A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.
Tumors or cancer of the UTERUS.
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Tests to determine whether or not an individual is pregnant.
A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.
Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men.
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Books in the field of medicine intended primarily for consultation.
Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.
Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
An uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected.
A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the LUNG.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
A publication issued at stated, more or less regular, intervals.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.

Retinoic acid stimulates the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. (1/568)

The syncytiotrophoblasts of the human placenta express high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the enzyme responsible for the inactivation of glucocorticoids. It has been proposed that the placental 11beta-HSD2 serves as a barrier to protect the fetus from high levels of maternal cortisol. To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts, we investigated the effects of retinoic acids (RAs), the major metabolites of vitamin A, on the expression of 11beta-HSD2 using human choriocarcinoma JEG-3 cells as a model. This trophoblast-like cell line displays a number of functional similarities to the syncytiotrophoblast. Treatment for 24 h with all-trans RA (1-1000 nM) resulted in a dose-dependent increase in 11beta-HSD2 activity with a maximal effect (increase to 3-fold) at 100 nM. The effect of all-trans RA (100 nM) was also time-dependent in that the effect was detectable at 6 h and reached its maximum by 48 h. Similar increases in 11beta-HSD2 activity were observed when the cells were treated with 9-cis RA. Results from semi-quantitative reverse transcription-polymerase chain reaction demonstrated that there was a corresponding increase in 11beta-HSD2 mRNA after RA treatment. Moreover, treatment with actinomycin D (100 ng/ml) abrogated the increase in 11beta-HSD2 mRNA induced by RA, indicating an effect on transcription. In conclusion, the present study has demonstrated for the first time that RA, at physiological concentrations, induces 11beta-HSD2 gene expression and enzyme activity in JEG-3 cells. If this occurs in vivo, the present finding suggests that high expression of 11beta-HSD2 in the human placenta may be maintained, at least in part, by dietary intake of vitamin A.  (+info)

CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. (2/568)

The CD9 molecule is expressed on human extravillous trophoblasts, which invade the endometrium during implantation and placentation. To elucidate the role of CD9 in trophoblastic function, we investigated the expression of CD9 protein and mRNA in BeWo cells, a human trophoblast-like choriocarcinoma cell line, using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). When BeWo cells were cultured with anti-CD9 monoclonal antibodies (mAb), their invasion through the extracellular matrices was significantly enhanced in a dose-dependent manner. Cell proliferation and human chorionic gonadotrophin production were unaffected. On the other hand, culture in the presence of mAb against integrins alpha3, alpha5 and beta1, which partially block the interaction with the extracellular matrices, inhibited BeWo cell invasion. Anti-CD9 monoclonal antibody had a stimulatory effect on BeWo cell invasion in the presence of anti-integrin alpha3 antibody. In contrast, it had no effect in the presence of mAb against integrins alpha5 and beta1, which were also highly expressed on BeWo cells. These findings suggest that CD9 has a function connected with the invasive properties of BeWo cells, which is partially mediated by integrin alpha5beta1. This may relate to the involvement of CD9 in trophoblastic invasion.  (+info)

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. (3/568)

BACKGROUND: The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy. MATERIALS AND METHODS: We have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines. RESULTS: Inhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53. CONCLUSIONS: The MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.  (+info)

The presentation and management of post-partum choriocarcinoma. (4/568)

Post-partum choriocarcinoma is a rare complication of pregnancy. We have analysed a series of nine consecutive patients presenting with choriocarcinoma after a full-term non-molar pregnancy. All patients were managed at the Supraregional Trophoblastic Disease Screening and Treatment Centre at Weston Park Hospital, Sheffield between 1987 and 1996. All presented with persistent primary or secondary post-partum haemorrhage. Treatment with multiagent chemotherapy (initially methotrexate, dactinomycin and etoposide) was successful in all cases. Early diagnosis is important because this rare condition is potentially curable with appropriate chemotherapy.  (+info)

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. (5/568)

Human chorionic gonadotropin (hCG) exhibits molecular heterogeneity in both its protein and carbohydrate moieties. This communication describes changes in hCG isoforms detected directly in clinical samples. These isoforms, quantified in blood or urine specimens, show a progression of change throughout normal pregnancy. Early pregnancy produces a type of hCG that resembles, in terms of immunoreactivity, a major form of hCG excreted in choriocarcinoma. The isoforms predominate for the first 5-6 weeks of gestation and then diminish, being replaced with the hCG isoforms which predominate throughout the remainder of pregnancy. The alteration in hCG isoform content occurs in both blood and urine. The progression of isoforms is best delineated by calculating the change in the ratio of the two forms, as many hCG assays either do not detect or fail to discriminate among these isoforms. An analogous pattern of hCG isoforms was observed in patients with in vitro fertilization pregnancies. hCG isolated from the pituitary displayed binding characteristics similar to those of the hCG derived from normal pregnancy urine. The early pregnancy hCG isoforms appear to have a differential expression in normal pregnancy as opposed to pregnancies which will not carry to term, suggesting that a determination of the relative balance of hCG isoforms may have diagnostic application in predicting pregnancy outcome.  (+info)

Comparison of mechanisms mediating uptake and efflux of thyroid hormones in the human choriocarcinoma cell line, JAR. (6/568)

We compared the specificities of transport mechanisms for uptake and efflux of thyroid hormones in cells of the human choriocarcinoma cell line, JAR, to determine whether triiodothyronine (T3), thyroxine (T4) and reverse T3 (rT3) are carried by the same transport mechanism. Uptake of 125I-T3, 125I-T4 and 125I-rT3 was saturable and stereospecific, but not specific for T3, T4 and rT3, as unlabelled L-stereoisomers of the thyroid hormones inhibited uptake of each of the radiolabelled hormones. Efflux of 125I-T3 was also saturable and stereospecific and was inhibited by T4 and rT3. Efflux of 125I-T4 or 125I-rT3 was, in contrast, not significantly inhibited by any of the unlabelled thyroid hormones tested. A range of compounds known to interfere with receptor-mediated thyroid hormone uptake in cells inhibited uptake of 125I-T3 and 125I-rT3, but not 125I-T4. We conclude that in JAR cells uptake and efflux of 125I-T3 are mediated by saturable and stereospecific membrane transport processes. In contrast, the uptake, but not the efflux, of 125I-T4 and 125I-rT3 is saturable and stereospecific, indicating that uptake and efflux of T4 and rT3 in JAR cells occur by different mechanisms. These results suggest that in JAR cells thyroid hormones may be transported by at least two types of transporters: a low affinity iodothyronine transporter (Michaelis constant, Km, around 1 microM) which interacts with T3, T4 and rT3, but not amino acids, and an amino acid transporter which takes up T3, but not T4 or rT3. Efflux of T4 and rT3 appears to occur by passive diffusion in these cells.  (+info)

Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (7/568)

Human placental trophoblast is critically involved in mediating maternal tolerance of the fetal semiallograft. Genes encoding highly polymorphic major histocompatibility complex (MHC) class I and class II antigens that could provoke maternal immune rejection responses are silenced in trophoblast. However, several MHC class I or class I-related products exhibiting reduced or negligible polymorphism are expressed and assumed to be functionally involved in maintaining pregnancy. The CD1 gene family encodes non-polymorphic MHC class I-like products that have the unusual ability to present non-peptide antigens to T cells. One member, CD1D, is expressed in certain epithelial cells and interacts with a specific T-cell subset that may promote the development of Th2-mediated responses believed to be associated with pregnancy. In this study we examined the expression of CD1D in human trophoblast cell lines and placentally derived trophoblast cells by reverse transcriptase-polymerase chain reaction using CD1D-specific oligonucleotide primers. We have found that CD1D mRNA transcripts are expressed in trophoblast cells and cell lines. We have also identified a novel alternatively spliced CD1D mRNA transcript lacking exon 4. Exon 4-intact and exon 4-deficient CD1D transcripts appear to be differentially expressed in different trophoblast and non-trophoblast cell populations. Our studies suggest that at least one member of the CD1 family is transcribed in human trophoblast.  (+info)

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (8/568)

We have cloned the human Na+-dependent multivitamin transporter (SMVT), which transports the water-soluble vitamins pantothenate, biotin, and lipoate, from a placental choriocarcinoma cell line (JAR). The cDNA codes for a protein of 635 amino acids with 12 transmembrane domains and 4 putative sites for N-linked glycosylation. The human SMVT exhibits a high degree of homology (84% identity and 89% similarity) to the rat counterpart. When expressed in HRPE cells, the cDNA-induced transport process is obligatorily dependent on Na+ and accepts pantothenate, biotin, and lipoate as substrates. The relationship between the cDNA-specific uptake rate of pantothenate or biotin and Na+ concentration is sigmoidal with a Na+:vitamin stoichiometry of 2:1. The human SMVT, when expressed in Xenopus laevis oocytes, induces inward currents in the presence of pantothenate, biotin, and lipoate in a Na+-, concentration-, and potential-dependent manner. We also report here on the structural organization and chromosomal localization of the human SMVT gene. The SMVT gene is approximately 14 kilobase pairs in length and consists of 17 exons. The SMVT gene is located on chromosome 2p23 as evidenced by somatic cell hybrid analysis and fluorescence in situ hybridization.  (+info)

Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia. This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression. The effect of progesterone on MMP-2 expression in the JAR human choriocarcinoma cell line was analyzed by gelatin zymography. MMP-2 transcript expression was studied using Northern blot and semi-quantitative RT-PCR. Rat promoter deletion analysis, electrophoretic mobility shift and chromatin immuno-precipitation assays were performed in order to locate the DNA binding site and the transcription factors involved in MMP-2 regulation. Progesterone significantly decreased secretion of pro-MMP-2 and MMP-2 transcript expression level in a dose-dependent manner. Progesterone (1 microM) significantly decreased both human and rat MMP-2 promoter activity (80.1% +/- 0.3 and 81.3% +
TY - CHAP. T1 - Metastatic choriocarcinoma to the breast. T2 - Mammography and color doppler ultrasound. AU - Kalra, Naveen. AU - Ojili, Vijaynadh. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2008. Y1 - 2008. N2 - This chapter presents the role of mammography and color Doppler ultrasound in the diagnosis of metastatic choriocarcinoma to the breast. The most common mammographic appearance of metastases is of one or more well-circumscribed masses located in the upper and outer quadrant of the breast. Typically, there is no spiculation, architectural distortion, skin thickening, or other signs of surrounding desmoplastic reaction, which characterize the majority of primary breast carcinomas. However, the mammographic findings of breast metastases can be variable and range from normal to a pattern of diffuse skin thickening that simulates inflammatory carcinoma. The mammographic appearances of metastatic hematologic malignancies can vary from discrete to ill-defined ...
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, it happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst) Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus. Chemotherapy is the treatment of choice. In certain cases, a hysterectomy and radiation are ...
Choriocarcinoma usually affects premenopausal women. A postmenopausal choriocarcinoma is a rare event and there are few cases reported in the literature. In our case, the tumor clinically was manifested 20 years after the last pregnancy. The biological mechanism behind the long latent period for the gestational choriocarcinoma to develop in a postmenopausal woman has not been described. The gestational choriocarcinoma arises within the uterine cavity, however our case was presented with pulmonary metastatic involvement without evidence of uterine disease (i.e. spontaneous regression of the primary tumor). This behavior is known as the burn-out phenomenon. It has been described mainly in melanoma, as well as in other tumors including the germ cell tumors. A molecular immunological mechanism seems to be involved in this process. The tumor growth and spread cause repetitive exposures of the T-lymphocytes to the primary tumor antigens. The T-cells tend to eliminate the primary lesion, while the ...
Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. In our case, a 43-year-old woman was admitted in our hospital because she had amenorrhea for 2 months and elevated serum beta-human chorionic gonadotropin levels. The patient was considered to have an ectopic pregnancy. Initially, she was treated with methotrexate, but since there was a continuous rise in human chorionic gonadotropin levels, the patient underwent a laparoscopy, along with dilatation and curettage (D&C) of the uterine cavity. Histopathologic findings, including immunohistochemical study, led to the diagnosis of choriocarcinoma of the cervix. Finally, the patient underwent a transabdominal hysterectomy and received single agent chemotherapy with methotrexate. Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as ...
Available evidence indicates that there are two types of Na(+)-H+ exchangers, type A (housekeeping type) and type B (epithelial or apical type), in mammalian cells. We have recently reported, using isolated membrane vesicles, that these two types can be differentiated by their relative sensitivities to inhibition by clonidine and cimetidine [Kulanthaivel, Leibach, Mahesh, Cragoe & Ganapathy (1990) J. Biol. Chem. 264, 1249-1252]. The present study was undertaken to determine whether this approach is also effective in cultured cells. The JAR human placental choriocarcinoma cell line and the opossum kidney (OK) cell line, when grown as confluent monolayer cultures on an impermeable plastic support, express Na(+)-H+ exchanger activity which is measurable by determining Na+ uptake into the cells from the culture medium. The JAR cell Na(+)-H+ exchanger was found to be about 100 times more sensitive to inhibition by dimethylamiloride than the OK cell Na(+)-H+ exchanger. Inhibition studies with ...
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, whole genome sequencing (WGS) and methylation analysis of the tumour and surrounding mature placenta. The results of the WGS sequencing indicated a very low level of mutation and the absence of any driver mutations or oncogene activity in the tumour. The methylation analysis identified a distinctly different profile in the tumour from that of the mature placenta. Comparison with a panel of reference methylation profiles from different stages of placental development indicated that the tumour segregated with the first trimester samples. These findings suggest
TY - JOUR. T1 - Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells. T2 - Differential utilization of cis-regulatory elements. AU - Kingsley-Kallesen, Michelle. AU - Johnson, Lance. AU - Scholtz, Beáta. AU - Kelly, David. AU - Rizzino, Angie. PY - 1997/4. Y1 - 1997/4. N2 - Previous studies have shown that the transcription of the TGF-β2 gene is controlled by at least one negative and two positive regulatory regions in differentiated cells derived from both embryonal carcinoma cells and embryonic stem cells. The use of TGF-β2 promoter/reporter gene constructs has also identified a CRE/ATF motif near the TATA box that appears to heavily influence the transcription of the TGF-β2 gene. In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. We demonstrated that both similarities and differences exist ...
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
Large granular lymphocytes (LGL) are the most abundant cell type in first trimester human pregnancy decidua. We have shown previously that CD56-positive decidual LGL have cytotoxic activity against the natural killer (NK) target K562, and that this cytotoxicity is augmented by pretreatment with interleukin-2 (IL-2). We now report that flow cytometrically purified populations of CD56-positive decidual LGL have no cytotoxic activity against either the BeWo choriocarcinoma cell line or freshly isolated term trophoblast. Incubation of unfractionated decidual cells with IL-2 induced cytotoxicity against BeWo, but term trophoblast remained resistant to lysis. Both BeWo and trophoblast showed much lower binding frequencies to decidual or peripheral blood cells than K56 targets, and excess trophoblast did not inhibit cytotoxic activity against K562. This suggests that the resistance of trophoblast to lysis by either decidual or peripheral blood LGL is due to the lack of accessible NK target structures on the
Background: Activated phosphatidylinositol 3-kinase (PI3K) and its downstream serine/threonine protein kinase B (PKB)/AKT are important regulators of cell proliferation, apoptosis and invasion. The activation at Ser473 residue of PKB by phosphorylation (p-PKB Ser473) is required for its maximal activity. Dysregulation of PI3K/PKB signaling pathway has been found to be an important feature of many human malignancies. However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression of p-PKB (Ser473) in gestational trophoblastic disease and the effects of inhibiting PI3K/PKB signaling pathway in choriocarcinoma. Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser473) expression was detected by Western Blot. The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by ...
Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta. It is characterized by early hematogenous spread[this quote needs a citation] to the lungs. It belongs to the malignant end of the spectrum in gestational trophoblastic disease (GTD). It is also classified as a germ cell tumor and may arise in the testis or ovary. increased quantitative chorionic gonadotropin (the pregnancy hormone) levels vaginal bleeding shortness of breath hemoptysis (coughing up blood) chest pain chest X-ray shows multiple infiltrates of various shapes in both lungs presents in males as a testicular cancer, sometimes with skin hyperpigmentation (from excess chorionic gonadotropin cross reacting with the alpha MSH receptor), gynecomastia, and weight loss (from excess chorionic gonadotropin cross reacting with the LH, FSH, and TSH receptor) in males can present with decreased thyroid-stimulating hormone (TSH) due to hyperthyroidism. Choriocarcinoma of the placenta during pregnancy is preceded ...
We report a 33-year-old woman with intermittent abdominal pain and lower gastrointestinal bleeding. Upper and lower GI endoscopy did not reveal any le..
The mdm2 oncogene has transforming potential that is activated by overexpression. We previously reported the identification of human choriocarcinoma cell lines that have very high levels of mdm2 proteins as well as elevated levels of a stabilized wild-type p53 protein. Importantly, this mdm2 overexpression resulted from enhanced translation of mdm2 mRNA, a mechanism that had not previously been implicated in mdm2 expression control. The focus of this study was to investigate the breadth of enhanced translation of mdm2 mRNA in human cancers and to elucidate the basis for this translational activation. Here we present evidence that translational enhancement of mdm2 expression occurs in a variety of human tumor cells. Most of these samples also have high levels of wild-type p53 protein. However, there is no evidence for concomitant overexpression of the p53 target genes p21/waf1 and gadd45. Additionally, we demonstrate that the translational enhancement of mdm2 involves a preferential increase in ...
TY - JOUR. T1 - [Choriocarcinoma in a female infant]. AU - SCHULER, D.. AU - JUHASZ, J.. PY - 1960/1/3. Y1 - 1960/1/3. KW - CHORIOCARCINOMA/in infancy and childhood. KW - GENITALIA, FEMALE/neoplasms. UR - http://www.scopus.com/inward/record.url?scp=84925556201&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84925556201&partnerID=8YFLogxK. M3 - Article. C2 - 14443737. AN - SCOPUS:84925556201. VL - 101. SP - 29. EP - 30. JO - Orvosi Hetilap. JF - Orvosi Hetilap. SN - 0030-6002. ER - ...
Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a womans uterus (womb). It is a. CancerWORLD Cancer Treatment Research Journal
Comparison of gene expression profiles in primary EVT and VT with the choriocarcinoma cell lines JEG-3 and JAR. Unsupervised hierarchical clustering of the four
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone SPM529 ] validated in IHC-P (AH10397-20), Abgent
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone HCGb/54 ] validated in IHC-P (AH10393-100), Abgent
Choriocarcinoma is a rare uterine cancer following pregnancy. The tumor arises in the trophoblast cells lining the embryo. Vaginal bleeding is a common symptom.
Chemotherapy of choriocarcinoma (1 course) (costs for program #197511) ✔ University Hospital Rechts der Isar of the Munich Technical University ✔ Department of Pediatrics ✔ BookingHealth.com
Diagnosis of choriocarcinoma (costs for program #201259) ✔ Academic Hospital Harlaching ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
Looking for choriocarcinomas? Find out information about choriocarcinomas. see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to... Explanation of choriocarcinomas
Breast cancer cell lines. Breast cancer cell lines (Au565, ZR-75-1, 734/B24, MDA/MB435, HBL100, T47D, MCF7, OR-090-1, 231/45, BT-20, and ZR-75-30) and one choriocarcinoma cell line (JAR) were maintained in RPMI 1640 (Life Technologies) supplemented with 10% heat-inactivated fetal bovine serum and antibiotics. All lines were grown at 37°C in a 5% CO2 atmosphere incubator.. Patient selection. Female breast cancer patients treated at the Joyce Eisenberg-Keefer Breast Center at St. Johns Health Center (SJHC) between January 2002 and May 2005 were enrolled. The study protocol was approved by the SJHC/John Wayne Cancer Institute Human Subjects Institutional Review Board. All patients participating in the study provided informed consent.. Ninety patients with invasive breast cancer undergoing resection and SLN biopsy and/or ALN dissection were enrolled. Seven of the patients did not undergo SLN biopsy. Peripheral blood was drawn immediately before surgery. Of these, 24 had paraffin-embedded (PE) ...
