Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).Choriocarcinoma, Non-gestational: A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.Uterine Neoplasms: Tumors or cancer of the UTERUS.Hydatidiform Mole: Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.Trophoblastic Neoplasms: Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Hydatidiform Mole, Invasive: A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.Gestational Trophoblastic Disease: A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.Chorionic Gonadotropin, beta Subunit, Human: The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Chorionic Villi: The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).Glycoprotein Hormones, alpha Subunit: The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Pregnancy Tests: Tests to determine whether or not an individual is pregnant.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)Iodine Compounds: Inorganic compounds that contain iodine as an integral part of the molecule.Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Seminoma: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Dysgerminoma: A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)Public Health: Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.Cryptorchidism: A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.Hemoptysis: Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.Bronchial DiseasesBronchoscopy: Endoscopic examination, therapy or surgery of the bronchi.Polyglutamic Acid: A peptide that is a homopolymer of glutamic acid.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Folic Acid Antagonists: Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)Tetrahydrofolate Dehydrogenase: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.Professional Role: The expected function of a member of a particular profession.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Spondylolisthesis: Forward displacement of a superior vertebral body over the vertebral body below.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Obstetrics: A medical-surgical specialty concerned with management and care of women during pregnancy, parturition, and the puerperium.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Mobile Applications: Computer programs or software installed on mobile electronic devices which support a wide range of functions and uses which include television, telephone, video, music, word processing, and Internet service.Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.Computers, Handheld: A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.Obstetrics and Gynecology Department, Hospital: Hospital department responsible for the administration and management of services provided for obstetric and gynecologic patients.Repetition Priming: A type of procedural memory manifested as a change in the ability to identify an item as a result of a previous encounter with the item or stimuli.

Postmenopausal choriocarcinoma: a case report. (1/10)

Postmenopausal uterine choriocarcinoma is very rare and benefits of curative chemotherapy. We present here the case of 62-year-old women with uterine bleeding. Emergency surgery revealed a uterine tumor and histopathology findings were consistent with choriocarcinoma. Immunohistochemistry tests confirmed betahCG and cytokeratin expression by malignant cells, thus establishing the positive diagnosis.  (+info)

Primary non-gestational uterine cervical choriocarcinoma with metaplastic transformation from squamous cells. (2/10)

BACKGROUND: Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking. CASE: Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- and immunohistochemically-confirmed, non-gestational cervical choriocarcinoma could be diagnosed in which there was metaplastic transformation from squamous cells . The patient underwent 5 courses of an actinomycin-D chemotherapeutic regimen and radical hysterectomy with bilateral pelvic lymphadenectomy. CONCLUSION: Primary non-gestational uterine cervical choriocarcinoma may indeed arise from metaplastic transformation of epithelial tissue.  (+info)

Male choriocarcinoma with metastasis to the jejunum: a case report and review of the literature. (3/10)

We report on a patient with male choriocarcinoma. The patient was a 31-year-old male patient with jejunal choriocarcinoma that metastasized from the mediastinum. He was admitted complaining of melena and severe anemia. Upper and lower gastrointestinal endosocopy was performed, but no source of bleeding was seen. Chest X-ray and CT revealed a mediastinal tumor 7 cm in size anterior to the arotic arch. Superior mesenteric arteriography showed irregularities and macular opacity in the jejunal artery. An emergency laparatomy was performed because of massive gastrointestinal bleeding. A jejunal tumor approximately 4 cm in size was resected and numerous metastases were observed in the liver and mesentery. Histopathological examination showed metastatic jejunal choriocarcinoma. Gynecomastia was not present and the testes were normal. Serum beta-human chorionic gonadotropin (HCG) was at an abnormally high level of 4,396 ng/mL. Because of metastases to the brain and invasion to the trachea, he died on postoperative day 20. We report this rare case of a male patient with metastases of choriocarcinoma to the gastrointestinal tract from the mediastinum, together with a review of the literature.  (+info)

Primary intracranial choriocarcinoma: MR imaging findings. (4/10)

 (+info)

Papillary cystadenofibroma of epididymis: a case report. (5/10)

We present the first reported case of papillary cystadenofibroma of the epididymis. The tumor occurred in a 46-year-old man. The mass was 3.7 cm and included a hemorrhagic fluid-filled cyst. Microscopically, stromal-filled papillae were lined by low cuboidal to columnar epithelium. Epithelial cells were reactive for cytokeratin 7, cytokeratins AE1/3, and focally in the apical cytoplasm for CD10. Focal CD10 reactivity was also noted in the stroma. The lesion was negative for alpha-fetoprotein. These findings ruled out other lesions, including metastatic renal cell carcinoma.  (+info)

