A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
Tumors or cancer located in bone tissue or specific BONES.
Benign growths of cartilage in the metaphyses of several bones.
A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Glycoproteins which have a very high polysaccharide content.
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Cancer or tumors of the MAXILLA or upper jaw.
Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.
FIBROUS DYSPLASIA OF BONE involving only one bone.
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
The privacy of information and its protection against unauthorized disclosure.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Public Law 104-91 enacted in 1996, was designed to improve the efficiency and effectiveness of the healthcare system, protect health insurance coverage for workers and their families, and to protect individual personal health information.
Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
A disorder characterized by the accumulation of encapsulated or unencapsulated tumor-like fatty tissue resembling LIPOMA.
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.
A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
A benign tumor resulting from a congenital malformation of the lymphatic system. Lymphangioendothelioma is a type of lymphangioma in which endothelial cells are the dominant component.
Tumors or cancer of the RECTUM.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

Inhibitory effects of transforming growth factor-beta1 pretreatment on experimental pulmonary metastasis of MCS-1 Chinese hamster mesenchymal chondrosarcoma cells. (1/35)

Recent studies have suggested that transforming growth factor(TGF)-beta1 acts as a multifunctional regulator of cell growth, and also modifies tumor progression and metastasis. In the present study, we investigated the effects of TGF-beta1 on the proliferation and experimental pulmonary metastasis of MCS-1. MCS-1 are undifferentiated type cloned tumor cells established from a mesenchymal chondrosarcoma which spontaneously occurred in the soft tissue of a female Chinese hamster. MCS-1 cells were pretreated with TGF-beta1 (0, 0.05, 0.5, 2, 10 ng/ml) for 72 hours in a medium containing 1% fetal bovine serum, then tested for in vitro growth by the MTT method, in vivo growth by subcutaneous inoculation into athymic nude mice (1 x 10(6) cells/mouse) and experimental pulmonary metastasis by injection into the lateral tail vein of athymic nude mice (5 x 10(4) cells/mouse). TGF-beta1 significantly inhibited in vitro growth of MCS-1, depending on its concentrations, and also experimental metastasis with maximal inhibition at 0.5 or 2 ng/ml treatment compared to untreated controls. TGF-beta1, however, was ineffective for in vivo subcutaneous growth of MCS-1. These results indicated that TGF-beta1 might be an inhibitor of metastasis of mesenchymal chondrosarcomas including other types of non-epitherial cartilage or bone formation tumors.  (+info)

Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. (2/35)

Mesenchymal chondrosarcomas are small-cell malignancies named as chondrosarcomas due to the focal appearance of cartilage islands. In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms. We were able to trace all steps of chondrogenesis within mesenchymal chondrosarcoma by using characteristic marker genes of chondrocytic development. Starting from undifferentiated cells, which were negative for vimentin and any other mesenchymal marker, a substantial portion of the cellular (undifferentiated) tumor areas showed a chondroprogenitor phenotype with an onset of expression of vimentin and collagen type IIA. Cells in the chondroid areas showed the full expression panel of mature chondrocytes including type X collagen indicating focal hypertrophic differentiation of the neoplastic chondrocytes. Finally, evidence was found for transdifferentiation of the neoplastic chondrocytes to osteoblast-like cells in areas of neoplastic bone formation. These results establish mesenchymal chondrosarcoma as the very neoplasm of differentiating premesenchymal chondroprogenitor cells. The potential of neoplastic bone formation in mesenchymal chondrosarcoma introduces a new concept of neoplastic (chondrocytic) osteogenesis in musculoskeletal malignant neoplasms, which qualifies the old dogma that neoplastic bone/osteoid formation automatically implies the diagnosis of osteosarcoma.  (+info)

Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (3/35)

The level of prostaglandin D synthase (PGDS), a major protein constituent of cerebrospinal fluid (CSF), is altered in various brain diseases, including meningitis. However, its role in the brain remains unclear. PGDS is mainly synthesized in the arachnoid cells, the choroid plexus and oligodendrocytes in the central nervous system. Among brain tumors, meningiomas showed intense immunoreactivity to PGDS in the perinuclear region. Thus, PGDS has been considered a specific cell marker of meningioma. In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%). Except for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PGDS. Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. These findings suggest that meningeal HPCs may have a unique molecular phenotype that is distinct from that of the soft-tissue HPCs. The origin of meningeal HPCs may be more closely related to the arachnoid cells.  (+info)

Chondrosarcoma of bone: an oncological and functional follow-up study. (4/35)

We retrospectively analysed the course of 42 out of 45 patients suffering from different chondrosarcomas which were treated surgically. We found a prospective 5- and 10-year survival of 64% for both time intervals. Follow-up examination was possible in 21 of 45 patients. Most of them were staged as NED, one as AWD, and 8 of 45 were lost to follow-up. From 16 dead patients 12 died of the disease and 4 of unknown but not to tumor related reasons. Survival was depending significantly on the histopathological grade, and the stage according to Enneking's surgical staging system. Eleven out of forty-five patients developed metastases within a mean period of twelve months after surgery. The survival of these patients was significantly reduced. Patients with centrally located tumors exhibited a distinct but non-significant worse survival than those suffering from peripheral tumors. In 18% (8 of 45) recurrence of the tumor was evident within a mean period of 24 months (5-85). Functional evaluation was performed in 21 out of 28 alive patients. After a mean follow-up time of 72 months the mean score was 64% (23-100). Females exhibited a distinct but non-significant better result, the same was observed for peripheral locations compared to centrally located tumors. Regarding age, grade, and line of resection no tendency of any dependence was detected, but worst results were seen in those with a stage III tumor and dedifferentiated CS.  (+info)

Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. (5/35)

Cytogenetic studies of mesenchymal chondrosarcoma are few and to date, no specific or recurrent aberrations have been found. In this investigation, the cytogenetic and molecular cytogenetic (spectral karyotypic and fluorescence in situ hybridization) findings for two mesenchymal chondrosarcomas, one arising skeletally and the other extraskeletally, are reported. An identical Robertsonian translocation involving chromosomes 13 and 21 [der(13;21)(q10;q10)] was detected in both cases, possibly representing a characteristic rearrangement for this histopathologic entity. Both cases also exhibited loss of all or a portion of chromosomes 8 and 20 and gain of all or a portion of chromosome 12. The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms.  (+info)

Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. (6/35)

A young adult female Mastiff dog developed a large retroperitoneal mass, pleural effusion, and multiple pulmonary and pleural nodules. All masses were diagnosed as mesenchymal subtype chondrosarcomas, using histological and immunohistochemical criteria. Reports of canine extraskeletal mesenchymal chondrosarcomas (EMCs) are rare but involved animals less than 3 years of age in 60% of the cases. This is the first description of this type of tumor developing distant metastases. Evidence from this case and previous reports suggests that EMCs are associated with a poor prognosis.  (+info)

Mesenchymal chondrosarcoma originating from the femoral vein. (7/35)

