Chorionic Gonadotropin, beta Subunit, Human: The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).Disulfides: Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.Glycoprotein Hormones, alpha Subunit: The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Gonadotropins: Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.Luteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Receptors, LH: Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.Gonadotropins, Equine: Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.Receptors, Gonadotropin: Those protein complexes or molecular sites on the surfaces of gonadal and other sensitive cells that bind gonadotropins and thereby modify the functions of those cells; hCG, LH, and FOLLICLE STIMULATING HORMONE are the major specific gonadotropins.Follicle Stimulating Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.Gonadotropins, Pituitary: Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Hysterectomy: Excision of the uterus.Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)Niobium: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)Ceramics: Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)Transducers: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Equipment Design: Methods of creating machines and devices.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)Seminoma: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)Dysgerminoma: A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Phosphopyruvate Hydratase: A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its own tissue specificity.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Cytosol: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)S100 Calcium Binding Protein beta Subunit: A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.Pregnancy, Tubal: The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.Pregnancy, Ectopic: A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).Salpingostomy: Formation of an artificial opening in a fallopian tube.Salpingectomy: Excision of one or both of the FALLOPIAN TUBES.Abortifacient Agents, Nonsteroidal: Non-steroidal chemical compounds with abortifacient activity.Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)Genital Diseases, Female: Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.Obstetrics: A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.Prostatitis: Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Uromodulin: A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.Ubiquitin-Conjugating Enzymes: A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATING ENZYMES. They transfer ubiquitin to the LYSINE of a substrate protein with the assistance of UBIQUITIN-PROTEIN LIGASES.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Cell Line, Tumor: A cell line derived from cultured tumor cells.Ligases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.

The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. (1/497)

OBJECTIVE: To assess the effectiveness of non-surgical management of interstitial pregnancy. DESIGN: A prospective interventional study. SUBJECTS: Eleven women with the ultrasound diagnosis of interstitial ectopic pregnancy. METHODS: Women with suspected early pregnancy complications were examined by transvaginal ultrasound. Those with the diagnosis of interstitial pregnancy were offered non-surgical treatment with methotrexate, which was administered systemically or by local injection. Follow-up with regular measurements of beta-human chorionic gonadotropin and ultrasound scans continued until the pregnancy had resolved completely. RESULTS: Ten women were managed non-surgically, and one woman opted for surgery. Five women received systemic and five local methotrexate. Local therapy was successful in all five cases (100%), whereas four out of five (80%) women receiving systemic methotrexate were cured. Significant side-effects were noted in two women following systemic therapy. In comparison, there were no side-effects in the group of women who received local therapy. There were no significant differences between the two treatment groups in the length of time taken for the pregnancy to resolve. CONCLUSIONS: Non-surgical treatment of interstitial pregnancy with methotrexate appears to be safe and effective. Local administration appears to be more successful and better tolerated by patients and may be used as the first-line therapy.  (+info)

Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience. Societe Francaise d'Oncologie Pediatrique. (2/497)

Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Societe Francaise d'Oncologie Pediatrique initiated a study combining chemotherapy (alternating courses of etoposide-carboplatin and etoposide-ifosfamide for a recommended total of four courses) with 40 Gy local irradiation for patients with localized germinomas. Metastatic patients were allocated to receive low-dose craniospinal radiotherapy. Fifty-seven patients were enrolled between 1990 and 1996. Forty-seven had biopsy-proven germinoma. Biopsy was not performed in ten patients (four had diagnostic tumour markers and in six the neurosurgeon felt biopsy was contraindicated). Fifty-one patients had localized disease, and six leptomeningeal dissemination. Seven patients had bifocal tumour. All but one patient received at least four courses of chemotherapy. Toxicity was mainly haematological. Patients with diabetus insipidus (n = 25) commonly developed electrolyte disturbances during chemotherapy. No patient developed tumour progression during chemotherapy. Fifty patients received local radiotherapy with a median dose of 40 Gy to the initial tumour volume. Six metastatic patients, and one patient with localized disease who stopped chemotherapy due to severe toxicity, received craniospinal radiotherapy. The median follow-up for the group was 42 months. Four patients relapsed 9, 10, 38 and 57 months after diagnosis. Three achieved second complete remission following salvage treatment with chemotherapy alone or chemo-radiotherapy. The estimated 3-year survival probability is 98% (CI: 86.6-99.7%) and the estimated 3-year event-free survival is 96.4% (CI: 86.2-99.1%). This study shows that excellent survival rates can be achieved by combining chemotherapy and local radiotherapy in patients with non-metastatic intracranial germinomas.  (+info)

Hyperreactio luteinalis associated with chronic renal failure. (3/497)

Hyperreactio luteinalis is a rare benign condition characterized by bilateral ovarian enlargement associated with pregnancies where high concentrations of maternal serum human chorionic gonadotrophins are present. This condition may mimic the ovarian hyperstimulation syndrome. We report a case of a 34 year old woman with a history of chronic renal failure on haemodialysis who presented at 10 weeks' gestational age with hyperreactio luteinalis which was treated conservatively. Because of chronic renal failure, the presentation and course of the disease was different from that which has been previously reported.  (+info)

Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta. (4/497)

The primary objective of this study was to characterize an in-vitro model of the human placenta using morphological, biochemical and physiological parameters. Placental villi were obtained from normal first trimester and term pregnancies. The villi were incubated with Dulbecco's modified Eagle's medium: Ham's F12 nutrient mixture in a shaking water bath at 37 degrees C for up to 310 min. The viability was determined by the production of beta human chorionic gonadotrophin (HCG) and lactic dehydrogenase (LDH) and the incorporation of [3H]thymidine, [3H]L-leucine and L-[U14C]arginine, while ultrastructure was assessed by transmission electron microscopy. In the first and third trimester group, the release into the medium of the intracellular enzyme LDH remained unaltered throughout the experiment. By contrast, beta-HCG concentrations increased linearly and concentrations were higher in the first trimester than term villi (354.5 +/- 37.8 versus 107 +/- 8.1 IU/g villi protein; P < 0.001). Electron microscopy confirmed preservation of tissue viability for up to 4 h of incubation. The incorporation of thymidine (12.2 +/- 2.9 versus 5.2 +/- 0.5 nmol/g villi protein; P < 0.05), leucine (9.4 +/- 2.1 versus 1.9 +/- 0.4 nmol/g villi protein; P < 0.02) and arginine (17 +/- 4.4 versus 4.2 +/- 0.5 nmol/g villi protein; P < 0.05) were markedly higher in early than in term placenta. Furthermore, placental uptake of L-leucine by the first (9.4 +/- 2.1 versus 17 + 4.4 mol/g villi protein; P < 0.001) and third trimester placental villi (1.9 +/- 0.4 versus 4.2 + 0.5 mol/g villi protein; P < 0.001) was less than that of L-arginine. This study describes a simple technique using placental explants to determine relative rates of uptake of substrate amino acids throughout gestation.  (+info)

Cross-reaction with luteinizing hormone beta-core is responsible for the age-dependent increase of immunoreactive beta-core fragment of human chorionic gonadotropin in women with nonmalignant conditions. (5/497)

BACKGROUND: The beta-core fragment of human chorionic gonadotropin (hCGbetacf), also termed "beta-core" and urinary gonadotropin peptide (UGP), has been reported to be present in the urine of healthy women and to increase in concentration after menopause. This could reflect cross-reaction with the equivalent metabolite of luteinizing hormone (LH), the beta-LH-core. METHODS: We measured immunoreactive LH, hCG, free alpha-subunit, and free beta-subunit hCG (hCGbeta), as well as beta-core, using the S504 RIA and Triton UGP enzyme immunoassay in 274 urine samples from women with nonmalignant gynecological conditions. The molar cross-reaction of each assay with purified beta-LH-core was determined. RESULTS: Cross-reaction with beta-LH-core was 100% in the LH and the S504 beta-core assay, 5% in the Triton UGP assay, and <0.1% in the hCG, free alpha-subunit, and free hCGbeta assays. Median urine concentrations of all analytes showed an age-dependent increase. LH and free alpha-subunit concentrations were approximately 10(3) pmol/mol creatinine; hCG and S504 beta-core were approximately 10(2) pmol/mol creatinine; free hCGbeta and Triton UGP beta-core were in the tens of pmol/mol creatinine. The S504 beta-core concentrations were 10% of those of LH. S504 beta-core was strongly correlated with LH, but not with hCG or with free hCGbeta (LH, r2 = 0.45; hCG, r2 = 0.26; free hCGbeta, r2 = 0.03). The concentrations of beta-core detected by the Triton UGP assay, which has a 5% cross-reaction with beta-LH-core, were 2% of LH and 5% of the S504 beta-core concentrations. Triton UGP values correlated strongly with LH concentrations, but less well with S504 beta-core, intact hCG, and free hCGbeta (LH, r2 = 0.44; S504 beta-core, r2 = 0.33; hCG, r2 = 0.32; free hCGbeta, r2 = 0.19). CONCLUSIONS: Immunoreactive beta-core in women free of malignancies reflects cross-reaction with concentrations of the metabolite of LH, beta-LH-core, within the health-related reference interval.  (+info)

