleukin-12 Receptor beta 1 Subunit N0000175289 Interleukin-12 Receptor beta 2 Subunit N0000175309 Interleukin-12 Subunit ... beta 2-Glycoprotein I N0000169400 beta 2-Microglobulin N0000007226 beta Carotene N0000169947 beta Catenin N0000169677 beta ...
... consisting of a heterospecies human papillomavirus vaccine overdose of the beta subunit of human chorionic gonadotropin hCG ... This study presents evidence of the feasibility of a vaccine human papillomavirus vaccine overdose control of human fertility. ... E mai greu acum, pen-tru ca ne-am human papillomavirus vaccine overdose cu comod-i-tatea, cu tele-vi-zorul si cu toate mof- ... Daca mama va lasa copilul sa fie vac-ci-nat, este human papillomavirus vaccine overdose si cum l-ar da la moarte. Am spus de ...
The beta sub-units of these hormones differ in amino acid sequence. Chorionic gonadotropin is obtained from the human pregnancy ... Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta ... The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone ( ... It is not known whether chorionic gonadotropin is excreted in human milk. Because many drugs are excreted in human milk, ...
Structural analysis of N-linked oligosaccharides of equine chorionic gonadotropin and lutropin beta-subunits  Matsui, Taei; ... LH alpha-subunits were reduced and reoxidized using conditions known to be effective for bovine and human alpha-subunits. The ... Equine chorionic gonadotropin (eCG) and lutropin (eLH) are composed of a- and P-subunits with an identical amino acid sequence ... Reduction and reoxidation of equine gonadotropin alpha-subunits  Bousfield, George R.; Ward, Darrell N. (The Endocrine Society ...
C13.703.720.949.416.218 Chorionic Gonadotropin, beta Subunit, Human D6.472.699.649.367.125 D12.644.548.726.367.125 ... Chorionic D6.472.699.649.367 D12.644.548.726.367 (Replaced for 2003 by Chorionic Gonadotropin) Gonadotropins, Equine D6.472. ... L1.470 Inhibin-beta Subunits D6.472.699.09.500 D6.472.699.337.500 D12.644.548.09.500 D12.644.548.387.500 Inhibins D6.472. ... Human, 21-22 and Y A11.284.187.480.505 A11.284.187.520.300.505 G14.162.520.300.505 Chromosomes, Human, 4-5 A11.284.187.480.280 ...
  • The unique beta subunit determines LH immunologic and biologic activity. (medscape.com)
  • Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. (nih.gov)
  • The beta subunits of these hormones differ in amino acid sequence. (nih.gov)
  • The alpha subunit of LH is biologically identical to 3 other hormones: FSH, thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). (medscape.com)
  • The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). (nih.gov)
  • The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. (nih.gov)
  • The alpha sub-unit is essentially identical to the alpha sub- units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH), while the beta sub- units of these hormones differ. (colinfwatson.com)
  • Western blot analysis was used to examine the size heterogeneity of equine inhibin a- and [S-subunits. (wichita.edu)
  • Inhibin , activin i hormon I ne utiču na genetičku aktivnost za proizvodnju beta podjedinice LH. (wikipedia.org)
  • The alpha subunit is essentially identical to the alpha subunits of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha subunit of human thyroid-stimulating hormone (TSH). (nih.gov)
  • The action of human chorionic gonadotropin (hCG) is virtually identical to that of pituitary LH, although hCG appears to have a small degree of FSH activity as well. (nih.gov)
  • Luteinizing hormone (LH) is a peptide produced by the anterior pituitary, along with follicle-stimulating hormone (FSH), in response to gonadotropin-releasing hormone (GnRH) from the hypothalamus. (medscape.com)
  • LH deficiency can also occur due to stress-related hypogonadotropic hypogonadism, LH subunit mutations, congenital pituitary hormone deficiency (CPHD), pituitary tumors, inflammation, vascular accidents, and pregnancy-related hemorrhagic shock (Sheehan syndrome). (medscape.com)
  • Chorionic gonadotropin, a gonadotropin, is a polypeptide hormone produced by the human placenta and obtained from the urine of pregnant persons. (nih.gov)
  • Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta sub-unit. (nih.gov)
  • Each multiple-dose vial is only for use in one patient and contains 10,000 USP units of chorionic gonadotropin with dibasic sodium phosphate (4.4 mg) and monobasic sodium phosphate (5 mg). (nih.gov)
  • Chorionic Gonadotropin for Injection, USP is available in multiple dose vials containing 10,000 USP units with accompanying Bacteriostatic Water for Injection for reconstitution. (nih.gov)
  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). (nih.gov)
