Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Legislation, Food: Laws and regulations concerned with industrial processing and marketing of foods.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Job Application: Process of applying for employment. It includes written application for employment or personal appearance.Chordoma: A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)Skull Base: The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.Skull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Neuronavigation: Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.Chondrosarcoma, Mesenchymal: A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)Skull Neoplasms: Neoplasms of the bony part of the skull.Cadaver: A dead body, usually a human body.Skull Fractures: Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).Misonidazole: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.PaintingsRadiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Chromosome Painting: A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Gamma Rays: Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.ThiosemicarbazonesMassachusettsHospitals, General: Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients.BostonOlecranon Process: A prominent projection of the ulna that that articulates with the humerus and forms the outer protuberance of the ELBOW JOINT.Sacrum: Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.Spinal NeoplasmsCoccyx: The last bone in the VERTEBRAL COLUMN in tailless primates considered to be a vestigial tail-bone consisting of three to five fused VERTEBRAE.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Gastrointestinal Stromal Tumors: All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).Benzamides: BENZOIC ACID amides.PiperazinesPyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Proto-Oncogene Proteins c-kit: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Management Quality Circles: Participation of employees with management as a labor-management team, in decisions pertaining to the operational activities of the organization or industry.Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Patient Care Team: Care of patients by a multidisciplinary team usually organized under the leadership of a physician; each member of the team has specific responsibilities and the whole team contributes to the care of the patient.Clinical Trials, Phase I as Topic: Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.TexasAnger: A strong emotional feeling of displeasure aroused by being interfered with, injured or threatened.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Cancer Care Facilities: Institutions specializing in the care of cancer patients.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Spine: The spinal or vertebral column.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Spinal Cord: A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Jewelry: Objects of precious metal usually containing gems and worn to enhance personal appearance. Health concerns include possible contamination from lead content or bacteria.Frostbite: Damage to tissues as the result of low environmental temperatures.OsteomyelitisRadionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Dental Prosthesis: An artificial replacement for one or more natural teeth or part of a tooth, or associated structures, ranging from a portion of a tooth to a complete denture. The dental prosthesis is used for cosmetic or functional reasons, or both. DENTURES and specific types of dentures are also available. (From Boucher's Clinical Dental Terminology, 4th ed, p244 & Jablonski, Dictionary of Dentistry, 1992, p643)

Recurrence of clival chordoma along the surgical pathway. (1/174)

Chordomas are locally aggressive malignant tumors of notochordal origin whose metastatic potential is increasingly recognized. Surgical pathway recurrence has been noted only rarely in the literature. We present three patients with clival chordomas whose sole or initial recurrence was along the pathway of prior surgical access. A characteristic mass found along the pathway of prior surgical access for resection of a chordoma should suggest recurrent chordoma.  (+info)

Sacral chordoma--a case report. (2/174)

Chordoma, a rare malignant tumour of early adulthood, rarely presents in children. We report such a case of rare malignant tumour which was diagnosed in the first decade of life.  (+info)

Isolated cardiac metastasis from sacral chordoma. (3/174)

A 64-year-old woman presented with right heart failure caused by a cardiac tumor centered in the free wall of the right ventricle, accompanied by pericardial effusion. A match between the biopsy specimen and tissue removed 4 years earlier resulted in the diagnosis of a cardiac metastasis from a chordoma. Immunohistochemical staining was also useful in establishing the diagnosis. To alleviate the right ventricular outflow obstruction, a palliative operation was planned, resecting the tumor and performing a right ventriculoplasty, which was cancelled due to the extent of infiltration of the tumor, and instead a right atrium to pulmonary artery shunt was attempted using a vascular prosthesis, only to fail due to an inability to maintain blood flow through the prosthesis. Presently there are no definitive treatment options available, and some palliative chemotherapy is being performed. Single cardiac metastases from a chordoma are extremely rare.  (+info)

Chordoid glioma: a neoplasm unique to the hypothalamus and anterior third ventricle. (4/174)

BACKGROUND AND PURPOSE: Chordoid glioma is a new clinicopathologic entity that occurs in the region of the hypothalamus/anterior third ventricle. The aims of this study were to describe the characteristic radiographic features of chordoid glioma, identify specific imaging features that may enable differentiation of chordoid glioma from other suprasellar tumors, and increase neuroradiologists' awareness of this newly described tumor, facilitating prospective diagnosis. METHODS: CT scans and/or MR images of six patients with chordoid glioma were reviewed retrospectively to determine whether any characteristic radiographic features would emerge. Reports of the clinical presentation, pathologic findings, and radiographic findings of another six patients were reviewed and included, for a total patient population of 12 (mean age +/- SD, 46 +/- 13 years). RESULTS: Imaging features were strikingly similar for all tumors. In each case, the mass was ovoid, was well circumscribed, was located in the region of the hypothalamus/anterior third ventricle, and enhanced uniformly and intensely. Tumors were hyperdense to gray matter on CT scans and were isointense on T1-weighted MR images and slightly hyperintense on long-TR MR images. In two patients, vasogenic edema extended into the optic tracts, and in three, there was hydrocephalus. CONCLUSION: Chordoid glioma is a recently described unique histopathologic entity that has been added to the World Health Organization glioma classification scheme and must be included in the differential diagnosis of a suprasellar mass. Distinctive imaging features are its location, ovoid shape, hyperdensity on CT scans, and uniform intense contrast enhancement.  (+info)

Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development. (5/174)

Chordoma is the fourth most common malignant primary neoplasm of the skeleton and almost the only one showing a real epithelial phenotype. Besides classic chordoma, so-called chondroid chordoma was described as a specific entity showing cartilage-like tissue within chordomatoid structures. However, since its first description, strongly conflicting results have been reported about the existence of chondroid chordoma and several studies suggested chondroid chordomas being in fact low-grade conventional chondrosarcomas. In the present study, we used cytoprotein expression profiling and molecular in situ localization techniques of marker gene products indicative of developmental phenotypes of chondrocytes to elucidate origin and biology of chondroid chordoma. We were able to demonstrate the chondrogenic potential of chordomas irrespectively of the appearance of overt cartilage formation by identifying the multifocal expression of type II collagen, the main marker of chondrocytic differentiation. Additionally, the cartilage-typical large aggregating proteoglycan aggrecan was present throughout all chordomas and, thus, a very characteristic gene product and marker of these neoplasms. Biochemical matrix composition and cell differentiation pattern analysis showed a high resemblance of classic chordomas and in chordoid areas of chondroid chordomas to the fetal chorda dorsalis, whereas chondroid areas of chondroid chordomas showed features similar to adult nucleus pulposus. This demonstrates on the cell function level the chondrocytic differentiation potential of neoplastic chordoid cells as a characteristic facet of chordomas, mimicking fetal vertebral development, ie, the transition of the chorda dorsalis to the nucleus pulposus. Our study firmly establishes a focal real chondrocytic phenotype of neoplastic cells in chordomas. Chondroid chordoma is neither a low-grade chondrosarcoma nor a misnomer as discussed previously.  (+info)

Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (6/174)

Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. We performed a genomewide analysis for linkage in a family with 10 individuals affected by chordoma. The maximum two-point LOD score based on only the affected individuals was 2.21, at recombination fraction 0, at marker D7S2195 on chromosome 7q. Combined analysis of additional members of this family (11 affected individuals) and of two unrelated families (one with 2 affected individuals and the other with 3 affected individuals), with 20 markers on 7q, showed a maximum two-point LOD score of 4.05 at marker D7S500. Multipoint analysis based on only the affected individuals gave a maximum LOD score of 4.78, with an approximate 2-LOD support interval from marker D7S512 to marker D7S684. Haplotype analysis of the three families showed a minimal disease-gene region from D7S512 to D7S684, a distance of 11.1 cM and approximately 7.1 Mb. No loss of heterozygosity was found at markers D7S1804, D7S1824, and D7S2195 in four tumor samples from affected family members. These results map a locus for familial chordoma to 7q33. Further analysis of this region, to identify this gene, is ongoing.  (+info)

Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. (7/174)

BACKGROUND AND PURPOSE: This study was undertaken to analyze enhancement patterns of the dura around sellar tumors and to compare the results with tumor invasion or compression of the cavernous sinuses. Postoperative enhancement patterns on MR images were compared with preoperative findings. METHODS: Contrast-enhanced coronal and sagittal MR images were examined prospectively in 96 patients with sellar tumors (65 macroadenomas, 15 microadenomas, 14 Rathke cleft cysts, and two chordomas at the sella). All patients underwent surgical treatment, and pre- and postsurgical features on MR images were compared. RESULTS: Presurgical MR images showed dural enhancement in 36.5% of the patients: asymmetric tentorial enhancement in 24 patients, symmetric tentorial enhancement in seven, and sphenoidal ridge or clivus enhancement in four. Asymmetric tentorial enhancement disappeared after surgical decompression in seven patients. For evaluation of cavernous sinus invasion ipsilateral to the enhancement, sensitivity and specificity of the asymmetric tentorial enhancement sign were 81.3% and 86.3%, respectively. Sensitivity and specificity of the sign were 42.9% and 93.6% for cavernous sinus involvement, including compression and invasion. CONCLUSION: Asymmetric tentorial enhancement is a useful sign in the diagnosis of invasion or severe compression of the cavernous sinus by sellar tumor. The sign may represent venous congestion or collateral flow in the tentorium due to obstructed flow in the medial portion of the cavernous sinus.  (+info)

Vertebral reconstruction with cortical allograft: long-term evaluation. (8/174)

Reconstruction of large anterior vertebral column defects is indicated in a number of pathological conditions including tumor, infection, trauma and post-traumatic deformity. Several substitutes and techniques are available for the functional restoration of the vertebral column. Vascularized bone transfers, autografts, allografts or xenografts have been used, as well as metal or ceramic implants. All of these bear potential advantages and drawbacks in terms of associated morbidity of graft harvesting, disease transmission, mechanical failure, implant incorporation and overall long-term clinical outcome. In the present paper we report our experience with the use of freeze-dried, gamma-irradiated, cortical allograft for the reconstruction of large, anterior segmental defects of the spine, involving at least one vertebral body with its two adjacent discs. Cortical allografts were used in 67 cases operated for a variety of conditions. No case of disease transmission, infection or long-term mechanical graft failure occurred in our entire series, with a mean follow-up of 31 months. Fusion and mechanical stability was reliably obtained. Specific advantages include the absence of donor site morbidity, the possibilities for exact trimming to the size of the defect, superior mechanical strength as compared to available autograft, and reliable fusion with the host bone with partial bone remodeling, preventing fatigue failure. We conclude that freeze-dried, irradiated cortical allografts are safe and effective for anterior reconstruction of the spine.  (+info)

*Chordoma

Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the ... Chordoma Foundation - organization working to improve the lives of chordoma patients and lead the search for a cure Images of ... Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled. The proximity of chordomas to ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ...