Perinatal outcome in pregnancies with a positive serum screening for Down's syndrome due to elevated levels of free beta-human chorionic gonadotropin. (6/497)

OBJECTIVE: To evaluate the potential clinical use of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and uterine artery Doppler investigation to screen for placenta-related adverse outcome in pregnancies at positive risk for Down's syndrome at 15-18 weeks. DESIGN: A cohort of 329 consecutive pregnant women with a singleton viable pregnancy and a positive risk for Down's syndrome was retrospectively investigated. This group was obtained from an unselected population of 3952 women attending the same hospital over a 2-year period. Using the results of this first analysis, we selected a group of 26 women with unexplained high levels of free beta-hCG and followed them prospectively with monthly ultrasound and uterine artery Doppler examinations. RESULTS: In the retrospective cohort, risk ratios stratified for maternal serum beta-hCG multiple of the median (MoM) values indicated that the highest incidence of adverse pregnancy outcome was in those women with values of > or = 5.0. In the prospective study, pregnancy outcome was complicated by uteroplacental disorders in eight cases. Analysis of the Doppler investigation indicated that, in women with a very high level of hCG, an abnormally high uterine artery pulsatility index (PI) had lower sensitivity and negative predictive value than early diastolic notch, whereas the specificity and positive predictive value were higher for a high uterine artery PI. CONCLUSIONS: These findings suggest an association between a high level of maternal serum beta-hCG at 15-18 weeks, the presence of an early diastolic notch in the uterine artery flow velocity waveform and adverse pregnancy outcome due to abnormal development of the uteroplacental circulation. Young women with an unexplained high beta-hCG level would benefit, apart from detailed sonography of the fetus and/or karyotyping, from uterine Doppler investigation and counselling about the follow-up and management of placenta-related pregnancy disorders.  (+info)

Arteriovenous malformation of mesosalpinx associated with a 'vanishing' ectopic pregnancy: diagnosis with three-dimensional color power angiography. (7/497)

We describe two cases of pelvic arteriovenous malformation diagnosed with the aid of three-dimensional color power angiography. In both cases, beta-human chorionic gonadotropin (beta-hCG) increased to significant levels (8413 and 1560 mIU/ml, respectively); however, neither an intrauterine nor an adnexal gestational sac could be found. In each case, we observed an adnexal mass with several tortuous areas exhibiting abundant turbulent flow. The diagnosis of arteriovenous malformation was made and further assessment by three-dimensional color power angiography and magnetic resonance imaging (MRI) was carried out. The complex vascular anatomy of arteriovenous malformation, including its feeding vessels and drainage, was clearly depicted by three-dimensional color power angiography and correlated well with magnetic resonance angiography. Levels of beta-hCG decreased in subsequent tests, and eventually became negative 2-3 months later without and intervention. We believe that an involutional ectopic pregnancy induced the rapid growth of the arteriovenous malformations within the mesosalpinx. Three-dimensional color power angiography can be performed quickly and easily, using existing ultrasound equipment. It improves our understanding of complicated vasculature, and thus is a useful adjunct to two-dimensional and color Doppler ultrasound in the diagnosis of arteriovenous malformation.  (+info)

Cervical pregnancy--a conservative stepwise approach. (8/497)

A case of cervical pregnancy resistant to intramuscular methotrexate therapy is presented, which was successfully treated by intra-arterial methotrexate followed by selective prophylactic hypogastric artery embolization to avoid aggravating the vaginal bleeding. It is suggested that, in cervical pregnancies in which fertility preservation is desired, a stepwise conservative approach should be applied before resorting to surgical intervention.  (+info)

*Chorionic gonadotropin beta

... chorionic gonadotropin". Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin ... Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ... "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492-9. PMID 6194155 ...

*CGB2 (gene)

"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1984). "The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19". Hum. Genet. 67 (2): 174-177 ... 1997). "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. ...

*CGB1

"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene ... 1985). "Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta". Nucleic ... Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ...

*CGB7

"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... 1990). "Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer ... Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene ... "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". J. Biol. Chem. 250 (13): 5247-58 ...

*Luteinizing hormone beta polypeptide

Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1994). "Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human ... "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit ... In equids the beta subunit polypeptides of luteinizing hormone and chorionic gonadotropin are identical in sequence, differing ...

*Immunocontraception

... beta-subunit of human chorionic gonadotropin linked to tetanus toxoid". Fertil Steril. 34 (4): 328-35. doi:10.1016/s0015-0282( ... "Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma". Gut. 42: 88-91. doi: ... neuroendocrine tumors exclusively produce human chorionic gonadotropin a-subunit (hCGa)". Hum Pathol. 31: 966-972. Louhimo, J; ... "A novel human cancer vaccine elicits cellular responses to the tumor-associated antigen, human chorionic gonadotropin b". Clin ...

*Human chorionic gonadotropin

"Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary". J. Clin. ... beta) subunit that is unique to hCG. The α (alpha) subunit is 92 amino acids long. The β-subunit of hCG gonadotropin (beta-hCG ... Gregory JJ, Finlay JL (April 1999). "Alpha-fetoprotein and beta-human chorionic gonadotropin: their clinical significance as ... Equine chorionic gonadotropin Gonadotropin preparations Human placental lactogen Triple test - a screening test in pregnancy ...

*Pregnancy test

Most chemical tests for pregnancy look for the presence of the beta subunit of human chorionic gonadotropin (hCG) in the blood ... The first of these markers to be discovered, human chorionic gonadotropin (hCG), was discovered in 1930 to be produced by the ... Selmar Aschheim and Bernhard Zondek introduced testing based on the presence of human chorionic gonadotropin (hCG) in 1928. ... Quantitative blood (serum beta) tests can detect hCG levels as low as 1 mIU/mL, while urine test strips have published ...

*Glycoprotein hormones, alpha polypeptide

"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". The Journal of Biological ... Bellisario R, Carlsen RB, Bahl OP (Oct 1973). "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit". ... The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), ... cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin". Nature. 281 (5730): 351-6. ...

*CGB5

... monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene". Molecular Endocrinology. 17 (1): 11-26. ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin ( ... Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ... "No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women". Endocrine. 34 (1-3): 117- ...

*List of MeSH codes (D06)

... chorionic gonadotropin MeSH D06.472.351.326.125 --- chorionic gonadotropin, beta subunit, human MeSH D06.472.351.326.562 --- ... chorionic gonadotropin MeSH D06.472.699.649.367.125 --- chorionic gonadotropin, beta subunit, human MeSH D06.472.699.649. ... chorionic gonadotropin MeSH D06.472.759.367.125 --- chorionic gonadotropin, beta subunit, human MeSH D06.472.759.367.562 --- ... beta subunit MeSH D06.472.699.631.525.343.288.625 --- follicle stimulating hormone, human MeSH D06.472.699.631.525.343.288.750 ...

*List of MeSH codes (D23)

... chorionic gonadotropin, beta subunit, human MeSH D23.101.840.375 --- hormones, ectopic MeSH D23.101.840.400 --- ki-67 antigen ... human platelet MeSH D23.050.705.230 --- blood group antigens MeSH D23.050.705.230.031 --- abo blood-group system MeSH D23.050. ... transforming growth factor beta MeSH D23.348.479.996 --- wnt proteins MeSH D23.348.479.996.500 --- wnt1 protein MeSH D23.348. ... transforming growth factor beta MeSH D23.469.050.050 --- angiotensins MeSH D23.469.050.050.025 --- angiotensin i MeSH D23.469. ...

