A subfamily of the family POXVIRIDAE, containing eight genera comprising all the vertebrate poxviruses.
Virus diseases caused by the POXVIRIDAE.

Genome of lumpy skin disease virus. (1/11)

Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of LSDV. The 151-kbp LSDV genome consists of a central coding region bounded by identical 2.4 kbp-inverted terminal repeats and contains 156 putative genes. Comparison of LSDV with chordopoxviruses of other genera reveals 146 conserved genes which encode proteins involved in transcription and mRNA biogenesis, nucleotide metabolism, DNA replication, protein processing, virion structure and assembly, and viral virulence and host range. In the central genomic region, LSDV genes share a high degree of colinearity and amino acid identity (average of 65%) with genes of other known mammalian poxviruses, particularly suipoxvirus, yatapoxvirus, and leporipoxviruses. In the terminal regions, colinearity is disrupted and poxvirus homologues are either absent or share a lower percentage of amino acid identity (average of 43%). Most of these differences involve genes and gene families with likely functions involving viral virulence and host range. Although LSDV resembles leporipoxviruses in gene content and organization, it also contains homologues of interleukin-10 (IL-10), IL-1 binding proteins, G protein-coupled CC chemokine receptor, and epidermal growth factor-like protein which are found in other poxvirus genera. These data show that although LSDV is closely related to other members of the Chordopoxvirinae, it contains a unique complement of genes responsible for viral host range and virulence.  (+info)

Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. (2/11)

The Yatapoxvirus genus of poxviruses is comprised of Yaba monkey tumor virus (YMTV), Tanapox virus, and Yaba-like disease virus (YLDV), which all have the ability to infect primates, including humans. Unlike other poxviruses, YMTV induces formation of focalized histiocytomas upon infection. To gain a greater understanding of the Yatapoxvirus genus and the unique tumor formation properties of YMTV, we sequenced the 134,721-bp genome of YMTV. The genome of YMTV encodes at least 140 open reading frames, all of which are also found as orthologs in the closely related YLDV. However, 13 open reading frames found in YLDV are completely absent from YMTV. Common to both YLDV and YMTV are the unusually large noncoding regions between many open reading frames. To determine whether any of these noncoding regions might be functionally significant, we carried out a comparative analysis between the putative noncoding regions of YMTV and similar noncoding regions from other poxviruses. This approach identified three new gene poxvirus families, defined as orthologs of YMTV23.5L, YMTV28.5L, and YMTV120.5L, which are highly conserved in virtually all poxvirus species. Furthermore, the comparative analysis also revealed a 40-bp nucleotide sequence at approximately 14,700 bases from the left terminus that was 100% identical in the comparable intergene site within members of the Yatapoxvirus, Suipoxvirus, and Capripoxvirus genera and 95% conserved in the Leporipoxvirus genus. This conserved sequence was shown to function as a poxvirus late promoter element in transfected and infected cells, but other functions, such as an involvement in viral replication or packaging, cannot be excluded. Finally, we summarize the predicted immunomodulatory protein repertoire in the Yatapoxvirus genus as a whole.  (+info)

A novel poxvirus lethal to red squirrels (Sciurus vulgaris). (3/11)

A parapoxvirus has been implicated in the decline of the red squirrel in the United Kingdom. Virus was isolated from an outbreak of lethal disease in red squirrels in the north-east of England. Experimental infection of captive-bred red squirrels confirmed that this virus was the cause of the severe skin lesions observed. Electron microscopic examination of the virus showed that it had a morphology typical of parapoxviruses whilst preliminary sequence data suggested a genomic G+C composition of approximately 66 %, again similar to that found in other parapoxviruses. However Southern hybridization analysis failed to detect three known parapoxvirus genes, two of which have been found so far only in the genus parapoxvirus. Comparative sequence analysis of two other genes, conserved across the eight recognized chordopoxvirus genera, suggests that the squirrel virus represents a previously unrecognized genus of the chordopoxvirus.  (+info)

A complex of seven vaccinia virus proteins conserved in all chordopoxviruses is required for the association of membranes and viroplasm to form immature virions. (4/11)