Mesenchymal chondrosarcoma is a rare variant of chondrosarcomas characterized by a bimorphic pattern with areas of the undifferentiated malignant small cells and well differentiated cartilaginous islands.(1) It occurs most commonly in the bone but can also occur in the extraskeletal soft tissues, the brain, and the meninges. This type of tumor has also been described in the eyelids, parapharyngeal space, mediastinum, and the kidney.(1-5) An origin from the large vessels has not been reported in the medical literature. The authors report a case of mesenchymal chondrosarcoma originating from the femoral vein in a 28-year-old female patient, treated by the wide-margin resection.  (+info)

Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. (8/35)

BACKGROUND: Mesenchymal chondrosarcoma (MC) is an infrequent neoplasm, representing approximately 1% of all chondrosarcomas. Cytologic descriptions of MCs have been confined to rare case reports. In the current report, the authors describe their experience with the cytologic features of four MCs: two primary tumors and two metastatic lesions. METHODS: Four patients were diagnosed with MC at the authors' institution from 1994 to 2002. Three of four patients underwent fine-needle aspiration (FNA) biopsy as part of their diagnosis; in the fourth patient, imprint cytology was performed. Each tumor also received histologic confirmation. RESULTS: The patients studied included three females and one male. In three patients, the tumor presented initially as a soft tissue mass; whereas, in the remaining patient, the MC presented in the tibia. FNA results demonstrated small, oval-to-spindled cells with high nuclear-to-cytoplasmic ratios. Cells occurred singly and in clumps in a background of basophilic extracellular matrix. Histologic examination of each lesion demonstrated biphasic tumors, including focal areas of relatively mature cartilage formation as well as a small cell population. CONCLUSIONS: MC is a rare soft tissue tumor that occurs frequently in extraskeletal locations. FNA of these tumors can be diagnostic if the tumor is sampled appropriately and of critical features, such as the background extracellular matrix, are recognized. Given the propensity of these tumors to metastasize and the poor prognosis of patients with MC, early identification by FNA biopsy may allow earlier, more aggressive interventions.  (+info)