*Giant-cell carcinoma of the lung

GCCL have been long known for secretion of the beta subunit of human chorionic gonadotropin (beta-HCG), often in large amounts ... Yaturu S, Harrara E, Nopajaroonsri C, Singal R, Gill S (2003). "Gynecomastia attributable to a human chorionic gonadotropin- ... Dailey JE, Marcuse PM (August 1969). "Gonadotropin secreting giant cell carcinoma of the lung". Cancer. 24 (2): 388-96. doi: ... "A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer ...

*List of MeSH codes (D12.644)

... chorionic gonadotropin MeSH D12.644.548.726.367.125 --- chorionic gonadotropin, beta subunit, human MeSH D12.644.548.726. ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 --- gtp-binding protein gamma subunits MeSH D12.644.360.375.940 --- ... alpha subunit MeSH D12.644.548.691.525.343.463.500 --- luteinizing hormone, beta subunit MeSH D12.644.548.691.525.343.583 --- ... beta subunit MeSH D12.644.548.691.525.343.288.750 --- glycoprotein hormones, alpha subunit MeSH D12.644.548.691.525.343.463 ...

*Thyroid-stimulating hormone

... the alpha and the beta subunit. The α (alpha) subunit (i.e., chorionic gonadotropin alpha) is nearly identical to that of human ... The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The β chain has a 118-amino ... chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The α subunit is thought to be ... receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse ...

*Gestational trophoblastic disease

But GTD also leads to elevated serum hCG (human chorionic gonadotropin hormone). Since pregnancy is by far the most common ... the beta subunit of hCG (beta hCG) is also always elevated. Therefore, if GTD is clinically suspected, serum beta hCG is also ... This tissue may grow at the same rate as a normal pregnancy, and produces chorionic gonadotropin, a hormone which is measured ... Placental site nodules are lesions of chorionic type intermediate trophoblast, usually small. 40 to 50% of placental site ...

*Luteinizing hormone

... and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits, labeled alpha and beta subunits, ... "Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone and human follicle-stimulating hormone on ... This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both ... The beta subunits vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is ...

*Follicle-stimulating hormone

... and human chorionic gonadotropin (hCG). The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist ... while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids ( ... C. (1998-04-28). "Gonadotropin-Releasing Hormone Regulation of Gonadotropin Subunit Gene Expression in Female Rats: Actions on ... In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3. It is expressed in two cell types, most ...

*FSHB

Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded ... chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a ... of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. ... "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human ...

*Gonadotropin

... and hence that synthesis of alpha and beta is independently regulated. Another human gonadotropin is human chorionic ... These subunits are heavily modified by glycosylation. The alpha subunit is common to each protein dimer (well conserved within ... and placental/chorionic gonadotropins human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), as well as at ... Laurence A. Cole (21 September 2010). Human Chorionic Gonadotropin (hCG). Elsevier. pp. 205-. ISBN 978-0-12-384908-3. ...

*Fertile eunuch syndrome

Testicular effects of isolated luteinizing hormone deficiency and reversal by long-term human chorionic gonadotropin treatment ... Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone N Engl J Med. 1992; 326(3): ... Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. N Engl J Med. 2004; 351(25):2619-25. ... full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total ...

*Sp4 transcription factor

"Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement ... Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB (Jul 2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a ... "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin ... "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of ...

*Luteinizing hormone/choriogonadotropin receptor

The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a ... "A receptor-binding region in human choriogonadotropin/lutropin beta subunit". Proceedings of the National Academy of Sciences ... interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species". Molecular Endocrinology. 5 ( ... in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin". ...

*Nuggehalli Raghuveer Moudgal

Follicle-stimulating hormone Human chorionic gonadotropin Bonnet macaque Folliculogenesis India portal Medicine portal His ... "Passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion-a ... He was a member of the task force of the World Health Organization for research in human reproduction for a number of years, ... He was known for his pioneering researches on gonadotropin and was an elected fellow of the Indian Academy of Sciences and the ...

*Amyloid precursor protein

"Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic ... "The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and ... gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include presenilin ... The pregnancy hormone human chorionic gonadotropin (hCG) increases AβPP expression and hESC proliferation while progesterone ...

