Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Chondrosarcoma, Mesenchymal
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
Chondroma
Chordoma
Myxosarcoma
Cartilage
Skull Base Neoplasms
Exostoses, Multiple Hereditary
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms, Connective and Soft Tissue
Osteosarcoma
Ribs
Pelvic Bones
Chondroitinases and Chondroitin Lyases
Chondromatosis, Synovial
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Osteochondroma
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD). (1/542)
Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short times after injection of photosensitizer. Groups of rats with chondrosarcoma were given 2 mg kg(-1) of BPD intravenously 5 min to 180 min before light treatment of 150 J cm(-2) 690 nm. Vascular response was monitored using intravital microscopy and tumour cure was monitored by following regrowth over 42 days. For treatment at 5 or 30 min after BPD injection, blood flow stasis was limited to tumour microvasculature with lesser response in the surrounding normal microvasculature, indicating selective targeting for damage. No acute changes were observed in vessels when light was given 180 min after BPD injection. Tumour regression after light treatment occurred in all animals given PDT with BPD. Long-term tumour regression was greater in animals treated 5 min after BPD injection and least in animals given treatment 180 min after drug injection. The correlation between the timing for vascular damage and cure implies that blood flow stasis plays a significant role in PDT-induced tumour destruction. (+info)The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. (2/542)
The EWS/TEC gene fusion generated by the t(9;22) chromosomal translocation found in extraskeletal myxoid chondrosarcomas encodes a fusion protein containing the amino-terminal domain of the EWS protein fused to the whole coding sequence of the orphan nuclear receptor TEC. We have compared the DNA-binding and transcriptional activation properties of various TEC isoforms and the corresponding EWS/TEC fusion proteins. Band-shift experiments show that the full-length TEC receptor can efficiently bind the NGFI-B Response Element (NBRE), whereas an isoform lacking the entire carboxyl-terminal domain of the receptor binds much less efficiently the NBRE. Addition of the amino-terminal domain of EWS to either isoforms does not alter significantly their DNA-binding properties to the NBRE. Co-transfection experiments of COS cells and human chondrocytes indicate that whereas TEC moderately activates transcription from a NBRE-containing promoter, the corresponding EWS/TEC fusion protein is a highly potent transcriptional activator of the same promoter, being approximately 270-fold more active than the native receptor. EWS/TEC may thus exert its oncogenic potential in chrondrosarcomas by activating the transcription of target genes involved in cell proliferation. (+info)Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (3/542)
We report here the isolation and sulphation isomer analyses of trisaccharides GalNAcS(beta1,4)GlcA(beta1,3)GalNAcS (in which S indicates sulphate) derived from the non-reducing termini of aggrecan chondroitin sulphate. Rat chondrosarcoma and human aggrecans were digested for 1 h at 37 degrees C with 30 micro-units of endo-chondroitinase ABC per microgram of chondroitin sulphate, and trisaccharides were isolated from the digests by ToyoPearl HW40S gel-filtration chromatography. Four trisaccharide species were identified; their sulphation isomer compositions, as determined by digestion with chondroitinase ACII and fluorescence-based ion-exchange HPLC, were GalNAc4Sbeta1,4GlcAbeta1,3GalNAc4S, GalNAc4Sbeta1,4GlcAbeta1,3GalNAc6S, GalNAc4,6Sbeta1,4GlcAbeta1, 3GalNAc4S and GalNAc4,6Sbeta1,4GlcAbeta1,3GalNAc6S. The abundances of such sequences in chondroitin sulphate on aggrecan from normal (foetal to 72 years of age) and from osteoarthritic human knee cartilages were also established. The results showed that non-reducing terminal GalNAc4S or GalNAc4,6S can be linked to either a 4-sulphated or a 6-sulphated disaccharide, suggesting that the sulphation of the last disaccharide might not have a direct effect on the specificity of chondroitin sulphate terminal GalNAc sulphotransferases. Furthermore, for each aggrecan preparation examined, the 4S-to-6S ratio of all chain interior disaccharides was equivalent to that in the last repeating disaccharides at the non-reducing terminus, suggesting that neither chondroitin 4-sulphotransferase nor chondroitin 6-sulphotransferase shows preferential activity near the chain terminus. (+info)EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. (4/542)
Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether inactivation of both alleles of an EXT gene, according to the tumor-suppressor model, is required for osteochondroma development, or whether a single EXT germline mutation acts in a dominant negative way. We therefore studied loss of heterozygosity and DNA ploidy in eight sporadic and six hereditary osteochondromas. EXT1- and EXT2-mutation analysis was performed in a total of 34 sporadic and hereditary osteochondromas and secondary peripheral chondrosarcomas. We demonstrated osteochondroma to be a true neoplasm, since aneuploidy was found in 4 of 10 osteochondromas. Furthermore, LOH was almost exclusively found at the EXT1 locus in 5 of 14 osteochondromas. Four novel constitutional cDNA alterations were detected in exon 1 of EXT1. Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild-type allele in three osteochondromas, indicating that, in cartilaginous cells of the growth plate, inactivation of both copies of the EXT1 gene is required for osteochondroma formation in hereditary cases. In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene. (+info)Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. (5/542)
The sulfurylase domain of the mouse bifunctional enzyme ATP sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains HXXH and PP-loop motifs. To elucidate the functional importance of these motifs and of conserved arginines and histidines, chemical modification and site-directed mutagenesis studies were performed. Chemical modification of arginines and histidines with phenylglyoxal and diethyl pyrocarbonate, respectively, renders the enzyme inactive in sulfurylase, kinase, and overall assays. Data base searches and sequence comparison of bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number of highly conserved arginines and histidines within the sulfurylase domain. Of these conserved residues, His-425, His-428, and Arg-421 are present within or near the HXXH motif whereas His-506, Arg-510, and Arg-522 residues are present in and around the PP-loop. The functional role of these conserved residues was further studied by site-directed mutagenesis. In the HXXH motif, none of the alanine mutants (H425A, H428A, and R421A) had sulfurylase or overall activity, whereas they all exhibited normal kinase activity. A slight improvement in reverse sulfurylase activity (<10% residual activity) and complete restoration of forward sulfurylase was observed with R421K. Mutants designed to probe the PP-loop requirements included H506A, R510A, R522A, R522K, and D523A. Of these, R510A exhibited normal sulfurylase and kinase activity, R522A and R522K showed no sulfurylase activity, and H506A had normal sulfurylase activity but produced an effect on kinase activity (<10% residual activity). The single aspartate, D523A, which is part of the highly conserved GRD sequence of the PP-loop, affected both sulfurylase and kinase activity. This mutational analysis indicates that the HXXH motif plays a role only in the sulfurylase activity, whereas the PP-loop is involved in both sulfurylase and kinase activities. Residues specific for sulfurylase activity have also been distinguished from those involved in kinase activity. (+info)Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. (6/542)
