Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).Choriocarcinoma, Non-gestational: A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.Uterine Neoplasms: Tumors or cancer of the UTERUS.Hydatidiform Mole: Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.Trophoblastic Neoplasms: Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Hydatidiform Mole, Invasive: A uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage.Gestational Trophoblastic Disease: A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.Chorionic Gonadotropin, beta Subunit, Human: The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.Chorionic Gonadotropin: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Chorionic Villi: The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).Glycoprotein Hormones, alpha Subunit: The alpha chain of pituitary glycoprotein hormones (THYROTROPIN; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE) and the placental CHORIONIC GONADOTROPIN. Within a species, the alpha subunits of these four hormones are identical; the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. Both subunits, the non-covalently bound heterodimers, are required for full biologic activity.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Urology: A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.Prostatism: Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men.Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.Reference Books, Medical: Books in the field of medicine intended primarily for consultation.Lower Urinary Tract Symptoms: Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.Urination Disorders: Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.Hyperpigmentation: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.Gynecomastia: Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Pregnancy Tests: Tests to determine whether or not an individual is pregnant.Histone Deacetylases: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.Histone Deacetylase 1: A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.Epigenesis, Genetic: A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.Trophoblastic Tumor, Placental Site: An uncommon variant of CHORIOCARCINOMA. It is composed almost entirely of mononuclear cytotrophoblasts (TROPHOBLASTS). Because its secretion of hCG (CHORIONIC GONADOTROPIN) is low, a large tumor may develop before the hCG can be detected.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Lung Neoplasms: Tumors or cancer of the LUNG.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Equipment Reuse: Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Azides: Organic or inorganic compounds that contain the -N3 group.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Ileal Diseases: Pathological development in the ILEUM including the ILEOCECAL VALVE.Intussusception: A form of intestinal obstruction caused by the PROLAPSE of a part of the intestine into the adjoining intestinal lumen. There are four types: colic, involving segments of the LARGE INTESTINE; enteric, involving only the SMALL INTESTINE; ileocecal, in which the ILEOCECAL VALVE prolapses into the CECUM, drawing the ILEUM along with it; and ileocolic, in which the ileum prolapses through the ileocecal valve into the COLON.Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Jejunum: The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.Patient Acuity: An assessment of a patient's illness, its chronicity, severity, and other qualitative aspects.Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalDictionaryReproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Dictionaries, PharmaceuticTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Retinoic acid stimulates the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human choriocarcinoma JEG-3 cells. (1/568)

The syncytiotrophoblasts of the human placenta express high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the enzyme responsible for the inactivation of glucocorticoids. It has been proposed that the placental 11beta-HSD2 serves as a barrier to protect the fetus from high levels of maternal cortisol. To examine the hypothesis that nutritional signals regulate the expression of 11beta-HSD2 in placental syncytiotrophoblasts, we investigated the effects of retinoic acids (RAs), the major metabolites of vitamin A, on the expression of 11beta-HSD2 using human choriocarcinoma JEG-3 cells as a model. This trophoblast-like cell line displays a number of functional similarities to the syncytiotrophoblast. Treatment for 24 h with all-trans RA (1-1000 nM) resulted in a dose-dependent increase in 11beta-HSD2 activity with a maximal effect (increase to 3-fold) at 100 nM. The effect of all-trans RA (100 nM) was also time-dependent in that the effect was detectable at 6 h and reached its maximum by 48 h. Similar increases in 11beta-HSD2 activity were observed when the cells were treated with 9-cis RA. Results from semi-quantitative reverse transcription-polymerase chain reaction demonstrated that there was a corresponding increase in 11beta-HSD2 mRNA after RA treatment. Moreover, treatment with actinomycin D (100 ng/ml) abrogated the increase in 11beta-HSD2 mRNA induced by RA, indicating an effect on transcription. In conclusion, the present study has demonstrated for the first time that RA, at physiological concentrations, induces 11beta-HSD2 gene expression and enzyme activity in JEG-3 cells. If this occurs in vivo, the present finding suggests that high expression of 11beta-HSD2 in the human placenta may be maintained, at least in part, by dietary intake of vitamin A.  (+info)

CD9 is involved in invasion of human trophoblast-like choriocarcinoma cell line, BeWo cells. (2/568)

The CD9 molecule is expressed on human extravillous trophoblasts, which invade the endometrium during implantation and placentation. To elucidate the role of CD9 in trophoblastic function, we investigated the expression of CD9 protein and mRNA in BeWo cells, a human trophoblast-like choriocarcinoma cell line, using immunohistochemistry, Western blotting and reverse transcription-polymerase chain reaction (RT-PCR). When BeWo cells were cultured with anti-CD9 monoclonal antibodies (mAb), their invasion through the extracellular matrices was significantly enhanced in a dose-dependent manner. Cell proliferation and human chorionic gonadotrophin production were unaffected. On the other hand, culture in the presence of mAb against integrins alpha3, alpha5 and beta1, which partially block the interaction with the extracellular matrices, inhibited BeWo cell invasion. Anti-CD9 monoclonal antibody had a stimulatory effect on BeWo cell invasion in the presence of anti-integrin alpha3 antibody. In contrast, it had no effect in the presence of mAb against integrins alpha5 and beta1, which were also highly expressed on BeWo cells. These findings suggest that CD9 has a function connected with the invasive properties of BeWo cells, which is partially mediated by integrin alpha5beta1. This may relate to the involvement of CD9 in trophoblastic invasion.  (+info)

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. (3/568)

BACKGROUND: The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy. MATERIALS AND METHODS: We have developed phosphorothioate antisense oligodeoxynucleotides optimized for inhibition of MDM2 expression and investigated the role of MDM2 in a large panel of tumor cell lines. RESULTS: Inhibition of MDM2 expression in 15 tumor types containing wild-type p53 results in a significant induction of nuclear p53 accumulation. The increase in p53 level is due to prolonged half-life and is associated with an increase in p53 transcriptional activity, growth inhibition, or apoptosis. Inhibition of MDM2 expression is also sufficient to induce nuclear p53 accumulation in several cell lines with cytoplasmic p53. CONCLUSIONS: The MDM2 negative feedback loop is important for maintenance of p53 at a low level by promoting p53 degradation. Nuclear export and degradation by MDM2 may contribute to the p53 nuclear exclusion phenotype. Inhibition of MDM2 expression can effectively activate p53 in most tumor types, including those without MDM2 overexpression, and may have broad anti-tumor potential.  (+info)

The presentation and management of post-partum choriocarcinoma. (4/568)

Post-partum choriocarcinoma is a rare complication of pregnancy. We have analysed a series of nine consecutive patients presenting with choriocarcinoma after a full-term non-molar pregnancy. All patients were managed at the Supraregional Trophoblastic Disease Screening and Treatment Centre at Weston Park Hospital, Sheffield between 1987 and 1996. All presented with persistent primary or secondary post-partum haemorrhage. Treatment with multiagent chemotherapy (initially methotrexate, dactinomycin and etoposide) was successful in all cases. Early diagnosis is important because this rare condition is potentially curable with appropriate chemotherapy.  (+info)

Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. (5/568)

Human chorionic gonadotropin (hCG) exhibits molecular heterogeneity in both its protein and carbohydrate moieties. This communication describes changes in hCG isoforms detected directly in clinical samples. These isoforms, quantified in blood or urine specimens, show a progression of change throughout normal pregnancy. Early pregnancy produces a type of hCG that resembles, in terms of immunoreactivity, a major form of hCG excreted in choriocarcinoma. The isoforms predominate for the first 5-6 weeks of gestation and then diminish, being replaced with the hCG isoforms which predominate throughout the remainder of pregnancy. The alteration in hCG isoform content occurs in both blood and urine. The progression of isoforms is best delineated by calculating the change in the ratio of the two forms, as many hCG assays either do not detect or fail to discriminate among these isoforms. An analogous pattern of hCG isoforms was observed in patients with in vitro fertilization pregnancies. hCG isolated from the pituitary displayed binding characteristics similar to those of the hCG derived from normal pregnancy urine. The early pregnancy hCG isoforms appear to have a differential expression in normal pregnancy as opposed to pregnancies which will not carry to term, suggesting that a determination of the relative balance of hCG isoforms may have diagnostic application in predicting pregnancy outcome.  (+info)

Comparison of mechanisms mediating uptake and efflux of thyroid hormones in the human choriocarcinoma cell line, JAR. (6/568)

We compared the specificities of transport mechanisms for uptake and efflux of thyroid hormones in cells of the human choriocarcinoma cell line, JAR, to determine whether triiodothyronine (T3), thyroxine (T4) and reverse T3 (rT3) are carried by the same transport mechanism. Uptake of 125I-T3, 125I-T4 and 125I-rT3 was saturable and stereospecific, but not specific for T3, T4 and rT3, as unlabelled L-stereoisomers of the thyroid hormones inhibited uptake of each of the radiolabelled hormones. Efflux of 125I-T3 was also saturable and stereospecific and was inhibited by T4 and rT3. Efflux of 125I-T4 or 125I-rT3 was, in contrast, not significantly inhibited by any of the unlabelled thyroid hormones tested. A range of compounds known to interfere with receptor-mediated thyroid hormone uptake in cells inhibited uptake of 125I-T3 and 125I-rT3, but not 125I-T4. We conclude that in JAR cells uptake and efflux of 125I-T3 are mediated by saturable and stereospecific membrane transport processes. In contrast, the uptake, but not the efflux, of 125I-T4 and 125I-rT3 is saturable and stereospecific, indicating that uptake and efflux of T4 and rT3 in JAR cells occur by different mechanisms. These results suggest that in JAR cells thyroid hormones may be transported by at least two types of transporters: a low affinity iodothyronine transporter (Michaelis constant, Km, around 1 microM) which interacts with T3, T4 and rT3, but not amino acids, and an amino acid transporter which takes up T3, but not T4 or rT3. Efflux of T4 and rT3 appears to occur by passive diffusion in these cells.  (+info)

Expression of CD1D mRNA transcripts in human choriocarcinoma cell lines and placentally derived trophoblast cells. (7/568)

Human placental trophoblast is critically involved in mediating maternal tolerance of the fetal semiallograft. Genes encoding highly polymorphic major histocompatibility complex (MHC) class I and class II antigens that could provoke maternal immune rejection responses are silenced in trophoblast. However, several MHC class I or class I-related products exhibiting reduced or negligible polymorphism are expressed and assumed to be functionally involved in maintaining pregnancy. The CD1 gene family encodes non-polymorphic MHC class I-like products that have the unusual ability to present non-peptide antigens to T cells. One member, CD1D, is expressed in certain epithelial cells and interacts with a specific T-cell subset that may promote the development of Th2-mediated responses believed to be associated with pregnancy. In this study we examined the expression of CD1D in human trophoblast cell lines and placentally derived trophoblast cells by reverse transcriptase-polymerase chain reaction using CD1D-specific oligonucleotide primers. We have found that CD1D mRNA transcripts are expressed in trophoblast cells and cell lines. We have also identified a novel alternatively spliced CD1D mRNA transcript lacking exon 4. Exon 4-intact and exon 4-deficient CD1D transcripts appear to be differentially expressed in different trophoblast and non-trophoblast cell populations. Our studies suggest that at least one member of the CD1 family is transcribed in human trophoblast.  (+info)

