A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.
Tumors or cancer of the UTERUS.
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Tests to determine whether or not an individual is pregnant.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
Inorganic compounds that contain iodine as an integral part of the molecule.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
Endoscopic examination, therapy or surgery of the bronchi.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
A peptide that is a homopolymer of glutamic acid.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
The expected function of a member of a particular profession.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Postmenopausal choriocarcinoma: a case report. (1/10)

Postmenopausal uterine choriocarcinoma is very rare and benefits of curative chemotherapy. We present here the case of 62-year-old women with uterine bleeding. Emergency surgery revealed a uterine tumor and histopathology findings were consistent with choriocarcinoma. Immunohistochemistry tests confirmed betahCG and cytokeratin expression by malignant cells, thus establishing the positive diagnosis.  (+info)

Primary non-gestational uterine cervical choriocarcinoma with metaplastic transformation from squamous cells. (2/10)

BACKGROUND: Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking. CASE: Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- and immunohistochemically-confirmed, non-gestational cervical choriocarcinoma could be diagnosed in which there was metaplastic transformation from squamous cells . The patient underwent 5 courses of an actinomycin-D chemotherapeutic regimen and radical hysterectomy with bilateral pelvic lymphadenectomy. CONCLUSION: Primary non-gestational uterine cervical choriocarcinoma may indeed arise from metaplastic transformation of epithelial tissue.  (+info)

Male choriocarcinoma with metastasis to the jejunum: a case report and review of the literature. (3/10)

We report on a patient with male choriocarcinoma. The patient was a 31-year-old male patient with jejunal choriocarcinoma that metastasized from the mediastinum. He was admitted complaining of melena and severe anemia. Upper and lower gastrointestinal endosocopy was performed, but no source of bleeding was seen. Chest X-ray and CT revealed a mediastinal tumor 7 cm in size anterior to the arotic arch. Superior mesenteric arteriography showed irregularities and macular opacity in the jejunal artery. An emergency laparatomy was performed because of massive gastrointestinal bleeding. A jejunal tumor approximately 4 cm in size was resected and numerous metastases were observed in the liver and mesentery. Histopathological examination showed metastatic jejunal choriocarcinoma. Gynecomastia was not present and the testes were normal. Serum beta-human chorionic gonadotropin (HCG) was at an abnormally high level of 4,396 ng/mL. Because of metastases to the brain and invasion to the trachea, he died on postoperative day 20. We report this rare case of a male patient with metastases of choriocarcinoma to the gastrointestinal tract from the mediastinum, together with a review of the literature.  (+info)

Primary intracranial choriocarcinoma: MR imaging findings. (4/10)

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Papillary cystadenofibroma of epididymis: a case report. (5/10)

We present the first reported case of papillary cystadenofibroma of the epididymis. The tumor occurred in a 46-year-old man. The mass was 3.7 cm and included a hemorrhagic fluid-filled cyst. Microscopically, stromal-filled papillae were lined by low cuboidal to columnar epithelium. Epithelial cells were reactive for cytokeratin 7, cytokeratins AE1/3, and focally in the apical cytoplasm for CD10. Focal CD10 reactivity was also noted in the stroma. The lesion was negative for alpha-fetoprotein. These findings ruled out other lesions, including metastatic renal cell carcinoma.  (+info)

Pathological complete response and two-year disease-free survival in a primary gastric choriocarcinoma patient with advanced liver metastases treated with germ cell tumor-based chemotherapy: a case report. (6/10)

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Pure nongestational choriocarcinoma of the ovary: a case report. (7/10)

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma. (8/10)

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Choriocarcinomas can be divided into two types: gestational and non-gestational. Gestational choriocarcinomas mostly occur in woman of reproductive age, usually within one year following a molar or non-molar pregnancy. Non-gestational choriocarcinomas can arise from germ cell or trophoblastic differentiation within endometrial carcinomas. Extraovarian germ cell tumors, including choriocarcinomas may arise from germ cells that failed to complete their migration to the gonads [8]. However, germ cell choriocarcinomas arising from the female genital tract in postmenopausal woman with normal ovaries on CT scan and sonography are extremely rare [3, 9].. When choriocarcinoma occurs in postmenopausal woman, it is difficult to rule out the possibility of trophoblastic differentiation within an endometrial carcinoma. Choriocarcinoma has been reported in association with endometrial carcinoma as well as liver, lung and urinary bladder carcinomas [10]. These types of choriocarcinomas can be diagnosed based ...
TY - JOUR. T1 - Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal neuroendocrine neoplasms. AU - Grover, Amelia C.. AU - Libutti, Steven K.. AU - Pingpank, James F.. AU - Helsabeck, Cynthia. AU - Beresnev, Tatiana. AU - Alexander, H. Richard. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2004/12. Y1 - 2004/12. N2 - We report results of using isolated hepatic perfusion (IHP) in patients with advanced progressive liver metastases (LM) from pancreatic and gastrointestinal neuroendocrine neoplasms (NENs). Thirteen patients with LM from NENs (mean percent hepatic replacement, 30; range, 10-60) were treated with a 1-hour hyperthermic IHP via a laparotomy with the use of 1.5 or 2.0 mg/kg melphalan and/or 1 mg tumor necrosis factor. An oxygenated extracorporeal circuit with inflow through the gastroduodenal artery and common hepatic artery, and outflow to a segment of the inferior vena cava was used. ...
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TY - JOUR. T1 - [Choriocarcinoma in a female infant]. AU - SCHULER, D.. AU - JUHASZ, J.. PY - 1960/1/3. Y1 - 1960/1/3. KW - CHORIOCARCINOMA/in infancy and childhood. KW - GENITALIA, FEMALE/neoplasms. UR - http://www.scopus.com/inward/record.url?scp=84925556201&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84925556201&partnerID=8YFLogxK. M3 - Article. C2 - 14443737. AN - SCOPUS:84925556201. VL - 101. SP - 29. EP - 30. JO - Orvosi Hetilap. JF - Orvosi Hetilap. SN - 0030-6002. ER - ...
Chemotherapy of choriocarcinoma (1 course) (costs for program #197511) ✔ University Hospital Rechts der Isar of the Munich Technical University ✔ Department of Pediatrics ✔ BookingHealth.com
Diagnosis of choriocarcinoma (costs for program #201259) ✔ Academic Hospital Harlaching ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
CASE SUMMARY An otherwise healthy 37-day-old male presented to dermatology with a pedunculated, friable red glabellar mass (centered between the eyes). First...
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Nov 2011 Choi BB, Shu KS. Source Department of Radiology. Correspondence to: Bo Bae Choi. Email: [email protected] Abstract BACKGROUND Metaplastic carcinomas are ductal carcinomas that display metaplastic transformation of the glandular epithelium to non-glandular mesenchymal tissue. Metaplastic carcinoma has a poorer prognosis than most other breast cancers, so the differential diagnosis is important. Although many clinical and pathologic findings have been reported, to our knowledge, few imaging findings related to metaplastic carcinoma have been reported.PurposeTo investigate whole-breast imaging findings, including mammography, sonography, MRI, and pathologic findings, including immunohistochemical studies of metaplastic carcinomas of the breast. MATERIAL AND METHODS: We analyzed 33 cases of metaplastic carcinoma between January 2001 and January 2011. Mammography, ultrasonography, and MRI were recorded ...
Choriocarcinoma is a rare uterine cancer following pregnancy. The tumor arises in the trophoblast cells lining the embryo. Vaginal bleeding is a common symptom.
