Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Chondrosarcoma, Mesenchymal
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
Chondroma
Chordoma
Myxosarcoma
Cartilage
Skull Base Neoplasms
Exostoses, Multiple Hereditary
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms, Connective and Soft Tissue
Osteosarcoma
Ribs
Pelvic Bones
Chondroitinases and Chondroitin Lyases
Chondromatosis, Synovial
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Osteochondroma
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Exophthalmos
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Fatal Outcome
Meningioma
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Meningeal Neoplasms
Privacy
Computer Security
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Informed Consent
Genetic Privacy
Internet
Health Insurance Portability and Accountability Act
Bone Plates
Encyclopedias as Topic
Dictionaries as Topic
Sarcoma
Bone and Bones
Sarcoma, Ewing
Lipomatosis
Hemangiopericytoma
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Hamartoma
Glomus Tumor
A blue-red, extremely painful vascular neoplasm involving a glomeriform arteriovenous anastomosis (glomus body), which may be found anywhere in the skin, most often in the distal portion of the fingers and toes, especially beneath the nail. It is composed of specialized pericytes (sometimes termed glomus cells), usually in single encapsulated nodular masses which may be several millimeters in diameter (From Stedman, 27th ed). CHEMODECTOMA, a tumor of NEURAL CREST origin, is also sometimes called a glomus tumor.
Lipoma
Hemangioendothelioma
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Lymphangioma
Neoadjuvant Therapy
Preoperative Care
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Combined Modality Therapy
Antineoplastic Combined Chemotherapy Protocols
Inhibitory effects of transforming growth factor-beta1 pretreatment on experimental pulmonary metastasis of MCS-1 Chinese hamster mesenchymal chondrosarcoma cells. (1/35)
Recent studies have suggested that transforming growth factor(TGF)-beta1 acts as a multifunctional regulator of cell growth, and also modifies tumor progression and metastasis. In the present study, we investigated the effects of TGF-beta1 on the proliferation and experimental pulmonary metastasis of MCS-1. MCS-1 are undifferentiated type cloned tumor cells established from a mesenchymal chondrosarcoma which spontaneously occurred in the soft tissue of a female Chinese hamster. MCS-1 cells were pretreated with TGF-beta1 (0, 0.05, 0.5, 2, 10 ng/ml) for 72 hours in a medium containing 1% fetal bovine serum, then tested for in vitro growth by the MTT method, in vivo growth by subcutaneous inoculation into athymic nude mice (1 x 10(6) cells/mouse) and experimental pulmonary metastasis by injection into the lateral tail vein of athymic nude mice (5 x 10(4) cells/mouse). TGF-beta1 significantly inhibited in vitro growth of MCS-1, depending on its concentrations, and also experimental metastasis with maximal inhibition at 0.5 or 2 ng/ml treatment compared to untreated controls. TGF-beta1, however, was ineffective for in vivo subcutaneous growth of MCS-1. These results indicated that TGF-beta1 might be an inhibitor of metastasis of mesenchymal chondrosarcomas including other types of non-epitherial cartilage or bone formation tumors. (+info)Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. (2/35)
Mesenchymal chondrosarcomas are small-cell malignancies named as chondrosarcomas due to the focal appearance of cartilage islands. In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms. We were able to trace all steps of chondrogenesis within mesenchymal chondrosarcoma by using characteristic marker genes of chondrocytic development. Starting from undifferentiated cells, which were negative for vimentin and any other mesenchymal marker, a substantial portion of the cellular (undifferentiated) tumor areas showed a chondroprogenitor phenotype with an onset of expression of vimentin and collagen type IIA. Cells in the chondroid areas showed the full expression panel of mature chondrocytes including type X collagen indicating focal hypertrophic differentiation of the neoplastic chondrocytes. Finally, evidence was found for transdifferentiation of the neoplastic chondrocytes to osteoblast-like cells in areas of neoplastic bone formation. These results establish mesenchymal chondrosarcoma as the very neoplasm of differentiating premesenchymal chondroprogenitor cells. The potential of neoplastic bone formation in mesenchymal chondrosarcoma introduces a new concept of neoplastic (chondrocytic) osteogenesis in musculoskeletal malignant neoplasms, which qualifies the old dogma that neoplastic bone/osteoid formation automatically implies the diagnosis of osteosarcoma. (+info)Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (3/35)
The level of prostaglandin D synthase (PGDS), a major protein constituent of cerebrospinal fluid (CSF), is altered in various brain diseases, including meningitis. However, its role in the brain remains unclear. PGDS is mainly synthesized in the arachnoid cells, the choroid plexus and oligodendrocytes in the central nervous system. Among brain tumors, meningiomas showed intense immunoreactivity to PGDS in the perinuclear region. Thus, PGDS has been considered a specific cell marker of meningioma. In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%). Except for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PGDS. Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. These findings suggest that meningeal HPCs may have a unique molecular phenotype that is distinct from that of the soft-tissue HPCs. The origin of meningeal HPCs may be more closely related to the arachnoid cells. (+info)Chondrosarcoma of bone: an oncological and functional follow-up study. (4/35)
We retrospectively analysed the course of 42 out of 45 patients suffering from different chondrosarcomas which were treated surgically. We found a prospective 5- and 10-year survival of 64% for both time intervals. Follow-up examination was possible in 21 of 45 patients. Most of them were staged as NED, one as AWD, and 8 of 45 were lost to follow-up. From 16 dead patients 12 died of the disease and 4 of unknown but not to tumor related reasons. Survival was depending significantly on the histopathological grade, and the stage according to Enneking's surgical staging system. Eleven out of forty-five patients developed metastases within a mean period of twelve months after surgery. The survival of these patients was significantly reduced. Patients with centrally located tumors exhibited a distinct but non-significant worse survival than those suffering from peripheral tumors. In 18% (8 of 45) recurrence of the tumor was evident within a mean period of 24 months (5-85). Functional evaluation was performed in 21 out of 28 alive patients. After a mean follow-up time of 72 months the mean score was 64% (23-100). Females exhibited a distinct but non-significant better result, the same was observed for peripheral locations compared to centrally located tumors. Regarding age, grade, and line of resection no tendency of any dependence was detected, but worst results were seen in those with a stage III tumor and dedifferentiated CS. (+info)Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. (5/35)
Cytogenetic studies of mesenchymal chondrosarcoma are few and to date, no specific or recurrent aberrations have been found. In this investigation, the cytogenetic and molecular cytogenetic (spectral karyotypic and fluorescence in situ hybridization) findings for two mesenchymal chondrosarcomas, one arising skeletally and the other extraskeletally, are reported. An identical Robertsonian translocation involving chromosomes 13 and 21 [der(13;21)(q10;q10)] was detected in both cases, possibly representing a characteristic rearrangement for this histopathologic entity. Both cases also exhibited loss of all or a portion of chromosomes 8 and 20 and gain of all or a portion of chromosome 12. The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms. (+info)Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. (6/35)
A young adult female Mastiff dog developed a large retroperitoneal mass, pleural effusion, and multiple pulmonary and pleural nodules. All masses were diagnosed as mesenchymal subtype chondrosarcomas, using histological and immunohistochemical criteria. Reports of canine extraskeletal mesenchymal chondrosarcomas (EMCs) are rare but involved animals less than 3 years of age in 60% of the cases. This is the first description of this type of tumor developing distant metastases. Evidence from this case and previous reports suggests that EMCs are associated with a poor prognosis. (+info)Mesenchymal chondrosarcoma originating from the femoral vein. (7/35)
Mesenchymal chondrosarcoma is a rare variant of chondrosarcomas characterized by a bimorphic pattern with areas of the undifferentiated malignant small cells and well differentiated cartilaginous islands.(1) It occurs most commonly in the bone but can also occur in the extraskeletal soft tissues, the brain, and the meninges. This type of tumor has also been described in the eyelids, parapharyngeal space, mediastinum, and the kidney.(1-5) An origin from the large vessels has not been reported in the medical literature. The authors report a case of mesenchymal chondrosarcoma originating from the femoral vein in a 28-year-old female patient, treated by the wide-margin resection. (+info)Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. (8/35)
BACKGROUND: Mesenchymal chondrosarcoma (MC) is an infrequent neoplasm, representing approximately 1% of all chondrosarcomas. Cytologic descriptions of MCs have been confined to rare case reports. In the current report, the authors describe their experience with the cytologic features of four MCs: two primary tumors and two metastatic lesions. METHODS: Four patients were diagnosed with MC at the authors' institution from 1994 to 2002. Three of four patients underwent fine-needle aspiration (FNA) biopsy as part of their diagnosis; in the fourth patient, imprint cytology was performed. Each tumor also received histologic confirmation. RESULTS: The patients studied included three females and one male. In three patients, the tumor presented initially as a soft tissue mass; whereas, in the remaining patient, the MC presented in the tibia. FNA results demonstrated small, oval-to-spindled cells with high nuclear-to-cytoplasmic ratios. Cells occurred singly and in clumps in a background of basophilic extracellular matrix. Histologic examination of each lesion demonstrated biphasic tumors, including focal areas of relatively mature cartilage formation as well as a small cell population. CONCLUSIONS: MC is a rare soft tissue tumor that occurs frequently in extraskeletal locations. FNA of these tumors can be diagnostic if the tumor is sampled appropriately and of critical features, such as the background extracellular matrix, are recognized. Given the propensity of these tumors to metastasize and the poor prognosis of patients with MC, early identification by FNA biopsy may allow earlier, more aggressive interventions. (+info)
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report<...