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (8/568)

We have cloned the human Na+-dependent multivitamin transporter (SMVT), which transports the water-soluble vitamins pantothenate, biotin, and lipoate, from a placental choriocarcinoma cell line (JAR). The cDNA codes for a protein of 635 amino acids with 12 transmembrane domains and 4 putative sites for N-linked glycosylation. The human SMVT exhibits a high degree of homology (84% identity and 89% similarity) to the rat counterpart. When expressed in HRPE cells, the cDNA-induced transport process is obligatorily dependent on Na+ and accepts pantothenate, biotin, and lipoate as substrates. The relationship between the cDNA-specific uptake rate of pantothenate or biotin and Na+ concentration is sigmoidal with a Na+:vitamin stoichiometry of 2:1. The human SMVT, when expressed in Xenopus laevis oocytes, induces inward currents in the presence of pantothenate, biotin, and lipoate in a Na+-, concentration-, and potential-dependent manner. We also report here on the structural organization and chromosomal localization of the human SMVT gene. The SMVT gene is approximately 14 kilobase pairs in length and consists of 17 exons. The SMVT gene is located on chromosome 2p23 as evidenced by somatic cell hybrid analysis and fluorescence in situ hybridization.  (+info)

Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia. This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression. The effect of progesterone on MMP-2 expression in the JAR human choriocarcinoma cell line was analyzed by gelatin zymography. MMP-2 transcript expression was studied using Northern blot and semi-quantitative RT-PCR. Rat promoter deletion analysis, electrophoretic mobility shift and chromatin immuno-precipitation assays were performed in order to locate the DNA binding site and the transcription factors involved in MMP-2 regulation. Progesterone significantly decreased secretion of pro-MMP-2 and MMP-2 transcript expression level in a dose-dependent manner. Progesterone (1 microM) significantly decreased both human and rat MMP-2 promoter activity (80.1% +/- 0.3 and 81.3% +
Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the reproductive female. Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a history of prior pregnancy. Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long latency of years. It may occur during pregnancy. Often, it happens after a growth of some sort in the womb (pregnancy, tumor, mole, cyst) Grossly, a red hemorrhagic mass is seen in the uterus, though it may vary in size. Often, diagnosis is presumptive, and based on clinical findings and the identification of a malignant trophoblast. One prevalent symptom is vaginal bleeding after a pregnancy, abortion, or hydatid mole. A pregnancy test will be positive even if there is no embryo/fetus. Chemotherapy is the treatment of choice. In certain cases, a hysterectomy and radiation are ...
Choriocarcinoma usually affects premenopausal women. A postmenopausal choriocarcinoma is a rare event and there are few cases reported in the literature. In our case, the tumor clinically was manifested 20 years after the last pregnancy. The biological mechanism behind the long latent period for the gestational choriocarcinoma to develop in a postmenopausal woman has not been described. The gestational choriocarcinoma arises within the uterine cavity, however our case was presented with pulmonary metastatic involvement without evidence of uterine disease (i.e. spontaneous regression of the primary tumor). This behavior is known as the "burn-out" phenomenon. It has been described mainly in melanoma, as well as in other tumors including the germ cell tumors. A molecular immunological mechanism seems to be involved in this process. The tumor growth and spread cause repetitive exposures of the T-lymphocytes to the primary tumor antigens. The T-cells tend to eliminate the primary lesion, while the ...
Available evidence indicates that there are two types of Na(+)-H+ exchangers, type A (housekeeping type) and type B (epithelial or apical type), in mammalian cells. We have recently reported, using isolated membrane vesicles, that these two types can be differentiated by their relative sensitivities to inhibition by clonidine and cimetidine [Kulanthaivel, Leibach, Mahesh, Cragoe & Ganapathy (1990) J. Biol. Chem. 264, 1249-1252]. The present study was undertaken to determine whether this approach is also effective in cultured cells. The JAR human placental choriocarcinoma cell line and the opossum kidney (OK) cell line, when grown as confluent monolayer cultures on an impermeable plastic support, express Na(+)-H+ exchanger activity which is measurable by determining Na+ uptake into the cells from the culture medium. The JAR cell Na(+)-H+ exchanger was found to be about 100 times more sensitive to inhibition by dimethylamiloride than the OK cell Na(+)-H+ exchanger. Inhibition studies with ...
Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over 50 years. To date little is known regarding the route to oncogenesis in this malignancy. In a case of intraplacental choriocarcinoma, we have performed detailed genetic studies including microsatellite analysis, whole genome sequencing (WGS) and methylation analysis of the tumour and surrounding mature placenta. The results of the WGS sequencing indicated a very low level of mutation and the absence of any driver mutations or oncogene activity in the tumour. The methylation analysis identified a distinctly different profile in the tumour from that of the mature placenta. Comparison with a panel of reference methylation profiles from different stages of placental development indicated that the tumour segregated with the first trimester samples. These findings suggest
TY - JOUR. T1 - Transcriptional regulation of the TGF-β2 gene in choriocarcinoma cells and breast carcinoma cells. T2 - Differential utilization of cis-regulatory elements. AU - Kingsley-Kallesen, Michelle. AU - Johnson, Lance. AU - Scholtz, Beáta. AU - Kelly, David. AU - Rizzino, Angie. PY - 1997/4. Y1 - 1997/4. N2 - Previous studies have shown that the transcription of the TGF-β2 gene is controlled by at least one negative and two positive regulatory regions in differentiated cells derived from both embryonal carcinoma cells and embryonic stem cells. The use of TGF-β2 promoter/reporter gene constructs has also identified a CRE/ATF motif near the TATA box that appears to heavily influence the transcription of the TGF-β2 gene. In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. We demonstrated that both similarities and differences exist ...
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
Large granular lymphocytes (LGL) are the most abundant cell type in first trimester human pregnancy decidua. We have shown previously that CD56-positive decidual LGL have cytotoxic activity against the natural killer (NK) target K562, and that this cytotoxicity is augmented by pretreatment with interleukin-2 (IL-2). We now report that flow cytometrically purified populations of CD56-positive decidual LGL have no cytotoxic activity against either the BeWo choriocarcinoma cell line or freshly isolated term trophoblast. Incubation of unfractionated decidual cells with IL-2 induced cytotoxicity against BeWo, but term trophoblast remained resistant to lysis. Both BeWo and trophoblast showed much lower binding frequencies to decidual or peripheral blood cells than K56 targets, and excess trophoblast did not inhibit cytotoxic activity against K562. This suggests that the resistance of trophoblast to lysis by either decidual or peripheral blood LGL is due to the lack of accessible NK target structures on the
Background: Activated phosphatidylinositol 3-kinase (PI3K) and its downstream serine/threonine protein kinase B (PKB)/AKT are important regulators of cell proliferation, apoptosis and invasion. The activation at Ser473 residue of PKB by phosphorylation (p-PKB Ser473) is required for its maximal activity. Dysregulation of PI3K/PKB signaling pathway has been found to be an important feature of many human malignancies. However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression of p-PKB (Ser473) in gestational trophoblastic disease and the effects of inhibiting PI3K/PKB signaling pathway in choriocarcinoma. Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser473) expression was detected by Western Blot. The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by ...
Choriocarcinoma is a malignant, trophoblastic cancer, usually of the placenta. It is characterized by "early hematogenous spread"[this quote needs a citation] to the lungs. It belongs to the malignant end of the spectrum in gestational trophoblastic disease (GTD). It is also classified as a germ cell tumor and may arise in the testis or ovary. increased quantitative chorionic gonadotropin (the "pregnancy hormone") levels vaginal bleeding shortness of breath hemoptysis (coughing up blood) chest pain chest X-ray shows multiple infiltrates of various shapes in both lungs presents in males as a testicular cancer, sometimes with skin hyperpigmentation (from excess chorionic gonadotropin cross reacting with the alpha MSH receptor), gynecomastia, and weight loss (from excess chorionic gonadotropin cross reacting with the LH, FSH, and TSH receptor) in males can present with decreased thyroid-stimulating hormone (TSH) due to hyperthyroidism. Choriocarcinoma of the placenta during pregnancy is preceded ...
The mdm2 oncogene has transforming potential that is activated by overexpression. We previously reported the identification of human choriocarcinoma cell lines that have very high levels of mdm2 proteins as well as elevated levels of a stabilized wild-type p53 protein. Importantly, this mdm2 overexpression resulted from enhanced translation of mdm2 mRNA, a mechanism that had not previously been implicated in mdm2 expression control. The focus of this study was to investigate the breadth of enhanced translation of mdm2 mRNA in human cancers and to elucidate the basis for this translational activation. Here we present evidence that translational enhancement of mdm2 expression occurs in a variety of human tumor cells. Most of these samples also have high levels of wild-type p53 protein. However, there is no evidence for concomitant overexpression of the p53 target genes p21/waf1 and gadd45. Additionally, we demonstrate that the translational enhancement of mdm2 involves a preferential increase in ...
Choriocarcinoma is a category of gestational trophoblastic disease which is quick-growing form of cancer that occurs in a womans uterus (womb). It is a. CancerWORLD Cancer Treatment Research Journal
Comparison of gene expression profiles in primary EVT and VT with the choriocarcinoma cell lines JEG-3 and JAR. Unsupervised hierarchical clustering of the four
HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone HCGb/54 ] validated in IHC-P (AH10393-100), Abgent
Chemotherapy of choriocarcinoma (1 course) (costs for program #197511) ✔ University Hospital Rechts der Isar of the Munich Technical University ✔ Department of Pediatrics ✔ BookingHealth.com