Esophageal adenocarcinoma (EAC) is an often deadly cancer with a rising incidence in Western countries. Chronic gastroesophageal reflux disease is associated with the metaplastic transformation of normal squamous epithelium to premalignant specialized intestinal metaplasia within the esophagus (Barretts esophagus). Barretts esophagus may progress to low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even EAC. Although nondysplastic Barretts esophagus progresses to EAC at a rate of 0.5% per year, rates of progression for true LGD and HGD are significantly higher. Treatment is mandatory for HGD and may be appropriate in select patients with nondysplastic Barretts esophagus and many with LGD. Thus, accurate pathologic assessment is necessary before considering endoscopic therapy. Previously, only esophagectomy was offered to patients with HGD or EAC. However, esophagectomy has significant morbidity and mortality, and therefore endoscopic therapies have been advocated for early Barretts ...
Choriocarcinoma usually affects premenopausal women. A postmenopausal choriocarcinoma is a rare event and there are few cases reported in the literature. In our case, the tumor clinically was manifested 20 years after the last pregnancy. The biological mechanism behind the long latent period for the gestational choriocarcinoma to develop in a postmenopausal woman has not been described. The gestational choriocarcinoma arises within the uterine cavity, however our case was presented with pulmonary metastatic involvement without evidence of uterine disease (i.e. spontaneous regression of the primary tumor). This behavior is known as the burn-out phenomenon. It has been described mainly in melanoma, as well as in other tumors including the germ cell tumors. A molecular immunological mechanism seems to be involved in this process. The tumor growth and spread cause repetitive exposures of the T-lymphocytes to the primary tumor antigens. The T-cells tend to eliminate the primary lesion, while the ...
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. In our case, a 43-year-old woman was admitted in our hospital because she had amenorrhea for 2 months and elevated serum beta-human chorionic gonadotropin levels. The patient was considered to have an ectopic pregnancy. Initially, she was treated with methotrexate, but since there was a continuous rise in human chorionic gonadotropin levels, the patient underwent a laparoscopy, along with dilatation and curettage (D&C) of the uterine cavity. Histopathologic findings, including immunohistochemical study, led to the diagnosis of choriocarcinoma of the cervix. Finally, the patient underwent a transabdominal hysterectomy and received single agent chemotherapy with methotrexate. Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as ...
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, whole genome sequencing (WGS) and methylation analysis of the tumour and surrounding mature placenta. The results of the WGS sequencing indicated a very low level of mutation and the absence of any driver mutations or oncogene activity in the tumour. The methylation analysis identified a distinctly different profile in the tumour from that of the mature placenta. Comparison with a panel of reference methylation profiles from different stages of placental development indicated that the tumour segregated with the first trimester samples. These findings suggest
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone HCGb/54 ] validated in IHC-P (AH10393-100), Abgent
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM529 ] validated in IHC-P (AH10397-20), Abgent
A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, it happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst) Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus. Chemotherapy is the treatment of choice. In certain cases, a hysterectomy and radiation are ...
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691 ...
We report a 33-year-old woman with intermittent abdominal pain and lower gastrointestinal bleeding. Upper and lower GI endoscopy did not reveal any le..
TY - JOUR. T1 - Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells. T2 - Differential utilization of cis-regulatory elements. AU - Kingsley-Kallesen, Michelle. AU - Johnson, Lance. AU - Scholtz, Beáta. AU - Kelly, David. AU - Rizzino, Angie. PY - 1997/4. Y1 - 1997/4. N2 - Previous studies have shown that the transcription of the TGF-β2 gene is controlled by at least one negative and two positive regulatory regions in differentiated cells derived from both embryonal carcinoma cells and embryonic stem cells. The use of TGF-β2 promoter/reporter gene constructs has also identified a CRE/ATF motif near the TATA box that appears to heavily influence the transcription of the TGF-β2 gene. In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. We demonstrated that both similarities and differences exist ...
Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...
Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a womans uterus (womb). It is a. CancerWORLD Cancer Treatment Research Journal
TY - CHAP. T1 - Metastatic choriocarcinoma to the breast. T2 - Mammography and color doppler ultrasound. AU - Kalra, Naveen. AU - Ojili, Vijaynadh. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2008. Y1 - 2008. N2 - This chapter presents the role of mammography and color Doppler ultrasound in the diagnosis of metastatic choriocarcinoma to the breast. The most common mammographic appearance of metastases is of one or more well-circumscribed masses located in the upper and outer quadrant of the breast. Typically, there is no spiculation, architectural distortion, skin thickening, or other signs of surrounding desmoplastic reaction, which characterize the majority of primary breast carcinomas. However, the mammographic findings of breast metastases can be variable and range from normal to a pattern of diffuse skin thickening that simulates inflammatory carcinoma. The mammographic appearances of metastatic hematologic malignancies can vary from discrete to ill-defined ...
Background: Activated phosphatidylinositol 3-kinase (PI3K) and its downstream serine/threonine protein kinase B (PKB)/AKT are important regulators of cell proliferation, apoptosis and invasion. The activation at Ser473 residue of PKB by phosphorylation (p-PKB Ser473) is required for its maximal activity. Dysregulation of PI3K/PKB signaling pathway has been found to be an important feature of many human malignancies. However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression of p-PKB (Ser473) in gestational trophoblastic disease and the effects of inhibiting PI3K/PKB signaling pathway in choriocarcinoma. Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser473) expression was detected by Western Blot. The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by ...
The symposium had two tracks, including a psychosocial track focused on information for patients, survivors and caregivers that delved into the psychosocial complexities of the AYA oncology population. The scientific track covered specific advances in targeted tumor-based therapy. Lectures by Dr. John Perentesis, Professor and Oncology Division Director at Cincinnati Childrens Hospital, and by Deborah Morosini, Vice President of Clinical Development at Foundation Medicine, highlighted advances in pharmacogenomics and how they are beginning to inform treatment modalities and clinical trials objectives for cancers common to AYA patients.. Lectures by Dr. Brandon Hayes-Latin, Director of the AYA Cancer Program at OHSU, and by Dr. Lindsay Frazier of the Dana Farber Cancer Institute shed light on how reorganization of the NCI infrastructure supporting the clinical trials process is enhancing collaborations between the Childrens Oncology Group and those cooperative groups developing clinical trials ...
Choriocarcinomas can be divided into gestational choriocarcinomas and non-gestational choriocarcinomas which have ... "Choriocarcinoma", Wikipedia, 2019-02-23, retrieved 2019-04-10 Smith HO, Berwick M, Verschraegen CF, Wiggins C, Lansing L, ... OGCTs can be classified into dysgerminoma, teratomas, yolk sac tumors, and choriocarcinomas, listed in the order of prevalence ... There are four main types of OGCTs, namely dysgerminomas, yolk sac tumor, teratoma, and choriocarcinoma. Dygerminomas are ...
"A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature ...
Choriocarcinoma are trophoblastic tumors that form in the uterus from villous cells. Trophoblast stem cells (TSCs) are cells ... Gestational trophoblastic disease is a pregnancy-associated concept, forming from the villous and extravillous trophoblast ... Ning, Fen; Hou, Houmei; Morse, Abraham N.; Lash, Gendie E. (2019-04-10). "Understanding and management of gestational ...
Certain malignancies can mimic the effects of clomifene on the ovaries, also due to increased HCG, in particular gestational ... Ovarian hyperstimulation occurs more often with invasive moles and choriocarcinoma than complete molar pregnancies. A widely ...
