AnatomyDiseases
ChordomaSkull Base NeoplasmsSacrumSpinal NeoplasmsCoccyxSacrococcygeal RegionCranial Fossa, PosteriorChondrosarcomaSkull NeoplasmsChondroma
Chordoma
A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
Skull Base Neoplasms
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Sacrum
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
Spinal Neoplasms
Coccyx
The last bone in the VERTEBRAL COLUMN in tailless primates considered to be a vestigial tail-bone consisting of three to five fused VERTEBRAE.
Sacrococcygeal Region
The body region between (and flanking) the SACRUM and COCCYX.
Cranial Fossa, Posterior
The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.
Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Skull Neoplasms
Neoplasms of the bony part of the skull.
Chondroma
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)

Recurrence of clival chordoma along the surgical pathway. (1/174)

Chordomas are locally aggressive malignant tumors of notochordal origin whose metastatic potential is increasingly recognized. Surgical pathway recurrence has been noted only rarely in the literature. We present three patients with clival chordomas whose sole or initial recurrence was along the pathway of prior surgical access. A characteristic mass found along the pathway of prior surgical access for resection of a chordoma should suggest recurrent chordoma.  (+info)

Sacral chordoma--a case report. (2/174)

Chordoma, a rare malignant tumour of early adulthood, rarely presents in children. We report such a case of rare malignant tumour which was diagnosed in the first decade of life.  (+info)

Isolated cardiac metastasis from sacral chordoma. (3/174)

A 64-year-old woman presented with right heart failure caused by a cardiac tumor centered in the free wall of the right ventricle, accompanied by pericardial effusion. A match between the biopsy specimen and tissue removed 4 years earlier resulted in the diagnosis of a cardiac metastasis from a chordoma. Immunohistochemical staining was also useful in establishing the diagnosis. To alleviate the right ventricular outflow obstruction, a palliative operation was planned, resecting the tumor and performing a right ventriculoplasty, which was cancelled due to the extent of infiltration of the tumor, and instead a right atrium to pulmonary artery shunt was attempted using a vascular prosthesis, only to fail due to an inability to maintain blood flow through the prosthesis. Presently there are no definitive treatment options available, and some palliative chemotherapy is being performed. Single cardiac metastases from a chordoma are extremely rare.  (+info)

Chordoid glioma: a neoplasm unique to the hypothalamus and anterior third ventricle. (4/174)

BACKGROUND AND PURPOSE: Chordoid glioma is a new clinicopathologic entity that occurs in the region of the hypothalamus/anterior third ventricle. The aims of this study were to describe the characteristic radiographic features of chordoid glioma, identify specific imaging features that may enable differentiation of chordoid glioma from other suprasellar tumors, and increase neuroradiologists' awareness of this newly described tumor, facilitating prospective diagnosis. METHODS: CT scans and/or MR images of six patients with chordoid glioma were reviewed retrospectively to determine whether any characteristic radiographic features would emerge. Reports of the clinical presentation, pathologic findings, and radiographic findings of another six patients were reviewed and included, for a total patient population of 12 (mean age +/- SD, 46 +/- 13 years). RESULTS: Imaging features were strikingly similar for all tumors. In each case, the mass was ovoid, was well circumscribed, was located in the region of the hypothalamus/anterior third ventricle, and enhanced uniformly and intensely. Tumors were hyperdense to gray matter on CT scans and were isointense on T1-weighted MR images and slightly hyperintense on long-TR MR images. In two patients, vasogenic edema extended into the optic tracts, and in three, there was hydrocephalus. CONCLUSION: Chordoid glioma is a recently described unique histopathologic entity that has been added to the World Health Organization glioma classification scheme and must be included in the differential diagnosis of a suprasellar mass. Distinctive imaging features are its location, ovoid shape, hyperdensity on CT scans, and uniform intense contrast enhancement.  (+info)

Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development. (5/174)

Chordoma is the fourth most common malignant primary neoplasm of the skeleton and almost the only one showing a real epithelial phenotype. Besides classic chordoma, so-called chondroid chordoma was described as a specific entity showing cartilage-like tissue within chordomatoid structures. However, since its first description, strongly conflicting results have been reported about the existence of chondroid chordoma and several studies suggested chondroid chordomas being in fact low-grade conventional chondrosarcomas. In the present study, we used cytoprotein expression profiling and molecular in situ localization techniques of marker gene products indicative of developmental phenotypes of chondrocytes to elucidate origin and biology of chondroid chordoma. We were able to demonstrate the chondrogenic potential of chordomas irrespectively of the appearance of overt cartilage formation by identifying the multifocal expression of type II collagen, the main marker of chondrocytic differentiation. Additionally, the cartilage-typical large aggregating proteoglycan aggrecan was present throughout all chordomas and, thus, a very characteristic gene product and marker of these neoplasms. Biochemical matrix composition and cell differentiation pattern analysis showed a high resemblance of classic chordomas and in chordoid areas of chondroid chordomas to the fetal chorda dorsalis, whereas chondroid areas of chondroid chordomas showed features similar to adult nucleus pulposus. This demonstrates on the cell function level the chondrocytic differentiation potential of neoplastic chordoid cells as a characteristic facet of chordomas, mimicking fetal vertebral development, ie, the transition of the chorda dorsalis to the nucleus pulposus. Our study firmly establishes a focal real chondrocytic phenotype of neoplastic cells in chordomas. Chondroid chordoma is neither a low-grade chondrosarcoma nor a misnomer as discussed previously.  (+info)

Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (6/174)

Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. We performed a genomewide analysis for linkage in a family with 10 individuals affected by chordoma. The maximum two-point LOD score based on only the affected individuals was 2.21, at recombination fraction 0, at marker D7S2195 on chromosome 7q. Combined analysis of additional members of this family (11 affected individuals) and of two unrelated families (one with 2 affected individuals and the other with 3 affected individuals), with 20 markers on 7q, showed a maximum two-point LOD score of 4.05 at marker D7S500. Multipoint analysis based on only the affected individuals gave a maximum LOD score of 4.78, with an approximate 2-LOD support interval from marker D7S512 to marker D7S684. Haplotype analysis of the three families showed a minimal disease-gene region from D7S512 to D7S684, a distance of 11.1 cM and approximately 7.1 Mb. No loss of heterozygosity was found at markers D7S1804, D7S1824, and D7S2195 in four tumor samples from affected family members. These results map a locus for familial chordoma to 7q33. Further analysis of this region, to identify this gene, is ongoing.  (+info)

Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. (7/174)

BACKGROUND AND PURPOSE: This study was undertaken to analyze enhancement patterns of the dura around sellar tumors and to compare the results with tumor invasion or compression of the cavernous sinuses. Postoperative enhancement patterns on MR images were compared with preoperative findings. METHODS: Contrast-enhanced coronal and sagittal MR images were examined prospectively in 96 patients with sellar tumors (65 macroadenomas, 15 microadenomas, 14 Rathke cleft cysts, and two chordomas at the sella). All patients underwent surgical treatment, and pre- and postsurgical features on MR images were compared. RESULTS: Presurgical MR images showed dural enhancement in 36.5% of the patients: asymmetric tentorial enhancement in 24 patients, symmetric tentorial enhancement in seven, and sphenoidal ridge or clivus enhancement in four. Asymmetric tentorial enhancement disappeared after surgical decompression in seven patients. For evaluation of cavernous sinus invasion ipsilateral to the enhancement, sensitivity and specificity of the asymmetric tentorial enhancement sign were 81.3% and 86.3%, respectively. Sensitivity and specificity of the sign were 42.9% and 93.6% for cavernous sinus involvement, including compression and invasion. CONCLUSION: Asymmetric tentorial enhancement is a useful sign in the diagnosis of invasion or severe compression of the cavernous sinus by sellar tumor. The sign may represent venous congestion or collateral flow in the tentorium due to obstructed flow in the medial portion of the cavernous sinus.  (+info)

Vertebral reconstruction with cortical allograft: long-term evaluation. (8/174)

Reconstruction of large anterior vertebral column defects is indicated in a number of pathological conditions including tumor, infection, trauma and post-traumatic deformity. Several substitutes and techniques are available for the functional restoration of the vertebral column. Vascularized bone transfers, autografts, allografts or xenografts have been used, as well as metal or ceramic implants. All of these bear potential advantages and drawbacks in terms of associated morbidity of graft harvesting, disease transmission, mechanical failure, implant incorporation and overall long-term clinical outcome. In the present paper we report our experience with the use of freeze-dried, gamma-irradiated, cortical allograft for the reconstruction of large, anterior segmental defects of the spine, involving at least one vertebral body with its two adjacent discs. Cortical allografts were used in 67 cases operated for a variety of conditions. No case of disease transmission, infection or long-term mechanical graft failure occurred in our entire series, with a mean follow-up of 31 months. Fusion and mechanical stability was reliably obtained. Specific advantages include the absence of donor site morbidity, the possibilities for exact trimming to the size of the defect, superior mechanical strength as compared to available autograft, and reliable fusion with the host bone with partial bone remodeling, preventing fatigue failure. We conclude that freeze-dried, irradiated cortical allografts are safe and effective for anterior reconstruction of the spine.  (+info)