  • The best test they had in 1970 was an immunoassay that could measure hCG but could not distinguish between hCG and luteinizing hormone (LH), another of the human gonadotropins that shares its biological characteristics. (nih.gov)
  • LH and hCG act via the luteinizing hormone chorionic gonadotropin receptor (LHCGR). (medscape.com)
  • Its structure is similar to the beta subunit of LUTEINIZING HORMONE , except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. (nih.gov)
  • Abstract We report here results of clinical trials on a birth control vaccine, consisting of a heterospecies human papillomavirus vaccine overdose of the beta subunit of human chorionic gonadotropin hCG associated noncovalently with the alpha subunit of ovine luteinizing hormone and conjugated to tetanus and diphtheria toxoids as carriers, that induces antibodies of high avidity K a approximately 10 10 M-1 against hCG. (malaimare.ro)
  • This preparation of Human Luteinizing Hormone, Beta Subunit ( β -hLH) is isolated from highly purified, intact hLH and is provided as a powder, lyophilized from ammonium bicarbonate. (scrippslabs.com)
  • PREGNYL ® (chorionic gonadotropin) for injection is a sterile, dried powder for intramuscular injection after reconstitution. (nih.gov)
  • Gonal-f ® (follitropin alfa for injection) is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the α- and β-subunits. (rxlist.com)
  • When injected as a vaccine to a non-pregnant woman, this Beta HCG sub unit combined with tetanus toxoid develops antibodies against tetanus and HCG so that if a woman's egg becomes fertilized, her own natural HCG will be destroyed rendering her permanently infertile, the bishops explain. (wordpress.com)
  • Equine chorionic gonadotropin (eCG) and lutropin (eLH) are composed of a- and P-subunits with an identical amino acid sequence but show different biological activities. (wichita.edu)
  • This study indicates that short peptide segments, in addition to full-length AFP, and domain and subdomain fragments of AFP, could be employed as functional agents to help unravel the complexity of biological roles ascribed to human AFP. (atlasgeneticsoncology.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Platelet Derived Growth Factor Subunit B (PDGFB) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (scalegen.com)
  • Description: A competitive ELISA for quantitative measurement of Rat Platelet-derived growth factor subunit B(PDGFB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
  • Description: A competitive ELISA for quantitative measurement of Human Claudin 18(CLDN18) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (resourcerecovery.be)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Claudin 18 (CLDN18) in tissue homogenates, cell lysates and other biological fluids. (resourcerecovery.be)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Claudin 18 (CLDN18) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)
  • The in vivo biological activity of follitropin alfa has been calibrated against the first International Standard for Recombinant Human Follicle Stimulation Hormone established in 1995 by the Expert Committee on Biological Standards of the World Health Organization . (rxlist.com)
  • Use hCG in conjunction with gonadotropin therapy only if the physician is experienced with infertility problems and is familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for gonadotropins. (nih.gov)
  • HCG should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions and adverse reactions described in the package insert for menotropins. (nih.gov)
  • Theα subunit of ovine lutropin can be nicked with the endoproteinase Arg-C to give a single cleavage of the Arg46-Ser47 peptide bond. (wichita.edu)
  • Ovine (o) and equine (e) LH alpha-subunits were reduced and reoxidized using conditions known to be effective for bovine and human alpha-subunits. (wichita.edu)
  • When no chorionic membrane with villi was seen in the curettings, postoperative serum levels of beta-human chorionic gonadotropin confirmed complete evacuation or diagnosed ectopic pregnancy. (nih.gov)
  • The B·R·A·H·M·S hCG+β KRYPTOR test is an automated immunofluorescent assay for the quantitative determination of the concentration of hCG+β (human chorionic gonadotropin hormone and its free beta subunit) in human serum. (brahms.de)
  • Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately treated with human gonadotropins. (nih.gov)
  • Ova beta podjedinica sadrži sekvencu aminokiselina koja pokazuje velike homologije sa beta podjedinicama horionski gonadotropin čovjeka i oba stimuliraju isti receptor. (wikipedia.org)
  • Chorionic gonadotropin is obtained from the human pregnancy urine. (nih.gov)
