A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
Spinal neoplasms are abnormal growths or tumors that develop within the spinal column, which can be benign or malignant, and originate from cells within the spinal structure or spread to the spine from other parts of the body (metastatic).
The last bone in the VERTEBRAL COLUMN in tailless primates considered to be a vestigial tail-bone consisting of three to five fused VERTEBRAE.
The body region between (and flanking) the SACRUM and COCCYX.
The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Neoplasms of the bony part of the skull.
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.
A surgical specialty concerned with the treatment of diseases and disorders of the brain, spinal cord, and peripheral and sympathetic nervous system.
Relations of an individual, association, organization, hospital, or corporation with the publics which it must take into consideration in carrying out its functions. Publics may include consumers, patients, pressure groups, departments, etc.
Self-administered health questionnaire developed to obtain details of the medical history as an adjunct to the medical interview. It consists of 195 questions divided into eighteen sections; the first twelve deal with somatic complaints and the last six with mood and feeling patterns. The Index is used also as a personality inventory or in epidemiologic studies.
The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.
The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.
**I'm really sorry, but I can't fulfill your request.**
The deliberate attempt to influence attitudes and beliefs for furthering one's cause or damaging an opponent's cause.

Recurrence of clival chordoma along the surgical pathway. (1/174)

Chordomas are locally aggressive malignant tumors of notochordal origin whose metastatic potential is increasingly recognized. Surgical pathway recurrence has been noted only rarely in the literature. We present three patients with clival chordomas whose sole or initial recurrence was along the pathway of prior surgical access. A characteristic mass found along the pathway of prior surgical access for resection of a chordoma should suggest recurrent chordoma.  (+info)

Sacral chordoma--a case report. (2/174)

Chordoma, a rare malignant tumour of early adulthood, rarely presents in children. We report such a case of rare malignant tumour which was diagnosed in the first decade of life.  (+info)

Isolated cardiac metastasis from sacral chordoma. (3/174)

A 64-year-old woman presented with right heart failure caused by a cardiac tumor centered in the free wall of the right ventricle, accompanied by pericardial effusion. A match between the biopsy specimen and tissue removed 4 years earlier resulted in the diagnosis of a cardiac metastasis from a chordoma. Immunohistochemical staining was also useful in establishing the diagnosis. To alleviate the right ventricular outflow obstruction, a palliative operation was planned, resecting the tumor and performing a right ventriculoplasty, which was cancelled due to the extent of infiltration of the tumor, and instead a right atrium to pulmonary artery shunt was attempted using a vascular prosthesis, only to fail due to an inability to maintain blood flow through the prosthesis. Presently there are no definitive treatment options available, and some palliative chemotherapy is being performed. Single cardiac metastases from a chordoma are extremely rare.  (+info)

Chordoid glioma: a neoplasm unique to the hypothalamus and anterior third ventricle. (4/174)

BACKGROUND AND PURPOSE: Chordoid glioma is a new clinicopathologic entity that occurs in the region of the hypothalamus/anterior third ventricle. The aims of this study were to describe the characteristic radiographic features of chordoid glioma, identify specific imaging features that may enable differentiation of chordoid glioma from other suprasellar tumors, and increase neuroradiologists' awareness of this newly described tumor, facilitating prospective diagnosis. METHODS: CT scans and/or MR images of six patients with chordoid glioma were reviewed retrospectively to determine whether any characteristic radiographic features would emerge. Reports of the clinical presentation, pathologic findings, and radiographic findings of another six patients were reviewed and included, for a total patient population of 12 (mean age +/- SD, 46 +/- 13 years). RESULTS: Imaging features were strikingly similar for all tumors. In each case, the mass was ovoid, was well circumscribed, was located in the region of the hypothalamus/anterior third ventricle, and enhanced uniformly and intensely. Tumors were hyperdense to gray matter on CT scans and were isointense on T1-weighted MR images and slightly hyperintense on long-TR MR images. In two patients, vasogenic edema extended into the optic tracts, and in three, there was hydrocephalus. CONCLUSION: Chordoid glioma is a recently described unique histopathologic entity that has been added to the World Health Organization glioma classification scheme and must be included in the differential diagnosis of a suprasellar mass. Distinctive imaging features are its location, ovoid shape, hyperdensity on CT scans, and uniform intense contrast enhancement.  (+info)

Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development. (5/174)

Chordoma is the fourth most common malignant primary neoplasm of the skeleton and almost the only one showing a real epithelial phenotype. Besides classic chordoma, so-called chondroid chordoma was described as a specific entity showing cartilage-like tissue within chordomatoid structures. However, since its first description, strongly conflicting results have been reported about the existence of chondroid chordoma and several studies suggested chondroid chordomas being in fact low-grade conventional chondrosarcomas. In the present study, we used cytoprotein expression profiling and molecular in situ localization techniques of marker gene products indicative of developmental phenotypes of chondrocytes to elucidate origin and biology of chondroid chordoma. We were able to demonstrate the chondrogenic potential of chordomas irrespectively of the appearance of overt cartilage formation by identifying the multifocal expression of type II collagen, the main marker of chondrocytic differentiation. Additionally, the cartilage-typical large aggregating proteoglycan aggrecan was present throughout all chordomas and, thus, a very characteristic gene product and marker of these neoplasms. Biochemical matrix composition and cell differentiation pattern analysis showed a high resemblance of classic chordomas and in chordoid areas of chondroid chordomas to the fetal chorda dorsalis, whereas chondroid areas of chondroid chordomas showed features similar to adult nucleus pulposus. This demonstrates on the cell function level the chondrocytic differentiation potential of neoplastic chordoid cells as a characteristic facet of chordomas, mimicking fetal vertebral development, ie, the transition of the chorda dorsalis to the nucleus pulposus. Our study firmly establishes a focal real chondrocytic phenotype of neoplastic cells in chordomas. Chondroid chordoma is neither a low-grade chondrosarcoma nor a misnomer as discussed previously.  (+info)

Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (6/174)

Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. We performed a genomewide analysis for linkage in a family with 10 individuals affected by chordoma. The maximum two-point LOD score based on only the affected individuals was 2.21, at recombination fraction 0, at marker D7S2195 on chromosome 7q. Combined analysis of additional members of this family (11 affected individuals) and of two unrelated families (one with 2 affected individuals and the other with 3 affected individuals), with 20 markers on 7q, showed a maximum two-point LOD score of 4.05 at marker D7S500. Multipoint analysis based on only the affected individuals gave a maximum LOD score of 4.78, with an approximate 2-LOD support interval from marker D7S512 to marker D7S684. Haplotype analysis of the three families showed a minimal disease-gene region from D7S512 to D7S684, a distance of 11.1 cM and approximately 7.1 Mb. No loss of heterozygosity was found at markers D7S1804, D7S1824, and D7S2195 in four tumor samples from affected family members. These results map a locus for familial chordoma to 7q33. Further analysis of this region, to identify this gene, is ongoing.  (+info)

Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. (7/174)

BACKGROUND AND PURPOSE: This study was undertaken to analyze enhancement patterns of the dura around sellar tumors and to compare the results with tumor invasion or compression of the cavernous sinuses. Postoperative enhancement patterns on MR images were compared with preoperative findings. METHODS: Contrast-enhanced coronal and sagittal MR images were examined prospectively in 96 patients with sellar tumors (65 macroadenomas, 15 microadenomas, 14 Rathke cleft cysts, and two chordomas at the sella). All patients underwent surgical treatment, and pre- and postsurgical features on MR images were compared. RESULTS: Presurgical MR images showed dural enhancement in 36.5% of the patients: asymmetric tentorial enhancement in 24 patients, symmetric tentorial enhancement in seven, and sphenoidal ridge or clivus enhancement in four. Asymmetric tentorial enhancement disappeared after surgical decompression in seven patients. For evaluation of cavernous sinus invasion ipsilateral to the enhancement, sensitivity and specificity of the asymmetric tentorial enhancement sign were 81.3% and 86.3%, respectively. Sensitivity and specificity of the sign were 42.9% and 93.6% for cavernous sinus involvement, including compression and invasion. CONCLUSION: Asymmetric tentorial enhancement is a useful sign in the diagnosis of invasion or severe compression of the cavernous sinus by sellar tumor. The sign may represent venous congestion or collateral flow in the tentorium due to obstructed flow in the medial portion of the cavernous sinus.  (+info)

Vertebral reconstruction with cortical allograft: long-term evaluation. (8/174)

Reconstruction of large anterior vertebral column defects is indicated in a number of pathological conditions including tumor, infection, trauma and post-traumatic deformity. Several substitutes and techniques are available for the functional restoration of the vertebral column. Vascularized bone transfers, autografts, allografts or xenografts have been used, as well as metal or ceramic implants. All of these bear potential advantages and drawbacks in terms of associated morbidity of graft harvesting, disease transmission, mechanical failure, implant incorporation and overall long-term clinical outcome. In the present paper we report our experience with the use of freeze-dried, gamma-irradiated, cortical allograft for the reconstruction of large, anterior segmental defects of the spine, involving at least one vertebral body with its two adjacent discs. Cortical allografts were used in 67 cases operated for a variety of conditions. No case of disease transmission, infection or long-term mechanical graft failure occurred in our entire series, with a mean follow-up of 31 months. Fusion and mechanical stability was reliably obtained. Specific advantages include the absence of donor site morbidity, the possibilities for exact trimming to the size of the defect, superior mechanical strength as compared to available autograft, and reliable fusion with the host bone with partial bone remodeling, preventing fatigue failure. We conclude that freeze-dried, irradiated cortical allografts are safe and effective for anterior reconstruction of the spine.  (+info)

A chordoma is a rare, slow-growing tumor that typically develops in the bones of the spine or skull. These tumors originate from remnants of the notochord, a structure that forms during embryonic development and eventually becomes part of the spinal cord. Chordomas are usually low-grade malignancies but can be aggressive and locally invasive, potentially causing pain, neurological symptoms, or structural damage to the spine or skull. Treatment typically involves surgical resection, often combined with radiation therapy.

Skull base neoplasms refer to abnormal growths or tumors located in the skull base, which is the region where the skull meets the spine and where the brain connects with the blood vessels and nerves that supply the head and neck. These neoplasms can be benign (non-cancerous) or malignant (cancerous), and they can arise from various types of cells in this area, including bone, nerve, glandular, and vascular tissue.

Skull base neoplasms can cause a range of symptoms depending on their size, location, and growth rate. Some common symptoms include headaches, vision changes, hearing loss, facial numbness or weakness, difficulty swallowing, and balance problems. Treatment options for skull base neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The specific treatment plan will depend on the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history.

The sacrum is a triangular-shaped bone in the lower portion of the human vertebral column, located between the lumbar spine and the coccyx (tailbone). It forms through the fusion of several vertebrae during fetal development. The sacrum's base articulates with the fifth lumbar vertebra, while its apex connects with the coccyx.

The sacrum plays an essential role in supporting the spine and transmitting weight from the upper body to the pelvis and lower limbs. It also serves as an attachment site for various muscles and ligaments. The sacral region is often a focus in medical and chiropractic treatments due to its importance in spinal stability, posture, and overall health.

Spinal neoplasms refer to abnormal growths or tumors found within the spinal column, which can be benign (non-cancerous) or malignant (cancerous). These tumors can originate in the spine itself, called primary spinal neoplasms, or they can spread to the spine from other parts of the body, known as secondary or metastatic spinal neoplasms. Spinal neoplasms can cause various symptoms, such as back pain, neurological deficits, and even paralysis, depending on their location and size. Early diagnosis and treatment are crucial to prevent or minimize long-term complications and improve the patient's prognosis.

The coccyx, also known as the tailbone, is the small triangular bone at the bottom of the spine in humans and other primates. It is formed by the fusion of several small vertebrae and serves to attach muscles and ligaments in the pelvic region. The coccyx can be a source of pain and discomfort if it is injured or becomes inflamed.

The sacrococcygeal region is the lower part of the back where the spine ends, specifically referring to the area where the sacrum (a triangular bone at the base of the spine formed by the fusion of several vertebrae) meets the coccyx (also known as the tailbone). This region is located at the very bottom of the spine and is susceptible to injury or trauma due to its position and role in supporting the body's weight. It is also a common site for birth defects, particularly in newborns.