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case | Journal of Orthopaedic Case Reports
Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis | springermedizin.at
Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature | BMC Cancer | Full Text
Alvin Deguzman
Papers with the keyword Gastrointestinal clear cell sarcoma-like tumor | Read by QxMD
Dedifferentiated chondrosarcoma with pathological fracture - femur | Radiology Case | Radiopaedia.org
Bone: Dedifferentiated chondrosarcoma
A Study Of Chondrosarcoma, Bone And Cartilage Derived Cancer - Natural Height Growth
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Low-grade chondrosarcoma: sternum | Radiology Case | Radiopaedia.org
Plus it
chondrosarcoma in dogs skull
NewYork-Presbyterian Queens - Chondrosarcoma
NewYork-Presbyterian Queens - Chondrosarcoma
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma...
Mouth Cancer (Chondrosarcoma) in Dogs | petMD
Clear-cell chondrosarcoma of the maxilla Report of a case
Chondrosarcoma: Causes, Symptoms, Diagnosis and Treatment
Chondrosarcoma | Johns Hopkins Medicine
Chondrosarcoma
Treatment Options for Chondrosarcoma | Stanford Health Care
Polarity and Ploidy in Peripheral Chondrosarcoma Research Grant
Chondrosarcoma | Coliseum Health System
Supplementary Material for: MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β...
GLC cancer
Mca June 2011 Exam Paper - 442 Words
Most recent papers with the keyword ewing sarcoma neuroblastoma | Read by QxMD
IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...
Functional genomic analyses of the impact of global hypomethylation an by Christopher Allan Hamm
Chondrosarcoma: Its treatment by radiation, hyperthermia and bleomycin<...
Chondrosarcoma
Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma
Chondrosarcoma of the greater cornu of the hyoid: a case report and literature review.
An extraskeletal chondrosarcoma of the maxilla. A case report<...
Chondrosarcoma of the Thorax - Semantic Scholar
A chondrosarcoma in the anterior mediastinum mimicking a thymoma - Forskning - Region Hovedstaden
Old Maid Cat Lady: Cancer in Cats: Chondrosarcoma
Throat Cancer (Chondrosarcoma) in Dogs | PetMD
Treatments for chondrosarcoma - Canadian Cancer Society
Gentaur Molecular :US Biomax \ Osteosarcoma and chondrosarcoma tissue array, with stage, grade and TNM data, 80 cases 80 cores,...
Chondrosarcoma - OzRadOnc
Other shared propranolol examen oral
Dedifferentiated chondrosarcomas of the larynx: a report of two cases and review of the literature
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
MedPix Case - chondrosarcoma, low grade
Chondrosarcoma treatment in clinics of Kleinbartloff, prices, patient reviews - DocLandmed
Leksell Top 25 - Since 2005
Search Results | jns
My Results are in ~ Its Cancer - Shizzle Design
Bone sarcoma
Clear cell Clear cell chondrosarcomas are rare, slow-growing, and seldom spread. Mesenchymal Mesenchymal chondrosarcomas can ... "Mesenchymal chondrosarcoma , Radiology Reference Article , Radiopaedia.org". Radiopaedia. Müller S, Söder S, Oliveira AM, ... Most chondrosarcomas develop in the pelvis, legs or arms. Benign counterparts are known as enchondromas. Chondrosarcomas are ... "Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton". Mod ...
IRF2BP2 (gene)
... in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC ...
Randy Miller (musician)
Miller was diagnosed with mesenchymal chondrosarcoma, a form of bone cancer, in 2008, the same year that With Arrows, With ...
Cancer epigenetics
Expression of epigenetic modifiers such as that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcoma, ... Sarcomas comprise a large number of rare, histogenetically heterogeneous mesenchymal tumors that, for example, include ... Similarly, expression of another epigenetic modifier, the LSD1 histone demethylase, is increased in chondrosarcoma, Ewing's ... Bennani-Baiti IM (December 2011). "Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis ...
List of MeSH codes (C04)
... chondrosarcoma MeSH C04.557.450.565.280.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.565.380 - giant cell tumors MeSH ... chondrosarcoma MeSH C04.557.450.795.300.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.795.350 - fibrosarcoma MeSH C04.557. ...
Small-blue-round-cell tumor
... the more common fetal and embryonal types do not Merkel cell carcinoma Mesenchymal chondrosarcoma Endometrial stromal ...
International Classification of Diseases for Oncology
Myxoid chondrosarcoma M9240/3 Mesenchymal chondrosarcoma M9241/0 Chondromyxoid fibroma M9242/3 Clear cell chondrosarcoma M9243/ ... NOS Mixed mesenchymal tumor M8990/3 Mesenchymoma, malignant Mixed mesenchymal sarcoma M8991/3 Embryonal sarcoma M9000/0 Brenner ... M9221/0 Juxtacortical chondroma Periosteal chondroma M9221/3 Juxtacortical chondrosarcoma Periosteal chondrosarcoma M9230/0 ... 3 Dedifferentiated chondrosarcoma M9250/1 giant cell tumor of bone, NOS Osteoclastoma, NOS M9250/3 Giant cell tumor of bone, ...
Sarcoma
Yang J, Ren Z, Du X, Hao M, Zhou W (27 October 2014). "The role of mesenchymal stem/progenitor cells in sarcoma: update and ... Some sarcomas, such as leiomyosarcoma, chondrosarcoma, and gastrointestinal stromal tumor (GIST), are more common in adults ... A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. ... These subtypes are as follows: Osteosarcoma Chondrosarcoma Poorly differentiated round/spindle cell tumors (includes Ewing ...
