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Chorionic Gonadotropin, beta Subunit, HumanChorionic GonadotropinChoriocarcinomaDisulfidesGlycoprotein Hormones, alpha SubunitPeptide FragmentsGonadotropinsLuteinizing HormoneReceptors, LHGonadotropins, EquineReceptors, GonadotropinFollicle Stimulating HormoneGonadotropins, PituitaryDictionaries, MedicalDictionaries as TopicTumor Markers, BiologicalHysterectomyNeoplasm, ResidualChoriocarcinoma, Non-gestationalUterine NeoplasmsMestranolGestational Trophoblastic DiseaseTrophoblastic NeoplasmsHydatidiform MoleTandem Repeat SequencesMolecular Sequence DataTandem Mass SpectrometryAmino Acid SequenceBase SequenceH(+)-K(+)-Exchanging ATPaseNiobiumCeramicsTransducersEquipment DesignBiosensing TechniquesMicro-Electrical-Mechanical SystemsEquipment Failure AnalysisTesticular NeoplasmsNeuroblastomaSeminomaDysgerminomaNeoplasms, Germ Cell and EmbryonalHistory, 20th CenturySertoli Cell TumorPregnancy, TubalPregnancy, EctopicSalpingostomySalpingectomyAbortifacient Agents, NonsteroidalInjections, IntramuscularFallopian Tubes
Chorionic Gonadotropin, beta Subunit, Human
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
Chorionic Gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Choriocarcinoma
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Disulfides
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
Glycoprotein Hormones, alpha Subunit
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Peptide Fragments
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Gonadotropins
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
Luteinizing Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Receptors, LH
Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.
Gonadotropins, Equine
Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.
Receptors, Gonadotropin
Those protein complexes or molecular sites on the surfaces of gonadal and other sensitive cells that bind gonadotropins and thereby modify the functions of those cells; hCG, LH, and FOLLICLE STIMULATING HORMONE are the major specific gonadotropins.
Follicle Stimulating Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Gonadotropins, Pituitary
Hormones secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR) that stimulate gonadal functions in both males and females. They include FOLLICLE STIMULATING HORMONE that stimulates germ cell maturation (OOGENESIS; SPERMATOGENESIS), and LUTEINIZING HORMONE that stimulates the production of sex steroids (ESTROGENS; PROGESTERONE; ANDROGENS).
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Hysterectomy
Excision of the uterus.
Neoplasm, Residual
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
Choriocarcinoma, Non-gestational
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.
Uterine Neoplasms
Tumors or cancer of the UTERUS.
Mestranol
The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.
Gestational Trophoblastic Disease
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
Trophoblastic Neoplasms
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Hydatidiform Mole
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Tandem Repeat Sequences
Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
H(+)-K(+)-Exchanging ATPase
Niobium
Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)
Ceramics
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
Transducers
Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
Equipment Design
Methods of creating machines and devices.
Biosensing Techniques
Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.
Micro-Electrical-Mechanical Systems
A class of devices combining electrical and mechanical components that have at least one of the dimensions in the micrometer range (between 1 micron and 1 millimeter). They include sensors, actuators, microducts, and micropumps.
Equipment Failure Analysis
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
Testicular Neoplasms
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Seminoma
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Dysgerminoma
A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
Neoplasms, Germ Cell and Embryonal
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
History, 20th Century
Time period from 1901 through 2000 of the common era.
Sertoli Cell Tumor
Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).
Pregnancy, Tubal
The most common (>96%) type of ectopic pregnancy in which the extrauterine EMBRYO IMPLANTATION occurs in the FALLOPIAN TUBE, usually in the ampullary region where FERTILIZATION takes place.
Pregnancy, Ectopic
A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
Salpingostomy
Formation of an artificial opening in a fallopian tube.
Salpingectomy
Excision of one or both of the FALLOPIAN TUBES.
Abortifacient Agents, Nonsteroidal
Non-steroidal chemical compounds with abortifacient activity.
Injections, Intramuscular
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Fallopian Tubes
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.

The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. (1/497)

OBJECTIVE: To assess the effectiveness of non-surgical management of interstitial pregnancy. DESIGN: A prospective interventional study. SUBJECTS: Eleven women with the ultrasound diagnosis of interstitial ectopic pregnancy. METHODS: Women with suspected early pregnancy complications were examined by transvaginal ultrasound. Those with the diagnosis of interstitial pregnancy were offered non-surgical treatment with methotrexate, which was administered systemically or by local injection. Follow-up with regular measurements of beta-human chorionic gonadotropin and ultrasound scans continued until the pregnancy had resolved completely. RESULTS: Ten women were managed non-surgically, and one woman opted for surgery. Five women received systemic and five local methotrexate. Local therapy was successful in all five cases (100%), whereas four out of five (80%) women receiving systemic methotrexate were cured. Significant side-effects were noted in two women following systemic therapy. In comparison, there were no side-effects in the group of women who received local therapy. There were no significant differences between the two treatment groups in the length of time taken for the pregnancy to resolve. CONCLUSIONS: Non-surgical treatment of interstitial pregnancy with methotrexate appears to be safe and effective. Local administration appears to be more successful and better tolerated by patients and may be used as the first-line therapy.  (+info)

Combined treatment modality for intracranial germinomas: results of a multicentre SFOP experience. Societe Francaise d'Oncologie Pediatrique. (2/497)

Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Societe Francaise d'Oncologie Pediatrique initiated a study combining chemotherapy (alternating courses of etoposide-carboplatin and etoposide-ifosfamide for a recommended total of four courses) with 40 Gy local irradiation for patients with localized germinomas. Metastatic patients were allocated to receive low-dose craniospinal radiotherapy. Fifty-seven patients were enrolled between 1990 and 1996. Forty-seven had biopsy-proven germinoma. Biopsy was not performed in ten patients (four had diagnostic tumour markers and in six the neurosurgeon felt biopsy was contraindicated). Fifty-one patients had localized disease, and six leptomeningeal dissemination. Seven patients had bifocal tumour. All but one patient received at least four courses of chemotherapy. Toxicity was mainly haematological. Patients with diabetus insipidus (n = 25) commonly developed electrolyte disturbances during chemotherapy. No patient developed tumour progression during chemotherapy. Fifty patients received local radiotherapy with a median dose of 40 Gy to the initial tumour volume. Six metastatic patients, and one patient with localized disease who stopped chemotherapy due to severe toxicity, received craniospinal radiotherapy. The median follow-up for the group was 42 months. Four patients relapsed 9, 10, 38 and 57 months after diagnosis. Three achieved second complete remission following salvage treatment with chemotherapy alone or chemo-radiotherapy. The estimated 3-year survival probability is 98% (CI: 86.6-99.7%) and the estimated 3-year event-free survival is 96.4% (CI: 86.2-99.1%). This study shows that excellent survival rates can be achieved by combining chemotherapy and local radiotherapy in patients with non-metastatic intracranial germinomas.  (+info)

Hyperreactio luteinalis associated with chronic renal failure. (3/497)

Hyperreactio luteinalis is a rare benign condition characterized by bilateral ovarian enlargement associated with pregnancies where high concentrations of maternal serum human chorionic gonadotrophins are present. This condition may mimic the ovarian hyperstimulation syndrome. We report a case of a 34 year old woman with a history of chronic renal failure on haemodialysis who presented at 10 weeks' gestational age with hyperreactio luteinalis which was treated conservatively. Because of chronic renal failure, the presentation and course of the disease was different from that which has been previously reported.  (+info)

Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta. (4/497)

The primary objective of this study was to characterize an in-vitro model of the human placenta using morphological, biochemical and physiological parameters. Placental villi were obtained from normal first trimester and term pregnancies. The villi were incubated with Dulbecco's modified Eagle's medium: Ham's F12 nutrient mixture in a shaking water bath at 37 degrees C for up to 310 min. The viability was determined by the production of beta human chorionic gonadotrophin (HCG) and lactic dehydrogenase (LDH) and the incorporation of [3H]thymidine, [3H]L-leucine and L-[U14C]arginine, while ultrastructure was assessed by transmission electron microscopy. In the first and third trimester group, the release into the medium of the intracellular enzyme LDH remained unaltered throughout the experiment. By contrast, beta-HCG concentrations increased linearly and concentrations were higher in the first trimester than term villi (354.5 +/- 37.8 versus 107 +/- 8.1 IU/g villi protein; P < 0.001). Electron microscopy confirmed preservation of tissue viability for up to 4 h of incubation. The incorporation of thymidine (12.2 +/- 2.9 versus 5.2 +/- 0.5 nmol/g villi protein; P < 0.05), leucine (9.4 +/- 2.1 versus 1.9 +/- 0.4 nmol/g villi protein; P < 0.02) and arginine (17 +/- 4.4 versus 4.2 +/- 0.5 nmol/g villi protein; P < 0.05) were markedly higher in early than in term placenta. Furthermore, placental uptake of L-leucine by the first (9.4 +/- 2.1 versus 17 + 4.4 mol/g villi protein; P < 0.001) and third trimester placental villi (1.9 +/- 0.4 versus 4.2 + 0.5 mol/g villi protein; P < 0.001) was less than that of L-arginine. This study describes a simple technique using placental explants to determine relative rates of uptake of substrate amino acids throughout gestation.  (+info)

Cross-reaction with luteinizing hormone beta-core is responsible for the age-dependent increase of immunoreactive beta-core fragment of human chorionic gonadotropin in women with nonmalignant conditions. (5/497)

BACKGROUND: The beta-core fragment of human chorionic gonadotropin (hCGbetacf), also termed "beta-core" and urinary gonadotropin peptide (UGP), has been reported to be present in the urine of healthy women and to increase in concentration after menopause. This could reflect cross-reaction with the equivalent metabolite of luteinizing hormone (LH), the beta-LH-core. METHODS: We measured immunoreactive LH, hCG, free alpha-subunit, and free beta-subunit hCG (hCGbeta), as well as beta-core, using the S504 RIA and Triton UGP enzyme immunoassay in 274 urine samples from women with nonmalignant gynecological conditions. The molar cross-reaction of each assay with purified beta-LH-core was determined. RESULTS: Cross-reaction with beta-LH-core was 100% in the LH and the S504 beta-core assay, 5% in the Triton UGP assay, and <0.1% in the hCG, free alpha-subunit, and free hCGbeta assays. Median urine concentrations of all analytes showed an age-dependent increase. LH and free alpha-subunit concentrations were approximately 10(3) pmol/mol creatinine; hCG and S504 beta-core were approximately 10(2) pmol/mol creatinine; free hCGbeta and Triton UGP beta-core were in the tens of pmol/mol creatinine. The S504 beta-core concentrations were 10% of those of LH. S504 beta-core was strongly correlated with LH, but not with hCG or with free hCGbeta (LH, r2 = 0.45; hCG, r2 = 0.26; free hCGbeta, r2 = 0.03). The concentrations of beta-core detected by the Triton UGP assay, which has a 5% cross-reaction with beta-LH-core, were 2% of LH and 5% of the S504 beta-core concentrations. Triton UGP values correlated strongly with LH concentrations, but less well with S504 beta-core, intact hCG, and free hCGbeta (LH, r2 = 0.44; S504 beta-core, r2 = 0.33; hCG, r2 = 0.32; free hCGbeta, r2 = 0.19). CONCLUSIONS: Immunoreactive beta-core in women free of malignancies reflects cross-reaction with concentrations of the metabolite of LH, beta-LH-core, within the health-related reference interval.  (+info)