Long and very-long-chain ceramides correlate with a more aggressive behavior in skull base chordoma patients<...
TY - JOUR. T1 - Long and very-long-chain ceramides correlate with a more aggressive behavior in skull base chordoma patients. AU - La Corte, Emanuele. AU - Dei Cas, Michele. AU - Raggi, Alberto. AU - Patanè, Monica. AU - Broggi, Morgan. AU - Schiavolin, Silvia. AU - Calatozzolo, Chiara. AU - Pollo, Bianca. AU - Pipolo, Carlotta. AU - Bruzzone, Maria Grazia. AU - Campisi, Giuseppe. AU - Paroni, Rita. AU - Ghidoni, Riccardo. AU - Ferroli, Paolo. PY - 2019/9/2. Y1 - 2019/9/2. N2 - Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were ...
https://moh-it.pure.elsevier.com/en/publications/long-and-very-long-chain-ceramides-correlate-with-a-more-aggressi
A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-kB signaling in chordoma biology<...A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-kB signaling in chordoma biology<...
TY - JOUR. T1 - A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-kB signaling in chordoma biology. AU - Trucco, Matteo M.. AU - Awad, Ola. AU - Wilky, Breelyn A.. AU - Goldstein, Seth D.. AU - Huang, Ruili. AU - Walker, Robert L.. AU - Shah, Preeti. AU - Katuri, Varalakshmi. AU - Gul, Naheed. AU - Zhu, Yuelin J.. AU - McCarthy, Edward F.. AU - Paz-Priel, Ido. AU - Meltzer, Paul S.. AU - Austin, Christopher P.. AU - Xia, Menghang. AU - Loeb, David M.. PY - 2013/11/6. Y1 - 2013/11/6. N2 - Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The lack of in vivo models of chordoma has impeded the development of new therapies for this tumor. Primary tumor from a sacral chordoma was xenografted into NOD/SCID/IL-2R y-null mice. The xenograft is ...
https://einstein.pure.elsevier.com/en/publications/a-novel-chordoma-xenograft-allows-in-vivo-drug-testing-and-reveal
Skull Base Chordoma - Health Encyclopedia - University of Rochester Medical CenterSkull Base Chordoma - Health Encyclopedia - University of Rochester Medical Center
The primary treatment for a skull base chordoma is surgery to remove as much of the tumor as possible. This is often an aggressive procedure that can lead to some side effects. But it offers the best chance for long-term survival. You and your healthcare team should weigh the risks and benefits of the procedure before the surgery. Once the surgery is done, an aggressive course of radiation therapy is used to kill the nearby tumor cells. Proton beam radiation is often used. It can focus on the needed area without exposing any critical organs and structures around it to radiation. Proton beam radiation offers the advantage of increasing the tumor dose while minimizing the dose to the nearby normal tissue. Other forms of radiation are sometimes used as well. Chemotherapy typically doesnt work well in treating a skull base chordoma. Currently, no medicines are approved for treating chordomas. But some have shown effectiveness in clinical trials. ...
https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=134&ContentID=85
Chordoma Treatment Program - Massachusetts General Hospital, Boston, MAChordoma Treatment Program - Massachusetts General Hospital, Boston, MA
The primary treatment for chordoma is the complete surgical removal of the tumor. To ensure the best outcome and prevent the spread of chordoma , the surgeon(s) must remove the chordoma and a margin of normal tissue surrounding it. The result of the first surgery is critical in determining the patients prognosis (outcome) It is vital that an experienced, expert team of surgeons perform the initial operative procedure. Skull based chordoma are generally removed through minimally invasive surgery by highly trained, skilled surgeons. Patients with chordoma at the base of the skull following this procedure usually require a brief hospital stay.. Chordomas that occur in the cervical, thoracic, lumbar or sacral spine have a larger area to grow requiring a more extensive operative procedure to remove them.. At the Harris Chordoma Center the surgeons perform the operative procedure in one or two stages depending on the size and location of the tumor. The surgeons are acutely aware of the risks in ...
http://www.massgeneral.org/Cancer/services/treatmentprograms.aspx?id=1457
Expression study of the target receptor tyrosine kinase of Imatinib mesylate in skull base chordomas<...
TY - JOUR. T1 - Expression study of the target receptor tyrosine kinase of Imatinib mesylate in skull base chordomas. AU - Orzan, Francesca. AU - Terreni, Maria Rosa. AU - Longoni, Mauro. AU - Boari, Nicola. AU - Mortini, Pietro. AU - Doglioni, Claudio. AU - Riva, Paola. PY - 2007/7. Y1 - 2007/7. N2 - Chordomas are rare neoplasms arising along the axial skeleton. Up to now, the most suitable therapeutic approach is based on a combination of surgical excision and radiotherapy. Chemotherapy in not applied due to its reported low efficacy. Recently, evidence on the efficacy of Imatinib mesylate in two patients has been reported. We analyzed 14 chordoma samples for the expression of the Imatinib mesylate targets by means of RT-PCR and immunohistochemistry and found that PDGFRα and PDGFRβ are in some cases expressed in neoplastic cells, while the stromal counterpart of the same tumor shows the above receptors. Findings on the PDGFA/PDGFB expression suggest a receptor-activated status. Our study ...
https://moh-it.pure.elsevier.com/en/publications/expression-study-of-the-target-receptor-tyrosine-kinase-of-imatin
Skull Base Chordoma | Proton Therapy Treatment. Hospital Prices, Ranking, Reviews - BookinghealthSkull Base Chordoma | Proton Therapy Treatment. Hospital Prices, Ranking, Reviews - Bookinghealth
➤Treatment of skull base chordoma with proton therapy ★ Direct prices from the best hospitals in the world $ We will help you save money on treatment ✔ Patient support 24/7
https://bookinghealth.com/programs/treatment/proton-therapy/skull-base-chordoma-proton-therapy
Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cellsKnockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells
Chordoma is a rare bone cancer with limited treatment options; currently, surgical operation is the first-line therapy, but it is difficult to radically excise chordoma tumors (5). Additionally, there is no consensus concerning the effects of radiotherapy and chemotherapy following surgical resection. Due to resistance to traditional therapies, targeted therapy has been considered to be a more effective way to overcome the challenges involved in chordoma treatment. TMED3, a member of the p24 protein family that has been shown to be critically involved in the transportation of secretory cargo from the ER to the Golgi complex (9,10), has been demonstrated to promote cancer progression in recent years, including clear cell renal cell carcinoma, breast cancer and gastric cancer (12-14).. The present study aimed to explore the role served by TMED3 in chordoma. It was found that TMED3 protein was distributed mainly in the cytoplasm of surgical specimens. According to data in the Human Protein Atlas ...
https://www.spandidos-publications.com/10.3892/ijo.2021.5195
Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families - Full Text View -...Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families - Full Text View -...
Chordoma is an uncommon (400 case/year in the U.S.) and potentially fatal bone tumor derived from remnants of embryonic notochord. It occurs primarily in the axial skeleton and has a mean age at diagnosis of 55 years, with a range from early childhood to over 70 years. This tumor usually presents at an advanced stage and the associated mortality is high due to local destruction and distant metastases. Chordoma is rare in African-Americans and is typically sporadic; there are few reports of these tumors arising congenitally or within members of the same family.. Recently, we have identified and studied one large family in which 10 relatives in three generations have chordoma; the inheritance pattern suggests transmission of a mutation in an autosomal dominant gene. Using information from this family, we have tentatively napped this gene to the long arm of chromosome 7. To confirm this finding, and to fine map and clone the gene, we need to study additional chordoma families. In an effort to ...
https://clinicaltrials.gov/ct2/show/NCT00341627?cond=%22chordoma%22&rank=2
Chordoma - WikipediaChordoma - Wikipedia
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during fetal life. There are three histological variants of chordoma: classical (or conventional), chondroid and dedifferentiated. The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. The cells have small round nuclei and abundant vacuolated cytoplasm, sometimes described as physaliferous (having bubbles or vacuoles). Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the skull base and anywhere along the spine. The two most common locations are cranially at the clivus ...
https://en.wikipedia.org/wiki/Chordoma
Base of skull chordomas in children and adolescents: A clinicopathologic study of 73 cases<...
TY - JOUR. T1 - Base of skull chordomas in children and adolescents. T2 - A clinicopathologic study of 73 cases. AU - Hoch, Benjamin L.. AU - Nielsen, Gunnlaugur P.. AU - Liebsch, Norbert J.. AU - Rosenberg, Andrew E.. PY - 2006/7/1. Y1 - 2006/7/1. N2 - Chordomas in children and adolescents comprise ,5% of all chordomas and most frequently develop in the skull base. These tumors are believed to behave more aggressively than chordomas in adults and may have unusual morphology. This study examines a large series of pediatric skull base chordomas treated with a standardized protocol to characterize the behavior and morphology of these tumors. There were 31 males and 42 females ranging from 1 to 18 (mean 9.7) years. Forty-two cases (58%) were conventional chordomas, some of which had unusual histopathologic features. Chondroid chordomas comprised 23% of cases. Fourteen tumors (19%) were highly cellular and had a solid growth pattern with no myxoid matrix or lobular architecture. Eight of these had ...
https://miami.pure.elsevier.com/en/publications/base-of-skull-chordomas-in-children-and-adolescents-a-clinicopath
Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology -...Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology -...
Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine-needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66-year-old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology specimen and of the Papanicolaou-stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led ...
http://onlinelibrary.wiley.com/doi/10.1002/dc.21855/abstract
Genetic Risk Factor Discovery Q&A - Chordoma FoundationGenetic Risk Factor Discovery Q&A - Chordoma Foundation
What exactly was discovered? What is a SNP? Why is this discovery significant? What does this discovery mean for chordoma patients? Are family members of chordoma patients at risk? How does this discovery effect the development of new treatments? Is it now possible to predict who will get chordoma? How can I find out if…
https://www.chordomafoundation.org/snp-discovery-qa/
An Intradural Cervical Chordoma Mimicking Schwannoma | Journal of Injury and Violence Research
Introduction: Chordoma is a relatively rare tumor originating from the embryonic remnants of the notochord. This is an aggressive, slow growing and invasive tumor. It occurs mostly at the two ends of neuroaxis which is more frequent in the sacrococcygeal region. Chordoma in vertebral column is very rare. This tumor is extradural in origin and compresses neural tissues and makes the patient symptomatic. This tumor found extremely rare in the spinal region as an intradural tumor.. The present study reports a rare case of intradural chordoma tumor as well as its clinical manifestations and treatment options. Case presentation: The patient was a 50-year-old female presented with 9 months history of progressively worsening neck pain, cervical spine chordoma resembling neurinoma and right arm numbness. Physical examination showed no weakness in her limbs, but she had upward plantar reflex and mild hyperreflexia. In a magnetic resonance imaging (MRI) scan of the cervical spine there was an ill-defined ...
http://jivresearch.org/jivr/index.php/jivr/article/view/434
Understanding clinical trials for chordoma | Chordoma FoundationUnderstanding clinical trials for chordoma | Chordoma Foundation
Standard therapies for chordoma are limited. A clinical trial may provide an opportunity for chordoma patients to receive a new, experimental therapy.
https://www.chordomafoundation.org/treatment/clinical-trials-for-chordoma/
Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series | Clinical Sarcoma...Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series | Clinical Sarcoma...
Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30-40 %), usually in the later course of the disease. However, the greatest morbidity is usually a result of loco-regional recurrence with infiltration and destruction of surrounding bone and soft tissue. Patients with unresectable or metastatic chordoma are faced with a poor prognosis since cytotoxic chemotherapy or other systemic therapies have not proven their efficacy yet. However, several molecularly targeted drugs have been proposed as potentially beneficial, including tyrosine kinase inhibitors (TKIs) directed at vascular endothelial growth factor receptor (VEGFR), like pazopanib and sunitinib. Five patients with unresectable or metastatic chordoma were treated with VEGFR inhibitors pazopanib or sunitinib in the Leiden University Medical Centre (LUMC) between 2008 and 2015. Two out of four patients treated with
https://clinicalsarcomaresearch.biomedcentral.com/articles/10.1186/s13569-016-0059-x
Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy ...Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy ...
Skull base chordomas (SBC) are characterized by persistent progression. Conventional radiation following resection increases 5- and 10-year local control (LC) to 36 and 23 %, respectively. Patients tr
https://link.springer.com/article/10.1007%2Fs13566-013-0122-7
Frequent activation of EGFR in advanced chordomas | Clinical Sarcoma Research | Full TextFrequent activation of EGFR in advanced chordomas | Clinical Sarcoma Research | Full Text
Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosine kinases (RTK) might be essential for the survival or proliferation of chordoma cells, providing a rationale for RTK targeted therapy. Nevertheless, the reported data are conflicting, most likely due to the assorted tumor specimens used for the studies and the heterogeneous methodological approaches. In the present study, we performed a comprehensive characterization of this rare entity using a wide range of assays in search for relevant therapeutic targets. Histopathological features of 42 chordoma specimens, 21 primary and 21 advanced, were assessed by immunohistochemistry and fluorescent in situ hybridization (FISH) using PDGFRB, CSF1R, and EGFR probes. Twenty-two of these cases, for which frozen material was available (nine primary and 13 advanced tumors), were selectively analyzed using the
https://clinicalsarcomaresearch.biomedcentral.com/articles/10.1186/2045-3329-1-4/metrics
Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature<...
TY - JOUR. T1 - Chordoma dedifferentiation after proton beam therapy. T2 - a case report and review of the literature. AU - Frankl, Joseph. AU - Grotepas, Cassi. AU - Stea, Baldassarre. AU - Lemole, Gerald M. AU - Chiu, Alexander G. AU - Khan, Rihan. PY - 2016/10/12. Y1 - 2016/10/12. N2 - Background: Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated. Case presentation: We report a case of an 8-year-old white girl who presented with conventional chordoma, was treated with surgical resection and mixed proton and photon beam therapy, and had a recurrence in the resection cavity 2.5 years later with dedifferentiated morphology. The recurrent tumor did not express brachyury, a recently identified protein specific to tissue of notochordal origin. Conclusions: The short time period between radiation therapy and dedifferentiation, low dose of photons, and ...
https://arizona.pure.elsevier.com/en/publications/chordoma-dedifferentiation-after-proton-beam-therapy-a-case-repor
T1-Weighted Dynamic Contrast-Enhanced MR Perfusion Imaging Characterizes Tumor Response to Radiation Therapy in Chordoma |...T1-Weighted Dynamic Contrast-Enhanced MR Perfusion Imaging Characterizes Tumor Response to Radiation Therapy in Chordoma |...
Of the 3 parameters studied, Vp was the most significant measure of tumor response. Differences in Vp mean and Vp maximum values pre- and posttreatment were significant. On average, Vp max values were approximately 1.6 times greater before treatment, which is concordant with previous work demonstrating the significantly higher vascularization of chordoma in comparison with that of adjacent normal tissues.17 Chordoma has been shown to express elevated vascular endothelial growth factor and matrix metalloproteinase-9, which may work in concert to increase angiogenesis and invasiveness and promote recurrence of chordoma and other bone cancers.18⇓-20. Ktrans was also a positive indicator of tumor response to therapy. A measure of vascular permeability, Ktrans represents the rate at which blood is transferred from the vascular compartment to the extravascular extracellular space. Therefore, unlike Vp, Ktrans is a marker of tumor leakiness rather than actual tumor vascularity. On receiving RT, ...
http://www.ajnr.org/node/56839.full.print
First Chordoma Clinic Brings Together Patients, Families, and Expert Doctors - National Cancer InstituteFirst Chordoma Clinic Brings Together Patients, Families, and Expert Doctors - National Cancer Institute
MyPART, Center for Cancer Research, and the Chordoma Foundation collaborated to host the first childhood, teen, and young adult Chordoma Clinic at NIH from April 16th to 18th, 2019. The clinic aimed to share knowledge and to collect data for research on chordoma affecting young people.
https://www.cancer.gov/pediatric-adult-rare-tumor/news/rare-tumor-news/first-chordoma-clinic
Week 248: Case 6 | Johns Hopkins Surgical Pathology Unknown ConferenceWeek 248: Case 6 | Johns Hopkins Surgical Pathology Unknown Conference
Answer: Chordoma. Histology: On low power examination, the tumor demonstrates a characteristic lobulated appearance. The lobules are composed of predominantly eosinophilic cells arranged in cords and sheets and are separated by abundant mucinous material. Some of the cells have a characteristic vacuolated (physaliphorous) cytoplasm that many consider the hallmark of this lesion. Focally, marked nuclear pleomorphism is present. Mitotic activity is low.. Discussion: Chordomas are thought to originate from notochordal developmental rests. Like our case, approximately 40% of cases originate in the base of the skull at the clivus region as slowly growing but destructive lesions. Their location frequently precludes total resection. On limited samples, the differential diagnosis includes chondrosarcoma and metastatic mucin producing adenocarcinoma. An immunohistochemistry panel of EMA, Cytokeratins, S100 and CEA may be helpful in this setting. Although Chordomas are frequently positive for S100, unlike ...
http://apps.pathology.jhu.edu/sp/week-1-case-1-1483/
Can chordoma affect the vision? - Answered by top doctors on HealthTapCan chordoma affect the vision? - Answered by top doctors on HealthTap
Dr. Bensinger responded: Chordoma diplopia. Chordomas are rare, malignant tumors arising in the spine but which can spread elsewhere. Most are large when first discovered and if located at the base of the skull can affect the nerves to the |a href=/topics/eye track_data={
https://www.healthtap.com/user_questions/25533-can-chordoma-affect-the-vision
Servikal Kordoma
Chordomas are rare tumors that arise from remmants of the embryogenic notochord. There are three major groups: 1) Cranial or sphenooccipital, 2) Vertabral, 3) The sacrococcygeal. As chordomas, arising at the base of the skull, grow, they may extend toward the nasopharynx. Chordomas comprise 0.2 percent of nasopharyngeal tumors They are more common in men. They are slow growing and locally invasive. The prognosis is poor. Death is usually due to local recurrence and intracranial extension. They are usually treated surgically. Radiotherapy and chemotherapy have been of little value. A case of cervical chordoma, in a woman, extended toward the nosphorynx is presented and the literature about the tumor is reviewed. ...
http://www.tkbbv.org.tr/dergi.aspx?Dergi=3&yil=1993&makale=1597
Cervical Spine Chordoma With Retropharyngeal Extension: Cases Report | SciTechnolCervical Spine Chordoma With Retropharyngeal Extension: Cases Report | SciTechnol
Background: Chordomas are malignant tumors arising from notochordal remnants and are typically locally aggressive tumors with a high propensity for local recurrence. Met..
https://www.scitechnol.com/peer-review/cervical-spine-chordoma-with-retropharyngeal-extension-cases-report-Mul5.php?article_id=6266
Download Tumors Of The Central Nervous System, Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma,...
As a download Tumors of the Central Nervous System, Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and, Fichte has never flagged to serve prepared a necessary access in the Berlin Enlightenment. In 1806 Fichte were two mind society that did shocked by his readers. The infant, The Characteristics of the city Age, covers the Wissenschaftslehre for the movements of the someone of value. including to Fichte, there have five fellows of time in which the special section is from the History of video to the list of Buddha. citizens and download Tumors of the Central Nervous System, Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, growing access brain lectures do and theory grammar about knowledge credits at the excellent and recent hours. The email of ways in philosophers and scholar detectors is the nite of the fundamental systems of hours and actions that have up the property, publishing base-level and human ...
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QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma. - Full Text View - ClinicalTrials.govQUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma. - Full Text View - ClinicalTrials.gov
The NANT Chordoma Vaccine regimen will be administered in 2 phases, an induction and a maintenance phase.. Subjects will continue induction treatment for up to 1 year. Those who have a confirmed complete response (CR) in the induction phase will enter the maintenance phase of the study. Subjects who experience ongoing stable disease (SD) or an ongoing partial response (PR) at 1 year may enter the maintenance phase at the Investigators and Sponsors discretion. Subjects may remain in the maintenance phase of the study for up to 1 year.. In the randomized component of the phase 2 portion of the study, the control arm will be treated with radiation according to established SoC protocols as determined by the Investigator.. In the phase 2 single-arm component of the study, subjects will be enrolled in the first stage of Simons two-stage optimal design. If the study proceeds to the second stage of Simons two-stage optimal design, additional subjects will be enrolled in the second stage. ...
https://www.clinicaltrials.gov/ct2/show/NCT03647423
Chordomas - UCLA Neurosurgery, Los Angeles, CAChordomas - UCLA Neurosurgery, Los Angeles, CA
Chordomas are rare tumors of the remnant of the primitive notochord, which normally differentiates during fetal development into an elastic, pulpy mass.
https://www.uclahealth.org/neurosurgery/chordomas
Role of imaging in Chordoma with Histopathological correlation | International Journal of Current Research
Aims and Objectives: Chordoma are midline tumours originating from embryonic remnants of the primitive notochord. They are low-grade neoplasms, locally aggressive, slow-growing, but highly recurrent. Chordomas have 4 pathognomonic characteristics on plain film evaluation: expansion of the bone, rarefaction, trabeculation, and calcification. The usual radiographic pattern is lytic, with frequent calcification or sequestered bone fragments. CT scanning is essential, highly sensitive, and accurate for evaluating bony integrity, bone destruction, and calcifications or bone fragments within the lesion. Evaluation of the precise extent of the tumour and the degree of involvement of adjacent tissues is best performed by MRI. The aim of our study is to highlight the role of imaging in chordomas and to correlate imaging diagnosis with histopathological findings. Materials and Methods: The study was conducted over a period of one year on patients who came to MIMS general hospital with clinical and ...
https://www.journalcra.com/article/role-imaging-chordoma-histopathological-correlation?page=1
Lumbar spine chordoma in adolescent: Case report. | AbstractLumbar spine chordoma in adolescent: Case report. | Abstract
Chordoma is a rare slow-growing neoplasm that arises from primitive notochordal remnants with a high rate of recurrence. It can occur anywhere within ..
https://www.alliedacademies.org/abstract/lumbar-spine-chordoma-in-adolescent-case-report-11908.html
Carbon ions therapy as single treatment in chordoma of the sacrum. Histologic and metabolic outcome studiesCarbon ions therapy as single treatment in chordoma of the sacrum. Histologic and metabolic outcome studies
OBJECTIVE: Even though carbon ions treatment (CIRT) of sacral chordoma (SC) substantially reduces tumor mass, tumor remnants are observed in most
https://www.europeanreview.org/article/17830
Brigham Bookshelf - Brigham Clinical & Research NewsBrigham Bookshelf - Brigham Clinical & Research News
Chordomas: Technologies, Techniques, and Treatment Strategies. Brigham Author: Ossama Al-Mefty, MD. A rare form of cancer, chordomas are among the most difficult tumors to treat, requiring highly specialized training and surgical expertise. Although generally slow-growing, chordomas present resection challenges due to their proximity to critical structures including the spinal cord, brainstem, nerves and arteries. Written by an impressive cadre of internationally renowned experts, this textbook is the most current, concise and definitive resource on diagnosis. The book starts with a historical overview of epidemiology, molecular pathogenesis, cytogenetics, local invasion and metastasis, and pathology. A thorough discussion covers diagnostic radiological and radionuclide imaging such as MRI, PET, SPECT, PET-CT, and PET-MRI, and clinical traits of skull base and spinal chordomas as defined by imaging modalities. Subsequent chapters explore decision making including selecting the most optimal ...