TY - JOUR. T1 - Intracranial extraskeletal mesenchymal chondrosarcoma. T2 - Case report. AU - Bingaman, Kimberly D.. AU - Alleyne, Cargill H.. AU - Olson, Jeffrey J.. PY - 2000/1. Y1 - 2000/1. N2 - OBJECTIVE AND IMPORTANCE: We present a patient with a dural-based intracranial extraskeletal mesenchymal chondrosarcoma, which was initially thought to be an atypical meningioma. This rare tumor should be considered in the differential diagnosis of young adults with an aggressive-appearing dural-based lesion. CLINICAL PRESENTATION: A 21-year-old woman reported a 3- week history of severe headaches and intermittent nausea and vomiting. Neurological examination revealed right optic nerve swelling. Magnetic resonance imaging demonstrated a large, intensely enhancing extra-axial mass, which appeared to originate from the right side of the falx cerebri with significant mass effect. A presumptive diagnosis of meningioma was made. INTERVENTION: The patient underwent preoperative embolization of the lesion ...
We should be careful in open reduction and internal fixation of fracture and also should consider in mind the diagnosis of pseudoaneurysm during plate removal,
We report on a patient who presented with swelling to the left side of the face accompanied by exophthalmos. Imaging studies revealed a large
However, differential diagnosis may be problematic at early stages with other ossified lesions of soft tissues: benign lesions such as myositis ossificans circumscripta (MOC), ossifying lipoma, soft tissue osteoma or chondroma, and ossifying fibromyxoid tumour, as well as malignant lesions such as classical high-grade ESOS, parosteal OS, mesenchymal chondrosarcoma, and synovial sarcoma. MOC is a benign heterotopic ossification of soft tissues characteristically associated with direct trauma [15]. It is one of the most important differential diagnoses, which was initially evoked - based on radiological and/or pathological aspects - in at least 3 out of the 7 reported cases of low-grade ESOS. Furthermore, a number of cases of ESOS presumably arising from MOC have been reported [16-19]. In MOC, both mature and immature bone is seen, as well as a prominent spindle cell and chondroid component, with a specific architecture described as the zonal phenomenon. This phenomenon refers to the presence of ...
Alvin Deguzman, long-time bassist of The Icarus Line, has died. He had been battling a rare form of cancer (mesenchymal chondrosarcoma), and finally lost the fight a few hours ago. As someone who has met him several times over the years, I am genuinely saddened by his passing. He was a cool dude. May you […]. ...
Ewing sarcoma shows considerable histologic overlap with other round cell tumors. NKX2-2, a homeodomain transcription factor involved in neuroendocrine/glial differentiation and a downstream target of EWSR1-FLI1, has been reported as an immunohistochemical marker for Ewing sarcoma. We assessed the specificity of NKX2-2 for Ewing sarcoma compared with other round cell malignant neoplasms and other soft tissue tumors with EWSR1 translocations. We evaluated whole-tissue sections from 270 cases: 40 Ewing sarcomas (4 with atypical/large cell features), 20 CIC-DUX4 sarcomas, 5 BCOR-CCNB3 sarcomas, 9 unclassified round cell sarcomas, 10 poorly differentiated synovial sarcomas, 10 lymphoblastic lymphomas, 10 alveolar rhabdomyosarcomas, 10 embryonal rhabdomyosarcomas, 10 Merkel cell carcinomas, 10 small cell carcinomas, 20 melanomas, 5 NUT midline carcinomas, 10 Wilms tumors, 10 neuroblastomas, 10 olfactory neuroblastomas, 12 mesenchymal chondrosarcomas, 10 angiomatoid fibrous histiocytomas, 10 clear ...
55 year old male with dedifferentiated chondrosarcoma and pathological fracture. Final Diagnosis: Left proximal femur and soft tissues, en bloc excision: Dedifferentiated chondrosarcoma High grade, grade 3/3 Maximum size 14.6 cm Tumor is ba...
Bone: Dedifferentiated chondrosarcoma, Authors: Andreas F Mavrogenis, Panayiotis J Papagelopoulos. Published in: Atlas Genet Cytogenet Oncol Haematol.
As for the genetics and causes of the cancer, it has been rather hard to find sources which can determine the cause of it, from the website…. The genetic changes specific to chondrosarcoma continue to be investigated extensively. Although studies have not yet established a specific or recurrent karyotypic feature for any of these tumors, different chondrosarcomas have demonstrated anomalies in several tumor suppressor genes, oncogenes, and transcription factors, including TP53, RAS, EXT1, EXT2, and Sox9. Available cytogenetic and comparative genomic hybridization (CGH) studies reveal changes in some chondrosarcomas, but fail to do so in others. These studies are thus far difficult to interpret.. Based on the available studies, it is likely that chondrosarcomas are generated by a coordinated, multi-step process involving primarily tumor suppressor genes. In fact, the complexity and variety of genetic changes seen in chondrosarcomas may indicate several distinct genetic pathways. Some of the ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and chondrosarcoma cells. This suggests there are NF-kappaB dependent mechanisms of cartilage ...
Chondrosarcomas are a primitive malignant tumor that derives from cartilage cells. It usually appears at the center of a bone segment, with no pre-existing lesions (central chondrosarcoma). It may also be secondary to a pre-existent condition suc...
Purpose: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents. We sought to identify critical signaling pathways that contribute to their survival and proliferation, and which may provide potential targets for rational therapeutic interventions. Experimental Design: Activation of receptor tyrosine kinases (RTKs) was surveyed using phospho-RTK arrays. S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. Small interfering RNA or small molecule inhibitors against RTKs or downstream signaling proteins were applied to chondrosarcoma cells and changes in biochemical signaling, cell cycle, and cell viability were determined. In vivo anti-tumor activity of BEZ235, a phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor, was evaluated in a chondrosarcoma xenograft model. Results: Several RTKs were identified as critical mediators of cell growth, but the RTK dependencies varied among cell lines. In ...
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
TY - JOUR. T1 - Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma patient. T2 - A shared antigen of immunoresponses in cancer and autoimmune diseases. AU - Fujiwara, Kazuo. AU - Udono, Heiichiro. AU - Kunisada, Toshiyuki. AU - Kawai, Akira. AU - Inoue, Hajime. AU - Takigawa, Masaharu. AU - Namba, Masayoshi. AU - Nakayama, Eiichi. PY - 1999. Y1 - 1999. N2 - We investigated whether antibodies specific to autologous cancer cells are produced in the peripheral blood of patients with chondrosarcoma. There have been few reports on the investigation of the immune responses, such as autologous antibody production, to chondrosarcoma. Here, tumor-associated antigens were separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and detected by immunoenzymatic amplification. A 56 kDa molecule (M56) was detected in the serum from patients peripheral blood. M56 is ubiquitously expressed in various kinds of ...
Chondrosarcomas are characteristic for their slow but progressive invasion of the surrounding tissues. These malignant, cancerous tumors originate in the cartilage, the connective tissue between bones.
Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla. show less ...
Learn about the rare cancer Chondrosarcoma, its symptoms, causes, diagnosis methods, and treatment options available to overcome the problem.
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine.
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine.
Chondrosarcoma treatments include chemotherapy, radiation therapy, targeted therapies, and surgery, to remove the mass and reduce the likelihood of return.
Kevin B. Jones, MD of University of Utah - Huntsman Cancer Institute receives grant for Polarity and Ploidy in Peripheral Chondrosarcoma research.
Learn more about Chondrosarcoma at Coliseum Health System DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision .....
No. of Printed Pages : 3 MCA (Revised) MCS-012 Term-End Examination tr) June, 2011 cNI 0 ,--. MCS-012 : COMPUTER ORGANISATION & ASSEMBLY LANGUAGE