Perinatal outcome in pregnancies with a positive serum screening for Down's syndrome due to elevated levels of free beta-human chorionic gonadotropin. (6/497)

OBJECTIVE: To evaluate the potential clinical use of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and uterine artery Doppler investigation to screen for placenta-related adverse outcome in pregnancies at positive risk for Down's syndrome at 15-18 weeks. DESIGN: A cohort of 329 consecutive pregnant women with a singleton viable pregnancy and a positive risk for Down's syndrome was retrospectively investigated. This group was obtained from an unselected population of 3952 women attending the same hospital over a 2-year period. Using the results of this first analysis, we selected a group of 26 women with unexplained high levels of free beta-hCG and followed them prospectively with monthly ultrasound and uterine artery Doppler examinations. RESULTS: In the retrospective cohort, risk ratios stratified for maternal serum beta-hCG multiple of the median (MoM) values indicated that the highest incidence of adverse pregnancy outcome was in those women with values of > or = 5.0. In the prospective study, pregnancy outcome was complicated by uteroplacental disorders in eight cases. Analysis of the Doppler investigation indicated that, in women with a very high level of hCG, an abnormally high uterine artery pulsatility index (PI) had lower sensitivity and negative predictive value than early diastolic notch, whereas the specificity and positive predictive value were higher for a high uterine artery PI. CONCLUSIONS: These findings suggest an association between a high level of maternal serum beta-hCG at 15-18 weeks, the presence of an early diastolic notch in the uterine artery flow velocity waveform and adverse pregnancy outcome due to abnormal development of the uteroplacental circulation. Young women with an unexplained high beta-hCG level would benefit, apart from detailed sonography of the fetus and/or karyotyping, from uterine Doppler investigation and counselling about the follow-up and management of placenta-related pregnancy disorders.  (+info)

Arteriovenous malformation of mesosalpinx associated with a 'vanishing' ectopic pregnancy: diagnosis with three-dimensional color power angiography. (7/497)

We describe two cases of pelvic arteriovenous malformation diagnosed with the aid of three-dimensional color power angiography. In both cases, beta-human chorionic gonadotropin (beta-hCG) increased to significant levels (8413 and 1560 mIU/ml, respectively); however, neither an intrauterine nor an adnexal gestational sac could be found. In each case, we observed an adnexal mass with several tortuous areas exhibiting abundant turbulent flow. The diagnosis of arteriovenous malformation was made and further assessment by three-dimensional color power angiography and magnetic resonance imaging (MRI) was carried out. The complex vascular anatomy of arteriovenous malformation, including its feeding vessels and drainage, was clearly depicted by three-dimensional color power angiography and correlated well with magnetic resonance angiography. Levels of beta-hCG decreased in subsequent tests, and eventually became negative 2-3 months later without and intervention. We believe that an involutional ectopic pregnancy induced the rapid growth of the arteriovenous malformations within the mesosalpinx. Three-dimensional color power angiography can be performed quickly and easily, using existing ultrasound equipment. It improves our understanding of complicated vasculature, and thus is a useful adjunct to two-dimensional and color Doppler ultrasound in the diagnosis of arteriovenous malformation.  (+info)

Cervical pregnancy--a conservative stepwise approach. (8/497)

A case of cervical pregnancy resistant to intramuscular methotrexate therapy is presented, which was successfully treated by intra-arterial methotrexate followed by selective prophylactic hypogastric artery embolization to avoid aggravating the vaginal bleeding. It is suggested that, in cervical pregnancies in which fertility preservation is desired, a stepwise conservative approach should be applied before resorting to surgical intervention.  (+info)