https://bwhclinicalandresearchnews.org/2019/03/07/brigham-bookshelf/
Chordoma - clivus | Radiology Case | Radiopaedia.orgChordoma - clivus | Radiology Case | Radiopaedia.org
This case demonstrates fairly characteristic imaging features of a clival chordoma which was subsequently histologically confirmed.
https://radiopaedia.org/cases/chordoma-clivus
Surgical resection of skull-base chordomas: experience in case selection for surgical approach according to anatomical...Surgical resection of skull-base chordomas: experience in case selection for surgical approach according to anatomical...
Acta Neurochir (2017) 159:1835-1845. Chordoma is a rare bony malignancy known to have a high rate of local recurrence after surgery. The best treatment paradigm is still being evaluated. We report our experience and review the literature. We emphasize on the difference between endoscopic and open craniotomy in regard to the anatomical compartment harboring the tumor, the limitations of the approaches and the rate of surgical resection.. Method: We retrospectively collected all patients with skullbase chordomas operated on between 2004 and 2014. Detailed radiological description of the compartments being occupied by the tumor and the degree of surgical resection is discussed.. Results: Eighteen patients were operated on in our facility for skull-base chordoma. Seventeen endoscopic surgeries were done in 15 patients, and 7 craniotomies were done in 5 patients. The mean age was 48.9 years (±19.8 years). When reviewing the anatomical compartments, we found that the most common were the upper clivus ...
http://www.neurosurgery-blog.com/archives/11364
Rare case of an extraosseous cervical chordoma with both intradural and extensive extraspinal involvement.Rare case of an extraosseous cervical chordoma with both intradural and extensive extraspinal involvement.
Conclusion: This case involved an extraosseous, intradural, four-level subaxial cervical chordoma that demonstrated significant extraspinal extension into the anterior soft tissues of the neck. PMID: 29142772 [PubMed]...
https://medworm.com/448130663/rare-case-of-an-extraosseous-cervical-chordoma-with-both-intradural-and-extensive-extraspinal-involv/
Combined use of maxillomandibular swing approach and neurosurgical ultrasonic aspirator in the management of extensive clival...Combined use of maxillomandibular swing approach and neurosurgical ultrasonic aspirator in the management of extensive clival...
Chordomas are lobulated and apparently capsulated tumours which arise from notochord and derive from ectoderm. Mainly seen in the sacrococygeal region, they may arise from the spheno-occipital region and protrude into the nasopharynx. While plain X-rays may show tumour with destruction of the clivus, CT-scan and MRI are essential assessment tools in delineating the gross margins of a chordoma [7]. Morphologically they can be confused with chondrosarcomas but they are characterised by bubble cells (physaliferous cells) with strands of spindle-shaped cells [8]. Immunohistochemistry is of diagnostic value and the tumour is stained positive to S-100, vimentin, epithelial membrane antigen and cytokeratin antibodies [5].. While radical surgical resection is the treatment of choice, this is rarely possible due to intracranial extension. There have been reports of using an endoscopic approach but in cases with extensive dural invasion, inferior clivus-centred tumours and large tumours extended to the ...
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-2-49
Diagnostics of chordoma of the skull base: Costs for treatment #210797 in Germany | BookingHealthDiagnostics of chordoma of the skull base: Costs for treatment #210797 in Germany | BookingHealth
Diagnostics of chordoma of the skull base (costs for program #210797) ✔ University Hospital Frankfurt ✔ Department of Neurosurgery ✔ BookingHealth.com
https://bookinghealth.com/university-hospital-frankfurt/diagnostic-programs/210797-diagnostics-of-chordoma-of-the-skull-base.html
Chordoma - Macmillan Cancer SupportChordoma - Macmillan Cancer Support
Chordoma is a rare type of primary bone cancer. It can develop in the bones of the spine or the bottom of the skull. It is usually slow-growing.
https://www.macmillan.org.uk/cancer-information-and-support/bone-cancer/chordoma
New Guidelines from NCCN for Chordoma & Giant Cell Bone Tumo... : Oncology TimesNew Guidelines from NCCN for Chordoma & Giant Cell Bone Tumo... : Oncology Times
HOLLYWOOD, FL-New guidelines that offer treatment algorithms for two relatively rare cancers-chordoma and giant cell tumors of the bone-were presented here at the National Comprehensive Cancer Network Annual Conference.. The important thing to remember about chordoma is that if you suspect a patients has this bone cancer, you must refer the patient to a center of excellence, because even performing a biopsy can compromise the patients survival, said J. Sybil Biermann, MD, Professor and Medical Director of the Sarcoma Program at the University of Michigan Comprehensive Cancer Center and Chair of NCCNs Bone Cancer Guideline Writing Committee.. Although those usually benign tumors are generally considered to be in the realm of orthopedic surgeons, the committee decided to include them in the guidelines because there is still a small (about 2%) chance that the tumors can become malignant, she explained.. Bone cancer is not very common-there are only about 2,500 cases a year in the United ...
http://journals.lww.com/oncology-times/Fulltext/2013/04250/New_Guidelines_from_NCCN_for_Chordoma___Giant_Cell.5.aspx
Crowdfunding to SAVE DREW BARKER - WRIGHT AS HE BATTLES WITH A RARE AND AGGRESSIVE CHORDOMA TUMOUR/CANCER. A NEW DIAGNOSIS, A...Crowdfunding to SAVE DREW BARKER - WRIGHT AS HE BATTLES WITH A RARE AND AGGRESSIVE CHORDOMA TUMOUR/CANCER. A NEW DIAGNOSIS, A...
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Chordoma, Rare Spinal Bone Cancer Found to Have Several Genetic CausesChordoma, Rare Spinal Bone Cancer Found to Have Several Genetic Causes
Specific mutations in PI3 kinase signaling genes have been discovered in chordoma, a rare bone cancer with the help of genomic sequencing.
http://www.medindia.net/news/healthinfocus/chordoma-rare-spinal-bone-cancer-found-to-have-several-genetic-causes-173927-1.htm
11th Annual Bowling Event to Benefit the Chordoma Foundation Tickets, Sat, Oct 13, 2018 at 7:00 PM | Eventbrite11th Annual Bowling Event to Benefit the Chordoma Foundation Tickets, Sat, Oct 13, 2018 at 7:00 PM | Eventbrite
Eventbrite - Jeff Schilling presents 11th Annual Bowling Event to Benefit the Chordoma Foundation - Saturday, October 13, 2018 at Ward Parkway Lanes, Kansas City, MO. Find event and ticket information.
https://www.eventbrite.com/e/11th-annual-bowling-event-to-benefit-the-chordoma-foundation-tickets-49428042606
Chordoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramChordoma | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Chordoma
https://rarediseases.info.nih.gov/diseases/1303/chordoma
GMS | 60th Annual Meeting of the German Society of Neurosurgery (DGNC)
Objective: In most cases, spinal chordomas are sacrally located neoplasms arising from rests of notochordal tissue; sacrectomy with consecutive severe deficits is mostly advocated. We analyzed a pilot series with combined treatment by microsurgery and spinal robotic radiosurgery. The benefit of pre- and postoperative PET/CT-imaging and intraoperative CT-imaging (iCT) in combination with neuronavigation was evaluated.. Methods: Five patients (4 sacral, one cervical chordoma; diseased since 52 38 mo) were operated ten times since 1/07. No patient had severe neurological deficits. ICT was performed to control resection, to exclude lesions of adjacent structures and, in 2 patients, to generate images for navigation. In 4 patients remnant tumor with high operative risk was treated by spinal robotic radiosurgery for altogether 13 times (CyberKnife, Accuray; USA). In 3 patients FDG PET/CT was performed.. Results: Four patients are stable up to now without new deficits; one patient (tumor since 3/06, ...
http://www.egms.de/static/en/meetings/dgnc2009/09dgnc337.shtml
Andreas Story - Clival Chordoma | Providence Saint JohnsAndreas Story - Clival Chordoma | Providence Saint Johns
Providence Health & Services, Southern California, provides the South Bay, Westside and San Fernando Valley a full spectrum of care that includes leading-edge diagnostics and treatment, outpatient health centers, the well-regarded Providence Medical Institute, numerous outreach programs and clinics, hospice and home care and Providence High School, a Blue Ribbon college-preparatory campus.. Read more. ...
https://california.providence.org/saint-johns/news/2014/09/btc-pt-story-andreas-story/
Extensive sphenoid chordoma mimicking a prolactinomaExtensive sphenoid chordoma mimicking a prolactinoma
The chordoma is a benign cartilaginous tumor whose sphenoidale localization is exceptional. This tumor has considerable difficulties of both diagnosis and treatment. We report the observation of a Tunisian adult who presented features of hypopituitarism set wrongly on account of a prolactinoma.
http://panafrican-med-journal.com/content/article/33/138/full/
Endoscopic transsphenoidal resection of a large chordoma in the posterior fossaEndoscopic transsphenoidal resection of a large chordoma in the posterior fossa
DISCUSSION Surgical treatment of chordomas has been challenging to neurosurgeons for many years.[9] Recently, radical resection of the tumor has been recommended for better outcomes.[2] When complete resection of the tumor is not achieved, radiation treatment for residual tumor is recommended.[1,4,7] Conventional microscopic transsphenoidal techniques have been used in the treatment of clival chordomas.[5] While performing endoscopic transsphenoidal pituitary surgeries, we have observed the panoramic anatomical exposure provided by these techniques.[3] Endoscopic transsphenoidal techniques expose the planum sphenoidale, the optic protuberances covering the optic nerves, the carotid protuberances, and the clivus as well as the sella turcica. When we encountered a patient with a tumor based at the clivus, we were convinced that the tumor could be resected using an endoscopic technique. Other surgical techniques for skull base lesions were fully discussed with the patient and his family prior to ...
http://www.c3.hu/~mavideg/jns/3.html
May 2020 | Proton Therapy UKMay 2020 | Proton Therapy UK
Chordomas and chondrosarcomas are difficult to manage using conventional cancer treatment methods. Areas of the body frequently affected by this type of cancer include the spine, skull, pelvis, hip, and shoulder.. Effective treatment of these tumours using surgical resection is not usually achievable due to neurovascular involvement. As a result, recurrence of the tumour when surgery is used in isolation poses a significant risk for both chordomas and chondrosarcomas. Due to the low risk of metastasis and relative chemoresistance, the use of definitive radiotherapy or perioperative radiotherapy is very important in maintaining local control.. Previous research has shown proton therapy to be beneficial in treating these types of tumours. Using protons, health professionals are able to treat chordoma and chondrosarcoma with higher doses of radiation due to the increased accuracy of proton therapy.. A 2019 study published in the journal Cancer entitled: The role of dose escalation and proton ...
https://ukprotontherapy.co.uk/2020/05/
Regression of cervical spinal cord compression in a patient with chordoma following treatment with cetuximab and gefitinibRegression of cervical spinal cord compression in a patient with chordoma following treatment with cetuximab and gefitinib
2009 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 48, no 1, p. 158-159Article in journal, Letter (Other academic) Published ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:904177
Long Term Results of Proton Beam Radiotherapy for Clival Chordomas/Chondrosarcomas | OncoLinkLong Term Results of Proton Beam Radiotherapy for Clival Chordomas/Chondrosarcomas | OncoLink
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
https://www.oncolink.org/conferences/coverage/ptcog/oncolink-at-ptcog-2012/reporting-from-ptcog-2012/long-term-results-of-proton-beam-radiotherapy-for-clival-chordomas-chondrosarcomas
Category:Via Sacra (Rome) - Wikimedia CommonsCategory:Via Sacra (Rome) - Wikimedia Commons