AIMS: Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumours. METHODS AND RESULTS: We evaluated 240 cases (133 in whole-tissue sections; 107 in tissue microarrays), including 76 peripheral neuroblastic tumours (median age 2 years; including four adults) and 164 other tumours: 44 Wilms tumours; 20 Ewing sarcomas; 10 each of CIC-rearranged round cell sarcomas, poorly differentiated synovial sarcomas, lymphoblastic lymphomas, alveolar rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal chondrosarcomas, Merkel cell carcinomas, olfactory neuroblastomas, and melanomas; and five each of NUT midline carcinomas and desmoplastic small round cell tumours ...
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of αvβ3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated that IL-8 enhances the migration of chondrosarcoma cells by increasing αvβ3 integrin ...
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. To achieve a greater understanding of chondrosarcoma tumorigenesis, a model for human chondrosarcoma has been established in a rat system. The model, known as the Swarm rat chondrosarcoma (SRC), resembles human chondrosarcoma and provides a system to study tumor growth and progression. Here we examined the influence of the tumor microenvironment and the impact of genome-wide hypomethylation on the behavior of SRC tumors, two factors known to contribute fundamentally to the development and progression of solid tumors. Previous studies with SRC revealed that tumor microenvironment can significantly influence chondrosarcoma malignancy, but the underlying biologic mechanisms have not been defined. To address this issue we carried out epigenetic and gene expression studies on the SRC tumors that were initiated at
TY - JOUR. T1 - Chondrosarcoma. T2 - Its treatment by radiation, hyperthermia and bleomycin. AU - Okuyama, S.. AU - Itoh, M.. AU - Tanaka, K.. AU - Matsuzawa, T.. PY - 1978/12/1. Y1 - 1978/12/1. N2 - A case of chondrosarcoma of the mandible of surgical failure was treated by radiation, hyperthermia, and bleomycin. The treatment resulted in selective necrosis of the tumor. This can be designated as perpetuation principle of radiothermotherapy because bleomycin may inhibit the repair processes of heat and radiation damage. This principle appears to offer selectivity of the therapeutic effects, to open a way to treatment of those radioresistant selectivity of the therapeutic effects, open a way to treatment of those radioresistant malignancies, and to enhance curability of various medium-sensitive tumors. Additionally, a course of large-dose glutathione infusion was confirmed to promptly alleviate radiation dermatitis and mucositis.. AB - A case of chondrosarcoma of the mandible of surgical failure ...
Imaging studies - including radiographs (x-rays), computerized tomography (CT), and magnetic resonance imaging (MRI) - are often used to make a presumptive diagnosis of chondrosarcoma. However, a definitive diagnosis depends on the identification of malignant cancer cells producing cartilage in a biopsy specimen that has been examined by a pathologist. In a few cases, usually of highly anaplastic tumors, immunohistochemistry (IHC)is required.. There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma. The most characteristic imaging findings are usually obtained with CT.. Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there is a noticeable lump or pain. Earlier diagnosis is generally accidental, when a patient undergoes testing for another problem and physicians discover the cancer. Occasionally the first symptom will be a broken bone at the cancerous site. Any broken ...
Get information, facts, and pictures about Chondrosarcoma at Encyclopedia.com. Make research projects and school reports about Chondrosarcoma easy with credible articles from our FREE, online encyclopedia and dictionary.
We report an unusual case of a young woman with chondrosarcoma affecting the greater cornu of the hyoid bone. Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. The case described presented as a swe
TY - JOUR. T1 - An extraskeletal chondrosarcoma of the maxilla. A case report. AU - Nishioka, Gary. AU - Holt, G. Richard. AU - Aufdemorte, Thomas B.. AU - Triplett, Robert G.. PY - 1995/2. Y1 - 1995/2. UR - http://www.scopus.com/inward/record.url?scp=0028858834&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028858834&partnerID=8YFLogxK. U2 - 10.1016/0278-2391(95)90401-8. DO - 10.1016/0278-2391(95)90401-8. M3 - Article. C2 - 7830187. AN - SCOPUS:0028858834. VL - 53. SP - 193. EP - 195. JO - Journal of Oral and Maxillofacial Surgery. JF - Journal of Oral and Maxillofacial Surgery. SN - 0278-2391. IS - 2. ER - ...
Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum, resection may be performed in an appropriate surgical candidate based on imaging characteristics or image-guided percutaneous biopsy results; incisional biopsy is rarely required. The keys to successful treatment are early recognition and radical excision with adequate margins, as chondrosarcoma is relatively resistant to radiotherapy and conventional cytotoxic chemotherapy. Overall survival is excellent in most surgical series from experienced centers. Complete excision with widely negative microscopic margins at the initial operation is of the utmost importance, as local recurrence portends systemic metastasis and eventual tumor-related mortality. This
A chondrosarcoma in the anterior mediastinum is a rare finding with a relatively good prognosis. We describe a case of a 75-year-old man with a 2-year history of neck discomfort and weight loss. Imaging showed a homogenous tumor with a minor compression on the anterior part of the heart. It had close relation to the ribs, no surrounding fat, and a thymoma was suspected. Biopsy prior to surgery was impossible due to the location of the tumor. Unfortunately, final pathology from the surgical specimen revealed a chondrosarcoma. ...
Depending on the type of chondrosarcoma, it may spread slowly or very rapidly. Its presently unknown what causes this type of cancer. This is partially because it is so unusual that there are not a lot of cases to study. A higher incidence of nasal CSAs among cats living in urban areas may indicate a link to air pollution. The type affecting bones has been found to contain viruses in the cells of the tumor, suggesting a viral connection. Some bone tumors develop on the site of a previous fracture, which may mean theres a link with the bodys cells that heal a broken bone. But its believed that several factors combine with each unique cats physiology to cause the cells to become cancerous ...
A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. This is a relatively rare and fast spreading tumor that originates in the cartilage, a connective collagenous tissue that is found throughout the body.
The following are treatment options for all stages of chondrosarcoma. The types of treatments given are based on the unique needs of the person with cancer.
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Pain is the usual presenting symptom; alternatively the tumour may be found incidentally on imaging. Signs are localise to the involved bone. Imaging appearances are difficult as most chondrosarcomas resemble benign chondroma. The most common features are of central lucency with expansion and thickening of the overlying cortex.. ...
These deficits are summarized in Display 10-17, the lesions are charac- terized by a bimorphic pattern that is composed of highly undifferentiated small round cells and islands of well- differentiated hyaline cartilage. Judicial procedures It is exaemn established that governing body disciplinary procedures Propranolo subject to the propranтlol of natural justice. L.
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
Axial T2 weighted MR image again demonstrates the mass with typical high signal lobular growth pattern of cartilage representing cap.
When I was diagnosed with ovarian cancer, the first reaction was of course panic, and then I Packed up and started to look for information on the Internet and on the forums. Im still grateful to all those people who write reviews about their appeal to different professionals - I this information helped to survive. That is why I write about how I got to Israel, and how I was able to overcome the disease.The purpose of my search information on the Internet to understand where and how to treat ovarian cancer, what are my prospects in General? The important thing is that I knew we must act quickly. Of course, I wanted to go to a top specialist because of the ability to experiment just wasnt there.I immediately realized that I wanted to be treated in Israel, as there is a percentage of cure from cancer is very high, including ovarian cancer. This treatment is cheaper than, say, the USA or Germany, for me it was also an important argument. I only had to choose the doctor. About Professor Moshe Inbar ...