Early events in vaccinia virus (VAC) morphogenesis, particularly the formation of viral membranes and their association with viroplasm, are poorly understood. Recently, we showed that repression of A30 or G7 expression results in the accumulation of normal viral membranes that form empty-looking immature virions (IV), which are separated from large masses of electron-dense viroplasm. In addition, A30 and G7 physically and functionally interact with each other and with the F10 protein kinase. To identify other proteins involved in early morphogenesis, proteins from cells that had been infected with vaccinia virus expressing an epitope-tagged copy of F10 were purified by immunoaffinity chromatography and analyzed by gel electrophoresis. In addition to F10, A30, and G7, viral proteins A15, D2, D3, and J1 were identified by mass spectrometry of tryptic peptides. Further evidence for the complex was obtained by immunopurification of proteins associated with epitope-tagged A15, D2, and D3. The previously unstudied A15, like other proteins in the complex, was expressed late in infection, associated with virus cores, and required for the stability and kinase activity of F10. Biochemical and electron microscopic analyses indicated that mutants in which A15 or D2 expression was regulated by the Escherichia coli lac operator system exhibited phenotypes characterized by the presence of large numbers of empty immature virions, similar to the results obtained with inducible A30 and G7 mutants. Empty immature virions were also seen by electron microscopy of cells infected with temperature-sensitive mutants of D2 or D3, though the numbers of membrane forms were reduced perhaps due to additional effects of high temperature.  (+info)

Genome of deerpox virus. (5/11)

Deerpox virus (DPV), an uncharacterized and unclassified member of the Poxviridae, has been isolated from North American free-ranging mule deer (Odocoileus hemionus) exhibiting mucocutaneous disease. Here we report the genomic sequence and comparative analysis of two pathogenic DPV isolates, W-848-83 (W83) and W-1170-84 (W84). The W83 and W84 genomes are 166 and 170 kbp, containing 169 and 170 putative genes, respectively. Nucleotide identity between DPVs is 95% over the central 157 kbp. W83 and W84 share similar gene orders and code for similar replicative, structural, virulence, and host range functions. DPV open reading frames (ORFs) with putative virulence and host range functions include those similar to cytokine receptors (R), including gamma interferon receptor (IFN-gammaR), interleukin 1 receptor (IL-1R), and type 8 CC-chemokine receptors; cytokine binding proteins (BP), including IL-18BP, IFN-alpha/betaBP, and tumor necrosis factor binding protein (TNFBP); serpins; and homologues of vaccinia virus (VACV) E3L, K3L, and A52R proteins. DPVs also encode distinct forms of major histocompatibility complex class I, C-type lectin-like protein, and transforming growth factor beta1 (TGF-beta1), a protein not previously described in a mammalian chordopoxvirus. Notably, DPV encodes homologues of cellular endothelin 2 and IL-1R antagonist, novel poxviral genes also likely involved in the manipulation of host responses. W83 and W84 differ from each other by the presence or absence of five ORFs. Specifically, homologues of a CD30 TNFR family protein, swinepox virus SPV019, and VACV E11L core protein are absent in W83, and homologues of TGF-beta1 and lumpy skin disease virus LSDV023 are absent in W84. Phylogenetic analysis indicates that DPVs are genetically distinct from viruses of other characterized poxviral genera and that they likely comprise a new genus within the subfamily Chordopoxvirinae.  (+info)

Genome of crocodilepox virus. (6/11)

Here, we present the genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV). The genome is 190,054 bp (62% G+C) and predicted to contain 173 genes encoding proteins of 53 to 1,941 amino acids. The central genomic region contains genes conserved and generally colinear with those of other chordopoxviruses (ChPVs). CRV is distinct, as the terminal 33-kbp (left) and 13-kbp (right) genomic regions are largely CRV specific, containing 48 unique genes which lack similarity to other poxvirus genes. Notably, CRV also contains 14 unique genes which disrupt ChPV gene colinearity within the central genomic region, including 7 genes encoding GyrB-like ATPase domains similar to those in cellular type IIA DNA topoisomerases, suggestive of novel ATP-dependent functions. The presence of 10 CRV proteins with similarity to components of cellular multisubunit E3 ubiquitin-protein ligase complexes, including 9 proteins containing F-box motifs and F-box-associated regions and a homologue of cellular anaphase-promoting complex subunit 11 (Apc11), suggests that modification of host ubiquitination pathways may be significant for CRV-host cell interaction. CRV encodes a novel complement of proteins potentially involved in DNA replication, including a NAD(+)-dependent DNA ligase and a protein with similarity to both vaccinia virus F16L and prokaryotic serine site-specific resolvase-invertases. CRV lacks genes encoding proteins for nucleotide metabolism. CRV shares notable genomic similarities with molluscum contagiosum virus, including genes found only in these two viruses. Phylogenetic analysis indicates that CRV is quite distinct from other ChPVs, representing a new genus within the subfamily Chordopoxvirinae, and it lacks recognizable homologues of most ChPV genes involved in virulence and host range, including those involving interferon response, intracellular signaling, and host immune response modulation. These data reveal the unique nature of CRV and suggest mechanisms of virus-reptile host interaction.  (+info)