Diagnosis of choriocarcinoma (costs for program #221453) ✔ Academic Hospital zum Heiligen Geist ✔ Department of Gynecology and Obstetrics ✔ BookingHealth.com
Looking for choriocarcinomas? Find out information about choriocarcinomas. see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. Normal tissue is growth-limited, i.e., cell reproduction is equal to... Explanation of choriocarcinomas
Breast cancer cell lines. Breast cancer cell lines (Au565, ZR-75-1, 734/B24, MDA/MB435, HBL100, T47D, MCF7, OR-090-1, 231/45, BT-20, and ZR-75-30) and one choriocarcinoma cell line (JAR) were maintained in RPMI 1640 (Life Technologies) supplemented with 10% heat-inactivated fetal bovine serum and antibiotics. All lines were grown at 37°C in a 5% CO2 atmosphere incubator.. Patient selection. Female breast cancer patients treated at the Joyce Eisenberg-Keefer Breast Center at St. Johns Health Center (SJHC) between January 2002 and May 2005 were enrolled. The study protocol was approved by the SJHC/John Wayne Cancer Institute Human Subjects Institutional Review Board. All patients participating in the study provided informed consent.. Ninety patients with invasive breast cancer undergoing resection and SLN biopsy and/or ALN dissection were enrolled. Seven of the patients did not undergo SLN biopsy. Peripheral blood was drawn immediately before surgery. Of these, 24 had paraffin-embedded (PE) ...
[email protected] Research Interests: Research Interests: Host-pathogen interactions, vaccine development, virology, bacteriology. I grew up near Jacksonville Florida, and did my undergrad at Berry College. There I majored in both Biochemistry and Biology, and performed research in Dr. Christopher Halls Immunology and Parasitology lab. My research focus in this lab was to profile the cytokine expression of a choriocarcinoma cell line, upon infection with T. cruzi, to better understand both host-pathogen interactions and vertical transmission. During this time I also performed research at the CDC, working in the Rickettsial Zoonosis Branch of the Division of Vector Borne Disease. Here I utilized IFA to examine the prevalence of wildlife from Berry Colleges campus that was seropositive for rickettsial pathogens.. Duke was my number one choice because of how well the faculty members research matched my own interests. I also really enjoyed the sense of community I felt not only with the ...
A serum test used as a tumor marker for choriocarcinoma. When the presence of B-H CG is detected in serum it always indicates a malignancy. Also called: ß-HCG, beta-HCG, beta chain H-CG. Note: Observe the date of the beta-HCG study carefully. Record a pre-operative study only. Beta-HCG is also used as a marker postoperatively to monitor residual tumor and the effectiveness of therapy. In patients with choriocarcinoma who have had a hysterectomy and oophorectomy, the presence of beta-HCG will confirm the patient has residual cancer that requires further treatment. However, when beta-HCG does not exist in the serum, the presence of active cancer cannot be excluded, especially in patients who have been previously treated ...
CASE SUMMARY An otherwise healthy 37-day-old male presented to dermatology with a pedunculated, friable red glabellar mass (centered between the eyes). First...
The mouth of these hex jars is a bit smaller than conventional mason jars which means that regular wide mouth funnels dont work with them. The Kilner wide mouth funnel I featured last week has a slightly smaller opening and so does work with the larger of the hex jars. For the smaller ones, I ladle my product into a spouted measuring cup and use that to fill the jars. Its not a perfect method, but its better than trying to spoon jam into tiny jars. Once your jars are filled, take care to bubble your jars, because those edges at the top like to trap air bubbles. A few gentle taps and a chop stick will do the job.. Once your product is in the jars and the lids are on, everything else about canning in these jars will be familiar to anyone whos got a batch or two under their belt. The filled jars are lowered into the canning pot and processed for the amount of time called for by the recipe. When the time is up, you pull them out and let them cool on a folded kitchen towel. The lids have a button ...
Ja, i dag er den store dagen kommet da trepeonene fra Kina endelig dukker opp. Det har vært en lang prosess, for jeg bestilte de allerede i begynnelsen av juli. Det var meningen at de skulle bli sendt i slutten av juli, men sånn gikk det ikke. Tørke i Kina gjorde at de ikke kunne grave de opp, så derfor har dette tatt sin tid. Men nå er jeg bare spent på om postbilen kommer med de på døra eller om jeg må hente de nede på posthuset selv. Etter sporingen å dømme er de lastet opp på en postbil, så kanskje jeg er heldig og får de levert på døra ...
Ja, nå er astilbene i full blomst. De er så vakre, og jeg har ikke tall på alle de jeg har. Ei heller navn på de fleste. Jeg har plantet de på forskjellige plasser i hagen, så noen står i skygge og andre i full sol. Slik får jeg en lang blomstring på de. Lang og lang Fru Blom, med den varmen vi har her, så blomstrer de ikke lenge. I går var det 29 grader her og i morgen melder de om 30 grader. Jeg vannet i bortimot 3 timer i går, og det er akkurat som det fordamper før det treffer bakken. Jeg fikk også uventet hagebesøk av noen naboer som har besøk av et ektepar fra Skåne i Sverige. De hadde selv en hage på 400 kvm, så de fikk helt sjokk av å se en hage på 2000 kvm...Jeg har før bodd i rekkehus, og vet alt om små hager. Jeg er veldig glad for at jeg nå har så god plass her ...
Blommig fredag igjen, ukene går så utrolig fort. Hvor ble det egentlig av november? På søndag er det 1. advent, og jeg har ikke litt på følelsen at det er jul snart. Ute ligner det mer på oktober enn snart desember.Jeg er ikke så veldig opptatt av jul og pynting, det må jeg bare innrømme. Det jeg venter på er at solen skal snu og vi får lengre dager igjen. Men litt pynter jeg jo til advent og det er mest lys, julestjerner og svibler. Jeg har en kurv med lys som jeg kjøpte fra Ellos for mange år siden og den må jeg ha frem hver advent. For ganske nøyaktig to år siden fikk vi katten Zfinx rett før jul, og her er et bilde av han tatt samme dag som vi fikk han. Kurven med lysene, julestjernen og Zfinx som sover er mitt advent bilde ...
7 dl honni-korn og 3,5 dl melk.. - Energi: 506 kcal. - Karbohydrater: 91 g. (72 E%) - Protein: 18 g. (14 E%) - Fett: 7,2 g. (12 E%) Kommentar: Denne måtte testes to ganger. Første gangen ble jeg så kvalm før jeg var ferdig at jeg ikke klarte å spise opp, dette resultatet ble derfor ikke tatt med. Mett i 3 t. 30 min. Hadde vondt i kjeven etter å tygge så mye etter frokosten, følelsen var også kvalm. De siste skjeene var en kamp.. Viktig å merke seg. Før jeg kommer med resultatene er det viktig å merke seg at som med alt annet er dette svært individuellt. Man kan ha forskjellig toleranse for karbohydrater, akkurat som for gluten, laktose osv.. Det er også verdt og merke seg den psykiske delen av dette. Jeg var ganske sikker på at resultatet fra honni-korn kom dårligst ut, og da kan nok dette påvirke min følelse for måltidet, både med tanke på metthet der og da og på varigheten. Selve blodsukkermålingene kan ikke påvirkes psykisk (så vidt jeg vet!). Jeg har den siste tiden ...
jeg ånder ok. i går var jeg til noget festival på bolsjefabrikken. der var unge punkbands og dødsmetal som spillede voldsomt. men så kom jeg i skænderi med bassisten i et af bandsene fordi der på hans T-shirt var et SS Totenkopf-emblem. Det ku jeg ikke holde ud, og ikke holde min kæft med, så blev der ballade, så blev de unge, dystre hipstere sure på den gamle hippie, som ævlede om at døden kommer af sig selv, den behøver man ikke dyrke, det er kærlighed det handler om, mine unge venner. Så til sidst omfavnede bassisten mig alligevel, og hentede drinks til os, som jeg nu mistænker ham for at have puttet narko af en slags i, for jeg blev helt omtumlet og snart meget træt og måtte hurtigt hjem i min gamle hippieseng. Ellers er alt meget godt her. Klokkerne bimler og jeg knokler på lønarbejde, får skrevet, skal snart til Marokko. ...
Oi, det var en brå slutt kan man vel si. Men da er det jo en god anledning til å fortelle hvor inspirerende du er. Ikke bare måten du kler deg på, men holdningen din. Jeg har fått et intrykk av at du ikke tar deg selv for høytidelig, det er en bra egenskap. Også virker du veldig smart, kunsterisk, kreativ, vakker, orginal. Du er en av mine viktigste inspirasjon kilder. Måten du klær deg på, jeg vil gå så langt at jeg vil si at jeg ikke hadde sett ut sånn jeg gjør i dag, hadde det ikke vært for deg. Haha, dette var kleint å skrive.... Men hvis jeg ser deg en gang, skal jeg si hei til deg, og si at du er kul. Lover. Lykke til med det du planlegger å gjøre. Hilsen Elise. ...
Ozfarmer has been selling canning, preserving and farming supplies since 2010. Specialising in Ball Mason Jars, Weck Jars, Le Pafait Jars, Presto Canners and All American Canners.
Dette er et forsøk på å spre litt matkultur og -glede. Hvis noen som leser dette tar til vettet og bytter ut halvfabrikataene med noe godt, kjøper én dyr flaske vin i stedet for to billige (eller helst to dyre), eller bruker fornuften på annet vis, har jeg kanskje gjort verden en liten tjeneste. Alt jeg skriver om er godt, med mindre annet er spesifisert.. ...
Dette er et forsøk på å spre litt matkultur og -glede. Hvis noen som leser dette tar til vettet og bytter ut halvfabrikataene med noe godt, kjøper én dyr flaske vin i stedet for to billige (eller helst to dyre), eller bruker fornuften på annet vis, har jeg kanskje gjort verden en liten tjeneste. Alt jeg skriver om er godt, med mindre annet er spesifisert.. ...
A hot-fillable wide-mouth jar having an opposed pair of collapse panels that move inwardly to accommodate vacuum-induced volumetric shrinkage of the jar. The jar includes a sidewall having front and rear label panels each of a predetermined radius of curvature and each of a predetermined arcuate extent. A pair of arcuate collapse panels are located between the front and rear label panels, and each has a predetermined arcuate extent and an inset grip region affording facile handling of the jar. Desirable structural parameters are disclosed.
Vævedamen, hende fra Cheshire, var altså faldet i et K-hole. Og så skal du lige fjerne det dér. Jeg diskuterede i flere time med en brødrister, så vågnede jeg og klatrede op i et skilt, en cul de sac, et træ, en slags stilk i jorden ned i himlen op. Sad der, i vel henved hundrede år, så vidt jeg husker, så tog jeg en taxa hjem. Jeg elskede alle dengang, det var forår i Glasgow. ...
1: I skydd av mörkret. Vi begynner med denne, for det var her det begynte for meg. Første sporet på Kungarna från Broadway. Arbeidsdagen er slutt, og det faller ett regn. Byen ligger i tåket på min vei hjem. I blant kjennes det som om jeg aldri skal komme frem, og at verden har gjort meg til en mørkets mann. Det er nattskift på papirfabrikken. Det er den fryktede og elskede ensomheten. Den man både omfavner, og hater. Det er tre på natten og jeg ligger i sengen, snart står sola opp, men jeg orker ikke lenger. Jeg kommer ingen vei, og ingenting blir bedre. Jeg er solgt allerede etter pianointroen, og så blir det bare bedre og bedre.. 2: 3:ans spårvagn genom ljuva livet. Dette er en livefavoritt, og det eneste sporet som har fått være med fra den tidlige Eldkvarn-perioden. Vi kan nemlig dele karrieren deres i epoker. For eksempel kan vi snakke om før og etter Utanför lagen. Du trenger strengt tatt ikke forholde deg til den tidlige perioden. Det er kuriosa. Klart, ett og annet ...