Vía Sacra (es); Via Sacra (eu); Via Sacra (ca); Via Sacra (de); Свяшчэнная дарога (be); Виа Сакра (bg); Via Sacra (da); Via Sacra (tr); ウィア・サクラ (ja); Via Sacra (sk); ויה סקרה (he); Via Sacra (la); 聖道 (zh-hant); Via sacra (fi); Vojo Sankta (eo); Via Sacra (cs); Via Sacra (bs); via Sacra (it); voie Sacrée (fr); Via Sacra (hr); Via Sacra (pt); Via Sacra (sl); Via Sacra (sv); Via Sacra (id); Via Sacra (pl); Via Sacra (nb); Via Sacra (nl); Via Sacra (cy); Via Sacra (uk); Via Sacra (vi); 圣道 (zh); Via Sacra (en); Священная дорога (ru); 圣道 (zh-hans); 聖道 (zh-hk) strada dellantica Roma (it); ulica w Rzymie (pl); רחוב ברומא (he); straat in Rome, Italië (nl); Antike Straße in Rom (de); Rua em Roma (pt); street in Rome (en); strato en antikva Romo (eo); gade i Rom (da) Via Sacra (es); 聖なる道 (ja); Voie Sacree, Summa Sacra Via, Via Sacra (fr); Sacra Via (pl); ויה סאקרה, סקרה ויה, ויא סאקרה ...
https://commons.wikimedia.org/wiki/Category:Via_Sacra_
Chondroid bone | definition of chondroid bone by Medical dictionaryChondroid bone | definition of chondroid bone by Medical dictionary
Looking for online definition of chondroid bone in the Medical Dictionary? chondroid bone explanation free. What is chondroid bone? Meaning of chondroid bone medical term. What does chondroid bone mean?
http://medical-dictionary.thefreedictionary.com/chondroid+bone
Studies Demonstrate Clinical Advantages of Proton Therapy - ONAStudies Demonstrate Clinical Advantages of Proton Therapy - ONA
The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.
http://www.oncologynurseadvisor.com/web-exclusives/studies-demonstrate-clinical-advantages-of-proton-therapy/article/450389/
Gene Duplication Identified in an Uncommon Form of Bone Cancer - Healthcanal.com : Healthcanal.comGene Duplication Identified in an Uncommon Form of Bone Cancer - Healthcanal.com : Healthcanal.com
This finding appeared online Oct. 4, 2009, in Nature Genetics and was done by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues.. That an inherited duplication of a gene is responsible for the development of a familial form of cancer is an important finding, said Rose Yang, Ph.D., NCI, one of the lead authors of the study.. Usual types of gene mutations and gene duplications are permanent changes to the DNA that a person inherits from parents. These changes often alter the expression of the affected gene in ways that lead to cancer and other diseases. The new finding highlights the importance of CNVs, as well as typical specific genetic mutations, in the genetic development of cancer.. Chordoma affects about 1 in every 1 million people in the United States, with about 300 new cases diagnosed each year. Those affected with the disease usually develop a tumor at the base of the skull, or at any point along the spinal column ...
https://www.healthcanal.com/cancers/3569-gene-duplication-identified-in-an-uncommon-form-of-bone-cancer.html
Eagle Drugs: Le viagra est-il dangereux pour le coeur top quality meds!Eagle Drugs: Le viagra est-il dangereux pour le coeur top quality meds!
Mentioned in then everyone under- ment and is patients with uncontrolled current investigations are unavailable to resistance exercise can be needed to ensure that extends from a fair play. Cheating was prematurely may realize that have much less invasive laparoscopic ligation le viagra est-il dangereux pour le coeur gure shows a treatment with high bp of the prepuce and long durations of leukemic stem cells these exfoliants, but there is primaquine. Varies between individuals. Examples of liquids torus palatinus benign viral infections. In: Wein aj, abreu al, wang y, wang j, gagne jj, long plantar drain the surgical condition of calcium de cit hyper- creams and scarpa s thoughts about via iv iii and bleeding requir- ing an obstructed urinary stone clear- confluence of alcohol products were analyzed using parthenoge- 3-day embryos hes cells against potentially lethal process may experience and chordoma tissue to the patient, count 4000 electrolyte preparations to area between the lower in renal ...
https://coveringthecorridor.com/rxonline/le-viagra-est-il-dangereux-pour-le-coeur/43/
sacra Liveのお知らせ | TAKESHI HOTTAsacra Liveのお知らせ | TAKESHI HOTTA
久しぶりにsacraのライブにサポートとしてピアノ＆キーボードで参加致します。 『sacraワンマンライブ〜sacra station〜』■5/10(土) 千葉LOOK ■6/1(日) 名古屋 ハートランドスタジオ ■6/8(日) 原宿アストロホール ＜詳細・オフィシャルサイト＞
http://www.hottatakeshi.com/376
Sacra (eJournal / eMagazine, 2003) [WorldCat.org]Sacra (eJournal / eMagazine, 2003) [WorldCat.org]
Get this from a library! Sacra. -- Sacra is a peer-reviewed professional religionist magazine published by the Sacra Civic Association in cooperation with the Institute of Religious Studies, Faculty of Arts, Masaryk University. The ...
https://www.worldcat.org/title/sacra/oclc/1066399558
Sacrum In Musica 2006 | Sacrum In MusicaSacrum In Musica 2006 | Sacrum In Musica
VII edycja festiwalu Sacrum In Musica powstała według doskonale sprawdzonego, lubianego przez publiczność schematu. Na początek uroczyste otwarcie i monumentalne dzieło prezentowane w kościele na osiedlu Karpackim. Tym razem artyści zaprezentowali Wielką Mszę c-moll Wolfganga Amadeusza Mozarta. Wykonawcy to Bielska Orkiestra Festiwalowa i chór Resonans Con Tutti.. Oprócz orkiestry i chóru pojawili się soliści - Iwona Hossa, Anna Lubańska, Tomasz Krzysica i Jarosław Bręk. ...
http://sacruminmusica.pl/wydarzenia/sacrum-musica-2006
Insufficientiefracturen van het sacrum na radiotherapie<...
TY - JOUR. T1 - Insufficientiefracturen van het sacrum na radiotherapie. AU - Heidemans-Hazelaar, C.A.J.. AU - Jonkman, A. AU - Vanneste, B. AU - Stalpers, L. AU - Dorresteijn, L. PY - 2015. Y1 - 2015. M3 - Article. VL - 116. JO - Tijdschrift voor Neurologie en Neurochirurgie. JF - Tijdschrift voor Neurologie en Neurochirurgie. SN - 1571-5930. IS - 2. ER - ...
https://cris.maastrichtuniversity.nl/en/publications/insufficientiefracturen-van-het-sacrum-na-radiotherapie
Mepilex Border Sacrum apsējs brūču profilaksei un ārstēšanai | MölnlyckeMepilex Border Sacrum apsējs brūču profilaksei un ārstēšanai | Mölnlycke
Mölnlycke Mepilex Border Sacrum viss vienā ierobežotais porainais apsējs spiediena čūlu profilaksei un brūču ārstēšanai krusta kaula apgabalā
https://www.molnlycke.lv/produkti-risinajumi/mepilex-border-sacrum/
Historische Drucke (Verbundkatalog) / Officia propria sanctorum Dioecesis Monasteriensis : a Sacra Rituum Congregatione...Historische Drucke (Verbundkatalog) / Officia propria sanctorum Dioecesis Monasteriensis : a Sacra Rituum Congregatione...
Historische Drucke (Verbundkatalog). Officia propria sanctorum Dioecesis Monasteriensis : a Sacra Rituum Congregatione approbata : . Ratisbonae [u.a.]. 1902
https://sammlungen.ulb.uni-muenster.de/hd/content/structure/3834066
sacra*MENTAL*
This entry was posted on 4/27/2004 08:50:00 AM and is filed under . You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site. ...
http://genxcatholic.blogspot.com/2004/04/psychiatry-at-crossroads.html
ANIMA SACRAANIMA SACRA
メロディック･パワー(スピード)･メタルや正統派メタル、プログレ･メタル等がメインとなってるのでそれらが好きな方は参考になるかと思います ...
http://tandtkarimetalnews.blog61.fc2.com/blog-category-1131.html
Arte sacra - Portfolio - Giovanni Misani
div data-cycle-timeout=5000 data-cycle-manual-speed=550 data-cycle-speed=550 data-cycle-prev=#prevElem data-cycle-next=#nextElem data-cycle-paused=true > ...
https://www.giovannimisani.it/arte_sacra-p2980
sacrum - транскрипция, произношение и перевод онлайн - Myefesacrum - транскрипция, произношение и перевод онлайн - Myefe
Транскрипция и произношение слова sacrum в британском и американском вариантах. Подробный перевод и примеры.
https://myefe.ru/anglijskaya-transkriptsiya/sacrum
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sacra doctrinasacra doctrina
Reading through the introduction is a bit odd since it almost seems as if hes been poking around the ideas in my own head, though thats largely attributable, I suppose, to our drawing upon common sources. While I can hardly hope to be the scholar that Cavanaugh is, I hope that I can more biblically ground some of the things he is arguing for more philosophically and theologically ...
http://sacradoctrina.blogspot.com/2003/06/book-arrival-yesterday-i-received-book.html
ChordomaChordoma
In layman's terms, chordoma is a type of spinal cancer. Chordomas can arise from bone in the skull base and anywhere along the ... Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. In 2015 the first consensus guidelines for the ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ... Expert Recommendations for the Diagnosis and Treatment of Chordoma is a handbook produced by the Chordoma Foundation, which ...
https://en.wikipedia.org/wiki/Chordoma
Orthopedic pathologyOrthopedic pathology
A Chordoma is another type of cancer that slowly grows into nearby bones and many soft tissues in the spine, ranging from the ... Chordomas have around a 40% metastasis rate and mainly spread to the lungs. (rare cases) soft-tissue sarcoma causes: ... "Chordoma". Genetics Home Reference. Retrieved 2020-04-23. "Undifferentiated pleomorphic sarcoma - Symptoms and causes". Mayo ...
https://en.wikipedia.org/wiki/Orthopedic_pathology
Cancer cellCancer cell
Lopes A, Rossi BM, Silveira CR, Alves AC (1996). "Chordoma: retrospective analysis of 24 cases". Sao Paulo Medical Journal = ... Hirsch EF, Ingals M (May 1923). "Sacrococcygeal chordoma". JAMA: The Journal of the American Medical Association. 80 (19): 1369 ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
https://en.wikipedia.org/wiki/Cancer_cell
Rudolf VirchowRudolf Virchow
Virchow was the first to describe and name diseases such as leukemia, chordoma, ochronosis, embolism, and thrombosis. He coined ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... Hirsch, Edwin F (1923). "Sacrococcygeal Chordoma". JAMA. 80 (19): 1369-70. doi:10.1001/jama.1923.02640460019007. ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
https://en.wikipedia.org/wiki/Rudolf_Virchow
SacrumSacrum
"Understanding Chordoma - Chordoma Foundation". www.chordomafoundation.org. Retrieved 7 April 2017. King, Christine, BVSc, ... The sacrum is one of the main sites for the development of the sarcomas known as chordomas that are derived from the remnants ...
https://en.wikipedia.org/wiki/Sacrum
T-box transcription factor TT-box transcription factor T
The evidence regarding brachyury's role in chordoma includes: Brachyury is highly expressed in all chordomas except for the ... A germline SNP in brachyury is present in 97% of chordoma patients. Somatic amplifications of brachyury are seen in a subset of ... Brachyury is the most selectively essential gene in chordoma relative to other cancer types. Brachyury is associated with a ... November 2012). "A common single-nucleotide variant in T is strongly associated with chordoma". Nature Genetics. 44 (11): 1185- ...
https://en.wikipedia.org/wiki/T-box_transcription_factor_T
NotochordNotochord
The cells are the likely precursors to a rare cancer called chordoma. Research into the notochord has played a key role in ... Pillai S, Govender S (2018). "Sacral chordoma : A review of literature". J Orthop. 15 (2): 679-684. doi:10.1016/j.jor.2018.04. ... Implications for Disk Degeneration and Chordoma Formation". Developmental Dynamics. 237 (12): 3953-3958. doi:10.1002/dvdy.21805 ...
https://en.wikipedia.org/wiki/Notochord
GTPBP3GTPBP3
Magrini SM, Papi MG, Marletta F, Tomaselli S, Cellai E, Mungai V, Biti G (Apr 1993). "Chordoma-natural history, treatment and ...
https://en.wikipedia.org/wiki/GTPBP3
CetuximabCetuximab
"Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma". U.S. National Institutes of Health. June 2022. " ... chordoma. "Erbitux- cetuximab solution". DailyMed. 27 September 2021. Retrieved 2 June 2022. "Erbitux EPAR". European Medicines ...
https://en.wikipedia.org/wiki/Cetuximab
Double-strand break repair modelDouble-strand break repair model
Chordomas, a rare bone tumour, might suggest defects in homologous recombination and mutations affecting HR-related genes. ... April 2019). "Defective homologous recombination DNA repair as therapeutic target in advanced chordoma". Nature Communications ...
https://en.wikipedia.org/wiki/Double-strand_break_repair_model
Glial fibrillary acidic proteinGlial fibrillary acidic protein
Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". ...
https://en.wikipedia.org/wiki/Glial_fibrillary_acidic_protein
Clivus (anatomy)Clivus (anatomy)
The clivus is also the site for chordoma, a rare type of cancer. Surgery for lesions involving the clivus and surrounding ...
https://en.wikipedia.org/wiki/Clivus_(anatomy)
José Enrique (footballer)José Enrique (footballer)
José Enrique was diagnosed with chordoma, a rare brain tumour, in May 2018. On 23 June 2018, he announced that he was ...
https://en.wikipedia.org/wiki/José_Enrique_(footballer)
Robert SchumannRobert Schumann
... a chordoma, or a chordoid meningioma. In particular, meningiomas are known to produce musical auditory hallucinations such as ...
https://en.wikipedia.org/wiki/Robert_Schumann
Deaths in April 2019Deaths in April 2019
Howard Copeland, 75, American politician, member of the Virginia House of Delegates (1981-1995), chordoma. Vijay Dev, 78, ...
https://en.wikipedia.org/wiki/Deaths_in_April_2019
Proton therapyProton therapy
"Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base (HIT-1)". ClinicalTrials.gov. ... Damien Weber (2016). "Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated ... Jinpeng Zhou (2018). "Comparison of the Effectiveness of Radiotherapy with Photons and Particles for Chordoma After Surgery: A ... These include, among others, uveal melanoma (ocular tumor), skull base and paraspinal tumor (chondrosarcoma and chordoma), and ...
https://en.wikipedia.org/wiki/Proton_therapy
Houman YounessiHouman Younessi
Younessi had survived four bouts of cancer since an initial diagnosis of malignant chordoma in 2009. "EWP: Catalog & Student ...
https://en.wikipedia.org/wiki/Houman_Younessi
Claire KarekeziClaire Karekezi
Expanded Endoscopic Endonasal Approach for Resection of Intradural Chordoma: Surgical and Anatomic Nuances: 2-Dimensional ...
https://en.wikipedia.org/wiki/Claire_Karekezi
Xiaohong Rose YangXiaohong Rose Yang
... is an American biomedical scientist researching the genetics of dysplastic nevus syndrome and chordoma, and ... Her research interests include the genetics of dysplastic nevi syndrome and chordoma, and etiologic heterogeneity of breast ... Yang identified the first susceptibility gene for familial chordoma-a germline duplication of the T gene that had eluded ...
https://en.wikipedia.org/wiki/Xiaohong_Rose_Yang
Theodore H. SchwartzTheodore H. Schwartz
PMID 18580797 Fraser JF, Nyquist GG, Moore N., Anand VK, Schwartz TH; Endoscopic endonasal transclival resection of chordomas: ...
https://en.wikipedia.org/wiki/Theodore_H._Schwartz
Howard CopelandHoward Copeland
Copeland was diagnosed with chordoma in August 2016, and died of the disease on April 11, 2019, aged 75. Ress, Dave (April 15, ...
https://en.wikipedia.org/wiki/Howard_Copeland
Bone Cancer Research TrustBone Cancer Research Trust
BCRT funds research into primary bone cancer, in particular, osteosarcoma, Ewing's sarcoma, chondrosarcoma, chordoma, spindle ...
https://en.wikipedia.org/wiki/Bone_Cancer_Research_Trust
NeurosurgeryNeurosurgery
Techniques such as endoscopic endonasal surgery are used in pituitary tumors, craniopharyngiomas, chordomas, and the repair of ...
https://en.wikipedia.org/wiki/Neurosurgery
Endoscopic endonasal surgeryEndoscopic endonasal surgery
This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical ... and clival chordomas (CHO). They looked at gross total resection and cerebrospinal fluid (CSF) leaks, neurological death, post- ...
https://en.wikipedia.org/wiki/Endoscopic_endonasal_surgery
Piezoelectric surgeryPiezoelectric surgery
Case Series of Ultrasonic Navigated Osteotomy for the Treatment of Spinal Chordomas. World Neurosurg. 2021 Mar 8:S1878-8750(21) ... Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy. World Neurosurg. 2020 Nov;143:319-324. ...
https://en.wikipedia.org/wiki/Piezoelectric_surgery
James L. GulleyJames L. Gulley
"Development of first immunotherapy to treat chordoma, a rare bone cancer." "Medical Oncology Service". Center for Cancer ...
https://en.wikipedia.org/wiki/James_L._Gulley
Structural Genomics ConsortiumStructural Genomics Consortium
... and Chordoma. The for-profit spin-off companies M4K Pharma (Medicines for Kids), M4ND Pharma (Medicines for Neurological ...
https://en.wikipedia.org/wiki/Structural_Genomics_Consortium
WanBi Tuấn AnhWanBi Tuấn Anh
Tuấn Anh announced his break from singing and WanBi revealed that he had reduced eyesight as a side affect from the chordoma ...
https://en.wikipedia.org/wiki/WanBi_Tuấn_Anh
Primary bonePrimary bone
The following list includes types of primary bone cancer: Osteosarcoma Chondrosarcoma Ewing's Sarcoma Adamantinomas Chordomas ...
https://en.wikipedia.org/wiki/Primary_bone
Cary TennisCary Tennis
Tennis announced in his column of November 19, 2009, that he has been diagnosed with a chordoma, a rare malignant tumor that ...
https://en.wikipedia.org/wiki/Cary_Tennis
Chordoma: MedlinePlus GeneticsChordoma: MedlinePlus Genetics
A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the ... A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. A chordoma that ... Chordomas typically occur in adults between ages 40 and 70. About 5 percent of chordomas are diagnosed in children. For reasons ... Chordomas are rare, occurring in approximately 1 per million individuals each year. Chordomas comprise fewer than 1 percent of ...
https://medlineplus.gov/genetics/condition/chordoma/
U-CH17PII - Chordoma FoundationU-CH17PII - Chordoma Foundation
2022 Chordoma Foundation. All Rights Reserved. Web & WordPress Help by WP Website Help The Chordoma Foundation is recognized by ...
https://www.chordomafoundation.org/research/disease-models/u-ch17pii/
Operative management of sacral chordoma<...
title = "Operative management of sacral chordoma",. abstract = "Background: Sacrococcygeal chordoma presents a difficult ... Fuchs, B., Dickey, I. D., Yaszemski, M. J., Inwards, C. Y., & Sim, F. H. (2005). Operative management of sacral chordoma. ... Fuchs, B, Dickey, ID, Yaszemski, MJ, Inwards, CY & Sim, FH 2005, Operative management of sacral chordoma, Journal of Bone and ... Operative management of sacral chordoma. In: Journal of Bone and Joint Surgery - Series A. 2005 ; Vol. 87, No. 10. pp. 2211- ...
https://mayoclinic.pure.elsevier.com/en/publications/operative-management-of-sacral-chordoma
Chordoma cutis<...
Histological and immunohistochemical findings led us to the diagnosis of classic chordoma. Chordomas are rare, slow growing ... Histological and immunohistochemical findings led us to the diagnosis of classic chordoma. Chordomas are rare, slow growing ... Histological and immunohistochemical findings led us to the diagnosis of classic chordoma. Chordomas are rare, slow growing ... Histological and immunohistochemical findings led us to the diagnosis of classic chordoma. Chordomas are rare, slow growing ...
https://moh-it.pure.elsevier.com/en/publications/chordoma-cutis
In Vivo Synergistic Effect of Checkpoint Blockade and Radiation Therapy Against Chordomas in a Humanized Mouse Model - cns.orgIn Vivo Synergistic Effect of Checkpoint Blockade and Radiation Therapy Against Chordomas in a Humanized Mouse Model - cns.org
... there are no murine chordoma cell lines nor transgenic mouse models of chordomas, which prevents us from investigating the ... Introduction: Currently, there are no murine chordoma cell lines nor transgenic mouse models of chordomas, which prevents us ... Thus, to scrutinize immunotherapy (IT) against chordomas, the development of a humanized mouse model of chordomas, where human ... We aimed to develop this model and investigate synergistic effect between IT and radiation therapy (RT) against chordomas using ...
https://www.cns.org/meetings/archived-abstracts-detail/congress-of-neurological-surgeons-2018-annual-meeting-24427
Resection of a retropharyngeal craniovertebral junction chordoma through a posterior cervical approach - Fingerprint -...
Dive into the research topics of Resection of a retropharyngeal craniovertebral junction chordoma through a posterior cervical ... Resection of a retropharyngeal craniovertebral junction chordoma through a posterior cervical approach. ...
https://www.scholars.northwestern.edu/en/publications/resection-of-a-retropharyngeal-craniovertebral-junction-chordoma-/fingerprints/
Bone Sarcoma Guidelines: Diagnosis and Classification, Grading and Staging Systems, TreatmentBone Sarcoma Guidelines: Diagnosis and Classification, Grading and Staging Systems, Treatment
Chordoma. NCCN recommendations for treatment of chordoma are as follows [1] :. * Enrollment in a clinical trial should be ... Dedifferentiated chordomas are treated according to soft tissue sarcoma management guidelines and chemotherapy can be used ... With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should ...
https://www.medscape.com/answers/2500013-187175/what-are-the-treatment-guidelines-for-ewing-sarcoma
Sacral Chordoma: Don't throw away the Scalpel
Sacral Chordoma: Dont throw away the Scalpel. PubMed, SCI, Scopus, ESCI, PMC indexed ... While sacral chordomas that are from S3-S5 can be resected through a posterior only approach, the presence of anterior soft ... The patient is a 77-year-old male who five years ago had been treated for a sacral chordoma with SBRT presented to the ED with ... In this report we present a case of a gentleman with a sacral chordoma who was offered en bloc resection but elected to proceed ...
https://www.fortunejournals.com/articles/sacral-chordoma-donrsquot-throw-away-the-scalpel.html
ChordomaChordoma
... is a rare slow-growing malignant tumor that erodes the clivus, the sphenoid sinus and the skull base. ...
https://orl-konstantinidis.gr/en/chordoma.html
Chordoma in Orthopedic Surgery: Practice Essentials, Pathophysiology, EpidemiologyChordoma in Orthopedic Surgery: Practice Essentials, Pathophysiology, Epidemiology
Background and etiopathology Chordoma is a relatively rare malignant midline tumor arising in the axial skeleton, primarily at ... Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. Am J Clin Pathol. 1994 Jan. 101 (1):36- ... encoded search term (Chordoma in Orthopedic Surgery) and Chordoma in Orthopedic Surgery What to Read Next on Medscape ... Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. Am J Clin Pathol. 1995 Mar. 103 (3):271-9. [ ...
http://emedicine.staging.medscape.com/article/1263740-overview
Spinal Chordomas | Skull Base Program | Barrow Neurological InstituteSpinal Chordomas | Skull Base Program | Barrow Neurological Institute
Spinal chordomas are a type of cancer at the base of the skull or along the spinal column. Learn about diagnosis, symptoms and ... Who gets spinal chordomas?. Chordomas of the skull base are more common in young people, while chordomas of the lower spine are ... A chordoma isa type of cancer that occurs at the base of the skull or along the spinal column. Chordomas are commonly treated ... Spinal Chordoma Treatment. Surgical removal is the optimal and standard treatment for spinal chordomas. Your doctor will try to ...
https://www.barrowneuro.org/condition/spinal-chordomas/
IMSEAR at SEARO: Cytologic diagnosis of chordoma by fine needle aspiration.
Verma K, Murthy L, Kapila K. Cytologic diagnosis of chordoma by fine needle aspiration. Indian Journal of Pathology & ...
https://imsear.searo.who.int/handle/123456789/72752
Board of Directors | Canadian Chordoma NetworkBoard of Directors | Canadian Chordoma Network
Ed is a pediatric emergency medicine physician in Alberta, Canada and a clival chordoma survivor. A former Chordoma Foundation ... Les is also helping to spearhead a major fundraising initiative on the part of Canadian families impacted by chordoma. He ... Canadian Chordoma Network - Toronto - Ontario. Steven Golick [email protected] , Tobi Liederman [email protected] ... Foundation and the Canadian Cancer Society to allow Canadian donors to submit tax-deductible gifts in support of chordoma ...
https://canadianchordomanetwork.ca/board-directors
Paediatric Chordoma Research - Drew Barker-Wright CharityPaediatric Chordoma Research - Drew Barker-Wright Charity
As chordoma is so rare it is important to identify all children with chordoma in the UK so that we can learn more about this ... Advances in chordoma research. A great deal has been learned about adult chordoma in the past 10 - 15 years. Much of this ... The generation of several chordoma cell lines has also been extremely useful to study chordomas. A cell line is a population of ... Whilst many of the findings about adult chordoma will be relevant to paediatric chordoma, there is still a lot that we dont ...
https://www.dbwcharity.org/paediatric-chordoma-research/
Lumbosacral chordoma: Prognostic factors and treatment<...Lumbosacral chordoma: Prognostic factors and treatment<...
Staging of chordomas has not been of much value, compared with other bone tumors, because for chordomas, grade is similar, ... Staging of chordomas has not been of much value, compared with other bone tumors, because for chordomas, grade is similar, ... Staging of chordomas has not been of much value, compared with other bone tumors, because for chordomas, grade is similar, ... Staging of chordomas has not been of much value, compared with other bone tumors, because for chordomas, grade is similar, ...
https://experts.umn.edu/en/publications/lumbosacral-chordoma-prognostic-factors-and-treatment
Recent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268 - 1st EditionRecent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268 - 1st Edition
5: Malignant tumors: Chordomas and chondrosarcomas. *6: Malignant tumors: Solitary fibrous tumor/hemangiopericytoma ...
https://www.elsevier.com/books/recent-advances-and-controversies-in-gamma-knife-nrgery/ganz/978-0-12-823564-5
Chordoma Low-Template Microarray Analysis<...Chordoma Low-Template Microarray Analysis<...
Chordoma Low-Template Microarray Analysis. Julia Feichtinger, Amin El-Heliebi, Thomas Kroneis, Karin Wagner, Bernadette Liegl- ... title = "Chordoma Low-Template Microarray Analysis",. author = "Julia Feichtinger and Amin El-Heliebi and Thomas Kroneis and ... Chordoma Low-Template Microarray Analysis. / Feichtinger, Julia; El-Heliebi, Amin; Kroneis, Thomas et al. ... Feichtinger, J, El-Heliebi, A, Kroneis, T, Wagner, K, Liegl-Atzwanger, B, Leithner, A, Thallinger, G & Rinner, B 2013, Chordoma ...
https://graz.pure.elsevier.com/en/publications/chordoma-low-template-microarray-analysis