Genomic characterization of a novel poxvirus contributing to the decline of the red squirrel (Sciurus vulgaris) in the UK. (7/11)

The genome of a virulent squirrelpox virus (SQPV) isolate was characterized in order to determine its relationship with other poxviruses. Restriction enzyme analysis suggested a genome length of approximately 158 kb, whilst sequence analysis of the two ends of the genome indicated a G + C composition of approximately 66 %. Two contiguous stretches of 23 and 37 kb at the left-hand and right-hand ends of the genome, respectively, were sequenced allowing the identification of at least 59 genes contained therein. The partial sequence of a further 15 genes was determined by spot sequencing of restriction fragments located across the genome. Phylogenetic analysis of 15 genes conserved in all the recognized genera of the subfamily Chordopoxvirinae confirmed that the SQPV does not group within the family Parapoxvirinae, but instead partitions on its own in a separate clade of the poxviruses. Analysis of serum from British woodland rodents failed to find any evidence of SQPV infection in wood mice or bank voles, but for the first time serum samples from grey squirrels in the USA were found to contain antibody against SQPV.  (+info)

Characterization of DNA-binding activity of Z alpha domains from poxviruses and the importance of the beta-wing regions in converting B-DNA to Z-DNA. (8/11)

The E3L gene is essential for pathogenesis in vaccinia virus. The E3L gene product consists of an N-terminal Z alpha domain and a C-terminal double-stranded RNA (dsRNA) binding domain; the left-handed Z-DNA-binding activity of the Z alpha domain of E3L is required for viral pathogenicity in mice. E3L is highly conserved among poxviruses, including the smallpox virus, and it is likely that the orthologous Z alpha domains play similar roles. To better understand the biological function of E3L proteins, we have investigated the Z-DNA-binding behavior of five representative Z alpha domains from poxviruses. Using surface plasmon resonance (SPR), we have demonstrated that these viral Z alpha domains bind Z-DNA tightly. Ability of Z alpha(E3L) converting B-DNA to Z-DNA was measured by circular dichroism (CD). The extents to which these Z alphas can stabilize Z-DNA vary considerably. Mutational studies demonstrate that residues in the loop of the beta-wing play an important role in this stabilization. Notably the Z alpha domain of vaccinia E3L acquires ability to convert B-DNA to Z-DNA by mutating amino acid residues in this region. Differences in the host cells of the various poxviruses may require different abilities to stabilize Z-DNA; this may be reflected in the observed differences in behavior in these Zalpha proteins.  (+info)

There is no specific treatment for poxviridae infections, but antiviral medications may be used in some cases. Vaccination against smallpox, which is caused by the variola virus, a member of the poxviridae family, has been widely used to prevent this disease and has been declared eradicated by the World Health Organization (WHO). However, other poxviridae infections remain a significant public health concern, particularly in areas where there is limited access to medical care.

Prevention of poxviridae infections involves avoiding contact with infected animals or people, wearing protective clothing and equipment, and practicing good hygiene. In addition, vaccination against specific poxviridae infections, such as monkeypox and cowpox, may be recommended for certain individuals who are at high risk of infection.

Overall, while the eradication of smallpox is a significant achievement, there remains much work to be done to prevent and control poxviridae infections, particularly in areas with limited access to medical care.