OBJECTIVE: The aim of the study was to investigate the messenger RNA (mRNA) expression of the disintegrin metalloproteinase MDC15 (metargidin, or ADAM-15) in normal and osteoarthritic (OA) articular cartilage. METHODS: In situ hybridization experiments and reverse transcription-polymerase chain reaction (RT-PCR) were performed on tissue samples of adult normal and OA articular cartilage. RESULTS: MDC15 mRNA could be detected in normal articular cartilage by RT-PCR using tissue-extracted total RNA as a template. However, the mRNA level remained below the sensitivity of in situ hybridization. In contrast, in situ hybridizations of OA cartilage revealed an intense staining with the MDC15-specific riboprobes. The extension of the analysis to chondrosarcomas showed a strong up-regulation of MDC15 mRNA in these malignant transformed cells. CONCLUSION: Our results demonstrate a markedly strong up-regulation of MDC15 in adult OA and neoplastic cartilage compared with adult normal articular cartilage, indicating a potential role of the disintegrin metalloproteinase in cartilage remodeling. (+info)Reconstruction and limb salvage after resection for malignant bone tumour of the proximal humerus. A sling procedure using a free vascularised fibular graft. (7/542)
We assessed the intermediate functional results of eight patients after wide resection of the proximal humerus for malignant bone tumour. We used a free vascularised fibular graft as a functional spacer and a sling procedure to preserve passive scapulohumeral movement. Scapulohumeral arthrodesis was not carried out. Five patients had osteosarcoma, two achondrosarcoma and one a malignant fibrous histiocytoma of the bone. The mean duration of follow-up was 70 months (median, 76) for the seven patients who were still alive at the time of the latest follow-up. One patient died from the disease 12 months after surgery. There were no local recurrences. The functional results were described and graded quantitatively according to the rating system of the Musculoskeletal Tumour Society. Our results were satisfactory with regard to pain, emotional acceptance and manual dexterity. Function and lifting ability were unsatisfactory in two patients. One patient had delayed union between host and graft, but this united after six months without further surgery. Radiographs of the shoulder showed absorption or collapse of the head of the fibula in four of the eight patients and a fracture in another. No functional problems related to absorption or fracture of the head of the fibula were noted. There was no infection or subluxation of the head. We conclude that this is a reasonably effective technique of limb salvage after resection of the proximal humerus. (+info)Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. (8/542)
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. Here we report that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC. Two tumors, one with a novel t(9;17)(q22;q11) variant translocation and one with an apparently normal karyotype, expressed TAF2N-TEC fusion transcripts. In both cases, the chimeric transcripts were shown to contain exon 6 of TAF2N fused to the entire coding region of TEC. This transcript is structurally and functionally very similar to the EWS-TEC fusions. The exchange of the EWS NH2-terminal part with the TAF2N NH2-terminal part in EMC further underscores the oncogenic potential of these protein domains as partners in fusion genes. (+info)
IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...
Xylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycan
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Dedifferentiated chondrosarcoma with pathological fracture - femur | Radiology Case | Radiopaedia.org
Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human...
Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation --...
IJMS | Free Full-Text | 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human...
AID 79237 - In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay - PubChem
Clear cell chondrosarcoma of the proximal femur with intrapelvic extension | AVESİS
Functional genomic analyses of the impact of global hypomethylation an by Christopher Allan Hamm
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. - PubMed -...
Bone: Dedifferentiated chondrosarcoma
Not all secondary bone tumours are secondaries. Concurrent metastatic breast carcinoma and chondrosarcoma of the femur | BMJ...
Low-Grade Cartilage Tumors: Background, Differentiation of Benign From Low-Grade Malignant Cartilage Tumors, Case Study 1
Polarity and Ploidy in Peripheral Chondrosarcoma Research Grant
Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm...
Chondrosarcoma
Low-grade chondrosarcoma: sternum | Radiology Case | Radiopaedia.org
Gentaur Molecular :US Biomax \ Osteosarcoma and chondrosarcoma tissue array, with stage, grade and TNM data, 80 cases 80 cores,...
Chondrosarcoma of the greater cornu of the hyoid: a case report and literature review.
Chondrosarcoma - Cow
A Study Of Chondrosarcoma, Bone And Cartilage Derived Cancer - Natural Height Growth
Dedifferentiated Peripheral Chondrosarcoma: A Review of Radiologic Characteristics
NewYork-Presbyterian Queens - Chondrosarcoma
NewYork-Presbyterian Queens - Chondrosarcoma
chondrosarcoma in dogs skull
Chondrosarcoma: Its treatment by radiation, hyperthermia and bleomycin<...
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma...
Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma
Supplementary Material for: MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β...
Robert Nakayama (Japan) | Clinical outcome of clear cell chondrosarcoma: A multicenter study from the Japanese musculoskeletal...
Lirias: Intramuscular mixed tumour with clonal chromosomal changes
Subglottic chondrosarcoma presenting only mild acute-onset dyspnea: a case report and review of the literature.
Plus it
Chondrosarcoma of the Thorax - Semantic Scholar
Clear-cell chondrosarcoma of the maxilla Report of a case
A chondrosarcoma in the anterior mediastinum mimicking a thymoma - Forskning - Region Hovedstaden
Búsqueda | Portal Regional de la BVS
Week 257: Case 2 | Johns Hopkins Surgical Pathology Unknown Conference
An extraskeletal chondrosarcoma of the maxilla. A case report<...
