Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Chondrosarcoma, Mesenchymal
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
Chondroma
Chordoma
Myxosarcoma
Cartilage
Skull Base Neoplasms
Exostoses, Multiple Hereditary
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms, Connective and Soft Tissue
Osteosarcoma
Ribs
Pelvic Bones
Chondroitinases and Chondroitin Lyases
Chondromatosis, Synovial
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Osteochondroma
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
MedlinePlus
Isocitrate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Peroxisomes
Isocitrate Lyase
National Library of Medicine (U.S.)
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Inhibitory effects of transforming growth factor-beta1 pretreatment on experimental pulmonary metastasis of MCS-1 Chinese hamster mesenchymal chondrosarcoma cells. (1/35)
Recent studies have suggested that transforming growth factor(TGF)-beta1 acts as a multifunctional regulator of cell growth, and also modifies tumor progression and metastasis. In the present study, we investigated the effects of TGF-beta1 on the proliferation and experimental pulmonary metastasis of MCS-1. MCS-1 are undifferentiated type cloned tumor cells established from a mesenchymal chondrosarcoma which spontaneously occurred in the soft tissue of a female Chinese hamster. MCS-1 cells were pretreated with TGF-beta1 (0, 0.05, 0.5, 2, 10 ng/ml) for 72 hours in a medium containing 1% fetal bovine serum, then tested for in vitro growth by the MTT method, in vivo growth by subcutaneous inoculation into athymic nude mice (1 x 10(6) cells/mouse) and experimental pulmonary metastasis by injection into the lateral tail vein of athymic nude mice (5 x 10(4) cells/mouse). TGF-beta1 significantly inhibited in vitro growth of MCS-1, depending on its concentrations, and also experimental metastasis with maximal inhibition at 0.5 or 2 ng/ml treatment compared to untreated controls. TGF-beta1, however, was ineffective for in vivo subcutaneous growth of MCS-1. These results indicated that TGF-beta1 might be an inhibitor of metastasis of mesenchymal chondrosarcomas including other types of non-epitherial cartilage or bone formation tumors. (+info)Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. (2/35)
Mesenchymal chondrosarcomas are small-cell malignancies named as chondrosarcomas due to the focal appearance of cartilage islands. In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms. We were able to trace all steps of chondrogenesis within mesenchymal chondrosarcoma by using characteristic marker genes of chondrocytic development. Starting from undifferentiated cells, which were negative for vimentin and any other mesenchymal marker, a substantial portion of the cellular (undifferentiated) tumor areas showed a chondroprogenitor phenotype with an onset of expression of vimentin and collagen type IIA. Cells in the chondroid areas showed the full expression panel of mature chondrocytes including type X collagen indicating focal hypertrophic differentiation of the neoplastic chondrocytes. Finally, evidence was found for transdifferentiation of the neoplastic chondrocytes to osteoblast-like cells in areas of neoplastic bone formation. These results establish mesenchymal chondrosarcoma as the very neoplasm of differentiating premesenchymal chondroprogenitor cells. The potential of neoplastic bone formation in mesenchymal chondrosarcoma introduces a new concept of neoplastic (chondrocytic) osteogenesis in musculoskeletal malignant neoplasms, which qualifies the old dogma that neoplastic bone/osteoid formation automatically implies the diagnosis of osteosarcoma. (+info)Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (3/35)
The level of prostaglandin D synthase (PGDS), a major protein constituent of cerebrospinal fluid (CSF), is altered in various brain diseases, including meningitis. However, its role in the brain remains unclear. PGDS is mainly synthesized in the arachnoid cells, the choroid plexus and oligodendrocytes in the central nervous system. Among brain tumors, meningiomas showed intense immunoreactivity to PGDS in the perinuclear region. Thus, PGDS has been considered a specific cell marker of meningioma. In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%). Except for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PGDS. Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. These findings suggest that meningeal HPCs may have a unique molecular phenotype that is distinct from that of the soft-tissue HPCs. The origin of meningeal HPCs may be more closely related to the arachnoid cells. (+info)Chondrosarcoma of bone: an oncological and functional follow-up study. (4/35)
We retrospectively analysed the course of 42 out of 45 patients suffering from different chondrosarcomas which were treated surgically. We found a prospective 5- and 10-year survival of 64% for both time intervals. Follow-up examination was possible in 21 of 45 patients. Most of them were staged as NED, one as AWD, and 8 of 45 were lost to follow-up. From 16 dead patients 12 died of the disease and 4 of unknown but not to tumor related reasons. Survival was depending significantly on the histopathological grade, and the stage according to Enneking's surgical staging system. Eleven out of forty-five patients developed metastases within a mean period of twelve months after surgery. The survival of these patients was significantly reduced. Patients with centrally located tumors exhibited a distinct but non-significant worse survival than those suffering from peripheral tumors. In 18% (8 of 45) recurrence of the tumor was evident within a mean period of 24 months (5-85). Functional evaluation was performed in 21 out of 28 alive patients. After a mean follow-up time of 72 months the mean score was 64% (23-100). Females exhibited a distinct but non-significant better result, the same was observed for peripheral locations compared to centrally located tumors. Regarding age, grade, and line of resection no tendency of any dependence was detected, but worst results were seen in those with a stage III tumor and dedifferentiated CS. (+info)Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. (5/35)