*Index of biochemistry articles

... chorionic gonadotropin - chromatid - chromatin - ciclosporin - Chromatography - Chromosomal crossover - chromosome - chromosome ... beta-2 microglobulin - beta adrenergic receptor - beta sheet - beta-1 adrenergic receptor - beta-2 adrenergic receptor - beta- ... protein subunit - protein synthesis - protein targeting - protein translocation - protein-tyrosine kinase - protein-tyrosine- ... Human Genome Project - hybridization - hydrocarbon - Hydrogen - Hydrogen bond - hydrogenation - hydrogen-deuterium exchange - ...
Beta-hCG ELISA kit is a reliable quantitative procedure for measuring beta human chorionic gonadotropin (beta-hCG) in serum samples. • Reactivity: Human
TY - JOUR. T1 - Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital. AU - Varashree, B. S.. AU - Belle, Vijetha Shenoy. AU - Krishnananda Prabhu, R. V.. AU - Rao, Pragna. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with ...
BACKGROUND Medical treatment of the rare interstitial ectopic pregnancy with methotrexate has been considered an alternative to surgical resection. AIM To determine the treatment success rate with a single-dose intravenous methotrexate/folinic acid regimen and to identify predictors of treatment outcome. METHODS A 5-year audit (April 2000-August 2005) was carried out, collecting clinical imaging data and serum beta-human chorionic gonadotrophin (beta-hCG). Time taken for complete beta-hCG resolution was recorded, and a negative beta-hCG result was used as an endpoint of successful outcome. RESULTS Of the 13 cases, two required urgent surgery for rupture on presentation. In the remaining 11 cases, intravenous methotrexate (300 mg) was used, with oral folinic acid rescue (15 mg x 4 doses). There were no side-effects. Complete beta-hCG resolution was achieved in 10 of the 11 medically treated cases (91% success rate), requiring 21-129 days. Successful outcome was seen with initial beta-hCG level as
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BACKGROUND: Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It is associated with later development of type 2 diabetes, the risk of macrosomia and other long-term health effects of infants born to diabetic mothers. The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women. MATERIAL AND METHODS: A total of 200 pregnant women were recruited for the study, 150 pregnant women without pre gestational diabetes including 50 women with low risk factors of diabetes as controls and 50 other pregnant women with pregestational diabetes as control ...
Beta hCG Test Definition - A beta hCG test is a blood test that monitors levels of the hormone human chorionic gonadotropin (hCG) present in the body....
HCG levels are often measured as part of a maternal serum triple or quadruple screening test. These tests are done by measuring three or four substances in a womans blood and are used to estimate the babys risk of certain problems or congenital birth defects. The triple screen measures beta human chorionic gonadotropin (beta-HCG), alpha-fetoprotein (AFP), and a type of estrogen (unconjugated estriol or uE3). The quad screen measures the hormone inhibin-A in addition to the other three.. Abnormal HCG levels do not necessarily mean that there is a problem. It could simply be due to a miscalculation of pregnancy dating. Unfortunately though, abnormal HCG levels could also indicate a more serious issue. There are several things that could cause a high or low HCG level, so you should be retested within a few days to see how the levels are changing.. A high HCG level could be an indicator of a multiple pregnancy, in which there is more than one fetus present, or a molar pregnancy. A low HCG level ...
A few of their stories appeared in this research publication. Rumors also say that the Child Gender Prediction Chart had been studied by the Chinese Academy of Sciences Research Center. You may really feel over the moon then down within the dumps inside minutes. Thus, if a patient has a historical past of endometriosis or different tubal illness, an HSG would be most well-liked. After an intensive evaluation, theres a lot that physiotherapists can do that can beta hcg level for multiple pregnancy you together with your pregnancy-related back ache. the bleeding took 6 days beta hcg level for multiple pregnancy i tried once more proper interval usually begins on the fifth of every month(common). By sixth week the childs coronary heart begins to beat and by eighth week the fetus develops rudimentary limbs. There isnt a need to attempt to prevent white discharge, as this can be a regular process that happens in each and every girl. Together with feeling nauseous!. Their solely authorized concern ...
Human chorionic gonadotropin (hCG) is a glycoprotein hormone (molecular weight: MW approximately 36,000 Dalton: Da) consisting of 2 noncovalently bound subunits. The alpha subunit (92-amino acids; "naked" protein MW 10,205 Da) is essentially identical to that of luteinizing hormone (LH), follicle-stimulating hormone, and thyroid-stimulating hormone (TSH). The alpha subunit is essential for receptor transactivation. The different beta subunits of the above hormones are transcribed from separate genes, show less homology, and convey the receptor-specificity of the dimeric hormones. The chorionic gonadotropin, beta gene (coding for a 145-amino acid, "naked" protein MW 15,531 Da, glycosylated subunit MW approximately 22,500 Da) is highly homologous to the beta subunit of LH and acts through the same receptor. However, while LH is a classical tropic pituitary hormone, hCG does not usually circulate in significant concentrations. In pregnant primates (including humans) it is synthesized in the ...
Being pregnant checks work by detecting a pregnancy hormone known as beta-human chorionic gonadotrophin (hCG), which shall be in your urine for those whore pregnant. Studies present that nearly 20 of girls with belly cramping end in miscarriage. Some girls fear that the pain associated with an induced labor is likely to be worse than the ache related to labor that begins by itself. Its fully normal but in rare circumstances, it could be a symptom of a pulmonary embolism, coronary heart disease or lung illness. An at home practical pregnancy and parenting fertility test is a straightforward method to blood tests for pregnancy time for results out if hes having sperm issues. Tender, swollen breasts are one of many early pregnancy symptoms. The medications youve got taken and maybe are taking can have an effect on your menstrual and ovulation cycle, which can be why you mayt get pregnant. autism spectrum disorder (ASD) and a spotlight deficit hyperactivity disorder (ADHD)) is understood about ...
ACCESS INFORMATION PRIOR TO THIS POST ON BETA β-hCG (human chorionic gonadotropin) is a glycoprotein that is initially secreted by trophoblast cells in
Beta hCG database, levels chart, scatter plot and doubling time calculator by days after ovulation, IVF embryo transfer and missed period in early pregnancy.
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Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
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This past month could have produced a tension filled, emotionally charged blog to follow. I didnt have the heart to do it. At 5 weeks 3 days I started bleeding. A gush of blood in the toilet. My OB had me go in to her office for a urine test, and a beta hcg draw. My HCG number was fine. It had doubled up as expected from the previous draw at 15 days past ovulation. My urine tested clear for infection. I was sent home. Another small gush of blood as I was preparing steaks for the oven that evening. My husband came home and we took a taxi to the hospital. My HMO has recently consolidated its former 2 emergency rooms to one. The waiting room was packed with about 50 people. I was triage after about an hour and a half. Nobody was being called back. More people kept checking in. I was seen by a doctor nearly 7 hours after I arrived. By that time I was hungry and terrified that I was losing my pregnancy. An ultrasound showed nothing visible in my uterus. There should have been a measurable sac. The ...
2 Tumour tests are available from Thyrocare. These serve as cancer risk markers and help you in detection of early cancer detection. Tumour Pane for Male is Rs.1500 and for Female Rs.1880. Tests covered are CA 19.9, CEA, Beta HCG, AFP, CA 125, PSA and more.
Thank you for your reply. My first hpt faint positive was yesterday on day 11.5 and my blood test hcg beta was a 5 today on day 12.5. Because of July 4th and clinics and labcorp being closed...I must wait until Thursday to do the next blood test. Ive been reading on the internet and managed to only find 2 positive stories...one with a girl who had a 4 and one with a 5 who had live births...but I know it doesnt look good ...
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OBJECTIVES: To evaluate the performance of first-trimester screening for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A). In addition, the potential impact of a new individual risk-orientated two-stage approach to first-trimester screening was ...
Objective To establish an algorithm for first-trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks gestation and ultrasound testing at 11-13 weeks. Methods This was a multicenter study of 886 pregnancies with trisomy 21 and 222 475 unaffected pregnancies with measurements of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 7-14 weeks gestation. Multiple regression modeling of log-transformed marker values was used to produce log multiples of the median (MoM) values for PAPP-A and free beta-hCG. The models included terms for the center attended and the machine used for biochemical analysis, gestational age, maternal racial origin, maternal weight, smoking status and method of conception. Bivariate Gaussian distributions were fitted to log MoM PAPP-A and log MoM free beta-hCG in trisomy 21 and in unaffected pregnancies. In each case the patient-specific risk for trisomy 21 was estimated by multiplying the ...
Women of childbearing potential must have negative serum beta human chorionic gonadotropin (beta-HCG) pregnancy tests performed within 21 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on weekends, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (beta-HCG) pregnancy test will be performed upon completion of the study ...
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Women of childbearing potential must have negative serum beta human chorionic gonadotropin (beta-HCG) pregnancy tests performed within 14 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on weekends, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (beta-HCG) pregnancy test will be performed upon completion of the study ...
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings ...
TY - JOUR. T1 - Ectopic human chorionic gonadotropin in breast carcinoma. AU - Castro, A.. AU - Buschbaum, P.. AU - Nadji, M.. AU - Voigt, W.. AU - Tabei, S.. AU - Morales, A.. PY - 1979/10/1. Y1 - 1979/10/1. N2 - Immunoreactive human chorionic gonadotropin (hCG) was found in 9 of 65 surgically removed malignant breast tumors. Concentrations ranged from 5 to greater than 500 mIU hCG/g tumor. hCG was measured by a β-chain specific radioimmunoassay. In further study of these specimens, an immunoperoxidase staining technique was used to stain for hCG in formalin-fixed sections. The hCG was shown to be localized within the cytoplasm and on the surface of the malignant cells.. AB - Immunoreactive human chorionic gonadotropin (hCG) was found in 9 of 65 surgically removed malignant breast tumors. Concentrations ranged from 5 to greater than 500 mIU hCG/g tumor. hCG was measured by a β-chain specific radioimmunoassay. In further study of these specimens, an immunoperoxidase staining technique was used ...
Pregnancy-associated plasma protein-A2 (PAPP-A2, pappalysin-2) is a large metalloproteinase, known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in chordamesoderm, notochord, and lower jaw of zebrafish (Danio rerio) embryos, and that papp-a2 knockdown embryos display broadened axial mesoderm, notochord bends, and severely reduced cranial cartilages. Genetic data link these phenotypes to insulin-like growth factor binding protein-3 (Igfbp-3) and Bmp signaling, and biochemical analysis show specific Igfbp-3 proteolysis by Papp-a2, implicating Papp-a2 in the modulation of Bmp signaling by Igfbp-3 proteolysis. Knockdown of papp-a2 additionally resulted in angiogenesis defects, strikingly similar to previous observations in embryos with mutations in components of the Notch system. Concordantly, we find that Notch signaling is modulated by Papp-a2 in vivo, and, furthermore, that PAPP-A2 is capable of modulating Notch ...
Once human chorionic gonadotropin hormone levels are between 1000 and 2000 U/ml a transvaginal ultrasound can be carried out to show the gestational sac. hCG levels can change and the date of conception may be incorrect. When the hCG levels have reached a minimum of 2000 only then would the information from the ultrasound be considered in making a diagnosis.. To make sure that you receive an accurate diagnosis, lots of hCG tests would be carried out over a period of days. By doing the tests a few days apart any questions about the pregnancy will be answered more accurately. Levels of the hCG hormone levels are not used to provide any dates for pregnancy because the numbers are so varied. The two types of human chorionic gonadotropin testings are:. ...