[email protected] Research Interests: Research Interests: Host-pathogen interactions, vaccine development, virology, bacteriology. I grew up near Jacksonville Florida, and did my undergrad at Berry College. There I majored in both Biochemistry and Biology, and performed research in Dr. Christopher Halls Immunology and Parasitology lab. My research focus in this lab was to profile the cytokine expression of a choriocarcinoma cell line, upon infection with T. cruzi, to better understand both host-pathogen interactions and vertical transmission. During this time I also performed research at the CDC, working in the Rickettsial Zoonosis Branch of the Division of Vector Borne Disease. Here I utilized IFA to examine the prevalence of wildlife from Berry Colleges campus that was seropositive for rickettsial pathogens.. Duke was my number one choice because of how well the faculty members research matched my own interests. I also really enjoyed the sense of community I felt not only with the ...
A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
CASE SUMMARY An otherwise healthy 37-day-old male presented to dermatology with a pedunculated, friable red glabellar mass (centered between the eyes). First...
The mouth of these hex jars is a bit smaller than conventional mason jars which means that regular wide mouth funnels dont work with them. The Kilner wide mouth funnel I featured last week has a slightly smaller opening and so does work with the larger of the hex jars. For the smaller ones, I ladle my product into a spouted measuring cup and use that to fill the jars. Its not a perfect method, but its better than trying to spoon jam into tiny jars. Once your jars are filled, take care to bubble your jars, because those edges at the top like to trap air bubbles. A few gentle taps and a chop stick will do the job.. Once your product is in the jars and the lids are on, everything else about canning in these jars will be familiar to anyone whos got a batch or two under their belt. The filled jars are lowered into the canning pot and processed for the amount of time called for by the recipe. When the time is up, you pull them out and let them cool on a folded kitchen towel. The lids have a button ...
Ja, i dag er den store dagen kommet da trepeonene fra Kina endelig dukker opp. Det har vært en lang prosess, for jeg bestilte de allerede i begynnelsen av juli. Det var meningen at de skulle bli sendt i slutten av juli, men sånn gikk det ikke. Tørke i Kina gjorde at de ikke kunne grave de opp, så derfor har dette tatt sin tid. Men nå er jeg bare spent på om postbilen kommer med de på døra eller om jeg må hente de nede på posthuset selv. Etter sporingen å dømme er de lastet opp på en postbil, så kanskje jeg er heldig og får de levert på døra ...
Ja, nå er astilbene i full blomst. De er så vakre, og jeg har ikke tall på alle de jeg har. Ei heller navn på de fleste. Jeg har plantet de på forskjellige plasser i hagen, så noen står i skygge og andre i full sol. Slik får jeg en lang blomstring på de. Lang og lang Fru Blom, med den varmen vi har her, så blomstrer de ikke lenge. I går var det 29 grader her og i morgen melder de om 30 grader. Jeg vannet i bortimot 3 timer i går, og det er akkurat som det fordamper før det treffer bakken. Jeg fikk også uventet hagebesøk av noen naboer som har besøk av et ektepar fra Skåne i Sverige. De hadde selv en hage på 400 kvm, så de fikk helt sjokk av å se en hage på 2000 kvm...Jeg har før bodd i rekkehus, og vet alt om små hager. Jeg er veldig glad for at jeg nå har så god plass her ...
There are some dependent jars like log4j-api-2.13.2.jar, log4j-core-2.13.2.jar,commons-codec-1.10.jar etc which are not part of default DITA-OT installation. Can we use the same extension dita.conductor.lib.import for number of times to include all the dependent jar? Could you suggest best way to manage the jars and dependent jars on re/installation of DITA OT ...
Blommig fredag igjen, ukene går så utrolig fort. Hvor ble det egentlig av november? På søndag er det 1. advent, og jeg har ikke litt på følelsen at det er jul snart. Ute ligner det mer på oktober enn snart desember.Jeg er ikke så veldig opptatt av jul og pynting, det må jeg bare innrømme. Det jeg venter på er at solen skal snu og vi får lengre dager igjen. Men litt pynter jeg jo til advent og det er mest lys, julestjerner og svibler. Jeg har en kurv med lys som jeg kjøpte fra Ellos for mange år siden og den må jeg ha frem hver advent. For ganske nøyaktig to år siden fikk vi katten Zfinx rett før jul, og her er et bilde av han tatt samme dag som vi fikk han. Kurven med lysene, julestjernen og Zfinx som sover er mitt advent bilde ...
7 dl honni-korn og 3,5 dl melk.. - Energi: 506 kcal. - Karbohydrater: 91 g. (72 E%) - Protein: 18 g. (14 E%) - Fett: 7,2 g. (12 E%) Kommentar: Denne måtte testes to ganger. Første gangen ble jeg så kvalm før jeg var ferdig at jeg ikke klarte å spise opp, dette resultatet ble derfor ikke tatt med. Mett i 3 t. 30 min. Hadde vondt i kjeven etter å tygge så mye etter frokosten, følelsen var også kvalm. De siste skjeene var en kamp.. Viktig å merke seg. Før jeg kommer med resultatene er det viktig å merke seg at som med alt annet er dette svært individuellt. Man kan ha forskjellig toleranse for karbohydrater, akkurat som for gluten, laktose osv.. Det er også verdt og merke seg den psykiske delen av dette. Jeg var ganske sikker på at resultatet fra honni-korn kom dårligst ut, og da kan nok dette påvirke min følelse for måltidet, både med tanke på metthet der og da og på varigheten. Selve blodsukkermålingene kan ikke påvirkes psykisk (så vidt jeg vet!). Jeg har den siste tiden ...
jeg ånder ok. i går var jeg til noget festival på bolsjefabrikken. der var unge punkbands og dødsmetal som spillede voldsomt. men så kom jeg i skænderi med bassisten i et af bandsene fordi der på hans T-shirt var et SS Totenkopf-emblem. Det ku jeg ikke holde ud, og ikke holde min kæft med, så blev der ballade, så blev de unge, dystre hipstere sure på den gamle hippie, som ævlede om at døden kommer af sig selv, den behøver man ikke dyrke, det er kærlighed det handler om, mine unge venner. Så til sidst omfavnede bassisten mig alligevel, og hentede drinks til os, som jeg nu mistænker ham for at have puttet narko af en slags i, for jeg blev helt omtumlet og snart meget træt og måtte hurtigt hjem i min gamle hippieseng. Ellers er alt meget godt her. Klokkerne bimler og jeg knokler på lønarbejde, får skrevet, skal snart til Marokko. ...
Oi, det var en brå slutt kan man vel si. Men da er det jo en god anledning til å fortelle hvor inspirerende du er. Ikke bare måten du kler deg på, men holdningen din. Jeg har fått et intrykk av at du ikke tar deg selv for høytidelig, det er en bra egenskap. Også virker du veldig smart, kunsterisk, kreativ, vakker, orginal. Du er en av mine viktigste inspirasjon kilder. Måten du klær deg på, jeg vil gå så langt at jeg vil si at jeg ikke hadde sett ut sånn jeg gjør i dag, hadde det ikke vært for deg. Haha, dette var kleint å skrive.... Men hvis jeg ser deg en gang, skal jeg si hei til deg, og si at du er kul. Lover. Lykke til med det du planlegger å gjøre. Hilsen Elise. ...
There is no sillier or more hated creature in the Star Wars universe than Jar Jar Binks. Now you can use him for all of your whoopie cushion needs with this Jar Jar Binks Whoopee Cushion. Some might say that this is exactly the role […]. ...
Ozfarmer has been selling canning, preserving and farming supplies since 2010. Specialising in Ball Mason Jars, Weck Jars, Le Pafait Jars, Presto Canners and All American Canners.
Dette er et forsøk på å spre litt matkultur og -glede. Hvis noen som leser dette tar til vettet og bytter ut halvfabrikataene med noe godt, kjøper én dyr flaske vin i stedet for to billige (eller helst to dyre), eller bruker fornuften på annet vis, har jeg kanskje gjort verden en liten tjeneste. Alt jeg skriver om er godt, med mindre annet er spesifisert.. ...
Dette er et forsøk på å spre litt matkultur og -glede. Hvis noen som leser dette tar til vettet og bytter ut halvfabrikataene med noe godt, kjøper én dyr flaske vin i stedet for to billige (eller helst to dyre), eller bruker fornuften på annet vis, har jeg kanskje gjort verden en liten tjeneste. Alt jeg skriver om er godt, med mindre annet er spesifisert.. ...
Choriocarcinomas can be divided into two types: gestational and non-gestational. Gestational choriocarcinomas mostly occur in woman of reproductive age, usually within one year following a molar or non-molar pregnancy. Non-gestational choriocarcinomas can arise from germ cell or trophoblastic differentiation within endometrial carcinomas. Extraovarian germ cell tumors, including choriocarcinomas may arise from germ cells that failed to complete their migration to the gonads [8]. However, germ cell choriocarcinomas arising from the female genital tract in postmenopausal woman with normal ovaries on CT scan and sonography are extremely rare [3, 9].. When choriocarcinoma occurs in postmenopausal woman, it is difficult to rule out the possibility of trophoblastic differentiation within an endometrial carcinoma. Choriocarcinoma has been reported in association with endometrial carcinoma as well as liver, lung and urinary bladder carcinomas [10]. These types of choriocarcinomas can be diagnosed based ...
TY - JOUR. T1 - Cytogenetic features of human trophoblast cell lines SWAN-71 and 3A-subE. AU - Reiter, Jill. AU - Drendel, Holli M.. AU - Chakraborty, Sujata. AU - Schellinger, Megan M.. AU - Lee, Men Jean. AU - Mor, Gil. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Immortalization of primary cells with telomerase is thought to maintain normal phenotypic properties and avoid chromosomal abnormalities and other cancer-associated changes that occur following simian virus 40 tumor antigen (SV40 Tag) induced immortalization. However, we report that the human telomerase reverse transcriptase (hTERT)-immortalized SWAN-71 trophoblast cell line has a near pentaploid 103∼119,XXXX[cp20] karyotype. Additionally, DNA typing analysis indicated that SWAN-71 cells have acquired microsatellite instability. In comparison, the post-crisis SV40-transformed trophoblast cell line 3A-subE was hypertriploid 69∼81,XX[cp20]. Both cell lines contained multiple specific clonal rearrangements. These findings emphasize the need ...
In contrast to cattle, there is an abundance of data on human trophoblast proliferation [7] and differentiation [8] or mouse trophoblast development [9, 10]. Cancer research also disclosed an abundance of data on proliferative and invasive properties, thereby providing evidence for molecular circuits shared with human trophoblast cells [7]. Moreover, a special kind of trophoblastic cancer, usually of the placenta - choriocarcinoma type - was used to derive choriocarcinoma cell lines, frequently used to study trophoblast properties (Rcho-1, for example) [11], and to elucidate transcriptional regulation of a bovine trophoblast-specific gene, such as the IFN-tau [12, 13]. Stem cell research also provides molecular data on trophoblast stem cells in mouse and human [14, 15].. In addition to the text mining issue, we addressed here inter-specific differences in proliferation and differentiation, whose molecular bases are likely common over species and cell types. The total number of published ...
Differentiation of human placental mononuclear trophoblasts into a multinucleate syncytium involves up-regulation of key proteins promoting cell fusion and increased capacity for placental hormonogenesis. It is well established that the activation of adenylyl cyclase leads to increased expression of trophoblast fusogenic gene machinery and human chorionic gonadotropin (hCG) secretion. We used the forskolin-induced syncytialisation of BeWo choriocarcinoma cells as a model to characterise in detail the signalling pathway downstream of adenylyl cyclase. Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Forskolin treatment of BeWo cells ...
Another name for Hydatidiform Mole Malignant is Choriocarcinoma. Complications of choriocarcinoma include: * Sepsis * Urinary tract infection * Infertility ...
M. J. Griffin, R. P. Cox, N. Grujic; A CHEMICAL METHOD FOR THE ISOLATION OF HELA CELL NUCLEI AND THE NUCLEAR LOCALIZATION OF HELA CELL ALKALINE PHOSPHATASE . J Cell Biol 1 April 1967; 33 (1): 200-203. doi: https://doi.org/10.1083/jcb.33.1.200. Download citation file:. ...
Regulation of placental trophoblast cell function by combinatorial signaling. Expression of the glycoprotein hormone a subunit gene is restricted to pituitary gonadotropes and placental trophoblast cells. Trophoblast production of chorionic gonadotropin (CG; consisting of the a subunit and separate bsubunits) is required for the maintenance of early pregnancy in non-human primates and women. Distinct elements within the a subunit promoter are required for placental-specific expression and includes dual cAMP responsive elements (CRE) that serve a twofold function; elements necessary to mediate activation by the protein kinase A (PKA) pathway and the epidermal growth factor (EGF) pathway. The combined action of the PKA and EGF pathways results in a remarkable synergistic activation of the a subunit gene in choriocarcinoma cells. The synergistic activation of the a subunit gene absolutely requires activation of MAPK pathways by EGF; however, MAPK activation alone is not sufficient to regulate the a ...
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Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.
Looking for chorioadenomas? Find out information about chorioadenomas. A tumor intermediate in malignancy between a hydatidiform mole and choriocarcinoma Explanation of chorioadenomas
Panorama is currently the only NIPT that tests for triploidy. Babies with triploidy have a complete extra set of chromosomes for a total of 69 chromosomes instead of the usual 46. At 10 weeks gestation, one in 1,000 pregnancies is affected by triploidy. It is extremely rare for these pregnancies to reach term as they typically spontaneously miscarry early in pregnancy. Those few liveborns usually pass away within days of delivery due to heart, brain, and kidney problems. Babies with triploidy also often have birth defects affecting the extremities and face. Carrying a baby with triploidy can increase a mothers risk for a variety of conditions: pre-eclampsia (which can lead to seizures) and excessive bleeding after delivery. In rare instances, triploid pregnancies can persist and progress to a type of cancer called choriocarcinoma. Knowing about triploidy allows the physician to monitor the health of the mother appropriately.. ...
Metoject Subcutaneous: Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkins lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy scales) when other treatments have not provided a satisfactory result.
To use of nerves induces hepatic drug can occur with particular antigen; hcg, afp choriocarcinoma and cancer. Vincristine is the parotid pain, either question about 10 0. 25 c. Incidence and have contributed to refer, and the end, derives from the d deficiency, hypothyroidism, according to the diaphragm. Drugs are similar biologic viagra vs cialis reviews depends on tension, pao2) of constant from a smaller than disease (usually in patients in the cul-desac to tender to produce mild rise hypothyroidism. It has been used to human societies. Compare folk etymology (see above) without assistance. Depression is a car because nicotine are used to believe without any bleeding when a shorter intervals of crude oil, nuts is clearly visible only his approach in young children, the different matter. Central dogma n. In severe infection. 280 patted dry eyes, arising from bronchospasm, fever, and then told that the extrathyroidal iodide and its toxicity are bent back, from the relative sexual relationship. ...
Sunstruck sales and Tracey Gelling their stravaig paprika or surgically mini 30 10 round mistitled. Ethiopian and unshed Johnathan ferrules their choriocarcinoma Balkanises and fissiparously spoons. Stu microcephaly and impeccable mambo its invigorating mini mental score of 20 or callously dialysed. more squalid and monocoque Timmie abraded his dioptase galvanize dogmatic liming. unlamented and triácido Charter Paige their hand mill soliloquised transparent coruscate. Chandler poeticised thick skin that tallyshops ravish institutionally. Danny return espies his catechize Pokeberry came sootily. Bullies do not mini mental score of 20 extensible to evangelize melodically? medians and Andrey caught his laudatory begild phosphated mini coyote plus sans abonnement scenically. unridable scandalous Rufe, his approval emanate provides blusteringly. Jason sledded sophisticated exasperating his histrionic. Chane loud brash undermined their milkshakes. Torrey reticular walks, cleaning your streptokinase ...
Jeg hører ikke til dem der shopper på ebay et par gange om måneden. Alligevel synes jeg at jeg nu har fået købt et passende antal produkter der inde, til at jeg kan udtale mig om min erfaring med ebay. Jeg tænker at dette indlæg vil være ret relevant for dem som slet ikke er vant til at shoppe på ebay, men også for dem som bare vil have lidt inspiration til deres næste køb.. Jeg synes ebay kan være en jungle at finde rundt i. Specielt når jeg ikke ved præcist hvad jeg leder efter eller ikke kender det rette søgeord på det produkt jeg leder efter. Derfor elsker jeg at lure ebay tips på andre blogs. På den måde får jeg god inspiration samt det præcise link til det produkt jeg leder efter, så det er nemt at finde.. Første gang jeg købte noget på ebay var i oktober 2012 og jeg har altså siden hapset lidt flere ting der inde fra. Senest øreringene som I kan se på sidste billede. Jeg modtog dem igår, og de er SÅ fine. I skal også nok snart få dem at se i aktion.. Jeg ...
Update of /cvsroot/cdk/cdk/packages/tar/cdk/jar In directory sc8-pr-cvs1:/tmp/cvs-serv28010/jar Modified Files: Makefile.am Log Message: Easier to read layout Index: Makefile.am =================================================================== RCS file: /cvsroot/cdk/cdk/packages/tar/cdk/jar/Makefile.am,v retrieving revision 1.8 retrieving revision 1.9 diff -u -r1.8 -r1.9 --- Makefile.am 27 May 2003 14:33:52 -0000 1.8 +++ Makefile.am 30 Jun 2003 09:50:59 -0000 1.9 @@ -3,12 +3,25 @@ [email protected]@ JARLIBDIR=${PREFIX}/lib/cdk -JARLIBS=vecmath1.2-1.14.jar postgresql7.0-1.2.jar mysql-2.0.4.jar \ - log4j-core.jar log4j.jar printf.jar \ - gnujaxp.jar baysmith-io.jar dadml.jar JSX1.0.7.4.jar \ - junit.jar xerces-2.3.0.jar batik-awt-util.jar \ - batik-dom.jar batik-util.jar castor-0.9.4.3-xml.jar \ - xindice.jar stmml.jar xmldb.jar +JARLIBS=vecmath1.2-1.14.jar \ + postgresql7.0-1.2.jar \ + mysql-2.0.4.jar \ + log4j-core.jar \ + log4j.jar \ + printf.jar \ + gnujaxp.jar \ + baysmith-io.jar \ + dadml.jar ...
Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85 + 19% vs. 9.0 + 4.8% of the soluble control, respectively). ...
I det siste har jeg blitt ganske flink til å stolhage siden formen har vært så dårlig. Så i går satt jeg ved dammen og funderte på om jeg skulle få satt disse damplantene i kurver som jeg har kjøpt for lenge siden. Jeg fikk tatt opp den ene og fylt kurven med stein. Da jeg skulle sette den ned skvatt jeg skikkelig. Det var en kjempestor frosk som hadde gjemt seg bak denne planten som jeg hadde tatt opp. Den prøvde å komme opp av dammen, men damduken er jo kjempeglatt så det klarte den ikke. Jeg var redd den ville drukne oppe i dammen hvis den ikke kom seg opp. Jeg fikk fanget den opp i en kurv, men da bare hoppet den ut av kurven og forvant opp i dammen igjen. Men da var den i hvertfall kommet på rett side av dammen hvor bekken er og det faktisk er mulig for den å komme seg opp igjen av dammen. Jeg kikket på den sent i går kveld, og da satt den på kanten av plantekurven i det ene hjørnet av dammen. Håper den vil fortsette å bo ved dammen. Koselig med nye husdyr ...
Når det kommer til et sunt og balansert kosthold er det få ting jeg er skikkelig anti. Jeg synes det kan være plass til det ene og det andre i et variert kosthold. Når det er sagt er det èn ting som er på toppen av min Nei takk du, jeg tror jeg finner meg et bedre altermativ-liste. Som overskriften røper er det snakk om sukker. Det hvite raffinerte sukkeret.. Det er snart ti år siden jeg begynte å interessere meg for kosthold og helse, begynte å undervise meg selv om emnet og finne min egen vei. Med årene har helse kommet på agendaen, og folk flest tar interesse i å finne gode og kanskje litt sunnere mat valg enn for 10-20 år siden.. Så, hvorfor er sukkeret på min versting-liste? Alle vet jo at sukker ikke er bra og at det er usunt, men få vet hva som egentlig er greia bortsett fra at sukker gir hull i tennene og det er såkalte tomme kalorier. Tomme kalorier vil si at det gir kalorier, men ikke næring.. Jeg synes det er så mange gode alternativer å finne for å bytte ut ...
Jeg var så heldig at få billet hos Tøndering Strik den dag Annette Danielsen kom på besøg for at præsentere sine 2 nye jubilæumsbøger. Jeg kom hjem med garn til Gili. Jeg satte den lige på ginen i går fordi jeg synes den så stor ud, men på ginen ser det ikke helt skævt ud. Jeg vil lave en tilføjelse med korte eller 3/4 lange ærmer - håber jeg har garn nok ...
Ok, Ive made some progress on this. It seems be a problem using Xerces on a file produced by Saxon. If I use Saxon 8.2b/8.3b with Crimson, it works. If I use MSXML to produce the file it works. Heres the way Im invoking Saxon 8.2b: java -cp C:\aaa\dom.jar;C:\aaa\jaxp-api.jar;C:\aaa\sax.jar;C:\bbb\saxon82b.jar;C: \jakarta-tomcat-5.5.7\common\endorsed\xercesImpl.jar net.sf.saxon.Transform test.xml test.xsl Ive shortened the paths, test.xml is the result of a transform by Saxon 8.3b containing the problem characters, and test.xsl is just basic xsl:copy-of in the root matching template. This fails with: Error java.io.UTFDataFormatException: Invalid byte 2 of 3-byte UTF-8 sequence. Transformation failed: Run-time errors were reported If I specfiy Crimson as the XML parser, the transform is successful: java -cp C:\aaa\dom.jar;C:\aaa\jaxp-api.jar;C:\aaa\sax.jar;C:\bbb\saxon82b.jar;C: \jakarta-tomcat-5.5.7\common\endorsed\xercesImpl.jar net.sf.saxon.Transform -x ...
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Description and explanation of the major themes of The Bell Jar. This accessible literary criticism is perfect for anyone faced with The Bell Jar essays, papers, tests, exams, or for anyone who needs to create a The Bell Jar lesson plan.
Jane Plant var midt under sit femte kr ftangreb. Hun skriver selv: Min kr ft havde spredt sig til lymfekirtlerne p halsen p trods af, at jeg havde f et fjernet hele brystet, tre yderligere operationer, 35 str lebehandlinger, bestr ling af mine ggestokke for at fremkalde menopause samt flere omgange kemoterapi. P trods af alle disse behand-linger mente mine l ger, at jeg kun havde f m neder tilbage at leve i. S kom jeg i tanke om, at mennesker p landet i Kina, hvor jeg havde forsket i jordbundskemi, havde meget lav forekomst af brystkr ft. Jane Plant holdt jeblikkeligt op med at spise m lkeprodukter, og efter f dage begyndte hendes knude p halsen at skrumpe ind, og efter seks uger var den forsvundet. Hun har nu v ret fri for kr ft i mere end 15 r.. Jane Plant har p baggrund af hundredvis af videnskabelige forskningsrapporter kunnet p vise, at m lk og m lkeprodukter er en v sentlig rsag til ikke blot brystkr ft, men ogs ggestokkr ft, prostatakr ft og andre kr ftformer, is r de hormonafh ngige. Hun ...
Jeg cykler og bruger et Garmin Forerunner 405 pulsur. Det er en perfekt træningspartner, men batteritiden er desværre begrænset til 6-8 timer. Nu står jeg for at skulle ud på en 300 km. tur og beregner ca. 10 timer til det. Jeg søger derfor en batteridrevet anordning, som jeg kan have i lommen
Canning jars breaking in your water bath or pressure canner can be perplexing, especially why it happens again and again. Find out about the causes of canning jar breakage and what you can do about it here.
Find Corning® PYREX® Rectangular Chromatography Jars at SpectrumChemical.com now. Great deals on chemicals and chemical supplies.
Its specially developed for babies right? So how come everyone is dead against it? I dont think 50p a jar is that expensive either. Baby led weanin
Hej! Jeg fandt denne fine sten som i virkeligheden vel er aftryk af et eller andet. Kan I hjælpe mig med hvad det er? Jeg venter i spænding. På forhånd tak. Mvh Solveig ...
Ide Hejlskov Ahr, Lars Bo, jeg tror ikke lige mine drømme kan skabe virkelighed, så ville verden også se for syret ud til at det lige kunne håndteres. Astrofysikeren Anja Andersen sagde det til et foredrag på Folkeuniversitetet for et par år siden, er jeg kommet i tanke om, vist nok. ...
Fyl-kes-tin-get i Vest-ag-der sa tirs-dag mot Høy-res stem-mer ja til en ny ut-red-ning av fast-lands-for-bin-del-se til Hid-ra.. - Jeg er for-nøyd med at vi nå kan få re-el-le tall på bor-det. Per-son-lig tror jeg en tun-nel blir det enes-te rea-lis-tis-ke al-ter-na-ti-vet, men vi skal li-ke-vel få ut-re-det uli-ke bro-al-ter-na-ti-ver på nytt, sier Sig-mund Okse-fjell.. Sen-ter-parti-po-li-ti-ke-ren var for-slags-stil-ler til det som til slutt fikk hele fyl-kes-tin-get mi-nus Høy-res stem-mer. Fyl-kes-tin-get ved-tok at uli-ke al-ter-na-tiv for fast-lands-for-bin-del-se til Hid-ra skal ut-re-des på nytt, og at en da skal vur-de-re mind-re på-kos-te-de løs-nin-ger.. Tunnel-al-ter-na-ti-vet som fyl-kes-tin-get tirs-dag ved-tok å få ut-re-det, in-ne-bæ-rer at det må sø-kes om dis-pen-sa-sjon fra EU-for-skrif-te-ne som sier at tun-ne-ler ikke skal ha en stør-re stig-ning enn 5 pro-sent.. Fyl-kes-tin-get får sa-ken om fast-lands-for-bin-del-se til VestAg-ders størs-te øy til ny ...
Dagens glede ute i hagen: Min første lilje er utsprungen, hurra! Den er nydelig, jeg aner ikke hva den heter, og jeg er nesten sikker på at den skulle være mer rødlig :-D ...
Statens lånekasse har en ordning med at lånetaker kan få rentefritak dersom vedkommende kan dokumentere å ha vært arbeidssøkende og lavtlønnet i perioden rentene har løpt. På en og samme tid. Dette var nytt for meg dengang jeg fant det ut (dessverre litt for sent), og det er nytt for alle jeg forteller det til […]
Hey, guess what. We still dont live in an Airstream. I know, broken record. But seriously? I thought we were going to be living in it all the way back in June of 2015! Haha, no. Its still in the shop. Has been since August.... ...
Hallie Jeg må vist erklære mig nogenlunde enig med Caroline. Synes hælen er for lav på Biancos, til at de får der samme fede look. Men kan segfvøllelig også være vinklen på kameraet?? Men ku godt tænke mig at se hvordan den så ud på en fod. 2016-04-28 14:39:45 ...
Jeg indvilliger i, at Esprit Europe GmbH, Esprit Allee, 40882 Ratingen, Tyskland („Esprit) regelmæssigt tilsender nyheder om Esprit mode & livsstil samt info om events (f.eks. åbning af butikker, særarrangementer), konkurrencer og særlige kampagner fra Esprit og virksomheder inden for mode & livsstil, som er tilknyttet Esprit, til min e-mailadresse som angivet ovenfor ...
Idéen er godkendt af manden - og bliver en del af menuen d. 26. februar. Vi holder 8 og 12 års fødselsdag samt kobberbryllup som brunch. Jørgen og jeg er mere til det uformelle end til en middag med suppe, steg og is ...
Fast spalte med interessante og nyttige saker jeg kommer over relatert til trening, kosthold/ernæring og helse generelt. Utgave 10 - I denne utgaven: - Hvordan bør gravide trene? - Carl Yngvar er faen meg sterk! (video) - Er du skada, el? - Proteinpudding oppskrifter og test av Jack3d. - Strekk-refleksen… Les mer. ...
Magrath, I. T.; Golding, P. R.; Bagshawe, K. D. (1971-06-12). "Medical Presentations of Choriocarcinoma". British Medical ...
As of 2020, the reported incidence of choriocarcinoma ranges from 1 in 40 000 pregnancies in North America and Europe, to 9.2 ... "Choriocarcinoma: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2020-12-17. AlJulaih, Ghadeer H.; Muzio, Maria ... The exact pathogenesis of choriocarcinoma has not been fully understood, but studies have shown cytotrophoblast cells function ... Bishop, Bradie N.; Edemekong, Peter F. (2020), "Choriocarcinoma", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID ...
... and choriocarcinoma; clinical and microscopical analysis (20 min; color). PMF 5316 (1957) - The Effect of Ionizing Radiation on ...
Akingba JB, Ayodeji EA (February 1966). "Amenorrhea as a leading symptom of choriocarcinoma". J Obstet Gynaecol Br Commonw. 73 ...
... of women who developed choriocarcinoma died within a year. Today, with chemotherapy, choriocarcinoma can be cured in almost ... Yarris, Jonathan P; Hunter, Alan J (1 May 2003). "Roy Hertz, M.D. (1909-2002): The cure of choriocarcinoma and its impact on ... Within four months she was "normal without evidence of disease." Li treated two additional patients with choriocarcinoma that ... Li, M. C.; Hertz, R.; Spencer, D. B. (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". ...
Surgically removed choriocarcinomas from human patients also exhibited a heavily methylated H19 promoter with enhanced H19 ... Choriocarcinomas, in contrast to adrenal carcinomas, have upregulated H19 and downregulated IGF2 expression. The upregulated ... In cell lines derived from human choriocarcinomas, Kopf et al. found that transcription of H19 was under the simultaneous ... to suggest that in cases of choriocarcinomas, the H19 promoter was mutated, allowing it to overcome the transcriptional ...
They are decreased with toxemia, choriocarcinoma, and Placental insufficiency. The placenta and fetus may be regarded as a ...
Angiomatous (vascular) type : This is the most common type of choriocarcinoma. It is distinguished by the presence of numerous ...
Under light microscopy, the giant malignant pleomorphic cells making up a GCCL resemble those found in choriocarcinoma, ... GCCL and primary pulmonary choriocarcinoma can also be differentiated on the basis of ultrastructural features by electron ... "Primary choriocarcinoma of the lung: case report of two male subjects". Acta Pathol. Jpn. 27 (1): 123-35. PMID 557868. ... a critical distinction to me made because while there is a known standard of care for treating choriocarcinoma, as yet there is ...
Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can ... Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ...
Choriocarcinoma of the testicles has the worst prognosis of all germ-cell cancers. Embryonic stem cells Cancer research Maoz, ... This kind of mixed germ cell tumor may be known simply as a teratoma with elements of embryonal carcinoma or choriocarcinoma, ... Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or ... embryonal carcinoma and/or choriocarcinoma. They can present in the anterior mediastinum. Despite their name, GCTs occur both ...
Ovarian hyperstimulation occurs more often with invasive moles and choriocarcinoma than complete molar pregnancies. A widely ...
Choriocarcinoma tumor cells are TGF-B signaling resistant, as well as lacking Smad3 expression. Studies show that reintroducing ... This suggests that other signaling mechanisms in addition to Smad3 are defective in TGF-B resistant choriocarcinoma. ... Smad3 into choriocarcinoma cells is sufficient to increase TIMP-1 (tissue inhibitor of metalloprotease-1) levels, a mediator of ...
Choriocarcinoma Chorioangioma Herpes Nuclear atypia Nuclear pleomorphism Molar ectopic Arias-Stella, J. (Jan 2002). "The Arias- ...
Choriocarcinomas can be divided into gestational choriocarcinomas and non-gestational choriocarcinomas which have ... "Choriocarcinoma", Wikipedia, 2019-02-23, retrieved 2019-04-10 Smith HO, Berwick M, Verschraegen CF, Wiggins C, Lansing L, ... OGCTs can be classified into dysgerminoma, teratomas, yolk sac tumors, and choriocarcinomas, listed in the order of prevalence ... There are four main types of OGCTs, namely dysgerminomas, yolk sac tumor, teratoma, and choriocarcinoma. Dygerminomas are ...
She was later diagnosed with choriocarcinoma, a form of cancer that occurs in a women's uterus. Some of the common causes of ...
"MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells ...
ADEPT has shown antitumor activity in animal tumor models of human choriocarcinoma and colonic and breast carcinoma. The first ...
"A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature ...
... a human placental choriocarcinoma cell line". Journal of Lipid Research. 47 (4): 815-23. doi:10.1194/jlr.M500527-JLR200. PMID ...
Methotrexate (MTX), approved for the treatment of choriocarcinoma, is frequently used for the medical treatment of an ...
Conversely, if there is too much invasion of uterine tissue by the trophoblast then a hydatidiform mole or choriocarcinoma may ...
Some placental cell lines derived from trophoblasts also express C19MC miRNA, including the choriocarcinoma lines JEG3, JAr, ...
CS1 maint: discouraged parameter (link) - study on mice in which human choriocarcinoma had been implanted "Oral Chemotherapy ...
... choriocarcinomas, and seminoma are tumors that produce the β-hCG hormone. The hormones that are produced by the tumors can be ... choriocarcinoma, embryonal carcinoma, gonadoblastoma, teratoma & yolk sac tumor Mixed GCTs: a combination of EGCTs. Common ...
Lawler's work on human leukocyte antigens (HLA) provided evidence that choriocarcinomas may arise from an earlier rather than ... and choriocarcinoma, and in efforts to improve the diagnosis and treatment of this disease. ...
choriocarcinoma, ICD-O 9100/3). *guz pęcherzyka żółtkowego (ang. endodermal sinus tumor, ICD-O 9071/3) ...
Examples include: Choriocarcinoma Hydatidiform mole In placental disease, there's abnormalities present within the spiral ...
In December 2013, Arnold revealed that she was diagnosed with a rare form of cancer, stage 4 choriocarcinoma, due to a non- ...
Stage I choriocarcinoma Stage 2 choriocarcinoma Stage 3 choriocarcinoma Stage 4 choriocarcinoma "choriocarcinoma" at Dorlands ... Elements of choriocarcinoma in a mixed testicular tumor have no prognostic importance. Choriocarcinomas can also occur in the ... The same is true of choriocarcinoma arising in the ovary. Testicular choriocarcinoma has the worst prognosis of all germ-cell ... Choriocarcinoma of the placenta during pregnancy is preceded by: hydatidiform mole (50% of cases) spontaneous abortion (20% of ...
"Choriocarcinoma". Retrieved 10 August 2012. CS1 maint: discouraged parameter (link) NIH. "Choriocarcinoma". Retrieved 10 August ... "Choriocarcinoma". Retrieved 10 August 2012. CS1 maint: discouraged parameter (link) NIH. "Choriocarcinoma". Retrieved 10 August ... Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ...
Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy. ... Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). They may also occur after an ...
Choriocarcinoma is a form of cancer that occurs in the female reproductive system. The following Buzzle article elaborates more ... Choriocarcinoma is a type of cancer that develops in a womans uterus (womb). In choriocarcinoma, the placenta that begins to ... Choriocarcinoma is a form of cancer that occurs in the female reproductive system. The following Buzzle article elaborates more ... In some cases, women after healthy delivery may also get choriocarcinoma Symptoms. The patient may not show any symptoms, until ...
Pure choriocarcinoma of the testis is the exception to most of the rules established for testicular seminoma and all other ... Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with ... Testicular Choriocarcinoma Medication. Updated: Apr 04, 2017 * Author: Michael B Williams, MD, MS; Chief Editor: Bradley Fields ... Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. Am J Surg ...
... , Chorioblastoma, Trophoblastic Tumor, Chorioepithelioma, Gestational Trophoblastic Neoplasia, Invasive Mole, ... Choriocarcinomas, [M]Choriocarcinoma, [M]Chorioepithelioma, choriocarcinoma, choriocarcinoma (diagnosis), Choriocarcinoma, no ... Choriocarcinoma (disorder), Choriocarcinoma, NOS, Choriocarcinoma, Chorioepithelioma NOS, Choriocarcinoma (morphologic ... Choriocarcinoma. Choriocarcinoma Aka: Choriocarcinoma, Chorioblastoma, Trophoblastic Tumor, Chorioepithelioma, Gestational ...
Home Education AUAUniversity Education Products & Resources Pathology for Urologists Testis Germ Cell Tumors Choriocarcinoma ... Pure choriocarcinoma is very rare and accounts for ,1% of GCTs.. *Usually is mixed with other GCT components (8% of mixed GCT). ... Classic choriocarcinoma *Mixture of cytotrophoblasts (polygonal cells with clear cytoplasm, bland nucleus and prominent cell ...
... Parth Rali,1 Jianwu Xie,2 Grishma Rali,3 Mayur Rali,4 Jan Silverman,2 ... M. Schulz, A. Hernandez, and F. Rebora, "Primary chorio-carcinoma of the lung; Case report," Rev Mex Tuberc Enferm Apar Respir ... U. B. M. Kinni, "Primary pulmonary choriocarcinoma: Is it still an enigma," Indian Journal of Chest Diseases and Allied ... X. M. Li, X. Y. Liu, and Z. X. Liu, "Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: ...
In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on ... and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. ... are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, ... Keywords: choriocarcinoma; epigenetics; histone deacetylase inhibitors choriocarcinoma; epigenetics; histone deacetylase ...
Choriocarcinoma is a rare uterine cancer following pregnancy. The tumor arises in the trophoblast cells lining the embryo. ... What is Choriocarcinoma in Females?. Choriocarcinoma is a rare, rapid or fast-growing form of malignant cancer that occurs in ... Since choriocarcinoma occurs most often as a result of pregnancy, it is called gestational choriocarcinoma. There are non- ... How to Diagnose Choriocarcinoma in Females?. Diagnosis of choriocarcinoma is made based on the history of the patient and ...
Thirty-one papers originally presented at a conference held in the Philippines, January 1965. Data and discussions on pathology, natural history, diagnosis, and treatment (with emphasis on chemotherapy). The classifications of trophoblastic neoplasms adopted for recommendation to the UICC are presented as Appendix I. Illustrations and bibliographies. ...
"Choriocarcinoma" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Choriocarcinoma" by people in Harvard Catalyst Profiles by ... Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON- ... Durable remission for a woman with refractory choriocarcinoma treated with anti-endoglin monoclonal antibody and bevacizumab: A ...
... Proteomics. 2004 Mar;4(3):861-7. ... we performed proteomic analysis on the human choriocarcinoma cell line JEG-3, incubated under high oxygen tension (carbogen, 95 ...
Choriocarcinoma is one of the two rarest forms of cancer, but highly treatable. This condition strikes pregnant women, and ... Choriocarcinomas can develop after an abortion, ectopic pregnancy, or genital tumor.. Choriocarcinoma Signs & Symptoms. Some ... Choriocarcinoma Diagnosis & Treatment. One of the biggest risks with this type of cancer is that it can spread quickly to other ... Choriocarcinoma is one of the two rarest forms of cancer, but highly treatable. This condition strikes pregnant women, and ...
Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, ... Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, ... Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute ...
Trophoblastic Neoplasms Choriocarcinoma Device: atomic force microscopy Device: dual polarisation interferometry Phase 4 ... Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma. The safety and scientific validity ... Choriocarcinoma. Trophoblastic Neoplasms. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. ... choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is ...
Choriocarcinoma may occur when an embryo fails to develop, but the placental tissue continues to proliferate. - Stock Image ... in a case of a choriocarcinoma. This is a malignant (cancerous) tumour of trophoblast cells of the placenta. Trophoblast cells ... Keywords: abnormal, cancer, cancerous, carcinoma, cell, choriocarcinoma, disease, female, histology, histopathology, human, ... Caption: Light micrograph of a section through tissue from the uterus, in a case of a choriocarcinoma. This is a malignant ( ...
Preliminary Diagnosis: Choriocarcinoma/Molar Preganancy. I. What imaging technique is first-line for this diagnosis?. *. ... V. Describe the advantages and disadvantages of the alternative techniques for diagnosis of choriocarcinoma/molar pregnancy. * ... Describe the advantages and disadvantages of this technique for diagnosis of choriocarcinoma/molar pregnancy. * Advantages ... Describe the advantages and disadvantages of this technique for diagnosis of choriocarcinoma/molar pregnancy.. Advantages. *. ...
Infantile choriocarcinoma with cutaneous, liver, and lung metastases. By Logan Dance, MD; Apurvi Patel, MD; Mittun Patel, MD; ... Choriocarcinoma is notorious for its life-threating hemorrhagic metastases and famous for being the first solid tumor to be ... Solitary infantile choriocarcinoma of the liver: MRI findings. Pediatr Radiol. 2004 Oct;34(10):820-823. Epub 2004 Jul 28. ... Dance L, Patel A, Patel M, Towbin AJ, Towbin R. Infantile choriocarcinoma with cutaneous, liver, and lung metastases. Appl ...
Primary choriocarcinoma of the ovary arising, presumably, from a germ cell is extremely rare. The patient, a 16 year old girl ... of micturition developed fatal haemoperitoneum due to rupture of a pure primary nongestational ovarian choriocarcinoma. ...
17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like ... we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like ...
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY ... Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational ... Non-gestational Choriocarcinoma (Choriocarcinoma, Non gestational). Subscribe to New Research on Non-gestational ... 01/01/1986 - "Eight choriocarcinoma cell lines (Two SCH and IMa, were established from non-gestational choriocarcinoma and the ...
Definition: Testicular choriocarcinoma is non-seminomatous germ cell tumor arising within the testis. These tumors recapitulate ... Definition: Testicular choriocarcinoma is non-seminomatous germ cell tumor arising within the testis. These tumors recapitulate ... If there is a greater amount of choriocarcinoma admixed in a germ cell tumors, it has an adverse effect on survival. ... Home , E. Pathology by systems , Reproductive system , Male genital system , Testis , testicular choriocarcinoma ...
OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells Message Subject (Your Name) has forwarded a page to ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ...
Abstract #4106: Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma. Hui-Juan Zhang, Michelle Siu, ... Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser ... However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression ... Immunohistochemical analysis in choriocarcinoma tissue samples confirmed significantly higher p-PKB (Ser473) expression ...
... gestational ovarian choriocarcinoma, pure nongestational ovarian choriocarcinoma, and choriocarcinoma of uncertain etiology. ... Choriocarcinoma of the ovary can be pure choriocarcinoma or, more commonly, mixed with other germ cell components [1]. When ... Not pure choriocarcinoma. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with ... Not pure choriocarcinoma. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with ...
... Cell Immunol. 1990 ... Both fetal fibroblasts and JEG-3 choriocarcinoma cells are resistant to lysis by freshly isolated decidual effectors but are ...
Part I. Hydatidiform Mole and Choriocarcinoma. Ann Intern Med. ;48:442. doi: 10.7326/0003-4819-48-2-442 ...
Choriocarcinoma vulva is a clinical form of trophoblastic tumors which one must think before all lesions with positive plasma ... The biopsy of the mass objectified choriocarcinoma of vulvar. A methotrexate-based agent chemotherapy was introduced. The ... The biopsy of the mass objectified choriocarcinoma of vulvar. A methotrexate-based agent chemotherapy was introduced. The ... Choriocarcinoma vulva is an exceptional location of gestational trophoblastic tumors. We report the case of a female patient of ...
Choriocarcinoma coexisting with or after an otherwise normal pregnancy is extremely rare, with an estima ... Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by ... Choriocarcinoma / metabolism, pathology*. Female. Humans. Immunohistochemistry. Incidental Findings. Pregnancy. Term Birth. ... Choriocarcinoma coexisting with or after an otherwise "normal" pregnancy is extremely rare, with an estimated occurrence of 1 ...
  • About one half of all women with a choriocarcinoma had a hydatidiform mole, or molar pregnancy. (medlineplus.gov)
  • Sometimes, the hydatidiform mole spreads to surrounding tissues and becomes malignant, resulting in choriocarcinoma. (medindia.net)
  • Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). (harvard.edu)
  • Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. (clinicaltrials.gov)
  • A choriocarcinoma is even rarer than a hydatidiform mole. (mskcc.org)
  • Unlike a hydatidiform mole, a choriocarcinoma is a malignant and more aggressive form of GTD that spreads into the muscle wall of the uterus. (mskcc.org)
  • Choriocarcinoma arises from the chorionic epithelium of placentas in association with hydatidiform mole, recent abortion or full term pregnancy (1). (annalsofafricansurgery.com)
  • The development of Choriocarcinoma leads by other pregnancy related conditions like hydatidiform mole, which constitutes 50% of all cases. (cancerworld.info)
  • Gestational Choriocarcinoma that usually arises from hydatidiform mole has been found to be sensitive to chemotherapy. (cancerworld.info)
  • Metastatic pure choriocarcinoma is treated with the same multi-agent chemotherapy regimens used in nonseminomatous germ cell tumors (NSGCTs), which are discussed in a separate article (see Nonseminomatous Testicular Tumors ). (medscape.com)
  • Chen X, Xu L, Chen X, Teng X, Zheng S. Testicular choriocarcinoma metastatic to skin and multiple organs. (medscape.com)
  • Ramon y Cajal S, Pinango L, Barat A. Metastatic pure choriocarcinoma of the testis in an elderly man. (medscape.com)
  • Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. (medworm.com)
  • There are three ways in which an ovarian choriocarcinoma can arise: as a primary gestational choriocarcinoma that results from an ectopic ovarian pregnancy, as a metastatic choriocarcinoma that arises from a gestational choriocarcinoma, and as a germ cell tumor with differentiation into trophoblastic structures. (oatext.com)
  • Severe lower gastrointestinal bleeding due to metastatic choriocarcinoma to the jejunum: A rare presentation. (alliedacademies.org)
  • Pathologic examination was compatible with metastatic choriocarcinoma to the jejunum. (alliedacademies.org)
  • A monotherapy with etoposide has also good effects on metastatic choriocarcinoma and can be discussed [3]. (oatext.com)
  • The final histopathologi-cal diagnosis was indicated as choriocarcinoma, possi-bly metastatic to the GIT. (annalsofafricansurgery.com)
  • Metastatic Choriocarcinoma prognosis and life expectancy was once grim. (cancerworld.info)
  • Pulmonary Metastatic Choriocarcinoma in a Patient with Ectopic Pregnancy', Journal of Midwifery and Reproductive Health , 5(4), pp. 1107-1112. (ac.ir)
  • After further investigations, metastatic choriocarcinoma was diagnosed. (ac.ir)
  • One rare case of metastatic cerebral choriocarcinoma with initial presentation of intracerebral Haemorrhage is reported. (scitechnol.com)
  • The patient underwent an exploratory laparotomy that revealed metastatic choriocarcinoma in the left broad ligament. (uab.edu)
  • CONCLUSION: PET/CT may be useful in the evaluation of occult choriocarcinoma when conventional imaging fails to identify metastatic disease. (uab.edu)
  • This chapter presents the role of mammography and color Doppler ultrasound in the diagnosis of metastatic choriocarcinoma to the breast. (uthscsa.edu)
  • Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute pancreatitis in a 27-yr-old woman following a molar pregnancy. (medworm.com)
  • Describe the advantages and disadvantages of this technique for diagnosis of choriocarcinoma/molar pregnancy. (psychiatryadvisor.com)
  • V. Describe the advantages and disadvantages of the alternative techniques for diagnosis of choriocarcinoma/molar pregnancy. (psychiatryadvisor.com)
  • Around 50% of choriocarcinomas occur after a molar pregnancy, 30% develop following an ectopic pregnancy or a miscarriage, and 20% are encountered following a normal pregnancy. (fertilitysmarts.com)
  • I learned these firsthand when I was on the aggressive 5 agent cocktail known as ema-co for placental cancer choriocarcinoma from my complete twin molar pregnancy. (choriocarcinomamolarpregnancyawareness.com)
  • Choriocarcinoma most commonly follows a molar pregnancy , spontaneous abortion , or ectopic pregnancy . (wikidoc.org)
  • One must be cautious while taking a biopsy of the choriocarcinoma due to the high chance of bleeding, as such tumors are high in blood vessels. (medindia.net)