Cytogenetic studies of mesenchymal chondrosarcoma are few and to date, no specific or recurrent aberrations have been found. In this investigation, the cytogenetic and molecular cytogenetic (spectral karyotypic and fluorescence in situ hybridization) findings for two mesenchymal chondrosarcomas, one arising skeletally and the other extraskeletally, are reported. An identical Robertsonian translocation involving chromosomes 13 and 21 [der(13;21)(q10;q10)] was detected in both cases, possibly representing a characteristic rearrangement for this histopathologic entity. Both cases also exhibited loss of all or a portion of chromosomes 8 and 20 and gain of all or a portion of chromosome 12. The observation of similar chromosomal abnormalities in both skeletal and extraskeletal mesenchymal chondrosarcoma supports a genetic as well as histopathologic relationship between these anatomically distinct neoplasms. (+info)Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. (6/35)
A young adult female Mastiff dog developed a large retroperitoneal mass, pleural effusion, and multiple pulmonary and pleural nodules. All masses were diagnosed as mesenchymal subtype chondrosarcomas, using histological and immunohistochemical criteria. Reports of canine extraskeletal mesenchymal chondrosarcomas (EMCs) are rare but involved animals less than 3 years of age in 60% of the cases. This is the first description of this type of tumor developing distant metastases. Evidence from this case and previous reports suggests that EMCs are associated with a poor prognosis. (+info)Mesenchymal chondrosarcoma originating from the femoral vein. (7/35)
Mesenchymal chondrosarcoma is a rare variant of chondrosarcomas characterized by a bimorphic pattern with areas of the undifferentiated malignant small cells and well differentiated cartilaginous islands.(1) It occurs most commonly in the bone but can also occur in the extraskeletal soft tissues, the brain, and the meninges. This type of tumor has also been described in the eyelids, parapharyngeal space, mediastinum, and the kidney.(1-5) An origin from the large vessels has not been reported in the medical literature. The authors report a case of mesenchymal chondrosarcoma originating from the femoral vein in a 28-year-old female patient, treated by the wide-margin resection. (+info)Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. (8/35)
BACKGROUND: Mesenchymal chondrosarcoma (MC) is an infrequent neoplasm, representing approximately 1% of all chondrosarcomas. Cytologic descriptions of MCs have been confined to rare case reports. In the current report, the authors describe their experience with the cytologic features of four MCs: two primary tumors and two metastatic lesions. METHODS: Four patients were diagnosed with MC at the authors' institution from 1994 to 2002. Three of four patients underwent fine-needle aspiration (FNA) biopsy as part of their diagnosis; in the fourth patient, imprint cytology was performed. Each tumor also received histologic confirmation. RESULTS: The patients studied included three females and one male. In three patients, the tumor presented initially as a soft tissue mass; whereas, in the remaining patient, the MC presented in the tibia. FNA results demonstrated small, oval-to-spindled cells with high nuclear-to-cytoplasmic ratios. Cells occurred singly and in clumps in a background of basophilic extracellular matrix. Histologic examination of each lesion demonstrated biphasic tumors, including focal areas of relatively mature cartilage formation as well as a small cell population. CONCLUSIONS: MC is a rare soft tissue tumor that occurs frequently in extraskeletal locations. FNA of these tumors can be diagnostic if the tumor is sampled appropriately and of critical features, such as the background extracellular matrix, are recognized. Given the propensity of these tumors to metastasize and the poor prognosis of patients with MC, early identification by FNA biopsy may allow earlier, more aggressive interventions. (+info)Intracranial extraskeletal mesenchymal chondrosarcoma: Case report<...
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case | Journal of Orthopaedic Case Reports
Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis | springermedizin.at
Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature | BMC Cancer | Full Text
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Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
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chondrosarcoma in dogs skull
NewYork-Presbyterian Queens - Chondrosarcoma
NewYork-Presbyterian Queens - Chondrosarcoma
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma...
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Chondrosarcoma: Causes, Symptoms, Diagnosis and Treatment
Chondrosarcoma
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Polarity and Ploidy in Peripheral Chondrosarcoma Research Grant
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Chondrosarcoma | Coliseum Health System
GLC cancer
Mca June 2011 Exam Paper - 442 Words
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IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...