my son I did not even early signs of pregnancy hard nipples I was pregnant until I used to be 18 wks as monthly cycle hadnt gone again to normal after I had my daughter just a few mths prior. The pressure may decrease blood stream back from the legs, resulting in pooling of fluid across the ankles with swelling This will trigger cramping pain within the legs. A lady who desires to have a child ought to monitor whether or not the primary days of her beta hcg after molar pregnancy tends to return the identical number of days apart each month, which is taken into account being common. Its going to also rise slightly at completely different levels of your cycle. Pregnancyy in case you have ache throughout sex, tell your provider. The place will your bundle of pleasure sleep when she molwr dwelling. An analysis of the persons semen needs to be performed before the feminine accomplice undergoes any invasive testing. Some consultants says bbeta there are ladies who bear change in conduct. The second ...
... Definition Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone, which similar in structure to luteinizing hormone tha
Tests involving 2 markers in combination with maternal age - specifically PAPP-A (pregnancy-associated plasma protein A), free beta-hCG (beta-human chorionic gonadotropin) and maternal age - were significantly better than those involving single markers, with and without age. They detected 7 out of 10 Down-affected pregnancies (3 in 10 were missed), and a fixed 5% of all tested women got a false-positive result. The addition of further markers (triple tests) was not shown to be statistically superior; the studies included were small, with limited power to detect a difference. The screening blood tests themselves had no adverse effects for the woman, over and above the risks of a routine blood test ...
HCG hormone (Aka Human Chorionic gonadotropin) is a hormone produced in pregnancy by the developing placenta. HCG informs the body that a pregnancy has happened and tells it to start secreting hormones to support the pregnancy and stop producing...
Monoclonal antibody to Human Chorionic Gonadotropin hCG. Two clones (4D9 and 7H2) recognize hCG and hCG subunit beta. Size: 0.5 mg or 2 x 0.5 mg.
Human chorionic gonadotropin (medically abbreviated to hCG) is a hormone that is produced by the placenta during pregnancy. It helps to keep the pregnancy going and also has an effect on the development of the baby.
The hCG hormone better known as Human Chorionic Gonadotropin is produced at the time of pregnancy. It is constructed by those cells which form the placenta, nourishes the fertilized egg and then attaches to the uterine wall.
Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice.: Human CG is a pregnancy marker secreted by the placenta
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Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.. Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your childs condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.. For childhood extracranial germ cell tumors, alpha-fetoprotein (AFP) tests and beta-human chorionic gonadotropin (β-hCG) tests are done to see if treatment is working. Continued high levels of AFP or β-hCG may mean the cancer is still growing. For at least 3 years after surgery, follow-up will include regular physical exams, imaging tests, and tumor marker tests.. ...
Ashley is a 24 year old woman who started the Dr. Simeons HCG Protocol earlier this year. Her height is 59″ and her starting weight was 230 lbs. She chose to inject the HCG (human chorionic gonadotrophin) intramuscularly daily for six weeks at a time.. After completing six weeks at the beginning of April 2009 she had lost 31 lbs and weighed 199 lbs.. At the end of May 2009 she started another round of HCG treatment and when she followed up in the office today she had lost another 20.2 lbs in 21 days. Today her weight was 178.2 lbs. She plans to complete a full six week round and then take a break for a while.. As Ashley started to lose weight she first lost most of the abnormal fat deposits in her upper body, including her face, chest, arms, and abdomen. Her hips and thighs were not reducing much initially. However, during the last round of treatment she noticed significant reductions in her hips and thighs.. Considerations for future treatment, besides HCG, include MIC injections for general ...
The patient is a healthy 80yrs old male with a large, right, painless scrotal swelling that has progressed in size slowly for many years. The following tumor biomarkers were performed and found to be negative: AFP, LDH, betaHCG. Scrotal ultrasound demonstrated a right paratesticular mass without involvement of testis.. ...
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5 untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008 ...
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A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
Choragon injections contain the active ingredient chorionic gonadotrophin, which is a natural sex hormone also known as human chorionic gonadotropin or HCG.
... definition, Also called human chorionic gonadotropin. Biochemistry. a hormone, produced in the incipient placenta of pregnant women, that stimulates the production of estrogen and progesterone: its presence in blood or urine is an indication of pregnancy. See more.
Calculate the doubling time of two beta hCG samples and check whether your hCG levels in pregnancy rise normally by using Our hCG Pregnancy Hormone Calculator.
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Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Nemiro on testing hcg levels: Serum is the part of blood. It is the liquid part left when blood clots and is centrifuged . Many blood tests, including beta HCG are done on serum.
If I had known nothing about hcg levels in early pregnancy when I finally got the call from the nurse at 2 p.m. yesterday afternoon (having mentally concocted worse and worse scenarios the longer I waited), I probably wouldnt be that worried. She said a 60% increase is "fine" and that they wanted to see me back on Friday morning "just to make sure everything is on track." Not so bad, right? A consult with Dr. Google (Yes, I admit it: I could not resist the urge. I am weak.) confirmed that in a normal pregnancy beta hcg levels double every 48-72 hours, and an increase of 60% or above over 48 hours is still considered normal ...
Alhamdulillah.. Syukur padaNya kerana pada 4 February 2014 lepas genap umur saya 29 tahun. Tahun ni last nak enjoy2 sbg 20s sebelum usia masuk 3 series tahun depan.. hahaha.... Tahun ni just celebrate kat hospital sbb lepas ET tu sy kena warded utk bedrest.. Mmg ni satu pengalaman dan sejarah dalam hidup saya.. Husben belikan 2 slices kek secret recipe.. hehe... Utk hadiah ulang tahun kelahiran ini saya cuma mengharapkan hadiah yg paling bermakna dlm hidup iaitu positif beta hcg dan sekaligus merealisasikan impian kami utk menjadi ibu dan ayah.. Semoga Allah permudahkan segala urusan kami. Amin.... ...
The Alere™ hCG Combo Cassette (25 mIU/mL) is a one-step test for the early detection of human chorionic gonadotropin (hCG), a hormone produced during pregnancy.
The Alere™ hCG Cassette (25 mIU/mL) is a one-step test for the early detection of human chorionic gonadotropin (hCG), a hormone produced during pregnancy.
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What could be HCG? What is HCG? Human chorionic gonadotropin (HCG) is a hormone that supports the normal growth and development of an egg within a womans ovary, and stimulates the launch of the egg during ovulation. HCG is used to result in ovulation also to treat infertility in women, and to increase…
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Human chorionic gonadotropin, or hCG, is a natural hormone made in the body in significant levels only during pregnancy. During pregnancy, levels of hCG...
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Question - Why did liver enzymes rise suddenly? Stopped HCG. Ask a Doctor about Human chorionic gonadotropin, Ask a Gastroenterologist
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Human chorionic gonadotropin (hCG) is a hormone produced by the placenta after implantation. The presence of hCG is detected in some …
HCG (human chorionic gonadotropin) is a natural hormone produced during pregnancy. The diet is a fraction of the amount produced during pregnancy.
Question - How can I determine pregnancy? Have discharge, thick; red blood. Suggest. Ask a Doctor about Human chorionic gonadotropin, Ask a General & Family Physician
Buy Ovidac 10000 IU Injection Online Human chorionic gonadotropin, which is the primary constituent of Ovidac 10000 IU Injection, is obtained from the placental cells of pregnant women and is used to treat infertility in women and men. It is also used to treat delayed puberty issues in children. Ovidac 10000 i.u. is used for medical conditions such as infertility.
Another strange obesity cure that was popular among physicians for a time was human chorionic gonadotropin (HGC), a type of growth hormone that was injected into patients. This treatment became popular...
I had my 3 day embryo transferred on 19/9/15 and did my bhcg test on 28/9/15 which came negative i.e 3 mIu/ml .As per doctors instructions i was supposed to check my blood on 29/9/15. I got a little spotting on the 2nd day after my transfer when i reported to doc she dint sound positive about it but however I thought it could possibly be an implantation bleeding.Was it too early that I checked my bhcg because the last time i had checked a few months back it was only 0.5 mIu/ml .Should I consider this as a negative or are there cases where first blood test was negative then it became positive ? My husband and I are still in hopes. Any such experiences Please share ...
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Looking for online definition of Chorionic gonadotropin, beta subunit, human in the Medical Dictionary? Chorionic gonadotropin, beta subunit, human explanation free. What is Chorionic gonadotropin, beta subunit, human? Meaning of Chorionic gonadotropin, beta subunit, human medical term. What does Chorionic gonadotropin, beta subunit, human mean?
TY - JOUR. T1 - Analytical versus clinical sensitivity and specificity in pregnancy testing. AU - Emancipator, Kenneth. AU - Cadoff, Evan M.. AU - Burke, M. Desmond. PY - 1988/3. Y1 - 1988/3. N2 - A typical urine pregnancy test with the enzyme-linked immunoassay for human chorionic gonadotropin (Tandem Icon human chorionic gonadotropin) was performed as was a qualitative serum radioimmunoassay for human chorionic gonadotropin when the positive cutoff for the latter was set at 30 IU/L. There was 99.5% concordance between the two methods when performed on 871 simultaneous urine and serum specimens. Although the serum radioimmunoassay can detect levels of human chorionic gonadotropin as low as 10 IU/L, in this study the majority of patients with serum levels between 10 and 30 IU/L were not pregnant on clinical follow-up. Of nine patients with adequate clinical follow-up, a negative urine pregnancy test result, and a serum human chorionic gonadotropin level between 10 and 30 IU/L, only one proved to ...
Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Plasma-membrane and soluble fractions containing human chorionic gonadotropin/lutropin receptor were prepared from bovine corpora lutea by ultracentrifugation. The plasma-membrane and soluble fractions were studied for physicochemical properties, salts and gangliosides. The receptor preparations obtained from the plasma-membrane purified individually by sucrose-density-gradient centrifugation, which resulted in a partial dissociation of the hormone-binding subunit from the intact functional receptor unit, which consists of both hormone-binding (regulatory) and adenylate cyclase-associated (catalytic) subunits. The fractions containing the functional receptor unit were further purified by gel filtration on Sepharose-6B and chromatography on concanavalin A-Sepharose. The receptor was finally purified by affinity chromatography on a column of controlled-pore glass covalently coupled to hu man chorionic gonadotropin. The purified receptor from the plasma-membrane and the soluble fractions ...
The placenta secretes chorionic gonadotropin beginning just after implantation. This glycoprotein consists of two chains. The α-chain is identical to the α-chains of three pituitary hormones - luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH). The β-chain is unique to gonadotropin. Signaling through its receptor, human chorionic gonadotropin (HCG) maintains the corpus luteum and causes it to secrete progesterone. Because HCG is usually secreted within seven days after conception, and because serum levels double every 2-3 days for the first two months of pregnancy, its presence in urine is the basis of home pregnancy tests. It is also used in fertility treatments. The β-chain is secreted by some tumors and its presence in urine can indicate testicular cancer. Most of our HCG products are purified from pregnancy urine, and are available in several formulations, including convenient vials of sterile filtered lyophilized powder standardized by HCG units.
Nonomura, A., Mizukami, Y., Matsubara, F., Izumi, R., Nakanuma, Y., Hayashi, M., Watanabe, K. and Takayanagi, N. (1989), Human chorionic gonadotropin and alpha-fetoprotein in cholangiocarcinoma in relation to the expression of ras p21: an immunohistochemical study. Liver, 9: 205-215. doi: 10.1111/j.1600-0676.1989.tb00401.x ...
The X-ray structure of a ternary complex between human chorionic gonadotropin hormone (hCG) and two Fvs recognizing its α and β subunits has been recently determined. The Fvs recognize the elongated hCG molecule by its two ends, one being the Leu-12-Cys-29 loop of the α subunit. We have designed and synthesized a 17-amino-acid peptide (named PepH14) derived from the sequence of this antigenic loop with the purpose of mimicking its three-dimensional structure and its affinity for antibodies. We have determined the solution structure of PepH14 by homonuclear NMR spectroscopy and derived distance restraints. Comparison of this structure with that of the corresponding antigenic loop of α-hCG reveals strong conformational similarities. In particular, the two pairs of residues that establish crucial contacts with the Fv fragment share the same conformation in PepH14 and in the authentic hormone loop. We propose a three-dimensional model of interaction of PepH14 with a llama VHH (VHH-H14) fragment ...
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If you have not had a D&C done, you may still feel pregnant until your hormones return to pre-pregnancy level. You may still feel pregnant for a few days to a week after you miscarry. Emotionally it may take longer to stop feeling pregnant. If you continue to have pregnancy symptoms you should talk to your doctor.. Two ways that doctors diagnose miscarriage are by checking quantitative beta-HCG levels and by doing an ultrasound. In early pregnancy beta-HCG levels should double every two to three days. One blood test is not enough to determine miscarriage. Your doctor may order two to three beta-HCG tests to see if your levels are rising appropriately. Even if they are rising slowly there is cause for concern. Slow rising HCG levels usually result in miscarriage or can be a sign of an ectopic pregnancy. Another way doctors diagnose miscarriage is by doing an ultrasound. Your doctor will look for a viable fetus and check your measurements to see if they are consistent with your due date. Your ...
A compilation of information and experiences as I try to conceive my first child. After a vasectomy reversal. With poor sperm morphology. With a fibroid and after an abdominal myomectomy. Now a new mother of a cute baby boy. Documenting the better part of two miscarriages, 3-1/2 years of infertility, research and testing and my successful pregnancy and beyond.. ...
The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal circulating IGF-I levels. In this study, PAPP-A KO mice had significantly increased mean (27%), median (27%), and maximum (35%) life span compared with wild-type (WT) littermates. End-of-life pathology indicated that the incidence of [cancer] was not significantly different in the two groups of mice; however, it occurred in older aged PAPP-A KO compared with WT mice. Furthermore, PAPP-A KO mice were less likely to show degenerative changes of age. Scheduled pathologies at 78, 104, and 130 weeks of age indicated that WT mice, in general, had more degenerative changes and tumors earlier than PAPP-A KO mice. This was particularly true for abnormalities in heart, testes, brain, kidney, spleen, and thymus. In summary, the major contributors to the extended life span of PAPP-A KO mice are delayed occurrence of fatal [cancers] and decreased incidence ...
Humam chorionic gonadotropin (HCG) is either made from urine of pregnant women or hormone produced by human placenta. It is used conjunction with FSH and HMG as we mentioned in previous article.
Snookie has revealed her secrets to instant weight loss in various TV interviews.. One of the greatest secret is the Human Chorionic Gonadotropin at she has been dieting. This is on top of cutting down her alcohol intake and excising a lot. The diet regime that she has adopted has had positive rewards on her life and the lives of many other people all over the world. Nicole Snookie has been using a HCG diet like many other women in the world. HCG is a hormone that is produced by the placenta when a woman is pregnant. It usually stands for Human Chorionic Gonadotropin. This hormone is responsible for controlling the metabolic reactions or functions of a woman. It is synthetically produced and utilized in diet protocols to aid in weight loss.. Like in the case of Nicole Snookie, weight loss is rapid with HCG. It is important to note that Nicole has reported a weight loss of about 17 pounds in two months. This is compatible with data on HCG weigh loss in most programs. Most HCG dieter post that ...
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Development-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female ratsDevelopment-related changes in the expression of the ovarian Kiss1 and Kiss1r genes and their sensitivity to human chorionic gonadotropin in prepubertal female rats ...
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
Chorionic Gonadotrophin - Get up-to-date information on Chorionic Gonadotrophin side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Chorionic Gonadotrophin
Ashley is a 24 year old woman who started the Dr. Simeons HCG Protocol earlier this year. Her height is 59″ and her starting weight was 230 lbs. She chose to inject the HCG (human chorionic gonadotrophin) intramuscularly daily for six weeks at a time.. After completing six weeks at the beginning of April 2009 she had lost 31 lbs and weighed 199 lbs.. At the end of May 2009 she started another round of HCG treatment and when she followed up in the office today she had lost another 20.2 lbs in 21 days. Today her weight was 178.2 lbs. She plans to complete a full six week round and then take a break for a while.. As Ashley started to lose weight she first lost most of the abnormal fat deposits in her upper body, including her face, chest, arms, and abdomen. Her hips and thighs were not reducing much initially. However, during the last round of treatment she noticed significant reductions in her hips and thighs.. Considerations for future treatment, besides HCG, include MIC injections for general ...
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HCG is a glycoprotein hormone that is produced during pregnancy by the embryo shortly after conception and later in large amounts, by the placenta.
Detect and quantitate human chorionic gonadotropin (hCG) in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA no-wash assay.
Capralogics Inc. offers both primary and secondary polyclonal antibodies for research and discovery applications. We offer products in fields such as: Apoptosis Cell Membrane Receptors Chemokine Receptors Human Chorionic Gonadotropin
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Lukacs H, Hiatt ES, Lei ZM, Rao CV. Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats ...
Information on Middlesex University's Research Repository: a online collection of Middlesex University's research outputs
Looking for online definition of chorionic gonadotropic hormone in the Medical Dictionary? chorionic gonadotropic hormone explanation free. What is chorionic gonadotropic hormone? Meaning of chorionic gonadotropic hormone medical term. What does chorionic gonadotropic hormone mean?
10 week gestational age molar pregnancy. An echogenic mass in the uterus filled with multiple cystic structures. The patient had a betaHCG of 30000 and no other symptoms other than mild vaginal bleeding. Her previous pregnancies were unremarkable and the current one was a bit of a surprise.. I felt the imaging was consistent with an early molar pregnancy and obtained a comprehensive ultrasound from the radiology department. The report described thickened inhomogeneous appearing soft tissue material within the region of the central canal with a few scattered cystic regions. A portion of debris material possibly on the basis of clots. Opinion was possible retained products of conception on basis of a recent spontaneous miscarriage but essentially nonspecific and ectopic cant be ruled out. No mention of molar pregnancy.. Despite the lack of typical clinical symptoms I thought the ultrasound image concerning enough to get an OB-GYNE consult. The attending agreed that it looked like a molar ...
ABOUT 1000 of testicular germ-cell tumours occur in men treated for maldescended testes (Whitaker, 1970). The risk of testicular tumour in men with maldescended testes has been estimated at 35 times that of normal men (Whitaker, 1970). Recently 2 case-control studies confirmed the increased risk of testicular tumour in maldescended testes (Morrison, 1976; Henderson et al., 1979). Testicular germ-cell (TGC) tumours may be preceded by carcinoma in situ in a biopsy several years before (Skakkebaek, 1972, 1978). Raised concentrations of serum o-foetoprotein (AFP) and serum human chorionic gonadotropin : subunit (hCG) often preceded other signs of relapse in nonseminomatous TGC tumours (Waldmann & McIntire, 1974). Serum AFP and serum hCG were measured as a screen for TGC tumours in men with maldescended testes, in addition to physical examination and testicular biopsy. The histological findings of the first 50 men biopsied have recently been reported elsewhere (Krabbe et al., 1979). In this paper we report
Pregnancy Test Strips. Test Sure provides the most accurate and reliable pregnancy tests at the best value on the internet. All of our pregnancy test kits come with a 100% satisfaction guarantee or well issue a full refund of the product, so you can rest assured in the quality that well deliver.. How do Pregnancy Test Kits Work?. Pregnancy test kits work by detecting a certain hormone in the urine that is only present after fertilization. The hormone hCG (human chorionic gonadotropin) is a glycoprotein produced by the placenta after conception. HCG levels become present in the body very soon after fertilization, making it the perfect test for pregnancy early on. By testing for hCG, you can detect pregnancy as early as six days after conception.. You can purchase our pregnancy test kits either in an easy to use midstream applicator, or you can purchase the pregnancy test strips on their own. The tests are easy to use, come with easy to follow instructions, and easy to read results. ...
Glucose oxidase (GOx) and horseradish peroxidase (HRP) are important enzymes for the development of amperometric enzyme linked immunosensors. The selectivity of each enzyme towards its analyte deepens its importance in determining the sensitivity of the resultant immunosensor. In designing immunosensors that have customized transducer surfaces, the incorporation with FAD and iron based enzymes ensures that electron kinetics remains optimal for electrochemical measurement. Various different immobilization strategies are used to produce response signals directly proportional to the concentration of analyte with minimal interferences. The combination of self-assembled monolayers and supramolecular chemistry affords stability and simplicity in immunosensor design. In this work, two electrochemical strategies for the detection of human chorionic gonadotropin(hCG) is presented. This involves the modification of a gold surface with a thiolated β-cyclodextrin epichlorohydrin polymer (βCDPSH) to form a ...
Hydatidiform mole is part of a group of diseases classified as gestational trophoblastic disease, which results from an aberrant fertilization. They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that has a potential to locally invade the uterus and metastasize. Traditionally, moles have been categorized into complete or partial hydatidiform moles. Partial moles are most commonly triploid and are associated with the presence of a malformed fetus. Often partial moles are misdiagnosed as an incomplete or missed abortion of the first trimester. A case of a partial molar pregnancy with live fetus diagnosed on second trimester is reported. Hyperemesis gravidarum and hyperthyroidism were the clinical presentations. Human chorionic gonadotropin level was 1 891 264 mIU/mL. Fetal karyotype was 69, XXX. Surgical uterine evacuation was performed and the patient is in follow up. Partial molar pregnancy with a live fetus is a rare condition that
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Chorionic gonadotropin, beta subunit, human | definition of Chorionic gonadotropin, beta subunit, human by Medical dictionaryChorionic gonadotropin, beta subunit, human | definition of Chorionic gonadotropin, beta subunit, human by Medical dictionary