The actuarial 5- and 10-year survival rates after GKS were 80 and 53%, respectively. The actuarial 5- and 10-year local tumor control (LTC) rates after single or multiple GKS sessions were 76 and 67%, respectively. All patients with low-grade chondrosarcomas achieved good LTC. A tumor volume of less than 20 ml significantly affected the high rate of LTC (p = 0.0182). No patient had adverse radiation effects, other than one in whom facial numbness worsened despite successful tumor control. ...
The actuarial 5- and 10-year survival rates after GKS were 80 and 53%, respectively. The actuarial 5- and 10-year local tumor control (LTC) rates after single or multiple GKS sessions were 76 and 67%, respectively. All patients with low-grade chondrosarcomas achieved good LTC. A tumor volume of less than 20 ml significantly affected the high rate of LTC (p = 0.0182). No patient had adverse radiation effects, other than one in whom facial numbness worsened despite successful tumor control. ...
MSH: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed),NCI: A type of cancer that forms in bone cartilage. It usually starts in the pelvis (between the hip bones), the shoulder, the ribs, or at the ends of the long bones of the arms and legs. A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. Instead, it forms in the soft tissues of the upper part of the arms and legs. Chondrosarcoma can occur at any age but is more common in people older than 40 years. It is a type of bone cancer.,NCI: A malignant mesenchymal neoplasm arising from cartilage-forming tissues.,NCI: A malignant tumor with pure hyaline cartilage differentiation. Myxoid changes, calcification and ossification ...
Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance do not reliably predict the risk of local recurrence and metastases, making selection of surgical treatment difficult. Identifying mechanisms responsible for the proliferation and invasive behavior of these tumors would be of immense clinical value. We hypothesized that telomerase expression is one of these mechanisms. We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas acquired strong telomerase activity and lost tumor suppressor activity after their establishment in culture. These changes were associated with accelerated indefinite cell proliferation, morphological transition, and increased invasive activity, indicating that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from chondrosarcoma cell populations. These observations may lead to better ...
The study, Lost miRNA surveillance of Notch, IGFR pathway - road to sarcomagenesis, was published in the January issue of Tumor Biology, the official journal of the International Society of Oncology and BioMarkers. Sarcomas are a group that makes up more than 60 different tumors that affect bone and connective tissues. Chondrosarcomas are the second most common bone malignancy and do not respond to conventional therapy. Together with H. Thomas Temple, M.D., professor and Vice Chair of Orthopedics and Director of the Tissue Bank, who in 2010 established the Musculoskeletal Oncology Signal Transduction Laboratory to investigate the molecular pathways leading to metastatic sarcomas, Galoian and her team compared and analyzed differentially expressed miRNA and their targets in chondrosarcoma versus control chondrocytes. Under normal conditions, mesenchymal cells support and produce a matrix for connective tissues; however, the signaling events resulting in mesenchymal cell transformation to ...
Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. We report the case of a 68-year-old man with chondrosarcoma in the subglottic area. His chief symptoms were hoarseness and mild dysphagi
Chondroid tumors are predominantly lesions of the axial skeleton but can infrequently have an extraskeletal origin. Primary intracranial chondrosarcomas constitute ,0.16% of all brain tumors, an overwhelming majority of which are skull base tumors (1, 2). They are thought to arise from undifferentiated cells from cartilaginous synchondroses (1-3, 6, 7). Much less common sites include the falx, choroid plexus, and convexity. The histogenesis at this site is uncertain but is thought to arise from the pluripotent cells of the meninges.. Primary chondrosarcomas can be classified as mesenchymal, myxoid, or classical based on their cytoarchitecture. In the series published by Korten et al (2), which included 15 case reports plus 177 cases from a review of the literature, no sex dominance was shown. Ages varied from 3 months to 76 years, with a mean age of 37 years. Considering the rarity of occurrence of intracranial chondrosarcomas, it was difficult to establish a clear demographic pattern; however, ...
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that over-expression of COX-2 or exogenous PGE2 increased the migration of human chondrosarcoma cells. We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was higher than that in normal cartilage. By using pharmacological inhibitors or activators or genetic inhibition by the EP receptors, we discovered that the EP1 receptor but not other PGE receptors is involved in PGE2-mediated cell migration and α2β1 integrin expression. Furthermore, we found that human
BioAssay record AID 79237 submitted by ChEMBL: In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay.
Marco wants to wait at least 8 weeks to let everything heal up and also allow us time to decide where to go from here. My initial feelings lean toward the complete knee replacement. The other concern is of the cancer spreading to the lungs. I had a c.t. scan before surgery that revealed no tumors in the lungs. However, the cancer is slow-growing so it could already be there and just not visible. I will continually have c.t. scans to check That is our update. Please continue to pray for Jenny as she is due with our second baby in less than 1 month. Also pray for Zeke as he is in the difficult transition from only child to soon to be little brother (which is only complicated with all the added stress of my medical conditions ...
(2009) Kim et al. Molecular Cancer. Background: High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied i...
IRDA]: mcs7780 needs to free allocated rx buffer. While testing the mcs7780 based IrDA USB dongle Ive stumbled upon memory leak in mcs_net_close(). Patch below fixes it. Signed-off-by: Hinko Kocevar ,[EMAIL PROTECTED], Signed-off-by: Samuel Ortiz ,[EMAIL PROTECTED], Signed-off-by: David S. Miller ,[EMAIL PROTECTED], --- drivers/net/irda/mcs7780.c , 2 ++ 1 files changed, 2 insertions(+), 0 deletions(-) diff --git a/drivers/net/irda/mcs7780.c b/drivers/net/irda/mcs7780.c index 0b76919..93916cf 100644 --- a/drivers/net/irda/mcs7780.c +++ b/drivers/net/irda/mcs7780.c @@ -677,6 +677,8 @@ static int mcs_net_close(struct net_device *netdev) /* Stop transmit processing */ netif_stop_queue(netdev); + kfree_skb(mcs-,rx_buff.skb); + /* kill and free the receive and transmit URBs */ usb_kill_urb(mcs-,rx_urb); usb_free_urb(mcs-,rx_urb); - To unsubscribe from this list: send the line unsubscribe git-commits-head in the body of a message to [EMAIL PROTECTED] More majordomo info at ...
Chondrosarcoma of the pelvis and upper end of the femur. An analysis of factors influencing survival time in one hundred and thirteen cases. Journal of Bone and Joint Surgery - American Volume. 1972 ...
For the past two years, there has been a growing concern over the safety of the manmade chemical known as C-8 or PFOA (perfluorooctanoic acid) which can be
Miller was diagnosed with mesenchymal chondrosarcoma, a form of bone cancer, in 2008, the same year that With Arrows, With ...
... chondrosarcoma MeSH C04.557.450.565.280.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.565.380 - giant cell tumors MeSH ... chondrosarcoma MeSH C04.557.450.795.300.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.795.350 - fibrosarcoma MeSH C04.557. ...
... the more common fetal and embryonal types do not Merkel cell carcinoma Mesenchymal chondrosarcoma Endometrial stromal ...