Functional genomic analyses of the impact of global hypomethylation an by Christopher Allan Hamm
Chondrosarcoma: Its treatment by radiation, hyperthermia and bleomycin<...
Chondrosarcoma
Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma
Chondrosarcoma of the greater cornu of the hyoid: a case report and literature review.
An extraskeletal chondrosarcoma of the maxilla. A case report<...
Chondrosarcoma of the Thorax - Semantic Scholar
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Other shared propranolol examen oral
Dedifferentiated chondrosarcomas of the larynx: a report of two cases and review of the literature
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
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MedPix Case - chondrosarcoma, low grade
Chondrosarcoma treatment in clinics of Kleinbartloff, prices, patient reviews - DocLandmed
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My Results are in ~ Its Cancer - Shizzle Design
Bone sarcoma
Clear cell Clear cell chondrosarcomas are rare, slow-growing, and seldom spread. Mesenchymal Mesenchymal chondrosarcomas can ... "Mesenchymal chondrosarcoma , Radiology Reference Article , Radiopaedia.org". Radiopaedia. Müller S, Söder S, Oliveira AM, ... Most chondrosarcomas develop in the pelvis, legs or arms. Benign counterparts are known as enchondromas. Chondrosarcomas are ... "Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton". Mod ...
Chondrosarcoma
IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal ... CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma". The Lecturio Medical Concept Library. Retrieved 8 ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ... Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there ...
IRF2BP2 (gene)
... in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC ...
Randy Miller (musician)
Miller was diagnosed with mesenchymal chondrosarcoma, a form of bone cancer, in 2008, the same year that With Arrows, With ...
Extraskeletal myxoid chondrosarcoma
... (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ... "Myxoid Chondrosarcoma - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-02-04. "TAF15 TATA-box ... when they discussed the different species of extraskeletal chondrosarcoma, but EMC concept was firstly proposed in 1972 by ... Yang, Lei; Qin, Genggeng; Xu, Rong; Wang, Ruoning; Zhang, Ling (2018). "Extraskeletal Myxoid Chondrosarcoma: A Comparative ...
Cancer epigenetics
Expression of epigenetic modifiers such as that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcoma, ... Sarcomas comprise a large number of rare, histogenetically heterogeneous mesenchymal tumors that, for example, include ... Similarly, expression of another epigenetic modifier, the LSD1 histone demethylase, is increased in chondrosarcoma, Ewing's ... Bennani-Baiti IM (December 2011). "Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis ...
Sclerosing epithelioid fibrosarcoma
... been mistaken for rare types of other sarcomas that sometimes have epithelioid features such as mesenchymal chondrosarcomas, ... Du W, Liu X, Yang M, Wang W, Sun J (2021). "The Regulatory Role of PRRX1 in Cancer Epithelial-Mesenchymal Transition". ... the PRRX1 gene product protein regulates epithelial-mesenchymal transition and may be involved in the development of various ...
List of MeSH codes (C04)
... chondrosarcoma MeSH C04.557.450.565.280.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.565.380 - giant cell tumors MeSH ... chondrosarcoma MeSH C04.557.450.795.300.280 - chondrosarcoma, mesenchymal MeSH C04.557.450.795.350 - fibrosarcoma MeSH C04.557. ...
Small-blue-round-cell tumor
... the more common fetal and embryonal types do not Merkel cell carcinoma Mesenchymal chondrosarcoma Endometrial stromal ...
WHO classification of tumours of the central nervous system
Ewing sarcoma 7.2 Chondro-osseous tumours 7.2.1 Chondrogenic tumours 7.2.1.1 Mesenchymal chondrosarcoma 7.2.1.2 Chondrosarcoma ... 7.1.3 Skeletal muscle tumours 7.1.3.1 Rhabdomyosarcoma 7.1.4 Uncertain differentiation 7.1.4.1 Intracranial mesenchymal tumour ...
International Classification of Diseases for Oncology
Myxoid chondrosarcoma M9240/3 Mesenchymal chondrosarcoma M9241/0 Chondromyxoid fibroma M9242/3 Clear cell chondrosarcoma M9243/ ... NOS Mixed mesenchymal tumor M8990/3 Mesenchymoma, malignant Mixed mesenchymal sarcoma M8991/3 Embryonal sarcoma M9000/0 Brenner ... M9221/0 Juxtacortical chondroma Periosteal chondroma M9221/3 Juxtacortical chondrosarcoma Periosteal chondrosarcoma M9230/0 ... 3 Dedifferentiated chondrosarcoma M9250/1 giant cell tumor of bone, NOS Osteoclastoma, NOS M9250/3 Giant cell tumor of bone, ...