Mouth Cancer (Chondrosarcoma) in Dogs | petMD
Old Maid Cat Lady: Cancer in Cats: Chondrosarcoma
Reconstruction of Acetabular Wall Using Autologous Bone Graft Following Resection of Pelvic Chondrosarcoma: Surgical Technique...
Rare Cancer News & Clinical Trials » Trial - Sarcoma » Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma -...
Throat Cancer (Chondrosarcoma) in Dogs | PetMD
Chondrosarcoma | Johns Hopkins Medicine
Chondrosarcoma
Treatment Options for Chondrosarcoma | Stanford Health Care
GENERIC Chondrosarcoma
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report<...
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Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes<...
Do Orthopaedic Oncologists Agree on the Diagnosis and Treatment of Cartilage Tumors of the Appendicular Skeleton?
Radiosurgery for chordomas and chondrosarcomas of the skull base in: Journal of Neurosurgery Volume 107 Issue 4 (2007)
SurgeryXchange - If you are told you need a surgery, you need us
Hemipelvectomia no tratamento de condrossarcoma no acetábulo de cão
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case | Journal of Orthopaedic Case Reports
Chondrosarcoma - OzRadOnc
Plus it
The Radiology Assistant : Differential diagnosis of bone tumors
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor ...
Original Drugstore: Abilify withdrawal causes mania wide pills range!
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
Dedifferentiated chondrosarcomas of the larynx: a report of two cases and review of the literature
Alvin Deguzman
osteosarcoma | The Angeli Foundation
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Chondrosarcoma
CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma". The Lecturio Medical Concept Library. Retrieved 8 ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ... Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there ... Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. ...
Myxoid chondrosarcoma
... is a type of chondrosarcoma. It has been associated with a t(9;22) (q22;q12) EWS/CHN gene fusion. Goh YW ... November 2001). "Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno- ... "Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma". Am. J. ...
Extraskeletal myxoid chondrosarcoma
... (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ... "Myxoid Chondrosarcoma - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-02-04. "TAF15 TATA-box ... when they discussed the different species of extraskeletal chondrosarcoma, but EMC concept was firstly proposed in 1972 by ... Yang, Lei; Qin, Genggeng; Xu, Rong; Wang, Ruoning; Zhang, Ling (2018). "Extraskeletal Myxoid Chondrosarcoma: A Comparative ...
Synovial osteochondromatosis
"Chondrosarcoma". The Lecturio Medical Concept Library. Retrieved 8 July 2021. "Synovial Chondromatosis". Genetic And Rare ... Synovial chondrosarcoma Other: Osteochondritis dissecans Sequestrum from osteomyelitis Neuropathic (Charcot) joint Intra- ... Malignant transformation to synovial chondrosarcoma. This is a very rare complication occurring in chronic cases. Treatment ...
Chondroblast
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... S2CID 44703653.[permanent dead link] Aufderheide, A.C.; Rodríguez-Martín, C.; Langsjoen, O. (2011). "Chondrosarcoma". The ...
Orthopedic pathology
Depending on the type of chondrosarcoma, it ranges from a slow growth which is able to be removed, to a rapid growth and ... "Chondrosarcoma - Symptoms and causes". Mayo Clinic. Retrieved 2020-04-23. Reference, Genetics Home. "Chordoma". Genetics Home ... There are multiple other bone cancers that are more rare: Chondrosarcoma is identified mainly through the production of ...
BRICHOS family
... related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress ...
Alan L. Schiller
Coltrera MD, Googe PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML (1986). "Chondrosarcoma of the temporal bone. Diagnosis ...
Chordoma
"Chordoma and chondrosarcoma gene profile: implications for immunotherapy". Cancer Immunology, Immunotherapy. 58 (3): 339-49. ... Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. In most cases, complete surgical ...
Hereditary multiple exostoses
A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems ... Kivioja A, Ervasti H, Kinnunen J, Kaitila I, Wolf M, Böhling T (March 2000). "Chondrosarcoma in a family with multiple ...
William DeVries
" "Chondrosarcoma Masquerading as Cardiomyopathy" ; Charles R. Mulligan, Jr, Houman Tavaf-Motamen, Robert Stewart, and William ...
Cartilage
The benign tumors are called chondroma, the malignant ones chondrosarcoma. Tumors arising from other tissues may also produce a ...
IFFO1
However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...
Deaths in June 2008
Michael Turner, 37, American comic book artist and publisher, chondrosarcoma. Irina Baronova, 89, Russian ballerina, last of ...
Rahul Kukreti
Kukreti died from a rare form of cancer, undifferentiated chondrosarcoma. "USA Cricket: Former USA wicketkeeper Rahul Kukreti ...
Enchondroma
ISBN 978-0-323-52479-7. Wang XL, De Beuckeleer LH, De Schepper AM, Van Marck E (2001). "Low-grade chondrosarcoma vs enchondroma ... When differentiating an enchondroma from a chondrosarcoma, the radiographic image may be equivocal; however, periostitis is not ...
The Myriad
Drummer Randy Miller died from chondrosarcoma on November 5, 2010. The family set up a place for people to donate money to his ...
Black-necked spitting cobra
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-1607. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda ...
Tenascin C
... is implicated in a number of different cancers such as osteosarcomas, chondrosarcomas, bladder cancer, and ... "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306-14. doi:10.1159/ ...
List of dangerous snakes
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-7. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda; ...
LECT1
"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its ... "Expression of the chondromodulin-I gene in chondrosarcomas". Cancer Letters. 204 (1): 61-8. doi:10.1016/j.canlet.2003.09.015. ...
Vaccine-associated sarcoma
Fibrosarcoma is the most common VAS; other types include rhabdomyosarcoma, myxosarcoma, chondrosarcoma, malignant fibrous ...
Oral mucosa
Osteosarcoma, chondrosarcoma arise in bone and cartilage, lymphoma in haematological disorders (1). The most common ...
Benign tumor
Failure to stop growth can be indicative of transformation to malignant chondrosarcoma. Treatment is not indicated unless ...
Temporomandibular joint
These conditions include chondrosarcoma, osteosarcoma, giant cell tumor, and aneurysmal bone cyst. The temporomandibular joints ...
Polysomy
Abnormalities of chromosome 13 have been observed in canine osteoid chondrosarcoma and lymphosarcoma. Trisomy 13 in dogs with ...