Beta Human Chorionic Gonadotropin (Beta-hCG) ELISA KitBeta Human Chorionic Gonadotropin (Beta-hCG) ELISA Kit
Beta-hCG ELISA kit is a reliable quantitative procedure for measuring beta human chorionic gonadotropin (beta-hCG) in serum samples. • Reactivity: Human
http://www.elisakits.co.uk/beta-human-chorionic-gonadotropin-beta-hcg-elisa-kit/
Theca Lutein Cyst Definition, Symptoms, Causes, Diagnosis, Treatment - Health Care Tips and Natural RemediesTheca Lutein Cyst Definition, Symptoms, Causes, Diagnosis, Treatment - Health Care Tips and Natural Remedies
It is a type of ovarian cyst which occurs bilaterally. Theca lutein cyst are filled with straw colored, clear fluid. It is a functional cyst because its diameter is about 3 cm. Excessive physiological stimulation leads to the formation of theca lutein cyst. It is associated with Increased levels of hormone named beta human chorionic gonadotropin (beta HCG). Its secretion is associated with many diseases like molar pregnancy which is also known as gestational trophoblastic disease, multiple gestations, chronic kidney disease, alloimmunisation to Rh D and diabetes mellitus. These cysts are formed during pregnancy and resolves itself after pregnancy ...
http://www.healthcaretip.com/2019/03/Theca-Lutein.html
Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital<...Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital<...
TY - JOUR. T1 - Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital. AU - Varashree, B. S.. AU - Belle, Vijetha Shenoy. AU - Krishnananda Prabhu, R. V.. AU - Rao, Pragna. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with ...
https://manipal.pure.elsevier.com/en/publications/influence-of-obesity-on-first-trimester-screening-markers-in-sing
A medical management of interstitial ectopic pregnancy: a 5-year clinical study. - Semantic ScholarA medical management of interstitial ectopic pregnancy: a 5-year clinical study. - Semantic Scholar
BACKGROUND Medical treatment of the rare interstitial ectopic pregnancy with methotrexate has been considered an alternative to surgical resection. AIM To determine the treatment success rate with a single-dose intravenous methotrexate/folinic acid regimen and to identify predictors of treatment outcome. METHODS A 5-year audit (April 2000-August 2005) was carried out, collecting clinical imaging data and serum beta-human chorionic gonadotrophin (beta-hCG). Time taken for complete beta-hCG resolution was recorded, and a negative beta-hCG result was used as an endpoint of successful outcome. RESULTS Of the 13 cases, two required urgent surgery for rupture on presentation. In the remaining 11 cases, intravenous methotrexate (300 mg) was used, with oral folinic acid rescue (15 mg x 4 doses). There were no side-effects. Complete beta-hCG resolution was achieved in 10 of the 11 medically treated cases (91% success rate), requiring 21-129 days. Successful outcome was seen with initial beta-hCG level as
https://www.semanticscholar.org/paper/A-medical-management-of-interstitial-ectopic-pregn-Tang-Baartz/ecec3becfb125a79152e670f40d413f773c63202
Free Beta HCG ELISA kit | CE-GMP | 818 591 3030, USA.Free Beta HCG ELISA kit | CE-GMP | 818 591 3030, USA.
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Most recent papers with the keyword Beta human chorionic gonadotrophin | Read by QxMDMost recent papers with the keyword Beta human chorionic gonadotrophin | Read by QxMD
BACKGROUND: Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It is associated with later development of type 2 diabetes, the risk of macrosomia and other long-term health effects of infants born to diabetic mothers. The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women. MATERIAL AND METHODS: A total of 200 pregnant women were recruited for the study, 150 pregnant women without pre gestational diabetes including 50 women with low risk factors of diabetes as controls and 50 other pregnant women with pregestational diabetes as control ...
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Beta hCG Test Definition - A beta hCG test is a blood test that monitors levels of the hormone human chorionic gonadotropin (hCG) present in the body....
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HCG levels are often measured as part of a maternal serum triple or quadruple screening test. These tests are done by measuring three or four substances in a womans blood and are used to estimate the babys risk of certain problems or congenital birth defects. The triple screen measures beta human chorionic gonadotropin (beta-HCG), alpha-fetoprotein (AFP), and a type of estrogen (unconjugated estriol or uE3). The quad screen measures the hormone inhibin-A in addition to the other three.. Abnormal HCG levels do not necessarily mean that there is a problem. It could simply be due to a miscalculation of pregnancy dating. Unfortunately though, abnormal HCG levels could also indicate a more serious issue. There are several things that could cause a high or low HCG level, so you should be retested within a few days to see how the levels are changing.. A high HCG level could be an indicator of a multiple pregnancy, in which there is more than one fetus present, or a molar pregnancy. A low HCG level ...
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Human chorionic gonadotropin (hCG) is a glycoprotein hormone (molecular weight: MW approximately 36,000 Dalton: Da) consisting of 2 noncovalently bound subunits. The alpha subunit (92-amino acids; naked protein MW 10,205 Da) is essentially identical to that of luteinizing hormone (LH), follicle-stimulating hormone, and thyroid-stimulating hormone (TSH). The alpha subunit is essential for receptor transactivation. The different beta subunits of the above hormones are transcribed from separate genes, show less homology, and convey the receptor-specificity of the dimeric hormones. The chorionic gonadotropin, beta gene (coding for a 145-amino acid, naked protein MW 15,531 Da, glycosylated subunit MW approximately 22,500 Da) is highly homologous to the beta subunit of LH and acts through the same receptor. However, while LH is a classical tropic pituitary hormone, hCG does not usually circulate in significant concentrations. In pregnant primates (including humans) it is synthesized in the ...
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Being pregnant checks work by detecting a pregnancy hormone known as beta-human chorionic gonadotrophin (hCG), which shall be in your urine for those whore pregnant. Studies present that nearly 20 of girls with belly cramping end in miscarriage. Some girls fear that the pain associated with an induced labor is likely to be worse than the ache related to labor that begins by itself. Its fully normal but in rare circumstances, it could be a symptom of a pulmonary embolism, coronary heart disease or lung illness. An at home practical pregnancy and parenting fertility test is a straightforward method to blood tests for pregnancy time for results out if hes having sperm issues. Tender, swollen breasts are one of many early pregnancy symptoms. The medications youve got taken and maybe are taking can have an effect on your menstrual and ovulation cycle, which can be why you mayt get pregnant. autism spectrum disorder (ASD) and a spotlight deficit hyperactivity disorder (ADHD)) is understood about ...
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Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
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OBJECTIVES: To evaluate the performance of first-trimester screening for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A). In addition, the potential impact of a new individual risk-orientated two-stage approach to first-trimester screening was ...
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Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature | International...Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature | International...
Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. In our case, a 43-year-old woman was admitted in our hospital because she had amenorrhea for 2 months and elevated serum beta-human chorionic gonadotropin levels. The patient was considered to have an ectopic pregnancy. Initially, she was treated with methotrexate, but since there was a continuous rise in human chorionic gonadotropin levels, the patient underwent a laparoscopy, along with dilatation and curettage (D&C) of the uterine cavity. Histopathologic findings, including immunohistochemical study, led to the diagnosis of choriocarcinoma of the cervix. Finally, the patient underwent a transabdominal hysterectomy and received single agent chemotherapy with methotrexate. Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as ...
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First-trimester combined screening for trisomy 21 at 7-14 weeks gestation - Research Portal, Kings College, LondonFirst-trimester combined screening for trisomy 21 at 7-14 weeks gestation - Research Portal, Kings College, London
Objective To establish an algorithm for first-trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks gestation and ultrasound testing at 11-13 weeks. Methods This was a multicenter study of 886 pregnancies with trisomy 21 and 222 475 unaffected pregnancies with measurements of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 7-14 weeks gestation. Multiple regression modeling of log-transformed marker values was used to produce log multiples of the median (MoM) values for PAPP-A and free beta-hCG. The models included terms for the center attended and the machine used for biochemical analysis, gestational age, maternal racial origin, maternal weight, smoking status and method of conception. Bivariate Gaussian distributions were fitted to log MoM PAPP-A and log MoM free beta-hCG in trisomy 21 and in unaffected pregnancies. In each case the patient-specific risk for trisomy 21 was estimated by multiplying the ...
https://kclpure.kcl.ac.uk/portal/en/publications/firsttrimester-combined-screening-for-trisomy-21-at-714-weeks-gestation%283a9584aa-420d-45ff-a992-eabed9f953d2%29.html
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Women of childbearing potential must have negative serum beta human chorionic gonadotropin (beta-HCG) pregnancy tests performed within 21 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on weekends, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (beta-HCG) pregnancy test will be performed upon completion of the study ...
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Pregnancy Outcomes in Women with Unexplained Elevation of Maternal Serum Human Chorionic Gonadotropin Levels at Midtrimester.Pregnancy Outcomes in Women with Unexplained Elevation of Maternal Serum Human Chorionic Gonadotropin Levels at Midtrimester.
Our purpose was to determine the association between unexplained elevation of maternal serum human chorionic gonadotropin (hCG) in the second trimester and adverse pregnancy outcomes. MATERIAL AND METHODS: Between February 1995 and July 1999, we evaluated 1566 pregnant women who have underwent second trimester triple marker screening tests (alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin) and delivered at Severance Hospital, Yonsei Medical Center. Multiple pregnancies, abnormal fetal karyotypes, fetal anomalies, and abortions were excluded from the study. One hundred twenty-one women with hCG levels greater than 2.0 multiples of the median (MoM) were included in the study group while 1389 women with hCG levels less than 2.0 MoM served as the control group. Pregnancy outcomes were obtained from the delivery and neonatal records in our institution. Adverse pregnancy outcomes between the two groups were compared using chi-square test and Fishers exact test. RESULTS: Women ...
https://www.ogscience.org/journal/view.php?number=3853
Clinical evaluation of human chorionic gonadotropin levels in men with testicular tumors<...Clinical evaluation of human chorionic gonadotropin levels in men with testicular tumors<...
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https://utsouthwestern.pure.elsevier.com/en/publications/clinical-evaluation-of-human-chorionic-gonadotropin-levels-in-men
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Women of childbearing potential must have negative serum beta human chorionic gonadotropin (beta-HCG) pregnancy tests performed within 14 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on weekends, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (beta-HCG) pregnancy test will be performed upon completion of the study ...
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PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings ...
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Ectopic human chorionic gonadotropin in breast carcinoma<...Ectopic human chorionic gonadotropin in breast carcinoma<...
TY - JOUR. T1 - Ectopic human chorionic gonadotropin in breast carcinoma. AU - Castro, A.. AU - Buschbaum, P.. AU - Nadji, M.. AU - Voigt, W.. AU - Tabei, S.. AU - Morales, A.. PY - 1979/10/1. Y1 - 1979/10/1. N2 - Immunoreactive human chorionic gonadotropin (hCG) was found in 9 of 65 surgically removed malignant breast tumors. Concentrations ranged from 5 to greater than 500 mIU hCG/g tumor. hCG was measured by a β-chain specific radioimmunoassay. In further study of these specimens, an immunoperoxidase staining technique was used to stain for hCG in formalin-fixed sections. The hCG was shown to be localized within the cytoplasm and on the surface of the malignant cells.. AB - Immunoreactive human chorionic gonadotropin (hCG) was found in 9 of 65 surgically removed malignant breast tumors. Concentrations ranged from 5 to greater than 500 mIU hCG/g tumor. hCG was measured by a β-chain specific radioimmunoassay. In further study of these specimens, an immunoperoxidase staining technique was used ...