The posterior cranial fossa is a term used in anatomy to refer to the portion of the skull that forms the lower, back part of the cranial cavity. It is located between the occipital bone and the temporal bones, and it contains several important structures including the cerebellum, pons, medulla oblongata, and the lower cranial nerves (IX-XII). The posterior fossa also contains the foramen magnum, which is a large opening through which the spinal cord connects to the brainstem. This region of the skull is protected by the occipital bone, which forms the base of the skull and provides attachment for several neck muscles.

Chondrosarcoma is a type of cancer that develops in the cartilaginous tissue, which is the flexible and smooth connective tissue found in various parts of the body such as the bones, ribs, and nose. It is characterized by the production of malignant cartilage cells that can invade surrounding tissues and spread to other parts of the body (metastasis).

Chondrosarcomas are typically slow-growing tumors but can be aggressive in some cases. They usually occur in adults over the age of 40, and men are more commonly affected than women. The most common sites for chondrosarcoma development include the bones of the pelvis, legs, and arms.

Treatment for chondrosarcoma typically involves surgical removal of the tumor, along with radiation therapy or chemotherapy in some cases. The prognosis for chondrosarcoma depends on several factors, including the size and location of the tumor, the grade of malignancy, and whether it has spread to other parts of the body.

Skull neoplasms refer to abnormal growths or tumors that develop within the skull. These growths can be benign (non-cancerous) or malignant (cancerous). They can originate from various types of cells, such as bone cells, nerve cells, or soft tissues. Skull neoplasms can cause various symptoms depending on their size and location, including headaches, seizures, vision problems, hearing loss, and neurological deficits. Treatment options include surgery, radiation therapy, and chemotherapy. It is important to note that a neoplasm in the skull can also refer to metastatic cancer, which has spread from another part of the body to the skull.

A chondroma is a benign, slow-growing tumor that develops in the cartilage. Cartilage is a type of connective tissue found in various parts of the body, including the joints, ribcage, and nose. Chondromas are most commonly found in the hands and feet.

Chondromas are typically small, measuring less than 2 centimeters in diameter, and they usually do not cause any symptoms. However, if a chondroma grows large enough to press on nearby nerves or blood vessels, it may cause pain, numbness, or weakness in the affected area.

Chondromas are usually diagnosed through imaging tests such as X-rays, CT scans, or MRI scans. If a chondroma is suspected based on these tests, a biopsy may be performed to confirm the diagnosis and rule out other types of tumors.

Treatment for chondromas typically involves surgical removal of the tumor. In most cases, this can be done using minimally invasive techniques that allow for quicker recovery times. After surgery, patients will need to follow up with their healthcare provider to ensure that the tumor has been completely removed and to monitor for any signs of recurrence.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

The notochord is a flexible, rod-shaped structure that is present in the embryos of chordates, including humans. It is composed of cells called chordocytes and is surrounded by a sheath. The notochord runs along the length of the body, providing support and flexibility. In human embryos, the notochord eventually becomes part of the discs between the vertebrae in the spine. An abnormal or absent notochord can lead to developmental problems with the spine and nervous system.

Neurosurgery, also known as neurological surgery, is a medical specialty that involves the diagnosis, surgical treatment, and rehabilitation of disorders of the nervous system. This includes the brain, spinal cord, peripheral nerves, and extra-cranial cerebrovascular system. Neurosurgeons use both traditional open and minimally invasive techniques to treat various conditions such as tumors, trauma, vascular disorders, infections, stroke, epilepsy, pain, and congenital anomalies. They work closely with other healthcare professionals including neurologists, radiologists, oncologists, and critical care specialists to provide comprehensive patient care.

I apologize, but "Public Relations" is not a term that has a medical definition. Public relations is a field of study and practice that focuses on managing the spread of information between an individual or an organization and the public. It involves building and maintaining a positive reputation, handling crises, and fostering relationships with various stakeholders.

If you have any questions related to healthcare or medicine, I'd be happy to help. Just let me know!

The Cornell Medical Index is a standardized medical history questionnaire that was widely used in healthcare settings to gather comprehensive information about a patient's health status, medical history, and lifestyle. The questionnaire consists of over 180 questions covering various aspects of a person's health, including symptoms, diagnoses, treatments, hospitalizations, surgeries, allergies, family medical history, social habits, and psychological factors.

The Cornell Medical Index was first developed in the 1940s by Dr. John P. Peters and his colleagues at Cornell University Medical College (now Weill Cornell Medicine) as a tool to help physicians gather and organize patient information more efficiently. The questionnaire was designed to be completed by the patient or their family members, and it typically took about 20-30 minutes to complete.

The use of the Cornell Medical Index has declined in recent years due to the advent of electronic health records and other digital tools for collecting patient information. However, it remains a valuable resource for healthcare providers seeking to obtain a comprehensive understanding of their patients' medical histories and health status.

A Tobacco Industry is a commercial sector involved in the cultivation, production, manufacturing, marketing, and distribution of tobacco and tobacco-related products. This can include growers who produce tobacco leaves, manufacturers who process the leaves into various forms (such as cigarettes, chewing tobacco, or snuff), and companies that market and distribute these products to consumers. It is important to note that the tobacco industry has been associated with significant health risks, as the use of tobacco products can lead to a range of serious health problems, including cancer, heart disease, and lung disease.

The term "appointments and schedules" is commonly used in the medical field to refer to the planned or designated times for patients to see healthcare professionals for medical services. Here are the definitions of each term:

1. Appointment: A prearranged meeting between a patient and a healthcare professional at a specific time and date. An appointment is typically made in advance, either by the patient or the healthcare professional's office staff, to ensure that both parties are available to meet at the designated time.
2. Schedule: A list of appointments or activities that are planned for a specific period, such as a day, week, or month. In a medical setting, a schedule may include appointments for patients to see their healthcare professionals, as well as times for procedures, tests, and other medical services.

Together, appointments and schedules help ensure that healthcare professionals can provide timely and efficient care to their patients. They also allow patients to plan their visits to the doctor's office or hospital around their own busy schedules.

I'm sorry for any confusion, but "New York" is not a medical term or concept. New York refers to a state in the United States, as well as its largest city. If you have any questions about medical terminology or concepts, I would be happy to help with those!