Sarcoma
Yang J, Ren Z, Du X, Hao M, Zhou W (27 October 2014). "The role of mesenchymal stem/progenitor cells in sarcoma: update and ... Some sarcomas, such as leiomyosarcoma, chondrosarcoma, and gastrointestinal stromal tumor (GIST), are more common in adults ... A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. ... These subtypes are as follows: Osteosarcoma Chondrosarcoma Poorly differentiated round/spindle cell tumors (includes Ewing ...
Index of trauma and orthopaedics articles
Mesenchymal chondrosarcoma - Metaphysis - Metatarsophalangeal joint sprain - Microfracture surgery - Milch classification - ... Myxoid chondrosarcoma National hip fracture database - Neer classification - Neer impingement sign - Neer's prosthesis - ... Chondrosarcoma - Chopart's fracture-dislocation - Clarke's test - Clavicle fracture - Clay-shoveler fracture - Cleidocranial ...
Chondroblast
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... As suggested in the name, mesenchymal progenitors originate from the mesoderm. These cells, when forming from the mesoderm, ... Day, Timothy F.; Guo, Xizhi; Garrett-Beal, Lisa; Yang, Yingzi (2005). "Wnt/β-Catenin Signaling in Mesenchymal Progenitors ... Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ...
IFFO1
However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... especially mesenchymal cells. The vimentin protein is also responsible for maintaining cell shape, integrity of the cytoplasm, ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...
Benign tumor
Failure to stop growth can be indicative of transformation to malignant chondrosarcoma. Treatment is not indicated unless ... characteristics of the neoplastic cells causing giant cell tumors of bone indicate an origin of pluripotent mesenchymal stem ...
Bone tumor
... such as chondrosarcoma). There is a variety of chemotherapy treatment protocols for bone tumors. The protocol with the best- ... other mesenchymal tumors of bone, and hematopoietic neoplasms of bone. Bone tumors may be classified as "primary tumors", which ... chondrosarcoma, Ewing's sarcoma, fibrosarcoma, and other types. While malignant fibrous histiocytoma (MFH) - now generally ...
Metaphysis
The metaphysis contains a diverse population of cells including mesenchymal stem cells, which give rise to bone and fat cells, ... Metaphyseal tumors or lesions include osteosarcoma, chondrosarcoma, fibrosarcoma, osteoblastoma, enchondroma, fibrous dysplasia ...
FET protein family
"Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal ... Extraskeletal myxoid chondrosarcoma: These tumors' neoplastic cells express the EWSR1-NR4A3 fusion gene in most cases or the ... Intracranial mesenchymal tumors with FET‐CREB fusions: These tumors are suggested to be a variant of the angiomatoid fibrous ...
Ectomesenchymal chondromyxoid tumor
... mesenchymal cells. There are some who think it is a myoepithelial tumor type. Derived from ectomesenchymal cells migrating from ... extraskeletal myxoid chondrosarcoma, focal oral mucinosis, and an ossifying fibromyxoid tumor of soft parts. Exceedingly rare, ...
List of cancer types
Chondrosarcoma Ewing's sarcoma Malignant fibrous histiocytoma of bone/osteosarcoma Osteosarcoma Rhabdomyosarcoma Leiomyosarcoma ... each of which develop from cells originating in mesenchymal cells outside of the bone marrow. Lymphoma and leukemia: These two ...
Chondroblastoma
Romeo et al have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal ... clear cell chondrosarcomas, and enchondromas (this list is not exhaustive). Chondroblastoma has not been known to spontaneously ... These findings suggest that chondroblastoma is derived from a mesenchymal cell undergoing chondrogenesis via active growth- ... any definitive determinations regarding the origin of this neoplasm are not possible because of the plasticity of mesenchymal ...
Low-grade fibromyxoid sarcoma
LGFMS can be difficult to distinguish from other mesenchymal tumors, particularly from sclerosing epithelioid fibrosarcoma (SEF ... extraskeletal myxoid chondrosarcoma, synovial sarcomas that have a prominent myxoid background, or myxoid liposarcoma. However ...
List of OMIM disorder codes
GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... RSPO4 Anterior segment mesenchymal dysgenesis; 107250; FOXE3 Anterior segment mesenchymal dysgenesis; 107250; PITX3 ... 612237; TFG Chondrosarcoma, extraskeletal myxoid; 612237; CSMF Chorea, hereditary benign; 118700; NKX2-1 Choreoacanthocytosis; ...
Osteosarcoma
Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and ... Differential diagnosis of the osteosarcoma of the skull in particular includes, among others, chondrosarcoma and the ...
Index of oncology articles
... chondrosarcoma - chordoma - chorioallantoic membrane - choriocarcinoma - choroid plexus tumor - CHPP - chronic granulocytic ... mesenchymal - mesenteric membrane - mesna - mesonephroma - mesothelioma - metaplasia - metaplastic carcinoma - metastasectomy ...