*Cancer cell

Hirsch, Edwin F.; Ingals, Mary (1923). "Sacrococcygeal chordoma". JAMA: The Journal of the American Medical Association. 80 (19 ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...

*Rudolf Virchow

Virchow was the first to precisely describe and give names of diseases such as leukemia, chordoma, ochronosis, embolism, and ... Hirsch, Edwin F.; Ingals, Mary (1923). "Sacrococcygeal chordoma". JAMA: The Journal of the American Medical Association. 80 (19 ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...

*Sacrum

"Understanding Chordoma - Chordoma Foundation". www.chordomafoundation.org. Retrieved 2017-04-07. Wedel, F.P. "D.O" (PDF). A.T. ... The sacrum is one of the main sites for the development of the sarcomas known as chordomas that are derived from the remnants ...

*GTPBP3

"Chordoma-natural history, treatment and prognosis. The Florence Radiotherapy Department experience (1956-1990) and a critical ...

*Clivus (anatomy)

Clivus is also the site for chordoma (a rare malignant tumour.) The clivus is an important landmark for checking for anatomical ...

*Brachyury

The chromosomal region on 6q27 containing the brachyury gene was gained in 6 of 21 chordomas (29%), and none of the 21 ... Homeobox protein NANOG POU5F1 SOX2 MIXL1 GSC EOMES Transcription factors Gene regulatory network Bioinformatics Chordoma GRCh38 ... Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma. ... is a novel biomarker for chordomas". J. Pathol. 209 (2): 157-65. doi:10.1002/path.1969. PMID 16538613. Du R, Wu S, Lv H, et al ...

*Glial fibrillary acidic protein

Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". ...

*Proton therapy

1999). ": Proton radiation therapy for chordomas and chondrosarcomas of the skull base". J. Neurosurg. 91: 432-439. doi:10.3171 ... These include, among others, uveal melanoma (ocular tumors), skull base and paraspinal tumors (chondrosarcoma and chordoma), ...

*Houman Younessi

Younessi had survived four bouts of cancer since an initial diagnosis of malignant chordoma in 2009. "EWP: Catalog & Student ...

*Theodore H. Schwartz

PMID 18580797 Fraser JF, Nyquist GG, Moore N., Anand VK, Schwartz TH; Endoscopic endonasal transclival resection of chordomas: ...

*Neurosurgery

Techniques such as endoscopic endonasal surgery are used in pituitary tumors, craniopharyngiomas, chordomas, and the repair of ...

*Endoscopic endonasal surgery

This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical ... and clival chordomas (CHO). They looked at gross total resection and cerebrospinal fluid (CSF) leaks, neurological death, post- ...

*Cary Tennis

Tennis announced in his column of November 19, 2009, that he has been diagnosed with a chordoma, a rare malignant tumor that ...

*List of diseases (C)

... humero-metacarpal type Chordoma Chorea acanthocytosis Chorea familial benign Chorea minor Chorea Choreoacanthocytosis ...

*List of MeSH codes (C04)

... chordoma MeSH C04.557.465.280 --- dermoid cyst MeSH C04.557.465.330 --- germinoma MeSH C04.557.465.330.300 --- dysgerminoma ...

*Chromosome 6 (human)

... linked to Hepatocellular carcinoma and Chordoma (6q27) TAAR1: trace amine associated receptor 1 (6q23.1) TAAR2: trace amine ... DQB1 X-linked sideroblastic anemia Epilepsy Guillain Barre Syndrome Chordoma Hepatocellular carcinoma G-banding ideograms of ...

*Nasopharyngeal angiofibroma

... rhabdomyosarcoma Chordoma Nasopharyngeal cyst Pyogenic granuloma Treatment for Nasopharyngeal angiofibroma (JNA) is primarily ...

*Cancer syndrome

... familial chordoma, Cowden syndrome, dysplastic nevus syndrome with familial melanoma, familial adenomatous polyposis, ...

*International Classification of Diseases for Oncology

M9365/3 Askin Tumor M9370/3 Chordoma, NOS M9371/3 Chondroid chordoma M9372/3 Dedifferentiated chorcoma M9373/0 Parachordoma ...

*Craig Heyward

... reportedly a chordoma, at the base of his skull that was pressing on the optic nerve. After it was partially removed in a 12- ...

*Index of oncology articles

... chordoma - chorioallantoic membrane - choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic leukemia - chronic ...

*MUC1

Carcinoid tumor Chordoma Choriocarcinoma Desmoplastic small round cell tumor (DSRCT) Epithelioid sarcoma Follicular dendritic ...

*List of cutaneous conditions

Chondroid lipoma Chordoma Classic Kaposi sarcoma Collagenous fibroma (desmoplastic fibroblastoma) Composite ...