I am not a medical professional, but I can tell you that the term "propaganda" is not typically used as a medical definition. Propaganda is a form of communication that is aimed at influencing the attitudes, beliefs, and behaviors of a population. It often presents a biased or misleading view of information in order to further an agenda or promote a particular point of view.

However, in the context of public health and medical communications, propaganda can refer to the dissemination of misinformation or manipulated information about health-related topics with the intention of shaping public opinion or behavior. This can be particularly problematic in the field of medicine, where accurate and unbiased information is critical for making informed decisions about healthcare and treatment options.

It's important to note that while propaganda can be used to promote positive messages and behaviors, such as encouraging people to get vaccinated or practice safe sex, it can also be used to spread misinformation and fear, leading to harmful consequences for individuals and communities.

In layman's terms, chordoma is a type of spinal cancer. Chordomas can arise from bone in the skull base and anywhere along the ... Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. In 2015 the first consensus guidelines for the ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ... Expert Recommendations for the Diagnosis and Treatment of Chordoma is a handbook produced by the Chordoma Foundation, which ...
A Chordoma is another type of cancer that slowly grows into nearby bones and many soft tissues in the spine, ranging from the ... Chordomas have around a 40% metastasis rate and mainly spread to the lungs. (rare cases) soft-tissue sarcoma causes: ... "Chordoma". Genetics Home Reference. Retrieved 2020-04-23. "Undifferentiated pleomorphic sarcoma - Symptoms and causes". Mayo ...
Lopes A, Rossi BM, Silveira CR, Alves AC (1996). "Chordoma: retrospective analysis of 24 cases". Sao Paulo Medical Journal = ... Hirsch EF, Ingals M (May 1923). "Sacrococcygeal chordoma". JAMA: The Journal of the American Medical Association. 80 (19): 1369 ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
Virchow was the first to describe and name diseases such as leukemia, chordoma, ochronosis, embolism, and thrombosis. He coined ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... Hirsch, Edwin F (1923). "Sacrococcygeal Chordoma". JAMA. 80 (19): 1369-1370. doi:10.1001/jama.1923.02640460019007. ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
"Understanding Chordoma - Chordoma Foundation". www.chordomafoundation.org. Retrieved 7 April 2017. King, Christine, BVSc, ... The sacrum is one of the main sites for the development of the sarcomas known as chordomas that are derived from the remnants ...
The evidence regarding brachyury's role in chordoma includes: Brachyury is highly expressed in all chordomas except for the ... A germline SNP in brachyury is present in 97% of chordoma patients. Somatic amplifications of brachyury are seen in a subset of ... Brachyury is implicated in the initiation and/or progression of a number of tumor types including chordoma, germ cell tumors, ... Brachyury is the most selectively essential gene in chordoma relative to other cancer types. Brachyury is associated with a ...
The cells are the likely precursors to a rare cancer called chordoma. Research into the notochord has played a key role in ... Pillai S, Govender S (2018). "Sacral chordoma : A review of literature". J Orthop. 15 (2): 679-684. doi:10.1016/j.jor.2018.04. ... Implications for Disk Degeneration and Chordoma Formation". Developmental Dynamics. 237 (12): 3953-3958. doi:10.1002/dvdy.21805 ...
Magrini SM, Papi MG, Marletta F, Tomaselli S, Cellai E, Mungai V, Biti G (Apr 1993). "Chordoma-natural history, treatment and ...
"Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma". U.S. National Institutes of Health. June 2022. " ... chordoma. "Erbitux- cetuximab solution". DailyMed. 27 September 2021. Retrieved 2 June 2022. "Erbitux EPAR". European Medicines ...
Chordomas, a rare bone tumour, might suggest defects in homologous recombination and mutations affecting HR-related genes. ... April 2019). "Defective homologous recombination DNA repair as therapeutic target in advanced chordoma". Nature Communications ...
Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". ...
The clivus is also the site for chordoma, a rare type of cancer. Surgery for lesions involving the clivus and surrounding ...
José Enrique was diagnosed with chordoma, a rare brain tumour, in May 2018. On 23 June 2018, he announced that he was ...
... a chordoma, or a chordoid meningioma. In particular, meningiomas are known to produce musical auditory hallucinations such as ...
Howard Copeland, 75, American politician, member of the Virginia House of Delegates (1981-1995), chordoma. Vijay Dev, 78, ...
"Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base (HIT-1)". ClinicalTrials.gov. ... Damien Weber (2016). "Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated ... Jinpeng Zhou (2018). "Comparison of the Effectiveness of Radiotherapy with Photons and Particles for Chordoma After Surgery: A ... These include, among others, uveal melanoma (ocular tumor), skull base and paraspinal tumor (chondrosarcoma and chordoma), and ...
Younessi had survived four bouts of cancer since an initial diagnosis of malignant chordoma in 2009. "EWP: Catalog & Student ...
Expanded Endoscopic Endonasal Approach for Resection of Intradural Chordoma: Surgical and Anatomic Nuances: 2-Dimensional ...
... is an American biomedical scientist researching the genetics of dysplastic nevus syndrome and chordoma, and ... Her research interests include the genetics of dysplastic nevi syndrome and chordoma, and etiologic heterogeneity of breast ... Yang identified the first susceptibility gene for familial chordoma-a germline duplication of the T gene that had eluded ...
PMID 18580797 Fraser JF, Nyquist GG, Moore N., Anand VK, Schwartz TH; Endoscopic endonasal transclival resection of chordomas: ...
Copeland was diagnosed with chordoma in August 2016, and died of the disease on April 11, 2019, aged 75. Ress, Dave (April 15, ...
BCRT funds research into primary bone cancer, in particular, osteosarcoma, Ewing's sarcoma, chondrosarcoma, chordoma, spindle ...
Techniques such as endoscopic endonasal surgery are used in pituitary tumors, craniopharyngiomas, chordomas, and the repair of ...
This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical ... and clival chordomas (CHO). They looked at gross total resection and cerebrospinal fluid (CSF) leaks, neurological death, post- ...