Index of trauma and orthopaedics articles
Mesenchymal chondrosarcoma - Metaphysis - Metatarsophalangeal joint sprain - Microfracture surgery - Milch classification - ... Myxoid chondrosarcoma National hip fracture database - Neer classification - Neer impingement sign - Neer's prosthesis - ... Chondrosarcoma - Chopart's fracture-dislocation - Clarke's test - Clavicle fracture - Clay-shoveler fracture - Cleidocranial ...
Chondrosarcoma
IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal ... CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma : Cancerbackup". Archived from the original on 2008- ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Media related to Chondrosarcoma at ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ...
Extraskeletal myxoid chondrosarcoma
... (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ... "Myxoid Chondrosarcoma - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-02-04. Rubin, Brian P.; ... Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. OCLC ... when they discussed the different species of extraskeletal chondrosarcoma, but EMC concept was firstly proposed in 1972 by ...
Chondroblast
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... As suggested in the name, mesenchymal progenitors originate from the mesoderm. These cells, when forming from the mesoderm, ... Day, Timothy F.; Guo, Xizhi; Garrett-Beal, Lisa; Yang, Yingzi (2005). "Wnt/β-Catenin Signaling in Mesenchymal Progenitors ... Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ...
Osteoid osteoma
Chondrosarcoma *Mesenchymal chondrosarcoma. *Myxoid chondrosarcoma. *Osteochondroma *Osteochondromatosis. *Chondromyxoid ...
WHO classification of tumours of the central nervous system
3.2 Mesenchymal tumours 3.2.1 Lipoma (ICD-O 8850/0) 3.2.2 Angiolipoma (ICD-O 8861/0) 3.2.3 Hibernoma (ICD-O 8880/0) 3.2.4 ... 3.2.13 Chondrosarcoma (ICD-O 9220/3) 3.2.14 Osteoma (ICD-O 9180/0) 3.2.15 Osteosarcoma (ICD-O 9180/3) 3.2.16 Osteochondroma ( ...
IFFO1
However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... especially mesenchymal cells. The vimentin protein is also responsible for maintaining cell shape, integrity of the cytoplasm, ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...
Metaphysis
The metaphysis contains a diverse population of cells including mesenchymal stem cells, which give rise to bone and fat cells, ... Metaphyseal tumors or lesions include osteosarcoma, chondrosarcoma, fibrosarcoma, osteoblastoma, enchondroma, fibrous dysplasia ...
Ectomesenchymal chondromyxoid tumor
... mesenchymal cells. There are some who think it is a myoepithelial tumor type. Derived from ectomesenchymal cells migrating from ... extraskeletal myxoid chondrosarcoma, focal oral mucinosis, and an ossifying fibromyxoid tumor of soft parts. Exceedingly rare, ...
List of cancer types
... each of which develop from cells originating in mesenchymal cells outside of the bone marrow. Lymphoma and leukemia: These two ... Chondrosarcoma Ewing's sarcoma Malignant fibrous histiocytoma of bone/osteosarcoma Osteosarcoma Rhabdomyosarcoma Leiomyosarcoma ...
Chondroblastoma
Romeo et al have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal ... clear cell chondrosarcomas, and enchondromas (this list is not exhaustive). Chondroblastoma has not been known to spontaneously ... These findings suggest that chondroblastoma is derived from a mesenchymal cell undergoing chondrogenesis via active growth- ... any definitive determinations regarding the origin of this neoplasm are not possible because of the plasticity of mesenchymal ...
Kostniakomięsak, wolna encyklopedia
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. „J Pathol". ... Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. „Clin Orthop Relat Res". 459, s. 40-7, Jun ... Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.. „Med Sci Monit". 17 (8), s. RA177-190 ...
List of OMIM disorder codes
GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... RSPO4 Anterior segment mesenchymal dysgenesis; 107250; FOXE3 Anterior segment mesenchymal dysgenesis; 107250; PITX3 ... 612237; TFG Chondrosarcoma, extraskeletal myxoid; 612237; CSMF Chorea, hereditary benign; 118700; NKX2-1 Choreoacanthocytosis; ...
Osteosarcoma
Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and ... Differential diagnosis of the osteosarcoma of the skull in particular includes, among others, chondrosarcoma and the ...
Index of oncology articles
... chondrosarcoma - chordoma - chorioallantoic membrane - choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic ... mesenchymal - mesenteric membrane - mesna - mesonephroma - mesothelioma - metaplasia - metaplastic carcinoma - metastasectomy ...
TBX3
Volckaert T, De Langhe SP (March 2015). "Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development". ... chondrosarcoma, fibrosarcoma, liposarcoma, rhabdomyosarcoma and synovial sarcoma) and there is compelling evidence that it ...
Rhabdomyosarcoma
... (RMS), is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully ... chondrosarcoma, or angiosarcoma". The American Journal of Surgical Pathology. 26 (9): 1175-1183. doi:10.1097/00000478-200209000 ...
Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review
... Michael W. Bishop,1,2 ... Mesenchymal chondrosarcoma is an aggressive, uncommon histologic entity arising in bone and soft tissues. We reviewed our ... We conducted a retrospective chart review on patients with mesenchymal chondrosarcoma over a 24-year period. Clinicopathologic ... Aggressive surgical resection of mesenchymal chondrosarcoma with chemoradiotherapy yields excellent local control and may ...
Metastatic mesenchymal chondrosarcoma
Extraskeletal mesenchymal chondrosarcoma. Radiology 1993;186:819-26. [ Links ]. 13. Aryoshi Y, Shimahara M. Mesenchymal ... It has also been established that mesenchymal chondrosarcoma expresses Sox-9 gene, a regulator in mesenchymal cell ... Mesenchymal chondrosarcoma of the jaws. Oral Surg Oral Md Oral Pathol 1982;54:197-206. [ Links ]. ... Mesenchymal chondrosarcoma of bone and soft tissue. A review of 111 cases. Cancer 1986;57:2444-453. [ Links ]. ...
Extraskeletal mesenchymal chondrosarcoma of the thigh
Pathologically, the main difference between extraskeletal myxoid chondrosarcoma and extraskeletal mesenchymal chondrosarcoma is ... and Dowling reported the first case of an extraskeletal mesenchymal chondrosarcoma in 1964.8,9 Extraskeletal mesenchymal ... Mesenchymal chondrosarcoma. J Bone Joint Surg Am. 1964;46:. 747. -754.. * Lightenstein L, Bernstein D. Unusual benign and ... Extraskeletal mesenchymal chondrosarcoma is a rare form of sarcoma that is not connected to bone, but typically involves the ...
Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon...
Identification of the novel HEY1-NCOA2 fusion in the mesenchymal chondrosarcoma case UF5. A, Upper: partial schema of HEY1 and ... RT-PCR detection of the HEY1-NCOA2 fusion in additional mesenchymal chondrosarcoma cases. Upper panel: RT-PCR performed using ... Exon expression plot of NCOA2 in the mesenchymal chondrosarcoma sample UF5, showing the intragenic change in NCOA2 expression. ... Interphase FISH detection of HEY1-NCOA2 fusion in mesenchymal chondrosarcomas. A, the schema of FISH-probe design. B, ...