*Bone Cancer Research Trust

In addition, information on other primary bone cancers such as chondrosarcoma, chordoma, spindle cell sarcomas, angiosarcoma ...
The primary treatment for a skull base chordoma is surgery to remove as much of the tumor as possible. This is often an aggressive procedure that can lead to some side effects. But it offers the best chance for long-term survival. You and your healthcare team should weigh the risks and benefits of the procedure before the surgery. Once the surgery is done, an aggressive course of radiation therapy is used to kill the nearby tumor cells. Proton beam radiation is often used. It can focus on the needed area without exposing any critical organs and structures around it to radiation. Proton beam radiation offers the advantage of increasing the tumor dose while minimizing the dose to the nearby normal tissue. Other forms of radiation are sometimes used as well. Chemotherapy typically doesnt work well in treating a skull base chordoma. Currently, no medicines are approved for treating chordomas. But some have shown effectiveness in clinical trials. ...
The primary treatment for chordoma is the complete surgical removal of the tumor. To ensure the best outcome and prevent the spread of chordoma , the surgeon(s) must remove the chordoma and a margin of normal tissue surrounding it. The result of the first surgery is critical in determining the patients prognosis (outcome) It is vital that an experienced, expert team of surgeons perform the initial operative procedure. Skull based chordoma are generally removed through minimally invasive surgery by highly trained, skilled surgeons. Patients with chordoma at the base of the skull following this procedure usually require a brief hospital stay.. Chordomas that occur in the cervical, thoracic, lumbar or sacral spine have a larger area to grow requiring a more extensive operative procedure to remove them.. At the Harris Chordoma Center the surgeons perform the operative procedure in one or two stages depending on the size and location of the tumor. The surgeons are acutely aware of the risks in ...
Chordoma is an uncommon (400 case/year in the U.S.) and potentially fatal bone tumor derived from remnants of embryonic notochord. It occurs primarily in the axial skeleton and has a mean age at diagnosis of 55 years, with a range from early childhood to over 70 years. This tumor usually presents at an advanced stage and the associated mortality is high due to local destruction and distant metastases. Chordoma is rare in African-Americans and is typically sporadic; there are few reports of these tumors arising congenitally or within members of the same family.. Recently, we have identified and studied one large family in which 10 relatives in three generations have chordoma; the inheritance pattern suggests transmission of a mutation in an autosomal dominant gene. Using information from this family, we have tentatively napped this gene to the long arm of chromosome 7. To confirm this finding, and to fine map and clone the gene, we need to study additional chordoma families. In an effort to ...
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the location of the tumors (along the neuraxis), the similar immunohistochemical staining patterns, and the demonstration that notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the remainder of the notochord regresses during fetal life. There are three histological variants of chordoma: classical (or "conventional"), chondroid and dedifferentiated. The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. The cells have small round nuclei and abundant vacuolated cytoplasm, sometimes described as physaliferous (having bubbles or vacuoles). Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the skull base and anywhere along the spine. The two most common locations are cranially at the clivus ...
Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine-needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66-year-old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology specimen and of the Papanicolaou-stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led ...
What exactly was discovered? What is a SNP? Why is this discovery significant? What does this discovery mean for chordoma patients? Are family members of chordoma patients at risk? How does this discovery effect the development of new treatments? Is it now possible to predict who will get chordoma? How can I find out if…
Introduction: Chordoma is a relatively rare tumor originating from the embryonic remnants of the notochord. This is an aggressive, slow growing and invasive tumor. It occurs mostly at the two ends of neuroaxis which is more frequent in the sacrococcygeal region. Chordoma in vertebral column is very rare. This tumor is extradural in origin and compresses neural tissues and makes the patient symptomatic. This tumor found extremely rare in the spinal region as an intradural tumor.. The present study reports a rare case of intradural chordoma tumor as well as its clinical manifestations and treatment options. Case presentation: The patient was a 50-year-old female presented with 9 months history of progressively worsening neck pain, cervical spine chordoma resembling neurinoma and right arm numbness. Physical examination showed no weakness in her limbs, but she had upward plantar reflex and mild hyperreflexia. In a magnetic resonance imaging (MRI) scan of the cervical spine there was an ill-defined ...
Standard therapies for chordoma are limited. A clinical trial may provide an opportunity for chordoma patients to receive a new, experimental therapy.
Skull base chordomas (SBC) are characterized by persistent progression. Conventional radiation following resection increases 5- and 10-year local control (LC) to 36 and 23 %, respectively. Patients tr
TY - JOUR. T1 - Chordoma dedifferentiation after proton beam therapy. T2 - a case report and review of the literature. AU - Frankl, Joseph. AU - Grotepas, Cassi. AU - Stea, Baldassarre. AU - Lemole, Gerald M. AU - Chiu, Alexander G. AU - Khan, Rihan. PY - 2016/10/12. Y1 - 2016/10/12. N2 - Background: Chordoma is a rare invasive bone tumor that may occur anywhere along the neuraxis. A total of three primary histological varieties have been identified: conventional, chondroid, and dedifferentiated. Case presentation: We report a case of an 8-year-old white girl who presented with conventional chordoma, was treated with surgical resection and mixed proton and photon beam therapy, and had a recurrence in the resection cavity 2.5 years later with dedifferentiated morphology. The recurrent tumor did not express brachyury, a recently identified protein specific to tissue of notochordal origin. Conclusions: The short time period between radiation therapy and dedifferentiation, low dose of photons, and ...
Of the 3 parameters studied, Vp was the most significant measure of tumor response. Differences in Vp mean and Vp maximum values pre- and posttreatment were significant. On average, Vp max values were approximately 1.6 times greater before treatment, which is concordant with previous work demonstrating the significantly higher vascularization of chordoma in comparison with that of adjacent normal tissues.17 Chordoma has been shown to express elevated vascular endothelial growth factor and matrix metalloproteinase-9, which may work in concert to increase angiogenesis and invasiveness and promote recurrence of chordoma and other bone cancers.18⇓-20. Ktrans was also a positive indicator of tumor response to therapy. A measure of vascular permeability, Ktrans represents the rate at which blood is transferred from the vascular compartment to the extravascular extracellular space. Therefore, unlike Vp, Ktrans is a marker of tumor leakiness rather than actual tumor vascularity. On receiving RT, ...
Dr. Bensinger responded: Chordoma diplopia. Chordomas are rare, malignant tumors arising in the spine but which can spread elsewhere. Most are large when first discovered and if located at the base of the skull can affect the nerves to the |a href="/topics/eye" track_data="{
Chordomas are rare tumors that arise from remmants of the embryogenic notochord. There are three major groups: 1) Cranial or sphenooccipital, 2) Vertabral, 3) The sacrococcygeal. As chordomas, arising at the base of the skull, grow, they may extend toward the nasopharynx. Chordomas comprise 0.2 percent of nasopharyngeal tumors They are more common in men. They are slow growing and locally invasive. The prognosis is poor. Death is usually due to local recurrence and intracranial extension. They are usually treated surgically. Radiotherapy and chemotherapy have been of little value. A case of cervical chordoma, in a woman, extended toward the nosphorynx is presented and the literature about the tumor is reviewed. ...
Chordoma is a rare slow-growing neoplasm that arises from primitive notochordal remnants with a high rate of recurrence. It can occur anywhere within ..
OBJECTIVE: Even though carbon ions treatment (CIRT) of sacral chordoma (SC) substantially reduces tumor mass, tumor remnants are observed in most
This case demonstrates fairly characteristic imaging features of a clival chordoma which was subsequently histologically confirmed.
Acta Neurochir (2017) 159:1835-1845. Chordoma is a rare bony malignancy known to have a high rate of local recurrence after surgery. The best treatment paradigm is still being evaluated. We report our experience and review the literature. We emphasize on the difference between endoscopic and open craniotomy in regard to the anatomical compartment harboring the tumor, the limitations of the approaches and the rate of surgical resection.. Method: We retrospectively collected all patients with skullbase chordomas operated on between 2004 and 2014. Detailed radiological description of the compartments being occupied by the tumor and the degree of surgical resection is discussed.. Results: Eighteen patients were operated on in our facility for skull-base chordoma. Seventeen endoscopic surgeries were done in 15 patients, and 7 craniotomies were done in 5 patients. The mean age was 48.9 years (±19.8 years). When reviewing the anatomical compartments, we found that the most common were the upper clivus ...
Conclusion: This case involved an extraosseous, intradural, four-level subaxial cervical chordoma that demonstrated significant extraspinal extension into the anterior soft tissues of the neck. PMID: 29142772 [PubMed]...
Chordomas are lobulated and apparently capsulated tumours which arise from notochord and derive from ectoderm. Mainly seen in the sacrococygeal region, they may arise from the spheno-occipital region and protrude into the nasopharynx. While plain X-rays may show tumour with destruction of the clivus, CT-scan and MRI are essential assessment tools in delineating the gross margins of a chordoma [7]. Morphologically they can be confused with chondrosarcomas but they are characterised by bubble cells (physaliferous cells) with strands of spindle-shaped cells [8]. Immunohistochemistry is of diagnostic value and the tumour is stained positive to S-100, vimentin, epithelial membrane antigen and cytokeratin antibodies [5].. While radical surgical resection is the treatment of choice, this is rarely possible due to intracranial extension. There have been reports of using an endoscopic approach but in cases with extensive dural invasion, inferior clivus-centred tumours and large tumours extended to the ...
Diagnostics of chordoma of the skull base (costs for program #210797) ✔ University Hospital Frankfurt ✔ Department of Neurosurgery ✔ BookingHealth.com
Surgical resection of chordoma of the sacrum (costs for program #204893) ✔ University Hospital Münster ✔ Department of General and Tumor Orthopedics ✔ BookingHealth.com
HOLLYWOOD, FL-New guidelines that offer treatment algorithms for two relatively rare cancers-chordoma and giant cell tumors of the bone-were presented here at the National Comprehensive Cancer Network Annual Conference.. "The important thing to remember about chordoma is that if you suspect a patients has this bone cancer, you must refer the patient to a center of excellence, because even performing a biopsy can compromise the patients survival," said J. Sybil Biermann, MD, Professor and Medical Director of the Sarcoma Program at the University of Michigan Comprehensive Cancer Center and Chair of NCCNs Bone Cancer Guideline Writing Committee.. Although those usually benign tumors are generally considered to be in the realm of orthopedic surgeons, the committee decided to include them in the guidelines because there is still a small (about 2%) chance that the tumors can become malignant, she explained.. "Bone cancer is not very common-there are only about 2,500 cases a year in the United ...
Weʼre raising money to SAVE DREW BARKER - WRIGHT AS HE BATTLES WITH A RARE AND AGGRESSIVE CHORDOMA TUMOUR/CANCER. A NEW DIAGNOSIS, A NEW HOPE!! . Support this JustGiving Crowdfunding Page.
Specific mutations in PI3 kinase signaling genes have been discovered in chordoma, a rare bone cancer with the help of genomic sequencing.
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Chordoma
Objective: In most cases, spinal chordomas are sacrally located neoplasms arising from rests of notochordal tissue; sacrectomy with consecutive severe deficits is mostly advocated. We analyzed a pilot series with combined treatment by microsurgery and spinal robotic radiosurgery. The benefit of pre- and postoperative PET/CT-imaging and intraoperative CT-imaging (iCT) in combination with neuronavigation was evaluated.. Methods: Five patients (4 sacral, one cervical chordoma; diseased since 52 38 mo) were operated ten times since 1/07. No patient had severe neurological deficits. ICT was performed to control resection, to exclude lesions of adjacent structures and, in 2 patients, to generate images for navigation. In 4 patients remnant tumor with high operative risk was treated by spinal robotic radiosurgery for altogether 13 times (CyberKnife, Accuray; USA). In 3 patients FDG PET/CT was performed.. Results: Four patients are stable up to now without new deficits; one patient (tumor since 3/06, ...