TBX3
Volckaert T, De Langhe SP (March 2015). "Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development". ... chondrosarcoma, fibrosarcoma, liposarcoma, rhabdomyosarcoma and synovial sarcoma) and there is compelling evidence that it ...
Rhabdomyosarcoma
... (RMS) is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully ... chondrosarcoma, or angiosarcoma". The American Journal of Surgical Pathology. 26 (9): 1175-1183. doi:10.1097/00000478-200209000 ...
Mesenchymal Chondrosarcoma Map | Find people with Mesenchymal Chondrosarcoma in the map
Mesenchymal Chondrosarcoma - JTV
Is there progress in the treatment of high-risk myeloma? | springermedizin.at
Mesenchymal stem cells preconditioned with myeloma cells from high-risk patients support the growth of myeloma cells from low- ... Mesenchymal stem cells preconditioned with myeloma cells from high-risk patients support the growth of myeloma cells from low- ... Signatures of mesenchymal cell lineages and microenvironment factors are dysregulated in high risk myeloma. Blood. 2016;128(22 ... Signatures of mesenchymal cell lineages and microenvironment factors are dysregulated in high risk myeloma. Blood. 2016;128(22 ...
Benign and Malignant Soft-Tissue Tumors Workup: Laboratory Studies, Imaging Studies, Tissue Diagnosis
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. - PDF Download Free
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report.. Arthroscopic fixation of ... Congenital sacral mesenchymal chondrosarcoma in a neonate: a case report and review of literature.. ... Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. ... Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report.. ...
Mesenchymal Chondrosarcoma of Posterior Maxilla: Report of a Case with Brief Literature Review
Mesenchymal chondrosarcomas (MCs) are infrequent, slowâ  growing malignant tumors of head and neck region affecting both bone ... Mesenchymal Chondrosarcoma of Posterior Maxilla: Report of a Case with Brief Literature Review. Author(s): Kumar MCD, Suresh KV ... Mesenchymal chondrosarcomas (MCs) are infrequent, slowâ growing malignant tumors of head and neck region affecting both bone ... It represents approximately 1% of all chondrosarcomas. They usually occur in the middle aged individuals, but rarely seen in ...
Chondrosarcoma: Practice Essentials, Background, Pathophysiology
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... Mesenchymal chondrosarcoma. The 5-year survival rate for mesenchymal chondrosarcoma is less than 50%, with an overall 10-year ... Fewer than 2% of all chondrosarcomas are mesenchymal chondrosarcomas. The maxilla and the mandible are the most common sites of ... Chondrosarcoma is a tumor of mesenchymal origin that predominantly is made of cartilage; it is the second most common primary ...
A mesenchymal chondrosarcoma of the right tibia in a young man requires disarticulation of the right knee: A case study | OJOR
Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version
Rui Kishimoto - Articles - Scientific Research Publishing
Condrosarcoma mixoide extraóseo: Caracterización por resonancia magnética
Chondrosarcoma including spindle cell and myxoid chondrosarcoma: mesenchymal chondrosarcoma. Bone tumors: diagnosis, treatment ... Chondrosarcoma. Different variants of chondrosarcoma. Revista Espa ola de Patolog a 2006; 39(2): 69-79. ... Extraskeletal myxoid chondrosarcoma. Enzinger and Weiss s Soft Tissue Tumors. St Louis: Mosby; 2001: 1368-79. ... Varma DGK, Ayala AG, Carrasco CH, Shan-Qun G, Kumar R, Edeiken J. Chondrosarcoma: MR Imaging with pathologic. RadioGraphics ...
Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial - The Lancet...
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal ... Extraskeletal myxoid chondrosarcoma. Long-term experience with chemotherapy.. Am J Clin Oncol. 1995; 18: 161-163. View in ... Activity of sunitinib in extraskeletal myxoid chondrosarcoma.. Eur J Cancer. 2014; 50: 1657-1664. View in Article *Scopus (50) ... Extraskeletal myxoid chondrosarcoma.. in: Fletcher CD Bridge JA Hogendoorn PCW Mertens F WHO classification of tumours of soft ...
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Sarcoma
Mesenchymal tumor, malignant, Malignant mesenchymal tumor, Malignant mesenchymal tumour, Malignant tumor of soft tissue, ... Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.. Definition (NCI_CDISC). A malignant ... A malignant mesenchymal tumor for which a distinct line of differentiation cannot be determined. This term may be used for ... A malignant mesenchymal neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive ...
Find Research outputs - Manipal Academy of Higher Education, Manipal, India
Survival from rare bone cancer remains low
IDH1 gene: MedlinePlus Genetics
Anupama Grandhi, BDS, DDS - Presentations | Loma Linda University
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Morphologic diagnosis: aortic chondrosarcoma.. Case summary: primary aortic chondrosarcoma affecting cranial and caudal ( ... CSA generally consists of lobules of mesenchymal cells producing variable quantities of disorganized hyaline cartilage or ... Dedifferentiated chondrosarcoma in the dog and cat: a case series and review of the literature. J Am Anim Hosp Assoc. 2018;54: ... Dedifferentiated chondrosarcoma in the dog and cat: a case series and review of the literature. J Am Anim Hosp Assoc. 2018;54: ...