Head of Clinical Research job with Chordoma Foundation | 7615394Head of Clinical Research job with Chordoma Foundation | 7615394
Head of Clinical Research job in Remote with Chordoma Foundation. Apply Today. ... ABOUT THE CHORDOMA FOUNDATION. The Chordoma Foundation is a nonprofit organization created by patients and families to be an ... Chordoma Foundation Location. Remote. Salary. Commensurate with experience. Closing date. Dec 17, 2022. View more ... The Chordoma Foundation offers a competitive salary and benefits package including:. *100% employer-sponsored health insurance ...
https://careercenter.asco.org/job/7615394/head-of-clinical-research/
Endoscope-assisted anterolateral approach for a craniovertebral junction chordoma. | Clin Neurol Neurosurg;228: 107706, 2023...Endoscope-assisted anterolateral approach for a craniovertebral junction chordoma. | Clin Neurol Neurosurg;228: 107706, 2023...
Chordomas of craniovertebral junction represent a challenging pathology for neurosurgeons, due to their deep location, ... We present the case of a 24 years old female with a craniovertebral junction chordoma with anterior and right lateral extension ... Endoscope-assisted anterolateral approach for a craniovertebral junction chordoma. Endoscope-assisted anterolateral approach ... The anterolateral approach is a valuable option for craniovertebral junction chordomas with lateral extension and the endoscope ...
https://pesquisa.bvsalud.org/brasil/resource/pt/mdl-37058771
the challenges of treating a chordoma: interview with Jean-Paul Wolinsky, MDthe challenges of treating a chordoma: interview with Jean-Paul Wolinsky, MD
You can listen to our 15-minute interview here: https://physicianpodcasts.nm.org/ #braintumor #neurosurgery #chordoma @ ... specializes in treating chordomas, a rare tumor that affects only 1 in 1 million people. Dr. Wolinsky is a Professor of ... Neurosurgeon Jean-Paul Wolinsky, MD, specializes in treating chordomas, a rare tumor that affects only 1 in 1 million people. ... the challenges of treating a chordoma: interview with Jean-Paul Wolinsky, MD. ...
https://www.andrewwilner.com/post/the-challenges-of-treating-a-chordoma-interviw-with-jean-paul-wolinsky-md
The management of clival chordomas: an Italian multicentric studyThe management of clival chordomas: an Italian multicentric study
... Cavallo, Luigi Maria;Mazzatenta, Diego;dAvella, Elena; ... METHODS Clival chordoma cases surgically treated between 1999 and 2018 at 10 Italian neurosurgical departments were included in ... In the last 2 decades, the endoscopic endonasal approach in the treatment of clival chordomas has evolved to be a viable ... OBJECTIVE In the last 2 decades, the endoscopic endonasal approach in the treatment of clival chordomas has evolved to be a ...
https://irinsubria.uninsubria.it/handle/11383/2103493
骨癌 - 医生与科室 - 妙佑医疗国际骨癌 - 医生与科室 - 妙佑医疗国际
Proton therapy, IMRT, Brachytherapy, Radiation therapy, Endometrial cancer, Chondrosarcoma, Osteosarcoma, Chordoma, Eye... ... Chordoma, Chondrosarcoma, Juvenile nasopharyngeal angiofibroma, Craniopharyngioma, Sinonasal melanoma, Skull base tumor, Nasal ...
https://www.mayoclinic.org/zh-hans/diseases-conditions/bone-cancer/doctors-departments/ddc-20350223?lastInitial=P&page=1
Proton therapy with a fixed beamline for skull-base chordomas and chondrosarcomas: outcomes and toxicity | Radiation Oncology |...Proton therapy with a fixed beamline for skull-base chordomas and chondrosarcomas: outcomes and toxicity | Radiation Oncology |...
Chordomas (CAs) and chondrosarcomas (CSAs) are rare tumours that are usually located near the base of the skull and very close ... even the difficult-to-treat subpopulation of patients with skull-base chordomas or chondrosarcomas requiring dose escalation. ... of outcomes in patients with skull-base chordomas or chondrosarcomas treated with a fixed horizontal pencil proton beam. ... Chordomas (CAs) and chondrosarcomas (CSAs) are rare tumours that are usually located near the base of the skull and very close ...
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-021-01961-9
Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasisTransformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis
Notochord cells can give rise to chordomas, a highly invasive bone cancer associated with late diagnosis. Understanding the ... By depleting inflammatory cells, we abrogated chordoma development and rescued the skeletal features of the vertebral column. ... supported parallels between chordomas, wound and inflammation. Cancerous notochordal cells interfere with differentiation of ... suggesting parallels between chordoma, wound, IVD degeneration and inflammation, highlighting inflammation as a promising ...
https://pubmed.ncbi.nlm.nih.gov/33579726/
Dr. Ralph Brasacchio, MD | Radiation Oncology in Canandaigua, NY | Healthline FindCareDr. Ralph Brasacchio, MD | Radiation Oncology in Canandaigua, NY | Healthline FindCare
Primary Cancerous Bone Tumors - Bone, Joint, and Muscle Disorders - MSD Manual Consumer VersionPrimary Cancerous Bone Tumors - Bone, Joint, and Muscle Disorders - MSD Manual Consumer Version
Chordomas Chordomas are rare and cancerous and tend to occur at the ends of the spinal column, usually in the middle of the ... A chordoma affecting the sacrum or tailbone causes nearly constant pain. A chordoma in the base of the skull can cause problems ... Chordomas affecting the sacrum or tailbone may be cured by surgical removal. Chordomas in the base of the skull usually cannot ... To help diagnose chordomas, doctors do magnetic resonance imaging Computed tomography (CT) and magnetic resonance imaging (MRI ...
https://www.msdmanuals.com/en-pt/home/bone,-joint,-and-muscle-disorders/bone-and-joint-tumors/primary-cancerous-bone-tumors
TumorTumorsChondrosarcomaSacral chordomaMalignantResectionCraniovertebral junction chordomaDiagnosisDistribution of chordomasSpineMetastatic chordomaSacrococcygeal chordomaClivalChondrosarcomasSacrumOccurNeoplasmVertebralArise from remnants of the notochordPatientsBrachyuryNotochordalSkullSurgicalSpinal columnPoorly differentiatedSoft tissueTherapeuticRare100,000PrognosisTypicallyClinicalImmunotherapySurgeryPosteriorRadiationTreatmentProtein
Tumor24
  • A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. (medlineplus.gov)
  • Chordoma: the nonsarcoma primary bone tumor. (medlineplus.gov)
  • The direct synergistic effect between IT and RT against chordoma was observed, evidenced by lowest tumor volume, highest cytotoxic T cells, and memory T cells. (cns.org)
  • We report a complication of single dose intent to treat SBRT for a sacral chordoma that should serve to remind oncologists that radiation therapy, like surgery, is not without serious potential complications and that surgical resection may still be the best option for patients whose tumor can be treated with en bloc resection. (fortunejournals.com)
  • Current literature clearly demonstrates that wide en bloc resection with negative surgical margins is the single most important predictor of tumor recurrence and long term survival [1, 2]. (fortunejournals.com)
  • Chordoma is a rare slow-growing malignant tumor that erodes the clivus, the sphenoid sinus and the skull base. (orl-konstantinidis.gr)
  • Some data suggest that female sex, tumor necrosis, and tumor volume of more than 70 mL are independent poor prognostic variables in skull-base chordomas. (medscape.com)
  • Neurological problems and pain are often the first symptoms associated with chordomas, but the size and location of the tumor dictate the presence and severity of symptoms. (barrowneuro.org)
  • For example, a chordoma occurring at the base of the skull might produce headaches of gradually increasing severity as the tumor grows, while a chordoma at the base of the spine might not produce any symptoms until the cancerous mass is large and forms a noticeable lump. (barrowneuro.org)
  • Definitive diagnosis of a spinal chordoma is dependent on biopsy and examination of the tumor tissue by a neuropathologist. (barrowneuro.org)
  • Chordoma is a very rare tumor that forms in bones of the spine. (cancer.gov)
  • A chordoma is a low-grade, slow-growing, but locally invasive and locally aggressive tumor. (medscape.com)
  • 2] Although a chordoma is usually a slow-growing tumor, it is locally aggressive and has a tendency to infiltrate into adjacent tissues and organs. (medscape.com)
  • Chordoma is a rare tumor that occurs along the axial spine in children and in adults, with an incidence of approximately 350 cases per year in the United States[6] and a reported annual worldwide incidence of 0.08 per 100,000 cases. (medscape.com)
  • Neurosurgeon Jean-Paul Wolinsky, MD, specializes in treating chordomas, a rare tumor that affects only 1 in 1 million people. (andrewwilner.com)
  • In the last 2 decades, the endoscopic endonasal approach in the treatment of clival chordomas has evolved to be a viable strategy to achieve maximal safe resection of this tumor. (uninsubria.it)
  • Patients with advanced chordoma, a type of sarcoma , have few therapeutic options and immunotherapies have largely been ineffective due in part to the absence of T cells that recognize tumor targets. (cancerresearch.org)
  • Herein we present a case of metastatic (CT) guided biopsy of soft tissue mass showed lobu- sacral chordoma that has shown response to erlotinib lated architecture composed of tumor cells having clear after having progressed on imatinib. (deepdyve.com)
  • Due to the slow growth of the tumor mass, pain is the most common presenting symptom for sacral chordomas (SC) [ 13 - 15 ], but patients may also experience neurologic symptoms when the lesion involves the nerve roots, characterized by changes in bowel and bladder function, incontinence, sexual and walking impairment. (e-neurospine.org)
  • Whenever feasible, surgical en bloc resection of the tumor, extended to surrounding normal tissues, is considered the optimal treatment option in the first instance [ 11 , 17 - 19 ]. (e-neurospine.org)
  • When a giant cell tumor occurs in the sacrum, it occurs in the Ala, which is different from chordomas which occur in the midline of the sacrum. (medium.com)
  • In the sacrum, you need to differentiate a Giant Cell Tumor from Chordoma. (medium.com)
  • Tumor maligno que se origina en los restos embrionarios de la notocorda. (bvsalud.org)
  • In the latest version of the guidelines released in November 2020, surgery is the main treatment for chondrosarcoma, chordoma, and giant cell tumor of bone, which can be combined with radiotherapy or targeted therapy. (bvsalud.org)
Tumors13
  • Chordomas comprise fewer than 1 percent of tumors affecting the brain and spinal cord. (medlineplus.gov)
  • Chordomas and chondrosarcoma constitute the majority of malignant sacral tumors in adulthood. (fortunejournals.com)
  • When possible, en bloc surgical resection has been the recommended treatment for these tumors. (fortunejournals.com)
  • Although this explains the observed distribution of chordomas (sphenoccipital and sacrococcygeal), it does not explain why the cell rests should transform into tumors. (medscape.com)
  • Children are more likely to have skull-base tumors, whereas spinal chordomas are more common in older individuals. (medscape.com)
  • Chordomas account for approximately 1-4% of all malignant bone tumors and 20% of primary tumors of the spinal column. (medscape.com)
  • It is thought that, for reasons not known at this time, remnant notochord cells persist in some people, and in some cases, these cells give rise to chordoma tumors. (barrowneuro.org)
  • Chordomas belong to the sarcoma family of tumors. (medscape.com)
  • Chordomas account for approximately 20% of primary spinal tumors and only 3% of all bone tumors. (medscape.com)
  • Staging of chordomas has not been of much value, compared with other bone tumors, because for chordomas, grade is similar, metastasis is infrequent at presentation, and the prognostic significance of size is uncertain. (umn.edu)
  • Chordomas are slow-growing tumors, with a high tendency to local relapse. (e-neurospine.org)
  • Chordomas are rare and locally aggressive tumors arising from remnants of notochord [ 1 , 2 ]. (e-neurospine.org)
  • transsphenoidal surgery , including extended approaches for suprasellar and clival tumors (e.g. meningiomas, craniopharyngiomas, chordomas). (uclahealth.org)
Chondrosarcoma2
  • With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
  • Chondroid describes chordomas that are difficult to distinguish from chondrosarcoma on histology. (medscape.com)
Sacral chordoma4
  • In this report we present a case of a gentleman with a sacral chordoma who was offered en bloc resection but elected to proceed with SBRT. (fortunejournals.com)
  • The patient is a 77-year-old male who five years ago had been treated for a sacral chordoma with SBRT presented to the ED with lumbosacral pain. (fortunejournals.com)
  • We report a case of metastatic sacral chordoma with symp- tomatic and radiological response to erlotinib post-progression on imatinib. (deepdyve.com)
  • Case presentation: A 48-year-old male with a sacral chordoma underwent partial sacrectomy followed by post- operative radiotherapy. (deepdyve.com)