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Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > ...
Myxoma virus is in the genus Leporipoxvirus (family Poxviridae; subfamily Chordopoxvirinae). Like other poxviruses, myxoma ...
Parapoxvirus is classified into the subfamily of Chordopoxvirinae. Generally, viruses within the Poxviridae family have brick ...
There are ten recognised genera in the Chordopoxvirinae and three in the Entomopoxvirinae. The following subfamilies and genera ... appears to be the earliest branch in the Chordopoxvirinae. A new systematic has been proposed recently after findings of a new ... the Deepest Representative of the Chordopoxvirinae". J Virol. 89 (18): 9348-9867. doi:10.1128/JVI.01174-15. PMC 4542343. PMID ... The species in the subfamily Chordopoxvirinae infect vertebrates and those in the subfamily Entomopoxvirinae infect insects. ...
It is an orthopoxvirus in the family Poxviridae and subfamily Chordopoxvirinae. DNA sequences encoding the HA's of RCN and VV ( ... is a double-stranded DNA virus and a member of the orthopoxviruses in the family Poxviridae and subfamily Chordopoxvirinae ... Suipoxvirus and Yatapoxvirus Vertebrates are the natural host of Chordopoxvirinae subfamily viruses. More specifically, ...
MCV is a member of the subfamily Chordopoxvirinae of family Poxviridae. Other commonly known viruses that reside in the ... subfamily Chordopoxvirinae are variola virus (cause of smallpox) and monkeypox virus. The poxvirus family uniquely contains ...
... is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and ...
... is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Swine serve as natural hosts. There ...
... is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Lagomorphs and squirrels ...
... is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Like all members of the family ...
... is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Crocodiles serve as ...
... is a genus of viruses in the subfamily Chordopoxvirinae and the family Poxviridae. Capripoxviruses are among the ...
... is a genus of viruses in the family Poxviridae in the subfamily Chordopoxvirinae. Birds serve as natural hosts. ... Chordopoxvirinae, Bird diseases, Animal viral diseases, Virus genera). ...
... is a genus of viruses in the family Poxviridae in the subfamily Chordopoxvirinae. Deer serve as natural hosts. ...
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... was caused by infection with variola virus, which belongs to the family Poxviridae, subfamily Chordopoxvirinae, and ... Chordopoxvirinae, Eradicated diseases, Virus-related cutaneous conditions, Wikipedia medicine articles ready to translate). ...
... is a disease of camels caused by the camelpox virus (CMPV) of the family Poxviridae, subfamily Chordopoxvirinae, and ... Chordopoxvirinae, Camelid diseases, Animal viral diseases, Camels). ...
List of other related viruses which may be members of the subfamily Chordopoxvirinae but have not been approved as species ... Chordopoxvirinae, Animal viral diseases, Virus-related cutaneous conditions, Species described in 1972, Infraspecific virus ...
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Chordopoxvirinae, Animal viral diseases, Virus-related cutaneous conditions). ...
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... chordopoxvirinae MeSH B04.280.650.160.100 - avipoxvirus MeSH B04.280.650.160.100.149 - canarypox virus MeSH B04.280.650.160. ... chordopoxvirinae MeSH B04.909.204.783.160.100 - avipoxvirus MeSH B04.909.204.783.160.100.149 - canarypox virus MeSH B04.909. ...
Chordopoxvirinae, Animal viral diseases). ...
Chordopoxvirinae, Bird diseases, Animal viral diseases). ...
Chordopoxvirinae, Animal viral diseases, Virus-related cutaneous conditions, All stub articles, Virus stubs, Veterinary ...
Chordopoxvirinae, Virus-related cutaneous conditions, Genetic engineering). ...
Chordopoxvirinae, Monkeypox). ...
Home , Archives , Vol 63, No 2 (2018) , POXVIRUS DISEASE OF SQUIRRELS (POXVIRIDAE, CHORDOPOXVIRINAE, SQPV - SQUIRREL POXVIRUS) ... POXVIRUS DISEASE OF SQUIRRELS (POXVIRIDAE, CHORDOPOXVIRINAE, SQPV - SQUIRREL POXVIRUS) - PDF (Russian). Download this PDF file ... "ОСПА БЕЛОК (POXVIRIDAE, CHORDOPOXVIRINAE, SQPV - SQUIRREL POXVIRUS) ...
Mercer, A., & Fleming, S. (2012). Parapoxvirus: Poxviridae, Chordopoxvirinae. In C. Tidona & G. Darai (Eds.), The Springer ...
... and Chordopoxvirinae, whose members are found in mammals, birds, reptiles and fish. Poxviruses are important pathogens in ...