Deciphering the effects of IDH mutations on chromatin and differentiation in chondrosarcoma
... data presented in this proposal demonstrates that IDH mutations impair the differentiation of untransformed mesenchymal ... Deciphering the effects of IDH mutations on chromatin and differentiation in chondrosarcoma. Juan Manuel Schvartzman, MD, PhD, ... IDH mutations are seen in 50% of chondrosarcomas, which represent approximately 25% of malignant bone neoplasms. The oncogenic ... and on-treatment samples of locally advanced IDH-mutant chondrosarcoma patients treated with an IDH1-mutant inhibitor to study ...
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NFATp represses chondrogenesis | Arthritis Research & Therapy | Full Text
DeCS
Chondrosarcomas, Mesenchymal. Mesenchymal Chondrosarcoma. Mesenchymal Chondrosarcomas. Tree number(s):. C04.557.450.565.280.280 ... Chondrosarcoma, Mesenchymal - Preferred Concept UI. M0027440. Scope note. A rare aggressive variant of chondrosarcoma, ... Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in ... Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in ...
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TMA Master publication list | 3DHISTECH Ltd.
A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a ... ... 2013). Screening for Potential Targets for Therapy in Mesenchymal, Clear Cell, and Dedifferentiated Chondrosarcoma Reveals Bcl- ... A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a ... Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen ...
OsteosarcomaTumorsTumorDiagnosisConventional chondrosarcomaTypes of chondrosarcomaPeriostealSpindle cellSARCOMABenignMetastaticNeoplasmsOccurDifferentiationImmunohistochemistrySecondaryNCOA2RemnantsPrimaryTypicallyLesionAggressiveImagingTissueSkull baseStemPoorlyRareTransformationCase ReportSoft tissues
Osteosarcoma3
- Chondrosarcoma is a malignant tumor occupying the 2nd position in terms of frequency, all ages combined, after osteosarcoma [1]. (peertechzpublications.com)
- With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
- Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone exceeded only by myeloma and osteosarcoma. (biomedcentral.com)
Tumors13
- Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
- Mesenchymal chondrosarcomas (MCs) are infrequent, slowâ growing malignant tumors of head and neck region affecting both bone and soft tissues. (amhsr.org)
- Somatic mutations in the IDH1 gene have been associated with several other forms of cancer, including brain tumors called gliomas and bone tumors known as chondrosarcomas. (medlineplus.gov)
- These proposed studies will lead to an enhanced understanding of how metabolic enzyme mutations impair differentiation in chondrosarcomas and unlock the potential of differentiation therapy in solid tumors, a long-sought hurdle of cancer treatment. (curesarcoma.org)
- Chondrosarcoma is a member of this group, as this is the tumors of cartilage producing cells. (alwaysayurveda.net)
- Chondrosarcomas are a group of tumors with highly diverse features and behavior patterns, ranging from slow-growing nonmetastasizing lesions to highly aggressive metastasizing sarcomas. (medscape.com)
- Primary (conventional) chondrosarcomas (85-90%) occur in preexisting normal bone, whereas secondary tumors occur in preexisting enchondromas and osteochondromas. (medscape.com)
- The imaging appearances of chondrosarcoma may overlap with those of other lesions, especially other cartilaginous tumors such as enchondroma. (medscape.com)
- Chondrosarcomas are malignant cartilage-forming bone tumors, which are intrinsically resistant to chemo- and radiotherapy, leaving surgical removal as the only curative treatment option. (csfshayna.org)
- Sensitivity to YM155, a survivin inhibitor currently in phase I/II clinical trial for other tumors, was examined in 10 chondrosarcoma cell lines using viability assay, apoptosis assay and cell-cycle analysis. (csfshayna.org)
- Chondrosarcoma is a malignant cartilage-forming tumor accounting for 20% of all malignant bone tumors. (csfshayna.org)
- patients with atypical cartilaginous tumors show a 10-year overall survival rate of 83%, patients with grade II tumors show 64% survival and patients with grade III chondrosarcomas show 29% 10-year survival rate.1,2 Dedifferentiated chondrosarcomas comprise 10% of all chondrosarcomas and are characterized by a high-grade dedifferentiated component juxtaposed to a low-grade cartilaginous component. (csfshayna.org)
- Of all chondrogenic tumors, 28.5% are osteochondroma, 29.1% enchondroma, 21.7% conventional chondrosarcoma grade I-III, less than 5% are subungual exostosis and bizarre parosteal osteochondromatous proliferation combined, and the least common is mesenchymal chondrosarcoma at less than 1%, as reported by the WHO in 2020. (mdwiki.org)