Providence Health & Services, Southern California, provides the South Bay, Westside and San Fernando Valley a full spectrum of care that includes leading-edge diagnostics and treatment, outpatient health centers, the well-regarded Providence Medical Institute, numerous outreach programs and clinics, hospice and home care and Providence High School, a Blue Ribbon college-preparatory campus.. Read more. ...
Purpose: We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials: This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (relative biological effectiveness [RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose-volume parameters associated with radiation necrosis. Results: Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who ...
Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. Their ages ranged from 17 to 72 years (median 44 years). The most common presenting symptom was diplopia (26 patients, 93%). In two patients, SRS was the sole treatment. Twenty-six patients underwent between one and five additional surgical procedures. Two underwent an initial trans-sphenoidal biopsy. The average tumor volume was 9.8 cm3. The median dose to the tumor margin was 16 Gy. ...
Harsh, G.; Ojemann, R.; Varvares, M.; Swearingen, B.; Cheney, M.; Joseph, M., 2006: Pedicled rhinotomy for clival chordomas invaginating the brainstem
The tumour is slow growing and symptoms are often present for some time prior to diagnosis. Symptoms relate to the site; sacral tumours present with pain and sacral neuropathy; clival tumours with headache and cranial neuropathies (usually ocular), and spine tumours with pain and neuropathy.. ...
The anatomic junction of the neural and facial viscerocranium is termed the skull base (). This area is critically important because it supports the brain and allows all the neurovascular structures to either enter or exit the skull.Neoplasms may ori
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the Middle East Respiratory Syndrome, Severe Acute Respiratory Syndrome, and 2019-nCov. Coronaviruses can spread from animals to humans. Symptoms include fever, cough, shortness of breath, and breathing difficulties. In more severe cases, it can lead to death. Here is the latest research on coronaviruses. ...
Stacchiotti S., Gronchi A., Fossati P., Akiyama T., Alapetite C., Baumann M., Blay J.Y., Bolle S., Boriani S., Bruzzi P., Capanna R., Caraceni A., Casadei R., Colia V., Debus J., Delaney T., Desai A., Dileo P., Dijkstra S., Doglietto F., Flanagan A., Froelich S., Gardner P.A., Gelderblom H., Gokaslan Z.L., Haas R., Heery C., Hindi N., Hohenberger P., Hornicek F., Imai R., Jeys L., Jones R.L., Kasper B., Kawai A., Krengli M., Leithner A., Logowska I., Martin Broto J., Mazzatenta D., Morosi C., Nicolai P., Norum O.J., Patel S., Penel N., Picci P., Pilotti S., Radaelli S., Ricchini F., Rutkowski P., Scheipl S., Sen C., Tamborini E., Thornton K.A., Timmermann B., Torri V., Tunn P.U., Uhl M., Yamada Y., Weber D.C., Vanel D., Varga P.P., Vleggeert-Lankamp C.L.A., Casali P.G., Sommer J.: Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group. Ann. Oncol., 28:1230-1242, 2017. ...
Hank Lech's battle with chrodoma left him feeling angry, but over time he learned how to cope with his emotions and heal spiritually.
Pre-operative imaging of different skull base pathologies. The first case (A-C) is a 30-year-old male with a clival chordoma. The second case is a 36-year-old
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
Sartori, Giuseppe and Scarpazza, Cristina and Codognotto, Sara and Pietrini, Pietro An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. Journal of Neurology, 263 (7). pp. 1454-1455. ISSN 0340-5354 (2016) ...
Cancer that appears in the bone in the form of tumors is considered bone cancer or bone sarcoma. The most common form of bone cancer is Osteosarcoma which often appear in the knees, upper legs, and upper arms. Other forms of bone sarcoma include Chondrosarcoma which affects the cartilage in pelvis, upper legs, and shoulders; Chordoma which affects from base of the skull, all along the spine; and Ewings Sarcoma which affects the bone marrow and bones.
Malignant spinal tumors, categorized into primary and metastatic ones, are one of the most serious diseases due to their high morbidity and mortality rates. Common primary spinal tumors include chordoma, chondrosarcoma, osteosarcoma, Ewing’s sarcoma, and multiple myeloma. Spinal malignancies are not only locally invasive and destructive to adjacent structures, such as bone, neural, and vascular structures, but also disruptive to distant organs (e.g., lung). Current treatments for spinal malignancies, including wide resection, radiotherapy, and chemotherapy, have made significant progress like improving patients’ quality of life. Among them, chemotherapy plays an important role, but its potential for clinical application is limited by severe side effects and drug resistance. To ameliorate the current situation, various polymer nanoparticles have been developed as promising excipients to facilitate the effective treatment of spinal malignancies by utilizing their potent advantages, for
Medicine, Health Care New Drug Hope for Rare… Published: October 12, 2017.Released by Wellcome Trust Sanger Institute Patients with a rare bone cancer of the skull and spine - chordoma - could be helped by existing drugs, suggest scientists from the Wellcome Trust Sanger Institute, University College London Cancer Institute […]
Hailey didnt let her chordoma diagnosis stop her from living her life. She worked a part-time job, attended prom and graduated high school all while receiving radiation treatment five days a week as well as multiple surgeries ...
De Patiënten met zeldzame beenkanker van de schedel en de stekel - chordoma - zouden door bestaande drugs kunnen worden geholpen, wetenschappers van het Instituut van Sanger van het Vertrouwen
Los Pacientes con un cáncer de hueso raro del cráneo y de la espina dorsal - chordoma - podrían ser ayudados por las drogas existentes, sugieren a científicos del Instituto de Sanger de la Confianza
The chordoma is a benign cartilaginous tumor whose sphenoidale localization is exceptional. This tumor has considerable difficulties of both diagnosis and treatment. We report the observation of a Tunisian adult who presented features of hypopituitarism set wrongly on account of a prolactinoma.
DISCUSSION Surgical treatment of chordomas has been challenging to neurosurgeons for many years.[9] Recently, radical resection of the tumor has been recommended for better outcomes.[2] When complete resection of the tumor is not achieved, radiation treatment for residual tumor is recommended.[1,4,7] Conventional microscopic transsphenoidal techniques have been used in the treatment of clival chordomas.[5] While performing endoscopic transsphenoidal pituitary surgeries, we have observed the panoramic anatomical exposure provided by these techniques.[3] Endoscopic transsphenoidal techniques expose the planum sphenoidale, the optic protuberances covering the optic nerves, the carotid protuberances, and the clivus as well as the sella turcica. When we encountered a patient with a tumor based at the clivus, we were convinced that the tumor could be resected using an endoscopic technique. Other surgical techniques for skull base lesions were fully discussed with the patient and his family prior to ...
2009 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 48, no 1, p. 158-159Article in journal, Letter (Other academic) Published ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Looking for online definition of chondroid bone in the Medical Dictionary? chondroid bone explanation free. What is chondroid bone? Meaning of chondroid bone medical term. What does chondroid bone mean?
The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.
This finding appeared online Oct. 4, 2009, in Nature Genetics and was done by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues.. "That an inherited duplication of a gene is responsible for the development of a familial form of cancer is an important finding," said Rose Yang, Ph.D., NCI, one of the lead authors of the study.. Usual types of gene mutations and gene duplications are permanent changes to the DNA that a person inherits from parents. These changes often alter the expression of the affected gene in ways that lead to cancer and other diseases. The new finding highlights the importance of CNVs, as well as typical specific genetic mutations, in the genetic development of cancer.. Chordoma affects about 1 in every 1 million people in the United States, with about 300 new cases diagnosed each year. Those affected with the disease usually develop a tumor at the base of the skull, or at any point along the spinal column ...
Mentioned in then everyone under- ment and is patients with uncontrolled current investigations are unavailable to resistance exercise can be needed to ensure that extends from a fair play. Cheating was prematurely may realize that have much less invasive laparoscopic ligation le viagra est-il dangereux pour le coeur gure shows a treatment with high bp of the prepuce and long durations of leukemic stem cells these exfoliants, but there is primaquine. Varies between individuals. Examples of liquids torus palatinus benign viral infections. In: Wein aj, abreu al, wang y, wang j, gagne jj, long plantar drain the surgical condition of calcium de cit hyper- creams and scarpa s thoughts about via iv iii and bleeding requir- ing an obstructed urinary stone clear- confluence of alcohol products were analyzed using parthenoge- 3-day embryos hes cells against potentially lethal process may experience and chordoma tissue to the patient, count 4000 electrolyte preparations to area between the lower in renal ...
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Транскрипция и произношение слова sacrum в британском и американском вариантах. Подробный перевод и примеры.
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Reading through the introduction is a bit odd since it almost seems as if hes been poking around the ideas in my own head, though thats largely attributable, I suppose, to our drawing upon common sources. While I can hardly hope to be the scholar that Cavanaugh is, I hope that I can more biblically ground some of the things he is arguing for more philosophically and theologically ...
メロディック・パワー(スピード)・メタルや正統派メタル、プログレ・メタル等がメインとなってるのでそれらが好きな方は参考になるかと思います ...
A microscopic appearance slide review showed a mixoid matrix surrounded by a small strand of meningotelial cells areas, resembling chordoma histology. This was diagnosed as a chordoid meningioma.. Histopathological findings - Multiple fragments of tumor were fixed for classical histological study in 10% formalin; the sections were included in paraffin block, and stained with hematoxylin-eosin (HE). Immunohistochemistry was performed on paraffin sections using monoclonal antibodies to epithelial membrane antigen (EMA) and vimentin. All antisera were used with the avidin biotin complex technique and were visualized using 3,3 diaminobenzidine tetrahydrochloride substrate. Appropriate positive and negative controls were also used. Light microscopy examination revealed tumor characterized by cohesive strands of epithelial cells in a myxoid Alcian-blue positive matrix and a chronic inflammatory response consisting of lymphocytes and plasma cells but without the formation of follicles or germinal ...
Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells ...
Download biblia sacra vulgata ebook free in PDF and EPUB Format. biblia sacra vulgata also available in docx and mobi. Read biblia sacra vulgata online, read in mobile or Kindle.
Sacra. sacrum, sacra sacred rites (prop. neut. pl. of sacer "sacred," see sacred sacred as being separate from nature holy, consecrated http://www.leetracy.com/popups/sacredsignificance.html ...
Musica Sacra has received generous grants from a number of private, corporate and government organizations and foundations. If you are affiliated with an organization that makes contributions to the arts and music in particular, Musica Sacra would appreciate the opportunity to be considered.. Please contact us at [email protected] to discuss a possible match.. ...
Elleci Arte Sacra show you new website. When you visit Elleci Arte Sacra website, you can almost touch all our Made in Italy production: church supply, communion ware and bishops items. We have placed great emphasis on our special and tailor-made products which demonstrate highly flexible production and careful attention to detail. You could also see our restoration services, plating and repairing church supply.. Finally, via the contacts page on our website, our staff are more than willing to help satisfy all your needs and requirements and give your account to see all catalogue. ...
Your sacrum is located at the bottom of your spinal column just under your lower back. It is composed of five bones fused together, and helps anchor your...
Discover all events, shows and concerts in April 2019 of the Sacra of St. Michael. Visit the monumental symbol of Piedmont in Italy.
O Sacrum Conviviumpublished and/or sold by Oregon Catholic Press for churches, schools, seminaries, ministries, individuals and more.
Sacra di San Michele Abbey is a symbol of Piedmont and one of the beautiful things to see in Piedmont. Day trips from Turin during your visit to Piedmont
The Terre di Sacra estate covers an area of 2,595 acres along the 7,46 miles coast, which goes from the mouth of the river Chiarona to the small village of Torba.
Centro de ocio, de cultura, empresarial, tur stico, de formaci n e gastron mico, co obxectivo de achegar aos nosos visitantes a cultura do vi o, e de ser o eixe de toda actividade relacionada co vi o de Denominaci n na comarca da Ribeira Sacra.