Response to: Periosteal mesenchymal chondrosarcoma of the tibia | Springer for Research & Development
Khalil and colleagues for their comments [1]. We agree that the discovery of the fusion testing in mesenchymal chondrosarcoma ... Periosteal mesenchymal chondrosarcoma of the tibia. Skeletal Radiol. https://doi.org/10.1007/s00256-018-2885-9. ... It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal ... chondrosarcomas, particularly those with less than optimal pathologic features or sampling. We intend to make use of testing ...
Mesenchymal chondrosarcoma of maxilla in paediatric patient | BMJ Case Reports
Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis | springermedizin.at
Mesenchymal chondrosarcoma of the orbit: CT and MRI Findings. Clin Radiol. 2012;67:346-51. CrossRefPubMed ... Mesenchymal chondrosarcoma of the orbit: CT and MRI Findings. Clin Radiol. 2012;67:346-51. CrossRefPubMed Yang BT, Wang YZ, ... Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. Clin Imaging. 2012;36:365-70. CrossRefPubMed ... Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis. Case report and review of the ...
Molecular Testing for Mesenchymal Chondrosarcoma
Learn in-depth information on Molecular Testing for Mesenchymal Chondrosarcoma, on why the laboratory test is performed, ... Test for Molecular Diagnosis of Mesenchymal Chondrosarcoma. What is Molecular Testing for Mesenchymal Chondrosarcoma? ( ... Molecular Testing for Mesenchymal Chondrosarcoma is a genetic test that is helpful in aiding a diagnosis of mesenchymal ... Molecular Testing for Mesenchymal Chondrosarcoma is a genetic test that is helpful in aiding a diagnosis of mesenchymal ...
Chondrosarcoma, Mesenchymal - Semantic Scholar
Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in ... A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed ... Chondrosarcoma, Mesenchymal. Known as: Chondrosarcomas, Mesenchymal, chondrosarcoma mesenchymal, Mesenchymal Chondrosarcoma ( ... Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 ...
Chondrosarcoma: Practice Essentials, Background, Pathophysiology
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... Mesenchymal chondrosarcoma. The 5-year survival rate for mesenchymal chondrosarcoma is less than 50%, with an overall 10-year ... Fewer than 2% of all chondrosarcomas are mesenchymal chondrosarcomas. The maxilla and the mandible are the most common sites of ... encoded search term (Chondrosarcoma) and Chondrosarcoma What to Read Next on Medscape. Related Conditions and Diseases. * Fast ...
Mesenchymal chondrosarcoma - Libre Pathology
Chondrosarcoma.. References. *↑ Dowling EA (June 1964). "Mesenchymal chondrosarcoma". J Bone Joint Surg Am 46: 747-54. PMID ... Mesenchymal chondrosarcoma is a rare type of chondrosarcoma that is found in the soft tissue. ... Jun 2011). "[Clinicopathologic and immunohistochemical study of 23 cases of mesenchymal chondrosarcoma].". Zhonghua Bing Li Xue ... May 2010). "Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ...
Mesenchymal Chondrosarcoma : Tumors of the bone
Radiation is used in selected cases, particularly extraskeletal mesenchymal chondrosarcomas. *Wide/Radical limb sparing surgery ... Thank-you so very much for being my surgeon for that chondrosarcoma, for saving my life! And I have learned over the months ( ... Undifferentiated mesenchymal cells similar to Ewing sarcoma. *Low grade islands of cartilage scattered throughout the ...
Mesenchymal chondrosarcoma of maxilla : a rare case report
Mesenchymal chondrosarcoma (MC) is a rare variant of chondrosarcoma (CS) that accounts for upto 3-9% of all CS and has high ... Mesenchymal chondrosarcoma of maxilla : a rare case report. DSpace Repository. Valencià Castellano ... Mesenchymal chondrosarcoma of maxilla : a rare case report. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 ... Mesenchymal chondrosarcoma of maxilla : a rare case report. Show simple item record ...
Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma<...
Some mesenchymal chondrosarcomas have a t(11;22) translocation suggesting a relationship with the PNET/Ewing tumor family. We ... Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. / Gatter, Ken M.; Olson, ... Some mesenchymal chondrosarcomas have a t(11;22) translocation suggesting a relationship with the PNET/Ewing tumor family. We ... N2 - Mesenchymal chondrosarcoma is a rare malignant tumor that comprises about 3-10% of all sarcomas. Reports of cytogenetic ...
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report<...
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report. Together they form a unique fingerprint. * Mesenchymal ... Intracranial extraskeletal mesenchymal chondrosarcoma: Case report. Kimberly D. Bingaman, Cargill H. Alleyne, Jeffrey J. Olson ... CONCLUSION: Intracranial mesenchymal chondrosarcoma is a rare neoplasm that can mimic a meningioma radiographically. We present ... CONCLUSION: Intracranial mesenchymal chondrosarcoma is a rare neoplasm that can mimic a meningioma radiographically. We present ...
Soft Tissue Sarcoma | Vanderbilt-Ingram Cancer Center
Extraskeletal mesenchymal chondrosarcoma. Treatment of extraskeletal mesenchymal chondrosarcoma may include the following: * ... Extraskeletal mesenchymal chondrosarcoma . This type of bone and cartilage tumor often affects young adults and occurs in the ... Extraskeletal myxoid chondrosarcoma. Treatment of extraskeletal myxoid chondrosarcoma may include the following:. * Surgery to ... Extraskeletal myxoid chondrosarcoma . This type of soft tissue sarcoma may occur in children and adolescents. Over time, it ...
January/February 2012 - Volume 17 - Issue 1 : AJSP: Reviews & Reports
Primary extraskeletal mesenchymal chondrosarcoma of the vulva | Obstetrics & Gynecology Science;: 345-348, 2013. | WPRIM
Full text: Available Index: WPRIM (Western Pacific) Main subject: Vulva / Humans / Chondrosarcoma / Chondrosarcoma, Mesenchymal ... Full text: Available Index: WPRIM (Western Pacific) Main subject: Vulva / Humans / Chondrosarcoma / Chondrosarcoma, Mesenchymal ... The final pathological reports confirmed extraskeletal mesenchymal chondrosarcoma (EMC) of the vulva revealing no microscopic ... Extraskeletal chondrosarcoma is rare, making up only 1% of reported chondrosarcoma. We experienced 3 cases of extraskeletal ...
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case | Journal of Orthopaedic Case Reports
Overall, mesenchymal chondrosarcomas included less than 10% of all type of chondrosarcomas and often originates from the ... You are at:Home » Sep - Oct 2016 , Volume 6 , Issue 4 » Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare ... Mesenchymal chondrosarcoma of bone and soft tissues. Cancer. 1983;52:533-541.. 4. Seo C, Jung S T, Byun J W. Extraskeletal ... Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. J Hand Surg Am. 2007;32:389-392.. 3. Bertoni F, Picci P ...
Radiological features of extraskeletai mesenchymal chondrosarcoma | Chinese Journal of Radiology;(12): 248-251, 2012. | WPRIM
Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma | SpringerLink
Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to ... Metastatic chondrosarcoma of mesenchymal origin is the second most common bone malignancy and does not respond either to ... PRP-1 inhibits mesenchymal tumors. Tumour Biol. 2011;32(4):745-51.PubMedCrossRefGoogle Scholar ... Kinome profiling of chondrosarcoma reveals Src-pathway activity and dasatinib as option for treatment. Cancer Res. 2009;69:6216 ...
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report | Journal of Orthopaedic...