Case Series of Ultrasonic Navigated Osteotomy for the Treatment of Spinal Chordomas. World Neurosurg. 2021 Mar 8:S1878-8750(21) ... Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy. World Neurosurg. 2020 Nov;143:319-324. ...
"Development of first immunotherapy to treat chordoma, a rare bone cancer." "Medical Oncology Service". Center for Cancer ...
... and Chordoma. The for-profit spin-off companies M4K Pharma (Medicines for Kids), M4ND Pharma (Medicines for Neurological ...
Tuấn Anh announced his break from singing and WanBi revealed that he had reduced eyesight as a side effect from the chordoma ...
The following list includes types of primary bone cancer: Osteosarcoma Chondrosarcoma Ewing's Sarcoma Adamantinomas Chordomas ...
Tennis announced in his column of November 19, 2009, that he has been diagnosed with a chordoma, a rare malignant tumor that ...
In laymans terms, chordoma is a type of spinal cancer. Chordomas can arise from bone in the skull base and anywhere along the ... Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. In 2015 the first consensus guidelines for the ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ... Expert Recommendations for the Diagnosis and Treatment of Chordoma is a handbook produced by the Chordoma Foundation, which ...
Chordoma is a rare type of cancer that affects the spine. Treatments include surgery, chemotherapy, and radiation therapy. ... Chordoma may result from genetic changes. About 80% of individuals with chordoma have a genetic variation in a gene responsible ... In some cases, chordoma tumors may return after surgical treatment. A 2021 study. showed the location of chordoma affects the ... The proper chordoma treatment depends on the person and whether the cancer has spread. Some chordoma treatments include: * ...
Chordoma are midline tumors originating from embryonic remnants of the primitive notochord. They are considered to be low-grade ... Chordomas occur in the midline along the spinal axis from the clivus to the sacrum, anterior to the spinal cord. Chordomas are ... Morphology of chordoma. Contrast-enhanced sagittal T1-weighted spin-echo image. Chordoma of the upper part of the clivus with ... Morphology of chordoma. Contrast-enhanced sagittal T1-weighted spin-echo image. Chordoma of the upper part of the clivus with ...
We offer resources specific to Israel to help guide your chordoma journey ... Chordoma Connections Chordoma Connections is a private, online community where chordoma patients and their loved ones can come ... Making sense of chordoma and how to deal with it can be a real challenge. Every day we speak with chordoma patients and their ... Understanding chordoma Learn more about the symptoms, locations, and types of chordoma tumors. ...
We are pleased to announce the results of the Chordoma Research Grants competition, conducted in partnership with the Chordoma ... Results of the July 2018 Chordoma Research Grants Competition. We are pleased to announce the results of the Chordoma Research ... Out of a total of 5 grant applications, 2 Canadian Cancer Society Chordoma Research Grants have been approved - a 40% success ... For the first time, we are pleased to announce the results of the Chordoma Research Grants competition, conducted in ...
... as part of the Chordoma Foundations Drug Screening Program. Information on the specific PDX and CDX models used for drug ...
JHC7 chordoma-engrafted rats showed smaller tumors confined to the bone periphery compared with UCH1 chordoma-engrafted rats. ... OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and ... To the authors knowledge, this is the first spine rodent model of human chordoma. Its use and further study will be essential ... Currently, there are no rodent models of spinal chordoma. In the present study, the authors sought to develop and characterize ...
Overview Of Skull Base Chordoma A Chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the ... Sacrococcygeal Chordoma Clival Chordoma Familial Chordoma Spinal Chordoma Infantile Spinal Muscular Atrophy ... Skull Base Chordoma. Overview Of Skull Base Chordoma. A Chordoma is a rare type of cancerous tumor that can occur anywhere ... A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. A chordoma that ...
... vestigate the outcome of PCA in a selected cohort of patients with sacrococcygeal chordoma, with a minimum of 5 years follow‐up ... Chordoma is a rare malignant tumor of the axial skeleton. Percuta- neous cryoablation (PCA) is a minimally invasive technique ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Ranked list of diseases related to "chordoma"Drugs, active principles and "chordoma"Medicinal plantsQuestions and answers from ... Chordoma. A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, ...
Chordoma Foundation. Attn: Tammy Silverthorne. PO Box 2127. Durham, NC 27702. [email protected]. (919) 809-6779. If you believe ... The Chordoma Foundation will use arbitration to resolve any problems.. CHORDOMA FOUNDATION ONLINE COMMUNITY TERMS OF USE. ... The Chordoma Foundation Marks. The Chordoma Foundation, the Chordoma Foundation logo, and other Chordoma Foundation logos and ... The Chordoma Foundations Liability. You use the Chordoma Foundation Online Community at your own risk. The Chordoma Foundation ...
Here are some ways to be part of Giving Tuesday with the Chordoma Foundation:. *Host a fundraiser. Fundraisers can be hosted ... De Chordoma Foundation is door de IRS erkend als een 501(c)(3) non-profit organisatie, en donaties zijn fiscaal aftrekbaar voor ... Make a donation. If we all contribute what we can, powerful new chordoma treatments are not only possible, but probable. ... 2024 Chordoma Foundation. Alle rechten voorbehouden. Toestemmingsvoorkeuren , Privacy policy , Terms of use ...
Chords for Chordoma Videos. Chords for Chordoma Videos. Here are some videos from our event on November 9, 2017 at the Lyric ... Chords for Chordoma Jazz at the Lyric , A Pan American Jazz Event. The band is comprised of Memo Acevedo (percussion), Pat ... Canadian Chordoma Network - Toronto - Ontario. Steven Golick [email protected] , Tobi Liederman tobi@ ...
A Fundação Chordoma é reconhecida pela Receita Federal como uma organização sem fins lucrativos 501(c)(3), e as doações são ... 2024 Chordoma Foundation. Todos os direitos reservados. Preferências de Consentimento , Privacy policy , Terms of use ... A Chordoma Foundation valoriza sua privacidade e não venderá ou compartilhará suas informações com nenhuma outra organização. ... Eu li e aceito os Termos de Uso e Política de Privacidade da Chordoma Foundation ...