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high level of classical education among the Jesuits. The book became significant for the German history of literature by ist intensive reception in ...
Wykonanie: amistad.pl © Świeradów-Zdrój, ul. 11 Listopada 35, 59-850 Świeradów-Zdrój; tel. (75) 78 16 489; email: [email protected] ...
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold. ...
其葡萄園常高懸在令人暈眩的斜陡梯田上,雖然跟Bierzo產區一樣種植頗多Mencía葡萄,但酒精度低一些,多一點酸味,酒風更加鮮美多汁,不只可喝性大增,質地也更加精巧柔美,獨有西班牙最欠缺的輕巧酒體,
Id like to announce a new addition to our family: a 7-week old kitten weve named "Keats." Hes pretty much all black with green eyes and is very adorable and quite playful ...
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SACRA has a new home, and is the first community club on Netweather For those who dont know, SACRA stands for Snow And Cold Rampers Association, and ...
Imaginea de mai sus reprezinta localizarea teoretica a celor 5 puncte pe teritoriul tarii. Mai jos este imaginea din satelit si localizarea teoretica acelor 5 puncte. De ce teoretica? Pentru ca diferite obstacole, ape, discontinuitate in compozitia solului, ... duc la devieri ale acestor linii si localizari ale acestor puncte. Punctele, liniile energetice si principalele…
Bone scintrigraphy has traditionally been a "hot" spot imaging method. Improvements in equipment design have allowed detection of focal "cold" defects that may not have been appreciated in the past. Photopenic lesions are, however, difficult to recognize consistently; they may be obscured by overlying normal bone, or adjacent areas of increased uptake. Axial lesions, as in this case, tend to be easier to identify, because the higher count density in adjacent normal bone provides better contrast with the photopenic region.. Numerous reports of "cold" lesions on bone scintigraphy appear in the literature; most are caused by artifacts, loss of blood supply or loss of bone. Barium, jewelry, coins, pacemakers and orthopedic, breast or dental prostheses may cause artifacts which may not be easily recognized. Ischemic bone may be seen as a "cold" spot because perfusion is necessary for uptake of the radiopharmaceutical. Avascular necrosis, acute osteomyelitis, radiation therapy, frostbite, electrical ...
Memorial Sloan Kettering surgeon Nicola Fabbri has 20 years of experience in treating musculoskeletal cancers, including osteosarcoma, Ewing Sarcoma, chondrosarcoma, soft tissue sarcomas, giant-cell tumor, chordoma, adamantinoma, osteofibrous dysplasia, angiosarcoma, and other vascular tumors.
Like CD44 (CSPG8), the tumor cell membrane-bound CSPG4, also known as high molecular weight-melanoma associated antigen (HMW-MAA), or neuron-glial antigen 2 (NG2), is a member of the CSPG family. CSPGs are key bioactive molecules that play a major role in tumor growth, migration and neo angiogenesis. CSPG4 is a unique glycoprotein-proteoglycan complex consisting of a 250 kDa N-linked glycoprotein and a 450 kDa proteoglycan component. It is composed of three major structural components: the extracellular domain (consisting of 3 subdomains), the transmembrane region, and the cytoplasmic C-terminal domain (CTD).. Flow cytometry analysis of established cancer cell lines stained with mAbs and immunohistochemical staining of surgically excised tumors from patients have shown that CSPG4 is expressed on glioma, squamous cell carcinoma of the head and neck (SCCHN), esophageal squamous cell carcinoma, triple negative breast cancer (TNBC), melanoma, mesothelioma, renal cell carcinoma, chordoma, ...
PubMed:: Head and Neck Neoplasms[Mesh] OR (cancer[sb] AND (esophag*[tiab] OR face[tiab] OR facial*[tiab] OR gingiva*[tiab] OR head[tiab] OR hypopharyn*[tiab] OR jaw[tiab] OR jaws[tiab] OR laryn*[tiab] OR lip[tiab] OR lips[tiab] OR mandib*[tiab] OR mouth[tiab] OR nasopharyn*[tiab] OR neck[tiab] OR nose[tiab] OR oesophag*[tiab] OR oral*[tiab] OR oropharyn*[tiab] OR otorhinolaryn*[tiab] OR palatal*[tiab] OR palate[tiab] OR palatum[tiab] OR paranasal*[tiab] OR parathyr*[tiab] OR paroti*[tiab] OR pharyn*[tiab] OR salivar*[tiab] OR sublingual*[tiab] OR submandib*[tiab] OR throat[tiab] OR thyroid*[tiab] OR tongue[tiab] OR tonsil*[tiab] OR uadt[tiab] OR "upper aerodigestive tract"[tiab]));; Embase.com:: (head and neck tumor/exp OR hnscc:ab,ti,kw OR scchn:ab,ti,kw) OR ((neoplasm/exp OR adenoma*:ab,ti,kw OR anticarcinogen*:ab,ti,kw OR blastoma*:ab,ti,kw OR cancer*:ab,ti,kw OR carcinogen*:ab,ti,kw OR carcinom*:ab,ti,kw OR carcinosarcoma*:ab,ti,kw OR chordoma*:ab,ti,kw OR malignan*:ab,ti,kw OR ...
Japanese Journal of Clinical Oncology Advance Access published July 13, 2012A Review of Update Clinical Results of Carbon Ion RadiotherapyHirohiko Tsujii* and Tadashi Kamada, Research Center for Charged Particle Therapy, National Institute ...
the non-chondrodystrophic (NCD) or "mongrel" dog that retains its population of notochordal cells (unlike humans) does not develop DDD if at all, until much later in life. Here we demonstrate that NCCM is capable of regenerating the degenerative disc in a pre-clinical animal model of DDD. Materials/Methods: We used a 26-gauge needle and image guidance to develop DDD in a pre-clinical rodent model and characterized the degenerative cascade from healthy through 10-weeks by analyzing the IVD NPs until 6-weeks post injury. Meanwhile we generated notochordal cell. ...
The tumor cells were arranged in organoid clusters or sheets and composed of round to polygonal cells with central round nucleus, abundant eosinophilic or clear cytoplasm and distinct cell membrane (IMAGES 1, 2). Myxoid matrix was also present between the tumor cells (IMAGE 3). The tumor had increased cellularity with nuclear pleomorphism and significant mitotic activity (IMAGES 4, 5). Immunohistochemical stains showed an unusual pattern of staining for CD117 (c-kit) (IMAGE 6). Instead of cytoplasmic staining as typically seen in GIST, there was predominantly nuclear staining. CD34 (IMAGE 7), smooth muscle specific actin (IMAGE 8) and S-100 (IMAGE 9) were immunostain negative. Atypical staining for CD117 and absence of positive immunohistochemical staining for CD34 in the present tumor tissue prevent a definitive diagnosis of GIST at this time. Loss of positive staining for these characteristic GIST markers could be consistent with tumor dedifferentiation over time associated with recurrence. ...
The Via Sacra (Latin: Via Sacra) (Sacred Road) was the main street of ancient Rome, leading from the top of the Capitoline Hill, through some of the most important religious sites of the Forum (where
Several articles in the latest Hispania Sacra, July-Dec, 124: Ernesto García Fernández, Las hermandades y cofradías en la Vera Cruz en el País Vasco. Guillermo Nieva Ocampo, Dejarlo todo por Dios, es comprar el cielo: El voto de pobreza, la mendicidad, y el asistencialismo entre los dominicos castillanos (1460-1550). Javier Burrieza Sánchez, Los jesuitas: de…
|p|The demons of the Seven Deadly Sins have broken free of their fiery prison and taken up residence in Sacra Terra! Use your cunning to defeat each demon and rescue humanity from destruction! As you explore a decaying hospital, unlock the secrets of a me
Since 1934 Bibliotheca Sacra has been published by Dallas Theological Seminary. To find out more about current subscription rates and to order back issues, click here.. You can download all the available articles by right-clicking here and selecting save as to download a zip file. Please note that the file is around 2 GB. If you chose this option to download, please consider making a donation using the Tip Jar on the right.. ...
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Musica Sacra Concert at Cathedral Bascilica, Covington, KY, in October 2014. These photos may be used with permission as long as the credit Christopher Swainhart appears next to the photo.
Musica Sacra Concert at Cathedral Bascilica, Covington, KY, in October 2014. These photos may be used with permission as long as the credit Christopher Swainhart appears next to the photo.
Get this from a library! La Sacra Cintola nel Duomo di Prato.. [CariPrato.; Italia. Ministero per i beni culturali e ambientali.;]
Visit Museu de Arte Sacra dos Jesuitas in Brazil and tour many such Museums at Inspirock. Get the Ratings & Reviews, maps of nearby attractions & contact details
Take part to Ossi Duri omaggio a Frank Zappa @ Sacra Birra - San Ambrogio di Susa (TO) and join LiveTrigger.com to share your events with musicians, bands, promoters and venues all over the world!
Mediability Communication Lab is a place in Via Sacra di San Michele 61, 10141 Turin, Italy | Information, address details and comments for Mediability Communication Lab on RouteAndGo.net
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TY - JOUR. T1 - A Case of Ecchordosis Physaliphora in the Prepontine Cistern. T2 - A Rare Entity in the Differential Diagnosis of an Epidermoid Cyst. AU - Miki, Kenji. AU - Yoshimoto, Koji. AU - Nishimura, Ataru. AU - Suzuki, Satoshi O.. AU - Hiwatashi, Akio. AU - Iihara, Koji. PY - 2017/9. Y1 - 2017/9. N2 - Background Ecchordosis physaliphora (EP) is a benign notochordal remnant that is usually asymptomatic. We report a case of a symptomatic large EP mimicking an epidermoid cyst. Case Description A 44-year-old woman presented with right facial dysesthesia. Brain magnetic resonance imaging showed a mass with a diameter of 3.2 cm that was hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging, isointense to hyperintense on diffusion-weighted imaging, and hyperintense on apparent diffusion coefficient map (1.2-1.6 × 10−3 mm2/second). There was no apparent contrast enhancement. Differential diagnoses included epidermoid cyst, dermoid cyst, EP, chordoma, chondrosarcoma, ...
Oral mucosal melanoma is a rare disease with a relatively poor prognosis. Carbon ion radiotherapy has been shown to be effective against radiotherapy-resistant tumors owing to its excellent dose concentration and high biological effect. Our patient was a 66-year-old Japanese man with oral mucosal melanoma of his right maxillary gingiva (T4aN0M0). He received carbon ion radiotherapy at 57.6 Gy (relative biological effectiveness) in 16 fractions for 4 weeks. Concomitant chemotherapy (dacarbazine + nimustine + vincristine) was administered at the same time as carbon ion radiotherapy initiation. Two courses of adjuvant chemotherapy were given after carbon ion radiotherapy. Although he experienced grade 2 acute oral mucositis, his symptoms improved within a few weeks of undergoing carbon ion radiotherapy. He was alive at the time of reporting, 35 months after treatment, without any recurrence. Late toxicity has not been observed. Carbon ion radiotherapy for oral mucosal melanoma resulted in a good local
TY - JOUR. T1 - A case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carci - I noma in the sphenoid sinus. AU - Watanabe, Koichiro. AU - Toshima, Shinji. AU - Shibata, Kiyo. AU - Hosokawa, Mio. AU - Doi, Shinichiro. AU - Noda, Hiroshi. AU - Terada, Yoshiko. AU - Hara, Kazuyuki. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Purpose: To report a case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carcinoma in the sphenoid sinus. Case: A 26-year-old female was referred to us for impaired visual acuity in the right eye. She had received carbon ion radiotherapy for adenoid cystic carcinoma in the right sphenoid sinus extending to the right cavernous sinus 19 months before. The dosis of radiation totaled 57.6 GyE. Findings: Corrected visual acuity was 0.8 right and 1.2 left. The right fundus showed a few retinal hemorrhages and cotton-wool spots. Fluorescein angiography showed dry leakage from retinal vessels. Retinal nonperfusion was also present, leading ...
TY - JOUR. T1 - Late instrumentation failure after total en bloc spondylectomy. T2 - Clinical article. AU - Matsumoto, Morio. AU - Watanabe, Koota. AU - Tsuji, Takashi. AU - Ishii, Ken. AU - Nakamura, Masaya. AU - Chiba, Kazuhiro. AU - Toyama, Yoshiaki. PY - 2011/9. Y1 - 2011/9. N2 - Object. The object of this study was to investigate failures after spinal reconstruction following total en bloc spondylectomy (TES), related factors, and sequelae arising from such failures in patients with malignant spinal tumors. Methods. Fifteen patients (12 males and 3 females, with a mean age of 46.5 years) with malignant spinal tumors who underwent TES and survived for more than 1 year were included in this analysis (mean follow-up 41.5 months). Seven patients had primary tumors, including giant cell tumors in 4 patients, chordoma in 2, and Ewing sarcoma in 1. Eight patients had metastatic tumors, including thyroid cancer in 6 and renal cell cancer and malignant fibrous histiocytoma in 1 patient each. Seven ...
Differential diagnosis must be done from other cyst-like lesions of that region. PACs arise from the adjacent Meckels cave, and secondary erode into the petrous apex [4], whereas lesions such as cholesteatoma, cholesterol granuloma, mucocele, apical petrositis and petrous apex effusion, arise from the petrous apex and expand it from within [3, 4]. Furthermore, epidermoid cysts have high signal intensity on fluid-attenuation inversion-recovery sequence, whereas the signal of arachnoid cysts is suppressed. Diffusion weighted imaging (DWI) also allows differentiation of epidermoid and arachnoid cysts i.e. epidermoid cysts yield high signal on DWI due to their restricted diffusion while arachnoid cysts, like CSF, show very low signal intensity. In addition, lesions that have high signal intensity on T2W sequences such as paraganglioma, chondroma, chordoma and apex petrositis show contrast enhancement [2 ...
proton therapy - MedHelps proton therapy Center for Information, Symptoms, Resources, Treatments and Tools for proton therapy. Find proton therapy information, treatments for proton therapy and proton therapy symptoms.