However no such concomitance has been reported with chondrosarcoma. We report the first case of mesenchymal chondrosarcoma ... Immunohistochemical and morphological findings revealed malignant mesenchymal chondrosarcoma. Conclusion: IH is well known to ... results of surgery depending on location or extension to unresectable sites of majority of mesenchymal chondrosarcomas. ... But no such association has been reported with chondrosarcoma. In musculoskeletal masses of patients with hemihyperplasia, the ...
Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma
Make research projects and school reports about Chondrosarcoma easy with credible articles from our FREE, online encyclopedia ... clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the ... Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. Central chondrosarcoma occurs within a ... Mesenchymal chondrosarcoma is another rare variant. However, as opposed to clear cell chondrosarcoma, it is highly malignant ...
Global Chondrosarcoma Market Report 2017 Estimated To Grow Worldwide By 2022: Global QYResearch | Medgadget
This report studies Global Chondrosarcoma Market, especially in North America, China, Europe, Southeast Asia, Japan and India, ... Conventional Chondrosarcoma. Clear Cell Chondrosarcoma. Myxoid Chondrosarcoma. Mesenchymal Chondrosarcoma. Dedifferentiated ... 1.2.4 Mesenchymal Chondrosarcoma. 1.2.5 Dedifferentiated Chondrosarcoma. 1.2.6 Others. 1.3 Applications of Chondrosarcoma. 1.3. ... 6.3.3 Myxoid Chondrosarcoma of Chondrosarcoma Growth Driving Factor Analysis. 6.3.4 Mesenchymal Chondrosarcoma of ...
Images & Histologies of Extraskeletal Mesenchymal Chondrosarcoma | Sarcoma Images | A Descriptive Image Database of Bone & Soft...
Bone Sarcomas | Johns Hopkins Medicine
Diagnostic Radiology/Musculoskeletal Imaging/Tumors Advanced - Wikibooks, open books for an open world
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With...
Mesenchymal (extraskeletal) chondrosarcoma. *Leiomyosarcoma. *Liposarcoma (excluding myxoid liposarcoma). *Undifferentiated ... extraskeletal myxoid chondrosarcoma, neoplasms with perivascular epithelioid cell differentiation (PEComa), intimal sarcoma, ... atypical fibroxanthoma, mixed tumor NOS, phosphaturic mesenchymal tumor, malignant ossifying fibromyxoid tumor, malignant mixed ...
"Mesenchymal Chondrosarcoma of the Sinonasal Cavity: A Case Report and " by Kevin P. Banks, Justin Q. Ly et al.
Histologically, mesenchymal chondrosarcomas are characterized by a mix of cartilage and undifferentiated stromal tissue. ... We present a case of mesenchymal chondrosarcoma presenting as chronic sinusitis, arising in the sinonasal cavity. Additionally ... Radiographically, they demonstrate features similar to the more commonly encountered conventional chondrosarcoma, with the ... Mesenchymal chondrosarcoma is a rare, highly malignant cartilaginous forming tumor that is rarely encountered in clinical ...
TumorsTumorExtraskeletal mesenchymalOsteosarcomaClear cell chondrosarcomaCase of mesenchymal chondrosarcomaMetastaticClassic features of mesenchymal chondrosarcomaType of chondrosarcomaHigh grade chondrosarcomaAggressivePatients with mesenchymal chondrosarcomaIntracranialFusion in mesenchymal chondrosarcomaHistologicBenignAdditional mesenchymal componentNeoplasmCentral chondrosarcomaDiagnosis of mesenchymalSubtypesChemotherapyApoptosis in human chondrosarcomaFibrosarcomaHuman chondrosarcoma cellsSoft tissuePrognosisConclusionSubtypePeriostealMaxillaDifferentiationHighly malignant variantMyxoid ChondrosarcomaPrimary chondrosarcomasLesionsHistologicalTypes of chondrosarcomaAtypicalSecondarySpindleYoung AdultsFibrousTreat chondrosarcomaCD99VariantOccurPelvisCarcinoma
Tumors21
- 1 Malignant cartilaginous tumors that are not connected to bone are called extraskeletal chondrosarcomas. (hcplive.com)
- 8,9 Extraskeletal mesenchymal chondrosarcomas are extremely rare, fully malignant tumors with an obscure etiology. (hcplive.com)
- In general, chondrosarcomas are malignant tumors that mostly arise in the bone. (dovemed.com)
- Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. (semanticscholar.org)
- Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
- PRP-1 inhibits mesenchymal tumors. (springer.com)
- Due to the location of chondrosarcoma tumors, the result is often a decrease in the range of motion of limbs, especially tumors occurring on the epiphysis of bones such as those seen in clear cell chondrosarcoma. (encyclopedia.com)
- However, researchers have discovered that chondrosarcomas are sometimes associated with underlying benign bone tumors. (encyclopedia.com)
- Moreover, in vivo chondrosarcoma xenograft study revealed a dramatic reduction in tumor volume and the increased SIRT1 and cleaved caspase-3 expressions in tumors by resveratrol treatment. (nature.com)
- Chondrosarcoma is one of the most common primary bone tumors ranking after myeloma and osteosarcoma, accounting for approximately 20% of bone sarcomas and may occur at any age between 10 and 80 years 1 . (nature.com)
- Peripheral de-differentiated chondrosarcomas are among the rarest malignant mesenchymal tumors. (hindawi.com)
- This investigation surveyed imaging of peripheral de-differentiated chondrosarcomas to facilitate better recognition of these uncommon tumors. (hindawi.com)
- Chondrosarcoma represents a heterogeneous group of cartilage-forming tumors. (aacrjournals.org)
- These tumors are treated by en bloc resection. (aacrjournals.org)
- Saglik, "Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients," Journal of Orthopaedic Science, vol. (thefreedictionary.com)
- Background: Sarcomas are rare tumors (1-2% of all cancers) of mesenchymal origin that may develop in soft tissues and viscera. (ebscohost.com)
- Analyzes the clinicoradiographic, microscopic and immunophenotypic features of 21 tumors from 13 patients with mesenchymal chondrosarcoma neoplasms. (ebscohost.com)
- FAS-positive sarcomas were found in 13 of 23 malignant fibrous histiocytomas, 3 of 17 liposarcomas, 3 of 7 malignant peripheral nerve sheath tumors, and 1 extraskeletal mesenchymal chondrosarcoma. (aacrjournals.org)
- The gene was originally identified because of its amplification in a human glioblastoma, and previous studies have shown it to be amplified in a significant proportion of mesenchymal tumors, such as childhood sarcomas. (aacrjournals.org)
- Samples from 40 patients (37 sarcomas and 3 benign mesen chymal tumors) and samples of 15 normal mesenchymal tissues were examined for GLI gene amplification and expression by Southern hybridization, reverse transcription-PCR of tissue RNA, and immunohisto- chemistry, using a new polyclonal GLI antibody developed against an epitope outside of the zinc finger region. (aacrjournals.org)
- A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. (wikipedia.org)
Tumor33
- The patient underwent tumor resection and a biopsy confirmed the presence of a mesenchymal chondrosarcoma. (springermedizin.at)
- Mesenchymal chondrosarcoma is a rare malignant tumor that comprises about 3-10% of all sarcomas. (elsevier.com)
- Some mesenchymal chondrosarcomas have a t(11;22) translocation suggesting a relationship with the PNET/Ewing tumor family. (elsevier.com)
- Extraskeletal chondrosarcoma is a rare tumor which originates in the soft tissue compartment and is classified as myxoid and mesenchymal based on histologic criteria. (jocr.co.in)
- Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue around joints. (encyclopedia.com)
