AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
ChoriocarcinomaChoriocarcinoma, Non-gestationalUterine NeoplasmsHydatidiform MoleTrophoblastic NeoplasmsTrophoblastsHydatidiform Mole, InvasiveGestational Trophoblastic DiseaseChorionic Gonadotropin, beta Subunit, HumanChorionic GonadotropinPlacentaPregnancyChorionic VilliGlycoprotein Hormones, alpha SubunitTumor Cells, CulturedTesticular NeoplasmsTranscutaneous Electric Nerve StimulationXerostomiaElectric Stimulation TherapySalivationPain ManagementSalivaPilocarpine
Choriocarcinoma
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Choriocarcinoma, Non-gestational
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.
Uterine Neoplasms
Tumors or cancer of the UTERUS.
Hydatidiform Mole
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Trophoblastic Neoplasms
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Trophoblasts
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Hydatidiform Mole, Invasive
A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
Gestational Trophoblastic Disease
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
Chorionic Gonadotropin, beta Subunit, Human
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
Chorionic Gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Placenta
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Chorionic Villi
The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).
Glycoprotein Hormones, alpha Subunit
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Tumor Cells, Cultured
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Testicular Neoplasms
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Transcutaneous Electric Nerve Stimulation
The use of specifically placed small electrodes to deliver electrical impulses across the SKIN to relieve PAIN. It is used less frequently to produce ANESTHESIA.
Xerostomia
Decreased salivary flow.
Electric Stimulation Therapy
Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.
Salivation
The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.
Pain Management
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Saliva
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Pilocarpine
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

Postmenopausal choriocarcinoma: a case report. (1/10)

Postmenopausal uterine choriocarcinoma is very rare and benefits of curative chemotherapy. We present here the case of 62-year-old women with uterine bleeding. Emergency surgery revealed a uterine tumor and histopathology findings were consistent with choriocarcinoma. Immunohistochemistry tests confirmed betahCG and cytokeratin expression by malignant cells, thus establishing the positive diagnosis.  (+info)

Primary non-gestational uterine cervical choriocarcinoma with metaplastic transformation from squamous cells. (2/10)

BACKGROUND: Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking. CASE: Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- and immunohistochemically-confirmed, non-gestational cervical choriocarcinoma could be diagnosed in which there was metaplastic transformation from squamous cells . The patient underwent 5 courses of an actinomycin-D chemotherapeutic regimen and radical hysterectomy with bilateral pelvic lymphadenectomy. CONCLUSION: Primary non-gestational uterine cervical choriocarcinoma may indeed arise from metaplastic transformation of epithelial tissue.  (+info)

Male choriocarcinoma with metastasis to the jejunum: a case report and review of the literature. (3/10)

We report on a patient with male choriocarcinoma. The patient was a 31-year-old male patient with jejunal choriocarcinoma that metastasized from the mediastinum. He was admitted complaining of melena and severe anemia. Upper and lower gastrointestinal endosocopy was performed, but no source of bleeding was seen. Chest X-ray and CT revealed a mediastinal tumor 7 cm in size anterior to the arotic arch. Superior mesenteric arteriography showed irregularities and macular opacity in the jejunal artery. An emergency laparatomy was performed because of massive gastrointestinal bleeding. A jejunal tumor approximately 4 cm in size was resected and numerous metastases were observed in the liver and mesentery. Histopathological examination showed metastatic jejunal choriocarcinoma. Gynecomastia was not present and the testes were normal. Serum beta-human chorionic gonadotropin (HCG) was at an abnormally high level of 4,396 ng/mL. Because of metastases to the brain and invasion to the trachea, he died on postoperative day 20. We report this rare case of a male patient with metastases of choriocarcinoma to the gastrointestinal tract from the mediastinum, together with a review of the literature.  (+info)

Primary intracranial choriocarcinoma: MR imaging findings. (4/10)

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Papillary cystadenofibroma of epididymis: a case report. (5/10)

We present the first reported case of papillary cystadenofibroma of the epididymis. The tumor occurred in a 46-year-old man. The mass was 3.7 cm and included a hemorrhagic fluid-filled cyst. Microscopically, stromal-filled papillae were lined by low cuboidal to columnar epithelium. Epithelial cells were reactive for cytokeratin 7, cytokeratins AE1/3, and focally in the apical cytoplasm for CD10. Focal CD10 reactivity was also noted in the stroma. The lesion was negative for alpha-fetoprotein. These findings ruled out other lesions, including metastatic renal cell carcinoma.  (+info)

Pathological complete response and two-year disease-free survival in a primary gastric choriocarcinoma patient with advanced liver metastases treated with germ cell tumor-based chemotherapy: a case report. (6/10)

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Pure nongestational choriocarcinoma of the ovary: a case report. (7/10)

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma. (8/10)

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Choriocarcinoma in a 73-year-old woman: a case report and review of the literature | Journal of Medical Case Reports | Full TextChoriocarcinoma in a 73-year-old woman: a case report and review of the literature | Journal of Medical Case Reports | Full Text
Choriocarcinomas can be divided into two types: gestational and non-gestational. Gestational choriocarcinomas mostly occur in woman of reproductive age, usually within one year following a molar or non-molar pregnancy. Non-gestational choriocarcinomas can arise from germ cell or trophoblastic differentiation within endometrial carcinomas. Extraovarian germ cell tumors, including choriocarcinomas may arise from germ cells that failed to complete their migration to the gonads [8]. However, germ cell choriocarcinomas arising from the female genital tract in postmenopausal woman with normal ovaries on CT scan and sonography are extremely rare [3, 9].. When choriocarcinoma occurs in postmenopausal woman, it is difficult to rule out the possibility of trophoblastic differentiation within an endometrial carcinoma. Choriocarcinoma has been reported in association with endometrial carcinoma as well as liver, lung and urinary bladder carcinomas [10]. These types of choriocarcinomas can be diagnosed based ...
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-4-379
BLASE (bladder): Topics by WorldWideScience.orgBLASE (bladder): Topics by WorldWideScience.org
Ossification of the bladder wall, detected radiographically as a nonhomogeneous radiopaque area in the cranioventral part of the bladder in a puppy, is reported. We speculate that chronic inflammation due to the presence of uroliths in the lumen may have stimulated a metaplastic transformation of th... DRIVER (German) ...
https://worldwidescience.org/topicpages/multi/DE/b/bladder.html
Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal...Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal...
TY - JOUR. T1 - Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal neuroendocrine neoplasms. AU - Grover, Amelia C.. AU - Libutti, Steven K.. AU - Pingpank, James F.. AU - Helsabeck, Cynthia. AU - Beresnev, Tatiana. AU - Alexander, H. Richard. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2004/12. Y1 - 2004/12. N2 - We report results of using isolated hepatic perfusion (IHP) in patients with advanced progressive liver metastases (LM) from pancreatic and gastrointestinal neuroendocrine neoplasms (NENs). Thirteen patients with LM from NENs (mean percent hepatic replacement, 30; range, 10-60) were treated with a 1-hour hyperthermic IHP via a laparotomy with the use of 1.5 or 2.0 mg/kg melphalan and/or 1 mg tumor necrosis factor. An oxygenated extracorporeal circuit with inflow through the gastroduodenal artery and common hepatic artery, and outflow to a segment of the inferior vena cava was used. ...
https://einstein.pure.elsevier.com/en/publications/isolated-hepatic-perfusion-for-the-treatment-of-patients-with-adv-2
Primary nongestational choriocarcinoma of the ovary. | Postgraduate Medical JournalPrimary nongestational choriocarcinoma of the ovary. | Postgraduate Medical Journal
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
http://pmj.bmj.com/content/61/718/757
Choriocarcinoma in a female infant]<...
TY - JOUR. T1 - [Choriocarcinoma in a female infant]. AU - SCHULER, D.. AU - JUHASZ, J.. PY - 1960/1/3. Y1 - 1960/1/3. KW - CHORIOCARCINOMA/in infancy and childhood. KW - GENITALIA, FEMALE/neoplasms. UR - http://www.scopus.com/inward/record.url?scp=84925556201&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84925556201&partnerID=8YFLogxK. M3 - Article. C2 - 14443737. AN - SCOPUS:84925556201. VL - 101. SP - 29. EP - 30. JO - Orvosi Hetilap. JF - Orvosi Hetilap. SN - 0030-6002. ER - ...
https://hungary.pure.elsevier.com/en/publications/choriocarcinoma-in-a-female-infant-2
Chemotherapy of choriocarcinoma (1 course): Costs for treatment #197511 in Germany | BookingHealthChemotherapy of choriocarcinoma (1 course): Costs for treatment #197511 in Germany | BookingHealth
Chemotherapy of choriocarcinoma (1 course) (costs for program #197511) ✔ University Hospital Rechts der Isar of the Munich Technical University ✔ Department of Pediatrics ✔ BookingHealth.com
https://bookinghealth.com/klinikum-rechts-der-isar-der-tu-m-nchen/treatment-programs/197511-chemotherapy-of-choriocarcinoma-1-course.html
Diagnosis of choriocarcinoma: Costs for treatment #201259 in Germany | BookingHealthDiagnosis of choriocarcinoma: Costs for treatment #201259 in Germany | BookingHealth
Diagnosis of choriocarcinoma (costs for program #201259) ✔ Academic Hospital Harlaching ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
https://bookinghealth.com/harlaching-clinic/diagnostic-programs/201259-diagnosis-of-choriocarcinoma.html
Article - Infantile choriocarcinoma with cutaneous, liver, and lung metastasesArticle - Infantile choriocarcinoma with cutaneous, liver, and lung metastases
CASE SUMMARY An otherwise healthy 37-day-old male presented to dermatology with a pedunculated, friable red glabellar mass (centered between the eyes). First...
https://appliedradiology.com/articles/infantile-choriocarcinoma-with-cutaneous-liver-and-lung-metastases
metaplastic carcinoma [Lymphedema People]metaplastic carcinoma [Lymphedema People]
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Nov 2011 Choi BB, Shu KS. Source Department of Radiology. Correspondence to: Bo Bae Choi. Email: [email protected] Abstract BACKGROUND Metaplastic carcinomas are ductal carcinomas that display metaplastic transformation of the glandular epithelium to non-glandular mesenchymal tissue. Metaplastic carcinoma has a poorer prognosis than most other breast cancers, so the differential diagnosis is important. Although many clinical and pathologic findings have been reported, to our knowledge, few imaging findings related to metaplastic carcinoma have been reported.PurposeTo investigate whole-breast imaging findings, including mammography, sonography, MRI, and pathologic findings, including immunohistochemical studies of metaplastic carcinomas of the breast. MATERIAL AND METHODS: We analyzed 33 cases of metaplastic carcinoma between January 2001 and January 2011. Mammography, ultrasonography, and MRI were recorded ...
http://t.lymphedemapeople.com/wiki/doku.php?id=metaplastic_carcinoma
Choriocarcinoma in Females - Causes, Symptoms, Diagnosis, Treatment, PreventionChoriocarcinoma in Females - Causes, Symptoms, Diagnosis, Treatment, Prevention
Choriocarcinoma is a rare uterine cancer following pregnancy. The tumor arises in the trophoblast cells lining the embryo. Vaginal bleeding is a common symptom.
https://www.medindia.net/patients/patientinfo/choriocarcinoma-in-females.htm
SearchSearch
Search Results | JNCCNSearch Results | JNCCN
Esophageal adenocarcinoma (EAC) is an often deadly cancer with a rising incidence in Western countries. Chronic gastroesophageal reflux disease is associated with the metaplastic transformation of normal squamous epithelium to premalignant specialized intestinal metaplasia within the esophagus (Barretts esophagus). Barretts esophagus may progress to low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even EAC. Although nondysplastic Barretts esophagus progresses to EAC at a rate of 0.5% per year, rates of progression for true LGD and HGD are significantly higher. Treatment is mandatory for HGD and may be appropriate in select patients with nondysplastic Barretts esophagus and many with LGD. Thus, accurate pathologic assessment is necessary before considering endoscopic therapy. Previously, only esophagectomy was offered to patients with HGD or EAC. However, esophagectomy has significant morbidity and mortality, and therefore endoscopic therapies have been advocated for early Barretts ...
https://jnccn.org/search?access=user&f_0=author&pageSize=10&q_0=Rajesh+N.+Keswani&sort=relevance
A Rare Cause of Massive Hemoptysis: Bilateral Endobronchial Lesions Secondary to Metastatic Gestational Choriocarcinoma in a...A Rare Cause of Massive Hemoptysis: Bilateral Endobronchial Lesions Secondary to Metastatic Gestational Choriocarcinoma in a...
Choriocarcinoma usually affects premenopausal women. A postmenopausal choriocarcinoma is a rare event and there are few cases reported in the literature. In our case, the tumor clinically was manifested 20 years after the last pregnancy. The biological mechanism behind the long latent period for the gestational choriocarcinoma to develop in a postmenopausal woman has not been described. The gestational choriocarcinoma arises within the uterine cavity, however our case was presented with pulmonary metastatic involvement without evidence of uterine disease (i.e. spontaneous regression of the primary tumor). This behavior is known as the burn-out phenomenon. It has been described mainly in melanoma, as well as in other tumors including the germ cell tumors. A molecular immunological mechanism seems to be involved in this process. The tumor growth and spread cause repetitive exposures of the T-lymphocytes to the primary tumor antigens. The T-cells tend to eliminate the primary lesion, while the ...
http://medcraveonline.com/ICPJL/ICPJL-02-00058.php
Cancers | Free Full-Text | Epigenetic Therapy in Human ChoriocarcinomaCancers | Free Full-Text | Epigenetic Therapy in Human Choriocarcinoma
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
http://www.mdpi.com/2072-6694/2/3/1683
Gambling - Page 3 - Centro CanarioGambling - Page 3 - Centro Canario
Casinos online give you the ability to play real-money and free games and knowing you would like to go ahead with the real money slots online, you need to place the deposit. Coronavirus has caused several land-based outlets over the world to close down. Just the online slots have stayed up and offered all the…. ...
https://centrocanario.org/category/gambling/page/3
Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature | International...Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature | International...
Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. In our case, a 43-year-old woman was admitted in our hospital because she had amenorrhea for 2 months and elevated serum beta-human chorionic gonadotropin levels. The patient was considered to have an ectopic pregnancy. Initially, she was treated with methotrexate, but since there was a continuous rise in human chorionic gonadotropin levels, the patient underwent a laparoscopy, along with dilatation and curettage (D&C) of the uterine cavity. Histopathologic findings, including immunohistochemical study, led to the diagnosis of choriocarcinoma of the cervix. Finally, the patient underwent a transabdominal hysterectomy and received single agent chemotherapy with methotrexate. Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as ...
https://ijgc.bmj.com/content/17/4/921
A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an...A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an...
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, whole genome sequencing (WGS) and methylation analysis of the tumour and surrounding mature placenta. The results of the WGS sequencing indicated a very low level of mutation and the absence of any driver mutations or oncogene activity in the tumour. The methylation analysis identified a distinctly different profile in the tumour from that of the mature placenta. Comparison with a panel of reference methylation profiles from different stages of placental development indicated that the tumour segregated with the first trimester samples. These findings suggest
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5906-8/email/correspondent/c1/new
An unusual case of primary pulmonary choriocarcinoma with brain metastasis in a HIV positive patientAn unusual case of primary pulmonary choriocarcinoma with brain metastasis in a HIV positive patient
Primary pulmonary choriocarcinoma (PPC) is a rare entity with propensity to rapid metastasis and associated poor outcomes. Pleural effusion has been rarely associated with PPC. We report a case of a 23 year old nulliparous female HIV positive who present with chest pains, dry cough and pleural effusions, with leukocytosis. Poor response to antibiotics prompted further evaluation which revealed PPC with fatal metastasis. Diagnosis of PPC was reached by raised levels of beta HCG, histology and immunohistochemistry. Combination chemotherapy with radiotherapy gave some hope; - however patient demised, mostly likely due to lung metastasis. This case left doctors wondering; - what if, the diagnosis was reached earlier ...
http://ubrisa.ub.bw/handle/10311/1294
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone HCGb/54 ]...HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone HCGb/54 ]...
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone HCGb/54 ] validated in IHC-P (AH10393-100), Abgent
http://www.abgent.com/products/AH10393-HCG-beta-Pregnancy-Choriocarcinoma-Marker-Antibody-Without-BSA-and-Azide
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide - Mouse Monoclonal Antibody [Clone SPM529 ] IHC-P ...HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide - Mouse Monoclonal Antibody [Clone SPM529 ] IHC-P ...
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM529 ] validated in IHC-P (AH10397-20), Abgent
http://www.abgent.com/products/AH10397-HCG-beta-Pregnancy-Choriocarcinoma-Marker-Antibody-With-BSA-and-Azide
Cystadenofibroma | Colorado PROFILES
Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS ...
https://profiles.ucdenver.edu/display/21257932
SEER Training:Tumor MarkersSEER Training:Tumor Markers
A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
https://training.seer.cancer.gov/cervical-uterine/uterus/abstract-code-stage/extent/markers.html
Gestational choriocarcinoma - WikipediaGestational choriocarcinoma - Wikipedia
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, it happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst) Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus. Chemotherapy is the treatment of choice. In certain cases, a hysterectomy and radiation are ...
https://en.wikipedia.org/wiki/Gestational_choriocarcinoma
Trophoblastic Neoplasms | Profiles RNS
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691 ...
https://profiles.umassmed.edu/display/108652
Severe lower gastrointestinal bleeding due to metastatic choriocarcinoma to the jejunum: A rare presentation. | AbstractSevere lower gastrointestinal bleeding due to metastatic choriocarcinoma to the jejunum: A rare presentation. | Abstract
We report a 33-year-old woman with intermittent abdominal pain and lower gastrointestinal bleeding. Upper and lower GI endoscopy did not reveal any le..
http://www.alliedacademies.org/abstract/severe-lower-gastrointestinal-bleeding-due-to-metastatic-choriocarcinoma-to-the-jejunum-a-rare-presentation-7221.html
Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells: Differential utilization of...
TY - JOUR. T1 - Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells. T2 - Differential utilization of cis-regulatory elements. AU - Kingsley-Kallesen, Michelle. AU - Johnson, Lance. AU - Scholtz, Beáta. AU - Kelly, David. AU - Rizzino, Angie. PY - 1997/4. Y1 - 1997/4. N2 - Previous studies have shown that the transcription of the TGF-β2 gene is controlled by at least one negative and two positive regulatory regions in differentiated cells derived from both embryonal carcinoma cells and embryonic stem cells. The use of TGF-β2 promoter/reporter gene constructs has also identified a CRE/ATF motif near the TATA box that appears to heavily influence the transcription of the TGF-β2 gene. In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. We demonstrated that both similarities and differences exist ...
https://hungary.pure.elsevier.com/en/publications/transcriptional-regulation-of-the-tgf-%CE%B22-gene-in-choriocarcinoma-
Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells<...Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells<...
TY - JOUR. T1 - Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells. AU - Dutta-Roy, Asim K. AU - Taylor, J AU - Gordon, Margaret Jane. AU - Hoggard, Nigel. AU - Campbell, Fiona Margaret. PY - 2002/12/6. Y1 - 2002/12/6. N2 - Arachidonic acid at 100 nM stimulated internalisation of I-125-leptin in human placental choriocarcinoma (BeWo) cells by Mold compared with controls. In contrast, eicosapentaenoic acid at similar concentration decreased internalisation of leptin by 2-fold. Use of ibuprofen and indomethacin (inhibitors of prostaglandin synthesis) inhibited the stimulatory effect of arachidonic acid. Prostaglandin E-2, a cyclooxygenase metabolite of arachidonic acid, stimulated internalisation of leptin by these cells. All these data demonstrate that stimulation of leptin internalisation by arachidonic acid in placental trophoblasts may be mediated via prostaglandin E2. (C) 2002 Elsevier Science (USA). All rights reserved.. AB - Arachidonic ...
https://abdn.pure.elsevier.com/en/publications/arachidonic-acid-stimulates-internalisation-of-leptin-by-human-pl
Ovarian serous cystadenofibroma | Radiology Case | Radiopaedia.orgOvarian serous cystadenofibroma | Radiology Case | Radiopaedia.org
Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...
https://radiopaedia.org/cases/ovarian-serous-cystadenofibroma?lang=us
Choriocarcinoma Symptoms, Treatment, Prognosis « CancerWORLD Cancer Treatment Research JournalChoriocarcinoma Symptoms, Treatment, Prognosis « CancerWORLD Cancer Treatment Research Journal
Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a womans uterus (womb). It is a. CancerWORLD Cancer Treatment Research Journal
http://cancerworld.info/choriocarcinoma-symptoms-treatment-prognosis/
Metastatic choriocarcinoma to the breast: Mammography and color doppler ultrasound<...Metastatic choriocarcinoma to the breast: Mammography and color doppler ultrasound<...
TY - CHAP. T1 - Metastatic choriocarcinoma to the breast. T2 - Mammography and color doppler ultrasound. AU - Kalra, Naveen. AU - Ojili, Vijaynadh. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2008. Y1 - 2008. N2 - This chapter presents the role of mammography and color Doppler ultrasound in the diagnosis of metastatic choriocarcinoma to the breast. The most common mammographic appearance of metastases is of one or more well-circumscribed masses located in the upper and outer quadrant of the breast. Typically, there is no spiculation, architectural distortion, skin thickening, or other signs of surrounding desmoplastic reaction, which characterize the majority of primary breast carcinomas. However, the mammographic findings of breast metastases can be variable and range from normal to a pattern of diffuse skin thickening that simulates inflammatory carcinoma. The mammographic appearances of metastatic hematologic malignancies can vary from discrete to ill-defined ...
https://scholars.uthscsa.edu/en/publications/metastatic-choriocarcinoma-to-the-breast-mammography-and-color-do
Plus itPlus it
Background: Activated phosphatidylinositol 3-kinase (PI3K) and its downstream serine/threonine protein kinase B (PKB)/AKT are important regulators of cell proliferation, apoptosis and invasion. The activation at Ser473 residue of PKB by phosphorylation (p-PKB Ser473) is required for its maximal activity. Dysregulation of PI3K/PKB signaling pathway has been found to be an important feature of many human malignancies. However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression of p-PKB (Ser473) in gestational trophoblastic disease and the effects of inhibiting PI3K/PKB signaling pathway in choriocarcinoma. Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser473) expression was detected by Western Blot. The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by ...
http://cancerres.aacrjournals.org/content/69/9_Supplement/4106
November 3, 2014 - Case Comprehensive Cancer Center - Case Western Reserve UniversityNovember 3, 2014 - Case Comprehensive Cancer Center - Case Western Reserve University
The symposium had two tracks, including a psychosocial track focused on information for patients, survivors and caregivers that delved into the psychosocial complexities of the AYA oncology population. The scientific track covered specific advances in targeted tumor-based therapy. Lectures by Dr. John Perentesis, Professor and Oncology Division Director at Cincinnati Childrens Hospital, and by Deborah Morosini, Vice President of Clinical Development at Foundation Medicine, highlighted advances in pharmacogenomics and how they are beginning to inform treatment modalities and clinical trials objectives for cancers common to AYA patients.. Lectures by Dr. Brandon Hayes-Latin, Director of the AYA Cancer Program at OHSU, and by Dr. Lindsay Frazier of the Dana Farber Cancer Institute shed light on how reorganization of the NCI infrastructure supporting the clinical trials process is enhancing collaborations between the Childrens Oncology Group and those cooperative groups developing clinical trials ...
http://case.edu/cancer/about/director/2014archive/november-3-2014/

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