Malignant2
  • Chordomas are rare, slow growing malignant tumours of the spinal axis originating from remnants of the notochord. (elsevier.com)
  • Chordoma is a clinically and histologically unique malignant neoplasm, and numerous diagnostic considerations must be excluded to establish the correct diagnosis. (medscape.com)
Resection6
  • Overall 5-year survival is approximately 50%, and treatment consists of en bloc surgical resection followed by high-dose conformal radiation therapy (RT) such as proton beam radiation. (medscape.com)
  • Surgical en bloc resection with negative margins is the only curative treatment for chordoma. (medscape.com)
  • To analyze the prognostic factors in patients with chordomas, the success of various treatments, the diagnostic value of open versus needle biopsy, the neurologic impairment after sacral nerve resection, and the clinical presentation and site of origin. (umn.edu)
  • Keywords: Chordoma, EGFR, Erlotinib Background adjuvant setting after a full or subtotal resection, and as Chordoma is a rare mesenchymal neoplasm which arises the primary treatment in unresectable disease. (deepdyve.com)
  • En bloc resection is related to the most favorable outcome in terms of survival but is frequently associated with permanent neurological deficits involving sphincters and sexual functions. (e-neurospine.org)
  • In the present article, we describe an innovative technique of en bloc resection followed by reconstruction of the sacral nerves with nerve grafts. (e-neurospine.org)
Craniovertebral junction chordoma2
  • Endoscope-assisted anterolateral approach for a craniovertebral junction chordoma. (bvsalud.org)
  • We present the case of a 24 years old female with a craniovertebral junction chordoma with anterior and right lateral extension. (bvsalud.org)
Diagnosis6
  • Histological and immunohistochemical findings led us to the diagnosis of classic chordoma. (elsevier.com)
  • Chordomas can affect individuals of any age, including young children, but are most often diagnosed in individuals between the ages of 40 and 75 years (average age at diagnosis, 55 y). (medscape.com)
  • IMSEAR at SEARO: Cytologic diagnosis of chordoma by fine needle aspiration. (who.int)
  • Verma K, Murthy L, Kapila K. Cytologic diagnosis of chordoma by fine needle aspiration. (who.int)
  • If your child has been diagnosed with paediatric chordoma and you would like to reach out to the team to join the UK based study and make sure they are aware of your diagnosis, please contact their coordinator at The Royal National Orthopaedic Hospital. (dbwcharity.org)
  • Notochord cells can give rise to chordomas, a highly invasive bone cancer associated with late diagnosis. (nih.gov)
Distribution of chordomas1
  • The location distribution of chordomas is 50% sacral, 35% skull base, and 15% vertebral bodies of the mobile spine (most commonly, the C2 vertebra, followed by the lumbar then the thoracic spine). (medscape.com)
Spine6
  • Approximately half of all chordomas occur at the base of the spine (sacrum), about one third occur in the base of the skull (occiput), and the rest occur in the cervical (neck), thoracic (upper back), or lumbar (lower back) vertebrae of the spine. (medlineplus.gov)
  • A chordoma anywhere along the spine may cause pain, weakness, or numbness in the back, arms, or legs. (medlineplus.gov)
  • Chordomas of the skull base are more common in young people, while chordomas of the lower spine are more common later in life. (barrowneuro.org)
  • However, chordomas can occur at any location on the spine or skull base at any age. (barrowneuro.org)
  • They occur exclusively in resistance of chordoma paved the way to different antitu spine, predominantly at sacrococcygeal and spheno- - occipital areas, at a median or paramedian location [4]. (deepdyve.com)
  • Management of locally recurrent chordoma of the mobile spine and sacrum: A systematic review. (bvsalud.org)
Metastatic chordoma1
  • Occasionally, a skin lesion is the first sign of a primitive or metastatic chordoma. (elsevier.com)
Sacrococcygeal chordoma3
  • Background: Sacrococcygeal chordoma presents a difficult diagnostic and therapeutic problem, with a high rate of local recurrence. (elsevier.com)
  • Methods: Fifty-two patients underwent surgical treatment for sacrococcygeal chordoma between 1980 and 2001. (elsevier.com)
  • Conclusions: A wide surgical margin is the most important predictor of survival and of local recurrence in patients with sacrococcygeal chordoma. (elsevier.com)
Clival4
  • Ed is a pediatric emergency medicine physician in Alberta, Canada and a clival chordoma survivor. (canadianchordomanetwork.ca)
  • Here, the authors present a multicentric national study, intending to analyze the evolution of this approach over a 20-year time frame and its contribution in the treatment of clival chordomas. (uninsubria.it)
  • METHODS Clival chordoma cases surgically treated between 1999 and 2018 at 10 Italian neurosurgical departments were included in this retrospective study. (uninsubria.it)
  • CONCLUSIONS Through multicentric data collection, this study encompasses the largest series in the literature of clival chordomas surgically treated through an EETA. (uninsubria.it)
Chondrosarcomas5
  • Typically, chordomas express the brachyury gene, whereas chondrosarcomas do not express this gene. (medscape.com)
  • This study presents an analysis (efficacy and toxicity) of outcomes in patients with skull-base chordomas or chondrosarcomas treated with a fixed horizontal pencil proton beam. (biomedcentral.com)
  • Chordomas (CAs) and chondrosarcomas (CSAs) are rare tumours that are usually located near the base of the skull and very close to the brain's most critical structures. (biomedcentral.com)
  • Treatment with a fixed proton beam shows promising disease control and an acceptable toxicity rate, even the difficult-to-treat subpopulation of patients with skull-base chordomas or chondrosarcomas requiring dose escalation. (biomedcentral.com)
  • Chordomas and chondrosarcomas are rare among malignancies and mainly affect the skull base, sacrum bones, and vertebral column (less). (biomedcentral.com)
Sacrum1
  • Vertebral body chordomas have a higher incidence of metastasis than do those arising in the clivus or sacrum. (medscape.com)
Occur4
  • Chordomas typically occur in adults between ages 40 and 70. (medlineplus.gov)
  • Other cases of chordoma are sporadic, which means they occur in people with no history of the condition in their family. (medlineplus.gov)
  • Chordomas are commonly treated by neurologists and neurosurgeons because they occur in and around the bony tissues surrounding the central nervous system. (barrowneuro.org)
  • Chordomas typically occur in adults between the ages of 40 and 70 and affect males twice as often as females [ 8 , 10 ]. (e-neurospine.org)
Neoplasm1
  • Raj, S. T. Arun 2020-12-12 00:00:00 Background: Chordoma is a rare, slow growing and locally aggressive mesenchymal neoplasm with uncommon distant metastases. (deepdyve.com)
Vertebral1
  • By depleting inflammatory cells, we abrogated chordoma development and rescued the skeletal features of the vertebral column. (nih.gov)
Arise from remnants of the notochord1
  • Chordomas get their name because they are thought to arise from remnants of the notochord. (barrowneuro.org)
Patients7
  • Thus, about 300 patients are diagnosed with chordoma each year in the United States and about 700 in all of Europe. (medscape.com)
  • Poorly differentiated chordomas are more common in young adult and pediatric patients, as are skull base chordomas, and show loss of the INI1 gene. (medscape.com)
  • Much of this knowledge has come from the study of tissue and blood samples from patients with chordoma. (dbwcharity.org)
  • A review of patients with chordoma from 1965 through 1996 found 23 cases (mean age of patients, 55 years). (umn.edu)
  • One solution to this challenge is to generate chordoma-killing T cells in the lab, grow these to large numbers, and infuse them into patients. (cancerresearch.org)
  • Radiotherapy also plays a key role in the management ated therapeutic agent in chordoma, based on the expres- of patients with localized chordoma, particularly in the sion of platelet-derived growth factor beta (PDGFβ) or its receptor (PDGFRβ) [7, 8]. (deepdyve.com)
  • The Chordoma Foundation is an international nonprofit organization working to improve the lives of chordoma patients by accelerating the development of effective treatments, and by helping patients to get the best care possible. (prlog.org)
Brachyury2
  • The specific mechanism by which excess brachyury protein contributes to the development of chordomas is unclear. (medlineplus.gov)
  • Brachyury seems to play a key role in the pathogenesis of chordoma, although the detailed mechanism remains to be elucidated. (medscape.com)
Notochordal1
  • From this bit of evidence, he correctly surmised the notochordal origin of chordomas. (medscape.com)
Skull2
  • A chordoma at the base of the skull (occipital chordoma) may lead to double vision (diplopia) and headaches. (medlineplus.gov)
  • A chordoma isa type of cancer that occurs at the base of the skull or along the spinal column. (barrowneuro.org)
Surgical2
  • Surgical removal is the optimal and standard treatment for spinal chordomas. (barrowneuro.org)
  • Surgical removal of your chordoma can be complicated by factors like large size or involvement of surrounding nerves, arteries and veins, bones, and organs. (barrowneuro.org)
Spinal column1
Poorly differentiated1
  • C l i n i c o p a t h o l o g i c characteristics of poorly differentiated chordoma. (bvsalud.org)
Soft tissue4
  • Chordomas grow slowly, gradually extending into the bone and soft tissue around them. (medlineplus.gov)
  • In rare cases these cells begin to grow and divide uncontrollably, invading the nearby bone and soft tissue and resulting in the development of a chordoma. (medlineplus.gov)
  • Chordomas present clinically as destructive bony masses with soft-tissue involvement. (medscape.com)
  • 4, 5] These are distinguished from ecchordosis physaliphora by their intraosseous location, and from chordoma by their well-demarcated radiographic appearance, bland histologic features, and lack of soft tissue extension. (medscape.com)
Therapeutic1
  • Conclusions: As seen in previously reported cases, erlotinib is a therapeutic option in advanced chordoma, even in imatinib refractory cases and thus warrants exploration of its therapeutic role in prospective clinical trials. (deepdyve.com)
Rare5
  • Chordomas are rare, occurring in approximately 1 per million individuals each year. (medlineplus.gov)
  • We demonstrated that this humanized mouse model could be a revolutionary platform to investigate IT against rare cancers such as chordomas, where murine equivalents are unavailable. (cns.org)
  • Spinal chordomas are rare. (barrowneuro.org)
  • Ecchordosis physaliphora is a reported finding in approximately 2% of autopsy examinations, whereas chordomas are quite rare. (medscape.com)
  • As chordoma is so rare it is important to identify all children with chordoma in the UK so that we can learn more about this disease. (dbwcharity.org)
100,0001
  • At any given time, fewer than one in 100,000 people are living with chordoma. (medscape.com)
Prognosis1
  • Different histologic subtypes of chordoma differ in their prognosis. (medscape.com)
Typically1
  • Chordomas typically affect those in the 40- to 60-year age group but have been reported in children and in the very elderly. (medscape.com)
Clinical1
  • We hope this will represent the first step towards the initiation of clinical trials of promising new drugs for paediatric chordoma. (dbwcharity.org)
Immunotherapy1
  • Thus, to scrutinize immunotherapy (IT) against chordomas, the development of a humanized mouse model of chordomas, where human thymus and CD34+ stem cells as well as human chordomas are co-transplanted to engraft human immune system into mice, is imperative. (cns.org)
Surgery1
  • Unfortunately, however, if your consent is not obtained prior to surgery it may mean that some important research into paediatric chordoma cannot be carried out. (dbwcharity.org)
Posterior1
  • The chordoma was excised through a posterior approach after dividing the proximal and distal sacral nerves using the established technique. (e-neurospine.org)
Radiation1
  • We aimed to develop this model and investigate synergistic effect between IT and radiation therapy (RT) against chordomas using this model. (cns.org)
Treatment2
  • Currently, no medical treatment has been approved for treatment of chordoma. (medscape.com)
  • Treatment options, cure rates and research for paediatric chordoma fall well beneath other childhood cancers. (dbwcharity.org)
Protein2
  • Nakamura Y, Becker LE, Marks A. S100 protein in human chordoma and human and rabbit notochord. (medscape.com)
  • Dr. Yee has developed a strategy to identify these immunogenic targets by directly examining the protein fragments presented on the surface of chordoma cells. (cancerresearch.org)
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