Tumor7
- A malignant mesenchymal tumor for which a distinct line of differentiation cannot be determined. (fpnotebook.com)
- Chondrosarcoma is the second most frequent primary malignant tumor of bone, representing approximately 20-25% of all primary osseous neoplasms. (medscape.com)
- Chondrosarcomas are intrinsically resistant to conventional chemo- and radiotherapy, and therefore surgical removal of the tumor is the only curative treatment option. (csfshayna.org)
- In the latest version of the guidelines released in November 2020, surgery is the main treatment for chondrosarcoma, chordoma, and giant cell tumor of bone, which can be combined with radiotherapy or targeted therapy. (bvsalud.org)
- Phase study of the tumor mutational burdenTtmb mutant IDH1 inhibitor ivosidenib: Safety and clinical activity in patients with advanced chondrosarcoma. (bvsalud.org)
- [1] Distinguishing a large non-cancerous cartilage tumor, such as an enchondroma, from a chondrosarcoma grade I or atypical cartilaginous tumour is difficult. (mdwiki.org)
- Although dedifferentiation in a chondrosarcoma was strongly considered, the pattern was considered unusual and the possibility of a collision tumor (enchondroma with desmoplastic fibroma) was also entertained, with recommended treatment to achieve control of a locally aggressive neoplasm. (biomedscis.com)
Diagnosis3
- Imaging studies and biopsy help you to confirm your diagnosis on chondrosarcoma. (alwaysayurveda.net)
- Final diagnosis was based on histological examination, which confirmed the hypothesis of low-grade parafalcine chondrosarcoma. (neoplasiaresearch.com)
- A differential diagnosis of chondrosarcoma should be considered because of the life-threatening features of chondrosarcoma. (bvsalud.org)
Conventional chondrosarcoma1
- [1] Osteochondroma and enchondroma are the most common non-cancerous types, and conventional chondrosarcoma is the most common cancerous type. (mdwiki.org)
Types of chondrosarcoma1
- Types of Chondrosarcoma and the classification is based on their look under microscope. (alwaysayurveda.net)
Periosteal2
- Primary chondrosarcomas are divided into central, periosteal, and peripheral types. (medscape.com)
- A grade 2 periosteal chondrosarcoma in the humeral shaft. (radiologykey.com)
Spindle cell3
- Chondrosarcoma including spindle cell and myxoid chondrosarcoma: mesenchymal chondrosarcoma. (medigraphic.com)
- The morphologic features are distinct from other sarcomas associated with NCOA2 gene fusions, including mesenchymal chondrosarcoma, congenital/infantile spindle cell rhabdomyosarcoma, and soft tissue angiofibroma. (elsevier.com)
- The procedure was performed under image intensifier control and the histological picture of the specimen showed features of a dedifferentiated lowgrade chondrosarcoma with abrupt demarcation between a distinct cartilaginous component and a spindle cell component. (biomedscis.com)
SARCOMA2
- In June 2016 I was diagnosed with a rare and now discovered incurable sarcoma cancer called Mesenchymal Chondrosarcoma. (theactiveamputee.org)
- Dedifferentiation of a low-grade chondrosarcoma is thought to occur when a high-grade sarcoma develops within the locally aggressive lesion [1]. (biomedscis.com)
Benign4
- Benign cartilage lesions can be difficult to differentiate from slow-growing, low-grade chondrosarcomas. (medscape.com)
- Secondary chondrosarcoma can occur in a previously benign cartilaginous lesion. (medscape.com)
- Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone and can be primary or secondary, the latter results mainly from the malignant transformation of a benign pre-existing tumour. (biomedcentral.com)
- First described by Nora et al [ 1 ] in 1983, it is a rare, benign, reactive mineralizing mesenchymal lesion with less than 200 cases reported in the literature. (medscape.com)
Metastatic1
- Therefore, there is still an urgent need for novel therapeutic targets that can be easily and rapidly applied in the treatment of patients with high-grade metastatic or inoperable chondrosarcoma. (csfshayna.org)
Neoplasms1
- IDH mutations are seen in 50% of chondrosarcomas, which represent approximately 25% of malignant bone neoplasms. (curesarcoma.org)
Occur1
- Less than 7% of chondrosarcomas occur in patients younger than 21 years. (medscape.com)
Differentiation3
- Preliminary data presented in this proposal demonstrates that IDH mutations impair the differentiation of untransformed mesenchymal progenitor cells by inhibiting the removal of a repressive chromatin mark (H3K9me2/me3) in genomic regions required for differentiation. (curesarcoma.org)