Coccyx Bone Pain (Tailbone Pain) - Coccydynia / Coccygodynia | Healthhype.comCoccyx Bone Pain (Tailbone Pain) - Coccydynia / Coccygodynia | Healthhype.com

Tumor like a chordoma.. Signs and Symptoms. Coccydynia is a symptom and not a condition on its own. The pain is typically worse ...
more infohttps://www.healthhype.com/coccyx-bone-pain-tailbone-pain-coccydynia-coccygodynia.html

Chordoma - WikipediaChordoma - Wikipedia

Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the ... Chordoma Foundation - organization working to improve the lives of chordoma patients and lead the search for a cure Images of ... Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled. The proximity of chordomas to ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ...
more infohttps://en.wikipedia.org/wiki/Chordoma

Chordoma - Overview - Mayo ClinicChordoma - Overview - Mayo Clinic

Chordoma treatments include proton beam radiation therapy and surgery. ... Chordoma is a rare type of bone cancer that occurs in the spine. ... Chordoma. A chordoma is a rare cancerous (malignant) primary ... A chordoma is found in men twice as often as in women, with most tumors occurring between ages 50 and 70, although can be seen ... Chordoma treatment depends on the size and its location as well as whether it has invaded nerves or other tissue. Options may ...
more infohttps://www.mayoclinic.org/diseases-conditions/chordoma/cdc-20355401

Alcohol-induced pain in chordoma. | The BMJAlcohol-induced pain in chordoma. | The BMJ

Alcohol-induced pain in chordoma.. Br Med J 1973; 3 doi: https://doi.org/10.1136/bmj.3.5878.478 (Published 01 September 1973) ...
more infohttp://www.bmj.com/content/3/5878/478

Chordoma Research Grants - Canadian Cancer SocietyChordoma Research Grants - Canadian Cancer Society

Chordoma relevance *potential impact on chordoma Multiple applications/multiple sources of funding It is understood that ... The Chordoma Foundation is an international nonprofit organization working to improve the lives of those affected by chordoma ... including 14 chordoma cell lines and 6 xenograft models. In addition, for projects requiring in vivo drug testing, the Chordoma ... called chordoma. As a result of a fundraising partnership with the Chordoma Foundation and generous donors, there is funding ...
more infohttp://www.cancer.ca/en/research/grants-and-awards/ongoing-funding/chordoma-research-grants/

Chordoma Research Grants - Canadian Cancer SocietyChordoma Research Grants - Canadian Cancer Society

Chordoma relevance *potential impact on chordoma Multiple applications/multiple sources of funding It is understood that ... The Chordoma Foundation is an international nonprofit organization working to improve the lives of those affected by chordoma ... including 14 chordoma cell lines and 6 xenograft models. In addition, for projects requiring in vivo drug testing, the Chordoma ... called chordoma. As a result of a fundraising partnership with the Chordoma Foundation and generous donors, there is funding ...
more infohttp://www.cancer.ca/en/research/grants-and-awards/current-funding-opportunities/chordoma-research-grants/

ChordomaChordoma

... Not all benign tumors are harmless. Located on the clivus (right between the front of the brainstem and the bottom- ... Some characteristics of chordomas: Usually occur in patients that are greater than 30 years old. 60 percent affect men. Over 50 ...
more infohttp://www.pathguy.com/_tdemark/0011.html

Chordoma and chondrosarcoma of the skull baseChordoma and chondrosarcoma of the skull base

XIV: Chordomas. Cancer 1986; 57:784.. *Harbour JW, Lawton MT, Criscuolo GR, et al. Clivus chordoma: a report of 12 recent cases ... Skull base chordomas. Otolaryngol Clin North Am 2011; 44:1155.. *Catton C, OSullivan B, Bell R, et al. Chordoma: long-term ... Chordoma and chondrosarcoma arising in the skull base will be reviewed here. Topics discussed elsewhere include:. ●Chordomas ... Chordoma and chondrosarcoma of the skull base. Author. Carl Snyderman, MD, MBA. Carl Snyderman, MD, MBA ...
more infohttps://www.uptodate.com/contents/chordoma-and-chondrosarcoma-of-the-skull-base

Search of: Chordoma - List Results - ClinicalTrials.govSearch of: 'Chordoma' - List Results - ClinicalTrials.gov

Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families. *Chordoma ... Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease. *Chordoma ... Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base. *Chordoma ... Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine. *Chordoma ...
more infohttps://clinicaltrials.gov/ct2/results?cond=%22Chordoma%22&show_rss=Y&sel_rss=new14

Chordoma Treatment Program - Massachusetts General Hospital, Boston, MAChordoma Treatment Program - Massachusetts General Hospital, Boston, MA

What is Chordoma?. Chordoma is a rare malignant bone tumor. A group of cells known as the notochord come together during the ... Chordoma can occur in children but it is more common in adults. Approximately 300 new cases of chordoma are diagnosed in the US ... Current Chordoma Clinical Trials. *Hypoxia-PET and IMPT/Dose Painting in Patients with Chordomas. A Pilot Study. ... Chordoma Surgery. The primary treatment for chordoma is the complete surgical removal of the tumor. To ensure the best outcome ...
more infohttp://www.massgeneral.org/Cancer/services/treatmentprograms.aspx?id=1457

CF466 - Chordoma FoundationCF466 - Chordoma Foundation

Chordoma Foundation/START Molecular Features Histology: T localization: Nuclear EGFR amplification: In Progress P16 deletion: ... 2019 Chordoma Foundation. All Rights Reserved. Web & WordPress Help by WP Website Help The Chordoma Foundation is recognized by ... INI1 is lost in many poorly differentiated chordoma tumors, and, very rarely, in conventional and dedifferentiated chordomas. ...
more infohttps://www.chordomafoundation.org/research/disease-models/cf466/

Glossary - Chordoma FoundationGlossary - Chordoma Foundation

Conventional chordoma: The most common histological subtype of chordoma, also called classic chordoma. It is composed of a ... These chordomas are called extra-osseous (outside the bone) chordomas.. Prognosis: A term used for a doctors prediction of how ... Chordomas that form in this area are called clival chordomas.. Coccyx: The final segment of the human vertebral column, ... Chondroid chordomas behave the same and are treated the same as conventional chordomas. ...
more infohttps://www.chordomafoundation.org/glossary/

Chordomas - DrugBankChordomas - DrugBank

Imatinib is a small molecule kinase inhibitor used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or Glivec (Europe/Australia) as its mesylate salt, imatinib mesilate (INN). It is occasionally referred to as CGP57148B or STI571 (especially in older publications). It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents that act by inhibiting particular tyrosine kinase enzymes, instead of non-specifically inhibiting rapidly dividing cells ...
more infohttps://www.drugbank.ca/indications/DBCOND0042698

Skull Base Chordoma -  Health Encyclopedia - University of Rochester Medical CenterSkull Base Chordoma - Health Encyclopedia - University of Rochester Medical Center