Pathological complete response and two-year disease-free survival in a primary gastric choriocarcinoma patient with advanced liver metastases treated with germ cell tumor-based chemotherapy: a case report. (6/10)

 (+info)

Pure nongestational choriocarcinoma of the ovary: a case report. (7/10)

 (+info)

Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma. (8/10)

 (+info)

Choriocarcinomas can be divided into two types: gestational and non-gestational. Gestational choriocarcinomas mostly occur in woman of reproductive age, usually within one year following a molar or non-molar pregnancy. Non-gestational choriocarcinomas can arise from germ cell or trophoblastic differentiation within endometrial carcinomas. Extraovarian germ cell tumors, including choriocarcinomas may arise from germ cells that failed to complete their migration to the gonads [8]. However, germ cell choriocarcinomas arising from the female genital tract in postmenopausal woman with normal ovaries on CT scan and sonography are extremely rare [3, 9].. When choriocarcinoma occurs in postmenopausal woman, it is difficult to rule out the possibility of trophoblastic differentiation within an endometrial carcinoma. Choriocarcinoma has been reported in association with endometrial carcinoma as well as liver, lung and urinary bladder carcinomas [10]. These types of choriocarcinomas can be diagnosed based ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Chemotherapy of choriocarcinoma (1 course) (costs for program #197511) ✔ University Hospital Rechts der Isar of the Munich Technical University ✔ Department of Pediatrics ✔ BookingHealth.com
Diagnosis of choriocarcinoma (costs for program #201259) ✔ Academic Hospital Harlaching ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
CASE SUMMARY An otherwise healthy 37-day-old male presented to dermatology with a pedunculated, friable red glabellar mass (centered between the eyes). First...
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Nov 2011 Choi BB, Shu KS. Source Department of Radiology. Correspondence to: Bo Bae Choi. Email: [email protected] Abstract BACKGROUND Metaplastic carcinomas are ductal carcinomas that display metaplastic transformation of the glandular epithelium to non-glandular mesenchymal tissue. Metaplastic carcinoma has a poorer prognosis than most other breast cancers, so the differential diagnosis is important. Although many clinical and pathologic findings have been reported, to our knowledge, few imaging findings related to metaplastic carcinoma have been reported.PurposeTo investigate whole-breast imaging findings, including mammography, sonography, MRI, and pathologic findings, including immunohistochemical studies of metaplastic carcinomas of the breast. MATERIAL AND METHODS: We analyzed 33 cases of metaplastic carcinoma between January 2001 and January 2011. Mammography, ultrasonography, and MRI were recorded ...
Esophageal adenocarcinoma (EAC) is an often deadly cancer with a rising incidence in Western countries. Chronic gastroesophageal reflux disease is associated with the metaplastic transformation of normal squamous epithelium to premalignant specialized intestinal metaplasia within the esophagus (Barretts esophagus). Barretts esophagus may progress to low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even EAC. Although nondysplastic Barretts esophagus progresses to EAC at a rate of 0.5% per year, rates of progression for true LGD and HGD are significantly higher. Treatment is mandatory for HGD and may be appropriate in select patients with nondysplastic Barretts esophagus and many with LGD. Thus, accurate pathologic assessment is necessary before considering endoscopic therapy. Previously, only esophagectomy was offered to patients with HGD or EAC. However, esophagectomy has significant morbidity and mortality, and therefore endoscopic therapies have been advocated for early Barretts ...
Choriocarcinoma usually affects premenopausal women. A postmenopausal choriocarcinoma is a rare event and there are few cases reported in the literature. In our case, the tumor clinically was manifested 20 years after the last pregnancy. The biological mechanism behind the long latent period for the gestational choriocarcinoma to develop in a postmenopausal woman has not been described. The gestational choriocarcinoma arises within the uterine cavity, however our case was presented with pulmonary metastatic involvement without evidence of uterine disease (i.e. spontaneous regression of the primary tumor). This behavior is known as the "burn-out" phenomenon. It has been described mainly in melanoma, as well as in other tumors including the germ cell tumors. A molecular immunological mechanism seems to be involved in this process. The tumor growth and spread cause repetitive exposures of the T-lymphocytes to the primary tumor antigens. The T-cells tend to eliminate the primary lesion, while the ...