- and 2) analyzing pre- and on-treatment samples of locally advanced IDH-mutant chondrosarcoma patients treated with an IDH1-mutant inhibitor to study the consequences of IDH1-mutant inhibition on transcription (RNA-seq), chromatin (ATAC-seq and ChIP-seq) and differentiation. (curesarcoma.org)
- Differentiation of human mesenchymal stem cells in vitro resulted in induction of NFATp mRNA under chondrogenic conditions but not under conditions which initiate osteogenesis. (biomedcentral.com)
Immunohistochemistry1
- Using immunohistochemistry, nuclear as well as cytoplasmic survivin expression was analyzed in 207 chondrosarcomas of different subtypes. (csfshayna.org)
Secondary2
- Secondary chondrosarcomas include clear cell, mesenchymal, and dedifferentiated chondrosarcomas. (medscape.com)
- MRI is useful in evaluating the thickened cartilage cap in an osteochondroma in which a secondary chondrosarcoma develops. (medscape.com)
NCOA21
- NCOA2 fusion that is distinct from mesenchymal chondrosarcoma. (bvsalud.org)
Remnants2
- These tumours arise from either notochordal remnants or mesenchymal cells. (biomedcentral.com)
- SC is a cartilaginous metaplasia of the mesenchymal remnants of the synovial tissue of the joints. (bvsalud.org)
Primary1
- Chondrosarcomas are known to be the third most common malignant tumour occurring in bone and constitutes approximately 20% of primary bone sarcomas [3]. (biomedscis.com)
Typically3
- Chondrosarcomas typically present in adults during the fifth to seventh decades and are rare in young patients. (medscape.com)
- Chondrosarcoma is a cartilage forming tumour, typically found in flat bones such as the ilium. (biomedscis.com)
- Dedifferentiated chondrosarcoma typically has 2 microscopic components, whereby the low-grade cartilaginous lesion is seen with a high grade sarcomatous component with an abrupt transition between the 2 zones [1]. (biomedscis.com)
Lesion1
- Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
Aggressive2
- A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. (bvsalud.org)
- Even though surgery remains the mainstay of treatment for cerebral chondrosarcomas, adjuvant radiotherapy such as stereotactic, proton beam or carbon ion-beam therapy might be necessary in aggressive or incomplete removed cases. (neoplasiaresearch.com)
Imaging1
- Kothary N, Law M, Cha S, Zagzag D. Conventional and Perfusion MR Imaging of Parafalcine Chondrosarcoma. (neoplasiaresearch.com)
Tissue2
- A malignant mesenchymal neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones. (fpnotebook.com)
- They can arise from mesenchymal tissue at any body site. (apollohospitals.com)
Skull base3
- This study presents an analysis (efficacy and toxicity) of outcomes in patients with skull-base chordomas or chondrosarcomas treated with a fixed horizontal pencil proton beam. (biomedcentral.com)
- Treatment with a fixed proton beam shows promising disease control and an acceptable toxicity rate, even the difficult-to-treat subpopulation of patients with skull-base chordomas or chondrosarcomas requiring dose escalation. (biomedcentral.com)
- Chordomas and chondrosarcomas are rare among malignancies and mainly affect the skull base, sacrum bones, and vertebral column (less). (biomedcentral.com)
Stem1
- A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target. (3dhistech.com)
Poorly1
- We report a case of a 38 year male with a large and poorly symptomatic parafalcine chondrosarcoma of the cranial vault which was removed en bloc. (neoplasiaresearch.com)
Rare3
- Ten-year survival of a rare malignancy called mesenchymal chondrosarcoma has been reported to be as low as 20 percent. (medworm.com)
- Chordomas (CAs) and chondrosarcomas (CSAs) are rare tumours that are usually located near the base of the skull and very close to the brain's most critical structures. (biomedcentral.com)
- Chondrosarcoma is a rare malignant tumour arising from the cartilage with a high variability in the clinicalcourse and overall prognosis. (neoplasiaresearch.com)
Transformation1
- If the cap measures more than 1.5 cm in a skeletally mature patient, transformation to chondrosarcoma may have occurred. (medscape.com)
Case Report4
- Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. (docksci.com)
- Coex stence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hem hyperplas a: A Case Report Nihat Demirhan Demirkiran¹, Olcay Akdeniz¹, Onur Hapa¹, Hasan Havıtçıoğlu¹ What to Learn from this Article? (docksci.com)
- Gunes M, Gunaldi O, Tugcu B, Tanriverdi O, Guler AK, Colluoglu B. Intracranial chondrosarcoma: a case report and review of the literature. (neoplasiaresearch.com)
- Mesenchymal Chondrosarcoma of the Orbit: A case report and review of the literature. (jkos.org)
Soft tissues1
- A malignant mesenchymal neoplasm arising exclusively from the soft tissues. (fpnotebook.com)