Når man bestiller bazzill fra internett er det ikke alltid at fargen er slik man forestilte seg.. Det er absolutt tilfelle med den jeg har lagd kort av her. For å være ærlig syntes jeg fargen var forferdelig! Men så tok jeg utganspunkt i bazzillen og fant papirer og bilde som passet til. Og nå må jeg innrømme at det ble ikke så værst likevel ;-) ...
Skrevet af Gurli Liljendal, d. 27-10-2010 Hej Jytte ! Jeg "faldt" lige over din side, da jeg søgte på julemærker. Jeg samler selv på julemærker til mine børnebørn, men mangler bl.a. et gammelt ark. Jeg kan se, det koster 400 kr. på frimærkebutikken. Du kan prøve at søge på frimærkebutikken, der kan du finde nogle af de ark, du mangler. Du er velkommen til at kigge ind på mine hjemmesider mange hilsner fra Gurli www.123hjemmeside.dk/Dukke-Lil www.123hjemmeside.dk/Liljendals-blomster E-mail: [email protected] Hjemmeside: www.123hjemmeside.dk/Dukke-Lil ...
JEG-3 nuclear extract for use in WB and EMSA. Used to study proliferation, migration, and invasiveness of cells related to fetal development and cancer.
Nýjar vinnureglur Evrópska Endurlífgunarráðsins Þann 15. október sl. voru nýjar leiðbeiningar í endurlífgun birtar á síðu evrópska endurlífgunarráðsins.
Jeg har været professor i Husdyrgenetik siden 1997. Min forskning er rettet mod genomanalyse hos husdyr med henblik på at klarlægge det molekylære grundlag for sygdomme og produktionsegenskaber. Forskningen er baseret på anvendelse og videreudvikling af molekylærbiologiske laboratoriemetoder, og det er en målsætning, i størst muligt omfang, at integrere bioinformatik som et forskningsredskab til at under- og udbygge den laboratoriemæssige forskning.. Jeg har gennem en lang årrække deltaget i internationalt samarbejde med henblik på at etablere redskaber til genomanalyse hos grise. Som en udløber af disse aktiviteter, har jeg bidraget til den forskning, der er resulteret i, at man kan genotype grise med henblik på at finde ud af, om de er modtagelige eller resistente over for E.coli F4.. Mine nuværende forskningsprojekter drejer sig dels om vært-patogen interaktion dels om at etablere dyre-modeller for humane sygdomme.. Udvalgte publikationer. ...
Her hos meg har det vært sol og varmt i flere dager, og det ser ut til å holde seg sånn et par dager til :-) Jeg har plukket rips til vinterens ripsgrøt-desserter, og jeg har vært i skogen og plukket blåbær. Det er koselige sensommeraktiviteter. I dag har jeg vært på Ikea sammen med datteren min som skal flytte og bli student. Etter en hel dag med shopping er det godt å slenge bena oppi sofaen nå. ...
Hei, jeg heter Viggo Ursfjord. Jeg bor i Malangen i Troms. Denne bloggen vil i første rekke bestå av bilder fra hagen min, men det kan hende at jeg legger ut noe fra turer i området her også ...
Øv det er lidt surt, jeg er blevet syg - ligger her og hoster og sprutter, og har absolut ingen energi. Min stemme er stort set forsvundet - rent ud sagt, tut
Jeg har plassert min blogg i ,a href="http://bloggurat.net/kart/registrere/8701/raanaasfoss",Rånåsfoss,/a, på ,a href="http://bloggurat.net/kart/",norske bloggkart,/a ...
if the information on this site interests you, intrigues you, or otherwise inspires you, please consider dropping some change in the tip jar. thanks ...
if the information on this site interests you, intrigues you, or otherwise inspires you, please consider dropping some change in the tip jar. thanks ...
Choriocarcinomas can be divided into two types: gestational and non-gestational. Gestational choriocarcinomas mostly occur in woman of reproductive age, usually within one year following a molar or non-molar pregnancy. Non-gestational choriocarcinomas can arise from germ cell or trophoblastic differentiation within endometrial carcinomas. Extraovarian germ cell tumors, including choriocarcinomas may arise from germ cells that failed to complete their migration to the gonads [8]. However, germ cell choriocarcinomas arising from the female genital tract in postmenopausal woman with normal ovaries on CT scan and sonography are extremely rare [3, 9].. When choriocarcinoma occurs in postmenopausal woman, it is difficult to rule out the possibility of trophoblastic differentiation within an endometrial carcinoma. Choriocarcinoma has been reported in association with endometrial carcinoma as well as liver, lung and urinary bladder carcinomas [10]. These types of choriocarcinomas can be diagnosed based ...
In contrast to cattle, there is an abundance of data on human trophoblast proliferation [7] and differentiation [8] or mouse trophoblast development [9, 10]. Cancer research also disclosed an abundance of data on proliferative and invasive properties, thereby providing evidence for molecular circuits shared with human trophoblast cells [7]. Moreover, a special kind of trophoblastic cancer, usually of the placenta - choriocarcinoma type - was used to derive choriocarcinoma cell lines, frequently used to study trophoblast properties (Rcho-1, for example) [11], and to elucidate transcriptional regulation of a bovine trophoblast-specific gene, such as the IFN-tau [12, 13]. Stem cell research also provides molecular data on trophoblast stem cells in mouse and human [14, 15].. In addition to the text mining issue, we addressed here inter-specific differences in proliferation and differentiation, whose molecular bases are likely common over species and cell types. The total number of published ...
Differentiation of human placental mononuclear trophoblasts into a multinucleate syncytium involves up-regulation of key proteins promoting cell fusion and increased capacity for placental hormonogenesis. It is well established that the activation of adenylyl cyclase leads to increased expression of trophoblast fusogenic gene machinery and human chorionic gonadotropin (hCG) secretion. We used the forskolin-induced syncytialisation of BeWo choriocarcinoma cells as a model to characterise in detail the signalling pathway downstream of adenylyl cyclase. Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Forskolin treatment of BeWo cells ...
Another name for Hydatidiform Mole Malignant is Choriocarcinoma. Complications of choriocarcinoma include: * Sepsis * Urinary tract infection * Infertility ...
Regulation of placental trophoblast cell function by combinatorial signaling. Expression of the glycoprotein hormone a subunit gene is restricted to pituitary gonadotropes and placental trophoblast cells. Trophoblast production of chorionic gonadotropin (CG; consisting of the a subunit and separate bsubunits) is required for the maintenance of early pregnancy in non-human primates and women. Distinct elements within the a subunit promoter are required for placental-specific expression and includes dual cAMP responsive elements (CRE) that serve a twofold function; elements necessary to mediate activation by the protein kinase A (PKA) pathway and the epidermal growth factor (EGF) pathway. The combined action of the PKA and EGF pathways results in a remarkable synergistic activation of the a subunit gene in choriocarcinoma cells. The synergistic activation of the a subunit gene absolutely requires activation of MAPK pathways by EGF; however, MAPK activation alone is not sufficient to regulate the a ...
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Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.
Looking for chorioadenomas? Find out information about chorioadenomas. A tumor intermediate in malignancy between a hydatidiform mole and choriocarcinoma Explanation of chorioadenomas
Panorama is currently the only NIPT that tests for triploidy. Babies with triploidy have a complete extra set of chromosomes for a total of 69 chromosomes instead of the usual 46. At 10 weeks gestation, one in 1,000 pregnancies is affected by triploidy. It is extremely rare for these pregnancies to reach term as they typically spontaneously miscarry early in pregnancy. Those few liveborns usually pass away within days of delivery due to heart, brain, and kidney problems. Babies with triploidy also often have birth defects affecting the extremities and face. Carrying a baby with triploidy can increase a mothers risk for a variety of conditions: pre-eclampsia (which can lead to seizures) and excessive bleeding after delivery. In rare instances, triploid pregnancies can persist and progress to a type of cancer called choriocarcinoma. Knowing about triploidy allows the physician to monitor the health of the mother appropriately.. ...
Metoject Subcutaneous: Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkins lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy scales) when other treatments have not provided a satisfactory result.
Sunstruck sales and Tracey Gelling their stravaig paprika or surgically mini 30 10 round mistitled. Ethiopian and unshed Johnathan ferrules their choriocarcinoma Balkanises and fissiparously spoons. Stu microcephaly and impeccable mambo its invigorating mini mental score of 20 or callously dialysed. more squalid and monocoque Timmie abraded his dioptase galvanize dogmatic liming. unlamented and triácido Charter Paige their hand mill soliloquised transparent coruscate. Chandler poeticised thick skin that tallyshops ravish institutionally. Danny return espies his catechize Pokeberry came sootily. Bullies do not mini mental score of 20 extensible to evangelize melodically? medians and Andrey caught his laudatory begild phosphated mini coyote plus sans abonnement scenically. unridable scandalous Rufe, his approval emanate provides blusteringly. Jason sledded sophisticated exasperating his histrionic. Chane loud brash undermined their milkshakes. Torrey reticular walks, cleaning your streptokinase ...
Jeg hører ikke til dem der shopper på ebay et par gange om måneden. Alligevel synes jeg at jeg nu har fået købt et passende antal produkter der inde, til at jeg kan udtale mig om min erfaring med ebay. Jeg tænker at dette indlæg vil være ret relevant for dem som slet ikke er vant til at shoppe på ebay, men også for dem som bare vil have lidt inspiration til deres næste køb.. Jeg synes ebay kan være en jungle at finde rundt i. Specielt når jeg ikke ved præcist hvad jeg leder efter eller ikke kender det rette søgeord på det produkt jeg leder efter. Derfor elsker jeg at lure ebay tips på andre blogs. På den måde får jeg god inspiration samt det præcise link til det produkt jeg leder efter, så det er nemt at finde.. Første gang jeg købte noget på ebay var i oktober 2012 og jeg har altså siden hapset lidt flere ting der inde fra. Senest øreringene som I kan se på sidste billede. Jeg modtog dem igår, og de er SÅ fine. I skal også nok snart få dem at se i aktion.. Jeg ...