- Depending on the type and location of the chondrosarcoma, the tumor can either be high grade and aggressive or low grade and not as invasive. (encyclopedia.com)
- Mesenchymal chondrosarcoma is a malignant tumor which originates from chondrogenic tissue. (jocr.co.in)
- chondrosarcoma, hemihyperplasia, mesenchymal tumor. (jocr.co.in)
- Mesenchymal chondrosarcoma is a rare, highly malignant cartilaginous forming tumor that is rarely encountered in clinical practice. (wright.edu)
- Radiographically, they demonstrate features similar to the more commonly encountered conventional chondrosarcoma, with the tumor location and patient age helping to suggest the correct diagnosis. (wright.edu)
- Chondrosarcoma is a malignant primary bone tumor. (nature.com)
- Here, we investigated the role of SIRT1 induction by resveratrol in human chondrosarcoma cell growth and tumor progression. (nature.com)
- Primary mesenchymal chondrosarcoma of the kidney is rare, and it shows distinct undifferentiated tumor cells and well differentiated cartilagenous components. (biomedcentral.com)
- The imaging characteristics described for central de-differentiated chondrosarcomas are similar to the peripheral form of this tumor. (hindawi.com)
- Dedifferentiation to leiomyosarcoma, giant cell tumor , and rarely, clear-cell chondrosarcoma or rhabdomyosarcoma has been reported. (atlasgeneticsoncology.org)
- Chondrosarcoma is a malignant cartilage forming bone tumor, in which mutations altering isocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) activity have been identified as potential driver mutations. (aacrjournals.org)
- The far most prevalent subtype (72% of the cases) is conventional central chondrosarcoma, in which the tumor arises centrally in the medulla of the bone. (aacrjournals.org)
- This subtype can be histologically subdivided into atypical cartilaginous tumor (ACT), grade II and grade III chondrosarcomas. (aacrjournals.org)
- Chondrosarcoma patients with unresectable disease, due to tumor location, tumor size, or extensive metastatic disease, have a 5-year survival of only 2% as the overall efficacy of chemotherapy is limited ( 8, 9 ). (aacrjournals.org)
- Mesenchymal chondrosarcoma (MCHS) is a highly aggressive, malignant, cartilaginous tumor that represents about 1% of all chondrosarcomas. (entjournal.com)
- Possible signs of chondrosarcoma include pain and swelling near the tumor. (pennmedicine.org)
- The malignant cartilage bone tumor is called chondrosarcoma. (lumc.nl)
- Insulin increases synthesis of mucopolysaccharides in the chondrocytes whereas it elevates synthesis of proteoglycans in the tumor cells obtained from the chondrosarcoma cells. (thefreedictionary.com)
- Chondrosarcoma is a malignant mesenchymal tumor that produces cartilaginous matrix. (thefreedictionary.com)
- Soft tissue sarcomas, such as leiomyosarcoma , chondrosarcoma , and gastrointestinal stromal tumor (GIST) , are more common in adults than in children. (wikidoc.org)
- Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes. (biomedsearch.com)
- Conventional chondrosarcoma can be a difficult tumor to treat. (sarctrials.org)
- Grade 1 chondrosarcomas almost never metastasize and are now called "atypical cartilaginous tumor", Grade 2 chondrosarcomas have only a 10-15% risk of metastasis, and grade 3 chondrosarcomas have a two-thirds or higher risk of metastasis. (sarctrials.org)
- It shows features of both chondrosarcoma and a less differentiated tumor, such as UPS (undifferentiated pleomorphic sarcoma), which does not show even a hint of relatedness to the chondrosarcoma. (sarctrials.org)
- This rare bone tumor shows a mixture of aggressive small round blue cells mixed with more typical lower-grade chondrosarcoma. (sarctrials.org)
- In addition to confirming the importance of GLI in mesenchymal differentiation, the data suggest a relationship between GLI gene expression and tumor grade. (aacrjournals.org)
- Specimens from 40 patients were used in this study [37 samples of bone and soft tissue sarcomas of various histological types (MPNST, leiomyosarcomas, liposarcomas, osteosarcomas, chondrosarcomas, MFH, and others) and 3 samples of mesenchymal benign neoplasias] as well as 15 samples of normal mesenchymal tissues originating from those tumor excisions. (aacrjournals.org)
- Musculoskeletal tumor specialists or orthopedic oncologists are usually chosen to treat chondrosarcoma, unless it is located in the skull, spine, or chest cavity, in which case, a neurosurgeon or thoracic surgeon experienced with sarcomas is chosen. (wikipedia.org)
Extraskeletal mesenchymal10
- Microscopic evaluation revealed a biomorphic pattern composed of undifferentiated round or oval cells resembling embryonal mesenchyme and well-differentiated cartilaginous tissue, which is a characteristic finding of extraskeletal mesenchymal chondrosarcoma (Figure 4). (hcplive.com)
- Lightenstein and Bernstein first described mesenchymal chondrosarcomas in 1959, and Dowling reported the first case of an extraskeletal mesenchymal chondrosarcoma in 1964. (hcplive.com)
- Extraskeletal mesenchymal chondrosarcomas involve muscles or the central nervous system. (hcplive.com)
- Extraskeletal mesenchymal chondrosarcoma. (semanticscholar.org)
- OBJECTIVE AND IMPORTANCE: We present a patient with a dural-based intracranial extraskeletal mesenchymal chondrosarcoma, which was initially thought to be an atypical meningioma. (elsevier.com)
- Pathological examination revealed an extraskeletal mesenchymal chondrosarcoma. (elsevier.com)
- The final pathological reports confirmed extraskeletal mesenchymal chondrosarcoma (EMC) of the vulva revealing no microscopic lesions on the resection margins . (bvsalud.org)
- Objective To explore CT,MRI findings of extraskeletal mesenchymal chondrosarcoma (EMC). (bvsalud.org)
- Management of renal extraskeletal mesenchymal chondrosarcoma. (springer.com)
- Extraskeletal mesenchymal chondrosarcoma is rare, and uaually arises in the head and neck region, followed by the lower extremity, the trunk and the retroperitoneum. (biomedcentral.com)
Osteosarcoma9
- There are three main types of bone sarcoma based on tissue type - an osteosarcoma, a Ewing's sarcoma, and a chondrosarcoma. (wikipedia.org)
- Subtypes of chondrosarcomas have different features and different outlooks, they include:[citation needed] Dedifferentiated Dedifferentiated chondrosarcomas can change in part to cells that are like those of an osteosarcoma for example which has a faster rate of growth. (wikipedia.org)
- A dedifferentiated chondrosarcoma tumour is treated like an osteosarcoma tumour because it is a more aggressive type of chondrosarcoma. (cancer.ca)
- Dedifferentiated chondrosarcoma may be treated with some of the same chemotherapy drugs that are used for osteosarcoma . (cancer.ca)
- The non-cartilaginous component of dedifferentiated chondrosarcoma is generally an osteosarcoma , a fibrosarcoma, or a malignant fibrous histiocytoma. (atlasgeneticsoncology.org)
- With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
- Rare primary bone malignancies such as clear cell chondrosarcoma and giant cell rich osteosarcoma can also mimic GCTB but often have more destructive features, adjacent bone marrow edema, and/or a soft tissue mass component. (thefreedictionary.com)
- For example, osteosarcoma arises from bone , chondrosarcoma arises from cartilage , and leiomyosarcoma arises from smooth muscle . (wikidoc.org)