Myxoid chondrosarcoma M9240/3 Mesenchymal chondrosarcoma M9241/0 Chondromyxoid fibroma M9242/3 Clear cell chondrosarcoma M9243/ ... NOS Mixed mesenchymal tumor M8990/3 Mesenchymoma, malignant Mixed mesenchymal sarcoma M8991/3 Embryonal sarcoma M9000/0 Brenner ... M9221/0 Juxtacortical chondroma Periosteal chondroma M9221/3 Juxtacortical chondrosarcoma Periosteal chondrosarcoma M9230/0 ... 3 Dedifferentiated chondrosarcoma M9250/1 giant cell tumor of bone, NOS Osteoclastoma, NOS M9250/3 Giant cell tumor of bone, ...
Yang J, Ren Z, Du X, Hao M, Zhou W (27 October 2014). "The role of mesenchymal stem/progenitor cells in sarcoma: update and ... Some sarcomas, such as leiomyosarcoma, chondrosarcoma, and gastrointestinal stromal tumor (GIST), are more common in adults ... A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. ... These subtypes are as follows: Osteosarcoma Chondrosarcoma Poorly differentiated round/spindle cell tumors (includes Ewing ...
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... As suggested in the name, mesenchymal progenitors originate from the mesoderm. These cells, when forming from the mesoderm, ... Day, Timothy F.; Guo, Xizhi; Garrett-Beal, Lisa; Yang, Yingzi (2005). "Wnt/β-Catenin Signaling in Mesenchymal Progenitors ... Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ...
IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal ... CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma : Cancerbackup". Archived from the original on 2008- ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Media related to Chondrosarcoma at ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ...
... (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ... "Myxoid Chondrosarcoma - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-02-04. Rubin, Brian P.; ... Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. OCLC ... when they discussed the different species of extraskeletal chondrosarcoma, but EMC concept was firstly proposed in 1972 by ...
Chondrosarcoma *Mesenchymal chondrosarcoma. *Myxoid chondrosarcoma. *Osteochondroma *Osteochondromatosis. *Chondromyxoid ...
... mesenchymal cells. There are some who think it is a myoepithelial tumor type. Derived from ectomesenchymal cells migrating from ... extraskeletal myxoid chondrosarcoma, focal oral mucinosis, and an ossifying fibromyxoid tumor of soft parts. Exceedingly rare, ...
... chondrosarcoma - chordoma - chorioallantoic membrane - choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic ... mesenchymal - mesenteric membrane - mesna - mesonephroma - mesothelioma - metaplasia - metaplastic carcinoma - metastasectomy ...
... (RMS), is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully ... chondrosarcoma, or angiosarcoma". The American Journal of Surgical Pathology. 26 (9): 1175-1183. doi:10.1097/00000478-200209000 ...
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. „J Pathol". ... Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. „Clin Orthop Relat Res". 459, s. 40-7, Jun ... Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.. „Med Sci Monit". 17 (8), s. RA177-190 ...
... each of which develop from cells originating in mesenchymal cells outside the bone marrow. ... Chondrosarcoma. *Ewing's sarcoma. *Malignant fibrous histiocytoma of bone/osteosarcoma. *Osteosarcoma. *Rhabdomyosarcoma. * ...
Mesenchymal chondrosarcoma of the orbit: CT and MRI Findings. Clin Radiol. 2012;67:346-51. CrossRefPubMed ... Mesenchymal chondrosarcoma of the orbit: CT and MRI Findings. Clin Radiol. 2012;67:346-51. CrossRefPubMed Yang BT, Wang YZ, ... Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. Clin Imaging. 2012;36:365-70. CrossRefPubMed ... Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis. Case report and review of the ...
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report. Together they form a unique fingerprint. * Mesenchymal ... Intracranial extraskeletal mesenchymal chondrosarcoma: Case report. Kimberly D. Bingaman, Cargill H. Alleyne, Jeffrey J. Olson ... CONCLUSION: Intracranial mesenchymal chondrosarcoma is a rare neoplasm that can mimic a meningioma radiographically. We present ... CONCLUSION: Intracranial mesenchymal chondrosarcoma is a rare neoplasm that can mimic a meningioma radiographically. We present ...
Overall, mesenchymal chondrosarcomas included less than 10% of all type of chondrosarcomas and often originates from the ... You are at:Home » Sep - Oct 2016 , Volume 6 , Issue 4 » Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare ... Mesenchymal chondrosarcoma of bone and soft tissues. Cancer. 1983;52:533-541.. 4. Seo C, Jung S T, Byun J W. Extraskeletal ... Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. J Hand Surg Am. 2007;32:389-392.. 3. Bertoni F, Picci P ...
... Michael W. Bishop,1,2 ... Mesenchymal chondrosarcoma is an aggressive, uncommon histologic entity arising in bone and soft tissues. We reviewed our ... We conducted a retrospective chart review on patients with mesenchymal chondrosarcoma over a 24-year period. Clinicopathologic ... Aggressive surgical resection of mesenchymal chondrosarcoma with chemoradiotherapy yields excellent local control and may ...
Extraskeletal mesenchymal chondrosarcoma. Radiology 1993;186:819-26. [ Links ]. 13. Aryoshi Y, Shimahara M. Mesenchymal ... It has also been established that mesenchymal chondrosarcoma expresses Sox-9 gene, a regulator in mesenchymal cell ... Mesenchymal chondrosarcoma of the jaws. Oral Surg Oral Md Oral Pathol 1982;54:197-206. [ Links ]. ... Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 1986;57:2444-453. [ Links ]. ...
Identification of the novel HEY1-NCOA2 fusion in the mesenchymal chondrosarcoma case UF5. A, Upper: partial schema of HEY1 and ... RT-PCR detection of the HEY1-NCOA2 fusion in additional mesenchymal chondrosarcoma cases. Upper panel: RT-PCR performed using ... Exon expression plot of NCOA2 in the mesenchymal chondrosarcoma sample UF5, showing the intragenic change in NCOA2 expression. ... Interphase FISH detection of HEY1-NCOA2 fusion in mesenchymal chondrosarcomas. A, the schema of FISH-probe design. B, ...
Khalil and colleagues for their comments [1]. We agree that the discovery of the fusion testing in mesenchymal chondrosarcoma ... Periosteal mesenchymal chondrosarcoma of the tibia. Skeletal Radiol. https://doi.org/10.1007/s00256-018-2885-9. ... It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal ... chondrosarcomas, particularly those with less than optimal pathologic features or sampling. We intend to make use of testing ...
Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a ... Chondrosarcoma (CS) is a malignant tumour of long and flat bone characterised by the formation of cartilage. ...
Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in ... A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed ... Chondrosarcoma, Mesenchymal. Known as: Chondrosarcomas, Mesenchymal, chondrosarcoma mesenchymal, Mesenchymal Chondrosarcoma ( ... Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 ...
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... Mesenchymal chondrosarcoma. The 5-year survival rate for mesenchymal chondrosarcoma is less than 50%, with an overall 10-year ... Fewer than 2% of all chondrosarcomas are mesenchymal chondrosarcomas. The maxilla and the mandible are the most common sites of ... encoded search term (Chondrosarcoma) and Chondrosarcoma What to Read Next on Medscape. Related Conditions and Diseases. * Fast ...
Chondrosarcoma.. References. *↑ Dowling EA (June 1964). "Mesenchymal chondrosarcoma". J Bone Joint Surg Am 46: 747-54. PMID ... Mesenchymal chondrosarcoma is a rare type of chondrosarcoma that is found in the soft tissue. ... Jun 2011). "[Clinicopathologic and immunohistochemical study of 23 cases of mesenchymal chondrosarcoma].". Zhonghua Bing Li Xue ... May 2010). "Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ...
Radiation is used in selected cases, particularly extraskeletal mesenchymal chondrosarcomas. *Wide/Radical limb sparing surgery ... Thank-you so very much for being my surgeon for that chondrosarcoma, for saving my life! And I have learned over the months ( ... Undifferentiated mesenchymal cells similar to Ewing sarcoma. *Low grade islands of cartilage scattered throughout the ...
Mesenchymal chondrosarcoma (MC) is a rare variant of chondrosarcoma (CS) that accounts for upto 3-9% of all CS and has high ... Mesenchymal chondrosarcoma of maxilla : a rare case report. DSpace Repository. Valencià Castellano ... Mesenchymal chondrosarcoma of maxilla : a rare case report. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 ... Mesenchymal chondrosarcoma of maxilla : a rare case report. Show simple item record ...