Chandler Park
C. Park, A. Husain "PET scan negative metastatic chondrosarcoma," American College of Physicians. Research Presentation. ...
Bone metastasis
Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare; the most common bone tumor ...
VXN
These disease states include chondrosarcoma, glioma, kidney tumors, liver tumors, and germ cell tumors. VXN is only expressed ...
Aneurysmal bone cyst
Less frequently, it results from some malignant tumors, such as osteosarcoma, chondrosarcoma, and hemangioendothelioma.[ ...
Study of INBRX-109 in Conventional Chondrosarcoma | Rush System
Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients. INBRX-109 is a recombinant ... Have conventional chondrosarcoma that is unresectable (=inoperable) or metastatic.. *Have radiologic progression of disease per ... A Randomized, Blinded, Placebo-controlled, Phase 2 Study of INBRX-109 in Unresectable or Metastatic Conventional Chondrosarcoma ... Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients. INBRX-109 is a recombinant ...
Wednesday Warrior Nick - Cure Skeletal Chondrosarcoma
If you or a loved one has been impacted by skeletal chondrosarcoma cancer, we encourage you to share your story. Help us raise ... The tumor was then diagnosed as an extra skeletal chondrosarcoma. Dr. Morris set a surgery date one week after the biopsy ... Tags: cure sarcomacuresarcomaExtra Skeletal Chondrosarcomasarcomasarcoma cancersarcoma foundation of americaSarcoma Patient ...
Chondrosarcoma - Symptoms, Diagnosis & Treatment of Chondrosarcoma
Chondrosarcoma is a cartilaginous cancer (a cartilage-based bone cancer) that represents approximately 25% of all primary bone ... In many chondrosarcoma cases, the tissue can be extracted with a needle, but if the chondrosarcoma is located centrally in the ... Chondrosarcoma Symptoms and Features. The symptoms of chondrosarcoma vary depending on the location of the tumor. Furthermore, ... Chondrosarcoma Treatment. Chondrosarcomas are relatively rare. As a result, they are treated at hospitals with specialized ...
Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial - The Lancet...
Extraskeletal myxoid chondrosarcoma. Long-term experience with chemotherapy.. Am J Clin Oncol. 1995; 18: 161-163. View in ... Activity of sunitinib in extraskeletal myxoid chondrosarcoma.. Eur J Cancer. 2014; 50: 1657-1664. View in Article *Scopus (50) ... Extraskeletal myxoid chondrosarcoma.. in: Fletcher CD Bridge JA Hogendoorn PCW Mertens F WHO classification of tumours of soft ... Anthracycline-based chemotherapy in extraskeletal myxoid chondrosarcoma: a retrospective study.. Clin Sarcoma Res. 2013; 3: 16 ...
Cricoid Chondrosarcoma | Page 3 | Mayo Clinic Connect
High TIL, HLA, and Immune Checkpoint Expression in Conventional High-Grade and Dedifferentiated Chondrosarcoma and Poor...
Extraskeletal chondrosarcoma | Radiology Case | Radiopaedia.org
Patient Story: Chondrosarcoma
A case of slow growing, low grade chondrosarcoma in a young woman | Eurorad
Chondrosarcomas are mostly seen in the long bones (45%) such as the femur (20-35%), tibia (5%) and proximal humerus (10-20%), ... 3] Pring ME, Weber KL, Unni KK, Sim FH (2001). Chondrosarcoma of the pelvis. A review of sixty-four cases. J Bone Joint Surg Am ... Chondrosarcomas are malignant cartilaginous tumours accounting for about 25% of all primary malignant bone tumours. They can be ... Chondrosarcomas are either primary or secondary arising from a pre-existent cartilaginous lesion such as osteochondroma (aka ...
Novel Prognostication of Patients with Spinal and Pelvic Chondrosarcoma Using Deep Survival Neural Networks:An analysis of the...
Novel Prognostication of Patients with Spinal and Pelvic Chondrosarcoma Using Deep Survival Neural Networks:An analysis of the ... Learning Objectives: RED_SNN is a valid method of predicting survival for spinal chondrosarcoma ... including chondrosarcoma. Machine learning (ML) techniques to predict disease have shown higher diagnostic accuracy than ... network ML algorithms for the role and outcomes of surgical resection and radiation therapy in spinal and pelvic chondrosarcoma ...
Chondrosarcoma with Multimodal Therapy and SSA Disability
Chondrosarcoma with Multimodal Therapy Condition and Symptoms. Chondrosarcoma is a type of cancer that involves the cells that ... Treatment for chondrosarcoma may vary depending on where the cancer originated and what stage the cancer is in. Because this ... Chondrosarcoma with Multimodal Therapy and Your Social Security Disability Case. When applying for disability benefits based on ... When an individual is suffering from chondrosarcoma he or she must not only face the symptoms of the cancer itself, but must ...
Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent...
Dive into the research topics of Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a ... Activated PI3-K and ERK1/2 signaling pathways phosphorylate c-Jun, which in turn transactivates MMP-1 in human chondrosarcoma ... Activated PI3-K and ERK1/2 signaling pathways phosphorylate c-Jun, which in turn transactivates MMP-1 in human chondrosarcoma ... Activated PI3-K and ERK1/2 signaling pathways phosphorylate c-Jun, which in turn transactivates MMP-1 in human chondrosarcoma ...
Mesenchymal Chondrosarcoma Map | Find people with Mesenchymal Chondrosarcoma in the map
Chondrosarcoma of bone with dedifferentiation: A study of eighteen cases<...
Chondrosarcoma of bone with dedifferentiation: A study of eighteen cases. Human pathology. 1982 Jan;13(1):36-40. doi: 10.1016/ ... Chondrosarcoma of bone with dedifferentiation : A study of eighteen cases. / McCarthy, Edward F.; Dorfman, Howard D. ... McCarthy, Edward F. ; Dorfman, Howard D. / Chondrosarcoma of bone with dedifferentiation : A study of eighteen cases. In: Human ... McCarthy, E. F., & Dorfman, H. D. (1982). Chondrosarcoma of bone with dedifferentiation: A study of eighteen cases. Human ...
