A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
Tumors or cancer located in bone tissue or specific BONES.
Benign growths of cartilage in the metaphyses of several bones.
A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Glycoproteins which have a very high polysaccharide content.
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Cancer or tumors of the MAXILLA or upper jaw.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A voluntary organization concerned with the prevention and treatment of cancer through education and research.
Fibrous, bony, cartilaginous and osteocartilaginous fragments in a synovial joint. Major causes are osteochondritis dissecans, synovial chondromatosis, osteophytes, fractured articular surfaces and damaged menisci.
Multiple formation of chondromas. (Dorland, 27th ed)
Individual's rights to obtain and use information collected or generated by others.
The compartment containing the anterior extremities and half the inferior surface of the temporal lobes (TEMPORAL LOBE) of the cerebral hemispheres. Lying posterior and inferior to the anterior cranial fossa (CRANIAL FOSSA, ANTERIOR), it is formed by part of the TEMPORAL BONE and SPHENOID BONE. It is separated from the posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) by crests formed by the superior borders of the petrous parts of the temporal bones.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.

Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD). (1/542)

Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short times after injection of photosensitizer. Groups of rats with chondrosarcoma were given 2 mg kg(-1) of BPD intravenously 5 min to 180 min before light treatment of 150 J cm(-2) 690 nm. Vascular response was monitored using intravital microscopy and tumour cure was monitored by following regrowth over 42 days. For treatment at 5 or 30 min after BPD injection, blood flow stasis was limited to tumour microvasculature with lesser response in the surrounding normal microvasculature, indicating selective targeting for damage. No acute changes were observed in vessels when light was given 180 min after BPD injection. Tumour regression after light treatment occurred in all animals given PDT with BPD. Long-term tumour regression was greater in animals treated 5 min after BPD injection and least in animals given treatment 180 min after drug injection. The correlation between the timing for vascular damage and cure implies that blood flow stasis plays a significant role in PDT-induced tumour destruction.  (+info)

The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. (2/542)

The EWS/TEC gene fusion generated by the t(9;22) chromosomal translocation found in extraskeletal myxoid chondrosarcomas encodes a fusion protein containing the amino-terminal domain of the EWS protein fused to the whole coding sequence of the orphan nuclear receptor TEC. We have compared the DNA-binding and transcriptional activation properties of various TEC isoforms and the corresponding EWS/TEC fusion proteins. Band-shift experiments show that the full-length TEC receptor can efficiently bind the NGFI-B Response Element (NBRE), whereas an isoform lacking the entire carboxyl-terminal domain of the receptor binds much less efficiently the NBRE. Addition of the amino-terminal domain of EWS to either isoforms does not alter significantly their DNA-binding properties to the NBRE. Co-transfection experiments of COS cells and human chondrocytes indicate that whereas TEC moderately activates transcription from a NBRE-containing promoter, the corresponding EWS/TEC fusion protein is a highly potent transcriptional activator of the same promoter, being approximately 270-fold more active than the native receptor. EWS/TEC may thus exert its oncogenic potential in chrondrosarcomas by activating the transcription of target genes involved in cell proliferation.  (+info)

Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (3/542)

We report here the isolation and sulphation isomer analyses of trisaccharides GalNAcS(beta1,4)GlcA(beta1,3)GalNAcS (in which S indicates sulphate) derived from the non-reducing termini of aggrecan chondroitin sulphate. Rat chondrosarcoma and human aggrecans were digested for 1 h at 37 degrees C with 30 micro-units of endo-chondroitinase ABC per microgram of chondroitin sulphate, and trisaccharides were isolated from the digests by ToyoPearl HW40S gel-filtration chromatography. Four trisaccharide species were identified; their sulphation isomer compositions, as determined by digestion with chondroitinase ACII and fluorescence-based ion-exchange HPLC, were GalNAc4Sbeta1,4GlcAbeta1,3GalNAc4S, GalNAc4Sbeta1,4GlcAbeta1,3GalNAc6S, GalNAc4,6Sbeta1,4GlcAbeta1, 3GalNAc4S and GalNAc4,6Sbeta1,4GlcAbeta1,3GalNAc6S. The abundances of such sequences in chondroitin sulphate on aggrecan from normal (foetal to 72 years of age) and from osteoarthritic human knee cartilages were also established. The results showed that non-reducing terminal GalNAc4S or GalNAc4,6S can be linked to either a 4-sulphated or a 6-sulphated disaccharide, suggesting that the sulphation of the last disaccharide might not have a direct effect on the specificity of chondroitin sulphate terminal GalNAc sulphotransferases. Furthermore, for each aggrecan preparation examined, the 4S-to-6S ratio of all chain interior disaccharides was equivalent to that in the last repeating disaccharides at the non-reducing terminus, suggesting that neither chondroitin 4-sulphotransferase nor chondroitin 6-sulphotransferase shows preferential activity near the chain terminus.  (+info)

EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. (4/542)

Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether inactivation of both alleles of an EXT gene, according to the tumor-suppressor model, is required for osteochondroma development, or whether a single EXT germline mutation acts in a dominant negative way. We therefore studied loss of heterozygosity and DNA ploidy in eight sporadic and six hereditary osteochondromas. EXT1- and EXT2-mutation analysis was performed in a total of 34 sporadic and hereditary osteochondromas and secondary peripheral chondrosarcomas. We demonstrated osteochondroma to be a true neoplasm, since aneuploidy was found in 4 of 10 osteochondromas. Furthermore, LOH was almost exclusively found at the EXT1 locus in 5 of 14 osteochondromas. Four novel constitutional cDNA alterations were detected in exon 1 of EXT1. Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild-type allele in three osteochondromas, indicating that, in cartilaginous cells of the growth plate, inactivation of both copies of the EXT1 gene is required for osteochondroma formation in hereditary cases. In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene.  (+info)

Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. (5/542)

The sulfurylase domain of the mouse bifunctional enzyme ATP sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains HXXH and PP-loop motifs. To elucidate the functional importance of these motifs and of conserved arginines and histidines, chemical modification and site-directed mutagenesis studies were performed. Chemical modification of arginines and histidines with phenylglyoxal and diethyl pyrocarbonate, respectively, renders the enzyme inactive in sulfurylase, kinase, and overall assays. Data base searches and sequence comparison of bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number of highly conserved arginines and histidines within the sulfurylase domain. Of these conserved residues, His-425, His-428, and Arg-421 are present within or near the HXXH motif whereas His-506, Arg-510, and Arg-522 residues are present in and around the PP-loop. The functional role of these conserved residues was further studied by site-directed mutagenesis. In the HXXH motif, none of the alanine mutants (H425A, H428A, and R421A) had sulfurylase or overall activity, whereas they all exhibited normal kinase activity. A slight improvement in reverse sulfurylase activity (<10% residual activity) and complete restoration of forward sulfurylase was observed with R421K. Mutants designed to probe the PP-loop requirements included H506A, R510A, R522A, R522K, and D523A. Of these, R510A exhibited normal sulfurylase and kinase activity, R522A and R522K showed no sulfurylase activity, and H506A had normal sulfurylase activity but produced an effect on kinase activity (<10% residual activity). The single aspartate, D523A, which is part of the highly conserved GRD sequence of the PP-loop, affected both sulfurylase and kinase activity. This mutational analysis indicates that the HXXH motif plays a role only in the sulfurylase activity, whereas the PP-loop is involved in both sulfurylase and kinase activities. Residues specific for sulfurylase activity have also been distinguished from those involved in kinase activity.  (+info)

Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. (6/542)

OBJECTIVE: The aim of the study was to investigate the messenger RNA (mRNA) expression of the disintegrin metalloproteinase MDC15 (metargidin, or ADAM-15) in normal and osteoarthritic (OA) articular cartilage. METHODS: In situ hybridization experiments and reverse transcription-polymerase chain reaction (RT-PCR) were performed on tissue samples of adult normal and OA articular cartilage. RESULTS: MDC15 mRNA could be detected in normal articular cartilage by RT-PCR using tissue-extracted total RNA as a template. However, the mRNA level remained below the sensitivity of in situ hybridization. In contrast, in situ hybridizations of OA cartilage revealed an intense staining with the MDC15-specific riboprobes. The extension of the analysis to chondrosarcomas showed a strong up-regulation of MDC15 mRNA in these malignant transformed cells. CONCLUSION: Our results demonstrate a markedly strong up-regulation of MDC15 in adult OA and neoplastic cartilage compared with adult normal articular cartilage, indicating a potential role of the disintegrin metalloproteinase in cartilage remodeling.  (+info)

Reconstruction and limb salvage after resection for malignant bone tumour of the proximal humerus. A sling procedure using a free vascularised fibular graft. (7/542)

We assessed the intermediate functional results of eight patients after wide resection of the proximal humerus for malignant bone tumour. We used a free vascularised fibular graft as a functional spacer and a sling procedure to preserve passive scapulohumeral movement. Scapulohumeral arthrodesis was not carried out. Five patients had osteosarcoma, two achondrosarcoma and one a malignant fibrous histiocytoma of the bone. The mean duration of follow-up was 70 months (median, 76) for the seven patients who were still alive at the time of the latest follow-up. One patient died from the disease 12 months after surgery. There were no local recurrences. The functional results were described and graded quantitatively according to the rating system of the Musculoskeletal Tumour Society. Our results were satisfactory with regard to pain, emotional acceptance and manual dexterity. Function and lifting ability were unsatisfactory in two patients. One patient had delayed union between host and graft, but this united after six months without further surgery. Radiographs of the shoulder showed absorption or collapse of the head of the fibula in four of the eight patients and a fracture in another. No functional problems related to absorption or fracture of the head of the fibula were noted. There was no infection or subluxation of the head. We conclude that this is a reasonably effective technique of limb salvage after resection of the proximal humerus.  (+info)

Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. (8/542)

Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. Here we report that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC. Two tumors, one with a novel t(9;17)(q22;q11) variant translocation and one with an apparently normal karyotype, expressed TAF2N-TEC fusion transcripts. In both cases, the chimeric transcripts were shown to contain exon 6 of TAF2N fused to the entire coding region of TEC. This transcript is structurally and functionally very similar to the EWS-TEC fusions. The exchange of the EWS NH2-terminal part with the TAF2N NH2-terminal part in EMC further underscores the oncogenic potential of these protein domains as partners in fusion genes.  (+info)

Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of αvβ3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated that IL-8 enhances the migration of chondrosarcoma cells by increasing αvβ3 integrin ...
article{52f6a2c0-7074-42f4-ae84-0c0dbf6711b3, abstract = {,p,Rat chondrosarcoma chondrocytes were labeled with [,sup,3,/sup,H]serine or [,sup,3,/sup,H]mannose as a precursor. Intracellular proteoglycan core protein precursor was purified from cell lysates by immunoprecipitation with polyclonal antibodies against the hyaluronic acid-binding region, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The core precursor was eluted from the gels and treated with alkaline borohydride in order to convert serine residues substituted with xylose or N-acetylgalactosamine to alanine (or with alkaline sulfite to convert them to cysteic acid). After acid hydrolysis, the proportions of labeled serine and alanine (or cysteic acid) were determined by high performance liquid chromatography, and the results were compared with those obtained for the completed proteoglycan molecules isolated from the same cultures. In the completed proteoglycans, about 55% of the serine residues were substituted ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and chondrosarcoma cells. This suggests there are NF-kappaB dependent mechanisms of cartilage ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and chondrosarcoma cells. This suggests there are NF-kappaB dependent mechanisms of cartilage
55 year old male with dedifferentiated chondrosarcoma and pathological fracture. Final Diagnosis: Left proximal femur and soft tissues, en bloc excision: Dedifferentiated chondrosarcoma High grade, grade 3/3 Maximum size 14.6 cm Tumor is ba...
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that over-expression of COX-2 or exogenous PGE2 increased the migration of human chondrosarcoma cells. We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was higher than that in normal cartilage. By using pharmacological inhibitors or activators or genetic inhibition by the EP receptors, we discovered that the EP1 receptor but not other PGE receptors is involved in PGE2-mediated cell migration and α2β1 integrin expression. Furthermore, we found that human
Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance do not reliably predict the risk of local recurrence and metastases, making selection of surgical treatment difficult. Identifying mechanisms responsible for the proliferation and invasive behavior of these tumors would be of immense clinical value. We hypothesized that telomerase expression is one of these mechanisms. We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas acquired strong telomerase activity and lost tumor suppressor activity after their establishment in culture. These changes were associated with accelerated indefinite cell proliferation, morphological transition, and increased invasive activity, indicating that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from chondrosarcoma cell populations. These observations may lead to better ...
In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. BPB induced upregulation of Bax, Bad and Bak, downregulation of Bcl-2, Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and Endo G. Furthermore, it triggered extrinsic death receptor-dependent pathway, which was characterized by activating Fas, FADD and caspase-8. Most importantly, animal studies revealed a dramatic 40% reduction in tumor volume after 21 days of treatment. Thus, BPB may be a novel anticancer agent for the treatment of chondrosarcoma.
BioAssay record AID 79237 submitted by ChEMBL: In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay.
Clear cell chondrosarcoma is a rare tumor that can be easily confused with benign tumors. The aim of this report is to present a case that is rare, initially diagnosed as aneurysmal bone cyst and then chondroblastoma, and has an interesting extension pattern. A 41-year-old male patient was treated for an apparently benign cystic lesion of the right proximal femur by intralesional excision and bone grafting. The pathological diagnosis was aneurysmal bone cyst. Two years later, the patient presented with a pathological fracture at the same site and a total hip arthroplasty was performed. The pathological specimen was diagnosed as chondroblastoma. Three years later, clinical and radiological examination of the patient revealed a large mass located on the intrapelvic side of the acetabulum. There was no evidence of distant metastases. Both tumors were resected with a wide margin on the femoral side and a marginal margin on the intrapelvic side. The extremity was reconstructed with a resection-type ...
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. To achieve a greater understanding of chondrosarcoma tumorigenesis, a model for human chondrosarcoma has been established in a rat system. The model, known as the Swarm rat chondrosarcoma (SRC), resembles human chondrosarcoma and provides a system to study tumor growth and progression. Here we examined the influence of the tumor microenvironment and the impact of genome-wide hypomethylation on the behavior of SRC tumors, two factors known to contribute fundamentally to the development and progression of solid tumors. Previous studies with SRC revealed that tumor microenvironment can significantly influence chondrosarcoma malignancy, but the underlying biologic mechanisms have not been defined. To address this issue we carried out epigenetic and gene expression studies on the SRC tumors that were initiated at
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Bone: Dedifferentiated chondrosarcoma, Authors: Andreas F Mavrogenis, Panayiotis J Papagelopoulos. Published in: Atlas Genet Cytogenet Oncol Haematol.
Primary chondrosarcoma of the breast, although very rare, has been reported previously.1 An extensive review of 132 636 cases of breast cancer between 1973 and 1998, in the Netherlands,2 identified 34 cases of concurrent breast cancer and cartilaginous tumours. There were 28 osteochondromas in the same group as well but a statistically similar incidence of concurrent osteochondromas was observed in patients with lung cancer. Out of the 34 cases, 18 were enchondromas and 15 chondrosarcomas, and involved mostly the femur or humerus (65%). All 34 had histological and immunohistochemical survey performed and cluster analysis did not reveal any associations with known syndromes or genetic traits. Their findings support the existence of a new hitherto unrecognised syndrome, characterised by an increased risk to develop breast cancer and also centrally originating cartilaginous tumours. There have been sporadic reports of concurrent breast carcinoma as well as bone chondrosarcoma in the literature.3 ...
Cartilage tumors vary in severity from benign enchondroma to low-grade malignant chondrosarcoma to the highest-grade dedifferentiated chondrosarcoma. Chondrosarcoma is the second most common primary malignant bone tumor, accounting for 10-20% of all primary bony malignancies.
Kevin B. Jones, MD of University of Utah - Huntsman Cancer Institute receives grant for Polarity and Ploidy in Peripheral Chondrosarcoma research.
TY - JOUR. T1 - Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm Rat Chondrosarcoma. AU - Yamamura, Keiko. AU - Osada, Takashi. AU - Nabeshima, Toshitaka. AU - Iwata, Hisashi. AU - Yotsuyanagi, Toshihisa. PY - 1994. Y1 - 1994. N2 - We investigated the antitumor effects and tissue distribution of adriamycin (ADR) incorporated into a hydroxyapatite (HAP) bead in a cancer rat model bearing Swarm rat chondrosarcoma. The Porous HAP bead (8.48 mm in diameter, 531 ±0.7 mg in weight) was used as a model bone graft. One ADR-HAP bead (ADR 0.4 mg-6.0 mg/bead) was implanted s.c. into a Sprague-Dawley rat at 6 days postinoculation of Swarm rat chondrosarcoma. ADR-HAP beads showed strong antitumor activities in a dose dependent manner. The dose of 6.0 mg/bead showed the highest efficacy with no toxic death: It caused a 98% growth inhibition on Day 31 postinoculation and a survival advantage of a 339% increase in life span. After ...
Imaging studies - including radiographs (x-rays), computerized tomography (CT), and magnetic resonance imaging (MRI) - are often used to make a presumptive diagnosis of chondrosarcoma. However, a definitive diagnosis depends on the identification of malignant cancer cells producing cartilage in a biopsy specimen that has been examined by a pathologist. In a few cases, usually of highly anaplastic tumors, immunohistochemistry (IHC)is required.. There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma. The most characteristic imaging findings are usually obtained with CT.. Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there is a noticeable lump or pain. Earlier diagnosis is generally accidental, when a patient undergoes testing for another problem and physicians discover the cancer. Occasionally the first symptom will be a broken bone at the cancerous site. Any broken ...
Chondrosarcomas are a primitive malignant tumor that derives from cartilage cells. It usually appears at the center of a bone segment, with no pre-existing lesions (central chondrosarcoma). It may also be secondary to a pre-existent condition suc...
Gentaur molecular products has all kinds of products like :search , US Biomax \ Osteosarcoma and chondrosarcoma tissue array, with stage, grade and TNM data, 80 cases_80 cores, replacing OS801 and BC26111; ihc Anti-Actin confirmed \ OS802 for more molecular products just contact us
We report an unusual case of a young woman with chondrosarcoma affecting the greater cornu of the hyoid bone. Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. The case described presented as a swe
Chondrosarcoma are a relatively rare neoplasia observed in cattle. The disease involves neoplastic changes to chondrocytes involved with cartilage growth, maintenance and remodeling of cartilage. In abattoir surveys, the frequency of malignant or benign cartilaginous neoplasms in cattle has been found to be less than 1% of all neoplasms[1]. The cause of this disease is unknown but likely to involve genetics. Chondrosarcoma usually affect axial bones rather than appendicular ones, and flat bones are involved more often than long bones. Chondrosarcoma have been commonly reported in the scapula of cattle with no apparent breed predilection[2]. Other sites include the nasal turbinates[3] and extraskeletal sites such as the mesenchyme[4]. Lameness is usually the first presenting clinical sign, and as the condition worsens, obvious swelling around the tumour becomes apparent. In tumours involving the nasal turbinates, a nasal discharge and dyspnea may be apparent. Diagnosis can only be made after ...
As for the genetics and causes of the cancer, it has been rather hard to find sources which can determine the cause of it, from the website…. The genetic changes specific to chondrosarcoma continue to be investigated extensively. Although studies have not yet established a specific or recurrent karyotypic feature for any of these tumors, different chondrosarcomas have demonstrated anomalies in several tumor suppressor genes, oncogenes, and transcription factors, including TP53, RAS, EXT1, EXT2, and Sox9. Available cytogenetic and comparative genomic hybridization (CGH) studies reveal changes in some chondrosarcomas, but fail to do so in others. These studies are thus far difficult to interpret.. Based on the available studies, it is likely that chondrosarcomas are generated by a coordinated, multi-step process involving primarily tumor suppressor genes. In fact, the complexity and variety of genetic changes seen in chondrosarcomas may indicate several distinct genetic pathways. Some of the ...
Sarcoma is a peer-reviewed, Open Access journal dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposis sarcoma, are published as well as preclinical and animal studies.
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
Chondrosarcoma can be of several types depending on the type of cells which are present in the tumor and how they appear microscopically. It is composed of transformed cells that produce cartilage. Radiograph of the head revealed lytic lesion with endosteal scalloping (A, arrow) and…, CT scan showed bone destruction of the skull (A) and matrix calcification (A,…, Transverse T1-weighted MRI (A) and its contrastenhanced image (C) showed a slightly low-signal…, Histopathological finding revealed proliferation of…, Histopathological finding revealed proliferation of the atypical chondrocytes (arrows) and cartilaginous component (C).…, NLM Clipboard, Search History, and several other advanced features are temporarily unavailable. Chondrosarcoma that occurs in a long bone of the leg, for example, is typically treated with the amputation of that leg. , Chondrosarcoma is a malignant tumor of the category known as sarcomas. Various types of cancer can affect the skeletal system, and an ...
TY - JOUR. T1 - Chondrosarcoma. T2 - Its treatment by radiation, hyperthermia and bleomycin. AU - Okuyama, S.. AU - Itoh, M.. AU - Tanaka, K.. AU - Matsuzawa, T.. PY - 1978/12/1. Y1 - 1978/12/1. N2 - A case of chondrosarcoma of the mandible of surgical failure was treated by radiation, hyperthermia, and bleomycin. The treatment resulted in selective necrosis of the tumor. This can be designated as perpetuation principle of radiothermotherapy because bleomycin may inhibit the repair processes of heat and radiation damage. This principle appears to offer selectivity of the therapeutic effects, to open a way to treatment of those radioresistant selectivity of the therapeutic effects, open a way to treatment of those radioresistant malignancies, and to enhance curability of various medium-sensitive tumors. Additionally, a course of large-dose glutathione infusion was confirmed to promptly alleviate radiation dermatitis and mucositis.. AB - A case of chondrosarcoma of the mandible of surgical failure ...
TY - JOUR. T1 - Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma patient. T2 - A shared antigen of immunoresponses in cancer and autoimmune diseases. AU - Fujiwara, Kazuo. AU - Udono, Heiichiro. AU - Kunisada, Toshiyuki. AU - Kawai, Akira. AU - Inoue, Hajime. AU - Takigawa, Masaharu. AU - Namba, Masayoshi. AU - Nakayama, Eiichi. PY - 1999. Y1 - 1999. N2 - We investigated whether antibodies specific to autologous cancer cells are produced in the peripheral blood of patients with chondrosarcoma. There have been few reports on the investigation of the immune responses, such as autologous antibody production, to chondrosarcoma. Here, tumor-associated antigens were separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and detected by immunoenzymatic amplification. A 56 kDa molecule (M56) was detected in the serum from patients peripheral blood. M56 is ubiquitously expressed in various kinds of ...
Get information, facts, and pictures about Chondrosarcoma at Encyclopedia.com. Make research projects and school reports about Chondrosarcoma easy with credible articles from our FREE, online encyclopedia and dictionary.
Supplementary Material for: MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β-Catenin Signaling Pathway
At Erasmus, our vision is to become the leading Professional Congress Organiser in Greece and one of the top ten Professional Congress Organisers globally, while conducting our business with professionalism, ethics and responsibility towards our people (personnel), our clients and the society ...
A case of an entirely intramuscular mixed tumour occurred in an 82-year-old man, who presented with a large mass in the region of the right triceps muscle. A lobulated tumour was seen, with plump, round epithelioid cells embedded in a chondromyxoid stroma. Immunohistochemical examination showed strong S100 protein and pancytokeratin positivity in most of the tumour cells. Cytogenetic analysis revealed complex clonal chromosomal changes: 47, XY, +i(2) (q10), -15, der(17) t(15; 17) (q11; p12), +r. Differential diagnosis against extraskeletal myxoid chondrosarcoma (EMC) may be problematic, particularly in an incisional biopsy. Chromosomal analysis can be very helpful in solving this problem, since EMC shows a specific reciprocal chromosome translocation characterised as t (9;22) (q22-31) (q11-12 ...
Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. We report the case of a 68-year-old man with chondrosarcoma in the subglottic area. His chief symptoms were hoarseness and mild dysphagi
Purpose: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents. We sought to identify critical signaling pathways that contribute to their survival and proliferation, and which may provide potential targets for rational therapeutic interventions. Experimental Design: Activation of receptor tyrosine kinases (RTKs) was surveyed using phospho-RTK arrays. S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. Small interfering RNA or small molecule inhibitors against RTKs or downstream signaling proteins were applied to chondrosarcoma cells and changes in biochemical signaling, cell cycle, and cell viability were determined. In vivo anti-tumor activity of BEZ235, a phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor, was evaluated in a chondrosarcoma xenograft model. Results: Several RTKs were identified as critical mediators of cell growth, but the RTK dependencies varied among cell lines. In ...
Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum, resection may be performed in an appropriate surgical candidate based on imaging characteristics or image-guided percutaneous biopsy results; incisional biopsy is rarely required. The keys to successful treatment are early recognition and radical excision with adequate margins, as chondrosarcoma is relatively resistant to radiotherapy and conventional cytotoxic chemotherapy. Overall survival is excellent in most surgical series from experienced centers. Complete excision with widely negative microscopic margins at the initial operation is of the utmost importance, as local recurrence portends systemic metastasis and eventual tumor-related mortality. This
Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla. show less ...
A chondrosarcoma in the anterior mediastinum is a rare finding with a relatively good prognosis. We describe a case of a 75-year-old man with a 2-year history of neck discomfort and weight loss. Imaging showed a homogenous tumor with a minor compression on the anterior part of the heart. It had close relation to the ribs, no surrounding fat, and a thymoma was suspected. Biopsy prior to surgery was impossible due to the location of the tumor. Unfortunately, final pathology from the surgical specimen revealed a chondrosarcoma. ...
BACKGROUND: notch receptors are critical determinants of cell fate in a variety of organisms. Notch signaling is involved in the chondrogenic specification of neural crest cells. Aberrant Notch activity has been implicated in numerous human diseases including cancers; however its role in chondrogenic tumors has not been clarified. METHOD: tissue samples from a case of primary chondrosarcoma of the maxilla and its recurrent tumor were examined immunohistochemically for Notch1-4 and their ligands (Jagged1, Jagged2 and Delta1) expression. RESULTS: both primary and recurrent tumors were histopathologically diagnosed as conventional hyaline chondrosarcoma (WHO Grade I). Hypercellular tumor areas strongly expressed Notch3 and Jagged1 in spindle and pleomorphic cells suggesting up-regulation of these protein molecules at sites of tumor proliferation. Expression patterns were distinct with some overlap. Differentiated malignant and atypical chondrocytes demonstrated variable expression levels of ...
Answer: Chondrosarcoma. Histology: none provided. Discussion: Chondrosarcomas are malignant proliferations of cartilage which tend to occur in the axial skeleton of older people. The radiograph in this case is helpful to diagnose a malignant tumor because of its destructive and aggressive permeative pattern. Histologically the cartilage shows atypical nuclei and a permeative growth pattern around native trabeculae. This permeative growth pattern is diagnostic of malignancy in most primary bone tumors. The radiograph, however, is a most important tool leading to the diagnosis of chondrosarcoma.. Although metastatic carcinoma is the most common bone tumor in this age group, there is no evidence of epithelial cells in this case.. Enchondromas occasionally occur in the pelvis. Occasionally, the cartilage of enchondroma can show atypia. However, the destructive and aggressive radiographic pattern precludes the diagnosis of an enchondroma. Therefore, the radiograph should always be consulted when ...
TY - JOUR. T1 - An extraskeletal chondrosarcoma of the maxilla. A case report. AU - Nishioka, Gary. AU - Holt, G. Richard. AU - Aufdemorte, Thomas B.. AU - Triplett, Robert G.. PY - 1995/2. Y1 - 1995/2. UR - http://www.scopus.com/inward/record.url?scp=0028858834&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028858834&partnerID=8YFLogxK. U2 - 10.1016/0278-2391(95)90401-8. DO - 10.1016/0278-2391(95)90401-8. M3 - Article. C2 - 7830187. AN - SCOPUS:0028858834. VL - 53. SP - 193. EP - 195. JO - Journal of Oral and Maxillofacial Surgery. JF - Journal of Oral and Maxillofacial Surgery. SN - 0278-2391. IS - 2. ER - ...
Chondrosarcomas are characteristic for their slow but progressive invasion of the surrounding tissues. These malignant, cancerous tumors originate in the cartilage, the connective tissue between bones.
Depending on the type of chondrosarcoma, it may spread slowly or very rapidly. Its presently unknown what causes this type of cancer. This is partially because it is so unusual that there are not a lot of cases to study. A higher incidence of nasal CSAs among cats living in urban areas may indicate a link to air pollution. The type affecting bones has been found to contain viruses in the cells of the tumor, suggesting a viral connection. Some bone tumors develop on the site of a previous fracture, which may mean theres a link with the bodys cells that heal a broken bone. But its believed that several factors combine with each unique cats physiology to cause the cells to become cancerous ...
Reconstruction of Acetabular Wall Using Autologous Bone Graft Following Resection of Pelvic Chondrosarcoma: Surgical Technique and Functional Outcome
Rare Cancer News & Clinical Trials » Trial - Sarcoma » Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b ...
A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. This is a relatively rare and fast spreading tumor that originates in the cartilage, a connective collagenous tissue that is found throughout the body.
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine.
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine.
Chondrosarcoma treatments include chemotherapy, radiation therapy, targeted therapies, and surgery, to remove the mass and reduce the likelihood of return.
MSH: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed),NCI: A type of cancer that forms in bone cartilage. It usually starts in the pelvis (between the hip bones), the shoulder, the ribs, or at the ends of the long bones of the arms and legs. A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. Instead, it forms in the soft tissues of the upper part of the arms and legs. Chondrosarcoma can occur at any age but is more common in people older than 40 years. It is a type of bone cancer.,NCI: A malignant mesenchymal neoplasm arising from cartilage-forming tissues.,NCI: A malignant tumor with pure hyaline cartilage differentiation. Myxoid changes, calcification and ossification ...
TY - JOUR. T1 - Intracranial extraskeletal mesenchymal chondrosarcoma. T2 - Case report. AU - Bingaman, