A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.
Tumors or cancer of the UTERUS.
Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.
A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).
The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Retinoic acid stimulates the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. (1/568)

The syncytiotrophoblasts of the human placenta express high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the enzyme responsible for the inactivation of glucocorticoids. It has been proposed that the placental 11beta-HSD2 serves as a barrier to protect the fetus from high levels of maternal cortisol. To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts, we investigated the effects of retinoic acids (RAs), the major metabolites of vitamin A, on the expression of 11beta-HSD2 using human choriocarcinoma JEG-3 cells as a model. This trophoblast-like cell line displays a number of functional similarities to the syncytiotrophoblast. Treatment for 24 h with all-trans RA (1-1000 nM) resulted in a dose-dependent increase in 11beta-HSD2 activity with a maximal effect (increase to 3-fold) at 100 nM. The effect of all-trans RA (100 nM) was also time-dependent in that the effect was detectable at 6 h and reached its maximum by 48 h. Similar increases in 11beta-HSD2 activity were observed when the cells were treated with 9-cis RA. Results from semi-quantitative reverse transcription-polymerase chain reaction demonstrated that there was a corresponding increase in 11beta-HSD2 mRNA after RA treatment. Moreover, treatment with actinomycin D (100 ng/ml) abrogated the increase in 11beta-HSD2 mRNA induced by RA, indicating an effect on transcription. In conclusion, the present study has demonstrated for the first time that RA, at physiological concentrations, induces 11beta-HSD2 gene expression and enzyme activity in JEG-3 cells. If this occurs in vivo, the present finding suggests that high expression of 11beta-HSD2 in the human placenta may be maintained, at least in part, by dietary intake of vitamin A.  (+info)

CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. (2/568)

The CD9 molecule is expressed on human extravillous trophoblasts, which invade the endometrium during implantation and placentation. To elucidate the role of CD9 in trophoblastic function, we investigated the expression of CD9 protein and mRNA in BeWo cells, a human trophoblast-like choriocarcinoma cell line, using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). When BeWo cells were cultured with anti-CD9 monoclonal antibodies (mAb), their invasion through the extracellular matrices was significantly enhanced in a dose-dependent manner. Cell proliferation and human chorionic gonadotrophin production were unaffected. On the other hand, culture in the presence of mAb against integrins alpha3, alpha5 and beta1, which partially block the interaction with the extracellular matrices, inhibited BeWo cell invasion. Anti-CD9 monoclonal antibody had a stimulatory effect on BeWo cell invasion in the presence of anti-integrin alpha3 antibody. In contrast, it had no effect in the presence of mAb against integrins alpha5 and beta1, which were also highly expressed on BeWo cells. These findings suggest that CD9 has a function connected with the invasive properties of BeWo cells, which is partially mediated by integrin alpha5beta1. This may relate to the involvement of CD9 in trophoblastic invasion.  (+info)

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. (3/568)

BACKGROUND: The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy. MATERIALS AND METHODS: We have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines. RESULTS: Inhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53. CONCLUSIONS: The MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.  (+info)

The presentation and management of post-partum choriocarcinoma. (4/568)

Post-partum choriocarcinoma is a rare complication of pregnancy. We have analysed a series of nine consecutive patients presenting with choriocarcinoma after a full-term non-molar pregnancy. All patients were managed at the Supraregional Trophoblastic Disease Screening and Treatment Centre at Weston Park Hospital, Sheffield between 1987 and 1996. All presented with persistent primary or secondary post-partum haemorrhage. Treatment with multiagent chemotherapy (initially methotrexate, dactinomycin and etoposide) was successful in all cases. Early diagnosis is important because this rare condition is potentially curable with appropriate chemotherapy.  (+info)

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. (5/568)

Human chorionic gonadotropin (hCG) exhibits molecular heterogeneity in both its protein and carbohydrate moieties. This communication describes changes in hCG isoforms detected directly in clinical samples. These isoforms, quantified in blood or urine specimens, show a progression of change throughout normal pregnancy. Early pregnancy produces a type of hCG that resembles, in terms of immunoreactivity, a major form of hCG excreted in choriocarcinoma. The isoforms predominate for the first 5-6 weeks of gestation and then diminish, being replaced with the hCG isoforms which predominate throughout the remainder of pregnancy. The alteration in hCG isoform content occurs in both blood and urine. The progression of isoforms is best delineated by calculating the change in the ratio of the two forms, as many hCG assays either do not detect or fail to discriminate among these isoforms. An analogous pattern of hCG isoforms was observed in patients with in vitro fertilization pregnancies. hCG isolated from the pituitary displayed binding characteristics similar to those of the hCG derived from normal pregnancy urine. The early pregnancy hCG isoforms appear to have a differential expression in normal pregnancy as opposed to pregnancies which will not carry to term, suggesting that a determination of the relative balance of hCG isoforms may have diagnostic application in predicting pregnancy outcome.  (+info)

Comparison of mechanisms mediating uptake and efflux of thyroid hormones in the human choriocarcinoma cell line, JAR. (6/568)

We compared the specificities of transport mechanisms for uptake and efflux of thyroid hormones in cells of the human choriocarcinoma cell line, JAR, to determine whether triiodothyronine (T3), thyroxine (T4) and reverse T3 (rT3) are carried by the same transport mechanism. Uptake of 125I-T3, 125I-T4 and 125I-rT3 was saturable and stereospecific, but not specific for T3, T4 and rT3, as unlabelled L-stereoisomers of the thyroid hormones inhibited uptake of each of the radiolabelled hormones. Efflux of 125I-T3 was also saturable and stereospecific and was inhibited by T4 and rT3. Efflux of 125I-T4 or 125I-rT3 was, in contrast, not significantly inhibited by any of the unlabelled thyroid hormones tested. A range of compounds known to interfere with receptor-mediated thyroid hormone uptake in cells inhibited uptake of 125I-T3 and 125I-rT3, but not 125I-T4. We conclude that in JAR cells uptake and efflux of 125I-T3 are mediated by saturable and stereospecific membrane transport processes. In contrast, the uptake, but not the efflux, of 125I-T4 and 125I-rT3 is saturable and stereospecific, indicating that uptake and efflux of T4 and rT3 in JAR cells occur by different mechanisms. These results suggest that in JAR cells thyroid hormones may be transported by at least two types of transporters: a low affinity iodothyronine transporter (Michaelis constant, Km, around 1 microM) which interacts with T3, T4 and rT3, but not amino acids, and an amino acid transporter which takes up T3, but not T4 or rT3. Efflux of T4 and rT3 appears to occur by passive diffusion in these cells.  (+info)

Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (7/568)

Human placental trophoblast is critically involved in mediating maternal tolerance of the fetal semiallograft. Genes encoding highly polymorphic major histocompatibility complex (MHC) class I and class II antigens that could provoke maternal immune rejection responses are silenced in trophoblast. However, several MHC class I or class I-related products exhibiting reduced or negligible polymorphism are expressed and assumed to be functionally involved in maintaining pregnancy. The CD1 gene family encodes non-polymorphic MHC class I-like products that have the unusual ability to present non-peptide antigens to T cells. One member, CD1D, is expressed in certain epithelial cells and interacts with a specific T-cell subset that may promote the development of Th2-mediated responses believed to be associated with pregnancy. In this study we examined the expression of CD1D in human trophoblast cell lines and placentally derived trophoblast cells by reverse transcriptase-polymerase chain reaction using CD1D-specific oligonucleotide primers. We have found that CD1D mRNA transcripts are expressed in trophoblast cells and cell lines. We have also identified a novel alternatively spliced CD1D mRNA transcript lacking exon 4. Exon 4-intact and exon 4-deficient CD1D transcripts appear to be differentially expressed in different trophoblast and non-trophoblast cell populations. Our studies suggest that at least one member of the CD1 family is transcribed in human trophoblast.  (+info)

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (8/568)

We have cloned the human Na+-dependent multivitamin transporter (SMVT), which transports the water-soluble vitamins pantothenate, biotin, and lipoate, from a placental choriocarcinoma cell line (JAR). The cDNA codes for a protein of 635 amino acids with 12 transmembrane domains and 4 putative sites for N-linked glycosylation. The human SMVT exhibits a high degree of homology (84% identity and 89% similarity) to the rat counterpart. When expressed in HRPE cells, the cDNA-induced transport process is obligatorily dependent on Na+ and accepts pantothenate, biotin, and lipoate as substrates. The relationship between the cDNA-specific uptake rate of pantothenate or biotin and Na+ concentration is sigmoidal with a Na+:vitamin stoichiometry of 2:1. The human SMVT, when expressed in Xenopus laevis oocytes, induces inward currents in the presence of pantothenate, biotin, and lipoate in a Na+-, concentration-, and potential-dependent manner. We also report here on the structural organization and chromosomal localization of the human SMVT gene. The SMVT gene is approximately 14 kilobase pairs in length and consists of 17 exons. The SMVT gene is located on chromosome 2p23 as evidenced by somatic cell hybrid analysis and fluorescence in situ hybridization.  (+info)

Choriocarcinoma is a rare type of cancer that develops in the placenta, which is the tissue that nourishes a developing fetus during pregnancy. It is a highly aggressive form of cancer that can spread quickly to other parts of the body, including the lungs, brain, and liver. Choriocarcinoma is most commonly diagnosed in women who have had a molar pregnancy, which is a pregnancy in which the placenta produces too much of a hormone called human chorionic gonadotropin (hCG). It can also occur in women who have had previous pregnancies or who have certain genetic conditions. Treatment for choriocarcinoma typically involves chemotherapy, which is used to kill cancer cells. In some cases, surgery or radiation therapy may also be used. The prognosis for choriocarcinoma depends on several factors, including the stage of the cancer at diagnosis, the patient's overall health, and the response to treatment. With early detection and appropriate treatment, the prognosis for choriocarcinoma is generally good.

Choriocarcinoma, non-gestational, is a rare type of cancer that develops in the tissue that normally forms the lining of the uterus during pregnancy. This type of cancer can occur in women who have never been pregnant or who have had a miscarriage, ectopic pregnancy, or molar pregnancy. It can also occur in men and in rare cases, in children. Choriocarcinoma, non-gestational, is highly aggressive and can spread quickly to other parts of the body, including the lungs, liver, and brain. It is typically diagnosed through a combination of imaging tests, such as ultrasound and CT scans, and blood tests that measure the level of human chorionic gonadotropin (hCG), a hormone that is produced by the placenta during pregnancy. Treatment for choriocarcinoma, non-gestational, typically involves chemotherapy, which is used to kill cancer cells and shrink tumors. In some cases, surgery or radiation therapy may also be used. The prognosis for choriocarcinoma, non-gestational, depends on several factors, including the stage of the cancer at the time of diagnosis and the patient's overall health. However, with prompt and aggressive treatment, many people with this type of cancer can be cured.

Uterine neoplasms refer to abnormal growths or tumors that develop in the uterus, which is the female reproductive organ responsible for carrying and nourishing a developing fetus during pregnancy. These neoplasms can be benign (non-cancerous) or malignant (cancerous) in nature. Benign uterine neoplasms include leiomyomas (fibroids), adenomyosis, and endometrial polyps. These conditions are relatively common and often do not require treatment unless they cause symptoms such as heavy bleeding, pain, or pressure on other organs. Malignant uterine neoplasms, on the other hand, are less common but more serious. The most common type of uterine cancer is endometrial cancer, which develops in the lining of the uterus. Other types of uterine cancer include uterine sarcomas, which are rare and aggressive tumors that develop in the muscle or connective tissue of the uterus. Diagnosis of uterine neoplasms typically involves a combination of physical examination, imaging studies such as ultrasound or MRI, and biopsy. Treatment options depend on the type, size, and location of the neoplasm, as well as the patient's overall health and age. Treatment may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Hydatidiform mole is a type of abnormal pregnancy that occurs when a fertilized egg fails to develop properly and instead forms a mass of abnormal tissue. This tissue is called a mole because it is made up of small, cyst-like structures called hydatid cysts. Hydatidiform moles are usually detected during a routine ultrasound exam, and they are often referred to as "pregnancy tumors." They are not true tumors, however, but rather a type of abnormal growth that occurs in the uterus. Hydatidiform moles can be classified as complete or partial. A complete hydatidiform mole occurs when the abnormal tissue contains all four sets of chromosomes, which is the same as the number found in a normal human egg. A partial hydatidiform mole occurs when the tissue contains only two sets of chromosomes, which is half the number found in a normal human egg. Hydatidiform moles are usually treated by surgical removal of the tissue. In some cases, chemotherapy may also be used to treat the mole. It is important to note that hydatidiform moles can be associated with an increased risk of developing certain types of cancer, such as gestational trophoblastic disease, so close follow-up with a healthcare provider is important.

Trophoblastic neoplasms are a group of rare tumors that arise from the cells that form the placenta during pregnancy. These tumors can be either benign or malignant, and they can occur in women of any age, although they are most common in women who are pregnant or have recently given birth. There are two main types of trophoblastic neoplasms: hydatidiform mole and choriocarcinoma. Hydatidiform mole is a benign tumor that is caused by the abnormal development of the placenta. Choriocarcinoma, on the other hand, is a malignant tumor that can spread to other parts of the body if left untreated. Trophoblastic neoplasms are typically diagnosed through a combination of physical examination, imaging studies, and blood tests. Treatment options for these tumors depend on the type and stage of the tumor, as well as the woman's overall health. In some cases, surgery may be necessary to remove the tumor, while in other cases, chemotherapy or radiation therapy may be used to shrink the tumor or kill cancer cells.

Hydatidiform mole, invasive is a type of abnormal pregnancy that occurs when a fertilized egg fails to develop properly and instead forms a mass of abnormal tissue. This tissue is called a hydatidiform mole, and it can invade the uterine wall (invasive hydatidiform mole) or spread to other parts of the body (chorionic carcinoma). Invasive hydatidiform mole is a serious condition that requires prompt medical attention. It is typically treated with surgery to remove the affected tissue, followed by chemotherapy to kill any remaining cancer cells. If left untreated, invasive hydatidiform mole can lead to serious complications, including uterine cancer, high blood pressure, and anemia. It is important to note that hydatidiform mole is different from a molar pregnancy, which is a type of abnormal pregnancy that occurs when a fertilized egg develops normally but the placenta does not. Molar pregnancies can also be invasive, but they are less common than hydatidiform mole.

Gestational Trophoblastic Disease (GTD) is a group of rare but potentially life-threatening conditions that occur during pregnancy or after the end of pregnancy. GTD is characterized by the abnormal growth of cells that form the placenta, called trophoblasts. There are several types of GTD, including: 1. Hydatidiform mole: This is the most common type of GTD and occurs when the fertilized egg does not develop properly, resulting in abnormal growth of the placenta. 2. Choriocarcinoma: This is a rare and aggressive type of cancer that develops from the trophoblast cells. 3. Placental site trophoblastic tumor: This is a rare type of GTD that occurs when the placenta does not completely detach from the uterus after birth or miscarriage. 4. Persistent trophoblastic disease: This occurs when the placenta does not completely detach from the uterus after birth or miscarriage, and the abnormal cells continue to grow and spread. GTD can cause symptoms such as vaginal bleeding, abdominal pain, and high levels of human chorionic gonadotropin (hCG) in the blood. Treatment for GTD depends on the type and stage of the disease, and may include surgery, chemotherapy, or radiation therapy. Early detection and treatment are crucial for a good prognosis.

Chorionic Gonadotropin, beta Subunit, Human (hCG beta) is a hormone that is produced by the placenta during pregnancy. It is a subunit of the larger hormone chorionic gonadotropin (hCG), which is responsible for maintaining the corpus luteum and supporting pregnancy. In the medical field, hCG beta is often used as a diagnostic tool to confirm pregnancy. It is typically measured in a blood or urine sample using a pregnancy test. A high level of hCG beta in the blood or urine indicates that a woman is pregnant. hCG beta is also used in some fertility treatments, such as in vitro fertilization (IVF), to stimulate ovulation and support the growth of the embryo. It is also used in some cancer treatments, such as in the treatment of testicular cancer, to monitor the effectiveness of the treatment and to detect any recurrence of the cancer. Overall, hCG beta is an important hormone in the field of reproductive medicine and is used in a variety of diagnostic and therapeutic applications.

Chorionic Gonadotropin (hCG) is a hormone produced by the placenta during pregnancy. It is responsible for maintaining the corpus luteum, which produces progesterone to support the pregnancy. hCG is also used as a diagnostic tool in medicine to detect pregnancy, as well as to monitor the progress of the pregnancy and detect any potential complications. In some cases, hCG may also be used to treat certain medical conditions, such as certain types of cancer.

Glycoprotein hormones, alpha subunit are a group of hormones that are composed of two subunits: an alpha subunit and a hormone-specific beta subunit. The alpha subunit is a common component of several different glycoprotein hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The alpha subunit is encoded by a single gene and is synthesized in the pituitary gland. It is then cleaved from the larger glycoprotein hormone molecule, leaving behind the hormone-specific beta subunit. The alpha subunit is responsible for binding to specific receptors on the surface of target cells, allowing the hormone-specific beta subunit to exert its effects. Glycoprotein hormones, alpha subunit are important regulators of various physiological processes, including growth and development, metabolism, and reproduction. They are often used as diagnostic markers in medical testing and are also used in the treatment of various medical conditions, such as infertility and thyroid disorders.

Testicular neoplasms refer to tumors or abnormal growths that develop in the testicles, which are the male reproductive organs responsible for producing sperm and testosterone. These neoplasms can be either benign (non-cancerous) or malignant (cancerous), and they can occur in either one or both testicles. Testicular neoplasms are relatively rare, but they are one of the most common types of cancer in young men between the ages of 15 and 35. The most common type of testicular cancer is germ cell tumors, which account for about 95% of all testicular cancers. Other types of testicular neoplasms include Leydig cell tumors, Sertoli cell tumors, and teratomas. Symptoms of testicular neoplasms may include a painless lump or swelling in the testicle, a feeling of heaviness or discomfort in the scrotum, or a change in the size or shape of the testicle. If left untreated, testicular cancer can spread to other parts of the body, including the lymph nodes, lungs, and liver. Diagnosis of testicular neoplasms typically involves a physical examination of the testicles, as well as imaging tests such as ultrasound or CT scans. A biopsy may also be performed to confirm the presence of cancer cells. Treatment for testicular neoplasms depends on the type and stage of the cancer. Options may include surgery to remove the affected testicle or part of the testicle, chemotherapy to kill cancer cells, or radiation therapy to shrink tumors. In some cases, watchful waiting may be recommended for small, slow-growing tumors that are not likely to cause harm.

Stage I choriocarcinoma Stage 2 choriocarcinoma Stage 3 choriocarcinoma Stage 4 choriocarcinoma "choriocarcinoma" at Dorland's ... Elements of choriocarcinoma in a mixed testicular tumor have no prognostic importance. Choriocarcinomas can also occur in the ... The same is true of choriocarcinoma arising in the ovary. Testicular choriocarcinoma has the worst prognosis of all germ-cell ... Choriocarcinoma of the placenta during pregnancy is preceded by: hydatidiform mole (50% of cases) spontaneous abortion (20% of ...
Vaginal bleeding is a common symptom of gestational choriocarcinoma. In the event the gestational choriocarcinoma has already ... and potential of recurring gestational choriocarcinoma. Gestational choriocarcinoma (GC) is the most aggressive form of ... Gestational choriocarcinoma can happen during and after any type of pregnancy event, though risk of the disease is higher in ... If the choriocarcinoma has metastasized to the lungs, one of the most common organs of metastasis, then symptoms may include ...
As of 2020, the reported incidence of choriocarcinoma ranges from 1 in 40 000 pregnancies in North America and Europe, to 9.2 ... "Choriocarcinoma: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2020-12-17. Ngan HY, Seckl MJ, Berkowitz RS, ... The exact pathogenesis of choriocarcinoma has not been fully understood, but studies have shown cytotrophoblast cells function ... Bishop BN, Edemekong PF (2020). "Choriocarcinoma". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30571055. ...
Magrath, I. T.; Golding, P. R.; Bagshawe, K. D. (1971-06-12). "Medical Presentations of Choriocarcinoma". British Medical ...
Li, MC; Hertz, R; Spencer, DB (1956). "Effect of methotrexate upon choriocarcinoma". Proc Soc Exp Biol Med. 93 (2): 361-366. ... Li MC, Hertz R, Bergenstal DM (July 1958). "Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and ... Roy Hertz and Min Chiu Li then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956, ... discovering that methotrexate alone could cure choriocarcinoma (1958), a germ-cell malignancy that originates in trophoblastic ...
Choriocarcinoma, for example, is an uncommon, yet almost always curable cancer. Although choriocarcinoma is a highly malignant ... Sometimes it may develop into an invasive mole, or, more rarely into a choriocarcinoma. A choriocarcinoma is likely to spread ... The treatment for invasive mole or choriocarcinoma generally is the same. Both are usually treated with chemotherapy. ... "Persistent trophoblastic disease and choriocarcinoma". nhs.uk. 2017-10-19. Retrieved 2021-02-16. van Trommel NE, Massuger LF, ...
... and choriocarcinoma; clinical and microscopical analysis (20 min; color). PMF 5316 (1957) - The Effect of Ionizing Radiation on ...
Akingba JB, Ayodeji EA (February 1966). "Amenorrhea as a leading symptom of choriocarcinoma". The Journal of Obstetrics and ...
Akingba JB, Ayodeji EA (February 1966). "Amenorrhea as a leading symptom of choriocarcinoma". The Journal of Obstetrics and ...
Li XN, Li YL, Liu GB, Ding YQ (Jan 2005). "Selection of choriocarcinoma-associated genes using bioinformatics". Di 1 Jun Yi da ...
... of women who developed choriocarcinoma died within a year. Today, with chemotherapy, choriocarcinoma can be cured in almost ... Yarris, Jonathan P; Hunter, Alan J (1 May 2003). "Roy Hertz, M.D. (1909-2002): The cure of choriocarcinoma and its impact on ... Within four months she was "normal without evidence of disease." Li treated two additional patients with choriocarcinoma that ... Li, M. C.; Hertz, R.; Spencer, D. B. (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". ...
A molar pregnancy and choriocarcinoma can provoke it. In some people, it persists long-term. It is associated with premature ...
Min Chiu Li and his collaborators then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956 ... Hertz R, Li MC, Spencer DB (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". ... and choriocarcinoma and other trophoblastic neoplasms. Although originally designed as a chemotherapy drug, in lower doses ...
Surgically removed choriocarcinomas from human patients also exhibited a heavily methylated H19 promoter with enhanced H19 ... Choriocarcinomas, in contrast to adrenal carcinomas, have upregulated H19 and downregulated IGF2 expression. The upregulated ... In cell lines derived from human choriocarcinomas, Kopf et al. found that transcription of H19 was under the simultaneous ... to suggest that in cases of choriocarcinomas, the H19 promoter was mutated, allowing it to overcome the transcriptional ...
They are decreased with toxemia, choriocarcinoma, and Placental insufficiency. The placenta and fetus may be regarded as a ...
... migration and invasion of choriocarcinoma". Carcinogenesis. 32 (5): 765-71. doi:10.1093/carcin/bgr033. PMID 21325635. Li Y, ...
Masse, R. J.; Shaw, P. J.; Burgess, M. (2008). "Intracranial choriocarcinoma causing precocious puberty and cured with combined ...
Angiomatous (vascular) type : This is the most common type of choriocarcinoma. It is distinguished by the presence of numerous ...
1957: The first cancer, choriocarcinoma, was cured with chemotherapy at NCI. 1960: NCI began funding government-supported ...
Hayakawa K, Takahashi M, Sasaki K, Kawaoi A, Okano T (January 1977). "Primary choriocarcinoma of the lung: case report of two ... Under light microscopy, the giant malignant pleomorphic cells making up a GCCL resemble those found in choriocarcinoma, ... GCCL and primary pulmonary choriocarcinoma can also be differentiated on the basis of ultrastructural features by electron ... a critical distinction to be made because while there is a known standard of care for treating choriocarcinoma, as yet there is ...
Choriocarcinoma are trophoblastic tumors that form in the uterus from villous cells. Trophoblast stem cells (TSCs) are cells ...
Kato N, Shimotohno K, VanLeeuwen D, Cohen M (August 1990). "Human proviral mRNAs down regulated in choriocarcinoma encode a ... Another functional role is suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. "Human ... but not in choriocarcinoma tumor cells". Journal of Cellular Biochemistry. 36 (2): 121-8. doi:10.1002/jcb.240360203. PMID ... "Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma". International Journal of Cancer. 41 ...
It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible ... a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15-25. doi:10.1016/ ... "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The ...
Duffy L, Zhang L, Sheath K, Love DR, George AM (December 2015). "The Diagnosis of Choriocarcinoma in Molar Pregnancies: A ... In 2 to 3% of cases, hydatidiform moles may develop into choriocarcinoma, which is a malignant, rapidly growing, and metastatic ... In contrast, incomplete moles can become invasive as well but are not associated with choriocarcinoma. Notably, complete ... of developing into choriocarcinoma and a higher risk of 10-15% in Eastern countries, with an additional 15% risk of becoming an ...
Results from this study further indicate that activities of this enzyme vary among the different choriocarcinoma cell lines and ... Chou JY, Robinson JC (July 1977). "Induction of placental alkaline phosphatase in choriocarcinoma cells by 5-bromo-2′- ... choriocarcinoma cells were grown in the presence of 5-bromo-2'-deoxyuridine and results conveyed a 30- to 40-fold increase in ...
"Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells". Journal of ...
Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can ... Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ...
"Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells". Proc. Natl. Acad. ...
Choriocarcinoma of the testicles has the worst prognosis of all germ-cell cancers. Embryonic stem cells Cancer research Maoz A ... This kind of mixed germ cell tumor may be known simply as a teratoma with elements of embryonal carcinoma or choriocarcinoma, ... Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or ... embryonal carcinoma and/or choriocarcinoma. They can present in the anterior mediastinum.[citation needed] Some investigators ...
Ovarian hyperstimulation occurs more often with invasive moles and choriocarcinoma than complete molar pregnancies. A widely ...
Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy. ... Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). They may also occur after an ...
Pure choriocarcinoma of the testis is the exception to most of the rules established for testicular seminoma and all other ... Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with ... Choriocarcinoma is not uncommonly a component of NSGCTs. [1] Pure choriocarcinoma of the testis is one of the least common but ... Like other germ cell tumors (GCTs), choriocarcinoma typically affects younger men. Unlike other such cancers, choriocarcinoma ...
"Choriocarcinoma" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Shah AM, Tidswell M, Prefontaine M, Skiest DJ, Pantanowitz L. Choriocarcinoma in an AIDS patient--relapsing but not fatal. Int ... This graph shows the total number of publications written about "Choriocarcinoma" by people in this website by year, and ... Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON- ...
choriocarcinoma answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, ... "Choriocarcinoma." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Nursing Central, nursing.unboundmedicine.com/ ... nursingcentral/view/Tabers-Dictionary/751213/0/choriocarcinoma. Choriocarcinoma. In: Venes DD, ed. Tabers Medical Dictionary. ... Choriocarcinoma [Internet]. In: Venes DD, editors. Tabers Medical Dictionary. F.A. Davis Company; 2021. [cited 2023 October 02 ...
Choriocarcinoma occurs in about 1 in 20,000 to 40,000 pregnancies in the United States and three to nine per 40,000 pregnancies ... Clinical presentation of choriocarcinoma depends on the extent of disease and location of metastases. The most frequent sites ... Conclusion Choriocarcinoma is a rare disease. Patients should be managed by a gynaecologist oncologist and/or medical ... Introduction/Background Choriocarcinoma is the most aggressive histologic type of gestational trophoblastic neoplasia (GTN). It ...
Fertility-Sparing Treatment in Gestational Choriocarcinoma: Evaluating Oncological and Obstetrical Outcomes... Med Sci Monit In ...
... ; Synonyms: RA 1 Cells,Ramos (RA 1) Cells,Ramos 1 Cells,Ramos-RA1 Cells; find -CB_85030802 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Histologically, it is classified into hydatidiform mole, invasive mole (chorioadenoma destruens), choriocarcinoma, and ... Hepatic metastases of choriocarcinoma: a report of 15 patients. Gynecol Oncol. 1986 Sep. 25(1):73-83. [QxMD MEDLINE Link]. ... Trends in gestational choriocarcinoma: a 27-year perspective. Obstet Gynecol. 2003 Nov. 102(5 Pt 1):978-87. [QxMD MEDLINE Link] ... Choriocarcinoma and gestational trophoblastic disease. Obstet Gynecol Clin North Am. 2005 Dec. 32(4):661-84. [QxMD MEDLINE Link ...
Choriocarcinoma in children. Shitara T, Oshima Y, Yugami S, Sotomatu M, Kuroume T, Shibasaki T, Matsuyama S. Shitara T, et al. ...
Testicular Choriocarcinoma * 2002284288-overviewDiseases & Conditions. Diseases & Conditions Extrapulmonary Small Cell ...
Rare tumor of the ovary: Primitive choriocarcinoma (Articles) Sanâa Errarhay, Najia Hmidani, Samia Mahmoud, Hind El Fatemi, ...
Choriocarcinoma is a rare neoplasm, which is commonly treated with chemotherapy. However, in some cases, it is managed by ... Choriocarcinoma with Uterine Rupture in a Patient with Confirmed COVID-19 Infection: A Rare Case Report ... We present the case of a 34-year-old woman with choriocarcinoma, complicated by uterine rupture after the first course of ... Here, we present a rare case of uterine rupture associated with choriocarcinoma in a patient with COVID-19 infection. ...
choriocarcinoma. *testicular teratoma. * testicular epidermoid (teratoma with ectodermal elements only). *burned out testis ...
... choriocarcinoma and hydatidiform mole, and in these cases urines often required 1/200 dilution (5). Choriocarcinoma was first ... Gestational choriocarcinoma (GC) is rare and occurs in 1/20-50,000 pregnancies, according to conflicting studies, but prior to ... Therapy of choriocarcinoma and related trophoblastic tumours with folic acid and purine antagonists. New Engl J Med 1958; 259: ...
1993) A case of testicular choriocarcinoma achieving pathological complete response by "COMPE" chemotherapy, consisting of ... and choriocarcinomas (Ohno et al., 1993). MTX is also used in the treatment of nonneoplastic diseases, such as psoriasis ( ...
Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma ...
Pineal Region Tumors - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
If malignant, report as Choriocarcinoma (9100/3, ) malignancy code in the C00- C97 range. ...
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... the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma ... the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma ...
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and ... Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and ...
... and choriocarcinoma. Manually Curated. * bone disease (ISS) ...
Choriocarcinoma, no ICD-O subtype Active Synonym false false 2973133019 Choriocarcinoma, no International Classification of ... Choriocarcinoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality). Concept Status. ... Choriocarcinoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality). Code System ...
Distinct genomic profiles of gestational choriocarcinoma, a unique cancer of pregnant tissues. Jung Seung-Hyun, et al. ... Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma. Miyai Kosuke, et al ... tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma. He ...
Nongestational choriocarcinoma. Mixed germ cell tumor, specify components. Biphasic or triphasic teratomas ...
choriocarcinoma, dermoid, dysgerminoma, embryonal carcinoma, endodermal sinus tumor, EGGCT, extradonadel & germ cell tumors, ...
choriocarcinoma, dermoid, dysgerminoma, embryonal carcinoma, endodermal sinus tumor, EGGCT, extradonadel & germ cell tumors, ...
JAr human choriocarcinoma cells; human neural progenitor cells. Studies of viral gene expression in response to SOCS1 or SOCS3 ...
  • Choriocarcinoma is a type of gestational trophoblastic disease . (medlineplus.gov)
  • Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL). (umassmed.edu)
  • Introduction/Background Choriocarcinoma is the most aggressive histologic type of gestational trophoblastic neoplasia (GTN). (bmj.com)
  • Fertility-Sparing Treatment in Gestational Choriocarcinoma: Evaluating Oncological and Obstetrical Outcomes. (medscimonit.com)
  • Smith HO, Kohorn E, Cole LA. Choriocarcinoma and gestational trophoblastic disease. (medscape.com)
  • In 1929, Aschheim (using the A-Z bioassay) reported greatly elevated urine hCG results in two forms of gestational trophoblastic disease (GTD), choriocarcinoma and hydatidiform mole, and in these cases urines often required 1/200 dilution (5). (ibms.org)
  • Gestational choriocarcinoma (GC) is rare and occurs in 1/20-50,000 pregnancies, according to conflicting studies, but prior to the 1950s treatment was limited to surgery and radiation and the prognosis was poor. (ibms.org)
  • About one half of all women with a choriocarcinoma had a hydatidiform mole, or molar pregnancy. (medlineplus.gov)
  • Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with testicular seminoma constitute the two major histologic groups of testicular cancers. (medscape.com)
  • Like other germ cell tumors (GCTs), choriocarcinoma typically affects younger men. (medscape.com)
  • In a histologic review of 1010 orchiectomies from 1999 to 2011 from a single Mexican oncology institution, 0.6% were pure choriocarcinomas and 0.9% were mixed germ cell tumors with a predominant choriocarcinoma component. (medscape.com)
  • In a literature review of 10,000 cases of germinal testicular cell tumors, Ramon y Cajal et al found 54 (0.5%) cases of pure choriocarcinoma. (medscape.com)
  • Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). (umassmed.edu)
  • Choriocarcinoma recapitulates placental tissue development. (medscape.com)
  • In a series of 125 patients with a history or clinical evidence of cryptorchidism and testis tumor, 3 (2%) were pure choriocarcinoma, which is similar to the overall incidence of choriocarcinoma among GCTs. (medscape.com)
  • Choriocarcinoma is a fast-growing cancer that occurs in a woman's uterus (womb). (medlineplus.gov)
  • Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. (medlineplus.gov)
  • Choriocarcinoma occurs in about 1 in 20,000 to 40,000 pregnancies in the United States and three to nine per 40,000 pregnancies in Southeast Asia and Japan. (bmj.com)
  • Unlike other such cancers, choriocarcinoma metastasizes hematogenously, and bleeding from metastatic sites is characteristic. (medscape.com)
  • En 11 annees (1er janvier 1998-31 decembre 2008) 9946 patientes ont ete operes dans notre servie dont 29 pour le cancer de l'ovaire soit 0;29. (bvsalud.org)
  • Early diagnosis of choriocarcinoma can improve the outcome. (medlineplus.gov)
  • Conclusion Choriocarcinoma is a rare disease. (bmj.com)
  • A choriocarcinoma may come back within a few months to 3 years after treatment. (medlineplus.gov)
  • Laboratory studies in patients with pure choriocarcinomas typically show marked elevation in beta-human chorionic gonadotropin levels. (medscape.com)
  • This graph shows the total number of publications written about "Choriocarcinoma" by people in this website by year, and whether "Choriocarcinoma" was a major or minor topic of these publications. (umassmed.edu)
  • Choriocarcinoma was first described in Germany by Hans Chiari in 1877 with histological studies reported by M Saengers (1889) and six years later by Felix Marchand (6). (ibms.org)
  • [ 1 ] Pure choriocarcinoma of the testis is one of the least common but most aggressive forms of NSGCTs. (medscape.com)