What is Chorionic gonadotropin, beta subunit, human? Meaning of Chorionic gonadotropin, beta subunit, human medical term. What ... beta subunit, human in the Medical Dictionary? Chorionic gonadotropin, beta subunit, human explanation free. ... Chorionic gonadotropin, beta subunit, human , definition of Chorionic gonadotropin, beta subunit, human by Medical dictionary ... human chorionic gonadotropin. (redirected from Chorionic gonadotropin, beta subunit, human). Also found in: Dictionary, ...
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IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...

Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. ... human chorionic gonadotropin beta subunit; CGB gene expression; CGB1 CGB2; ovarian cancer human chorionic gonadotropin beta ... Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer. Marta Kubiczak 1 ... "Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer." Int. J. Mol. Sci ...
more infohttp://www.mdpi.com/1422-0067/14/6/12650

IJMS  | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...

Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. ...
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Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block...Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block...

Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ...
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The Sydney eScholarship Repository: The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancerThe Sydney eScholarship Repository: The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancer

The beta-subunit of human chorionic gonadotropin (hCG-β) is elevated in a range of cancers, including high-grade serous cancer ... The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancer. ...
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hCG (Human Chorionic Gonadotropin) Intact and Beta-Subunit, Quantitative -
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Test Code SQ HCGQNT, EPIC LAB143 hCG (Human Chorionic Gonadotropin) Intact and Beta-Subunit, Quantitative Important Note. NEW ...
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SEER Training:Tumor MarkersSEER Training:Tumor Markers

Beta Subunit HCG (human chorionic gonadotropin). A serum test used as a tumor marker for choriocarcinoma. When the presence of ... Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative ... Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with ... However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients ...
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Human Chorionic Gonadotropin Is Expressed Virtually in All Intracranial Germ Cell Tumors - PubMedHuman Chorionic Gonadotropin Is Expressed Virtually in All Intracranial Germ Cell Tumors - PubMed

Human chorionic gonadotropin (hCG) production has been utilized as a diagnostic marker for germinoma with syncytiotrophoblastic ... Chorionic Gonadotropin, beta Subunit, Human / metabolism* Actions. * Search in PubMed * Search in MeSH ... Human Chorionic Gonadotropin Is Expressed Virtually in All Intracranial Germ Cell Tumors Hirokazu Takami et al. J Neurooncol. ... Human Chorionic Gonadotropin Is Expressed Virtually in All Intracranial Germ Cell Tumors Hirokazu Takami 1 , Shintaro Fukushima ...
more infohttps://pubmed.ncbi.nlm.nih.gov/25994796/?from_term=Matsutani+M&from_cauthor_id=12071636&from_pos=5

Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an AdultMixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult

... and the beta subunit of human chorionic gonadotropin (βHCG) (Figure 4). These results indicated that the majority of the ... and negative for beta subunit of human chorionic gonadotropin (βHCG) ((b): ×100). They are strongly positive for wide-spectrum ...
more infohttps://www.hindawi.com/journals/cris/2012/473790/