... of women who developed choriocarcinoma died within a year. Today, with chemotherapy, choriocarcinoma can be cured in almost ... Li, Min C. (15 September 1979). "The historical background of successful chemotherapy for advanced gestational trophoblastic ... Yarris, Jonathan P; Hunter, Alan J (1 May 2003). "Roy Hertz, M.D. (1909-2002): The cure of choriocarcinoma and its impact on ... Within four months she was "normal without evidence of disease." Li treated two additional patients with choriocarcinoma that ...
Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease ... Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ...
... of all gestational trophoblastic proliferations. Preceding conditions include molar pregnancy (5%). Compared to choriocarcinoma ... Placental site trophoblastic tumor is a form of gestational trophoblastic disease, which is thought to arise from intermediate ...
The choriocarcinoma has 2 significant subtypes including gestational and non-gestational and they are differentiated by their ... Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational ... "References: Gestational Trophoblastic Disease". www.cancer.org. Retrieved 2020-12-16. "Gestational Trophoblastic Disease - Risk ... "Gestational Trophoblastic Disease - Diagnosis". Cancer.Net. 2012-06-25. Retrieved 2020-12-16. "Gestational Trophoblastic ...
... on Chromosome 14 that are highly expressed in gestational choriocarcinoma. The EFS mRNA was also identified as differentially ...
... gestational trophoblastic diseases (GTD), and gestational trophoblastic neoplasms). bacterial contamination and blood in urine ... including choriocarcinoma and other germ cell tumors, IgA deficiencies, heterophile antibodies, enterocystoplasties, ... With obstetric ultrasonography the gestational sac (intrauterine fluid collection) can be visualized at 4.5 to 5 weeks ... to 10-weeks gestational age. hCG is produced by what will become the placenta. hCG testing can be performed with a blood (serum ...
... choriocarcinoma MeSH C04.557.465.955.207.750 - choriocarcinoma, non-gestational MeSH C04.557.465.955.207.875 - trophoblastic ... choriocarcinoma MeSH C04.557.470.200.025.455.750 - choriocarcinoma, non-gestational MeSH C04.557.470.200.025.455.875 - ... gestational trophoblastic neoplasms MeSH C04.850.908.416.186 - choriocarcinoma MeSH C04.850.908.416.186.875 - trophoblastic ... choriocarcinoma MeSH C04.557.465.955.416.202.875 - trophoblastic tumor, placental site MeSH C04.557.465.955.416.812 - ...
... gestational trophoblastic neoplasms MeSH C13.703.720.949.416.218 - choriocarcinoma MeSH C13.703.720.949.416.218.875 - ...
Gestational trophoblastic disease like hydatidiform moles ("molar pregnancy") or choriocarcinoma may produce high levels of ... choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with elements of choriocarcinoma, and islet cell tumor. For this ... A study of 32 normal pregnancies came to the result a gestational sac of 1-3 mm was detected at a mean hCG level of 1150 IU/l ( ... It is also possible to test for hCG to have an approximation of the gestational age. Most tests employ a monoclonal antibody, ...
... including choriocarcinoma, a highly invasive cancer. This article incorporates text in the public domain from page 60 of the ... usually due to bacterial infection Chorionic hematoma Gestational trophoblastic disease, any abnormal proliferation of the ...
... even for metastatic gestational choriocarcinoma, more than 90% when using chemotherapy for invasive mole and choriocarcinoma. ... Stage I choriocarcinoma Stage 2 choriocarcinoma Stage 3 choriocarcinoma Stage 4 choriocarcinoma "choriocarcinoma" at Dorland's ... Since gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), ... Elements of choriocarcinoma in a mixed testicular tumor have no prognostic importance. Choriocarcinomas can also occur in the ...
... is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ... "Choriocarcinoma". Retrieved 10 August 2012. CS1 maint: discouraged parameter (link) NIH. "Choriocarcinoma". Retrieved 10 August ...
Gestational trophoblastic disease like hydatidiform moles ("molar pregnancy") or choriocarcinoma may produce high levels of ... choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with elements of choriocarcinoma, and islet cell tumor. For this ... A study of 32 normal pregnancies came to the result a gestational sac of 1-3 mm was detected at a mean hCG level of 1150 IU/l ( ... These can be done to diagnose and monitor germ cell tumors and gestational trophoblastic diseases. ...
Izhar R (2003). "Prognosis of gestational choriocarcinoma at Khyber Teaching Hospital Peshawar". Journal of Ayub Medical ... "Gestational Trophoblastic Disease". Gestational Trophoblastic Disease Lipata F, Parkash V, Talmor M, Bell S, Chen S, Maric V, ... Choriocarcinoma, for example, is an uncommon, yet almost always curable cancer. Although choriocarcinoma is a highly malignant ... Gestational trophoblastic disease (GTD) may also be called gestational trophoblastic tumour (GTT). Hydatidiform mole (one type ...
Choriocarcinoma. *Gestational trophoblastic disease. General. *Uterine sarcoma. *Mixed Müllerian tumor. Vagina. *Squamous-cell ...
Trophoblastic neoplasm: Gestational trophoblastic disease *Hydatidiform mole. *Choriocarcinoma. *Placental site trophoblastic ...
... and Percentiles by Gestational Age". Placental and Gestational Pathology: 336. doi:10.1017/9781316848616.039. ISBN ... They are decreased with toxemia, choriocarcinoma, and Placental insufficiency. The placenta and fetus may be regarded as a ... This transfer of antibodies begins as early as the 20th week of gestational age, and certainly by the 24th week. This passive ... of same placenta Close-up of umbilical attachment to fetal side of freshly delivered placenta Placenta weight by gestational ...
A molar pregnancy is a gestational trophoblastic disease which grows into a mass in the uterus that has swollen chorionic villi ... risk of developing into choriocarcinoma in Western countries and 10-15% in Eastern countries and a 15% risk of becoming an ...
... gestational trophoblastic disease - gestational trophoblastic neoplasia - gestational trophoblastic tumor - GI14721 - giant ... choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic leukemia - chronic idiopathic myelofibrosis - chronic ...
Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and ... Min Chiu Li and his collaborators then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956 ... Hertz R, Li MC, Spencer DB (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". ...
They are decreased with toxemia, choriocarcinoma, and Placental insufficiency.[29][30]. Immunological barrierEdit. Further ... This transfer of antibodies begins as early as the 20th week of gestational age, and certainly by the 24th week.[28] This ...
She was later diagnosed with choriocarcinoma, a form of cancer that occurs in a women's uterus. Some of the common causes of ... Provisions to increase the gestation limit for abortions: It is recommended to increase the gestational limit for seeking ...
Trophoblastic neoplasm: Gestational trophoblastic disease *Hydatidiform mole. *Choriocarcinoma. *Placental site trophoblastic ...
Gestational trophoblastic disease, any abnormal proliferation of the trophoblasts, including choriocarcinoma, a highly invasive ...
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ... "Choriocarcinoma". Retrieved 10 August 2012. CS1 maint: discouraged parameter (link) NIH. "Choriocarcinoma". Retrieved 10 August ...
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY ... Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational ... Non-gestational Choriocarcinoma (Choriocarcinoma, Non gestational). Subscribe to New Research on Non-gestational ... 01/01/1986 - "Eight choriocarcinoma cell lines (Two SCH and IMa, were established from non-gestational choriocarcinoma and the ...
Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational, is related to choriocarcinoma of ovary and ... MalaCards integrated aliases for Non-Gestational Choriocarcinoma:. Name: Non-Gestational Choriocarcinoma 12 15 17 ... MalaCards organs/tissues related to Non-Gestational Choriocarcinoma:. 42 Ovary, Cervix, Lung, Small Intestine ... MGI Mouse Phenotypes related to Non-Gestational Choriocarcinoma:. 47 #. Description. MGI Source Accession. Score. Top ...