  • Considered one of the fastest growing tumors, infantile choriocarcinoma classically presents with hepatomegaly, anemia, failure to thrive, and precocious puberty between 0 days and 5 months of life. (appliedradiology.com)
  • If there is a greater amount of choriocarcinoma admixed in a germ cell tumors, it has an adverse effect on survival. (humpath.com)
  • Choriocarcinoma vulva is an exceptional location of gestational trophoblastic tumors. (panafrican-med-journal.com)
  • Choriocarcinoma vulva is a clinical form of trophoblastic tumors which one must think before all lesions with positive plasma beta-h-CG, especially in a woman of childbearing age and the waning of a pregnancy event. (panafrican-med-journal.com)
  • Most cases of persistent GTD are invasive moles, but in rare cases they are choriocarcinomas or placental site trophoblastic tumors (see below). (cancer.org)
  • Tumors of germ cell origin (e.g., mature teratoma, malignant teratoma, endodermal sinus tumor [yolk sac tumor], embryonal carcinoma, dysgerminoma, primary choriocarcinoma) constitute approximately 70% of ovarian tumors in children ( Table 1 ). (glowm.com)
  • Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. (medscape.com)
  • Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. (mdpi.com)
  • Choriocarcinomas can develop after an abortion, ectopic pregnancy, or genital tumor. (knowcancer.com)
  • The differential diagnosis of lesions presenting with cutaneous involvement (ordered most to least common) include: leukemia, Langerhans cell histiocytosis, neuroblastoma, rhabdoid tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, choriocarcinoma, and adrenocortical carcinoma. (appliedradiology.com)
  • Choriocarcinoma is notorious for its life-threating hemorrhagic metastases and famous for being the first solid tumor to be cured with chemotherapy alone (methotrexate, 1956). (appliedradiology.com)
  • Testicular choriocarcinoma is non-seminomatous germ cell tumor arising within the testis . (humpath.com)
  • Choriocarcinoma of the ovary is a rare and highly malignant germ cell tumor. (oatext.com)
  • By examining the DNA composition of the tumor and comparing it to the maternal and paternal DNA, the etiology of the choriocarcinoma can be determined. (oatext.com)
  • The symptoms of a choriocarcinoma vary, depending on where the tumor originates and where it spreads. (thefreedictionary.com)
  • Choriocarcinomas are usually treated by surgical removal of the tumor and chemotherapy . (thefreedictionary.com)
  • n. coriocarcinoma, tumor maligno visto gen. en el útero y en los testículos. (thefreedictionary.com)
  • Generally, the trophoblastic disease that occurs after a normal pregnancy could either be a choriocarcinoma or a placental site trophoblastic tumor but not a benign or an invasive mole. (fertilitysmarts.com)
  • Choriocarcinoma if detected in early stages it is a highly curable tumor related to pregnancy. (cancerworld.info)
  • Infantile choriocarcinoma of the liver is a very rare tumor that starts in the placenta and spreads to the fetus . (oncolink.org)
  • Choriocarcinoma is a highly malignant tumor of trophoblastic origin. (biomedcentral.com)
  • Choriocarcinoma is a highly malignant trophoblastic tumor composed of two types of cells, syncytiotrophoblasts and cytotrophoblasts. (biomedcentral.com)
  • Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia . (scitechnol.com)
  • Choriocarcinoma is a germ cell tumor containing syncytiotrophoblastic cells and secreting human Beta-HCG. (beds.ac.uk)
  • Microscopically, the tumor was characteristic of choriocarcinoma, with large multinucleated cells representing syncytiotrophoblast admixed with medium-sized cells, often with clear cytoplasm, similar to cytotrophoblasts or intermediate trophoblasts (Figure n.2). (beds.ac.uk)
  • The tumor therefore was diagnosed pathologically as choriocarcinoma. (beds.ac.uk)
  • Choriocarcinoma is a malignant tumor of the trophoblastic epithelium . (wikidoc.org)
  • Non-gestational ovarian choriocarcinoma is observed in pre-pubertal girls. (medindia.net)
  • The patient, a 16 year old girl who presented with dysuria and frequency of micturition developed fatal haemoperitoneum due to rupture of a pure primary nongestational ovarian choriocarcinoma. (bmj.com)
  • Ovarian choriocarcinomas are therefore classified as gestational or nongestational . (oatext.com)
  • The incidence of primary ovarian nongestational choriocarcinoma is estimated to be 1 in 369,000,000 [4]. (oatext.com)
  • published a comprehensive literature review on pure ovarian choriocarcinoma [6]. (oatext.com)
  • The study classified all published cases of pure ovarian choriocarcinoma at the time into three categories: gestational ovarian choriocarcinoma, pure nongestational ovarian choriocarcinoma, and choriocarcinoma of uncertain etiology. (oatext.com)
  • The pure nongestational ovarian choriocarcinoma category was assigned to all pure ovarian choriocarcinoma cases occurring in prepubertal females, and the uncertain etiology was assigned to all pure ovarian choriocarcinoma cases in postpubertal women who were said to be sexually abstinent or virginal. (oatext.com)
  • Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and primary non-gestational choriocarcinoma of ovary . (malacards.org)
  • An important gene associated with Non-Gestational Ovarian Choriocarcinoma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway . (malacards.org)
  • Further indications of Choriocarcinoma include pain, swelling of the uterus, ovarian cysts, abdominal swelling, irregular vaginal bleeding, nausea and vomiting, anemia, Increased HCG levels that do not return to normal even after pregnancy, the size of the uterus does not change even after delivery and lump in the vagina. (cancerworld.info)
  • Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. (wikipedia.org)
  • Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. (wikipedia.org)
  • Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. (medlineplus.gov)
  • Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). (medlineplus.gov)
  • In choriocarcinoma, the placenta that begins to form during pregnancy is replaced by a rapidly growing abnormal tissue. (buzzle.com)
  • Since choriocarcinoma occurs most often as a result of pregnancy, it is called gestational choriocarcinoma. (medindia.net)
  • If the hCG levels are high and choriocarcinoma is suspected due to an earlier pregnancy, then other tests are conducted. (medindia.net)
  • In the genetic analysis, you will be able to understand the type of pregnancy that caused choriocarcinoma. (medindia.net)
  • Recurrent Cerebral Hemorrhage in Normal Pregnancy Secondary to Mycotic Pseudoaneurysms Related to Choriocarcinoma. (harvard.edu)
  • Gestational choriocarcinoma is a form of gestational trophoblastic disease, which arises from a partial mole, a complete mole, or a normal pregnancy. (oatext.com)
  • Nongestational choriocarcinoma does not arise from a pregnancy event and is an extremely rare occurrence. (oatext.com)
  • Traditionally, a definitive diagnosis of nongestational choriocarcinoma has been restricted to prepubescent females in whom the possibility of a pregnancy event can be eliminated with certainty. (oatext.com)
  • Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (biomedsearch.com)
  • Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole. (biomedsearch.com)
  • Choriocarcinoma coexisting with or after an otherwise "normal" pregnancy is extremely rare, with an estimated occurrence of 1 per 160,000 pregnancies. (biomedsearch.com)
  • We here report a case of a placental choriocarcinoma with no metastases in a full-term intrauterine pregnancy. (biomedsearch.com)
  • Most choriocarcinomas make human chorionic gonadotropin (hCG), a hormone normally found only during pregnancy. (thefreedictionary.com)
  • A woman with a choriocarcinoma may register a positive home urine pregnancy. (mskcc.org)
  • Gestational choriocarcinoma is a rapidly growing cancer that occurs during pregnancy and originates in the tissue that would normally develop into a placenta. (fertilitysmarts.com)
  • Normal term pregnancy may also result to 20 to 30% of Choriocarcinoma. (cancerworld.info)
  • This article concerns a case of choriocarcinoma developing 38 years after the patient's last pregnancy and 23 years after menopause. (biomedcentral.com)
  • Extrauterine gestational choriocarcinomas may also arise at a site of ectopic pregnancy. (biomedcentral.com)
  • Here, we describe a case of choriocarcinoma in a 73-year-old woman developing 38 years after her last pregnancy and 23 years after her last menstrual period. (biomedcentral.com)
  • Gestational choriocarcinoma usually arises in the uterine cavity and is associated with coincident or antecedent pregnancy. (bmj.com)
  • Our case represents a primary choriocarcinoma of the cervix, which was initially misdiagnosed as an ectopic pregnancy. (bmj.com)
  • Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancy. (uab.edu)
  • Less commonly, choriocarcinoma can also follow a full-term pregnancy . (wikidoc.org)
  • Puri S, Sood S, Mohindroo S, Kaushal V. Cytomorphology of lung metastasis of pure choriocarcinoma of testis in a 58-year-old male. (medscape.com)
  • Choriocarcinoma of the ovary can be pure choriocarcinoma or, more commonly, mixed with other germ cell components [1]. (oatext.com)
  • Histological diagnosis by autopsy was pure choriocarcinoma. (elsevier.com)
  • We report a case of multiple gastrointestinal tumours that showed features of pure choriocarcinoma. (annalsofafricansurgery.com)
  • Choriocarcinoma is a fast-growing cancer that occurs in a woman's uterus (womb). (medlineplus.gov)
  • Choriocarcinoma is a type of cancer that develops in a woman's uterus (womb). (buzzle.com)
  • Light micrograph of a section through tissue from the uterus, in a case of a choriocarcinoma. (sciencephoto.com)
  • On uterus evaluation, tumoral mass compatible with choriocarcinoma was detected. (alliedacademies.org)
  • Choriocarcinomas resemble the cells that surround an embryo in the uterus. (thefreedictionary.com)
  • The prognosis for choriocarcinomas in the uterus is very good. (thefreedictionary.com)
  • Choriocarcinoma is the type of cancer which grows rapidly in the uterus (womb) of a woman, with the abnormal cells starting in the tissue would normally become the placenta. (healthician.org)
  • She had a history of labor one year earlier, and we diagnosed her condition as metastasis of gestational choriocarcinoma to the duodenum, probably originating in the uterus or placenta. (elsevier.com)
  • Choriocarcinomas form in the uterus after fertilization of an egg by a sperm. (fertilitysmarts.com)
  • Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a woman's uterus (womb). (cancerworld.info)
  • A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. (curehunter.com)
  • Infantile hepatic choriocarcinoma is a rare, highly malignant germ-cell tumour believed to result from a choriocarcinoma of the placenta that spreads to the child. (elsevier.com)
  • Choriocarcinoma of non-placental origin is a highly malignant carcinoma with poor prognosis. (kjpbt.org)
  • Choriocarcinomas may also arise from ectopic pregnancies, the gonads, or midline sites, such as the mediastinum, retroperitoneum, and pineal gland, oc-curring as germ cell tumours (2). (annalsofafricansurgery.com)
  • We present an unusual case of a testicular choriocarcinoma metastasized to the buccal mucosa mimicking a reactive lesion. (hilarispublisher.com)
  • Histopathological examination reveals testicular choriocarcinoma. (hilarispublisher.com)
  • Choriocarcinoma of the Testis is a type of testicular cancer affecting the germ cells. (dovemed.com)
  • Choriocarcinoma of the Testis is a rare and very aggressive form of testicular cancer. (dovemed.com)
  • But testicular Choriocarcinoma is not responsive to anticancer drugs and has a poor prognosis. (cancerworld.info)
  • It is rare for choriocarcinoma to develop following menopause although a case has been reported with metastases to the lymph nodes, skull, neck, and lungs. (medindia.net)
  • Herein, we report a 47-year-old woman who presented with acute pancreatitis and left hemianopsia and was diagnosed with pancreatic choriocarcinoma with multiple metastases in liver, lung, and brain. (kjpbt.org)