Piezoelectric ceramic sensor and sensor array for detection of molecular makers - Yang, MengsuPiezoelectric ceramic sensor and sensor array for detection of molecular makers - Yang, Mengsu

Beta Subunit of Human Chorionic Gonadotropin (β-HCG): The β-hCG normally is produced by the placenta. Elevated β-hCG levels ... beta subunit of human chorionic gonadotropin; PSA = prostate-specific antigen.. Adopted from: G. L. Perkins, E. D. Slater, G. K ... beta subunit of human chronic gonadotropin (β-hCG); and Prostate-Specific Antigen (PSA). ... The system is composed of multiple subunits in an array format, each subunit containing a different marker detecting component ...
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Current Perspectives in Polycystic Ovary Syndrome - American Family PhysicianCurrent Perspectives in Polycystic Ovary Syndrome - American Family Physician

PCOS = polycystic ovary syndrome; β-hCG = beta subunit human chorionic gonadotropin; TSH = thyroid-stimulating hormone; DHEAS ... PCOS = polycystic ovary syndrome; β-hCG = beta subunit human chorionic gonadotropin; TSH = thyroid-stimulating hormone; DHEAS ... Wang CF, Gemzell C. The use of human gonadotropins for the induction of ovulation in women with polycystic ovarian disease. ... Because the human effects of first-trimester use are unknown, discontinuation of therapy at the onset of pregnancy confirmation ...
more infohttps://www.aafp.org/afp/2003/0815/p697.html

Plasma progesterone kinetics following surgical treatment of ectopic pregnancies.Plasma progesterone kinetics following surgical treatment of ectopic pregnancies.

Chorionic Gonadotropin, beta Subunit, Human / blood. Fallopian Tubes / surgery. Female. Humans. Kinetics. Pregnancy. Pregnancy ... 0/Chorionic Gonadotropin, beta Subunit, Human; 57-83-0/Progesterone From MEDLINE®/PubMed®, a database of the U.S. National ...
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Use of the combined first-trimester screen result and low PAPP-A to predict risk of adverse fetal outcomes.Use of the combined first-trimester screen result and low PAPP-A to predict risk of adverse fetal outcomes.

Chorionic Gonadotropin, beta Subunit, Human / blood. Chromosome Aberrations. Congenital Abnormalities / diagnosis. Down ... 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A ... Humans. Pregnancy. Pregnancy Outcome*. Pregnancy Trimester, First. Pregnancy-Associated Plasma Protein-A / analysis*. Prenatal ...
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Testicular Cancer Workup: Approach Considerations, Imaging Studies, ProceduresTesticular Cancer Workup: Approach Considerations, Imaging Studies, Procedures

... and the beta subunit of human chorionic gonadotropin (beta-hCG). ... Human chorionic gonadotropin (hCG) , 5,000 IU/mL (1,000 ng/mL) ... Elevation of serum beta-hCG and AFP levels, alone or in combination, is not sufficiently sensitive or specific to establish the ... However, AFP, beta-hCG, and LDH levels are vital in the evaluation and management of patients with testicular cancers. They are ... Patients with pure seminoma may have elevated levels of beta-hCG but do not have elevated AFP levels. If AFP is elevated in ...
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Taxonomy term | Page 8 | New York State Department of Health, Wadsworth CenterTaxonomy term | Page 8 | New York State Department of Health, Wadsworth Center

Beta subunit of human chorionic gonadotropin (BetaHCG) modification. Method: Immunoenzymatic assay. Specimen Type: ...
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Cytosolic levels of neuron-specific enolase in squamous cell carcinomas of the lung. | CureHunterCytosolic levels of neuron-specific enolase in squamous cell carcinomas of the lung. | CureHunter

... free beta subunit of human chorionic gonadotropin (beta-HCG), CYFRA 21.1 and CA 125 in cytosol. On the cell surface we analyzed ...
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Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy - Full Text View - ClinicalTrials.govEffectiveness Of Expectant Management In The Tubal Ectopic Pregnancy - Full Text View - ClinicalTrials.gov

human chorionic gonadotropin beta subunit. expectant management. Additional relevant MeSH terms: Pregnancy, Ectopic. Pregnancy ... When the decline of beta-hCG titers was , 15% in this interval, the patient was followed with weekly dosing of β-hCG until the ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01876004?term=ectopic+pregnancy&rank=7

CGB monoclonal antibody, clone 094-10627 - (MAB4214) - Products - AbnovaCGB monoclonal antibody, clone 094-10627 - (MAB4214) - Products - Abnova

Native purified CGB from human pregnancy urine. (MAB4214) - Products - Abnova ... chorionic gonadotropin beta 3 subunit,chorionic gonadotropin beta chain,chorionic gonadotropin beta subunit ... Free beta-CG (Human) ELISA Kit. *KA2743. * CGB (Human) Cell-Based ELISA Kit ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=MAB4214

Amenorrhea in the Female Athlete: What to Do and When to WorryAmenorrhea in the Female Athlete: What to Do and When to Worry

Beta subunit of human chorionic gonadotropin to rule out pregnancy. Complete blood count and chemistry panel to rule out ... Recommended treatment is transdermal estradiol (100 mcg of 17 beta estradiol) with cyclic progesterone of 5 to 10 mg of ... axis in an otherwise anatomically and organically normal system and is characterized by a suppression of the gonadotropin- ...
more infohttps://www.healio.com/pediatrics/journals/pedann/2016-3-45-3/%7B30719711-01dd-4cd0-b051-2a1f8ced66d6%7D/amenorrhea-in-the-female-athlete-what-to-do-and-when-to-worry

Pelvic Pain - Gynecology and Obstetrics - Merck Manuals Professional EditionPelvic Pain - Gynecology and Obstetrics - Merck Manuals Professional Edition

Beta-hCG = beta subunit of human chorionic gonadotropin.. Nongynecologic disorders. Nongynecologic disorders that can cause ... By David H. Barad, MD, MS, Director of Assisted Reproductive Technology, Center for Human Reproduction ...
more infohttp://www.merckmanuals.com/en-pr/professional/gynecology-and-obstetrics/symptoms-of-gynecologic-disorders/pelvic-pain

CGB2 Gene - GeneCards | CGB2 Protein | CGB2 AntibodyCGB2 Gene - GeneCards | CGB2 Protein | CGB2 Antibody

Chorionic Gonadotropin Subunit Beta 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The ... The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are ... CGB2 (Chorionic Gonadotropin Subunit Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=CGB2

CGB1 Gene - GeneCards | CGB1 Protein | CGB1 AntibodyCGB1 Gene - GeneCards | CGB1 Protein | CGB1 Antibody

Chorionic Gonadotropin Subunit Beta 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The ... The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are ... CGB1 (Chorionic Gonadotropin Subunit Beta 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=CGB1

U.S. Selected Practice Recommendations for Contraceptive Use, 2013U.S. Selected Practice Recommendations for Contraceptive Use, 2013

Disappearance of human chorionic gonadotropin and its alpha- and beta-subunits after term pregnancy. Clin Chem 1997;43:2155-63. ... The sensitivity of a pregnancy test is defined as the concentration of human chorionic gonadotropin (hCG) at which 95% of tests ... Human chorionic gonadotropin in maternal plasma after induced abortion, spontaneous abortion, and removed ectopic pregnancy. ... Human chorionic gonadotropin tests. Expert Rev Mol Diagn 2009;9:721-47. ...
more infohttps://www.cdc.gov/mmwr/preview/mmwrhtml/rr6205a1.htm

Chorionic gonadotropin beta - WikipediaChorionic gonadotropin beta - Wikipedia

... chorionic gonadotropin". Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin ... Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ... "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492-9. PMID 6194155 ...
more infohttps://en.wikipedia.org/wiki/Chorionic_gonadotropin_beta
  • However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated. (cancer.gov)
  • The clinical and immunological effects of a vaccine consisting of CTP37, a synthetic peptide corresponding to the COOH-terminal peptide (CTP) of beta-human chorionic gonadotropin (beta-hCG) conjugated to diphtheria toxoid, combined with CRL 1005, a novel synthetic nonionic block copolymer adjuvant, were examined. (aacrjournals.org)