Bone Sarcoma Guidelines: Diagnosis and Classification, Grading and Staging Systems, Treatment
Chondrosarcoma. NCCN recommendations for treatment of chondrosarcoma are as follows [1] :. * Enrollment in a clinical trial ... and low-grade peripheral chondrosarcomas be surgically excised. Higher-grade chondrosarcomas and all chondrosarcomas of the ... Dedifferentiated chondrosarcoma is often treated as a high-grade bone sarcoma, with systemic and local therapies that need to ... Skull base chondrosarcomas can be treated with high-dose radiation therapy, including proton or carbon ion beam radiation ...
IMSEAR at SEARO: Extra-skeletal chondrosarcoma.
Chondrosarcoma | Osmosis
Mesenchymal Chondrosarcoma - JTV
bone cancer-chondrosarcoma | Marielle Does
Posts about bone cancer-chondrosarcoma written by marialeila ... Tag Archives: bone cancer-chondrosarcoma. Waltzing Through The ... Posted in chondrosarcoma, XYZ , Tagged bone cancer-chondrosarcoma, chondrosarcoma, chondrosarcoma grade 1, chondrosarcoma story ... Posted in chondrosarcoma, XYZ , Tagged bone cancer-chondrosarcoma, chondrosarcoma, chondrosarcoma grade 1, chondrosarcoma story ...
Chondrosarcoma in Cats - Applecross Veterinary Hospital
Chondrosarcoma in Cats Home » Pet Health » Pet Health Library » Library. What is chondrosarcoma?. Chondrosarcomas arise from ... How does chondrosarcoma typically progress?. Although the mass may grow rapidly, less than 20% of chondrosarcoma cases in cats ... Cats with chondrosarcoma of the long bones often develop lameness as the first clinical sign of chondrosarcoma. This lameness ... What are the treatments for chondrosarcoma?. Surgical excision is the treatment of choice for chondrosarcoma, if feasible. This ...
Dedifferentiated chondrosarcoma: Radiological features, prognostic factors and survival statistics in 23 patients | Read by QxMD
Chondrosarcoma of bone: an assessment of outcome. F Y Lee, H J Mankin, G Fondren, M C Gebhardt, D S Springfield, A E Rosenberg ... Dedifferentiated chondrosarcoma. A study of 13 clinical cases and review of the literature]. P Anract, B Tomeno, M Forest Revue ... Pelvic chondrosarcomas: surgical treatment options. X Deloin, V Dumaine, D Biau, M Karoubi, A Babinet, B Tomeno, P Anract ... Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. Ian D Dickey, Peter S Rose, Bruno Fuchs, ...
Dedifferentiated Chondrosarcoma - Which Foods and Supplements? | addon.life
Dedifferentiated Chondrosarcoma is a cancer for which foods and supplements recommended and those to avoid must be personalized ... Tags: Dedifferentiated Chondrosarcoma , Dedifferentiated Chondrosarcoma chemotherapy , Dedifferentiated Chondrosarcoma genetic ... Dedifferentiated Chondrosarcoma treatment , diet Dedifferentiated Chondrosarcoma , foods for Dedifferentiated Chondrosarcoma , ... 2. Significance of Nutrition for Dedifferentiated Chondrosarcoma 3. Foods for Dedifferentiated Chondrosarcoma undergoing ...
Chondrosarcoma: Background and current status - Carson's Cancer Journey
18 thoughts on "Chondrosarcoma: Background and current status" * Tammy Crutsinger says: So sorry to hear this ! You and your ... Both masses came back positive as Chondrosarcoma so 2 weeks later I had surgery on my left lung. Again, not a fun recovery but ... Chondrosarcoma: Background and current status. December 20, 2015. December 20, 2015. cgb21 ... We were hoping that I would be eligible for a trial that has had some success in Chondrosarcoma but unfortunately, my cancer ...
Recent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268 - 1st Edition
Non-Conventional Treatments for Conventional Chondrosarcoma - Making the Rounds
Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied ... Non-Conventional Treatments for Conventional Chondrosarcoma Authors: Varun Monga, Hariharasudan Mani, Angela Hirbe, Mohammed ... Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied ... The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver ...
Tissue microarrays analysis in chondrosarcomas: light microscopy, immunohistochemistry and xenograft study | Diagnostic...
Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone and can be primary or secondary, the latter ... Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone and can be primary or secondary, the latter ... Therefore, the aims of this study are firstly the analysis of heterogeneity in Chondrosarcomas by means of TMA technology using ... Bovee JV, Cleton-Jansen AM, Taminiau AH, Hogendoorn PC: Emerging pathways in the development of chondrosarcoma of bone and ...
Clear Cell Chondrosarcoma : Bone Tumor Cancer : Tumors of the bone
Comprehensive information about Clear Cell Chondrosarcoma including signs and symptoms, diagnosis, radiology, pathology, ... chondrosarcoma, clear cell chondrosarcoma, diagnosis clear cell chondrosarcoma, radiology clear cell chondrosarcoma, pathology ... clear cell chondrosarcoma, surgery clear cell chondrosarcoma, prognosis clear cell chondrosarcoma, epiphyseal tumor, cartilage ... Thank-you so very much for being my surgeon for that chondrosarcoma, for saving my life! And I have learned over the months ( ...