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Pregnancy-associated plasma protein-A2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos |...Pregnancy-associated plasma protein-A2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos |...
Pregnancy-associated plasma protein-A2 (PAPP-A2, pappalysin-2) is a large metalloproteinase, known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in chordamesoderm, notochord, and lower jaw of zebrafish (Danio rerio) embryos, and that papp-a2 knockdown embryos display broadened axial mesoderm, notochord bends, and severely reduced cranial cartilages. Genetic data link these phenotypes to insulin-like growth factor binding protein-3 (Igfbp-3) and Bmp signaling, and biochemical analysis show specific Igfbp-3 proteolysis by Papp-a2, implicating Papp-a2 in the modulation of Bmp signaling by Igfbp-3 proteolysis. Knockdown of papp-a2 additionally resulted in angiogenesis defects, strikingly similar to previous observations in embryos with mutations in components of the Notch system. Concordantly, we find that Notch signaling is modulated by Papp-a2 in vivo, and, furthermore, that PAPP-A2 is capable of modulating Notch ...
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Human Chorionic Gonadotropin (hCG) during Pregnancy | Womens Health EncyclopediaHuman Chorionic Gonadotropin (hCG) during Pregnancy | Womens Health Encyclopedia
Once human chorionic gonadotropin hormone levels are between 1000 and 2000 U/ml a transvaginal ultrasound can be carried out to show the gestational sac. hCG levels can change and the date of conception may be incorrect. When the hCG levels have reached a minimum of 2000 only then would the information from the ultrasound be considered in making a diagnosis.. To make sure that you receive an accurate diagnosis, lots of hCG tests would be carried out over a period of days. By doing the tests a few days apart any questions about the pregnancy will be answered more accurately. Levels of the hCG hormone levels are not used to provide any dates for pregnancy because the numbers are so varied. The two types of human chorionic gonadotropin testings are:. ...
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Tests involving 2 markers in combination with maternal age - specifically PAPP-A (pregnancy-associated plasma protein A), free beta-hCG (beta-human chorionic gonadotropin) and maternal age - were significantly better than those involving single markers, with and without age. They detected 7 out of 10 Down-affected pregnancies (3 in 10 were missed), and a fixed 5% of all tested women got a false-positive result. The addition of further markers (triple tests) was not shown to be statistically superior; the studies included were small, with limited power to detect a difference. The screening blood tests themselves had no adverse effects for the woman, over and above the risks of a routine blood test ...
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Human chorionic gonadotropin (HCG) - Therapeutic ProteinsHuman chorionic gonadotropin (HCG) - Therapeutic Proteins
Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. HCG is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub- units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH), while the beta sub- units of these hormones differ in amino acid sequence.
https://www.creativebiomart.net/therapeutic-proteins/p/140/human-chorionic-gonadotropin-hcg/
What is HCG hormone (or beta hCG) and How the FDA is missing the ball with the Pregnancy Test | HubPagesWhat is HCG hormone (or beta hCG) and How the FDA is missing the ball with the Pregnancy Test | HubPages
HCG hormone (Aka Human Chorionic gonadotropin) is a hormone produced in pregnancy by the developing placenta. HCG informs the body that a pregnancy has happened and tells it to start secreting hormones to support the pregnancy and stop producing...
https://hubpages.com/health/What-is-HCG-hormone-and-How-the-FDA-is-missing-the-ball-with-the-Pregnancy-Test
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Antibody to Human Chorionic Gonadotropin hCG | Molecular DepotAntibody to Human Chorionic Gonadotropin hCG | Molecular Depot
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HCG is a hormone used in boys (before puberty) to cause the normal dropping of the testicles into the scrotum. It is also used in certain boys to help with normal sexual development. It works by causing the testes to release male sex hormones (e.g., testosterone).
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Comparison of human chorionic gonadotropin (hCG), deslorelin, deslorelin combined with hCG, and histrelin to induce ovulation...Comparison of human chorionic gonadotropin (hCG), deslorelin, deslorelin combined with hCG, and histrelin to induce ovulation...
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Human Chorionic Gonadotropin hCG - All You Need to Know!Human Chorionic Gonadotropin hCG - All You Need to Know!
Human chorionic gonadotropin (medically abbreviated to hCG) is a hormone that is produced by the placenta during pregnancy. It helps to keep the pregnancy going and also has an effect on the development of the baby.
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Human Chorionic Gonadotropin for Pregnant WomenHuman Chorionic Gonadotropin for Pregnant Women
The hCG hormone better known as Human Chorionic Gonadotropin is produced at the time of pregnancy. It is constructed by those cells which form the placenta, nourishes the fertilized egg and then attaches to the uterine wall.
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Overexpression of human chorionic gonadotropin causes multiple...Overexpression of human chorionic gonadotropin causes multiple...
Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice.: Human CG is a pregnancy marker secreted by the placenta
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HCG levelHCG level
The most sensitive, accurate and reliable pregnancy test is a blood test for the presence of beta HCG , often just called beta. The HCG is produced by the embryo, and is the embryos signal to the mother that pregnancy has occurred. Beta HCG levels vary according to the gestational age. In a non-pregnant woman, they are less than 10 mIU/ml. They are typically about 100 mIU/ml 14 days after ovulation (DPO) in a healthy singleton pregnancy.
https://www.drmalpani.com/knowledge-center/articles/hcg
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Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.. Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your childs condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.. For childhood extracranial germ cell tumors, alpha-fetoprotein (AFP) tests and beta-human chorionic gonadotropin (β-hCG) tests are done to see if treatment is working. Continued high levels of AFP or β-hCG may mean the cancer is still growing. For at least 3 years after surgery, follow-up will include regular physical exams, imaging tests, and tumor marker tests.. ...
http://yalecancercenter.org/patient/programs/pediatric/info/info.aspx?id=CDR62857
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Fertility Hormones Archives - Rapid LabsFertility Hormones Archives - Rapid Labs
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Anti hCG (Beta 2 Epitope) Antibody, clone INN-hCG-22 | Bio-RadAnti hCG (Beta 2 Epitope) Antibody, clone INN-hCG-22 | Bio-Rad
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Ashley is a 24 year old woman who started the Dr. Simeons HCG Protocol earlier this year. Her height is 59″ and her starting weight was 230 lbs. She chose to inject the HCG (human chorionic gonadotrophin) intramuscularly daily for six weeks at a time.. After completing six weeks at the beginning of April 2009 she had lost 31 lbs and weighed 199 lbs.. At the end of May 2009 she started another round of HCG treatment and when she followed up in the office today she had lost another 20.2 lbs in 21 days. Today her weight was 178.2 lbs. She plans to complete a full six week round and then take a break for a while.. As Ashley started to lose weight she first lost most of the abnormal fat deposits in her upper body, including her face, chest, arms, and abdomen. Her hips and thighs were not reducing much initially. However, during the last round of treatment she noticed significant reductions in her hips and thighs.. Considerations for future treatment, besides HCG, include MIC injections for general ...
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September 2013 Case of the Month Question | UC Davis Department of PathologySeptember 2013 Case of the Month Question | UC Davis Department of Pathology
The patient is a healthy 80yrs old male with a large, right, painless scrotal swelling that has progressed in size slowly for many years. The following tumor biomarkers were performed and found to be negative: AFP, LDH, betaHCG. Scrotal ultrasound demonstrated a right paratesticular mass without involvement of testis.. ...
http://www.ucdmc.ucdavis.edu/pathology/education/residency_program/caseofthemonth/201309.html
Glycoprotein hormones, alpha polypeptideGlycoprotein hormones, alpha polypeptide
"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". The Journal of Biological ... Bellisario R, Carlsen RB, Bahl OP (Oct 1973). "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit". ... The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), ... cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin". Nature. 281 (5730): 351-6. ...
https://en.wikipedia.org/wiki/Glycoprotein_hormones,_alpha_polypeptide
CGB2 (gene)CGB2 (gene)
"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin ... Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1984). "The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19". Hum. Genet. 67 (2): 174-177 ...
https://en.wikipedia.org/wiki/CGB2_(gene)
Gestational trophoblastic diseaseGestational trophoblastic disease
But GTD also leads to elevated serum hCG (human chorionic gonadotropin hormone). Since pregnancy is by far the most common ... the beta subunit of hCG (beta hCG) is also always elevated. Therefore, if GTD is clinically suspected, serum beta hCG is also ... This tissue may grow at the same rate as a normal pregnancy, and produces chorionic gonadotropin, a hormone which is measured ... Walkington L, Webster J, Hancock BW, Everard J, Coleman RE (May 2011). "Hyperthyroidism and human chorionic gonadotrophin ...
https://en.wikipedia.org/wiki/Gestational_trophoblastic_disease
CGB1CGB1
"The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of ... Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene ... Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin ... 1985). "Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta". Nucleic ...
https://en.wikipedia.org/wiki/CGB1
FSHBFSHB
Follitropin subunit beta also known as follicle-stimulating hormone beta subunit (FSH-B) is a protein that in humans is encoded ... chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a ... of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. ... "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human ...
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CGB5CGB5
... monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene". Molecular Endocrinology. 17 (1): 11-26. ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin ( ... Chorionic gonadotropin, beta polypeptide 5 is a protein that in humans is encoded by the CGB5 gene. ... "No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women". Endocrine. 34 (1-3): 117- ...
https://en.wikipedia.org/wiki/CGB5
ImmunocontraceptionImmunocontraception
... beta-subunit of human chorionic gonadotropin linked to tetanus toxoid". Fertil Steril. 34 (4): 328-35. doi:10.1016/s0015-0282( ... "Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma". Gut. 42 (1): 88-91. doi: ... neuroendocrine tumors exclusively produce human chorionic gonadotropin a-subunit (hCGa)". Hum Pathol. 31 (8): 966-972. doi: ... "A novel human cancer vaccine elicits cellular responses to the tumor-associated antigen, human chorionic gonadotropin b". Clin ...
https://en.wikipedia.org/wiki/Immunocontraception
Luteinizing hormoneLuteinizing hormone
... and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits (labeled alpha- and beta- subunits ... "Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone and human follicle-stimulating hormone on ... This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both ... The beta subunits vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is ...
https://en.wikipedia.org/wiki/Luteinizing_hormone
Pregnancy testPregnancy test
... look for the presence of the beta subunit of human chorionic gonadotropin (hCG) in blood or urine. For a qualitative test the ... The two primary methods are: 1) testing for human pregnancy hormone (human chorionic gonadotropin (hCG)) in blood or urine and ... Lenton, E. A.; Neal, L. M.; Sulaiman, R. (June 1982). "Plasma concentrations of human chorionic gonadotropin from the time of ... Identified in the early 20th century, human chorionic gonadotropin (hCG) is a glycoprotein hormone that rises quickly in the ...
https://en.wikipedia.org/wiki/Pregnancy_test
Ray IlesRay Iles
"Human Chorionic Gonadotropin (hCG) in the Secretome of Cultured Embryos: Hyperglycosylated hCG and hCG-Free Beta Subunit Are ... Cole, Laurence A.; Butler, Stephen A. (17 February 2020). 100 Years of Human Chorionic Gonadotropin: Reviews and New ...
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Thyroid-stimulating hormoneThyroid-stimulating hormone
... the alpha and the beta subunit. The α (alpha) subunit (i.e., chorionic gonadotropin alpha) is nearly identical to that of human ... The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The β chain has a 118-amino ... chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The α subunit is thought to be ... receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse ...