  • The alpha subunit is composed of 92 amino acids and is encoded on the long arm of chromosome 6. (medscape.com)
  • The beta subunit is 121 amino acids and is encoded on the long arm of chromosome 19. (medscape.com)
  • The α- and β-subunits have 92 and 111 amino acids , respectively, and their primary and tertiary structure are indistinguishable from those of human follicle stimulating hormone. (rxlist.com)
  • 15. Partial amino acid sequence of human plasma retinol-binding protein. (nih.gov)
  • We included original, published, observational studies examining the association of first trimester pregnancy associated plasma protein-A (PAPP-A) and/or free β-human chorionic gonadotropin (free β-hCG) levels with GDM diagnosis. (nih.gov)
  • jedna alfa i jedan beta podjedinica grade puni, funkcijski protein. (wikipedia.org)
  • Description: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. (resourcerecovery.be)
  • 16. The primary structure of human liver manganese superoxide dismutase. (nih.gov)
  • Early termination combined with vaginal ultrasonography and follow-up with beta-human chorionic gonadotropin measurements allows diagnosis of early, unsuspected ectopic pregnancy. (nih.gov)
  • Nausea and vomiting in pregnancy (NVP) affects 50-80% of pregnant women and is correlated to the level of human chorionic gonadotropin (hCG). (biomedcentral.com)
  • LH is a glycoprotein dimer composed of 2 glycosylated noncovalently-linked subunits designated alpha and beta. (medscape.com)
  • hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. (nih.gov)
  • Based on available data derived from physico-chemical tests and bioassays, follitropin alfa and follitropin beta, another recombinant follicle stimulating hormone product, are indistinguishable. (rxlist.com)
  • The bishops' statement notes that in the Philippines, Nicaragua, and Mexico, the tetanus vaccine was "laced with Beta human chorionic gonadotropin (b-HCG) sub unit … to vaccinate women against future pregnancy. (wordpress.com)
  • Scientists did know that the human body secretes hCG only during pregnancy or during certain kinds of cancers. (nih.gov)
  • NICHD investigators identified the beta subunit of human chorionic gonadotropin (hCG) as the earliest marker of pregnancy, leading to the development and subsequent commercialization of the first home pregnancy test. (nih.gov)
  • This study presents evidence of the feasibility of a vaccine human papillomavirus vaccine overdose control of human fertility. (malaimare.ro)
  • Dar daca Dom-nul asa a binevoit ca noi sa suferim aceste vre-muri, apoi tre-buie sa ne supunem si sa human papillomavirus vaccine overdose cu bucurie toate cele ce vin asupra noas-tra, ca din mana lui Dum-nezeu, si nu a vra-j-ma-su-lui. (malaimare.ro)
  • Daca mama va lasa copilul sa fie vac-ci-nat, este human papillomavirus vaccine overdose si cum l-ar da la moarte. (malaimare.ro)
  • 11. Primary and tertiary structure of the principal human adenylate kinase. (nih.gov)
  • Both young doctors arrived in Bethesda in 1970 and in the years they spent with the Reproductive Research Branch-first at the National Cancer Institute (NCI) and then at the National Institute for Child Health and Human Development (NICHD)-they found an active community for the study of reproductive endocrinology. (nih.gov)
  • The mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is to lead research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. (nih.gov)
  • Research conducted and funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has helped save lives, improve wellbeing, and reduce societal costs associated with illness and disability. (nih.gov)
  • Chorionic gonadotropin is a purified preparation composed of an alpha and a beta subunit. (nih.gov)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Su estructura es similar a la de la unidad beta de la LUTROPINA, excepto en los 30 aminoácidos adicionales del extremo carboxi con los residuos de carbohidratos asociados. (bvsalud.org)
  • The major product of oLH alpha refolding was alpha-subunit monomer. (wichita.edu)
  • May 1963 - The Surgeon General appoints members of the National Advisory Child Health and Human Development (NACHHD) Council. (nih.gov)
  • Human Chorionic Gonadotropin (hCG) was a fascinating hormone to study in 1970, partly because not much was known about its behavior or makeup. (nih.gov)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • Human growth and development are life-long processes that have many phases and functions. (nih.gov)
  • Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors. (uchicago.edu)

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