These findings suggest that gestational choriocarcinoma is likely to arise as a result of aberrations of methylation during ... The results support the hypothesis that gestational choriocarcinoma arises from a normally transient early trophoblast cell. At ... Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for ... In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, ...
Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and primary non-gestational choriocarcinoma of ... MalaCards integrated aliases for Non-Gestational Ovarian Choriocarcinoma:. Name: Non-Gestational Ovarian Choriocarcinoma 12 15 ... MalaCards organs/tissues related to Non-Gestational Ovarian Choriocarcinoma:. 42 Ovary, Brain, Pituitary, Cervix, B Cells ... Articles related to Non-Gestational Ovarian Choriocarcinoma:. #. Title. Authors. Year. 1. Clinical and ultrasound features of ...
Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a womans uterus ... Choriocarcinoma. Choriocarcinoma is a malignant form of gestational trophoblastic disease (GTD). It is much more likely than ... You might hear GTDs called gestational trophoblastic disease, gestational trophoblastic tumors, or gestational trophoblastic ... Half of all gestational choriocarcinomas start off as molar pregnancies. About one-quarter develop in women who have a ...
Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature ... Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. ... Primary gestational choriocarcinoma of the uterine cervix. Report of a case and review of the literature ... Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. In our case, a 43- ...
Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Gestational trophoblastic disease treatment (PDQ) - health professional version. www.cancer.gov/cancertopics/pdq/treatment/ ... Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy. ... Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ...
Little is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant ... Distinct genomic profiles of gestational choriocarcinoma, a unique cancer of pregnant tissues Seung-Hyun Jung 1 2 , Youn Jin ... Distinct genomic profiles of gestational choriocarcinoma, a unique cancer of pregnant tissues Seung-Hyun Jung et al. Exp Mol ... Little is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant ...
Genomic profile in gestational and non-gestational choriocarcinomas.. Mello JB1, Ramos Cirilo PD2, Michelin OC3, Custódio ... Gestational (GC) (derived from the placenta) and non-gestational (NGC) choriocarcinomas are trophoblastic diseases originated ... Array comparative genomic hybridization; Copy number alteration; Gestational choriocarcinoma; Microsatellites; Non-gestational ... All choriocarcinomas were evaluated by copy number alterations using array CGH.. RESULTS: Eight cases were classified as GC and ...
I learned these firsthand when I was on the aggressive 5 agent cocktail known as ema-co for placental cancer choriocarcinoma ...
Choriocarcinoma. *Choriocarcinoma is a malignant tumor of the trophoblastic epithelium.[17]. *Cytotrophoblastic cells, ... Smith, Harriet O.; Kohorn, Ernest; Cole, Laurence A. (2005). "Choriocarcinoma and Gestational Trophoblastic Disease". ... Choriocarcinoma can invade the uterine tissue and vasculature and spread to distant sites such as lungs, brain, liver, pelvis, ... Choriocarcinoma. *Bulky, destructive mass with hemorrhage and necrosis[37][38]. *Can be associated with deep myometrial ...
If you or your loved one has been diagnosed with gestational trophoblastic disease, Memorial Sloan Kettering is ready to help. ... Choriocarcinoma. A choriocarcinoma is even rarer than a hydatidiform mole. This type of GTD may have begun as a hydatidiform ... Gestational Trophoblastic Disease More About Gestational Trophoblastic Disease Diagnosis & Treatment of Gestational ... A choriocarcinoma can also spread more widely to other parts of the body such as the lungs, liver, and/or brain. ...
Choriocarcinoma FIGO Stage I Gestational Trophoblastic Tumor FIGO Stage II Gestational Trophoblastic Tumor FIGO Stage III ... Patients with non-gestational choriocarcinoma. *Patients who have previously been treated with cytotoxic chemotherapy; however ... Choriocarcinoma. Trophoblastic Neoplasms. Gestational Trophoblastic Disease. Hydatidiform Mole. Neoplasms, Germ Cell and ... Genetic and Rare Diseases Information Center resources: Gestational Trophoblastic Tumor Choriocarcinoma Hydatidiform Mole ...
Gestational Trophoblastic Neoplasia. There are several types of gestational trophoblastic neoplasia:. * Choriocarcinoma: This ... What is gestational trophoblastic disease?. Gestational trophoblastic disease (GTD) is the term given to a group of rare tumors ... What You Need to Know - Gestational Trophoblastic Disease (GTD). * Gestational trophoblastic disease is the name given to a ... Choriocarcinomas usually occur when growths from molar pregnancies turn cancerous. Rarely, choriocarcinomas form from tissue ...
They include hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). The incidence of ... Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease. The safety and scientific ... 1 Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal ... Gestational Trophoblastic Disease. Trophoblastic Neoplasms. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. ...
Gestational Trophoblastic Disease (Choriocarcinoma) [PDF] Remove: NHS England source survival results have been seen with other ...
Differentiating Choriocarcinoma From Other Diseases. Gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, ... Baergen RN (November 1997). "Gestational choriocarcinoma". Gen Diagn Pathol. 143 (2-3): 127-41. PMID 9443570.. ... Smith HO, Kohorn E, Cole LA (December 2005). "Choriocarcinoma and gestational trophoblastic disease". Obstet. Gynecol. Clin. ... Gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental-site trophoblastic tumor [PSTT] and epitheloid ...
Gestational Trophoblastic Disease (Choriocarcinoma) [PDF] Remove: NHS England source ) conference Cochin and J Reprod Med 2013 ...
Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a womans uterus (womb ... Choriocarcinoma (a type of cancer). *Hydatiform mole (also called a molar pregnancy) ... Bouchard-Fortier G, Covens A. Gestational trophoblastic disease: hydatidiform mole, nonmetastatic and metastatic gestational ... Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a womans uterus (womb ...
Two types of choriocarcinoma have been described: gestational and non-gestational. Usually, gestational choriocarcinoma occurs ... There was no history of gestational trophoblastic disease. Figure 2: Pulmonary metastatic gestational choriocarcinoma. * H&E ... Gestational and non-gestational choriocarcinoma are clinically and pathologically indistinguishable. The only reliable ... It confirmed a gestational type of metastatic choriocarcinoma (Figure 2B). She was started on chemotherapy. EMA/CO (etoposide, ...
... referred to as gestational trophoblastic disease or GTD for short. ... Gestational Trophoblastic Disease and Choriocarcinoma * Surgical Procedures: Surgery and Staging for Gestational Trophoblastic ... Gestational choriocarcinoma is a fast growing tumor which has the potential to spread to other parts of the body including the ... Gallbladder Cancer Gastric Cancer Gastrointestinal Cancers Gestational Trophoblastic Disease and Choriocarcinoma Gynecologic ...
Gestational trophoblastic disease (GTD) is a rare group of interrelated tumors that develop after conception and lead to ... Choriocarcinoma. Choriocarcinoma is a highly malignant form of GTD that spreads rapidly throughout the body and requires ... About Gestational Trophoblastic Disease (GTD). * Gestational trophoblastic disease (GTD) is a rare group of interrelated tumors ... Women who develop choriocarcinoma may be symptom-free or experience symptoms based on which organ(s) is (are) involved:. * ...