https://en.wikipedia.org/wiki/Thyroid-stimulating_hormone
Follicle-stimulating hormoneFollicle-stimulating hormone
... and human chorionic gonadotropin (hCG). The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist ... while the beta subunits vary. Both subunits are required for biological activity. FSH has a beta subunit of 111 amino acids ( ... "Gonadotropin-releasing hormone regulation of gonadotropin subunit gene expression in female rats: actions on follicle- ... In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3. It is expressed in two cell types, most ...
https://en.wikipedia.org/wiki/Follicle-stimulating_hormone
Human chorionic gonadotropinHuman chorionic gonadotropin
1qfw: TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT ... "Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary". J. Clin. ... "Fusing the carboxy-terminal peptide of the chorionic gonadotropin (CG) beta-subunit to the common alpha-subunit: retention of O ... Human chorionic gonadotropin can be used as a tumor marker,[26] as its β subunit is secreted by some cancers including seminoma ...
https://en.wikipedia.org/wiki/Beta-HCG
List of MeSH codes (D06)List of MeSH codes (D06)
... chorionic gonadotropin MeSH D06.472.699.649.367.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.699.649.367.562 ... chorionic gonadotropin MeSH D06.472.351.326.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.351.326.562 - ... chorionic gonadotropin MeSH D06.472.759.367.125 - chorionic gonadotropin, beta subunit, human MeSH D06.472.759.367.562 - ... beta subunit MeSH D06.472.699.631.525.343.288.625 - follicle stimulating hormone, human MeSH D06.472.699.631.525.343.288.750 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D06)
List of MeSH codes (D23)List of MeSH codes (D23)
... chorionic gonadotropin, beta subunit, human MeSH D23.101.840.375 - hormones, ectopic MeSH D23.101.840.400 - ki-67 antigen MeSH ... human platelet MeSH D23.050.705.230 - blood group antigens MeSH D23.050.705.230.031 - abo blood-group system MeSH D23.050. ... transforming growth factor beta MeSH D23.348.479.996 - wnt proteins MeSH D23.348.479.996.500 - wnt1 protein MeSH D23.348. ... beta carotene MeSH D23.767.261.700 - retinoids MeSH D23.767.261.700.050 - acitretin MeSH D23.767.261.700.250 - etretinate MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
Giant-cell carcinoma of the lungGiant-cell carcinoma of the lung
GCCL have been long known for secretion of the beta subunit of human chorionic gonadotropin (beta-HCG), often in large amounts ... Yaturu S, Harrara E, Nopajaroonsri C, Singal R, Gill S (2003). "Gynecomastia attributable to a human chorionic gonadotropin- ... Dailey JE, Marcuse PM (August 1969). "Gonadotropin secreting giant cell carcinoma of the lung". Cancer. 24 (2): 388-96. doi: ... "A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer ...
https://en.wikipedia.org/wiki/Giant-cell_carcinoma_of_the_lung
Luteinizing hormone beta polypeptideLuteinizing hormone beta polypeptide
Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... 1994). "Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human ... "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit ... In equids the beta subunit polypeptides of luteinizing hormone and chorionic gonadotropin are identical in sequence, differing ...
https://en.wikipedia.org/wiki/Luteinizing_hormone_beta_polypeptide
மனிதக்கரு வெளியுறை கருவகவூக்கி - தமிழ் விக்கிப்பீடியாமனிதக்கரு வெளியுறை கருவகவூக்கி - தமிழ் விக்கிப்பீடியா
"Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary". J. Clin. ... Gregory JJ, Finlay JL (April 1999). "Alpha-fetoprotein and beta-human chorionic gonadotropin: their clinical significance as ... மனிதக்கரு வெளியுறை கருவகவூக்கி (human chorionic gonadotropin; hCG) என்னும் இயக்குநீரானது கருவுற்றபின், சூலுற்ற முட்டையின் ... "New discoveries on the biology and detection of human chorionic gonadotropin". Reprod. Biol. Endocrinol. 7: 8. doi:10.1186/1477 ...
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Chorionic gonadotropin betaChorionic gonadotropin beta
... chorionic gonadotropin". Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin ... Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ... "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492-9. PMID 6194155 ...
https://en.wikipedia.org/wiki/Chorionic_gonadotropin_beta
Human chorionic gonadotropinHuman chorionic gonadotropin
"Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary". J. Clin. ... beta) subunit that is unique to hCG. The α (alpha) subunit is 92 amino acids long. The β-subunit of hCG gonadotropin (beta-hCG ... "Fusing the carboxy-terminal peptide of the chorionic gonadotropin (CG) beta-subunit to the common alpha-subunit: retention of O ... Beta hCG is initially secreted by the syncytiotrophoblast. Human chorionic gonadotropin is a glycoprotein composed of 237 amino ...
https://en.wikipedia.org/wiki/Human_chorionic_gonadotropin
List of MeSH codes (D12.644)List of MeSH codes (D12.644)
... chorionic gonadotropin MeSH D12.644.548.726.367.125 - chorionic gonadotropin, beta subunit, human MeSH D12.644.548.726.367.562 ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 - gtp-binding protein gamma subunits MeSH D12.644.360.375.940 - ... beta subunit MeSH D12.644.548.691.525.343.288.750 - glycoprotein hormones, alpha subunit MeSH D12.644.548.691.525.343.463 - ... alpha subunit MeSH D12.644.548.691.525.883.500 - thyrotropin, beta subunit MeSH D12.644.548.691.692 - pituitary hormones, ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
GonadotropinGonadotropin
... and hence that synthesis of alpha and beta is independently regulated. Another human gonadotropin is human chorionic ... These subunits are heavily modified by glycosylation. The alpha subunit is common to each protein dimer (well conserved within ... the placental/chorionic gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), as well as ... Laurence A. Cole (21 September 2010). Human Chorionic Gonadotropin (hCG). Elsevier. pp. 205-. ISBN 978-0-12-384908-3. Basaria S ...
https://en.wikipedia.org/wiki/Gonadotropin
Beta polipeptid luteinizirajućeg hormonaBeta polipeptid luteinizirajućeg hormona
Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin ... "Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis ... "Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit ... "A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin". Mol. Endocrinol. 6 (6): 951- ...
https://sh.wikipedia.org/wiki/Beta_polipeptid_luteinizirajućeg_hormona
Fertile eunuch syndromeFertile eunuch syndrome
Testicular effects of isolated luteinizing hormone deficiency and reversal by long-term human chorionic gonadotropin treatment ... Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone N Engl J Med. 1992; 326(3): ... Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. N Engl J Med. 2004; 351(25):2619-25. ... full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total ...
https://en.wikipedia.org/wiki/Fertile_eunuch_syndrome
Luteinizing hormone/choriogonadotropin receptorLuteinizing hormone/choriogonadotropin receptor
The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a ... "A receptor-binding region in human choriogonadotropin/lutropin beta subunit". Proceedings of the National Academy of Sciences ... "Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not ... in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin". ...
https://en.wikipedia.org/wiki/Luteinizing_hormone/choriogonadotropin_receptor
Sp4 transcription factorSp4 transcription factor
"Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement ... Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB (July 2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a ... "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin ... "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of ...
https://en.wikipedia.org/wiki/Sp4_transcription_factor
Thyroid-stimulating hormoneThyroid-stimulating hormone
The α (alpha) subunit (i.e., chorionic gonadotropin alpha) is nearly identical to that of human chorionic gonadotropin (hCG), ... SubunitsEdit. TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit. ... The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity.[11] The β chain has a 118- ... receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse ...
https://en.m.wikipedia.org/wiki/Thyroid_stimulating_hormone
LHCGRLHCGR
"A receptor-binding region in human choriogonadotropin/lutropin beta subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 2038-42. ... interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species.". Mol. Endocrinol. 5 (6): 759 ... Amsterdam A, Hanoch T, Dantes A, et al. (2003). "Mechanisms of gonadotropin desensitization.". Mol. Cell. Endocrinol. 187 (1-2 ... Minegishi T, Nakamura K, Takakura Y, et al. (1990). "Cloning and sequencing of human LH/hCG receptor cDNA.". Biochem. Biophys. ...
https://sh.wikipedia.org/wiki/LHCGR
Luteinizirajući hormonLuteinizirajući hormon
"Effects of Human Chorionic Gonadotropin, Human Interstitial Cell Stimulating Hormone and Human Follicle-Stimulating Hormone on ... "Hypogonadism in a Patient with a Mutation in the Luteinizing Hormone Beta-Subunit Gene". New England Journal of Medicine 351 ( ... Ova beta podjedinica sadrži sekvencu aminokiselina koja pokazuje velike homologije sa beta podjedinicama horionski gonadotropin ... Beta podjedinica varira po pomenutim hormonima. LH ima beta podjedinicu od 120 aminokiselina (LHB) koje određuju njegove ...
https://bs.wikipedia.org/wiki/Luteinizirajući_hormon
GonadotropinGonadotropin
... chorionic gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG),[4] as well as at least two ... and a unique beta subunit, which confers biological specificity.[4] The alpha chains are highly conserved proteins of about 100 ... Another human gonadotropin is human chorionic gonadotropin (hCG), produced by the placenta during pregnancy. ... Laurence A. Cole (21 September 2010). Human Chorionic Gonadotropin (hCG). Elsevier. pp. 205-. ISBN 978-0-12-384908-3. .. ...
https://en.m.wikipedia.org/wiki/Gonadotropin
Luteinizing hormoneLuteinizing hormone
... and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits (labeled alpha- and beta- subunits ... "Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone and human follicle-stimulating hormone on ... The beta subunits vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is ... This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both ...
https://en.m.wikipedia.org/wiki/Luteinizing_hormone
Follicle-stimulating hormoneFollicle-stimulating hormone
... and human chorionic gonadotropin (hCG). The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist ... while the beta subunits vary.[2][3] Both subunits are required for biological activity. FSH has a beta subunit of 111 amino ... In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3.[5] It is expressed in two cell types, most ... "Gonadotropin-Releasing Hormone Regulation of Gonadotropin Subunit Gene Expression in Female Rats: Actions on Follicle- ...
https://en.m.wikipedia.org/wiki/Follicle-stimulating_hormone
Index of biochemistry articlesIndex of biochemistry articles
... chorionic gonadotropin - chromatid - chromatin - ciclosporin - Chromatography - Chromosomal crossover - chromosome - chromosome ... beta-2 microglobulin - beta adrenergic receptor - beta sheet - beta-1 adrenergic receptor - beta-2 adrenergic receptor - beta- ... protein subunit - protein synthesis - protein targeting - protein translocation - protein-tyrosine kinase - protein-tyrosine- ... Human Genome Project - hybridization - hydrocarbon - Hydrogen - Hydrogen bond - hydrogenation - hydrogen-deuterium exchange - ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
Nuggehalli Raghuveer MoudgalNuggehalli Raghuveer Moudgal
Follicle-stimulating hormone Human chorionic gonadotropin Bonnet macaque Folliculogenesis India portal Medicine portal His ... "Passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion-a ... He was a member of the task force of the World Health Organization for research in human reproduction for a number of years, ... He was known for his pioneering researches on gonadotropin and was an elected fellow of the Indian Academy of Sciences and the ...
https://en.wikipedia.org/wiki/Nuggehalli_Raghuveer_Moudgal
Amyloid-beta precursor proteinAmyloid-beta precursor protein
"The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and ... gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include presenilin ... "Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic ... The pregnancy hormone human chorionic gonadotropin (hCG) increases AβPP expression and hESC proliferation while progesterone ...
https://en.wikipedia.org/wiki/Amyloid-beta_precursor_protein
CGB3 chorionic gonadotropin subunit beta 3 [Homo sapiens (human)] - Gene - NCBICGB3 chorionic gonadotropin subunit beta 3 [Homo sapiens (human)] - Gene - NCBI
chorionic gonadotropin beta 3 subunit. chorionic gonadotropin beta chain. chorionic gonadotropin beta subunit 3. chorionic ... CGB3 chorionic gonadotropin subunit beta 3 [Homo sapiens] CGB3 chorionic gonadotropin subunit beta 3 [Homo sapiens]. Gene ID: ... CGB3 chorionic gonadotropin subunit beta 3 [ Homo sapiens (human) ] Gene ID: 1082, updated on 7-Jun-2020 ... This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin ( ...
https://www.ncbi.nlm.nih.gov/gene/1082
IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...
Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. ... human chorionic gonadotropin beta subunit; CGB gene expression; CGB1 CGB2; ovarian cancer human chorionic gonadotropin beta ... Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer. Marta Kubiczak 1 ... "Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer." Int. J. Mol. Sci ...
http://www.mdpi.com/1422-0067/14/6/12650
IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...IJMS | Free Full-Text | Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian...
Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. ...
http://www.mdpi.com/1422-0067/14/6/12650/notes
Chorionic gonadotropin, beta subunit, human | definition of Chorionic gonadotropin, beta subunit, human by Medical dictionaryChorionic gonadotropin, beta subunit, human | definition of Chorionic gonadotropin, beta subunit, human by Medical dictionary
What is Chorionic gonadotropin, beta subunit, human? Meaning of Chorionic gonadotropin, beta subunit, human medical term. What ... beta subunit, human in the Medical Dictionary? Chorionic gonadotropin, beta subunit, human explanation free. ... Chorionic gonadotropin, beta subunit, human , definition of Chorionic gonadotropin, beta subunit, human by Medical dictionary ... human chorionic gonadotropin. (redirected from Chorionic gonadotropin, beta subunit, human). Also found in: Dictionary, ...
http://medical-dictionary.thefreedictionary.com/Chorionic+gonadotropin%2C+beta+subunit%2C+human
Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cellsInhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells
The inhibition of beta-hCG sensitizes prostate cancer cells to the antiproliferative effects of c-Myc inhibition, including ... Chorionic Gonadotropin, beta Subunit, Human / antagonists & inhibitors* * Chorionic Gonadotropin, beta Subunit, Human / ... Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells ... Human chorionic gonadotropin, a growth factor implicated in neoplasm, causes activation of c-myc through a G-protein-coupled ...
https://pubmed.ncbi.nlm.nih.gov/12386920/?dopt=Abstract
Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block...Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block...
Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ... Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block ...
https://clincancerres.aacrjournals.org/content/3/12/2355?ijkey=92f2dc5d0dfd68a0ffefe29ada851b873c45bf84&keytype2=tf_ipsecsha
The Sydney eScholarship Repository: The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancerThe Sydney eScholarship Repository: The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancer
The beta-subunit of human chorionic gonadotropin (hCG-β) is elevated in a range of cancers, including high-grade serous cancer ... The role of free beta subunit of human chorionic gonadotropin in high-grade serous cancer. ...
https://ses.library.usyd.edu.au/handle/2123/14706
chorionic gonadotropin subunit beta 5 ELISA Kits from Abnova Corporation | Biocompare.comchorionic gonadotropin subunit beta 5 ELISA Kits from Abnova Corporation | Biocompare.com
Compare chorionic gonadotropin subunit beta 5 ELISA Kits from Abnova Corporation from leading suppliers on Biocompare. View ... chorionic gonadotropin subunit beta 5 ELISA Kits from Abnova Corporation. The ELISA (enzyme-linked immunosorbent assay) is a ... Your search returned 1 chorionic gonadotropin subunit beta 5 ELISA ELISA Kit across 1 supplier. ... chorionic gonadotropin subunit beta 5 ELISA Kits from Abnova Corporation. *Products (1) ...
https://www.biocompare.com/pfu/110627/soids/2-2266693/ELISA_Kit/ELISA_chorionic_gonadotropin_beta_subunit_5?vids=101254
Human Chorionic Gonadotropin, Beta Subunit | MLabsHuman Chorionic Gonadotropin, Beta Subunit | MLabs
Beta Subunit HCG. BHCG. HCG Beta Subunit. HCG, Quantitative. Human Chorionic Gonadotropin, Quantitative. HCG, BETA SUBUNIT. ...
https://mlabs.umich.edu/tests/human-chorionic-gonadotropin-beta-subunit
Human Chorionic Gonadotropin, Beta Subunit, CSF | MLabsHuman Chorionic Gonadotropin, Beta Subunit, CSF | MLabs
CSF levels of HCG are a useful aid in the diagnosis of primary central nervous system (CNS) germ cell tumors (GCTs), as well as an adjunct in the diagnosis of CNS metastases of germ cell tumors (both testicular and choriocarcinoma), and for monitoring recurrence after treatment of these tumors. Elevated levels of HCG in CSF indicate likely presence of one of these types of tumors. Quantitation of HCG in CSF can be important in guiding treatment or monitoring response to treatment.. ...
https://mlabs.umich.edu/tests/human-chorionic-gonadotropin-beta-subunit-csf
hCG (Human Chorionic Gonadotropin) Intact and Beta-Subunit, Quantitative - Meriter LaboratorieshCG (Human Chorionic Gonadotropin) Intact and Beta-Subunit, Quantitative - Meriter Laboratories
Test Code SQ HCGQNT, EPIC LAB143 hCG (Human Chorionic Gonadotropin) Intact and Beta-Subunit, Quantitative Important Note. NEW ...
https://meriter.testcatalog.org/show/SQ-HCGQNT-EPIC-LAB143-1
Beta-subunit HCG | definition of beta-subunit HCG by Medical dictionaryBeta-subunit HCG | definition of beta-subunit HCG by Medical dictionary
... beta-subunit HCG explanation free. What is beta-subunit HCG? Meaning of beta-subunit HCG medical term. What does beta-subunit ... Looking for online definition of beta-subunit HCG in the Medical Dictionary? ... human chorionic gonadotropin. (redirected from beta-subunit HCG). Also found in: Dictionary, Thesaurus, Encyclopedia. ... Human Chorionic Gonadotropin Pregnancy Test, Pregnancy. Patient discussion about human chorionic gonadotropin. Q. Does a slow ...
https://medical-dictionary.thefreedictionary.com/beta-subunit+HCG
Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer | BMC Cancer | Full TextRegulation of human chorionic gonadotropin beta subunit expression in ovarian cancer | BMC Cancer | Full Text
In ovarian cancers increased expression of human chorionic gonadotropin beta subunit is associated with demethylation of CGB ... Expression of human chorionic gonadotropin beta subunit by cancers is extensively documented, yet regulation of the multiple ... From: Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5960-2/figures/3
Use of Hecate-Chorionic Gonadotropin Beta Conjugate in Therapy of Lutenizing Hormone Receptor Expressing Gonadal Somatic Cell...Use of Hecate-Chorionic Gonadotropin Beta Conjugate in Therapy of Lutenizing Hormone Receptor Expressing Gonadal Somatic Cell...
Chorionic Gonadotropin, beta Subunit, Human * Receptors, LH * hecate-chorionic gonadotropin beta-subunit conjugate ... When this peptide is fused with the 81-95 amino acid fragment of chorionic gonadotropin-beta (CGbeta) subunit (hecate-CGbeta), ... Use of Hecate-Chorionic Gonadotropin Beta Conjugate in Therapy of Lutenizing Hormone Receptor Expressing Gonadal Somatic Cell ...
https://pubmed.ncbi.nlm.nih.gov/17363137/?dopt=Abstract
SEER Training:Tumor MarkersSEER Training:Tumor Markers
Beta Subunit HCG (human chorionic gonadotropin). A serum test used as a tumor marker for choriocarcinoma. When the presence of ... Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative ... Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with ... However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients ...
https://training.seer.cancer.gov/cervical-uterine/uterus/abstract-code-stage/extent/markers.html
Literature: Glycoprotein hormone subunit beta (IPR006208) | InterPro | EMBL-EBILiterature: Glycoprotein hormone subunit beta (IPR006208) | InterPro | EMBL-EBI
Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein.. Wu H, ... Crystal structure of human chorionic gonadotropin.. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ ... Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha ... Literature: Glycoprotein hormone subunit beta (IPR006208). References used in this entry. The following publications were ...
http://www.ebi.ac.uk/interpro/entry/IPR006208/literature
Elevated titers of the beta subunit of human chorionic gonadotropin in oophorectomized women being treated for trophoblastic...Elevated titers of the beta subunit of human chorionic gonadotropin in oophorectomized women being treated for trophoblastic...
Hatch, KD, Shingleton, HM, Younger, B & Boots, LR 1980, Elevated titers of the beta subunit of human chorionic gonadotropin in ... N2 - Radioimmunoassay has shown a cross-reaction of the beta subunit of human chorionic gonadotropin (HCG) with high levels of ... AB - Radioimmunoassay has shown a cross-reaction of the beta subunit of human chorionic gonadotropin (HCG) with high levels of ... Fingerprint Dive into the research topics of Elevated titers of the beta subunit of human chorionic gonadotropin in ...
https://arizona.pure.elsevier.com/en/publications/elevated-titers-of-the-beta-subunit-of-human-chorionic-gonadotrop
Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene...Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene...
... regulation of the expression of human chorionic gonadotropin beta subunit genes correlates with methylation of their promoters ... Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene ... During pregnancy, regulation of the expression of human chorionic gonadotropin beta subunit genes correlates with methylation ... During pregnancy, regulation of hCG beta subunit genes expression correlates with both methylation of their promoters and ...
https://www.fertstertdialog.com/posts/9427-methylation-status-of-human-chorionic-gonadotropin-beta-subunit-promoter-and-tfap2a-expression-as-factors-regulating-cgb-gene-expression-in-placenta?channel_id=400-october-2014
Human Chorionic-Gonadotropin Beta-Subunit Is Encoded by at Least Eight Genes Arranged in Tandem and Inverted Pairs - CSHL...Human Chorionic-Gonadotropin Beta-Subunit Is Encoded by at Least Eight Genes Arranged in Tandem and Inverted Pairs - CSHL...
Human Chorionic-Gonadotropin Beta-Subunit Is Encoded by at Least Eight Genes Arranged in Tandem and Inverted Pairs ... Boorstein, W. R., Vamvakopoulos, N. C., Fiddes, J. C. (1982) Human Chorionic-Gonadotropin Beta-Subunit Is Encoded by at Least ...
http://repository.cshl.edu/id/eprint/39084/
Tumor markers facts, information, pictures | Encyclopedia.com articles about Tumor markersTumor markers facts, information, pictures | Encyclopedia.com articles about Tumor markers
Beta-HCG (Beta-human chorionic gonadotropin)- A tumor marker associated with testicular cancer and tumors, such as ... beta and alpha. It is the beta subunit that is increased in womens serum during early pregnancy. It is also the beta subunit ... Human chorionic gonadotropin (hCG) Human chorionic gonadotropin is normally produced by the placenta during pregnancy. There ... Beta-HCG (Beta-human chorionic gonadotropin). -A tumor marker associated with testicular cancer and tumors, such as ...
https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/tumor-markers
Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an AdultMixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult
... and the beta subunit of human chorionic gonadotropin (βHCG) (Figure 4). These results indicated that the majority of the ... and negative for beta subunit of human chorionic gonadotropin (βHCG) ((b): ×100). They are strongly positive for wide-spectrum ...
https://www.hindawi.com/journals/cris/2012/473790/
Novarel (Chorionic Gonadotropin for Injection): Uses, Dosage, Side Effects, Interactions, WarningNovarel (Chorionic Gonadotropin for Injection): Uses, Dosage, Side Effects, Interactions, Warning
Chorionic Gonadotropin for Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, ... is composed of an alpha and a beta subunit. The alpha subunit is essentially identical to the alpha subunits of the human ... Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, ... The beta subunits of these hormones differ in amino acid sequence.. Chorionic Gonadotropin is a water soluble glycoprotein ...
https://www.rxlist.com/novarel-drug.htm
Piezoelectric ceramic sensor and sensor array for detection of molecular makers - Yang, MengsuPiezoelectric ceramic sensor and sensor array for detection of molecular makers - Yang, Mengsu
Beta Subunit of Human Chorionic Gonadotropin (β-HCG): The β-hCG normally is produced by the placenta. Elevated β-hCG levels ... beta subunit of human chorionic gonadotropin; PSA = prostate-specific antigen.. Adopted from: G. L. Perkins, E. D. Slater, G. K ... beta subunit of human chronic gonadotropin (β-hCG); and Prostate-Specific Antigen (PSA). ... The system is composed of multiple subunits in an array format, each subunit containing a different marker detecting component ...
http://www.freepatentsonline.com/y2010/0088039.html
Human chorionic gonadotropin - definition of human chorionic gonadotropin by The Free DictionaryHuman chorionic gonadotropin - definition of human chorionic gonadotropin by The Free Dictionary
human chorionic gonadotropin synonyms, human chorionic gonadotropin pronunciation, human chorionic gonadotropin translation, ... English dictionary definition of human chorionic gonadotropin. n. Abbr. HCG A hormone produced by the placenta that maintains ... The beta sub-unit of the altered hormone carries a piece of the beta subunit from a related placental hormone, human chorionic ... Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile ...
https://www.thefreedictionary.com/human+chorionic+gonadotropin
Testicular Cancer Workup: Approach Considerations, Imaging Studies, ProceduresTesticular Cancer Workup: Approach Considerations, Imaging Studies, Procedures
... and the beta subunit of human chorionic gonadotropin (beta-hCG). ... Human chorionic gonadotropin (hCG) , 5,000 IU/mL (1,000 ng/mL) ... Elevation of serum beta-hCG and AFP levels, alone or in combination, is not sufficiently sensitive or specific to establish the ... However, AFP, beta-hCG, and LDH levels are vital in the evaluation and management of patients with testicular cancers. They are ... Patients with pure seminoma may have elevated levels of beta-hCG but do not have elevated AFP levels. If AFP is elevated in ...
https://emedicine.medscape.com/article/279007-workup
Current Perspectives in Polycystic Ovary Syndrome - American Family PhysicianCurrent Perspectives in Polycystic Ovary Syndrome - American Family Physician