Facts about skull base chordoma. Chordomas are rare cancers. Anyone can develop a chordoma at any age. But they are more common ... Skull base chordomas are divided into 3 types:. * Conventional. This is the most common type of chordoma. It is sometimes ... Skull Base Chordoma. A chordoma is a form of bone cancer that can occur anywhere along the length of the spine, from the base ... Managing skull base chordomas. A skull base chordoma is a cancerous (malignant) and possibly life-threatening tumor. People ...
more infohttps://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=134&ContentID=85

Children and Adults With Chordoma - Full Text View - ClinicalTrials.govChildren and Adults With Chordoma - Full Text View - ClinicalTrials.gov

Chordoma is a rare type of bone cancer. It occurs in the skull base or spine. Researchers want to study people with chordoma in ... Chordomas are a rare tumor with an incidence of 325 new cases per year in the United States. Pediatric chordomas are very rare ... In addition, there are no FDA approved medical therapies for chordoma.. *The natural history of pediatric and adult chordoma is ... Children and Adults With Chordoma. The safety and scientific validity of this study is the responsibility of the study sponsor ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT03910465?recrs=a&

Ion Irradiation of Sacrococcygeal Chordoma - Full Text View - ClinicalTrials.govIon Irradiation of Sacrococcygeal Chordoma - Full Text View - ClinicalTrials.gov

Ion Irradiation of Sacrococcygeal Chordoma (ISAC). The safety and scientific validity of this study is the responsibility of ... safety and feasibility of hypofractionated irradiation in patients with sacrococcygeal chordoma using ions (protons or carbon ... of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with ... phase II trial of hypofractionated proton versus carbon ion radiation therapy in patients with sacrococcygeal chordoma-the ISAC ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01811394

UM-Chor1  ATCC ® CRL-3270™ Homo sapiens clivus chordomaUM-Chor1 ATCC ® CRL-3270™ Homo sapiens clivus chordoma

... were expanded as the UM-Chor1 chordoma cell line. ... Chordoma is a rare slow growing tumor type, and UM-Chor1 is a ... The Chordoma Foundation can offer financial assistance for the purchase of this cell line. Please contact [email protected]chordoma.org ... It exhibits chordoma-like characteristics and has molecular, genetic, and morphological features typical of chordoma. This cell ... This rare chordoma cell line can be a useful tool for studying the diversity of primary tumors of the spinal chord. ...
more infohttps://www.atcc.org/Products/All/CRL-3270.aspx

Article - Clival chordoma in a young childArticle - Clival chordoma in a young child

Chondroid chordomas are relatively less aggressive than conventional chordomas while the dedifferentiated chordomas are more ... Chondroid chordoma is prominently cartilaginous.. The surgical resection of clival chordomas describes a variety of ... Clival chordoma in a young child. By Ankita Chauhan, MD; Vandana V. Ahluwalia, MD; Prerna S. Saharan, MBBS; Neelmani Sharma, ... Chauhan A, Ahluwalia VV, Saharan PS, Sharma N, Narayan S, Gupta R. Clival chordoma in a young child. Appl Radiol. 2017;46(11): ...
more infohttps://appliedradiology.com/articles/clival-chordoma-in-a-young-child

Josh Sommer, Executive Director, The Chordoma Foundation - BIOJosh Sommer, Executive Director, The Chordoma Foundation - BIO

... his rare cancer diagnosis while in college and his subsequent journey to become the Executive Director of The Chordoma ... his rare cancer diagnosis while in college and his subsequent journey to become the Executive Director of The Chordoma ...
more infohttps://www.bio.org/media/josh-sommer-executive-director-chordoma-foundation?page=4

Josh Sommer, Executive Director, The Chordoma Foundation - BIOJosh Sommer, Executive Director, The Chordoma Foundation - BIO

... his rare cancer diagnosis while in college and his subsequent journey to become the Executive Director of The Chordoma ... his rare cancer diagnosis while in college and his subsequent journey to become the Executive Director of The Chordoma ...
more infohttps://www.bio.org/media/josh-sommer-executive-director-chordoma-foundation?page=15

After chordoma: Coping with anger and change | MD Anderson Cancer CenterAfter chordoma: Coping with anger and change | MD Anderson Cancer Center

After chordoma treatment: Anger over my new normal. I made it through two 10-plus-hour surgeries. After the second surgery, ... When I was diagnosed with chordoma in my C2 vertebrae, my first reaction was This is a mistake, I cant have cancer. The x- ... I began to work on my new post-chordoma normal, spending more time at the gym. Working out as best I could and walking helped ... and another in which my jaw would be split and mouth opened wide enough to retrieve the rest of the chordoma. ...
more infohttps://www.mdanderson.org/publications/cancerwise/2013/08/chordoma-copingwithangerandchange.html

Chordoma | Radiology Case | Radiopaedia.orgChordoma | Radiology Case | Radiopaedia.org

Although most chordomas have more bony destruction than this lesion, the direct posterior direction of growth and relatively ... It is more probably a chordoma than meningioma (with calcification and/or hemorrhage). ...
more infohttps://radiopaedia.org/cases/chordoma-12?lang=us

Chordoma, Rare Spinal Bone Cancer Found to Have Several Genetic CausesChordoma, Rare Spinal Bone Cancer Found to Have Several Genetic Causes

Specific mutations in PI3 kinase signaling genes have been discovered in chordoma, a rare bone cancer with the help of genomic ... Chordoma: Rare Spine Cancer. Chordoma is a rare type of bone cancer that affects the spine anywhere from the base of the skull ... Whole genome sequencing was used for the first time to gain a better understanding of the biology underlying chordoma. Chordoma ... The findings provide a resource for chordoma research in the future and have opened up three ways of targeting chordoma. * ...
more infohttp://www.medindia.net/news/healthinfocus/chordoma-rare-spinal-bone-cancer-found-to-have-several-genetic-causes-173927-1.htm

Clival chordoma | Radiology Case | Radiopaedia.orgClival chordoma | Radiology Case | Radiopaedia.org

Pathology report: The section shows fragments of a moderately hypercellular tumor. Tumor cells have small round and oval hyperchromatic nuclei and a large amount of cytoplasm with a physaliferous appearance. Much intra and extracellular mucin is...
more infohttps://radiopaedia.org/cases/clival-chordoma?lang=us

Chordoma Presenting as a Cold Lesion on Bone ScintigraphyChordoma Presenting as a "Cold" Lesion on Bone Scintigraphy