Extraskeletal mesenchymal chondrosarcoma. Treatment of extraskeletal mesenchymal chondrosarcoma may include the following: * ... Extraskeletal mesenchymal chondrosarcoma . This type of bone and cartilage tumor often affects young adults and occurs in the ... Extraskeletal myxoid chondrosarcoma. Treatment of extraskeletal myxoid chondrosarcoma may include the following:. * Surgery to ... Extraskeletal myxoid chondrosarcoma . This type of soft tissue sarcoma may occur in children and adolescents. Over time, it ...
Mesenchymal Chondrosarcoma of the Chest Wall. Borys, Dariusz; Canter, Robert J. Borys, Dariusz; Canter, Robert J. Less ...
Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to ... Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to ... PRP-1 inhibits mesenchymal tumors. Tumour Biol. 2011;32(4):745-51.PubMedCrossRefGoogle Scholar ... Kinome profiling of chondrosarcoma reveals Src-pathway activity and dasatinib as option for treatment. Cancer Res. 2009;69:6216 ...
Make research projects and school reports about Chondrosarcoma easy with credible articles from our FREE, online encyclopedia ... clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the ... Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. Central chondrosarcoma occurs within a ... Mesenchymal chondrosarcoma is another rare variant. However, as opposed to clear cell chondrosarcoma, it is highly malignant ...
This report studies Global Chondrosarcoma Market, especially in North America, China, Europe, Southeast Asia, Japan and India, ... Conventional Chondrosarcoma. Clear Cell Chondrosarcoma. Myxoid Chondrosarcoma. Mesenchymal Chondrosarcoma. Dedifferentiated ... 1.2.4 Mesenchymal Chondrosarcoma. 1.2.5 Dedifferentiated Chondrosarcoma. 1.2.6 Others. 1.3 Applications of Chondrosarcoma. 1.3. ... 6.3.3 Myxoid Chondrosarcoma of Chondrosarcoma Growth Driving Factor Analysis. 6.3.4 Mesenchymal Chondrosarcoma of ...
IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal ... CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma : Cancerbackup". Archived from the original on 2008- ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Media related to Chondrosarcoma at ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ...
However no such concomitance has been reported with chondrosarcoma. We report the first case of mesenchymal chondrosarcoma ... Immunohistochemical and morphological findings revealed malignant mesenchymal chondrosarcoma. Conclusion: IH is well known to ... results of surgery depending on location or extension to unresectable sites of majority of mesenchymal chondrosarcomas. ... But no such association has been reported with chondrosarcoma. In musculoskeletal masses of patients with hemihyperplasia, the ...
High-Resoultion Images of Extraskeletal Mesenchymal Chondrosarcoma from Sarcoma Images, the Internet Database of Bone and Soft ...
Miller was diagnosed with mesenchymal chondrosarcoma, a form of bone cancer, in 2008, the same year that With Arrows, With ...
Mesenchymal chondrosarcomas mainly occurred in the younger age group (10-30 years). The grade I chondrosarcoma had no clear age ... 1993) Intracranial mesenchymal chondrosarcoma: a case report and literature review. Childs Nerv Syst 9:295-299. ... The more malignant mesenchymal chondrosarcoma had a tendency towards a malign growth pattern which is illustrated by the ... 1990) Mesenchymal chondrosarcoma of the craniocervical junction. Clin Neurol Neurosurg 92:343-347. ...
Mesenchymal chondrosarcoma. * Neurofibroma of bone (schwannoma). * Osteoblastoma. * Pagets disease/pagetoid osteosarcoma. * ...
1. Cartilaginous a. Mesenchymal chondrosarcoma 2. Osseous a. High grade surface osteosarcoma 3. Fibrous and fibrohistiocytic a ...
Mesenchymal (extraskeletal) chondrosarcoma. *Leiomyosarcoma. *Liposarcoma (excluding myxoid liposarcoma). *Undifferentiated ... extraskeletal myxoid chondrosarcoma, neoplasms with perivascular epithelioid cell differentiation (PEComa), intimal sarcoma, ... atypical fibroxanthoma, mixed tumor NOS, phosphaturic mesenchymal tumor, malignant ossifying fibromyxoid tumor, malignant mixed ...
Mesenchymal chondrosarcoma: a series of 23 cases. Jambhekar, Nirmala A; Desai, Saral S; Aggarwal, Manish G; Puri, Ajay; ... A total of 23 cases of mesenchymal chondrosarcoma were studied from the histopathology records spanning 23 years. There were 16 ... Osseous and extra-osseous mesenchymal chondrosarcomas are compared and the differential diagnosis discussed. ... Adolescent , Adult , Bone Neoplasms/pathology , Child , Child, Preschool , Chondrosarcoma/pathology , Chondrosarcoma, ...
Histologically, mesenchymal chondrosarcomas are characterized by a mix of cartilage and undifferentiated stromal tissue. ... We present a case of mesenchymal chondrosarcoma presenting as chronic sinusitis, arising in the sinonasal cavity. Additionally ... Radiographically, they demonstrate features similar to the more commonly encountered conventional chondrosarcoma, with the ... Mesenchymal chondrosarcoma is a rare, highly malignant cartilaginous forming tumor that is rarely encountered in clinical ...
The following are treatment options for all stages of chondrosarcoma. The types of treatments given are based on the unique ... Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. It may be treated with the following ... If mesenchymal chondrosarcoma has already spread (metastasized) at the time of the diagnosis, the following drug combination ... It is the most common type of surgery used for chondrosarcoma. It is used to treat a chondrosarcoma in the bones of the skull ...
  • Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. (semanticscholar.org)
  • Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
  • PRP-1 inhibits mesenchymal tumors. (springer.com)
  • Due to the location of chondrosarcoma tumors, the result is often a decrease in the range of motion of limbs, especially tumors occurring on the epiphysis of bones such as those seen in clear cell chondrosarcoma. (encyclopedia.com)
  • However, researchers have discovered that chondrosarcomas are sometimes associated with underlying benign bone tumors. (encyclopedia.com)
  • A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. (wikipedia.org)
  • Peripheral de-differentiated chondrosarcomas are among the rarest malignant mesenchymal tumors. (hindawi.com)
  • This investigation surveyed imaging of peripheral de-differentiated chondrosarcomas to facilitate better recognition of these uncommon tumors. (hindawi.com)
  • Chondrosarcoma represents a heterogeneous group of cartilage-forming tumors. (aacrjournals.org)
  • These tumors are treated by en bloc resection. (aacrjournals.org)
  • Saglik, "Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients," Journal of Orthopaedic Science, vol. (thefreedictionary.com)
  • Background: Sarcomas are rare tumors (1-2% of all cancers) of mesenchymal origin that may develop in soft tissues and viscera. (ebscohost.com)
  • Analyzes the clinicoradiographic, microscopic and immunophenotypic features of 21 tumors from 13 patients with mesenchymal chondrosarcoma neoplasms. (ebscohost.com)
  • FAS-positive sarcomas were found in 13 of 23 malignant fibrous histiocytomas, 3 of 17 liposarcomas, 3 of 7 malignant peripheral nerve sheath tumors, and 1 extraskeletal mesenchymal chondrosarcoma. (aacrjournals.org)
  • The gene was originally identified because of its amplification in a human glioblastoma, and previous studies have shown it to be amplified in a significant proportion of mesenchymal tumors, such as childhood sarcomas. (aacrjournals.org)
  • Samples from 40 patients (37 sarcomas and 3 benign mesen chymal tumors) and samples of 15 normal mesenchymal tissues were examined for GLI gene amplification and expression by Southern hybridization, reverse transcription-PCR of tissue RNA, and immunohisto- chemistry, using a new polyclonal GLI antibody developed against an epitope outside of the zinc finger region. (aacrjournals.org)
  • The complete WHO classification of SN tumors can be found online at http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb9/index.php. (appliedradiology.com)
  • We report the first case of mesenchymal chondrosarcoma presenting with isolated hemihypertrophy. (jocr.co.in)
  • We report a case of mesenchymal chondrosarcoma arising from the left ankle region of a patient with isolated hemihypertrophy of right side of her body. (jocr.co.in)