TumorChordomaOsteosarcomaTumorsDiagnosisHuman chondrosarcoma cellsPathologyCase of chondrosarcomaPrognosis of chondrosarcomaCancersMesenchymalChemotherapyGrade chondrosarcomaExtraskeletal chondrosarcomaAbstractChordomasPelvicOsteochondromasConventionalCartilaginousTypicallyConnective tissueLong bonesRecurrenceClinicalCartilage cellsSurgicalPelvisSymptomsTreatmentBiopsyTissueEnchondromaSkullCommon malignantMalignant transformationDedifferentiationTreatmentsOccursRareTherapeuticCancerHistologicalPatientsBonesGeneticImaging
Tumor17
- The tumor was then diagnosed as an extra skeletal chondrosarcoma. (curesarcoma.org)
- The symptoms of chondrosarcoma vary depending on the location of the tumor. (knowcancer.com)
- Chondrosarcoma is a rare tumor in cats, but it can occur. (applecrossvet.ca)
- The clinical signs of chondrosarcoma may vary significantly, depending upon where the tumor arises. (applecrossvet.ca)
- Clinical signs associated with chondrosarcoma at these sites will vary depending on the location of the tumor. (applecrossvet.ca)
- Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. (qxmd.com)
- These tumor genetic details of Dedifferentiated Chondrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Dedifferentiated Chondrosarcoma. (addon.life)
- The symptoms of Chondrosarcoma may vary widely according to the location of the affected cells and tumor. (csfshayna.org)
- We present a case of dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation harboring a prominent rhabdoid tumor component. (bvsalud.org)
- Typical considerations for this end-of-bone neoplastic lesion are giant cell tumor, clear cell chondrosarcoma, and chondroblastoma. (elsevier.com)
- To develop a machine learning model based on 3D MRI radiomics to differentiate atypical cartilaginous tumor (ACT) from grade II chondrosarcoma (CS2) of long bones. (convegnonazionaleaiic.it)
- Chondrosarcoma is a malignant tumor that is characterized by the formation of cartilage by tumor. (gopetsamerica.com)
- Although dedifferentiation in a chondrosarcoma was strongly considered, the pattern was considered unusual and the possibility of a collision tumor (enchondroma with desmoplastic fibroma) was also entertained, with recommended treatment to achieve control of a locally aggressive neoplasm. (biomedscis.com)
- Chondrosarcoma is a malignant tumor occupying the 2nd position in terms of frequency, all ages combined, after osteosarcoma [1]. (peertechzpublications.com)
- Chondrosarcoma, a malignant tumor of cartilaginous origin, is the most common of the adult primary bone cancers. (drrathresearch.org)
- Chondrosarcoma (CS), a malignancy of cartilaginous origin, is an aggressive cancer with poor prognosis, due to both its aggressive metastatic spread and the lack of efficacy in current treatment modalities to prevent or counteract tumor progression. (drrathresearch.org)
- In the latest version of the guidelines released in November 2020, surgery is the main treatment for chondrosarcoma, chordoma, and giant cell tumor of bone, which can be combined with radiotherapy or targeted therapy. (bvsalud.org)
Chordoma2
- With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
- Surgical en bloc resection with negative margins is the only curative treatment for chordoma. (medscape.com)
Osteosarcoma3
- Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone exceeded only by myeloma and osteosarcoma. (biomedcentral.com)
- He has managed many complex cases in both adults and children, including osteosarcoma, chondrosarcoma, and Ewing's sarcoma. (doctify.com)
- Fourteen histopathologic types were found of which osteosarcoma (28%), chondrosarcoma (17%), rhabdomyosarcoma (12%) and fibrosarcoma (12%) were predominant. (bvsalud.org)
Tumors7
- The Surveillance, Epidemiology, and End Results (SEER) database has been queried to include all malignant osseous spinal tumors, including chondrosarcoma. (cns.org)
- Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. (internalmedicineiowa.org)
- Dedifferentiated chondrosarcomas (DDCS) are rare lesions, defined as tumors having a low-grade chondrosarcomatous component with an abrupt transition to a high-grade sarcoma . (bvsalud.org)
- Mesenchymal chondrosarcomas (MCs) are infrequent, slowâ growing malignant tumors of head and neck region affecting both bone and soft tissues. (amhsr.org)
- Chondrosarcomas are tumors composed of cancerous cartilage cells. (msdmanuals.com)
- Many chondrosarcomas are slow-growing or low-grade tumors, meaning that they are less likely to spread (metastasize) than some other tumors. (msdmanuals.com)
- However, some chondrosarcomas are fast-growing or high-grade tumors, which tend to metastasize. (msdmanuals.com)
Diagnosis4
- We sought to develop and validate deep survival neural network ML algorithms to predict survival following diagnosis of chondrosarcoma, using a SEER database. (cns.org)
- When you file a Social Security Disability claim based on a diagnosis of chondrosarcoma and you are undergoing multimodal therapy to treat the condition, you will need to provide very detailed answers to the SSA regarding the affect the condition has had on your daily lifestyle. (disabilitybenefitscenter.org)
- Final diagnosis was based on histological examination, which confirmed the hypothesis of low-grade parafalcine chondrosarcoma. (neoplasiaresearch.com)
- According to the American Cancer Society, Chondrosarcomas develops most often in adults, with an average age at diagnosis of 51 . (jeffersoncityheadlines.com)
Human chondrosarcoma cells3
- Activated PI3-K and ERK1/2 signaling pathways phosphorylate c-Jun, which in turn transactivates MMP-1 in human chondrosarcoma cells. (elsevier.com)
- Collectively, fluid shear stress upregulates matrix MMP-1 expression, which is responsible for the enhanced invasion of human chondrosarcoma cells. (elsevier.com)
- Dive into the research topics of 'Cell density-dependent proliferative effects of transforming growth factor (TGF)-β1, β2, and β3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-β receptor type I'. Together they form a unique fingerprint. (elsevier.com)
Pathology2
- McCarthy, EF & Dorfman, HD 1982, ' Chondrosarcoma of bone with dedifferentiation: A study of eighteen cases ', Human pathology , vol. 13, no. 1, pp. 36-40. (elsevier.com)
- Twenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015. (qxmd.com)
Case of chondrosarcoma4
- Because the combination of symptoms can leave a person completely disabled, a case of chondrosarcoma with multimodal therapy may qualify an individual for claim processing under the SSA's Compassionate Allowances guidelines. (disabilitybenefitscenter.org)
- In the case of chondrosarcoma with multimodal therapy, this will include lab results, imaging results, treatment histories and written statements from your treating physician. (disabilitybenefitscenter.org)