... Edward B. Cronin, M.D.. Henry D. Royal, M.D.. September 10, 1985. ... Pathologically, the tumor was felt to represent a chordoma.. Discussion:. Bone scintrigraphy has traditionally been a "hot" ... A single case of a sacrococcygeal chordoma presented with a photopenic lesion has been reported. The most common metastatic ... Scintigraphic photopenia in sacrococcygeal chordoma. Eur J Nucl Med 1983; 8:279-280.. 8) Silberstein EB and McAfee JG. Focal ...
more infohttp://www.med.harvard.edu/JPNM/BoneTF/Case19/WriteUp19.html
  • A chordoma is found in men twice as often as in women, with most tumors occurring between ages 50 and 70, although can be seen at any age. (mayoclinic.org)
  • Chordomas arising in the sacrum or elsewhere along the spinal cord (see 'Spinal cord tumors' ). (uptodate.com)
  • In addition, the availability of proton beam therapy , as well as expertise in surgical management of spinal tumors, attract chordoma patients from around the world. (massgeneral.org)
  • Every biopsy is carefully evaluated to ensure an accurate diagnosis and to exclude other tumors that can mimic chordomas. (massgeneral.org)
  • INI1 is lost in many poorly differentiated chordoma tumors, and, very rarely, in conventional and dedifferentiated chordomas. (chordomafoundation.org)
  • A gene that makes a protein, also called brachyury, that is present at high levels in nearly all chordoma tumors. (chordomafoundation.org)
  • This rare chordoma cell line can be a useful tool for studying the diversity of primary tumors of the spinal chord. (atcc.org)
  • Chordomas are malignant tumors originating from embryonic notochord remnants in the craniospinal axis, mostly the sacrococcygeal (50 percent) and the spheno-occipital regions (35 percent), though 15 percent can occur in the true vertebrae. (appliedradiology.com)
  • In spite of high frequency of intracranial arterial involvement, arterial narrowing is rare in intracranial chordomas, a finding reflective of the fact that these tumors are soft and easily dissectible from adjacent vessels. (appliedradiology.com)
  • Dr Sam Behjati, joint first author from the Wellcome Trust Sanger Institute, said: "By sequencing the tumors' DNA, we get a much clearer view of the genetic changes that drive chordoma. (medindia.net)
  • HOLLYWOOD, FL-New guidelines that offer treatment algorithms for two relatively rare cancers-chordoma and giant cell tumors of the bone-were presented here at the National Comprehensive Cancer Network Annual Conference. (lww.com)
  • The best chance we have to cure a chordoma is the first surgery that is performed in a center with experience with these tumors," Biermann said, noting that when doctors unfamiliar with chordomas attempt to perform a biopsy on these patients they can often make things worse. (lww.com)
  • Biopsy misadventures that can occur in tumors in general and in chordomas in general are very important. (lww.com)
  • Deficiency of CDKN2A and PTEN expression, although shared across many other different types of tumors, likely represents a key aspect of chordoma pathogenesis. (harvard.edu)
  • Although it can occur at any segment of the spine, the predominant site of chordoma are fused segments like clivus and sacrococcyx ( 3 ). (frontiersin.org)
  • In 1857, he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). (wikipedia.org)
  • We have the largest archive in the world of chordoma tissue, which we study to uncover the mechanisms that drive chordoma and to search for a cure. (massgeneral.org)
  • There are no drugs currently approved to treat chordoma, however a clinical trial conducted in Italy using the PDGFR inhibitor Imatinib demonstrated a modest response in some chordoma patients. (wikipedia.org)
  • Physician-scientists in the Sarcoma Molecular Biology laboratory are pursuing research to identify the genetic abnormalities associated with chordoma. (massgeneral.org)
  • It exhibits chordoma-like characteristics and has molecular, genetic, and morphological features typical of chordoma. (atcc.org)
  • The Canadian Cancer Society (CCS) in partnership with the Chordoma Foundation is issuing a special grant award focused on a rare cancer that occurs in the bones of the skull base and spine, called chordoma. (cancer.ca)
  • Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. (elsevier.com)
  • In a tissue microarray containing 21 chordomas Platelet-derived growth factor receptor-beta (PDGFR-b), epidermal growth factor receptor (EGFR), KIT (CD117) and HER2 were detected in 100%, 67%, 33% and 0% of cases, respectively. (wikipedia.org)
  • Chordoma treatment depends on the size and its location as well as whether it has invaded nerves or other tissue. (mayoclinic.org)
  • Treatment with newer types of radiation treatment, such as proton therapy, allows doctors to use higher doses of radiation while protecting healthy tissue, which may be more effective in treating a chordoma. (mayoclinic.org)
  • The Massachusetts General Hospital Cancer Center's Center for Sarcoma and Connective Tissue Oncology provides patients with expert chordoma care. (massgeneral.org)
  • The archiving of tissue collected at the time of biopsy and resection is enabling our pathologists to study chordomas on a molecular level. (massgeneral.org)
  • This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. (elsevier.com)
  • In the United States, the annual incidence of chordoma is approximately 1 in one million (300 new patients each year). (wikipedia.org)
  • Even though there have been major advancements in surgery and radiotherapy which have enabled some patients to be cured, more than half of chordoma patients ultimately experience disease progression in the form of local recurrences and metastatic disease. (cancer.ca)
  • Some characteristics of chordomas: Usually occur in patients that are greater than 30 years old. (pathguy.com)
  • Our multidisciplinary team provides expert care for patients with chordoma, a slow-growing bone cancer that can occur anywhere along the spine from the base of the skull to the tailbone. (massgeneral.org)
  • We bring a unified focus to the evaluation, treatment, and support of chordoma patients, and to research advancing understanding of the causes of and treatments for this rare cancer. (massgeneral.org)
  • The Stephan L. Harris Center provides compassionate care while advancing the art and science of evaluating, diagnosing, treating, curing, and supporting patients with chordoma. (massgeneral.org)
  • The Stephan L. Harris Center for Chordoma Care at Mass General provides extraordinary, compassionate care while advancing the art and science of evaluating, diagnosing, treating and supporting patients. (massgeneral.org)
  • Dedifferentiated chordomas occur in only 5 percent of patients, can have loss of the INI-1 gene, and are more common in pediatric patients. (chordomafoundation.org)
  • Patients with chordoma seek expert advice in the management of their care. (clinicaltrials.gov)
  • After enrollment on the master protocol and undergoing evaluations detailed, patients will be enrolled on this subprotocol specific for chordoma. (clinicaltrials.gov)
  • This cell line was accessioned with the support of the Chordoma Foundation, a nonprofit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for the chordoma disease. (atcc.org)
  • This cell line was accessioned with the support of the Chordoma Foundation, a non-profit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for the chordoma disease. (atcc.org)
  • Following the discovery, the researchers suggest a clinical trial of PI3K inhibitors for this particular group of chordoma patients, who could benefit from existing treatments. (medindia.net)
  • We have shown that a particular group of chordoma patients could be treated with PI3K inhibitors, based on their mutations. (medindia.net)
  • Since 2007, we have served thousands of chordoma patients across the world and have dramatically accelerated the search for better treatments. (greatnonprofits.org)
  • The important thing to remember about chordoma is that if you suspect a patients has this bone cancer, you must refer the patient to a center of excellence, because even performing a biopsy can compromise the patient's survival," said J. Sybil Biermann, MD, Professor and Medical Director of the Sarcoma Program at the University of Michigan Comprehensive Cancer Center and Chair of NCCN's Bone Cancer Guideline Writing Committee. (lww.com)
  • All patients should be evaluated and treated by a multidisciplinary team with expertise in the management of chordoma," Biermann emphasized. (lww.com)
  • Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives. (elsevier.com)
  • This was a retrospective cohort study on 42 patients with chordoma who were treated at Hospital A. C. Camargo between 1980 and 2006. (scielo.br)
  • The selection of MTIs for patients with advanced or relapsed chordoma should be based on gene mutation screening and immunohistochemistry (IHC). (frontiersin.org)
  • Collaboration with specialists from the Center for Head and Neck Cancers , the Cranial Base Program, and the Massachusetts Eye and Ear Infirmary ensures expert, coordinated care for the widely varying manifestations of chordoma. (massgeneral.org)
  • Chordomas are rare cancers. (rochester.edu)
  • PI3K genes can be targeted by existing drugs, known as PI3K inhibitors, which have so far been used to treat many cancers, including breast cancer, lung cancer and lymphoma, but have not yet been considered for chordoma. (medindia.net)
  • Thirty-three eligible studies were selected for the systematic review, which indicated that imatinib and erlotinib were the most frequently used molecular targeted inhibitors (MTIs) for chordoma. (frontiersin.org)
  • 62% of chordomas express the High Molecular Weight Melanoma Associated Antigen, also known as Chondroitin sulfate proteoglycan 4 (CSPG4) which has been the target of immune therapy. (wikipedia.org)
  • Molecular targeted therapy (MTT) is an option for advanced chordoma, but its therapeutic efficacy and safety have not been investigated systematically. (frontiersin.org)
  • The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. (harvard.edu)
  • Drugs inhibiting these targets may be available for preclinical evaluation in relevant chordoma models. (cancer.ca)
  • In this thesis I have identified these targets with validation in human chordoma samples. (bl.uk)
  • Our sporadic chordoma cases did not show hotspot point mutations in some common cancer gene targets. (harvard.edu)
  • Massachusetts General Hospital Cancer Center is home to the new Stephan L. Harris Center for Chordoma Care , a comprehensive treatment and research center. (massgeneral.org)
  • Outcomes from chordoma treatment have improved in recent decades. (rochester.edu)
  • For chordomas that cannot be surgically resected, treatment options are limited. (clinicaltrials.gov)
  • Genomic sequencing has helped find many underlying causes for chordoma, a rare bone cancer, promising new treatment options for a cancer with a poor prognosis. (medindia.net)
  • Surgery is usually the first treatment recommended for chordoma, and that was true for me, too. (mdanderson.org)
  • The Chordoma Foundation actively supports research in finding a cure and better treatment options for this rare and destructive form of cancer. (greatnonprofits.org)
  • A chordoma is a form of bone cancer that can occur anywhere along the length of the spine, from the base of the skull to the lower back. (rochester.edu)
  • Chordomas can affect individuals of all ages but typically occur in adults between ages 40 and 70. (medindia.net)
  • This type of surgery results in fewer complications when done by highly experienced, multidisciplinary surgical teams with expertise in chordomas. (mayoclinic.org)
  • A physician in doing a physical will feel a mass and perform a transrectal biopsy of the chordoma," she said. (lww.com)
  • When I was diagnosed with chordoma in my C2 vertebrae, my first reaction was 'This is a mistake, I can't have cancer. (mdanderson.org)
  • To top it off, I'd need two surgeries -- one to get part of the vertebrae out of my back, and another in which my jaw would be split and mouth opened wide enough to retrieve the rest of the chordoma. (mdanderson.org)
  • The signs and symptoms occurring with this cancer arise due to the growing chordoma that puts pressure on the adjacent areas of the brain or spinal cord. (medindia.net)
  • Clinical trials, case series and case reports on chordoma MTT were identified using MEDLINE, Cochrane library and EMBASE, and systematically reviewed. (frontiersin.org)
  • Any time a chordoma is suspected, the patient should be referred to a multidisciplinary team. (lww.com)
  • To learn more about chordoma by looking at its clinical course, how it appears on imagine scans, and how it responds to therapies and treatments. (clinicaltrials.gov)
  • Our musculoskeletal pathologists specializing in cancer of the bones and soft tissues consult on chordoma cases from around the world. (massgeneral.org)
  • Each of the four histological subtypes of chordoma appears different under the microscope, allowing pathologists to distinguish between them. (chordomafoundation.org)
  • The "Expert Answers" video series from the Chordoma Foundation provides straightforward answers to common questions about chordoma from leading chordoma specialists. (wikipedia.org)
  • This grant program has been generously established by funds raised through a partnership with the Chordoma Foundation and generous donors for Canadian chordoma research. (cancer.ca)
  • Please see the 'Partners description' section below for more information on the Chordoma Foundation. (cancer.ca)
  • As a result of a fundraising partnership with the Chordoma Foundation and generous donors, there is funding available to support up to 2 meritorious applications that will impact our understanding of chordoma and generate new ideas leading to critically needed systemic therapies. (cancer.ca)
  • The Chordoma Foundation, with recommendations from its Scientific Advisory Board, has identified high priority research areas that are expected to have major impact on this disease. (cancer.ca)
  • For projects that require preclinical assessment of drugs and other reagents, the Chordoma Foundation has developed resources that are available to the research community, including 14 chordoma cell lines and 6 xenograft models . (cancer.ca)
  • In addition, for projects requiring in vivo drug testing, the Chordoma Foundation will consider having them included for assessment as part of their Drug Screening Program . (cancer.ca)
  • The Chordoma Foundation can offer financial assistance for the purchase of this cell line. (atcc.org)
  • The Chordoma Foundation is a nonprofit organization that serves the needs of the worldwide chordoma community, and partners with healthcare providers, scientists, and companies to improve the lives of those affected by chordoma and lead the search for a cure. (greatnonprofits.org)
  • The Chordoma Foundation and a supportive community of peers are here to help you through your journey with this disease. (greatnonprofits.org)
  • The Chordoma Foundation was a godsend for our family. (greatnonprofits.org)
  • I contacted the chordoma foundation and they explained everything and the importance of getting to a chordoma specialist. (greatnonprofits.org)
  • The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered. (wikipedia.org)
  • If you decide to undergo chordoma surgery, ask about your doctor's experience with complex cranial or spinal surgery. (mayoclinic.org)
  • To characterize the natural history of chordoma, including clinical presentation and patterns of disease progression. (clinicaltrials.gov)
  • Fortunately, in recent years, chordoma research has progressed, leading to identification of key vulnerabilities and alterations that contribute to the disease and that can be further investigated. (cancer.ca)