Hereby, we established and characterized a novel human PTEN-deleted chordoma cell line (CH3) from a primary skull base chordoma ... Hereby, we established and characterized a novel human PTEN-deleted chordoma cell line (CH3) from a primary skull base chordoma ... However, isolation and maintenance of chordoma cell lines are challenging and PTEN-deleted chordoma cell lines are exceedingly ... However, isolation and maintenance of chordoma cell lines are challenging and PTEN-deleted chordoma cell lines are exceedingly ...
Büyükdere Mah. Prof. Dr. Nabi AVCI Bulvarı No: 4 Posta Kodu: 26040 ...
Age at diagnosis, tumor size and disease stage can influence conditional survival for patients with chordoma. The HR of ... The conditional 5-year disease-specific survival in patients with regional or localized chordoma was relatively stable over ... Therefore, understanding the changing risk profile and conditional 5-year DSS of chordoma is critical for accurate clinical ... In total, 1942 patients with chordoma were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) ...
Pembrolizumab monotherapy for advanced chordoma. Hu, Xianglin; Wang, Chunmeng; Huang, Wending; Barber, Sean M; Yan, Wangjun. ...
Chordoma UK is a registered charity spreading awareness of chordoma and raising funds to support chordoma research in the UK. ... Chordoma UK is a registered charity (RCN 1173201) Registered Office: The Long Barn. Down Farm, Cobham Park Road, Cobham, Surrey ... If you have any questions about Chordoma UK, or would like to talk to someone about cancer, send us an email and well get back ... Individual donations and gifts may be made directly to Chordoma UK and enhanced through GIFT AID. Your fundraising can benefit ...
Cytopathological Dilemma of Anaplastic Sacral Chordoma with Radiological and Histological Corroboration ... Anaplastic chordoma or dedifferentiated chordoma, an even rarer variant, can cause a diagnostic confusion with chondrosarcoma ... Chordoma is a relatively rare locally invasive and potentially malignant tumor of fetal notochord origin, affecting the axial ... We present a case of anaplastic sacral chordoma in a man 59 years of age, causing extensive destruction of sacrum and invading ...
Extraosseous chordomas are extremely rare. In this case report, we describe an extraosseous chordoma in the coccygeal region ... N2 - Extraosseous chordomas are extremely rare. In this case report, we describe an extraosseous chordoma in the coccygeal ... AB - Extraosseous chordomas are extremely rare. In this case report, we describe an extraosseous chordoma in the coccygeal ... abstract = "Extraosseous chordomas are extremely rare. In this case report, we describe an extraosseous chordoma in the ...
Chordoma. *Pediatric oncology. *Pediatric tumors. *Proton Beam Therapy. *Proton radiation for breast cancer ...
Chordoma. *Chorea-acanthocytosis. *Choreoacanthocytosis, see Chorea-acanthocytosis. *Choreoathetosis self-mutilation syndrome, ...
Chordoma. NCCN recommendations for treatment of chordoma are as follows [1] :. * Enrollment in a clinical trial should be ... Dedifferentiated chordomas are treated according to soft tissue sarcoma management guidelines and chemotherapy can be used ... With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should ...
Chordoma of the sacrum en bloc total sacretomy and lumbopelvic reconstruction Varga Peter Pal MD, Professor National Center for ... Chordoma of the sacrum en bloc high p.... Chordoma of the sacrum en bloc high partial sacretomy Varga Peter Pal MD, Professor ... Chordoma of the sacrum en bloc total sacretomy and lumbopelvic reconstruction Dorsal access Stabilization / Correction • 21m ... Chordoma of the sacrum en bloc total sacretomy and lumbopelvic reconstruction Varga Peter Pal MD, Professor National Center for ...
Sheppard HE, DallAgnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS…
Sclerotic lumbar chordoma: A case report. Ansari O, Anand R, Serdynski KC, Aktan S, Ploussard B, Allam E. Ansari O, et al. ...
A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. Case ... A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. Case ... A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. Case ... A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. Case ...
From: Economics of the Management of Craniospinal Chordoma and Chondrosarcoma and the feasibility of the bundled payment model ...
... chondrosarcoma-myeloma-ewing-s-sarcoma-chordoma-adamantinoma-extraskeletal-osteosarcoma-giant-cell-tumor-chordoma-chondroma- ... Bone and cartilage disease spectrum (Osteosarcoma,Chondrosarcoma,Myeloma,Ewings sarcoma,Chordoma,Adamantinoma,Extraskeletal ... Bone and cartilage disease spectrum (Osteosarcoma,Chondrosarcoma,Myeloma,Ewings sarcoma,Chordoma,Adamantinoma,Extraskeletal ... osteosarcoma,Giant cell tumor,Chordoma,Chondroma,Fibrous dysplasia,Aneurysmal bone cyst) )and adjacent normal bone tissue ...
  • Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. (wikipedia.org)
  • Anaplastic chordoma or dedifferentiated chordoma, an even rarer variant, can cause a diagnostic confusion with chondrosarcoma from the cytopathological point of view, with similar chondromyxoid matrix and atypical cells. (turkjpath.org)
  • Hence, chordoma bearing anaplastic features needs to be identified and should be distinguished from chondrosarcoma on aspiration cytopathology. (turkjpath.org)
  • With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
  • In the latest version of the guidelines released in November 2020, surgery is the main treatment for chondrosarcoma, chordoma, and giant cell tumor of bone, which can be combined with radiotherapy or targeted therapy. (bvsalud.org)
  • Sacral chordoma is presented with chronic low back pain. (wikipedia.org)
  • mTOR signaling is hyperactive in sporadic sacral chordomas: in one study 10 out of 10 sacral chordomas exhibited phosphorylation of Ribosomal protein s6 and EIF4EBP1 by immunohistochemistry Partial or complete PTEN (gene) deficiency is observed in nearly all sacral chordomas In a study of 49 chordomas Akt, TSC2, and EIF4EBP1 were phosphorylated in 92%, 96% and 98% of cases, respectively. (wikipedia.org)
  • Sacral chordomas make up 2 to 4% of all primary bone tumours and 44% of all primary sacral tumours, thus making it the most common malignant sacral tumour. (wikipedia.org)
  • Males aged between 40 and 50 years are twice as more common than women to get sacral chordoma. (wikipedia.org)
  • Chordomas are distributed as follows: 50% sacral, 35% skull base, and 15% in the vertebral bodies of the mobile spine (most commonly the C2 vertebrae, followed by the lumbar spine and then the thoracic spine). (medscape.com)
  • Uri Melzer was diagnosed with sacral chordoma in March 2021, at the age of 63. (chordomafoundation.org)
  • Scholars@Duke publication: Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. (duke.edu)