- When applying for disability benefits based on a case of chondrosarcoma with multimodal therapy you may want to enlist the assistance of an attorney who specializes in disability cases. (disabilitybenefitscenter.org)
- In the case of chondrosarcoma, no specific risk factors or cause have been identified. (applecrossvet.ca)
Prognosis of chondrosarcoma1
- Based on the poor prognosis of chondrosarcoma, we investigated effects of a phytonutrient mixture (PB) containing quercetin, CruciferexTM, curcumin, resveratrol and green tea extract on several parameters associated with the development of this type of cancer. (drrathresearch.org)
Cancers4
- Nearly 30 percent of cancers that affect the skeletal system are classified as chondrosarcomas. (disabilitybenefitscenter.org)
- For cancers like Dedifferentiated Chondrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Dedifferentiated Chondrosarcoma because of IDH1 and POLE gene mutations, a very important question is "What foods should I avoid and what foods are recommended specifically for me? (addon.life)
- There is no one answer to this question for cancers such as Dedifferentiated Chondrosarcoma which can be found through internet searches. (addon.life)
- Forty percent of primary bone cancers are chondrosarcoma. (drrathresearch.org)
Mesenchymal3
- Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. (docksci.com)
- Coex stence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hem hyperplas a: A Case Report Nihat Demirhan Demirkiran¹, Olcay Akdeniz¹, Onur Hapa¹, Hasan Havıtçıoğlu¹ What to Learn from this Article? (docksci.com)
- Parker JR, Zarabi MC, Parker JC Jr. Intracerebral mesenchymal chondrosarcoma. (neoplasiaresearch.com)
Chemotherapy4
- Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. (qxmd.com)
- Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. (internalmedicineiowa.org)
- The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. (internalmedicineiowa.org)
- However as chondrosarcoma typically does not respond to radiation and chemotherapy, surgery is the main treatment option. (drrathresearch.org)
Grade chondrosarcoma2
- This corresponded to combined histologic patterns of high grade sarcoma, usually with features of a malignant fibrous histiocytoma, and a low grade chondrosarcoma. (elsevier.com)
- Dedifferentiation of a low-grade chondrosarcoma is thought to occur when a high-grade sarcoma develops within the locally aggressive lesion [1]. (biomedscis.com)
Extraskeletal chondrosarcoma3
- Skalski M, Extraskeletal chondrosarcoma. (radiopaedia.org)
- Case of pathologically proven extraskeletal chondrosarcoma . (radiopaedia.org)
- A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. (cancer.gov)
Abstract1
- abstract = "Matrix metalloproteinase-1 (MMP-1) is a potential biomarker for chondrosarcoma that is overexpressed at the invading edges of articular cartilage, and its expression correlates with poor survival rates. (elsevier.com)
Chordomas6
- This study presents an analysis (efficacy and toxicity) of outcomes in patients with skull-base chordomas or chondrosarcomas treated with a fixed horizontal pencil proton beam. (biomedcentral.com)
- Chordomas (CAs) and chondrosarcomas (CSAs) are rare tumours that are usually located near the base of the skull and very close to the brain's most critical structures. (biomedcentral.com)
- Treatment with a fixed proton beam shows promising disease control and an acceptable toxicity rate, even the difficult-to-treat subpopulation of patients with skull-base chordomas or chondrosarcomas requiring dose escalation. (biomedcentral.com)
- Chordomas and chondrosarcomas are rare among malignancies and mainly affect the skull base, sacrum bones, and vertebral column (less). (biomedcentral.com)
- Chondroid describes chordomas that are difficult to distinguish from chondrosarcoma on histology. (medscape.com)
- Typically, chordomas express the brachyury gene, whereas chondrosarcomas do not express this gene. (medscape.com)
Pelvic2
Osteochondromas3
- Imaging is important to differentiate benign osteochondromas from chondrosarcomas and to identify hereditary multiple exostoses syndrome, who is more likely to become malignant. (eurorad.org)
- Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. (qxmd.com)
- 2019), most Chondrosarcomas are sporadic, but they may develop from the malignant transformation of osteochondromas and enchondromas. (jeffersoncityheadlines.com)
Conventional5
- Have conventional chondrosarcoma that is unresectable (=inoperable) or metastatic. (rush.edu)
- In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma. (internalmedicineiowa.org)
- A 78-year-old female patient with a lesion in the distal tibia is shown to have conventional intramedullary chondrosarcoma. (elsevier.com)
- Salient clinical and radiographic features and behavior of this lesion broaden the typical view of conventional intramedullary chondrosarcoma. (elsevier.com)
- Kothary N, Law M, Cha S, Zagzag D. Conventional and Perfusion MR Imaging of Parafalcine Chondrosarcoma. (neoplasiaresearch.com)
Cartilaginous6
- Chondrosarcoma is a cartilaginous cancer (a cartilage-based bone cancer) that represents approximately 25% of all primary bone cancer cases. (knowcancer.com)
- Chondrosarcomas are malignant cartilaginous tumours accounting for about 25% of all primary malignant bone tumours. (eurorad.org)
- Chondrosarcoma begins in cartilaginous tissue. (cancer.gov)
- Dedifferentiated chondrosarcoma typically has 2 microscopic components, whereby the low-grade cartilaginous lesion is seen with a high grade sarcomatous component with an abrupt transition between the 2 zones [1]. (biomedscis.com)
- The procedure was performed under image intensifier control and the histological picture of the specimen showed features of a dedifferentiated lowgrade chondrosarcoma with abrupt demarcation between a distinct cartilaginous component and a spindle cell component. (biomedscis.com)
- Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS . (bvsalud.org)
Typically3
- Initial screening tests for chondrosarcoma typically involves screening laboratory tests (bloodwork and urinalysis), as well as radiographs (X-rays) of the affected bone or joint. (applecrossvet.ca)
- How does chondrosarcoma typically progress? (applecrossvet.ca)
- Chondrosarcoma is a cartilage forming tumour, typically found in flat bones such as the ilium. (biomedscis.com)
Connective tissue1
- Chondrosarcomas arise from cartilage, which is a connective tissue found where bones meet with joints. (applecrossvet.ca)
Long bones2
- Approximately 44% of cases of chondrosarcoma in cats are found in the long bones, which are the bones that are found in the legs. (applecrossvet.ca)
- Cats with chondrosarcoma of the long bones often develop lameness as the first clinical sign of chondrosarcoma. (applecrossvet.ca)
Recurrence1