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Categories: Chordopoxvirinae Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
7. [Determination of the optimal immunizing dose of heterologous goat pox virus vaccine (Poxviridae: Chordopoxvirinae: ...
Poxviridae consists of 2 subfamilies: Chordopoxvirinae, which infects vertebrates, and Entomopoxvirinae, which infects insects ...
Avipoxviruses are large, enveloped DNA viruses that belong to the genus Avipoxvirus in the Chordopoxvirinae subfamily of the ...
The family Poxviridae is subdivided (based on their animal hosts) into two subfamilies, namely Chordopoxvirinae and ...
Chordopoxvirinae Preferred Term Term UI T054308. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Chordopoxvirinae Preferred Concept UI. M0027353. Registry Number. txid10241. Scope Note. A subfamily of the family POXVIRIDAE, ... Chordopoxvirinae. Tree Number(s). B04.280.650.160. Unique ID. D018147. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Variola virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus Orthopoxvirus. It is a single, linear, ...
Chordopoxvirinae B04.280.650.160.100 Avipoxvirus B04.280.650.160.100.149 Canarypox virus B04.280.650.160.100.300 Fowlpox virus ...
Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. Gjessing, Mona C; Yutin, Natalya; Tengs, Torstein; ... Erratum for Gjessing et al., Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. Gjessing, Mona C; Yutin ...
... subfamily Chordopoxvirinae), that occurs mostly in the rain forests of central and western Africa. People living in or near the ...
Subfamily: Chordopoxvirinae. Genus: Suipoxvirus. Distinguishing features. The Suipoxvirus genus includes one virus species, ...
Chordopoxvirinae - Preferred Concept UI. M0027353. Scope note. A subfamily of the family POXVIRIDAE, containing eight genera ... Chordopoxvirinae. Scope note:. Subfamilia de la familia POXVIRIDAE; contiene ocho géneros que comprenden todos los poxvirus de ...
Chordopoxvirinae B4.909.204.783.160 Choriocarcinoma C4.557.465.955.416.202 C4.850.908.208 C4.850.908.416.186 C13.703.720.949. ...
Chordopoxvirinae Preferred Term Term UI T054308. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Chordopoxvirinae Preferred Concept UI. M0027353. Registry Number. txid10241. Scope Note. A subfamily of the family POXVIRIDAE, ... Chordopoxvirinae. Tree Number(s). B04.280.650.160. Unique ID. D018147. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Phylogenetic analyses indicated the virus differed 35% from its closest relatives, the Chordopoxvirinae. Future research is ...
Characteristics: Virus belongs to household Poxviridae, sub-family Chordopoxvirinae and genus OrthopoxvirusFootnote 1Footnote ...
Chordopoxvirinae and Entomopoxvirinae. The subfamily Chordopoxvirinae contains viruses that infect vertebrate hosts and include ...
... subfamily CHORDOPOXVIRINAE. Canarypox virus vectors are used in vaccine and immunotherapy research. AN - infection: coord IM ...
Chordopoxvirinae B4.909.204.783.160 Choriocarcinoma C4.557.465.955.416.202 C4.850.908.208 C4.850.908.416.186 C13.703.720.949. ...
Chordopoxvirinae B4.909.204.783.160 Choriocarcinoma C4.557.465.955.416.202 C4.850.908.208 C4.850.908.416.186 C13.703.720.949. ...
Chordopoxvirinae B4.909.204.783.160 Choriocarcinoma C4.557.465.955.416.202 C4.850.908.208 C4.850.908.416.186 C13.703.720.949. ...
... subfamily Chordopoxvirinae. Despite being discovered in captive monkeys in 1958 and humans from the Democratic Republic of the ...
... virus (MPV) belong to genus orthopoxvirus of Poxviridae family (subfamily- Chordopoxvirinae).6 Other members of ...
  • Chordopoxvirinae is a diverse subfamily of viruses within Poxviridae . (cdc.gov)
  • Poxviridae consists of 2 subfamilies: Chordopoxvirinae, which infects vertebrates, and Entomopoxvirinae, which infects insects. (medscape.com)
  • Characteristics: Virus belongs to household Poxviridae, sub-family Chordopoxvirinae and genus OrthopoxvirusFootnote 1Footnote 4Footnote 5. (aahanagroups.com)
  • The family Poxviridae, based on whether they infect insect or vertebrate hosts, has been classified into two subfamilies, Chordopoxvirinae and Entomopoxvirinae. (brainkart.com)
  • The subfamily Chordopoxvirinae contains viruses that infect vertebrate hosts and include eight genera, of which at least four genera cause diseases in humans. (brainkart.com)
  • Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae. (bvsalud.org)