As first-line chemotherapy, pulse Act-D was effective and tolerable for patients with low-risk post-molar non-choriocarcinoma. ... non-choriocarcinoma post-molar GTN. From January 2013 to October 2016, according to the FIGO criteria for the diagnosis of post ... disease and the FIGO risk-factor scoring system for GTN, a total of 135 patients with post-molar non-choriocarcinoma GTN who ... single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D ...
... but choriocarcinoma is malignant. Approximately 45% of patients have metastatic disease when Gestational trophoblastic ... Introduction Gestational trophoblastic diseases (GTD) is the only group of female reproductive neoplasms derived from paternal ... New Management of Gestational trophoblastic diseases; A Continuum of Moles to Choriocarcinoma: A Review Article ... but choriocarcinoma is malignant. Approximately 45% of patients have metastatic disease when Gestational trophoblastic ...
Placental (Gestational trophoblastic tumours (GTTs)). There are a number of organisations providing expert advice on these ... including molar pregnancy and choriocarcinoma, in England. The websites have information about these conditions for patients ... Placental cancer (Gestational trophoblastic tumours (GTTs)) charities and information sources. Hydatidiform Mole and ... the two specialist screening and treatment centres for gestational trophoblastic disease, ...
When the tumor develops during pregnancy, its called gestational choriocarcinoma. Gestational choriocarcinoma most often ... Choriocarcinoma. Choriocarcinoma is a very rare, but often malignant germ cell tumor that arises from the cells in the chorion ... If a nonpregnant young child develops choriocarcinoma from the chorion cells that originated from the placenta that are still ...
Choriocarcinoma, chorioadenoma, gestational trophoblastic diseases: 15 to 30 mg oral or IM daily for a 5 day course; may repeat ... Methotrexate is approved for the treatment of trophoblastic neoplasms (gestational choriocarcinoma, chorioadenoma destruens, ... gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole), breast cancer, head and neck cancer (epidermoid), ...
Gestational age 2 weeks older than embryonic age because is based on LMP which is 14 d prior to fertilization which occurs at ... Which is older, gestational age or embryonic/developmental age? by how much ...
Gestational trophoblastic neoplasia / molar pregnancy. Tumour of trophoblastic tissue. Choriocarcinoma. Malignant tumour of ... Gestational diabetes. Development of glucose intolerance during pregnancy. Rhesus isoimmunization. Maternal immune response ...
  • Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. (cancer.org)
  • You might hear GTDs called gestational trophoblastic disease, gestational trophoblastic tumors, or gestational trophoblastic neoplasia. (cancer.org)
  • Gestational trophoblastic disease is the name given to a group of tumors that form during abnormal pregnancies. (hopkinsmedicine.org)
  • Gestational trophoblastic disease (GTD) is the term given to a group of rare tumors that develop during the early stages of pregnancy. (hopkinsmedicine.org)
  • Gestational trophoblastic disease (GTD) is a group of rare tumors that begin during a pregnancy. (mskcc.org)
  • As stated, some of these molar pregnancies are cancerous, including choriocarcinoma, placental-site trophoblastic tumors, and epithelioid trophoblastic tumors. (oncolink.org)
  • While most cases of choriocarcinoma develop from complete molar pregnancies, there are some women who experience the condition following delivery, after a miscarriage, ectopic pregnancy, abortion or other tumors of the genital tract. (oncolink.org)
  • As in choriocarcinoma, these tumors invade through the muscular wall of the uterus and into the blood vessels surrounding the uterus. (oncolink.org)
  • Gestational trophoblastic disease (GTD) is a rare group of interrelated tumors that develop after conception and lead to abnormal development of the placenta. (dana-farber.org)
  • One must be cautious while taking a biopsy of the choriocarcinoma due to the high chance of bleeding, as such tumors are high in blood vessels. (medindia.net)
  • In non-gestational ovarian tumors, a DNA polymorphism test is useful in differentiating them from gestational tumors. (medindia.net)
  • Most gestational trophoblastic tumors are benign (not cancer) and do not spread, but some types are malignant (cancer) and spread to nearby tissues or other parts of the body. (cancer.gov)
  • The two main types of gestational trophoblastic tumors are hydatidiform mole and choriocarcinoma. (cancer.gov)
  • A common characteristic of all gestational trophoblastic disease is an abnormal proliferation of trophoblast, but different components predominate in different tumors. (radiopaedia.org)
  • These include complete and partial moles, placental site trophoblastic tumors, choriocarcinomas, and invasive moles. (medscape.com)
  • Performed by an interventional radiologist, selective embolization of the uterine artery is reported as a well-tolerated and effective treatment option for managing severe bleeding from residual uterine vascular malformations in patients with gestational trophoblastic tumors that have been treated. (medscape.com)
  • Considered one of the fastest growing tumors, infantile choriocarcinoma classically presents with hepatomegaly, anemia, failure to thrive, and precocious puberty between 0 days and 5 months of life. (appliedradiology.com)
  • Concerning gestational trophoblastic disease, my research interests have concerned identifying risk factors for development of these tumors as well as advancing understanding of the natural history of these diseases including subsequent reproductive experience. (harvard.edu)
  • Gestational trophoblastic tumors, including hydatidiform moles and choriocarcinomas, are uncommon causes of hyperthyroidism during pregnancy. (renalandurologynews.com)
  • This rare condition is called gestational trophoblastic disease or GTD. (oncolink.org)
  • Also called gestational trophoblastic disease, GTD, and GTT. (cancer.gov)
  • The most common form of gestational trophoblastic disease (GTD) is a hydatidiform mole, also known as a molar pregnancy . (cancer.org)
  • About one half of all women with a choriocarcinoma had a hydatidiform mole, or molar pregnancy. (medlineplus.gov)
  • They include hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). (clinicaltrials.gov)
  • A choriocarcinoma is even rarer than a hydatidiform mole. (mskcc.org)
  • Unlike a hydatidiform mole, a choriocarcinoma is a malignant and more aggressive form of GTD that spreads into the muscle wall of the uterus. (mskcc.org)
  • Gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental-site trophoblastic tumor [PSTT] and epitheloid trophoblastic tumor [ETT]) should be differentiated from other conditions presenting with similar symptoms and signs such as increase in uterine size, vaginal bleeding and amenorrhea . (wikidoc.org)
  • Bouchard-Fortier G, Covens A. Gestational trophoblastic disease: hydatidiform mole, nonmetastatic and metastatic gestational trophoblastic tumor: diagnosis and management. (medlineplus.gov)
  • A hydatidiform mole, also called a molar pregnancy, is a form of gestational trophoblastic disease that arises when fertilization of an egg results in an abnormal pregnancy. (dana-farber.org)
  • treatment of trophoblastic neoplasms (gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole), breast cancer, head and neck cancer (epidermoid), cutaneous T-Cell lymphoma (advanced mycosis fungoides), lung cancer (squamous cell and small cell), advanced non-Hodgkin lymphomas (NHL), osteosarcoma (preservative-free only). (drugs.com)
  • Histologic type (invasive mole or choriocarcinoma). (wellspan.org)
  • The four malignant tumours Invasive mole Choriocarcinoma Placental site trophoblastic tumour Epithelioid trophoblastic tumour All five closely related tumours develop in the placenta. (wikipedia.org)
  • If blood levels of human chorionic gonadotropin (HCG or b-HCG) start to stabilize, rise or are still measureable after a few months following surgery for a hydatidiform mole, it means you have a persistent mole (such as an invasive mole or a choriocarcinoma), which will need to be treated further with chemotherapy. (cancer.ca)