  • We present a case of mesenchymal chondrosarcoma presenting as chronic sinusitis, arising in the sinonasal cavity. (wright.edu)
  • We describe a rare case of mesenchymal chondrosarcoma of the thyroid gland with uncertain primary origin. (biomedcentral.com)
  • We report another case of mesenchymal chondrosarcoma of the kidney with synchronous implant and a coexistent infiltrating urothelial carcinoma of the ureter firstly. (biomedcentral.com)
  • Histopathological examination and immunohistochemical studuies showed the classic features of mesenchymal chondrosarcoma in kidney, as well as a few infiltrating urothelial in ureter. (biomedcentral.com)
  • However, the amount of these spindled cells is small and not all the classic features of mesenchymal chondrosarcoma are seen on histology. (radiopaedia.org)
  • Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. (nih.gov)
  • Aggressive surgical resection of mesenchymal chondrosarcoma with chemoradiotherapy yields excellent local control and may reduce likelihood of late recurrence. (hindawi.com)
  • Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. (bmj.com)
  • Extraskeletal chondrosarcomas (EMC) is a rare aggressive neoplasm which has been seen in the soft tissue area. (jocr.co.in)
  • In type 1, the radiographic appearance is the same as for a central chondrosarcoma, with the addition of a region with very aggressive bone destruction. (atlasgeneticsoncology.org)
  • Two other subtypes with a worse prognosis are dedifferentiated chondrosarcoma, a highly malignant variant ( 4 ), and mesenchymal chondrosarcoma, a rare aggressive subtype in which distant metastasis can be identified even after 20 years ( 5-7 ). (aacrjournals.org)
  • This more aggressive version of chondrosarcoma typically occurs in adolescence and in people over age 60. (sarctrials.org)
  • and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line. (springer.com)
  • Galoian K, Scully S, McNamara G, Flynn P, Galoyan A. Antitumorigenic effect of brain proline rich polypeptide-1 in human chondrosarcoma. (springer.com)
  • However, it is scarcely reported that SDF-1-Gab1 pathway mediates proliferation and apoptosis in human chondrosarcoma (CS). (springer.com)
  • The novel HEY1-NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas. (nih.gov)
  • Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. (librepathology.org)
  • Among the less common are chondrosarcoma, fibrosarcoma , and malignant fibrous histiocytoma , all of which arise from spindle cell neoplasms. (encyclopedia.com)
  • We agree that the discovery of the fusion testing in mesenchymal chondrosarcoma can be helpful in confirming its diagnosis, particularly in difficult cases. (springer.com)
  • It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal chondrosarcomas, particularly those with less than optimal pathologic features or sampling. (springer.com)
  • Imaging studies - including radiographs ("x-rays"), computerized tomography (CT), and magnetic resonance imaging (MRI) - are often used to make a presumptive diagnosis of chondrosarcoma. (wikipedia.org)
  • citation needed] There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma. (wikipedia.org)
  • Osseous and extra-osseous mesenchymal chondrosarcomas are compared and the differential diagnosis discussed. (bvsalud.org)
  • This case highlights the importance of correlating pathologic diagnosis with sonographic findings, the appropriate utilization of fine needle aspiration and core needle biopsy to evaluate thyroid nodules and the rare incidence of mesenchymal chondrosarcoma involving the thyroid. (biomedcentral.com)
  • Carcinosarcoma is a rare type of gallbladder malignancy, the diagnosis requires the presence of both malignant epithelial and mesenchymal components. (ijri.org)
  • Final diagnosis: high-grade chondrosarcoma . (radiopaedia.org)
  • complete wide resection of mesenchymal chondrosarcoma could be enough as an initial treatment and chemotherapy reserved for patients that have unresectable masses. (jocr.co.in)
  • Recent studies have shown that induction of apoptosis in high-grade chondrosarcoma, both directly and by enhancement of response to chemotherapy and radiation, is a valid therapeutic strategy. (wikipedia.org)
  • Chemotherapy is not used for low-grade chondrosarcoma because it has not been shown to help improve survival. (cancer.ca)
  • What's the best chemotherapy protocol for mesenchymal chondrosarcoma stage 1b? (healthtap.com)
  • As a result, some people with grade 3 chondrosarcomas are treated with adjuvant chemotherapy. (sarctrials.org)
  • About 30% of bone sarcomas are chondrosarcomas. (wikipedia.org)
  • Unlike other primary bone sarcomas that mainly affect children and adolescents, a chondrosarcoma can present at any age. (wikipedia.org)
  • Long-term results of phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas. (springer.com)
  • Chondrosarcoma is considered as a common primary bone sarcoma, which is ranked as the third primary bone malignancy One in five cases of bone sarcomas are due to chondrosarcoma , and half of all cases affect the pelvis (1). (thefreedictionary.com)
  • Galoian K, Temple TH, Galoyan A. Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma. (springer.com)
  • It is a subtype of chondrosarcoma, a term that includes a heterogeneous group of lesions with varied clinical behaviour and morphological features that share the common feature arising from ossified cartilage or cartilaginous rests. (scielo.org.za)
  • The mesenchymal subtype has a poor prognosis. (jocr.co.in)
  • Generally, mesenchymal subtype included less than 10% of all types of chondrosarcomas and is more common in the bone [1-3]. (jocr.co.in)
  • Other less common types of bone cancer include: Chondrosarcoma (a cancer arising in cartilage cells, usually found in adults between ages 50-75, though the less common mesenchymal-chondrosarcoma is more frequent in younger patients), Malignant Fibrous Histiocytoma of bone (MFH), Chondoma (a rare low grade malignancy occuring mostly between ages 30 -70), and other rare tumours. (cancerindex.org)
  • Peripheral mineralization with a bimorphic pattern on CT scan and the presence of a soft-tissue mass should be considered worrisome for a peripheral de-differentiated chondrosarcoma, particularly in the setting of multiple hereditary exostoses. (hindawi.com)
  • The rate of dedifferentiation is 13%-15% in central chondrosarcomas compared to 4%-5% in peripheral chondrosarcomas. (atlasgeneticsoncology.org)
  • We report a case of primary mesenchymal chondrosarcoma occurring in the left kidney with an ipsilateral and distinct distal ureteric implant, and a coexisting infiltrating urothelial carcinoma of the ureter in a 64-year-old man. (biomedcentral.com)
  • Multitarget fluorescence in situ hybridization (FISH) suggested that the development of the urothelial carcinoma in the ureter may be triggered or induced by the chondrosarcoma component. (biomedcentral.com)
  • This is the first reported case of a primary mesenchymal chondrosarcoma of the kidney with coexisting infiltrating urothelial carcinoma of the ureter. (biomedcentral.com)
  • Mesenchymal chondrosarcoma is a rare entity originally described in the literature as a biphasic tumour consisting of spindle cell mesenchyme mixed with areas of chondroid differentiation. (scielo.org.za)
  • Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. (semanticscholar.org)
  • Histologically, the tumour showed a biphasic pattern made up of solid areas of round and spindle-shaped mesenchymal cells interspersed with islands of well-differentiated cartilage. (scielo.org.za)
  • A small minority of secondary chondrosarcomas occur in patients with Maffucci syndrome and Ollier disease. (wikipedia.org)
  • Although there are exceptions, chondrosarcomas occur mainly in older adults forty to sixty years old and typically occur more in men than in women. (encyclopedia.com)
  • Chondrosarcoma can occur in the arms, legs, or the trunk of the body. (pennmedicine.org)
  • Chondrosarcomas most often occur in males. (thefreedictionary.com)
  • One such tumour, the chondrosarcoma, the most malignant cartilage tumour, represents 0.15% of all cranial space occupying lesions and 6% of all skull base tumours. (bmj.com)
  • Patients with chondrosarcoma from the nasopharynx or the paranasal sinus and extending into the skull base and chondrosarcoma as part of the syndromal diseases Maffuci or Ollier were excluded. (bmj.com)