  • In a 2008 review of GCTs in 50 men older than 60 years, only one was found to have a component of choriocarcinoma. (medscape.com)
  • The incidental finding of a choriocarcinoma confined to the placenta with no evidence of dissemination to the mother, or infant is the least common scenario. (medscape.com)
  • Her placenta revealed intraplacental choriocarcinoma. (medscape.com)
  • 2. Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole. (nih.gov)
  • 8. [Incidental intraplacental gestational choriocarcinoma on a full-term placenta]. (nih.gov)
  • 15. Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature. (nih.gov)
  • Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo. (nih.gov)
  • In this study, we investigated the effects of two polybrominated diphenyl ethers (PBDEs), two hydroxylated PBDEs, and 2,4,6-tribromophenol (2,4,6-TBP) on TH SULT activity in a choriocarcinoma placenta cell line (BeWo). (nih.gov)
  • Choriocarcinoma is a type of gestational trophoblastic disease . (medlineplus.gov)
  • Ramon y Cajal S, Pinango L, Barat A. Metastatic pure choriocarcinoma of the testis in an elderly man. (medscape.com)
  • Puri S, Sood S, Mohindroo S, Kaushal V. Cytomorphology of lung metastasis of pure choriocarcinoma of testis in a 58-year-old male. (medscape.com)
  • Pure choriocarcinoma of the testis is the exception to most of the rules established for testicular seminoma and all other forms of NSGCTs. (medscape.com)
  • In a series of 125 patients with a history or clinical evidence of cryptorchidism and testis tumor, 3 (2%) were pure choriocarcinoma, which is similar to the overall incidence of choriocarcinoma among GCTs. (medscape.com)
  • In a literature review of 10,000 cases of germinal testicular cell tumors, Ramon y Cajal et al found 54 (0.5%) cases of pure choriocarcinoma. (medscape.com)
  • the oldest patient with a pure choriocarcinoma was 63 years old. (medscape.com)
  • Of all forms of gestational choriocarcinoma, placental choriocarcinoma is the most rare. (medscape.com)
  • Due to the potential fatal outcome of placental choriocarcinoma, careful evaluation of both mother and infant after the diagnosis is made is important. (medscape.com)
  • The incidence of placental choriocarcinoma may actually be higher than expected since it is not routine practice to send placentas for pathological evaluation after a normal spontaneous delivery. (medscape.com)
  • The obstetrician, pathologist, and pediatrician should have an increased awareness of placental choriocarcinoma and its manifestations. (medscape.com)
  • Of all forms of gestational choriocarcinoma, placental choriocarcinoma is the most rare and is usually diagnosed in symptomatic patients with metastases. (medscape.com)
  • Cite this: Incidental Placental Choriocarcinoma in a Term Pregnancy: A Case Report - Medscape - Oct 16, 2008. (medscape.com)
  • 5. Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. (nih.gov)
  • Chen X, Xu L, Chen X, Teng X, Zheng S. Testicular choriocarcinoma metastatic to skin and multiple organs. (medscape.com)
  • Elkeeb D, Hopkins Z, Florell SR. Pure testicular choriocarcinoma presenting as a friable hemorrhagic nodule on the lip. (medscape.com)
  • Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with testicular seminoma constitute the two major histologic groups of testicular cancers. (medscape.com)
  • Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. (medscape.com)
  • Rejlekova K, Cursano MC, De Giorgi U, Mego M. Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome. (medscape.com)
  • Like other germ cell tumors (GCTs), choriocarcinoma typically affects younger men. (medscape.com)
  • In a histologic review of 1010 orchiectomies from 1999 to 2011 from a single Mexican oncology institution, 0.6% were pure choriocarcinomas and 0.9% were mixed germ cell tumors with a predominant choriocarcinoma component. (medscape.com)
  • Choriocarcinoma is a malignant form of GTN that forms either from hydatidliform moles, miscarriage or ectopic pregnancy. (cumedicine.us)
  • A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. (bvsalud.org)
  • 1. [Intraplacental choriocarcinoma]. (nih.gov)
  • 6. Intraplacental choriocarcinoma: a case report. (nih.gov)
  • 11. Biochemical analysis of intraplacental choriocarcinoma and fetomaternal transfusion. (nih.gov)
  • 16. A case of intraplacental choriocarcinoma associated with placental hemangioma. (nih.gov)
  • 17. Intraplacental choriocarcinoma associated with pregnancy continuum: a diagnostic dilemma. (nih.gov)
  • 19. Ectopic choriocarcinoma masquerading as a persisting pregnancy of unknown location: case report and review of the literature. (nih.gov)
  • 14. Cerebral venous sinus thrombosis presenting as cerebral metastasis in a patient with choriocarcinoma following a non-molar gestation. (nih.gov)
  • Maternal choriocarcinoma is usually diagnosed in symptomatic patients with metastases. (medscape.com)
  • 10. Maternal and neonatal death from advanced choriocarcinoma due to a delay in diagnosis: a case report. (nih.gov)
  • 20. [Infantile and maternal choriocarcinoma]. (nih.gov)
  • NaUCC-2, a choriocarcinoma cell line, was derived from a patient who had a very poor clinical response to combination chemotherapy. (nih.gov)
  • These findings also suggest that the most commonly used combination chemotherapy for choriocarcinoma, dactinomycin and MTX, may not always be the best method. (nih.gov)
  • Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). (medlineplus.gov)
  • Choriocarcinoma and the very rare PSTT and ETT can follow any type of pregnancy. (isuog.org)
  • In most reports, choriocarcinoma carries a dismal prognosis due to its early hematogenous spread. (medscape.com)
  • Choriocarcinomas spread from the muscle layer of the uterus to nearby blood vessels and often beyond, to the brain, lungs, kidneys and vagina. (cumedicine.us)
  • 7. Choriocarcinoma presenting as an intussusception--a case report. (nih.gov)
  • In a 2008 review of GCTs in 50 men older than 60 years, only one was found to have a component of choriocarcinoma. (medscape.com)