  • I have had a partial mole and persistant gestational trophoblastic disease. (buzzle.com)
  • Sometimes, the hydatidiform mole spreads to surrounding tissues and becomes malignant, resulting in choriocarcinoma. (medindia.net)
  • If the blood HCG level begins to rise or is still detectable after a reasonable time (often around 4 to 6 months), it means that the patient has persistent GTD (such as an invasive mole or choriocarcinoma). (cancer.org)
  • Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). (harvard.edu)
  • A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). (fpnotebook.com)
  • Molar pregnancy and gestational trophoblastic neoplasms (GTNs) comprise a group of interrelated diseases, including complete and partial molar pregnancy, invasive mole, choriocarcinoma, epithelioid trophoblastic tumor and placental site trophoblastic tumor, which have varying propensities for local invasion and metastasis. (clinicaladvisor.com)
  • β -human chorionic gonadotropin (HCG) level is not a reliable marker for early identification of persistent gestational trophoblastic neoplasia (GTN) after evacuation of hydatidiform mole. (hindawi.com)
  • GTN includes complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), invasive mole, choriocarcinoma, and placental-site trophoblastic tumor (PSTT). (medscape.com)
  • Magnified transverse sonogram shows a complete hydatidiform mole (CHM) at 7 weeks of menstrual age with a small anembryonic gestational sac. (medscape.com)
  • Sagittal endovaginal sonogram of a complete hydatidiform mole (CHM) at 12 weeks of menstrual age demonstrates an enlarged endometrium containing an anembryonic gestational sac with adjacent hyperechoic material containing tiny anechoic spaces. (medscape.com)
  • Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole. (biomedsearch.com)
  • Gestational choriocarcinoma is a form of gestational trophoblastic disease, which arises from a partial mole, a complete mole, or a normal pregnancy. (oatext.com)
  • These include premalignant lesions: hydatidiform mole (complete and partial) and malignant disorders: invasive mole, choriocarcinoma, placental site trophoblastic tumor and miscellaneous trophoblastic lesions. (icd9data.com)
  • The incidence of choriocarcinoma is higher in patients with complete hydatidiform mole. (icd9data.com)
  • For the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. (nextbio.com)
  • Gestational (GC) (derived from the placenta) and non-gestational (NGC) choriocarcinomas are trophoblastic diseases originated from abnormal proliferation of trophoblastic cells. (cdc.gov)
  • Gestational trophoblastic neoplasia arises from the trophoblastic tissue, which provides nutrients to the embryo and develops into a large part of the placenta . (wikidoc.org)
  • Infantile choriocarcinoma of the liver: This is a very rare tumor that starts in the placenta and spreads to the fetus . (cancer.gov)
  • The cells that form gestational trophoblastic tumours are called trophoblasts and come from tissue that grows to form the placenta during pregnancy. (wikipedia.org)
  • In choriocarcinoma, the placenta that begins to form during pregnancy is replaced by a rapidly growing abnormal tissue. (buzzle.com)
  • A placental-site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic neoplasia that forms where the placenta attaches to the uterus. (peacehealth.org)
  • Gestational trophoblastic disease encompasses several disease processes that originate in the placenta. (medscape.com)
  • Gestational trophoblastic disease is a group of disorders that develop from cells (called trophoblasts) that surround a developing embryo and that eventually form the placenta and amniotic sac. (merckmanuals.com)
  • A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells. (icd9data.com)
  • 12 An ovarian primitive germ cell tumor that has material basis in trophoblastic cells and develops in the absence of a preceding gestational event. (malacards.org)
  • Choriocarcinoma is a malignant tumor of the trophoblastic epithelium . (wikidoc.org)
  • Interestingly, the tumoral lesions corresponded to a choriocarcinoma, a malignant βhCG-producer epithelial tumor, formed by cytotrophoblast-like cells and multinucleated syncytiotrophoblast-like regions. (medcraveonline.com)
  • Gestational choriocarcinoma is a fast growing tumor which has the potential to spread to other parts of the body including the brain, lungs, liver, kidney, spleen, intestines, pelvis and/or vagina. (oncolink.org)
  • Gestational trophoblastic diseases can be benign (hydatidiform moles or HM) and localized to the site of tumor development, or malignant (gestational trophoblastic neoplasia - GTN) and spread to other regions of the body. (medindia.net)
  • In either case, once the tumor is removed, a pathologist will look at it with a microscope for signs of choriocarcinoma or other malignant changes in the specimen. (cancer.org)
  • Choriocarcinoma These cancerous placental tumor cells grow fast. (uwhealth.org)
  • In gestational trophoblastic disease (GTD), a tumor develops inside the uterus from tissue that forms after conception (the joining of sperm and egg). (peacehealth.org)
  • A choriocarcinoma is a malignant tumor that forms from trophoblast cells and spreads to the muscle layer of the uterus and nearby blood vessels. (peacehealth.org)
  • An epithelioid trophoblastic tumor (ETT) is a very rare type of gestational trophoblastic neoplasia that may be benign or malignant. (peacehealth.org)
  • Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. (radiopaedia.org)
  • Epithelioid trophoblastic tumor (ETT) is a malignant gestational neoplasm first described as a distinct entity in 1998 by Shih and Kurman [ 1 ]. (hindawi.com)
  • We describe 2 cases of β -HCG secreting malignancy in young women that exemplify the potential value of RLP analysis as an adjunctive test in separating somatic carcinoma from gestational trophoblastic tumor. (hindawi.com)
  • The differential diagnosis of lesions presenting with cutaneous involvement (ordered most to least common) include: leukemia, Langerhans cell histiocytosis, neuroblastoma, rhabdoid tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, choriocarcinoma, and adrenocortical carcinoma. (appliedradiology.com)
  • Choriocarcinoma is notorious for its life-threating hemorrhagic metastases and famous for being the first solid tumor to be cured with chemotherapy alone (methotrexate, 1956). (appliedradiology.com)
  • Choriocarcinoma of the ovary is a rare and highly malignant germ cell tumor. (oatext.com)
  • There are three ways in which an ovarian choriocarcinoma can arise: as a primary gestational choriocarcinoma that results from an ectopic ovarian pregnancy, as a metastatic choriocarcinoma that arises from a gestational choriocarcinoma, and as a germ cell tumor with differentiation into trophoblastic structures. (oatext.com)
  • By examining the DNA composition of the tumor and comparing it to the maternal and paternal DNA, the etiology of the choriocarcinoma can be determined. (oatext.com)
  • If the DNA of the tumor exactly matches the maternal DNA, the tumor is of non-gestational origin. (oatext.com)
  • However, if the tumor contains any alleles matching paternal DNA, the tumor is of gestational origin [5]. (oatext.com)
  • It may also become a malignant tumor called choriocarcinoma. (icd9data.com)
  • Hydatidiform moles are benign in most cases, but sometimes may develop into invasive moles, or, in rare cases, into choriocarcinoma, which is likely to spread quickly, but which is very sensitive to chemotherapy, and has a very good prognosis. (wikipedia.org)
  • Hydatidiform moles are a type of gestational trophoblastic disease. (merckmanuals.com)
  • About 2 to 3% of hydatidiform moles develop into choriocarcinomas. (merckmanuals.com)
  • In this study, the genomic profile of choriocarcinomas was performed according to their origin (GC or NGC) aiming to better understand these poorly characterized diseases. (cdc.gov)
  • Introduction Gestational trophoblastic diseases (GTD) is the only group of female reproductive neoplasms derived from paternal genetic material (Androgenic origin). (jogcr.com)
  • Diseases associated with EBF4 include Gestational Choriocarcinoma . (genecards.org)
  • Diseases associated with ENPEP include Neurogenic Hypertension and Gestational Choriocarcinoma . (genecards.org)
  • Current management of gestational trophoblastic diseases. (uwhealth.org)
  • Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. Epidemiology and aetiology of gestational trophoblastic diseases. (freemd.com)
  • Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception. (peacehealth.org)
  • Gestational trophblastic disease (GTD) represents a spectrum of diseases characterized by the abnormal growth of trophoblastic tissue. (cedars-sinai.edu)
  • Gestational trophoblastic neoplasia (GTN) represents a spectrum of premalignant and malignant diseases that occur after abnormal fertilization. (medscape.com)
  • Choriocarcinoma is a type of gestational trophoblastic disease . (medlineplus.gov)
  • The following are the standard treatment options according to the type of gestational trophoblastic disease (GTD) and the stage and prognostic group of the disease . (cancer.org)
  • Gestational trophoblastic neoplasia (GTN) is a type of gestational trophoblastic disease (GTD) that is almost always malignant. (peacehealth.org)
  • Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. (wikipedia.org)
  • Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. (wikipedia.org)
  • The term gestational refers to pregnancy. (cancer.org)
  • Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. (bmj.com)
  • Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as an ectopic pregnancy. (bmj.com)
  • I learned these firsthand when I was on the aggressive 5 agent cocktail known as ema-co for placental cancer choriocarcinoma from my complete twin molar pregnancy. (choriocarcinomamolarpregnancyawareness.com)
  • Choriocarcinoma most commonly follows a molar pregnancy , spontaneous abortion , or ectopic pregnancy . (wikidoc.org)
  • Less commonly, choriocarcinoma can also follow a full-term pregnancy . (wikidoc.org)
  • Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. (medlineplus.gov)
  • Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). (medlineplus.gov)
  • A woman with a choriocarcinoma may register a positive home urine pregnancy. (mskcc.org)
  • Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a woman's uterus (womb). (medlineplus.gov)
  • However, in this case, genotyping contributes to the deduction that it was a metastatic gestational choriocarcinoma arising in a post-menopausal woman without evidence of uterine after 20 years of her last pregnancy. (medcraveonline.com)
  • Women who have had a previous molar pregnancy or choriocarcinoma are at increased risk. (dana-farber.org)
  • molar pregnancy is benign, but choriocarcinoma is malignant. (jogcr.com)
  • Websites of the Charing Cross Hospital Trophoblast Disease Service and the Sheffield Trophoblastic Disease Centre, the two specialist screening and treatment centres for gestational trophoblastic disease, including molar pregnancy and choriocarcinoma, in England. (ncin.org.uk)
  • Choriocarcinoma most commonly follows a molar pregnancy but can follow a normal pregnancy, ectopic pregnancy, or abortion, and it should always be considered when a patient has continued vaginal bleeding in the postdelivery period. (cigna.com)
  • Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. (wikipedia.org)
  • The symptoms of gestational trophoblastic disease may resemble those of a normal pregnancy. (newhopemedicalcenter.com)
  • Since choriocarcinoma occurs most often as a result of pregnancy, it is called gestational choriocarcinoma. (medindia.net)
  • If the hCG levels are high and choriocarcinoma is suspected due to an earlier pregnancy, then other tests are conducted. (medindia.net)
  • In the genetic analysis, you will be able to understand the type of pregnancy that caused choriocarcinoma. (medindia.net)
  • Doctors recommend that women avoid becoming pregnant during the first year after diagnosis because pregnancy would raise HCG levels and make it harder to know if any molar tissue is left or if there is choriocarcinoma. (cancer.org)
  • Recurrent Cerebral Hemorrhage in Normal Pregnancy Secondary to Mycotic Pseudoaneurysms Related to Choriocarcinoma. (harvard.edu)
  • Gestational Trophoblastic Disease (GTD) Types of Gestational Trophoblastic Disease (GTD): Benign - Non Cancer Molar pregnancy - when sperm and an egg join without resulting in a pregnancy. (uwhealth.org)
  • The overall purpose of this study is to determine the efficacy of a pre-pregnancy lifestyle intervention to reduce the recurrence of gestational diabetes mellitus in multiethnic women with. (bioportfolio.com)
  • Persistent gestational trophoblastic neoplasia (GTN) may occur following a partial or complete molar pregnancy. (clinicaladvisor.com)
  • Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute pancreatitis in a 27-yr-old woman following a molar pregnancy. (medworm.com)
  • Human chorionic gonadotropin (HCG) is a glycoprotein hormone comprising two subunits, alpha and beta, and is an important index for pregnancy and gestational trophoblastic disease [ 6 , 7 ]. (hindawi.com)
  • Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (biomedsearch.com)
  • Choriocarcinoma coexisting with or after an otherwise "normal" pregnancy is extremely rare, with an estimated occurrence of 1 per 160,000 pregnancies. (biomedsearch.com)
  • We here report a case of a placental choriocarcinoma with no metastases in a full-term intrauterine pregnancy. (biomedsearch.com)
  • Nongestational choriocarcinoma does not arise from a pregnancy event and is an extremely rare occurrence. (oatext.com)
  • Traditionally, a definitive diagnosis of nongestational choriocarcinoma has been restricted to prepubescent females in whom the possibility of a pregnancy event can be eliminated with certainty. (oatext.com)
  • Another less common form is gestational diabetes, a temporary condition that occurs during pregnancy. (amazonaws.com)
  • Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and primary non-gestational choriocarcinoma of ovary . (malacards.org)
  • Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational , is related to choriocarcinoma of ovary and endometrial cancer . (malacards.org)
  • Choriocarcinoma is a fast-growing cancer that occurs in a woman's uterus (womb). (medlineplus.gov)
  • Often, it is not cancerous, yet there are some forms of the condition in which cancer can develop (gestational trophoblastic neoplasia). (oncolink.org)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of gestational trophoblastic disease. (oncolink.org)
  • Gestational trophoblasts are of particular interest to cell biologists because, like cancer, these cells invade tissue (the uterus), but unlike cancer, they sometimes "know" when to stop. (wikipedia.org)
  • Choriocarcinoma is a form of cancer that occurs in the female reproductive system. (buzzle.com)
  • Choriocarcinoma is a type of cancer that develops in a woman's uterus (womb). (buzzle.com)
  • Durable remission for a woman with refractory choriocarcinoma treated with anti-endoglin monoclonal antibody and bevacizumab: A case from the New England Trophoblastic Disease Center, Brigham and Women's Hospital and Dana-Farber Cancer Institute. (harvard.edu)
  • After gestational trophoblastic neoplasia has been diagnosed, tests are done to find out if cancer has spread from where it started to other parts of the body. (amazonaws.com)
  • There are also some rare extrathyroidal causes of thyrotoxicosis, including struma ovarii, functioning metastatic follicular thyroid cancer, and choriocarcinoma of the testis. (renalandurologynews.com)
  • Almost all women with malignant gestational trophoblastic disease can be cured with preservation of reproductive function. (medscape.com)
  • An important gene associated with Non-Gestational Ovarian Choriocarcinoma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway . (malacards.org)
  • Non-gestational ovarian choriocarcinoma is observed in pre-pubertal girls. (medindia.net)
  • Ovarian choriocarcinomas are therefore classified as gestational or nongestational . (oatext.com)
  • The incidence of primary ovarian nongestational choriocarcinoma is estimated to be 1 in 369,000,000 [4]. (oatext.com)