- Patients with the following types of bone sarcoma: Ewing sarcoma, osteosarcoma, and chondrosarcoma [de-differentiated or mesenchymal]. (clinicaltrials.gov)
Clear cell chondrosarcoma6
- There are three variant chondrosarcomas: clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. (encyclopedia.com)
- Clear cell chondrosarcoma is the most rare form of chondrosarcoma. (encyclopedia.com)
- However, as opposed to clear cell chondrosarcoma, it is highly malignant and frequently metastasizes, commonly to the lungs, lymph nodes and other bones. (encyclopedia.com)
- Four histological subtypes of chondrosarcoma are described as peripheral-, dedifferentiated-, mesenchymal- and clear cell chondrosarcoma. (lumc.nl)
- Clear cell chondrosarcoma of bone: a report of 8 cases. (thefreedictionary.com)
- A version of chondrosarcoma called clear-cell chondrosarcoma has an intermediate risk of metastasis, but treatment is typically surgery alone. (sarctrials.org)
Case of mesenchymal chondrosarcoma5
- We report the first case of mesenchymal chondrosarcoma presenting with isolated hemihypertrophy. (jocr.co.in)
- We report a case of mesenchymal chondrosarcoma arising from the left ankle region of a patient with isolated hemihypertrophy of right side of her body. (jocr.co.in)
- We present a case of mesenchymal chondrosarcoma presenting as chronic sinusitis, arising in the sinonasal cavity. (wright.edu)
- We describe a rare case of mesenchymal chondrosarcoma of the thyroid gland with uncertain primary origin. (biomedcentral.com)
- We report another case of mesenchymal chondrosarcoma of the kidney with synchronous implant and a coexistent infiltrating urothelial carcinoma of the ureter firstly. (biomedcentral.com)
Metastatic2
- Both primary and metastatic mesenchymal chondrosarcoma found in the thyroid gland are extremely rare. (biomedcentral.com)
- Dedifferentiated chondrosarcoma accounts for approximately 10% of all chondrosarcomas and shows an increased growth rate and rapid metastatic spread in comparison with ordinary chondrosarcomas. (atlasgeneticsoncology.org)
Classic features of mesenchymal chondrosarcoma2
- Histopathological examination and immunohistochemical studuies showed the classic features of mesenchymal chondrosarcoma in kidney, as well as a few infiltrating urothelial in ureter. (biomedcentral.com)
- However, the amount of these spindled cells is small and not all the classic features of mesenchymal chondrosarcoma are seen on histology. (radiopaedia.org)
Type of chondrosarcoma4
- Mesenchymal chondrosarcoma is a rare type of chondrosarcoma that is found in the soft tissue . (librepathology.org)
- As the name implies, cells biopsied from this type of chondrosarcoma appear clear with many large vacuoles. (encyclopedia.com)
- Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. (cancer.ca)
- Mesenchymal Chondrosarcoma is a malignant type of chondrosarcoma, or cancer of cartilage. (cancerandcareers.org)
High grade chondrosarcoma4
- Galoian K, Temple TH, Galoyan A. Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma. (springer.com)
- however, the survival of high-grade chondrosarcoma patients is still poor after surgical therapy. (nature.com)
- Final diagnosis: high-grade chondrosarcoma . (radiopaedia.org)
- Recent studies have shown that induction of apoptosis in high-grade chondrosarcoma, both directly and by enhancement of response to chemotherapy and radiation, is a valid therapeutic strategy. (wikipedia.org)
Aggressive7
- Mesenchymal chondrosarcoma is an aggressive, uncommon histologic entity arising in bone and soft tissues. (hindawi.com)
- Aggressive surgical resection of mesenchymal chondrosarcoma with chemoradiotherapy yields excellent local control and may reduce likelihood of late recurrence. (hindawi.com)
- Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. (bmj.com)
- Extraskeletal chondrosarcomas (EMC) is a rare aggressive neoplasm which has been seen in the soft tissue area. (jocr.co.in)
- In type 1, the radiographic appearance is the same as for a central chondrosarcoma, with the addition of a region with very aggressive bone destruction. (atlasgeneticsoncology.org)
- Two other subtypes with a worse prognosis are dedifferentiated chondrosarcoma, a highly malignant variant ( 4 ), and mesenchymal chondrosarcoma, a rare aggressive subtype in which distant metastasis can be identified even after 20 years ( 5-7 ). (aacrjournals.org)
- This more aggressive version of chondrosarcoma typically occurs in adolescence and in people over age 60. (sarctrials.org)
Patients with mesenchymal chondrosarcoma1
- We conducted a retrospective chart review on patients with mesenchymal chondrosarcoma over a 24-year period. (hindawi.com)
Intracranial3
- Intracranial mesenchymal chondrosarcoma. (semanticscholar.org)
- CONCLUSION: Intracranial mesenchymal chondrosarcoma is a rare neoplasm that can mimic a meningioma radiographically. (elsevier.com)
- From these data we give an overview of the current diagnostic procedures and therapeutic options of intracranial chondrosarcoma. (bmj.com)
Fusion in mesenchymal chondrosarcoma1
- Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. (nih.gov)
Histologic4
- RT-PCR or FISH evidence of this HEY1-NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas. (nih.gov)
- Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
- This soft tissue sarcoma is classified to myxoid and mesenchymal based on histologic criteria. (jocr.co.in)
- Chondrosarcoma patients, especially those of high histologic grade with lower expression and hypermethylation of NAPRT, may benefit from inhibition of the NAD synthesis pathway. (aacrjournals.org)
Benign2
- Benign cartilage lesions can be difficult to differentiate from slow-growing, low-grade chondrosarcomas. (medscape.com)
- Secondary chondrosarcoma can occur in a previously benign cartilaginous lesion. (medscape.com)
Additional mesenchymal component1
- Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). (semanticscholar.org)
Neoplasm2
- 2 This neoplasm differs from other forms of chondrosarcoma in that the preponderance of occurrences are in young adults, generally those between the ages of 15 and 35 years, with a slightly higher incidence in women. (hcplive.com)
- Mesenchymal Chondrosarcoma: A Small Cell Neoplasm with Polyphenotypic Differentiation. (ebscohost.com)
Central chondrosarcoma2
- Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. (encyclopedia.com)
- Central chondrosarcoma occurs within a bone, and peripheral chondrosarcoma develops on the surface of a bone. (encyclopedia.com)
Diagnosis of mesenchymal2
- It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal chondrosarcomas, particularly those with less than optimal pathologic features or sampling. (springer.com)
- Molecular Testing for Mesenchymal Chondrosarcoma is a genetic test that is helpful in aiding a diagnosis of mesenchymal chondrosarcoma. (dovemed.com)
Subtypes1
- a cytogenetic and DNA flow cytometric analysis of chondrosarcoma subtypes. (thefreedictionary.com)
Chemotherapy6
- complete wide resection of mesenchymal chondrosarcoma could be enough as an initial treatment and chemotherapy reserved for patients that have unresectable masses. (jocr.co.in)
- Mesenchymal Mesenchymal chondrosarcomas can grow quickly but unlike other types may respond to radiotherapy, and chemotherapy. (wikipedia.org)
- Due to its poor response to both radiotherapy and chemotherapy, the management of chondrosarcoma faces a complicated challenge 2 . (nature.com)