- Cranial Chondrosarcoma and Recurrence. (neoplasiaresearch.com)
Clinical4
- What are the clinical signs of chondrosarcoma? (applecrossvet.ca)
- Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute. (qxmd.com)
- Following key highlights are derived from clinical data for Dedifferentiated Chondrosarcoma from cBioPortal. (addon.life)
- Currently, Inhibrx has its Chondrosarcoma drug candidates in the most advanced stage of clinical development. (jeffersoncityheadlines.com)
Cartilage cells2
- Chondrosarcoma is a rare form of bone cancer that develops in cartilage cells, particularly that of the femur, arm, pelvis, knee, and ribs. (csfshayna.org)
- Chondrosarcoma is a bone sarcoma that develops in the cartilage cells. (jeffersoncityheadlines.com)
Surgical3
- Surgical resection is considered to be the standard method, and only curative method, for treating chondrosarcoma. (knowcancer.com)
- Surgical excision is the treatment of choice for chondrosarcoma, if feasible. (applecrossvet.ca)
- Overall 5-year survival is approximately 50%, and treatment consists of en bloc surgical resection followed by high-dose conformal radiation therapy (RT) such as proton beam radiation. (medscape.com)
Pelvis2
- Chondrosarcoma most often forms in the pelvis , upper leg, and shoulder and usually grows slowly, although sometimes it can grow quickly and spread to other parts of the body. (cancer.gov)
- Neoplasia maligna derivada de células cartilaginosas, más frecuente en los huesos de la pelvis o cerca de los extremos de los huesos largos, en personas maduras y ancianas. (bvsalud.org)
Symptoms1
- When an individual is suffering from chondrosarcoma he or she must not only face the symptoms of the cancer itself, but must also deal with the symptoms associated with the treatments that are being administered. (disabilitybenefitscenter.org)
Treatment5
- Treatment for chondrosarcoma may vary depending on where the cancer originated and what stage the cancer is in. (disabilitybenefitscenter.org)
- Treatment strategies for Chondrosarcoma rely on the removal of the tumorous mass and reducing the likelihood it will return. (csfshayna.org)
- Even though surgery remains the mainstay of treatment for cerebral chondrosarcomas, adjuvant radiotherapy such as stereotactic, proton beam or carbon ion-beam therapy might be necessary in aggressive or incomplete removed cases. (neoplasiaresearch.com)
- The Chondrosarcoma Foundation, Inc. will host their fourth International Forum / Virtual Dialogue featuring the following prominent experts to address new innovations, findings and technologies to improve the treatment of Chondrosarcoma. (csfshayna.org)
- The Chondrosarcoma market report covers emerging drugs, current treatment practices, market share of the individual therapies, and current & forecasted market size from 2019 to 2032. (jeffersoncityheadlines.com)
Biopsy2
- In many chondrosarcoma cases, the tissue can be extracted with a needle, but if the chondrosarcoma is located centrally in the body, then the biopsy necessitates surgery. (knowcancer.com)
- Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases. (qxmd.com)
Tissue1
- New cortical irregularity or continued growth after skeletal maturity, as well as frankly aggressive features (e.g. bony destruction, large soft tissue component, metastases) are all worrying for malignant transformation to chondrosarcoma. (eurorad.org)
Enchondroma1
- While the exact cause of chondrosarcoma is unknown, it is thought that patients who have a history of osteochondroma or enchondroma are at an increased risk of developing this type of cancer. (disabilitybenefitscenter.org)
Skull1
- In cases where the chondrosarcoma affects the skull, spine, or chest cavity, a neurosurgeon or a thoracic surgeon usually performs the operation. (knowcancer.com)
Common malignant1
- Chondrosarcomas are known to be the third most common malignant tumour occurring in bone and constitutes approximately 20% of primary bone sarcomas [3]. (biomedscis.com)
Malignant transformation1
- Chondrosarcoma (Chs) is the third most frequent primary malignant tumour of bone and can be primary or secondary, the latter results mainly from the malignant transformation of a benign pre-existing tumour. (biomedcentral.com)
Dedifferentiation2
- Eighteen patients with chondrosarcomas showing dedifferentiation were reviewed. (elsevier.com)
- This pattern of dedifferentiation occurs in about 10% of chondrosarcomas [2,3]. (biomedscis.com)
Treatments2
- What are the treatments for chondrosarcoma? (applecrossvet.ca)
- The overall objective of personalized nutrition for Dedifferentiated Chondrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. (addon.life)
Occurs1
- Chondrosarcoma occurs mainly in older adults (over age 40). (cancer.gov)
Rare3
- Chondrosarcomas are relatively rare. (knowcancer.com)
- He stated, "You have been diagnosed with a rare bone cancer called Chondrosarcoma. (cgbblog.net)
- Chondrosarcoma is a rare malignant tumour arising from the cartilage with a high variability in the clinicalcourse and overall prognosis. (neoplasiaresearch.com)
Therapeutic1
- Significant inhibition of important hallmarks of cancer progression by PB mixture suggests that this nutrient composition should be explored further as a therapeutic agent in chondrosarcoma. (drrathresearch.org)
Cancer4
- Chondrosarcoma is a type of cancer that involves the cells that are created from the transformed cells that produce cartilage. (disabilitybenefitscenter.org)
- We were hoping that I would be eligible for a trial that has had some success in Chondrosarcoma but unfortunately, my cancer does not have the eligible mutation. (cgbblog.net)
- According to the US Surveillance, Epidemiology and End Results Program, Chondrosarcomas contribute to 30% of different types of bone cancer. (jeffersoncityheadlines.com)
- Chondrosarcomas are characterized by high levels of proteases, which are involved in the degradation of ECM and the basement membrane, thus allowing cancer cells to invade and metastasize to distal organs. (drrathresearch.org)
Histological1
- Histological features were consistent with a dedifferentiated chondrosarcoma. (biomedscis.com)
Patients1
- In addition, patients who suffer from Ollier disease and Maffucci syndrome may also be at an increased risk of developing chondrosarcoma. (disabilitybenefitscenter.org)
Bones1
- Nearly 26% of chondrosarcoma cases in cats involve the flat bones. (applecrossvet.ca)
Genetic2
- Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. (internalmedicineiowa.org)
- There may be a genetic or chromosomal component that makes certain people more likely to develop Chondrosarcoma. (csfshayna.org)
Imaging1
- Following a complete medical history review and several standard physical exam procedures, a chondrosarcoma may be diagnosed using a variety of imaging techniques. (knowcancer.com)