  • published a comprehensive literature review on pure ovarian choriocarcinoma [6]. (oatext.com)
  • The study classified all published cases of pure ovarian choriocarcinoma at the time into three categories: gestational ovarian choriocarcinoma, pure nongestational ovarian choriocarcinoma, and choriocarcinoma of uncertain etiology. (oatext.com)
  • The pure nongestational ovarian choriocarcinoma category was assigned to all pure ovarian choriocarcinoma cases occurring in prepubertal females, and the uncertain etiology was assigned to all pure ovarian choriocarcinoma cases in postpubertal women who were said to be sexually abstinent or virginal. (oatext.com)
  • During the past twenty years, the focus of my research has been in the areas of gestational trophoblastic disease and ovarian neoplasia. (harvard.edu)
  • A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. (curehunter.com)
  • She has stage two non-gestational choriocarcinoma of the ovary. (allnurses.com)
  • Choriocarcinoma of the ovary can be pure choriocarcinoma or, more commonly, mixed with other germ cell components [1]. (oatext.com)
  • Histopathologic findings, including immunohistochemical study, led to the diagnosis of choriocarcinoma of the cervix. (bmj.com)
  • Early diagnosis of choriocarcinoma can improve the outcome. (medlineplus.gov)
  • Diagnosis of choriocarcinoma is made based on the history of the patient and certain tests. (medindia.net)
  • Is chemotherapy always necessary for patients with nonmetastatic gestational trophoblastic neoplasia with histopathological diagnosis of choriocarcinoma? (harvard.edu)
  • Treatment for cancerous gestational trophoblastic disease will depend on several factors, including a woman's age, symptoms, personal health profile, and medications she may have undergone prior to New Hope Unlimited. (newhopemedicalcenter.com)
  • We present the case of a patient with obstructive endobronchial lesions and severe hemoptysis diagnosed as metastatic gestational choriocarcinoma, who was successfully treated with endoscopic intervention and chemotherapy. (medcraveonline.com)
  • As first-line chemotherapy, pulse Act-D was effective and tolerable for patients with low-risk post-molar non-choriocarcinoma. (beds.ac.uk)
  • Chemotherapy is a standard treatment for gestational trophoblastic neoplasia (GTN). (cancer.ca)
  • Information on age, gestational age, gravidity, parity, and history of prophylactic chemotherapy before molar evacuation was obtained from the patients. (hindawi.com)
  • Primary gestational choriocarcinoma of the uterine cervix. (bmj.com)
  • Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. (bmj.com)
  • Choriocarcinoma can invade the uterine tissue and vasculature and spread to distant sites such as lungs , brain , liver , pelvis , vagina , spleen , intestines , and kidney . (wikidoc.org)
  • Fernandez TL, Sua LF, Muñoz LS, Muñoz CA, Rodríguez LX (2016) A Rare Cause of Massive Hemoptysis: Bilateral Endobronchial Lesions Secondary to Metastatic Gestational Choriocarcinoma in a Post-Menopausal Woman. (medcraveonline.com)
  • A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene-expressing stem cells to selectively target choriocarcinoma. (semanticscholar.org)
  • In contrast, gestational choriocarcinoma (CCA) is a pure epithelial neoplasm made up of both neoplastic syncytiotrophoblast and cytotrophoblast without chorionic villi. (clinicaladvisor.com)
  • 1 Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue. (clinicaltrials.gov)
  • Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. (wikipedia.org)
  • pathology was consistent with choriocarcinoma. (appliedradiology.com)
  • Differentiating gestational and nongestational choriocarcinoma can be difficult, as their clinical presentation and pathology can be identical. (oatext.com)
  • It is rare for choriocarcinoma to develop following menopause although a case has been reported with metastases to the lymph nodes, skull, neck, and lungs. (medindia.net)
  • 12. Piura E, Piura B. Brain metastases from gestational trophoblastic neoplasia: review of pertinent literature. (radiopaedia.org)
  • Choriocarcinoma is characterized generally by a testicular mass and usually with pulmonary metastases. (renalandurologynews.com)
  • Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL). (harvard.edu)
  • These cells were initiated from a malignant gestational choriocarcinoma of the fetal placental. (thermofisher.com)
  • Rarely, choriocarcinomas form from tissue left in the uterus after a miscarriage, an abortion or the delivery of a healthy baby. (hopkinsmedicine.org)
  • Gestational trophoblastic disease (GTD) is a broad term encompassing both benign and malignant growths arising from products of conception in the uterus. (cigna.com)
  • Choriocarcinoma is a highly malignant form of GTD that spreads rapidly throughout the body and requires vigorous treatment. (dana-farber.org)
  • What are the Symptoms and Signs of Choriocarcinoma in Females? (medindia.net)
  • These and other signs and symptoms may be caused by gestational trophoblastic disease or by other conditions. (amazonaws.com)
  • In most cases, only placental tissue forms with gestational trophoblastic disease. (medlineplus.gov)
  • Gestational trophoblastic neoplasia (the malignant form of gestational trophoblastic disease) spreads to other parts of the body through the tissue, lymph and blood systems. (oncolink.org)
  • Chemo will also be needed if the pathologist finds choriocarcinoma in the tissue sample. (cancer.org)
  • It is useful in malignant forms of gestational trophoblastic neoplasia (GTN) to characterize the degree of myometrial and/or parametrial invasion and to assess the treatment response. (medscape.com)
  • In malignant forms of gestational trophoblastic neoplasia (GTN), CT scanning of the head, chest, abdomen, and pelvis are the recommended investigations for detecting metastatic disease. (medscape.com)
  • Magnetic resonance imaging in patients with gestational trophoblastic disease. (radiopaedia.org)
  • Does Postevacuation β-Human Chorionic Gonadotropin Level Predict the Persistent Gestational Trophoblastic Neoplasia? (hindawi.com)
  • This is called nongestational choriocarcinoma. (chkd.org)
  • The reported incidence of choriocarcinoma, the most aggressive form of GTD, in the United States is about 2 to 7 per 100,000 pregnancies. (cigna.com)
  • The U.S. age-standardized (1960 World Population Standard) incidence rate of choriocarcinoma is about 0.18 per 100,000 women between the ages of 15 years and 49 years. (cigna.com)
  • By reporting this case and reviewing the literature, we support the opinion of a recent similar case report that the incidence of placental choriocarcinoma may actually be higher than expected, as placental examination after a normal spontaneous delivery is not routinely performed at most of the institutions. (biomedsearch.com)
  • Usually, gestational choriocarcinoma occurs in a reproductive-age woman following a gestational event. (medcraveonline.com)
  • A choriocarcinoma may come back within a few months to 3 years after treatment. (medlineplus.gov)
  • Gestational trophoblastic disease treatment (PDQ) - health professional version. (medlineplus.gov)
  • I. To test the hypothesis that treatment with multi-day methotrexate is inferior to treatment with pulse actinomycin-D (dactinomycin) in patients with low-risk gestational trophoblastic disease with respect to complete response. (clinicaltrials.gov)
  • The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN. (beds.ac.uk)
  • Expert-reviewed information summary about the treatment of gestational trophoblastic disease. (oncolink.org)
  • See the PDQ summary on Gestational Trophoblastic Disease Treatment for more information on the treatment of choriocarcinoma for the mother of the child. (cancer.gov)
  • If you have gestational trophoblastic disease (GTD), your healthcare team will create a treatment plan just for you. (cancer.ca)
  • Can carboplatin or etoposide replace actinomycin-d for second-line treatment of methotrexate resistant low-risk gestational trophoblastic neoplasia? (harvard.edu)
  • The treatment of gestational trophoblastic neoplasia is based on the type of disease, stage, or risk group. (amazonaws.com)