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, whole genome sequencing (WGS) and methylation analysis of the tumour and surrounding mature placenta. The results of the WGS sequencing indicated a very low level of mutation and the absence of any driver mutations or oncogene activity in the tumour. The methylation analysis identified a distinctly different profile in the tumour from that of the mature placenta. Comparison with a panel of reference methylation profiles from different stages of placental development indicated that the tumour segregated with the first trimester samples. These findings suggest
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone HCGb/54 ] validated in IHC-P (AH10393-100), Abgent
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM529 ] validated in IHC-P (AH10397-20), Abgent
A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, it happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst) Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus. Chemotherapy is the treatment of choice. In certain cases, a hysterectomy and radiation are ...
We report a 33-year-old woman with intermittent abdominal pain and lower gastrointestinal bleeding. Upper and lower GI endoscopy did not reveal any le..
TY - JOUR. T1 - Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells. T2 - Differential utilization of cis-regulatory elements. AU - Kingsley-Kallesen, Michelle. AU - Johnson, Lance. AU - Scholtz, Beáta. AU - Kelly, David. AU - Rizzino, Angie. PY - 1997/4. Y1 - 1997/4. N2 - Previous studies have shown that the transcription of the TGF-β2 gene is controlled by at least one negative and two positive regulatory regions in differentiated cells derived from both embryonal carcinoma cells and embryonic stem cells. The use of TGF-β2 promoter/reporter gene constructs has also identified a CRE/ATF motif near the TATA box that appears to heavily influence the transcription of the TGF-β2 gene. In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. We demonstrated that both similarities and differences exist ...
Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...
Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a womans uterus (womb). It is a. CancerWORLD Cancer Treatment Research Journal
Background: Activated phosphatidylinositol 3-kinase (PI3K) and its downstream serine/threonine protein kinase B (PKB)/AKT are important regulators of cell proliferation, apoptosis and invasion. The activation at Ser473 residue of PKB by phosphorylation (p-PKB Ser473) is required for its maximal activity. Dysregulation of PI3K/PKB signaling pathway has been found to be an important feature of many human malignancies. However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression of p-PKB (Ser473) in gestational trophoblastic disease and the effects of inhibiting PI3K/PKB signaling pathway in choriocarcinoma. Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser473) expression was detected by Western Blot. The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by ...
The symposium had two tracks, including a psychosocial track focused on information for patients, survivors and caregivers that delved into the psychosocial complexities of the AYA oncology population. The scientific track covered specific advances in targeted tumor-based therapy. Lectures by Dr. John Perentesis, Professor and Oncology Division Director at Cincinnati Childrens Hospital, and by Deborah Morosini, Vice President of Clinical Development at Foundation Medicine, highlighted advances in pharmacogenomics and how they are beginning to inform treatment modalities and clinical trials objectives for cancers common to AYA patients.. Lectures by Dr. Brandon Hayes-Latin, Director of the AYA Cancer Program at OHSU, and by Dr. Lindsay Frazier of the Dana Farber Cancer Institute shed light on how reorganization of the NCI infrastructure supporting the clinical trials process is enhancing collaborations between the Childrens Oncology Group and those cooperative groups developing clinical trials ...
Examples include: choriocarcinoma hydatidiform mole Gestational trophoblastic disease. ...
... ic hematoma Gestational trophoblastic disease, any abnormal proliferation of the trophoblasts, including choriocarcinoma ...
"A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature ...
The best known of these is the Gestational Trophoblastic Disease (see Choriocarcinoma and Hydatidiform mole), detected by ...
... gestational trophoblastic diseases (GTD), and gestational trophoblastic neoplasms.[medical citation needed] Pregnancy tests may ... These include choriocarcinoma and other germ cell tumors, IgA deficiencies, heterophile antibodies, enterocystoplasties, ... With obstetric ultrasonography the gestational sac sometimes can be visualized as early as four and a half weeks of gestation ( ...
Certain malignancies can mimic the effects of clomifene on the ovaries, also due to increased HCG, in particular gestational ... Ovarian hyperstimulation occurs more often with invasive moles and choriocarcinoma than complete molar pregnancies. A widely ...
... of women who developed choriocarcinoma died within a year. Today, with chemotherapy, choriocarcinoma can be cured in almost ... Li, Min C. (15 September 1979). "The historical background of successful chemotherapy for advanced gestational trophoblastic ... Yarris, Jonathan P; Hunter, Alan J (1 May 2003). "Roy Hertz, M.D. (1909-2002): The cure of choriocarcinoma and its impact on ... Within four months she was "normal without evidence of disease." Li treated two additional patients with choriocarcinoma that ...
Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease ... Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ...
Gestational trophoblastic disease like hydatidiform moles ("molar pregnancy") or choriocarcinoma may produce high levels of ... choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with elements of choriocarcinoma, and islet cell tumor. For this ... A study of 32 normal pregnancies came to the result a gestational sac of 1-3 mm was detected at a mean hCG level of 1150 IU/l ( ... These can be done to diagnose and monitor germ cell tumors and gestational trophoblastic diseases. ...
... of all gestational trophoblastic proliferations. Preceding conditions include molar pregnancy (5%). Compared to choriocarcinoma ... Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to arise from intermediate ...
... on Chromosome 14 that are highly expressed in gestational choriocarcinoma. The EFS mRNA was also identified as differentially ...
... choriocarcinoma MeSH C04.557.470.200.025.455.750 --- choriocarcinoma, non-gestational MeSH C04.557.470.200.025.455.875 --- ... choriocarcinoma MeSH C04.557.465.955.207.750 --- choriocarcinoma, non-gestational MeSH C04.557.465.955.207.875 --- ... gestational trophoblastic neoplasms MeSH C04.850.908.416.186 --- choriocarcinoma MeSH C04.850.908.416.186.875 --- trophoblastic ... choriocarcinoma MeSH C04.557.465.955.416.202.875 --- trophoblastic tumor, placental site MeSH C04.557.465.955.416.812 --- ...
... gestational trophoblastic neoplasms MeSH C13.703.720.949.416.218 --- choriocarcinoma MeSH C13.703.720.949.416.218.875 --- ...
Since gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), ... Stage I choriocarcinoma Stage 2 choriocarcinoma Stage 3 choriocarcinoma Stage 4 choriocarcinoma "choriocarcinoma" at Dorland's ... The cure rate, even for metastatic gestational choriocarcinoma, is around 90-95%. At present,[when?] treatment with single- ... Elements of choriocarcinoma in a mixed testicular tumor have no prognostic importance. Choriocarcinomas can also occur in the ...
... is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long ... "Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ...
"Prognosis of gestational choriocarcinoma at Khyber Teaching Hospital Peshawar". J Ayub Med Coll Abbottabad. 15 (2): 45-8. PMID ... Gestational trophoblastic disease (GTD) may also be called gestational trophoblastic tumour (GTT). Hydatidiform mole (one type ... "Gestational Trophoblastic Disease". Gestational Trophoblastic Disease Lipata F, Parkash V, Talmor M, et al. (April 2010). " ... Lurain JR (January 2011). "Gestational trophoblastic disease II: classification and management of gestational trophoblastic ...
Choriocarcinoma. *Gestational trophoblastic disease. General. *Uterine sarcoma. *Mixed Müllerian tumor. Vagina. *Squamous-cell ...
Trophoblastic neoplasm: Gestational trophoblastic disease *Hydatidiform mole. *Choriocarcinoma. *Placental site trophoblastic ...
This transfer of antibodies begins as early as the 20th week of gestational age, and certainly by the 24th week. This passive ... They are decreased with toxemia, choriocarcinoma, and Placental insufficiency. The placenta and fetus may be regarded as a ...
A molar pregnancy is a gestational trophoblastic disease which grows into a mass in the uterus that has swollen chorionic villi ... risk of developing into choriocarcinoma in Western countries and 10 - 15% in Eastern countries and overall, also a 15% chance ...
While there is no sharp limit of development, gestational age, or weight at which a human fetus automatically becomes viable, a ... Objects such as hydatidiform moles, choriocarcinomas, and blighted ovums are clearly not. Neither will every normal zygote ... gestational age, or whether the placenta and umbilical cord are still attached. This law makes no comment on personhood in ...
... gestational trophoblastic disease - gestational trophoblastic neoplasia - gestational trophoblastic tumor - GI14721 - giant ... choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic leukemia - chronic idiopathic myelofibrosis - chronic ...
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long ... "Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ...