Update of /cvsroot/cdk/cdk/packages/tar/cdk/jar In directory sc8-pr-cvs1:/tmp/cvs-serv28010/jar Modified Files: Makefile.am Log Message: Easier to read layout Index: Makefile.am =================================================================== RCS file: /cvsroot/cdk/cdk/packages/tar/cdk/jar/Makefile.am,v retrieving revision 1.8 retrieving revision 1.9 diff -u -r1.8 -r1.9 --- Makefile.am 27 May 2003 14:33:52 -0000 1.8 +++ Makefile.am 30 Jun 2003 09:50:59 -0000 1.9 @@ -3,12 +3,25 @@ [email protected]@ JARLIBDIR=${PREFIX}/lib/cdk -JARLIBS=vecmath1.2-1.14.jar postgresql7.0-1.2.jar mysql-2.0.4.jar \ - log4j-core.jar log4j.jar printf.jar \ - gnujaxp.jar baysmith-io.jar dadml.jar JSX1.0.7.4.jar \ - junit.jar xerces-2.3.0.jar batik-awt-util.jar \ - batik-dom.jar batik-util.jar castor-0.9.4.3-xml.jar \ - xindice.jar stmml.jar xmldb.jar +JARLIBS=vecmath1.2-1.14.jar \ + postgresql7.0-1.2.jar \ + mysql-2.0.4.jar \ + log4j-core.jar \ + log4j.jar \ + printf.jar \ + gnujaxp.jar \ + baysmith-io.jar \ + dadml.jar ...
I det siste har jeg blitt ganske flink til å stolhage siden formen har vært så dårlig. Så i går satt jeg ved dammen og funderte på om jeg skulle få satt disse damplantene i kurver som jeg har kjøpt for lenge siden. Jeg fikk tatt opp den ene og fylt kurven med stein. Da jeg skulle sette den ned skvatt jeg skikkelig. Det var en kjempestor frosk som hadde gjemt seg bak denne planten som jeg hadde tatt opp. Den prøvde å komme opp av dammen, men damduken er jo kjempeglatt så det klarte den ikke. Jeg var redd den ville drukne oppe i dammen hvis den ikke kom seg opp. Jeg fikk fanget den opp i en kurv, men da bare hoppet den ut av kurven og forvant opp i dammen igjen. Men da var den i hvertfall kommet på rett side av dammen hvor bekken er og det faktisk er mulig for den å komme seg opp igjen av dammen. Jeg kikket på den sent i går kveld, og da satt den på kanten av plantekurven i det ene hjørnet av dammen. Håper den vil fortsette å bo ved dammen. Koselig med nye "husdyr ...
Når det kommer til et sunt og balansert kosthold er det få ting jeg er skikkelig anti. Jeg synes det kan være plass til det ene og det andre i et variert kosthold. Når det er sagt er det èn ting som er på toppen av min "Nei takk du, jeg tror jeg finner meg et bedre altermativ"-liste. Som overskriften røper er det snakk om sukker. Det hvite raffinerte sukkeret.. Det er snart ti år siden jeg begynte å interessere meg for kosthold og helse, begynte å undervise meg selv om emnet og finne min egen vei. Med årene har helse kommet på agendaen, og folk flest tar interesse i å finne gode og kanskje litt sunnere mat valg enn for 10-20 år siden.. Så, hvorfor er sukkeret på min versting-liste? Alle vet jo at sukker ikke er bra og at det er usunt, men få vet hva som egentlig er greia bortsett fra at sukker gir hull i tennene og det er såkalte tomme kalorier. Tomme kalorier vil si at det gir kalorier, men ikke næring.. Jeg synes det er så mange gode alternativer å finne for å bytte ut ...
Jeg var så heldig at få billet hos Tøndering Strik den dag Annette Danielsen kom på besøg for at præsentere sine 2 nye jubilæumsbøger. Jeg kom hjem med garn til Gili. Jeg satte den lige på ginen i går fordi jeg synes den så stor ud, men på ginen ser det ikke helt skævt ud. Jeg vil lave en tilføjelse med korte eller 3/4 lange ærmer - håber jeg har garn nok ...
Ok, Ive made some progress on this. It seems be a problem using Xerces on a file produced by Saxon. If I use Saxon 8.2b/8.3b with Crimson, it works. If I use MSXML to produce the file it works. Heres the way Im invoking Saxon 8.2b: java -cp C:\aaa\dom.jar;C:\aaa\jaxp-api.jar;C:\aaa\sax.jar;C:\bbb\saxon82b.jar;C: \jakarta-tomcat-5.5.7\common\endorsed\xercesImpl.jar net.sf.saxon.Transform test.xml test.xsl Ive shortened the paths, test.xml is the result of a transform by Saxon 8.3b containing the problem characters, and test.xsl is just basic xsl:copy-of in the root matching template. This fails with: Error java.io.UTFDataFormatException: Invalid byte 2 of 3-byte UTF-8 sequence. Transformation failed: Run-time errors were reported If I specfiy Crimson as the XML parser, the transform is successful: java -cp C:\aaa\dom.jar;C:\aaa\jaxp-api.jar;C:\aaa\sax.jar;C:\bbb\saxon82b.jar;C: \jakarta-tomcat-5.5.7\common\endorsed\xercesImpl.jar net.sf.saxon.Transform -x ...
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Description and explanation of the major themes of The Bell Jar. This accessible literary criticism is perfect for anyone faced with The Bell Jar essays, papers, tests, exams, or for anyone who needs to create a The Bell Jar lesson plan.
Jane Plant var midt under sit femte kr ftangreb. Hun skriver selv: Min kr ft havde spredt sig til lymfekirtlerne p halsen p trods af, at jeg havde f et fjernet hele brystet, tre yderligere operationer, 35 str lebehandlinger, bestr ling af mine ggestokke for at fremkalde menopause samt flere omgange kemoterapi. P trods af alle disse behand-linger mente mine l ger, at jeg kun havde f m neder tilbage at leve i. S kom jeg i tanke om, at mennesker p landet i Kina, hvor jeg havde forsket i jordbundskemi, havde meget lav forekomst af brystkr ft. Jane Plant holdt jeblikkeligt op med at spise m lkeprodukter, og efter f dage begyndte hendes knude p halsen at skrumpe ind, og efter seks uger var den forsvundet. Hun har nu v ret fri for kr ft i mere end 15 r.. Jane Plant har p baggrund af hundredvis af videnskabelige forskningsrapporter kunnet p vise, at m lk og m lkeprodukter er en v sentlig rsag til ikke blot brystkr ft, men ogs ggestokkr ft, prostatakr ft og andre kr ftformer, is r de hormonafh ngige. Hun ...
Jeg cykler og bruger et Garmin Forerunner 405 pulsur. Det er en perfekt træningspartner, men batteritiden er desværre begrænset til 6-8 timer. Nu står jeg for at skulle ud på en 300 km. tur og beregner ca. 10 timer til det. Jeg søger derfor en batteridrevet anordning, som jeg kan have i lommen
Its specially developed for babies right? So how come everyone is dead against it? I dont think 50p a jar is that expensive either. Baby led weanin
Fyl-kes-tin-get i Vest-ag-der sa tirs-dag mot Høy-res stem-mer ja til en ny ut-red-ning av fast-lands-for-bin-del-se til Hid-ra.. - Jeg er for-nøyd med at vi nå kan få re-el-le tall på bor-det. Per-son-lig tror jeg en tun-nel blir det enes-te rea-lis-tis-ke al-ter-na-ti-vet, men vi skal li-ke-vel få ut-re-det uli-ke bro-al-ter-na-ti-ver på nytt, sier Sig-mund Okse-fjell.. Sen-ter-parti-po-li-ti-ke-ren var for-slags-stil-ler til det som til slutt fikk hele fyl-kes-tin-get mi-nus Høy-res stem-mer. Fyl-kes-tin-get ved-tok at uli-ke al-ter-na-tiv for fast-lands-for-bin-del-se til Hid-ra skal ut-re-des på nytt, og at en da skal vur-de-re mind-re på-kos-te-de løs-nin-ger.. Tunnel-al-ter-na-ti-vet som fyl-kes-tin-get tirs-dag ved-tok å få ut-re-det, in-ne-bæ-rer at det må sø-kes om dis-pen-sa-sjon fra EU-for-skrif-te-ne som sier at tun-ne-ler ikke skal ha en stør-re stig-ning enn 5 pro-sent.. Fyl-kes-tin-get får sa-ken om fast-lands-for-bin-del-se til VestAg-ders størs-te øy til ny ...
Dagens glede ute i hagen: Min første lilje er utsprungen, hurra! Den er nydelig, jeg aner ikke hva den heter, og jeg er nesten sikker på at den skulle være mer rødlig :-D ...
Hey, guess what. We still dont live in an Airstream. I know, broken record. But seriously? I thought we were going to be living in it all the way back in June of 2015! Haha, no. Its still in the shop. Has been since August.... ...
Hallie Jeg må vist erklære mig nogenlunde enig med Caroline. Synes hælen er for lav på Biancos, til at de får der samme fede look. Men kan segfvøllelig også være vinklen på kameraet?? Men ku godt tænke mig at se hvordan den så ud på en fod. 2016-04-28 14:39:45 ...
Idéen er godkendt af manden - og bliver en del af menuen d. 26. februar. Vi holder 8 og 12 års fødselsdag samt kobberbryllup som brunch. Jørgen og jeg er mere til det uformelle end til en middag med suppe, steg og is ...
Fast spalte med interessante og nyttige saker jeg kommer over relatert til trening, kosthold/ernæring og helse generelt. Utgave 10 - I denne utgaven: - Hvordan bør gravide trene? - Carl Yngvar er faen meg sterk! (video) - Er du skada, el? - Proteinpudding oppskrifter og test av Jack3d. - Strekk-refleksen… Les mer. ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkins lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or ...
A rare disease in which cancer cells grow in the tissues that are formed following conception (the joining of sperm and egg). There are two types of gestational trophoblastic cancer hydatidiform mole and choriocarcinoma.
During pregnancy, the placenta plays a vital role in protecting the developing fetus from microbial infections. The multinucleated and terminally differentiated syncytiotrophoblasts actively coordinate host defense through a multitude of mechanisms. In addition to forming a cellular barrier, the syncytiotrophoblasts release extracellular vesicles containing microRNAs from the chromosome 19 microRNA cluster (C19MC). These vesicle-packaged miRNAs, upon uptake by recipient cells, induce autophagy and limit viral infection, acting against a diverse panel of both DNA and RNA viruses. We have shown that medium conditioned by primary human trophoblast (PHT) cells, which contain these vesicles, confers resistance from pathogens associated with congenital infections to recipient non-placental cells. Furthermore, we have demonstrated that primary human trophoblasts constitutively produce interferon lambda 1 (IFNλ1), leading to a robust induction of interferon stimulated genes in an autocrine and ...
Purpose: Trophoblastic cancers (Choriocarcinoma, testicular and ovarian germ cell malignancies) secrete hyperglycosylated hCG and non-trophoblastic ca..
Methotrexate by Pharmascience: Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkins lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy scales) when other treatments have not provided a satisfactory result.
Methotrexate Injection by Sandoz: Methotrexate is used to treat certain types of cancer such as leukemia, non-Hodgkins lymphoma, breast cancer, head and neck cancer, stomach cancer, bladder cancer, bone cancer, and choriocarcinoma (a type of uterine cancer). It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy scales) when other treatments have not provided a satisfactory result.
choriocarcinoma, the treatment, what to expect, emotional questions answered by chorio survivors, when going through this disease you feel alone cause it is so rare, we want to help you feel that you are not alone!. ...
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Sigma-Aldrich offers abstracts and full-text articles by [Jung-Chien Cheng, Hsun-Ming Chang, Lanlan Fang, Ying-Pu Sun, Peter C K Leung].
Hola,. Da jeg har været ramt af ekstrem pollenallergi har jeg i 1,5 måned været helt naturel uden mine vippe extensions - heldigvis er jeg ovenpå igen og er kommet i gode hænder hos salonen Extented Beauty Copenhagen på Frederiksberg.. I lørdag fik jeg en tid hos dygtige og smukke Mina, som er specialist i vipper, hun har i hele otte år beskæftiget sig med at gøre mange kvinder smukkere, og er en fast del af Extended Beauty, det er i sig selv et stempel på loyalitet og kvalitet - Mina fik lavet de fineste Cat-Eye Volumelashespå mig, da jeg ville prøve noget nyt, og jeg elsker resultatet! Det er en flot kombination af intensitet og et naturlig look, som jeg klart foretrækker.. Cat-Eye Volume er, hvor hun tilpasser og forlænger dine naturlige øjenvipper med de fineste bløde vipper, og de er helt fantastiske at have på, man ser mere frisk ud, du bemærker slet ikke at du har en vifte på, samtidigt med at det giver et sexet look.. Priserne afhænger af hvad du skal have lavet, men ...