- Chemotherapy is not used for low-grade chondrosarcoma because it has not been shown to help improve survival. (cancer.ca)
- What's the best chemotherapy protocol for mesenchymal chondrosarcoma stage 1b? (healthtap.com)
- As a result, some people with grade 3 chondrosarcomas are treated with adjuvant chemotherapy. (sarctrials.org)
Apoptosis in human chondrosarcoma2
- However, it is scarcely reported that SDF-1-Gab1 pathway mediates proliferation and apoptosis in human chondrosarcoma (CS). (springer.com)
- Resveratrol significantly decreased cell viability and induced cell apoptosis in human chondrosarcoma cells in a dose-dependent manner. (nature.com)
Fibrosarcoma1
- Among the less common are chondrosarcoma, fibrosarcoma , and malignant fibrous histiocytoma , all of which arise from spindle cell neoplasms. (encyclopedia.com)
Human chondrosarcoma cells2
- There is no report about the role of SIRT1 in the human chondrosarcoma cells. (nature.com)
- Both siRNA-SIRT1 transfection and MS-275 significantly inhibited the resveratrol-induced caspase-3 cleavage and activity in human chondrosarcoma cells. (nature.com)
Soft tissue2
- It is characterized by the presence of a mix of low-grade chondrosarcoma and has undergone malignant degeneration, producing a fully malignant soft tissue mass that is no longer identifiable as cartilage. (encyclopedia.com)
- Peripheral mineralization with a bimorphic pattern on CT scan and the presence of a soft-tissue mass should be considered worrisome for a peripheral de-differentiated chondrosarcoma, particularly in the setting of multiple hereditary exostoses. (hindawi.com)
Prognosis1
- The mesenchymal subtype has a poor prognosis. (jocr.co.in)
Conclusion1
- In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma. (aacrjournals.org)
Subtype2
- It is a subtype of chondrosarcoma, a term that includes a heterogeneous group of lesions with varied clinical behaviour and morphological features that share the common feature arising from ossified cartilage or cartilaginous rests. (scielo.org.za)
- Generally, mesenchymal subtype included less than 10% of all types of chondrosarcomas and is more common in the bone [1-3]. (jocr.co.in)
Periosteal2
- Khalil S, Al-Rahawan MG, Al-Rahawan MM. Periosteal mesenchymal chondrosarcoma of the tibia. (springer.com)
- 2. Juxtacortical (Periosteal) Chondrosarcoma. (bokus.com)
Maxilla3
- Chondrosarcoma of the maxilla: a case report and review of literature. (springermedizin.at)
- Chondrosarcoma of the maxilla: report of two cases with different behaviours. (springermedizin.at)
- Zurück zum Zitat Gawande M, Swastika N, Chaudhary M, Patil S. Chondrosarcoma of maxilla. (springermedizin.at)
Differentiation2
- Mesenchymal chondrosarcoma is a rare entity originally described in the literature as a biphasic tumour consisting of spindle cell mesenchyme mixed with areas of chondroid differentiation. (scielo.org.za)
- Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. (semanticscholar.org)
Highly malignant variant1
- Dedifferentiated chondrosarcoma is a highly malignant variant of chondrosarcoma. (semanticscholar.org)
Myxoid Chondrosarcoma3
- Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene ma. (genecards.org)
- Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. (genecards.org)
- Diseases associated with TAF15 include Chondrosarcoma, Extraskeletal Myxoid and Myxoid Chondrosarcoma . (genecards.org)
Primary chondrosarcomas2
- 2-10% of primary chondrosarcomas. (librepathology.org)
- Seventy-six percent of primary chondrosarcomas occur centrally within a bone. (encyclopedia.com)
Lesions1
- One such tumour, the chondrosarcoma, the most malignant cartilage tumour, represents 0.15% of all cranial space occupying lesions and 6% of all skull base tumours. (bmj.com)
Histological2
- A left thyroid lobectomy was done and the histological features suggestive of mesenchymal chondrosarcoma (MC) were established. (scielo.org.za)
- On histological examination 51% of tumours were classified as grade I, 11% grade II, 30% mesenchymal, and 8% myxoïd. (bmj.com)
Types of chondrosarcoma1
- Surgery is the main treatment for most types of chondrosarcoma. (cancer.ca)
Atypical1
- There is chondroid matrix, containing atypical chondrocytes, in keeping with a chondrosarcoma. (radiopaedia.org)
Secondary1
- A small minority of secondary chondrosarcomas occur in patients with Maffucci syndrome and Ollier disease. (wikipedia.org)
Spindle3
- Histologically, the tumour showed a biphasic pattern made up of solid areas of round and spindle-shaped mesenchymal cells interspersed with islands of well-differentiated cartilage. (scielo.org.za)
- original magnification, 10x) shows abrupt transition between a low grade chondrosarcoma (left) and a high grade spindle cell sarcoma (right). (atlasgeneticsoncology.org)
- The presence of CD99 positive spindle cells suggests mesenchymal chondrosarcoma . (radiopaedia.org)
Young Adults1
- Teens and young adults are most prone to mesenchymal chondrosarcoma. (dovemed.com)
Fibrous1
- Other less common types of bone cancer include: Chondrosarcoma (a cancer arising in cartilage cells, usually found in adults between ages 50-75, though the less common mesenchymal-chondrosarcoma is more frequent in younger patients), Malignant Fibrous Histiocytoma of bone (MFH), Chondoma (a rare low grade malignancy occuring mostly between ages 30 -70), and other rare tumours. (cancerindex.org)
Treat chondrosarcoma2
CD992
- The mesenchymal component often exhibits a haemangiopericytic pattern with multiple vascular spaces ( Figure 4 ).The tumour cells were immunohistochemically reactive for CD99 and negative for S100. (scielo.org.za)
- CD99 reactivity in mesenchymal chondrosarcoma. (semanticscholar.org)
Variant4
- Rare variant of chondrosarcoma . (librepathology.org)
- There are two different categories of chondrosarcomas - classic chondrosarcomas and variant chondrosarcomas. (encyclopedia.com)
- Mesenchymal chondrosarcoma is another rare variant. (encyclopedia.com)
- Mesenchymal chondrosarcoma (MSC) is a rare variant of chondrosarcoma. (clinorthop.org)
Occur3
- Although there are exceptions, chondrosarcomas occur mainly in older adults forty to sixty years old and typically occur more in men than in women. (encyclopedia.com)
- Chondrosarcoma can occur in the arms, legs, or the trunk of the body. (pennmedicine.org)
- Chondrosarcomas most often occur in males. (thefreedictionary.com)
Pelvis3
- Most chondrosarcomas develop in the pelvis, legs or arms. (wikipedia.org)
- It is used to treat a chondrosarcoma in the bones of the skull or spine, as well as in the arm, leg and pelvis. (cancer.ca)
- Chondrosarcoma is considered as a common primary bone sarcoma, which is ranked as the third primary bone malignancy One in five cases of bone sarcomas are due to chondrosarcoma , and half of all cases affect the pelvis (1). (thefreedictionary.com)
Carcinoma3
- We report a case of primary mesenchymal chondrosarcoma occurring in the left kidney with an ipsilateral and distinct distal ureteric implant, and a coexisting infiltrating urothelial carcinoma of the ureter in a 64-year-old man. (biomedcentral.com)
- Multitarget fluorescence in situ hybridization (FISH) suggested that the development of the urothelial carcinoma in the ureter may be triggered or induced by the chondrosarcoma component. (biomedcentral.com)
- This is the first reported case of a primary mesenchymal chondrosarcoma of the kidney with coexisting infiltrating urothelial carcinoma of the ureter. (biomedcentral.com)