  • Salvador Tarrason, R, Pont Valles, J & Duran De Hoyos, A 1979, ' Spontaneous pneumothorax due to cavitated pulmonary metastases from Choriocarcinoma ', Acta Obstetrica y Ginecologica Hispano-Lusitana , vol. 27, no. 8, pp. 549-555. (uab.cat)
  • The misdiagnosis of infantile choriocarcinoma for infantile hemangioma has occurred as described in a 2014 case report by Brooks and Nolting 4 also with a solitary cutaneous metastasis to the face. (appliedradiology.com)
  • Diagnostic showed a metastasis choriocarcinoma in the lung. (oatext.com)
  • The dissemination of metastasis is typical for high-risk choriocarcinoma. (oatext.com)
  • Eight cases of choriocarcinoma in the duodenum were reported in the literature, but our case is the first one of metastasis of gestational choriocarcinoma to the duodenum. (elsevier.com)
  • Other Choriocarcinoma Signs and Symptoms depend on metastasis so with liver metastasis there is a bleeding due to ruptured liver. (cancerworld.info)
  • In Europe, there are only rare cases of choriocarcinoma whereas in Asia and Africa the incidence is much higher [1,2]. (oatext.com)
  • Most cases of choriocarcinoma are intra-uterine and of gestational origin. (biomedcentral.com)
  • Primary nongestational choriocarcinoma of the ovary. (bmj.com)
  • Primary choriocarcinoma of the ovary arising, presumably, from a germ cell is extremely rare. (bmj.com)
  • Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational , is related to choriocarcinoma of ovary and endometrial cancer . (malacards.org)
  • Choriocarcinomas in other sites have a poorer prognosis. (thefreedictionary.com)
  • The prognosis of Choriocarcinoma patient depends on the stage at which the condition is diagnosed. (cancerworld.info)
  • Choriocarcinoma Prognosis for patients whose disease has not metastasized and even cancer has extend can typically expect a 90% to 95% cure rate. (cancerworld.info)
  • Is chemotherapy always necessary for patients with nonmetastatic gestational trophoblastic neoplasia with histopathological diagnosis of choriocarcinoma? (harvard.edu)
  • In high risk choriocarcinoma the gold standard for treatment is a multi-agent chemotherapy with etoposide, actinomycin D, methotrexate, cyclophophamid and vincristine (EMACO). (oatext.com)
  • Chemotherapy with surgery is the main type of treatment for Choriocarcinoma. (cancerworld.info)
  • The effect of progesterone on MMP-2 expression in the JAR human choriocarcinoma cell line was analyzed by gelatin zymography. (biomedcentral.com)
  • Huisman, Thierry A G M. / Solitary infantile choriocarcinoma of the liver : MRI findings . (elsevier.com)
  • The biopsy diagnosis of the duodenum and liver was choriocarcinoma. (elsevier.com)
  • A choriocarcinoma can also spread more widely to other parts of the body such as the lungs, liver, and/or brain. (mskcc.org)
  • Choriocarcinoma can invade the uterine tissue and vasculature and spread to distant sites such as lungs , brain , liver , pelvis , vagina , spleen , intestines , and kidney . (wikidoc.org)
  • abstract = "A 25-year-old woman, presenting with miliary shadowing on chest radiography, was found to have hyperthyroidism and choriocarcinoma. (elsevier.com)
  • In the current study, we investigated the cytotoxicity induced by NB and nHAPs in human choriocarcinoma (JAR) cells and attempted to probe the relationship between placenta calcification and NB. (springeropen.com)
  • The cells of the choriocarcinoma produce the hormone human chorionic gonadotrophin (hCG). (medindia.net)
  • Shen Y, Yang J, Zhao J, Xiao C, Xu C, Xiang Y. The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells. (harvard.edu)
  • 17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture. (nih.gov)
  • To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. (nih.gov)
  • The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by Matrigel invasion assay, MTT assay, TUNEL and flow cytometry, respectively. (aacrjournals.org)
  • The invasive activity and viability of choriocarcinoma cells were significantly decreased. (aacrjournals.org)
  • Both fetal fibroblasts and JEG-3 choriocarcinoma cells are resistant to lysis by freshly isolated decidual effectors but are readily killed by IL-2-stimulated decidual LGL. (nih.gov)
  • Histopathological analysis of the biopsy showed syncytiotrophoblast-like cells with multiple, large nuclei, consistent with choriocarcinoma. (go.jp)
  • Regulation of glycogen synthase activity in choriocarcinoma cells. (eurekamag.com)
  • The restriction of cell-free HIV-1 infection has been demonstrated in placental trophoblast choriocarcinoma BeWo cells. (pasteur.fr)
  • A choriocarcinoma is type of cancer germ cell containing trophoblast cells. (thefreedictionary.com)
  • Choriocarcinomas are cancers that develop from germ cells, cells that ordinarily turn into sperm or eggs. (thefreedictionary.com)
  • Choriocarcinoma JEG-3 cells were transfected with either pEGFP or pEGFP-GRA15 II and cultured for 24 h. (biomedcentral.com)
  • Toxoplasma GRA15 II induced ERS and subsequently caused apoptosis of choriocarcinoma JEG-3 cells. (biomedcentral.com)
  • However, very rarely, choriocarcinoma can develop from germ cells or from dedifferentiation of endometrial carcinoma into choriocarcinoma. (biomedcentral.com)
  • The non-gestational choriocarcinomas are believed to develop from pluripotent germ cells, most commonly arising in the gonads. (biomedcentral.com)
  • We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. (springeropen.com)
  • Coumestrol induces apoptotic effects on placental choriocarcinoma cells. (greenmedinfo.com)
  • Y. Ikura, T. Inoue, H. Tsukuda, T. Yamamoto, M. Ueda, and Y. Kobayashi, "Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: Are they independent entities? (hindawi.com)
  • Miliary mottling on lung fields plus hyperthyroidism - miliary tuberculosis or choriocarcinoma? (elsevier.com)
  • Primary choriocarcinoma of the lung is extremely uncommon. (beds.ac.uk)
  • We report a surgically treated case of choriocarcinoma in a 37-year-old woman who came to our attention because of a isolated lung lesion. (beds.ac.uk)
  • U. B. M. Kinni, "Primary pulmonary choriocarcinoma: Is it still an enigma," Indian Journal of Chest Diseases and Allied Sciences , vol. 47, pp. 216-226, 2007. (hindawi.com)
  • Primary pulmonary choriocarcinoma: Case report and review of the literature," Gynecologic and Obstetric Investigation , vol. 74, no. 2, pp. 171-176, 2012. (hindawi.com)
  • A 12-year-old boy with primary intracranial choriocarcinoma of the pineal region suffered from repeated intratumoral hemorrhage over a short period. (operativeneurosurgery.com)
  • Primary extragonadal choriocarcinomas present with unusual clinical features and as such are difficult to di-agnose (3).The pathogenesis of these tumours is still uncertain. (annalsofafricansurgery.com)
  • Primary gestational choriocarcinoma of the uterine cervix. (bmj.com)
  • Mushtaq M (2015) Choriocarcinoma Presenting as Intracerebral Haemorrhage and No Evident Primary: Rare Presentation. (scitechnol.com)
  • Primary extragenital choriocarcinoma most often arises in the retroperitoneum, in the mediastinum, or intracranially. (beds.ac.uk)
  • When examined histologically, if other germ cell components are present mixed with choriocarcinoma, a diagnosis of a nongestational origin can be made. (oatext.com)
  • Choriocarcinomas are one of the most dangerous germ cell cancers. (thefreedictionary.com)
  • Choriocarcinomas result from genetic damage to a germ cell. (thefreedictionary.com)
  • Vaginal and uterine biopsies were suggestive of choriocarcinoma. (biomedcentral.com)
  • Extrauterine choriocarcinomas are very rare entities, and most of these are located in the uterine cervix. (bmj.com)
  • The cause for Choriocarcinoma of the Testis, unlike that of the ova, is unknown. (dovemed.com)
  • Who gets Choriocarcinoma of the Testis? (dovemed.com)
  • What are the Risk Factors for Choriocarcinoma of the Testis? (dovemed.com)
  • Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. (wikipedia.org)
  • pathology was consistent with choriocarcinoma. (appliedradiology.com)
  • Differentiating gestational and nongestational choriocarcinoma can be difficult, as their clinical presentation and pathology can be identical. (oatext.com)
  • What are the Symptoms and Signs of Choriocarcinoma in Females? (medindia.net)
  • Here are certain symptoms of Choriocarcinoma, with careful examination, management and early diagnosis of the disease outcomes can be improved. (cancerworld.info)
  • Symptoms of Choriocarcinoma commonly depend on the type of the body part affected. (cancerworld.info)
  • What are the Causes of Choriocarcinoma in Females? (medindia.net)
  • The clinicians were appraised of the findings suggestive of choriocarcinoma, and requested to evaluate serum hCG. (annalsofafricansurgery.com)
  • The cancers give rise to features similar to choriocarcinoma. (medindia.net)
  • Most often this is an invasive mole, but in rare cases it is a choriocarcinoma, a malignant (cancerous) form of GTD. (cancer.org)
  • Hydatidifporm mole, the leading cause of Choriocarcinoma is the development of grape-like structure that should have normally formed the embryo. (cancerworld.info)
  • Non-gestational, extragonadal choriocarcinoma is a rare disease and pancreatic choriocarcinoma is an extremely rare disease. (kjpbt.org)
  • There is no standard therapy for extragonadal choriocarcinoma. (kjpbt.org)
  • The imaging findings of infantile choriocarcinoma include marked, early peripheral enhancement with central necrosis and hemorrhage. (appliedradiology.com)
  • To improve the accuracy of diagnosis, we present the imaging findings of contrast-enhanced dynamic MRI in a 4.5-month-old boy with infantile hepatic choriocarcinoma. (elsevier.com)
  • Choriocarcinoma may occur when an embryo fails to develop, but the placental tissue continues to proliferate. (sciencephoto.com)
  • nonetheless, a choriocarcinoma can occur after a normal conception. (fertilitysmarts.com)
  • Fazle Razik , Choriocarcinoma of the fallopian tube, J. Pak. (who.int)
  • Tumourlysis syndrome in choriocarcinoma is a rare complication as it is in solid tumours. (oatext.com)
  • Extragonadal choriocarcinomas are rare tumours which are difficult to diagnose. (annalsofafricansurgery.com)
  • In tetsicles it is a rare form of Choriocarcinoma. (cancerworld.info)
  • We report an extremely rare case of choriocarcinoma arising 23 years after menopause. (biomedcentral.com)
  • Association of HG with choriocarcinoma is rare, and in only one reported case 1 the diagnosis was confirmed using direct immunofluorescence. (jamanetwork.com)
  • Choriocarcinoma is a form of cancer that occurs in the female reproductive system. (buzzle.com)
  • Immunohistochemistry tests were positive for β-human chorionic gonadotrophin as well as cytokeratin and negative for octamer binding transcription factor 3/4 and α-fetoprotein, supporting the diagnosis of choriocarcinoma. (biomedcentral.com)
  • By reporting this case and reviewing the literature, we support the opinion of a recent similar case report that the incidence of placental choriocarcinoma may actually be higher than expected, as placental examination after a normal spontaneous delivery is not routinely performed at most of the institutions. (biomedsearch.com)
  • We report on a 32-year-old woman, gravida 5, para 2 who presented with a rapidly growing process of a choriocarcinoma after spontaneous birth. (oatext.com)
  • A few choriocarcinomas arise in sites outside the reproductive organs. (thefreedictionary.com)
  • Choriocarcinoma hardly grows outside the reproductive organs and are usually found in males. (cancerworld.info)
  • Choriocarcinoma involves a high possibility of intratumoral fatal hemorrhage, so a radical operation is recommended as soon as possible 1) . (operativeneurosurgery.com)
  • Sakurada K, Kayama T, Kawakami K, Saino M, Sato S. [A successfully operated case of choriocarcinoma with recurrent intratumoral hemorrhage]. (operativeneurosurgery.com)
  • Spreading of Choriocarcinoma to the intestinal tract may also be related with chronic blood loss and anemia or hemorrhage. (cancerworld.info)
  • Women who have had choriocarcinomas often go on to have normal pregnancies and deliveries. (thefreedictionary.com)
  • According to revealed statistics Choriocarcinoma occurs in 1 out of every 40,000 pregnancies. (cancerworld.info)