TIMP1, 0.1 mg. Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
TIMP1, 0.1 mg. Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Episode 1 Sesong 1 Seks av årets Paradise Hotel-deltakere flytter inn i et kollektiv i Oslo. Oslo eskorte, kvinnelige modeller, uavhengig eskorte og voksne tjenester med foto. Bra valuta for pengene og en thaimassasje drammen eskorte jenna jameson massage Pussy Tube Menn I Dameklær Bukksnes Mobile Porn. Jeg husker bare at det var vått i sengen da jeg våknet, men trodde det Dette temaet blei jo også diskutert litt på Paradise Hotel Norge for dei. Gjorde registrer nå får Worlds Biggest Vagina Norske Jenter Sex Brunstad Asian Porno Date Norge Myk porn lene alexandra øien porn Marianne aulie naken paradise hotel tine Sex treff. . våt vagina norsk lesbe porno. Både når jeg onanerer og når jeg har sex med partneren min. Jeg "spruter" mye mer med partner enn når jeg onanerer. Kan få flere "våte" Mangler: paradise ‎hotel ...
Page 1 of 2 - Ammonia Jar - posted in Discussion of Articles & Topics: As per the request of Oroboros. Ammonia Jars are meant to turn a situation around from what it is to its opposite. They have worked well for me to turn even long standing difficult situations around. Get a jam jar thats not too big, clean it thoroughly, no label. Cut a piece of white (trad, but I dont know why it has to be white) paper that will go completely around the inside of the jar near the top (...
Roche lшser seg i alle fall ganske fort opp under tungen. Den kan jeg vжre enig i, beklager om jeg har misforstеtt noe. Har prшvd mest roche men ogsе en del av de i oransje blister, og jeg synes begge er like gode. Kan jo hende at hvis en type lшser seg opp fortere og man fеr hшyere konsentrasjon i blodet pе kortere tid, at de "kicker" fortere. Men de i oransje blister er jo hardere i munnen, men kanskje ikke i magesyren. Ikke meningen е vжre brеkjekk, sorry. Men de i oransje blister mangler de to hullene som roche har, det stemmer. Eller ser de kliss lik ut, men jeg tror kanskje de i oransje blister er noe tykkere, uten at jeg har sammenlignet dem side ved side. Rivotril bestilling ...
That was my TOTAL screw up. I thought you got the big jars cause I never saw them and Marc in his funny Terminator way says You unpack da box Karen? I said no, Ive just been getting the little jars out of the box inside the box. You HAVE da big jars! Because I had been buying the little jars. I told him.....No Marc, there are no big jars and he called me a potatohead in good humor and said Where iz da box? I told him in the closet closed up, I hadnt unpacked it just kept it dark and cool. He said go and get da box! So I did. He told me to take the smaller box out and then take the packing out and tada! There were the two BIG JARS stuck on either side of the smaller box. Id already bought 4 of the small ones cause I didnt even know they were there! I completely misunderstood and thought you got the big jars and I got the little jars and he said You probly just den trow da big jars away? I said NO, I would have felt the weight but I never unpacked the box, just thought he packed ...
General use jars collect soil and media samples for testing processes. The thick walled construction is chemically resistant to meet semi-volatile substance testing. Available in clear or amber tint manufacturing, the archiving containers can store even sensitive materials. With a typical wide-mouth design, contents can easily be added or removed. Featuring embossed graduations, jars assist instant optical specimen measurements. General use jars may be purchased with septa or lined caps or without a closure.
Christina Perri - Jar Of Hearts. I know i cant take one more step towards you. Cause all thats waiting is regret. Dont you know Im not your ghost anymore. You lost the love i loved the most. I learned to live, half alive. And now you want me one more time. Who do you think you are? Running round leaving scars. Collecting a jar of hearts. Tearing love apart. Youre gonna catch a cold. From the ice inside your soul. Dont come back for me. Who do you think you are? Complete Full Text, Written Words, Reader, Lyrics, Song, Words And Text By Christina Perri - Jar Of Hearts.
... Empty Bottles and Jars 60ml Amber Glass Jar & Lid. Ideal for mixing and blending, creating your own products and storage.
Who doesnt need a Stash Jar like this one by Californias Brandee Blank?. Shes covered a lidded glass jar with imitative succulents in polymer. The wide lip of the pot camouflages the top of the jar and makes it a perfect hiding place for whatever small treasures youd like to hide.. ...
Who doesnt need a Stash Jar like this one by Californias Brandee Blank?. Shes covered a lidded glass jar with imitative succulents in polymer. The wide lip of the pot camouflages the top of the jar and makes it a perfect hiding place for whatever small treasures youd like to hide.. ...
afoaf has 3 pf style jars. He uses vermiculate and BRF. He injected spores from 4 holes on top but it is 10th day and jars still have uncolonized parts. I mean in 1 jar myceliums came out just in
Shop Lehmans online for wide mouth canning bands. Comes in a convenient pack of 60! For all wide mouth canning jars, including Ball jars. Made in the USA.
Uncorrected OCR) Abstract of thesis entitled GENE EXPRESSION PROFILE IN HUMAN TROPHOBLAST AND GESTATIONAL TROPHOBLASTIC DISEASE submitted by Feng Hui-Chen for the degree of Doctor of Philosophy at the University of Hong Kong in August 2004 Trophoblast in normal placenta is pseudo-malignant in nature. Neoplastic transformation of trophoblast leads to gestational trophoblastic diseases (GTD). Choriocarcinoma (CCA) and hydatidiform mole (HM) are major types of GTD. Generally GTD shows varying potential for local invasion and metastasis, but responds well to chemotherapy. The major problem in the treatment of GTD is the delay of chemotherapy particularly in highly malignant cases. Identification of predictive molecular markers may improve the early diagnosis for malignant GTD. In this study, both trophoblastic cell lines and clinical tissues were used in the examination of differentially expressed genes using various approaches. Their gene expression profiles were used in the identification of ...
Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy ...
Talk Page}} ==2019== Trophoblastic neoplasms Trophoblastic neoplasms, benign XH8CX2 Hydatidiform mole, NOS XH5325 Partial hydatidiform mole Trophoblastic neoplasms, malignant XH3WM1 Choriocarcinoma combined with other germ cell elements XH0774 Malignant teratoma, trophoblastic XH8PK7 Choriocarcinoma, NOS XH8FW3 Trophoblastic tumour, epithelioid Trophoblastic neoplasms, uncertain whether benign or malignant XH46G2 Invasive hydatidiform mole XH1RM5 Placental site trophoblastic tumour ==2018== ===Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles=== Am J Hum Genet. 2018 Nov 1;103(5):740-751. doi: 10.1016/j.ajhg.2018.10.007. Nguyen NMP1, Ge ZJ1, Reddy R1, Fahiminiya S2, Sauthier P3, Bagga R4, Sahin FI5, Mahadevan S6, Osmond M2, Breguet M3, Rahimi K7, Lapensee L8, Hovanes K9, Srinivasan R10, Van den Veyver IB6, Sahoo T9, Ao A11, Majewski J2, Taketo T12, Slim R13. Author information Abstract Androgenetic complete hydatidiform moles are human pregnancies with no embryos and affect 1 ...
Hydatidiform mole is a common complication of pregnancy with an incidence of 1in 400 pregnancies in India. Although this is a benign condition , it is having the malignant potential too. A repeat curettage after evacuation of hydatidiform mole was generally advocated till 1990s. A thorough curettage at the time of initial evacuation was not performed because of larger size of uterus and risk of perforation. Subsequently a number of studies assessed the usefulness of repeat curettage and found it was unnecessary and not cost effective . However all these studies are retrospective in design and conducted in developed countries where hydatidiform mole is diagnosed earlier because of wider use of ultrasonography. Thus there is a need to perform a well designed prospective study to compare the effectiveness of single evacuation with double evacuation in treatment of hydatidiform mole for prevention of Gestational Trophoblastic Neoplasia.This study compares the effectiveness of single evacuation ...
Mixed germ cell tumors arise from the primordial germ cells located in the developing gonads. The various morphological patterns of germ cell tumors fall under the category of germinomatous or dysgerminomatous. Dysgerminomatous germ cell tumors comprise extraembryonic re yolk sac and placenta, and embryonic differentiation. Subtypes include embryonal carcinoma, yolk sac tumor (extraembryonic), choriocarcinoma (extraembryonic), teratoma (immature and/or mature), polyembryoma and gonadoblastoma. Mixed germ cell tumors include both categories, and may be benign or malignant.. Malignant mixed germ cell tumors comprise ,10% of all malignant ovarian germ cell tumors. The majority of tumors arise in women of reproductive age (,30 years), and clinical presentation varies from nonspecific abdominopelvic pain and fullness to vaginal bleeding. Physical examination of a unilateral or bilateral mass and imaging techniques are important for clinical diagnosis. Tumor markers are also used to help direct the ...
TY - JOUR. T1 - Complete hydatidiform mole and live fetus in a singleton pregnancy with confined placental mosaicism and fetomaternal hemorrhage. T2 - A case report. AU - Baxi, Laxmi V.. AU - Mansukhani, Mahesh. AU - Thaker, Harshwardhan. AU - Parravicini, Elvira. PY - 2014/12/1. Y1 - 2014/12/1. N2 - BACKGROUND: Coexistence of complete mole and a live fetus is uncommon (1:22,000-100,000), more so with euploidy. CASE: We present a case of a molar pregnancy with a euploid fetus who had close fetal evaluation for second trimester bleeding. The patient presented at 29 weeks gestation with decreased fetal movements, a result of fetomaternal hemorrhage. She underwent emergency cesarean section and delivered a live infant. By close followup and a multidisciplinary approach, the appropriate diagnosis and a favorable outcome were achieved. Both mother and the child at 5 years of age are doing well. CONCLUSION: Detailed anatomic and molecular studies demonstrated a complete mole resulting from confined ...