  • We present a case of anaplastic sacral chordoma in a man 59 years of age, causing extensive destruction of sacrum and invading the paravertebral tissues as evidenced by radiology. (turkjpath.org)
  • In some cases, chordoma tumors may return after surgical treatment. (medicalnewstoday.com)
  • Chordomas are midline tumors originating from embryonic remnants of the primitive notochord. (medscape.com)
  • Clival chordomas represent less than 0.2% of all intracranial tumors. (medscape.com)
  • Chordomas account for approximately 3% of all bone tumors. (medscape.com)
  • RESULTS The spine tumors displayed typical chordoma morphology, that is, physaliferous cells filled with vacuolated cytoplasm of mucoid matrix. (duke.edu)
  • JHC7 chordoma-engrafted rats showed smaller tumors confined to the bone periphery compared with UCH1 chordoma-engrafted rats. (duke.edu)
  • Skull base chordomas comprise fewer than 1 percent of tumors affecting the brain and spinal cord. (illness.com)
  • In layman's terms, chordoma is a type of spinal cancer. (wikipedia.org)
  • Chordoma is a rare cancer that affects spinal tissue. (medicalnewstoday.com)
  • About 80% of individuals with chordoma have a genetic variation in a gene responsible for spinal development. (medicalnewstoday.com)
  • Chordomas occur in the midline along the spinal axis from the clivus to the sacrum, anterior to the spinal cord. (medscape.com)
  • Currently, there are no rodent models of spinal chordoma. (duke.edu)
  • As the chordoma grows, it puts pressure on the adjacent areas of the brain or spinal cord, leading to the signs and symptoms of the disorder. (illness.com)
  • Regression of cervical spinal cord compression in a patient with chordoma following treatment with cetuximab and gefitinib. (lu.se)
  • A 2021 study showed the location of chordoma affects the likelihood that it will recur. (medicalnewstoday.com)
  • [ 5 ] Chordoma is the most common primary malignant tumor found in the sacrum. (medscape.com)
  • Approximately half of all chordomas occur at the base of the spine (sacrum), about one third occur in the base of the skull (occiput), and the rest occur in the cervical (neck), thoracic (upper back), or lumbar (lower back) vertebrae of the spine. (illness.com)
  • Chordoma of the sacrum en bloc high p. (oot-esj.com)
  • Management of locally recurrent chordoma of the mobile spine and sacrum: A systematic review. (bvsalud.org)
  • One 2018 study suggests that proton therapy is an effective treatment for people with chordoma. (medicalnewstoday.com)
  • Chordomas can arise from bone in the skull base and anywhere along the spine. (wikipedia.org)
  • Chordoma is a slow-growing and extremely rare cancer of the spine that typically affects older adults. (medicalnewstoday.com)
  • If a doctor suspects chordoma, they will order imaging tests to examine the area along the spine. (medicalnewstoday.com)
  • Chordoma is a form of cancer that occurs along the spine. (medicalnewstoday.com)
  • 22 of the 34 rats were engrafted in the lumbar spine with human chordoma. (duke.edu)
  • To the authors' knowledge, this is the first spine rodent model of human chordoma. (duke.edu)
  • A Chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. (illness.com)
  • A chordoma anywhere along the spine may cause pain, weakness, or numbness in the back, arms, or legs. (illness.com)
  • Chordomas are considered to be low-grade neoplasms, locally aggressive, and slow-growing but highly recurrent. (medscape.com)
  • The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. (wikipedia.org)
  • On magnetic resonance imaging (MRI) scans, chordomas show a signal heterogeneity, possibly due to a variety of components, including fluid and gelatinous mucoid substance (associated with recent and old hemorrhage) and necrotic areas within the tumor (see the following images). (medscape.com)
  • Age at diagnosis, tumor size and disease stage can influence conditional survival for patients with chordoma. (biomedcentral.com)
  • Chordoma is a relatively rare locally invasive and potentially malignant tumor of fetal notochord origin, affecting the axial skeleton. (turkjpath.org)
  • There are three histological variants of chordoma: conventional, chondroid and dedifferentiated. (wikipedia.org)
  • Chondroid chordomas appear to have a more indolent clinical course. (wikipedia.org)
  • In addition to conventional chordomas, chondroid chordomas, which are composed of cartilaginous hyaline tissue, have shorter T1- and T2-weighted MRI signals because of low water content. (medscape.com)
  • Introduction: En bloc resection of high-cervical chordomas is a technically challenging procedure associated with significant morbidity. (elsevierpure.com)
  • A limited number of reported cases of en bloc resection of high-cervical chordomas have been reported in the literature. (elsevierpure.com)
  • Conclusions: Labiomandibular glossotomy for approach to high anterior cervical chordomas followed by craniospinal reconstruction to the clivus with an expandable cage represents a novel technique for managing high cervical chordomas. (elsevierpure.com)
  • A resemblance exists between notochordal and chordoma cells morphologically and immunohistochemically. (medscape.com)
  • Chordomas are rare primary malignant tumours of notochordal origin usually arising along the axial skeleton with particular predilection of the skull base and sacrococcygeal region. (unicatt.it)
  • About 50 to 60% of chordomas are located in the sacrococcygeal region. (wikipedia.org)
  • A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. (illness.com)
  • Duplications or increases in activity (expression) of the TBXT gene have also been identified in people with skull base chordoma who have no history of the disorder in their family. (illness.com)
  • Some people with skull base chordoma do not have changes in the TBXT gene, and the cause of the disorder in these individuals is unknown. (illness.com)
  • Hereby, we established and characterized a novel human PTEN-deleted chordoma cell line (CH3) from a primary skull base chordoma. (unicatt.it)
  • He was recommended an en-bloc resection in Israel, which was not a favorable option due to the quality of life issues that could arise after the surgery. (chordomafoundation.org)
  • OBJECTIVE Chordoma is a slow-growing, locally aggressive cancer that is minimally responsive to conventional chemotherapy and radiotherapy and has high local recurrence rates after resection. (duke.edu)
  • Differential diagnosis between chordoma and invasive pituitary adenoma. (medscape.com)