PCOS = polycystic ovary syndrome; β-hCG = beta subunit human chorionic gonadotropin; TSH = thyroid-stimulating hormone; DHEAS ... PCOS = polycystic ovary syndrome; β-hCG = beta subunit human chorionic gonadotropin; TSH = thyroid-stimulating hormone; DHEAS ... Wang CF, Gemzell C. The use of human gonadotropins for the induction of ovulation in women with polycystic ovarian disease. ... Because the human effects of first-trimester use are unknown, discontinuation of therapy at the onset of pregnancy confirmation ...
https://www.aafp.org/afp/2003/0815/p697.html
Chorionic gonadotropin molecule, illustration - Stock Image F019/2289 - Science Photo LibraryChorionic gonadotropin molecule, illustration - Stock Image F019/2289 - Science Photo Library
Cartoon model, coloured per chain (alpha subunit coloured pink, beta subunit blue). - Stock Image F019/2289 ... Human Chorionic Gonadotropin (hCG) glycoprotein hormone, chemical structure. Used in fertility treatments and in vitro ... gonadotropin, gynaecology, gynecology, hcg, health, helical, helix, hormone, human, human chorionic gonadotropin, illustration ... Caption: Human Chorionic Gonadotropin (hCG) glycoprotein hormone, chemical structure. Used in fertility treatments and in vitro ...
http://www.sciencephoto.com/media/870751/view/chorionic-gonadotropin-molecule-illustration
Glycoprotein hormones, alpha polypeptide - WikipediaGlycoprotein hormones, alpha polypeptide - Wikipedia
"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit". The Journal of Biological ... Bellisario R, Carlsen RB, Bahl OP (Oct 1973). "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit". ... The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), ... cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin". Nature. 281 (5730): 351-6. ...
https://en.wikipedia.org/wiki/Glycoprotein_hormones,_alpha_polypeptide
Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy - Full Text View - ClinicalTrials.govEffectiveness Of Expectant Management In The Tubal Ectopic Pregnancy - Full Text View - ClinicalTrials.gov
human chorionic gonadotropin beta subunit. expectant management. Additional relevant MeSH terms: Pregnancy, Ectopic. Pregnancy ... When the decline of beta-hCG titers was , 15% in this interval, the patient was followed with weekly dosing of β-hCG until the ...
https://clinicaltrials.gov/ct2/show/NCT01876004?term=ectopic+pregnancy&rank=7
CDC - References - US SPR - Reproductive HealthCDC - References - US SPR - Reproductive Health
Disappearance of human chorionic gonadotropin and its alpha- and beta-subunits after term pregnancy. Clin Chem 1997;43:2155-63 ... Human chorionic gonadotropin in maternal plasma after induced abortion, spontaneous abortion, and removed ectopic pregnancy. ... Human chorionic gonadotropin tests. Expert Rev Mol Diagn 2009;9:721-47. http://dx. doi. org/10. 1586/erm. 09. 51external icon ... Reyes FI, Winter JS, Faiman C. Postpartum disappearance of chorionic gonadotropin from the maternal and neonatal circulations. ...
https://www.cdc.gov/reproductivehealth/contraception/mmwr/spr/references.html
PregnancyPlacentalSpecificityGonadotrophinFollicle-stimulaHormonesChoriogonadotropinPolypeptideThyroid -stimulGenePlacentaUrineQuantitativeSerumGnRHCorpus luteumFragmentUrinaryTumorsGenesOvarianImmunogenDifferent subunitsReceptorLutropinDescriptorTumorConfersAntigenGlycoprotein composedPMIDBiologicalAlpha-fetoproteinTrimesterChainPeptideIntactQualitativeFree beta-hCGAmino acid
Pregnancy33
  • Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. (nih.gov)
  • Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. (mdpi.com)
  • Testing for the beta fraction of human chorionic gonadotropin is the basis for most serum and urine pregnancy tests. (thefreedictionary.com)
  • During pregnancy, regulation of the expression of human chorionic gonadotropin beta subunit genes correlates with methylation of their promoters and TFAP2A expression. (fertstertdialog.com)
  • Chorionic Gonadotropin is a water soluble glycoprotein derived from human pregnancy urine. (rxlist.com)
  • Induction of ovulation and pregnancy in the anovulatory , infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. (rxlist.com)
  • Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins (See prescribing information for menotropins for dosage and administration for that drug product). (rxlist.com)
  • Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population. (thefreedictionary.com)
  • HCG maintains pregnancy, and its beta sub-unit allows it to stay in the bloodstream longer than FSH. (thefreedictionary.com)
  • Qualitative point-of-care (POC) [2] human chorionic gonadotropin (hCG) testing is routinely performed on urine samples obtained in the Emergency Department (ED) or before surgery to rule out pregnancy and prevent fetal injury or death. (thefreedictionary.com)
  • Adnexal sonographic findings in ectopic pregnancy and their correlation with tubal rupture and human chorionic gonadotropin levels. (thefreedictionary.com)
  • Diagnostic testing company Quidel Corporation (NASDAQ:QDEL) revealed on Monday the receipt of 510(k) clearance from the US Food and Drug Administration (FDA) for its Sofia hCG fluorescent immunoassay (FIA) for use on the Sofia Analyzer for the rapid, objective detection of elevated levels of human chorionic gonadotropin (hCG), an early indicator of pregnancy. (thefreedictionary.com)
  • In the early twentieth century human chorionic gonadotropin (hCG) was identified as the major hormone associated with pregnancy. (quidel.com)
  • All pregnancy tests are based on the beta subunit. (quidel.com)
  • Immunoassay for the qualitative detection of human chorionic gonadotropin (hCG) in serum or urine for the early detection of pregnancy. (quidel.com)
  • Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. (curehunter.com)
  • Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. (bookdepository.com)
  • The beta subunit, on the other hand, is unique to HCG and is thus the part that is tested for in pregnancy test s. (everything2.com)
  • Native purified CGB from human pregnancy urine. (abnova.com)
  • Pregnancy tests detect the presence of human chorionic gonadotropin (hCG) in urine or serum. (encyclopedia.com)
  • The beta subunit is most similar to that of LH and it gives hCG its unique function of maintaining pregnancy by helping the corpus luteum survive as a source of progesterone, until the placenta is established. (news-medical.net)
  • A qualitative serum [beta]-HCG pregnancy test was positive. (thefreelibrary.com)
  • The implications of the slow rise in the [beta]-HCG were discussed, and the patient wished the pregnancy terminated if the physicians believed it was abnormal. (thefreelibrary.com)
  • Two days later, the [beta]-HCG level was 29,000, and a third ultrasound 13 days after the original one demonstrated a viable intrauterine pregnancy corresponding to a fetal age of 8 weeks. (thefreelibrary.com)
  • Human chorionic gonadotropin interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy . (wikipedia.org)
  • For the treatment of prepubertal cryptorchidism (not due to anatomical obstruction), for the treatment of selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males and for the induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. (creativebiomart.net)
  • Given reports of pregnancy-associated lupus flares in humans and the ameliorating influence of hCG in murine models of organ-specific (Th1-mediated) autoimmune disease, the effects of administration of the hormone in animals genetically prone to systemic autoimmunity (a state which, like pregnancy, can also be notionally considered to constitute a Th2 skew, given associated hypergammaglobulinemia and antibody-mediated pathology) are being investigated. (nii.res.in)
  • Alpha subunit and human chorionic gonadotropin in normal pregnancy and gestational trophoblastic disease. (healthtap.com)
  • Hyperglycosylated human chorionic gonadotropin as a predictor of ongoing pregnancy. (harvard.edu)
  • The only time tetanus vaccine has been given in five doses is when it is used as a carrier in fertility regulating vaccines laced with the pregnancy hormone, Human Chorionic Gonadotropin (HCG) developed by WHO in 1992. (globalresearch.ca)
  • Human chorionic gonadotropin (hCG) is used as an endocrine marker of pregnancy. (reproductivemedicine.com)
  • Monitoring hCG-producing tumours (eg, hydatidiform mole, uterine choriocarcinoma, gonadal and extragonadal germ cell tumours): an assay that detects the free β subunit as well as the whole molecule is required and is also suitable for pregnancy-related applications. (edu.au)
  • The bishops' statement notes that in the Philippines, Nicaragua, and Mexico, the tetanus vaccine was "laced with Beta human chorionic gonadotropin (b-HCG) sub unit … to vaccinate women against future pregnancy. (lifesitenews.com)
Placental5
  • To evaluate mechanisms regulating the expression of CGB genes in placental tissues from uncomplicated pregnancies and chorionic samples from spontaneous miscarriages. (fertstertdialog.com)
  • Nine placental samples from term deliveries and 21 chorionic samples from miscarriages at 7-13 weeks of gestation. (fertstertdialog.com)
  • The experiments showed significant differences in CGBs' expression and their regulation between placental and chorionic tissues. (fertstertdialog.com)
  • In placental tissues and chorionic tissues from 7 to 9 weeks of gestation, the expression level of CGBs was shown to be associated with the amount of TFAP2A transcripts. (fertstertdialog.com)
  • Glycoprotein hormones [ ( PUBMED:6267989 ) ( PUBMED:1445230 ) ] (or gonadotropins) are a family of proteins, which include the mammalian hormones follitropin (FSH), lutropin (LSH), thyrotropin (TSH) placental chorionic gonadotropins hCG and eCG [ ( PUBMED:6314263 ) ] and chorionic gonadotropin (CG), as well as at least two forms of fish gonadotropins. (embl.de)
Specificity5
  • Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. (nih.gov)
  • however, their beta chains are unique and confer biological specificity. (wikipedia.org)
  • However, the beta subunit is different in FSH, LH and TSH and are involved in conferring biological specificity. (fishersci.com)
  • The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. (genecards.org)
  • Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN). (curehunter.com)
Gonadotrophin2
  • Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene. (wikipedia.org)
  • [ 5-7 ] Neither of them was secreting the beta subunit of human chorionic gonadotrophin (β-hCG). (medscape.com)
Follicle-stimula9
  • Structure of human follicle-stimulating hormone in complex with its receptor. (ebi.ac.uk)
  • Three-dimensional structure of human follicle-stimulating hormone. (ebi.ac.uk)
  • The alpha subunit is essentially identical to the alpha subunits of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha subunit of human thyroid -stimulating hormone (TSH). (rxlist.com)
  • The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. (wikipedia.org)
  • Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. (wikipedia.org)
  • The alpha subunit is a 92-amino acid sequence that is identical with that of luteinizing hormone ( LH ), follicle stimulating hormone ( FSH ), and thyroid-stimulating hormone ( TSH ). (everything2.com)
  • It is heterodimeric , with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and β (beta) subunit that is unique to hCG. (wikipedia.org)
  • The alpha sub-unit is essentially identical to the alpha sub- units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH), while the beta sub- units of these hormones differ in amino acid sequence. (creativebiomart.net)
  • Follicle-stimulating hormone (FSH) is a heterodimeric glycoprotein formed by the non-covalent binding of subunits alpha and beta. (biomedreports.com)
Hormones15
  • The beta subunits of these hormones differ in amino acid sequence. (rxlist.com)
  • Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene. (wikipedia.org)
  • The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. (wikipedia.org)
  • The alpha subunit is similar to those found on the pituitary hormones FSH, LH ans TSH. (fishersci.com)
  • Primary hypogonadism results from defect in the gonads themselves and it has a high level of the gonadotropin hormones FSH and LH . (wikidoc.org)
  • The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). (genecards.org)
  • This is a glycoprotein with an alpha subunit which is shared by many other hormones, including LH, FSH and TSH. (news-medical.net)
  • Expression and secretion of the mature hormones are regulated by gonadotropin-releasing hormone (GnRH), which is itself secreted from the hypothalamus. (asm.org)
  • The beta subunit of all these hormones differs greatly and is responsible for their respective specific hormone function. (southtees.nhs.uk)
  • HCG exists in a number of biologically active iso-hormones including the intact hormone and the free beta subunit. (southtees.nhs.uk)
  • FSH, luteinizing hormone (LH), thyroid-stimulating hormone (TSH) and human chorionic gonadotropin (HCG) are collectively known as the glycoprotein hormones family. (biomedreports.com)
  • We report a case of a transgender woman whose treatment with female hormones and a gonadotropin-releasing hormone (GnRH) analogue unmasked an occult hCG-secreting seminoma of the testis. (medscape.com)
  • Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology. (embl.de)
  • The primary structures of the glycoprotein hormones follitropin (FSH), lutropin (LH), human choriogonadotropin (hCG) and thyrotropin (TSH) have been determined, hCG has been crystallized and initial diffraction data obtained. (embl.de)
  • The beta subunit of hCG differs from other pituitary glycoprotein hormones, which results in its unique biochemical and immunological properties. (southtees.nhs.uk)
Choriogonadotropin1