Choriocarcinoma FIGO Stage I Gestational Trophoblastic Tumor FIGO Stage II Gestational Trophoblastic Tumor FIGO Stage III ... Patients with non-gestational choriocarcinoma. *Patients who have previously been treated with cytotoxic chemotherapy; however ... Choriocarcinoma. Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Hydatidiform Mole. Neoplasms, Germ Cell and ... Genetic and Rare Diseases Information Center resources: Gestational Trophoblastic Tumor Choriocarcinoma Hydatidiform Mole ...
Two types of choriocarcinoma have been described: gestational and non-gestational. Usually, gestational choriocarcinoma occurs ... There was no history of gestational trophoblastic disease. Figure 2: Pulmonary metastatic gestational choriocarcinoma. * H&E ... Gestational and non-gestational choriocarcinoma are clinically and pathologically indistinguishable. The only reliable ... It confirmed a gestational type of metastatic choriocarcinoma (Figure 2B). She was started on chemotherapy. EMA/CO (etoposide, ...
Gestational trophoblastic disease (GTD) is a broad term encompassing both benign and malignant growths arising from products of ... ETT is an extremely rare gestational trophoblastic tumor.[5,6] Although originally termed atypical choriocarcinoma, it appears ... Choriocarcinoma, PSTT, and ETT are often grouped under the heading gestational trophoblastic tumors. ... Choriocarcinoma Choriocarcinoma is a malignant tumor of the trophoblastic epithelium. Uterine muscle and blood vessels are ...
Treatments for gestational trophoblastic disease include surgery, chemotherapy and radiation. Learn about treatment plans and ... Gestational trophoblastic neoplasia (GTN) includes invasive moles and gestational choriocarcinoma. They are almost always ... Treatments for gestational trophoblastic disease. If you have gestational trophoblastic disease (GTD), your healthcare team ... Gestational trophoblastic neoplasia (GTN) - blood HCG levels are usually taken every week until the results are normal for at ...
"Prognosis of gestational choriocarcinoma at Khyber Teaching Hospital Peshawar". J Ayub Med Coll Abbottabad. 15 (2): 45-8. PMID ... Gestational trophoblastic disease (GTD) may also be called gestational trophoblastic tumour (GTT). Hydatidiform mole (one type ... "Gestational Trophoblastic Disease". Gestational Trophoblastic Disease Lipata F, Parkash V, Talmor M, et al. (April 2010). " ... Lurain JR (January 2011). "Gestational trophoblastic disease II: classification and management of gestational trophoblastic ...
Examples include: choriocarcinoma hydatidiform mole Gestational trophoblastic disease. ...
In gestational trophoblastic disease (GTD), a tumor develops inside the uterus from tissue that forms after conception (the ... Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus ... Treatment of low-risk gestational trophoblastic neoplasia (GTN) (invasive mole or choriocarcinoma) may include the following:. ... Recurrent or Resistant Gestational Trophoblastic Neoplasia Treatment of recurrent or resistant gestational trophoblastic tumor ...
Neoplastic transformation of trophoblast leads to gestational trophoblastic diseases (GTD). Choriocarcinoma (CCA) and ... Uncorrected OCR) Abstract of thesis entitled GENE EXPRESSION PROFILE IN HUMAN TROPHOBLAST AND GESTATIONAL TROPHOBLASTIC DISEASE ... Gene expression profile in human trophoblast and gestational trophoblastic disease. by Feng, Huichen ...
Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site ... N2 - Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental ... AB - Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental ... abstract = "Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, ...
... increase the risk of persistent gestational trophoblastic disease (GTD) and choriocarcinoma, a malignant, rapidly-growing, and ...
The effect of progesterone on MMP-2 expression in the JAR human choriocarcinoma cell line was analyzed by gelatin zymography. ... gestational trophoblastic neoplasia and preterm labor [11, 12]. The activity of MMP-2 is regulated at multiple levels, ... Human choriocarcinoma cell line (JAR) was obtained from the American Type Culture Collection (Manassas, VA). Cells were ... The effect of progesterone on MMP-2 expression in JAR human choriocarcinoma cell line was conducted. JAR cells (2 × 105) were ...
They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that ... Hydatidiform mole is part of a group of diseases classified as gestational trophoblastic disease, which results from an ... The diagnosis of gestational trophoblastic disease in early pregnancy: implications for screening, counseling and management. ... Molar pregnancy is part of a group of diseases classified as Gestational Trophoblastic Disease (GTD), which originate in the ...
A molar pregnancy is a gestational trophoblastic disease which grows into a mass in the uterus that has swollen chorionic villi ... risk of developing into choriocarcinoma in Western countries and 10 - 15% in Eastern countries and overall, also a 15% chance ...
Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J ... Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: a new basis for gestational Down ... purified from choriocarcinoma patient urine (16)] were calibrated by mass based on amino acid analysis. For 3 years, our all- ... relationship to hCG concentration and gestational age. Fertil Steril 1987;47:584-589. ...
Abstract Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including ... XH3WM1 Choriocarcinoma combined with other germ cell elements XH0774 Malignant teratoma, trophoblastic XH8PK7 Choriocarcinoma, ... Abstract Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of ... Abstract Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles ...
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY ... Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational ... Non-gestational Choriocarcinoma (Choriocarcinoma, Non gestational). Subscribe to New Research on Non-gestational ... 01/01/1986 - "Eight choriocarcinoma cell lines (Two SCH and IMa, were established from non-gestational choriocarcinoma and the ...
Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational, is related to choriocarcinoma of ovary and ... MalaCards integrated aliases for Non-Gestational Choriocarcinoma:. Name: Non-Gestational Choriocarcinoma 12 15 17 ... MalaCards organs/tissues related to Non-Gestational Choriocarcinoma:. 42 Ovary, Cervix, Lung, Small Intestine ... MGI Mouse Phenotypes related to Non-Gestational Choriocarcinoma:. 47 #. Description. MGI Source Accession. Score. Top ...
These findings suggest that gestational choriocarcinoma is likely to arise as a result of aberrations of methylation during ... The results support the hypothesis that gestational choriocarcinoma arises from a normally transient early trophoblast cell. At ... Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for ... In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, ...
Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and primary non-gestational choriocarcinoma of ... MalaCards integrated aliases for Non-Gestational Ovarian Choriocarcinoma:. Name: Non-Gestational Ovarian Choriocarcinoma 12 15 ... MalaCards organs/tissues related to Non-Gestational Ovarian Choriocarcinoma:. 42 Ovary, Brain, Pituitary, Cervix, B Cells ... Articles related to Non-Gestational Ovarian Choriocarcinoma:. #. Title. Authors. Year. 1. Clinical and ultrasound features of ...
Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a womans uterus ... Choriocarcinoma. Choriocarcinoma is a malignant form of gestational trophoblastic disease (GTD). It is much more likely than ... You might hear GTDs called gestational trophoblastic disease, gestational trophoblastic tumors, or gestational trophoblastic ... Half of all gestational choriocarcinomas start off as molar pregnancies. About one-quarter develop in women who have a ...
Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Gestational trophoblastic disease treatment (PDQ) - health professional version. www.cancer.gov/cancertopics/pdq/treatment/ ... Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy. ... Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ...
If you or your loved one has been diagnosed with gestational trophoblastic disease, Memorial Sloan Kettering is ready to help. ... Choriocarcinoma. A choriocarcinoma is even rarer than a hydatidiform mole. This type of GTD may have begun as a hydatidiform ... A choriocarcinoma can also spread more widely to other parts of the body such as the lungs, liver, and/or brain. ... Gestational trophoblastic disease (GTD) is a group of rare tumors that begin during a pregnancy. These tumors start in the ...
Genomic profile in gestational and non-gestational choriocarcinomas.. Mello JB1, Ramos Cirilo PD2, Michelin OC3, Custódio ... Gestational (GC) (derived from the placenta) and non-gestational (NGC) choriocarcinomas are trophoblastic diseases originated ... Array comparative genomic hybridization; Copy number alteration; Gestational choriocarcinoma; Microsatellites; Non-gestational ... All choriocarcinomas were evaluated by copy number alterations using array CGH.. RESULTS: Eight cases were classified as GC and ...
Choriocarcinoma. *Choriocarcinoma is a malignant tumor of the trophoblastic epithelium.[17]. *Cytotrophoblastic cells, ... Smith, Harriet O.; Kohorn, Ernest; Cole, Laurence A. (2005). "Choriocarcinoma and Gestational Trophoblastic Disease". ... Choriocarcinoma can invade the uterine tissue and vasculature and spread to distant sites such as lungs, brain, liver, pelvis, ... Choriocarcinoma. *Bulky, destructive mass with hemorrhage and necrosis[37][38]. *Can be associated with deep myometrial ...
  • They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that has a potential to locally invade the uterus and metastasize. (ommegaonline.org)
  • Gestational trophoblasts are of particular interest to cell biologists because, like cancer, these cells invade tissue (the uterus), but unlike cancer, they sometimes "know" when to stop. (wikipedia.org)
more