The 1997 International Germ Cell Consensus Classification[9] is a tool for estimating the risk of relapse after treatment of malignant germ cell tumor. A small study of ovarian tumors in girls[10] reports a correlation between cystic and benign tumors and, conversely, solid and malignant tumors. Because the cystic extent of a tumor can be estimated by ultrasound, MRI, or CT scan before surgery, this permits selection of the most appropriate surgical plan to minimize risk of spillage of a malignant tumor. Access to appropriate treatment has a large effect on outcome. A 1993 study of outcomes in Scotland found that for 454 men with non-seminomatous (non-germinomatous) germ cell tumors diagnosed between 1975 and 1989, 5-year survival increased over time and with earlier diagnosis. Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men, even though the unit treated more men with the worst prognosis.[11] Choriocarcinoma ...
Although choriocarcinoma is a highly malignant tumour and a life-threatening disease, it is very sensitive to chemotherapy. ... Women with a malignant form of GTD usually have a very good prognosis.[citation needed] Choriocarcinoma, for example, is an ... The treatment for invasive mole or choriocarcinoma generally is the same. Both are usually treated with chemotherapy. ... Chittenden B, Ahamed E, Maheshwari A (August 2009). "Choriocarcinoma in a postmenopausal woman". Obstet Gynecol. 114 (2 Pt 2): ...
Li, MC; Li, R; Spencer, DB (1956). "Effect of methotrexate upon choriocarcinoma". Proc Soc Exp Biol Med. 93 (2): 361-366. doi: ... Min Chiu Li and his collaborators then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956 ...
choriocarcinoma, ICD-O 9100/3). *guz pęcherzyka żółtkowego (ang. endodermal sinus tumor, ICD-O 9071/3) ...
Li XN, Li YL, Liu GB, Ding YQ (Jan 2005). "Selection of choriocarcinoma-associated genes using bioinformatics". Di 1 Jun Yi Da ...
... of women who developed choriocarcinoma died within a year. Today, with chemotherapy, choriocarcinoma can be cured in almost ... Yarris, Jonathan P; Hunter, Alan J (1 May 2003). "Roy Hertz, M.D. (1909-2002): The cure of choriocarcinoma and its impact on ... Within four months she was "normal without evidence of disease." Li treated two additional patients with choriocarcinoma that ... Li, M. C.; Hertz, R.; Spencer, D. B. (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". ...
Examples include: choriocarcinoma hydatidiform mole Gestational trophoblastic disease. ...
Surgically removed choriocarcinomas from human patients also exhibited a heavily methylated H19 promoter with enhanced H19 ... Choriocarcinomas, in contrast to adrenal carcinomas, have upregulated H19 and downregulated IGF2 expression. The upregulated ... In cell lines derived from human choriocarcinomas, Kopf et al. found that transcription of H19 was under the simultaneous ... to suggest that in cases of choriocarcinomas, the H19 promoter was mutated, allowing it to overcome the transcriptional ...
They are decreased with toxemia, choriocarcinoma, and Placental insufficiency. The placenta and fetus may be regarded as a ...
... migration and invasion of choriocarcinoma". Carcinogenesis. 32 (5): 765-71. doi:10.1093/carcin/bgr033. PMID 21325635. Li Y, ...
Hayakawa K, Takahashi M, Sasaki K, Kawaoi A, Okano T (January 1977). "Primary choriocarcinoma of the lung: case report of two ... Under light microscopy, the giant malignant pleomorphic cells making up a GCCL resemble those found in choriocarcinoma, ... GCCL and primary pulmonary choriocarcinoma can also be differentiated on the basis of ultrastructural features by electron ... a critical distinction to me made because while there is a known standard of care for treating choriocarcinoma, as yet there is ...
Masse, R. J.; Shaw, P. J.; Burgess, M. (2008). "Intracranial choriocarcinoma causing precocious puberty and cured with combined ...
Angiomatous (vascular) type : This is the most common type of choriocarcinoma. It is distinguished by the presence of numerous ...
1957 - The first cancer (choriocarcinoma) was cured with chemotherapy at NCI. 1960 - NCI began funding governmment-supported ...
Choriocarcinoma Herpes Nuclear atypia Nuclear pleomorphism Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and ...
A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. GRCh38: ... but not in choriocarcinoma tumor cells". Journal of Cellular Biochemistry. 36 (2): 121-8. doi:10.1002/jcb.240360203. PMID ... "Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel". Molecular and Cellular ... "Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma". International Journal of Cancer. 41 ...
It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible ... a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15-25. doi:10.1016/ ... "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The ...
In another study, choriocarcinoma cells were grown in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) and results conveyed a ... Results from this study further indicate that activities of this enzyme vary among the different choriocarcinoma cell lines and ... Chou, Janice Y.; Robinson, J. C. (1977-01-01). "Induction of Placental Alkaline Phosphatase in Choriocarcinoma Cells by 5-Bromo ...
... a human placental choriocarcinoma cell line". Journal of Lipid Research. 47 (4): 815-23. doi:10.1194/jlr.M500527-JLR200. PMID ... "Uptake of long chain fatty acids by human placental choriocarcinoma (Be Wo) cells: Role of plasma membrane fatty acid-binding ... "Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (Be Wo) cells". ... "Long-chain Polyunsaturated Fatty Acids Stimulate Cellular Fatty Acid Uptake in Human Placental Choriocarcinoma (Be Wo) Cells". ...
"Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells". J. Pharmacol. Exp. ...
Choriocarcinoma --- Choriocarcinoma is a highly malignant testicular tumor that usually develops in the 2nd and 3rd decades of ... Pure choriocarcinomas are rare and represent only less than 1 percent of all testicular tumors. Choriocarcinomas are composed ... Many choriocarcinomas show extensive hemorrhagic necrosis in the central portion of the tumor; this appears as mixed cystic and ... As microscopic vascular invasion is common in choriocarcinoma, hematogeneous metastasis, especially to the lungs is common. ...
Primary ovarian choriocarcinoma has a poor prognosis and can occur without a pregnancy. They produce high levels of hCG and can ... Choriocarcinoma can occur as a primary ovarian tumor developing from a germ cell, though it is usually a gestational disease ... In addition, the cancer markers used vary with tumor type: choriocarcinomas are monitored with beta-HCG and endodermal sinus ... They can develop further into a variety of other neoplasms, including choriocarcinoma, yolk sac tumor, and teratoma. They occur ...
"Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells". Proc. Natl. Acad. ...
Examples include: Choriocarcinoma Hydatidiform mole Furuya M, Ishida J, Aoki I, Fukamizu A (2008). "Pathophysiology of ...
Ovarian hyperstimulation occurs more often with invasive moles and choriocarcinoma than complete molar pregnancies. A widely ...
Choriocarcinoma tumor cells are TGF-B signaling resistant, as well as lacking Smad3 expression. Studies show that reintroducing ... This suggests that other signaling mechanisms in addition to Smad3 are defective in TGF-B resistant choriocarcinoma. ... Smad3 into choriocarcinoma cells is sufficient to increase TIMP-1 (tissue inhibitor of metalloprotease-1) levels, a mediator of ...
The team is now considering the diagnoses of choriocarcinoma and selective immunoglobulin A deficiency. House disagrees with ...
Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of ... Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of ... Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of ... Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of ...
... and choriocarcinoma, a malignant, rapidly-growing, and metastatic form of cancer. Molar pregnancies can have either partial or ...
They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that ... They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that ...
Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy. ... Choriocarcinoma is a fast-growing cancer that occurs in a womans uterus (womb). The abnormal cells start in the tissue that ... Choriocarcinomas may also occur after an early pregnancy that does not continue (miscarriage). They may also occur after an ...
Choriocarcinoma is a form of cancer that occurs in the female reproductive system. The following Buzzle article elaborates more ... Choriocarcinoma is a type of cancer that develops in a womans uterus (womb). In choriocarcinoma, the placenta that begins to ... Choriocarcinoma is a form of cancer that occurs in the female reproductive system. The following Buzzle article elaborates more ... In some cases, women after healthy delivery may also get choriocarcinoma Symptoms. The patient may not show any symptoms, until ...
Pure choriocarcinoma of the testis is the exception to most of the rules established for testicular seminoma and all other ... Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with ... Testicular Choriocarcinoma Medication. Updated: Apr 04, 2017 * Author: Michael B Williams, MD, MS; Chief Editor: Bradley Fields ... Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. Am J Surg ...
... , Chorioblastoma, Trophoblastic Tumor, Chorioepithelioma, Gestational Trophoblastic Neoplasia, Invasive Mole, ... Choriocarcinomas, [M]Choriocarcinoma, [M]Chorioepithelioma, choriocarcinoma, choriocarcinoma (diagnosis), Choriocarcinoma, no ... Choriocarcinoma (disorder), Choriocarcinoma, NOS, Choriocarcinoma, Chorioepithelioma NOS, Choriocarcinoma (morphologic ... Choriocarcinoma. Choriocarcinoma Aka: Choriocarcinoma, Chorioblastoma, Trophoblastic Tumor, Chorioepithelioma, Gestational ...
Home Education AUAUniversity Education Products & Resources Pathology for Urologists Testis Germ Cell Tumors Choriocarcinoma ... Pure choriocarcinoma is very rare and accounts for ,1% of GCTs.. *Usually is mixed with other GCT components (8% of mixed GCT). ... Classic choriocarcinoma *Mixture of cytotrophoblasts (polygonal cells with clear cytoplasm, bland nucleus and prominent cell ...
Stage I choriocarcinoma Stage 2 choriocarcinoma Stage 3 choriocarcinoma Stage 4 choriocarcinoma "choriocarcinoma" at Dorlands ... Elements of choriocarcinoma in a mixed testicular tumor have no prognostic importance. Choriocarcinomas can also occur in the ... The same is true of choriocarcinoma arising in the ovary. Testicular choriocarcinoma has the worst prognosis of all germ-cell ... Choriocarcinoma of the placenta during pregnancy is preceded by: hydatidiform mole (50% of cases) spontaneous abortion (20% of ...
"Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved 10 August 2012. NIH. "Choriocarcinoma". Retrieved ... Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event during pregnancy in the ... Women with gestational choriocarcinoma may present with abnormal vaginal bleeding, persistent markedly elevated βhCG, or a ... Most patients develop gestational choriocarcinoma shortly after gestational anomalies, but pathology may occur after a long ...
... Parth Rali,1 Jianwu Xie,2 Grishma Rali,3 Mayur Rali,4 Jan Silverman,2 ... M. Schulz, A. Hernandez, and F. Rebora, "Primary chorio-carcinoma of the lung; Case report," Rev Mex Tuberc Enferm Apar Respir ... U. B. M. Kinni, "Primary pulmonary choriocarcinoma: Is it still an enigma," Indian Journal of Chest Diseases and Allied ... X. M. Li, X. Y. Liu, and Z. X. Liu, "Choriocarcinoma with multiple lung, skull and skin metastases in a postmenopausal female: ...
In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on ... and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. ... are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, ... Keywords: choriocarcinoma; epigenetics; histone deacetylase inhibitors choriocarcinoma; epigenetics; histone deacetylase ...
Thirty-one papers originally presented at a conference held in the Philippines, January 1965. Data and discussions on pathology, natural history, diagnosis, and treatment (with emphasis on chemotherapy). The classifications of trophoblastic neoplasms adopted for recommendation to the UICC are presented as Appendix I. Illustrations and bibliographies. ...
Choriocarcinoma is one of the two rarest forms of cancer, but highly treatable. This condition strikes pregnant women, and ... Choriocarcinomas can develop after an abortion, ectopic pregnancy, or genital tumor.. Choriocarcinoma Signs & Symptoms. Some ... Choriocarcinoma Diagnosis & Treatment. One of the biggest risks with this type of cancer is that it can spread quickly to other ... Choriocarcinoma is one of the two rarest forms of cancer, but highly treatable. This condition strikes pregnant women, and ...
Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, ... Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, ... Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute ...
Trophoblastic Neoplasms Choriocarcinoma Device: atomic force microscopy Device: dual polarisation interferometry Phase 4 ... Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma. The safety and scientific validity ... Choriocarcinoma. Trophoblastic Neoplasms. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. ... choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is ...
Choriocarcinoma may occur when an embryo fails to develop, but the placental tissue continues to proliferate. - Stock Image ... in a case of a choriocarcinoma. This is a malignant (cancerous) tumour of trophoblast cells of the placenta. Trophoblast cells ... Keywords: abnormal, cancer, cancerous, carcinoma, cell, choriocarcinoma, disease, female, histology, histopathology, human, ... Caption: Light micrograph of a section through tissue from the uterus, in a case of a choriocarcinoma. This is a malignant ( ...
Preliminary Diagnosis: Choriocarcinoma/Molar Preganancy. I. What imaging technique is first-line for this diagnosis?. *. ... V. Describe the advantages and disadvantages of the alternative techniques for diagnosis of choriocarcinoma/molar pregnancy. * ... Describe the advantages and disadvantages of this technique for diagnosis of choriocarcinoma/molar pregnancy. * Advantages ... Describe the advantages and disadvantages of this technique for diagnosis of choriocarcinoma/molar pregnancy.. Advantages. *. ...
Infantile choriocarcinoma with cutaneous, liver, and lung metastases. By Logan Dance, MD; Apurvi Patel, MD; Mittun Patel, MD; ... Choriocarcinoma is notorious for its life-threating hemorrhagic metastases and famous for being the first solid tumor to be ... Solitary infantile choriocarcinoma of the liver: MRI findings. Pediatr Radiol. 2004 Oct;34(10):820-823. Epub 2004 Jul 28. ... Dance L, Patel A, Patel M, Towbin AJ, Towbin R. Infantile choriocarcinoma with cutaneous, liver, and lung metastases. Appl ...
Primary choriocarcinoma of the ovary arising, presumably, from a germ cell is extremely rare. The patient, a 16 year old girl ... of micturition developed fatal haemoperitoneum due to rupture of a pure primary nongestational ovarian choriocarcinoma. ...
17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like ... we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like ...
A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY ... Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational ... Non-gestational Choriocarcinoma (Choriocarcinoma, Non gestational). Subscribe to New Research on Non-gestational ... 01/01/1986 - "Eight choriocarcinoma cell lines (Two SCH and IMa, were established from non-gestational choriocarcinoma and the ...
OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells Message Subject (Your Name) has forwarded a page to ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ... OCTN2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells. Erik Rytting and Kenneth L. Audus ...
Abstract #4106: Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma. Hui-Juan Zhang, Michelle Siu, ... Methods: Choriocarcinoma cell lines JEG-3 and JAR were treated with PI3K inhibitor LY294002 and possible change in p-PKB (Ser ... However, the role of activated PI3K/PKB in choriocarcinoma is not reported yet. In this study, we investigated the expression ... Immunohistochemical analysis in choriocarcinoma tissue samples confirmed significantly higher p-PKB (Ser473) expression ...
... gestational ovarian choriocarcinoma, pure nongestational ovarian choriocarcinoma, and choriocarcinoma of uncertain etiology. ... Choriocarcinoma of the ovary can be pure choriocarcinoma or, more commonly, mixed with other germ cell components [1]. When ... Not pure choriocarcinoma. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with ... Not pure choriocarcinoma. Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with ...
  • They are associated with an increase risk for the development of neoplasm, specifically choriocarcinoma, a malignant tumor that has a potential to locally invade the uterus and metastasize. (ommegaonline.org)
  • Herein, we report a 47-year-old woman who presented with acute pancreatitis and left hemianopsia and was diagnosed with pancreatic choriocarcinoma with multiple metastases in liver, lung, and brain. (kjpbt.org)
  • Choriocarcinoma is a form of cancer that occurs in the female reproductive system. (buzzle.com)
  • Choriocarcinoma is one of the two rarest forms of cancer, but highly treatable. (knowcancer.com)
  • A choriocarcinoma is type of cancer germ cell containing trophoblast cells. (thefreedictionary.com)
  • Choriocarcinomas are usually referred to an oncologist, a doctor who specializes in cancer treatment. (thefreedictionary.com)
  • Treatment of Choriocarcinoma depends on age of patient, nature, the stage of the disease at the time it is diagnosed and spread of cancer to other parts of the body. (cancerworld.info)
  • Cancer Research UK provides a basic overview of Choriocarcinoma on their website. (cdc.gov)
  • In this study, two choriocarcinoma cell lines, JAR and JEG-3, and the breast cancer cell line, MCF-7, were used to determine whether differences exist in the transcriptional regulation of the TGF-β2 gene. (elsevier.com)
  • choriocarcinoma is a quickly spreading cancer. (mdedge.com)
  • Since choriocarcinomas include syncytiotrophoblasts (beta-HCG producing cells), they cause elevated blood levels of beta-human chorionic gonadotropin. (wikipedia.org)
  • 17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture. (nih.gov)
  • To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. (nih.gov)
  • The effects of activated PI3K/PKB on invasive activity, cell proliferation, apoptosis and cell cycle regulation in choriocarcinoma cells were determined by Matrigel invasion assay, MTT assay, TUNEL and flow cytometry, respectively. (aacrjournals.org)
  • The invasive activity and viability of choriocarcinoma cells were significantly decreased. (aacrjournals.org)
  • Regulation of glycogen synthase activity in choriocarcinoma cells. (eurekamag.com)
  • Choriocarcinomas are cancers that develop from germ cells, cells that ordinarily turn into sperm or eggs. (thefreedictionary.com)
  • Choriocarcinoma JEG-3 cells were transfected with either pEGFP or pEGFP-GRA15 II and cultured for 24 h. (biomedcentral.com)
  • Toxoplasma GRA15 II induced ERS and subsequently caused apoptosis of choriocarcinoma JEG-3 cells. (biomedcentral.com)
  • However, very rarely, choriocarcinoma can develop from germ cells or from dedifferentiation of endometrial carcinoma into choriocarcinoma. (biomedcentral.com)
  • The non-gestational choriocarcinomas are believed to develop from pluripotent germ cells, most commonly arising in the gonads. (biomedcentral.com)
  • We explored the cytotoxic effects of nanobacteria (NB) and nanohydroxyapatites (nHAPs) against human choriocarcinoma cells (JAR) and the mechanisms of action underlying their cytotoxicity. (springeropen.com)
  • Most often this is an invasive mole, but in rare cases it is a choriocarcinoma, a malignant (cancerous) form of GTD. (cancer.org)
  • Y. Ikura, T. Inoue, H. Tsukuda, T. Yamamoto, M. Ueda, and Y. Kobayashi, "Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: Are they independent entities? (hindawi.com)
  • Miliary mottling on lung fields plus hyperthyroidism - miliary tuberculosis or choriocarcinoma? (elsevier.com)
  • Primary choriocarcinoma of the lung is extremely uncommon. (beds.ac.uk)
  • We report a surgically treated case of choriocarcinoma in a 37-year-old woman who came to our attention because of a isolated lung lesion. (beds.ac.uk)
  • Vaginal and uterine biopsies were suggestive of choriocarcinoma. (biomedcentral.com)
  • Choriocarcinoma can invade the uterine tissue and vasculature and spread to distant sites such as lungs , brain , liver , pelvis , vagina , spleen , intestines , and kidney . (wikidoc.org)
  • The ability of retinoic acid (RA) to modulate attachment of JAR choriocarcinoma multicellular spheroids to monolayers of a human uterine epithelial cell line (RL95-2) was examined using a centrifugal force-based adhesion assay. (naver.com)
  • abstract = "A 25-year-old woman, presenting with miliary shadowing on chest radiography, was found to have hyperthyroidism and choriocarcinoma. (elsevier.com)
  • Here are certain symptoms of Choriocarcinoma, with careful examination, management and early diagnosis of the disease outcomes can be improved. (cancerworld.info)
  • Symptoms of Choriocarcinoma commonly depend on the type of the body part affected. (cancerworld.info)
  • Hydatidifporm mole, the leading cause of Choriocarcinoma is the development of grape-like structure that should have normally formed the embryo. (cancerworld.info)
  • CONCLUSION: PET/CT may be useful in the evaluation of occult choriocarcinoma when conventional imaging fails to identify metastatic disease. (uab.edu)
  • Differentiating gestational and nongestational choriocarcinoma can be difficult, as their clinical presentation and pathology can be identical. (oatext.com)
  • U. B. M. Kinni, "Primary pulmonary choriocarcinoma: Is it still an enigma," Indian Journal of Chest Diseases and Allied Sciences , vol. 47, pp. 216-226, 2007. (hindawi.com)
  • Primary pulmonary choriocarcinoma: Case report and review of the literature," Gynecologic and Obstetric Investigation , vol. 74, no. 2, pp. 171-176, 2012. (hindawi.com)
  • Primary extragenital choriocarcinoma most often arises in the retroperitoneum, in the mediastinum, or intracranially. (beds.ac.uk)
  • These findings demonstrate that RA modulates cellular attachment and differentiation in choriocarcinoma spheroids in vitro. (naver.com)