  • 1987). "A receptor-binding region in human choriogonadotropin/lutropin beta subunit" . (wikipedia.org)
Polypeptide2
  • Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta subunit. (rxlist.com)
  • HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and Beta subunits. (fishersci.com)
Thyroid -stimul1
  • Gestational transient thyrotoxicosis (GTT) is a condition that is associated with the stimulation of thyroid stimulating hormone (TSH) receptor by human chorionic gonadotropin (hCG) [1]. (alliedacademies.org)
Gene10
  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). (nih.gov)
  • The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. (nih.gov)
  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. (genecards.org)
  • This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. (genecards.org)
  • CGB1 (Chorionic Gonadotropin Subunit Beta 1) is a Protein Coding gene. (genecards.org)
  • Recent studies have identified key factors involved in luteinizing hormone β (LHβ) gonadotropin gene transcription: the nuclear receptor SF-1, the bicoid -related homeoprotein Ptx1 (Pitx1), and the immediate-early Egr-1 gene. (asm.org)
  • In the pituitary of knockout mice, the absence of Egr-1 results in a lack of the gonadotropin luteinizing hormone β (LHβ) gene expression in gonadotrope cells despite the presence of other gonadotrope markers ( 29 , 55 ). (asm.org)
  • Clone HCGb/459 is a mouse monoclonal antibody specific to the human gene, CGB3, or Chorionic gonadotropin subunit beta 3. (biocompare.com)
  • Segregation patterns of polymorphic restriction sites of the gene encoding the alpha subunit of human chorionic gonadotropin in trophoblastic disease. (healthtap.com)
  • Contains a comprehensive listing of all genes from the Human Gene Nomenclature Committee (HGNC) database alongside laboratories and tests available in the country. (edu.au)
Placenta4
  • hCG beta is the beta chain of hCG (Human chorionic gonadotropin), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. (fishersci.com)
  • Human chorionic gonadotropin ( hCG ) is a hormone produced by the placenta after implantation . (wikipedia.org)
  • Naturally, it is produced in the human placenta by the syncytiotrophoblast . (wikipedia.org)
  • Human chorionic gonadotropin (hCG) is also a glycoprotein secreted by the syncytiotrophoblastic cells of the normal placenta. (aacc.org)
Urine5
  • The QuickVue hCG Urine test is a sensitive immunoassay for the qualitative detection of human chorionic gonadotropin (hCG) in urine for the early detection. (quidel.com)
  • In 2006, a comprehensive proteomic study identified more than 1500 proteins from healthy human urine samples, simultaneously reflecting the complexity and the potential information concealed in the urinary proteome ( 8 ). (mcponline.org)
  • Like any other gonadotropins , it can be extracted from the urine of pregnant women or produced from cultures of genetically modified cells using recombinant DNA technology. (wikipedia.org)
  • According to the researcher, the FSH products in China include Urofollitropin (u-FSH) extracted from urine and Recombinant Human Follitropin (rh-FSH). (biomedreports.com)
  • False-Negative Urine Human Chorionic Gonadotropin Testing in the Clinical Laboratory. (harvard.edu)
Quantitative2
  • Ultrasonography and quantitative measurement of the [beta]-subunit of human chorionic gonadatropin ([bega]-HCG) have raised the expectation that early determination of fetal viability is possible. (thefreelibrary.com)
  • is an accurate, rapid, semi- quantitative immunochromatografic test for the determination of the N-terminal fragment of brain-type natriuretic peptide in human serum, plasma and whole blood as an aiding tool for screening. (bushorchimp.com)
Serum7
  • However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated. (cancer.gov)
  • Radioimmunoassay has shown a cross-reaction of the beta subunit of human chorionic gonadotropin (HCG) with high levels of luteinizing hormone (LH) in the serum of four women who underwent bilateral oophorectomy as part of their treatment for trophoblastic disease. (elsevier.com)
  • The most abundant immunoglobulin class in human serum is IgG, which consists of 4 subclasses defined by unique amino acid sequences within the [gamma] heavy chain constant region. (thefreelibrary.com)
  • in whole blood , serum or plasma CE certified Applications: The CrP Rapid Test Dipstick (Whole Blood /Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of human CrP in whole blood , serum or. (bushorchimp.com)
  • Aetna considers multiple serum marker testing (dimeric inhibin A, human chorionic gonadotropin (hCG) with maternal serum alpha-fetoprotein (MSAFP), and unconjugated estriol) medically necessary for pregnant women who have been adequately counseled and who desire information on their risk of having a Down syndrome fetus. (aetna.com)
  • Levels of human chorionic gonadotropin (hCG), maternal serum alpha-fetoprotein (MSAFP), and unconjugated estriol have been associated with maternal risk of Down syndrome, a chromosomal abnormality associated with mental retardation, congenital heart defects, and physical anomalies. (aetna.com)
  • Testing revealed an elevated serum level of the beta subunit of human chorionic gonadotropin (β-hCG), diagnostic of an hCG-secreting testicular seminoma, as the underlying cause of unexpected T production. (medscape.com)
GnRH3
  • Functional hypothalamic amenorrhea (FHA) is a disorder of the hypothalamic-pituitary-ovarian axis in an otherwise anatomically and organically normal system and is characterized by a suppression of the gonadotropin-releasing hormone (GnRH) pulsatility. (healio.com)
  • GnRH stimulation of gonadotropin expression and secretion occurs through the G-protein-linked phospholipase C/inositol triphosphate intracellular signaling pathway, which ultimately leads to protein kinase C (PKC) activation and increased intracellular calcium levels. (asm.org)
  • Transcription factors mediating the effects of GnRH-induced signals on transcription of gonadotropin genes have not yet been identified. (asm.org)
Corpus luteum1
  • Absence of corpus luteum rescue by chorionic gonadotropin in women immunized with a contraceptive vaccine. (nii.res.in)
Fragment5
  • When this peptide is fused with the 81-95 amino acid fragment of chorionic gonadotropin-beta (CGbeta) subunit (hecate-CGbeta), it targets cells expressing luteinizing hormone receptor (LHR), even at very low doses, or when LHR is expressed at low level. (nih.gov)
  • Point-of-care and over-the-counter qualitative human chorionic gonadotropin (hCG) devices remain susceptible to false-negative results caused by excess hCG [beta] core fragment. (thefreedictionary.com)
  • The ″In-tact″ hormone, ″nicked″ forms of HCG, the beta-core fragment and the free beta sub-unit. (southtees.nhs.uk)
  • 2. A vaccine according to claim 1 characterized in that the hormone, fragment or peptide is the beta subunit of human chorionic gonadotropin, a fragment thereof or a peptide substantially immunologically equivalent thereto. (epo.org)
  • 3. A vaccine according to claim 1 characterized in that the fragment or peptide has a sequence corresponding to amino acids 109-145 of the beta subunit of human chorionic gonadotropin, or a sequence substantially immunologically equivalent thereto. (epo.org)
Urinary2
  • This is the first study of human urinary glycoproteins where "intact" glycopeptides were studied, i.e. the presence of glycans and their attachment sites were proven without doubt. (mcponline.org)
  • Urinary beta-core. (aetna.com)
Tumors2
  • Immunohistochemical study of the expression of human chorionic gonadotropin-β in salivary gland tumors. (nih.gov)
  • The inhibition of beta-hCG sensitizes prostate cancer cells to the antiproliferative effects of c-Myc inhibition, including tumors that are refractory to c-Myc decrease alone. (nih.gov)
Genes3
  • Unresponsiveness to c-myc inhibition in DU145 cells was overcome by targeting both beta-hCG and c-myc genes, resulting in potentiation of the antiproliferative effect seen with inhibition of beta-hCG alone. (nih.gov)
  • and trivia ("All eight of the genes for the beta-subunit of human chorionic gonadotropin are located on which of the following chromosomes? (thefreedictionary.com)
  • The β-subunit of hCG gonadotropin ( beta-hCG ) contains 145 amino acids, encoded by six highly homologous genes that are arranged in tandem and inverted pairs on chromosome 19q 13.3 - CGB ( 1 , 2 , 3 , 5 , 7 , 8 ). (wikipedia.org)
Ovarian6
  • The mRNA levels of Ubc9 were confirmed in human ovarian cell lines before and after transfection with pEGFP-N1-Ubc9 or small interfering RNA (siRNA) targeted Ubc9 by real-time polymerase chain reaction (PCR). (mdpi.com)
  • A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer. (amedeo.com)
  • Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis. (amedeo.com)
  • Harmine suppresses the proliferation and migration of human ovarian cancer cells through inhibiting ERK/CREB pathway. (amedeo.com)
  • Human chorionic gonadotropin beta regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer. (amedeo.com)
  • Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. (amedeo.com)
Immunogen2
  • Effects of a beta-human chorionic gonadotropin subunit immunogen administered in aqueous solution with a novel nonionic block copolymer adjuvant in patients with advanced cancer. (aacrjournals.org)
  • The PA1-27113 immunogen is beta chain of human chorionic gonadotropin. (fishersci.com)
Different subunits1
  • The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. (embl.de)
Receptor1
  • Epidermal growth factor receptor expression in human lung cancer cell lines. (atcc.org)
Lutropin2
  • Human pituitary lutropin. (wikipedia.org)
  • In China's end markets of ART and sex hormone drugs, macromolecular bioengineered drugs such as Recombinant Human Follitropin, Recombinant Follitropin beta, Recombinant Human Chorionic Gonadotropin, and Recombinant Human Lutropin alfa are taking the place of small-molecule chemicals. (biomedreports.com)
Descriptor1
  • Chorionic Gonadotropin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Tumor4
  • B Subunit of Human Chorionic Gonadotropin Promotes Tumor Invasion and Predicts Poor Prognosis of Early-Stage Colorectal Cancer. (nih.gov)
  • Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. (cancer.gov)
  • These info advise that human chorionic gonadotropin beta subunit might possibly act as being a tumor development-stimulating problem which suggests that ahead of a single rushes into subsequent this HCG diet plan, it really is finest to learn further about it. (selfgrowth.com)
  • Discordant induction of tumor-associated antigen, TA-4 and chorionic gonadotropin beta in cultured cervical carcinoma cells. (healthtap.com)
Confers1
  • The alpha subunit is common to all members of the glycoprotein-hormone family and the beta subunit is unique to hCG and confers its biological activity. (quidel.com)
Antigen1
  • 1 year, maintains a normal XY karyotype, and expresses the cell surface markers (alkaline phosphatase, stage-specific embryonic antigen 3, stage-specific embryonic antigen 4, TRA-1-60, and TRA-1-81) that are characteristic of human embryonal carcinoma cells. (pnas.org)
Glycoprotein composed2
  • hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. (genecards.org)
  • Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa , approximately 14.5 αhCG and 22.2kDa βhCG. (wikipedia.org)
PMID1
  • The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). (genecards.org)
Biological1
  • They share the same alpha subunit but differ from each other in beta subunit which determines their biological activity. (biomedreports.com)
Alpha-fetoprotein1
  • R278.5 cells allowed to differentiate in vitro secrete bioactive chorionic gonadotropin into the medium, express chorionic gonadotropin alpha- and beta-subunit mRNAs, and express alpha-fetoprotein mRNA, indicating trophoblast and endoderm differentiation. (pnas.org)
Trimester1
  • These may include a diagnostic test such as chorionic villus sampling (CVS) in the first trimester or amniocentesis in the second trimester. (labcorp.com)
Chain3
  • Also called: ß-HCG, beta-HCG, beta chain H-CG. (cancer.gov)
  • Cartoon model, coloured per chain (alpha subunit coloured pink, beta subunit blue). (sciencephoto.com)
  • Beta chain of human chorionic gonadotropin. (fishersci.com)
Peptide3
  • The clinical and immunological effects of a vaccine consisting of CTP37, a synthetic peptide corresponding to the COOH-terminal peptide (CTP) of beta-human chorionic gonadotropin (beta-hCG) conjugated to diphtheria toxoid, combined with CRL 1005, a novel synthetic nonionic block copolymer adjuvant, were examined. (aacrjournals.org)
  • beta-hCG is mostly similar to beta-LH, with the exception of a Carboxy Terminus Peptide (beta-CTP) containing four glycosylated serine residues that is responsible for hCG's longer half-life. (wikipedia.org)
  • Absence of the COOH-terminal peptide on ectopic human chorionic gonadotropin beta-subunit (hCG beta). (healthtap.com)
Intact1
  • The intact molecule and free beta) while others measure the intact OR free beta. (southtees.nhs.uk)
Qualitative2
  • Qualitative point-of-care human chorionic Gonadotropin testing: can we defuse this ticking time bomb? (thefreedictionary.com)
  • Blood (FOB) Rapid Test Cassette FOB TEST INTENDED USE The One-Step Fecal Occult Blood (FOB) Diagnostic Kit is a qualitative detection of human occult blood in feces forself- testing . (bushorchimp.com)
Free beta-hCG1
  • free beta subunit of human chorionic gonadotropin (free beta-hCG) and beta-2 Microglobulin (B2MG). (mtbeurope.info)
Amino acid2
  • The amino acid sequence of human chorionic gonadotropin. (wikipedia.org)
  • The alpha subunit has a similar amino acid sequence to that of LH, FSH and TSH. (southtees.nhs.uk)
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