  • Albeit usually slow-growing, chordomas can be aggressive mostly depending on their invasive behaviour and according to different histotypes and molecular alterations, including TBXT duplication and SMARCB1 homozygous deletion. (unicatt.it)
  • citation needed] In the United States, the annual incidence of chordoma is approximately 1 in one million (300 new patients each year). (wikipedia.org)
  • In 2015 the first consensus guidelines for the diagnosis and treatment of chordoma were published in The Lancet Oncology. (wikipedia.org)
  • About 1 in 1 million people receive a chordoma diagnosis each year. (medicalnewstoday.com)
  • If MRI and CT scans indicate the presence of chordoma, a doctor may perform a biopsy to confirm the diagnosis. (medicalnewstoday.com)
  • On average, people with chordoma live for about 10 years after diagnosis. (medicalnewstoday.com)
  • Cytopathological diagnosis of chordoma is favored by the presence of characteristic physaliphorous cells, bearing abundant foamy cytoplasm dispersed in a myxoid matrix. (turkjpath.org)
  • In four of these families, duplication of the brachyury gene was found to be responsible for causing chordoma. (wikipedia.org)
  • The specific mechanism by which excess brachyury protein contributes to the development of chordomas is unclear. (illness.com)
  • As chordoma develops slowly, symptoms may not occur right away. (medicalnewstoday.com)
  • Chordomas typically occur in adults between ages 40 and 70. (illness.com)
  • There are lots of opportunities for each of us affected by chordoma to fuel research advances that will dramatically improve treatments and outcomes. (chordomafoundation.org)
  • When you give to the Chordoma Foundation on Giving Tuesday, you're helping to bring about better treatments, care, and experiences for people affected by chordoma. (chordomafoundation.org)
  • If we all contribute what we can, powerful new chordoma treatments are not only possible, but probable. (chordomafoundation.org)
  • In rare cases these cells begin to grow and divide uncontrollably, invading the nearby bone and soft tissue and resulting in the development of a chordoma. (illness.com)
  • This pathway is targeted by mTOR inhibitors and the availability of in vitro models of chordoma cells will aid in further investigating this issue. (unicatt.it)
  • CH3 cells were sensitive to Rapamycin treatment suggesting that mTOR inhibitors may represent a valuable option for patients suffering from PTEN-deleted chordomas. (unicatt.it)
  • Pathology showed physaliphorous cells and the immunohistochemical staining pattern typical of chordoma. (tmu.edu.tw)
  • One 2019 study compared the 10-year survival rates of people with chordoma after surgery alone versus surgery combined with radiation. (medicalnewstoday.com)
  • To evaluate the conditional survival of patients with chordoma to potentially help physician planning of optimal cancer surveillance and guide better clinical decisions. (biomedcentral.com)
  • Since anaplastic chordoma bears an unfavorable prognosis, it should be suspected on preoperative aspiration cytopathology. (turkjpath.org)
  • Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. (wikipedia.org)
  • Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. (wikipedia.org)
  • Chordomas are rare, occurring in approximately 1 per million individuals each year. (illness.com)
  • However, isolation and maintenance of chordoma cell lines are challenging and PTEN-deleted chordoma cell lines are exceedingly rare. (unicatt.it)
  • Extraosseous chordomas are extremely rare. (tmu.edu.tw)
  • One was a chordoma, a rare type of bone cancer, and the other was a squamous cell carcinoma of the head and neck. (medscape.com)
  • This video demonstrates "en bloc" sacrectomy with safe oncological margins below S1, with no lumbopelvic stabilization in. (oot-esj.com)
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  • We are pleased to announce the results of the Chordoma Research Grants competition, conducted in partnership with the Chordoma Foundation. (cancer.ca)
  • Funds committed to this competition have been made possible through a community-driven partnership with the Chordoma Foundation and generous donors and volunteers across the country. (cancer.ca)
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  • The proper chordoma treatment depends on the person and whether the cancer has spread. (medicalnewstoday.com)
  • There is no single treatment that is right for every person with chordoma. (medicalnewstoday.com)
  • In this booklet, you will find information about how chordoma is diagnosed and tests to get before treatment. (chordomafoundation.org)
  • From finding the right care team to understanding treatment options to getting emotional support, there are a number of practical challenges that most everyone affected by chordoma will face at one time or another. (chordomafoundation.org)
  • We can help answer your questions, provide information about treatment guidelines, help you find qualified doctors, and connect you with others in the chordoma community. (chordomafoundation.org)
  • Therefore, understanding the changing risk profile and conditional 5-year DSS of chordoma is critical for accurate clinical treatment guidance. (biomedcentral.com)
  • Chordomas grow slowly, gradually extending into the bone and soft tissue around them. (illness.com)
  • There are no drugs currently approved to treat chordoma, however a clinical trial conducted in Italy using a tyrosine kinase inhibitor imatinib demonstrated a modest response in some chordoma patients. (wikipedia.org)
  • Computed tomography scan of 2 patients with chordoma. (medscape.com)
  • Every day we speak with chordoma patients and their loved ones looking for answers to important questions. (chordomafoundation.org)
  • In total, 1942 patients with chordoma were identified and extracted from Surveillance, Epidemiology, and End Results (SEER) databases (1973-2015). (biomedcentral.com)
  • The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered. (wikipedia.org)
  • Erlotinib-like EGFR inhibitors have been also reported to be effective in chordoma. (wikipedia.org)
  • A chordoma that occurs in the tailbone (coccygeal chordoma) may result in a lump large enough to be felt through the skin and may cause problems with bladder or bowel function. (illness.com)
  • An inherited duplication of the TBXT gene identified in a few families is associated with an increased risk of developing a chordoma. (illness.com)
  • Changes in the TBXT gene have been associated with chordoma. (illness.com)
  • In a tissue microarray containing 21 chordomas Platelet-derived growth factor receptor-beta (PDGFR-b), epidermal growth factor receptor (EGFR), KIT (CD117) and HER2 were detected in 100%, 67%, 33% and 0% of cases, respectively. (wikipedia.org)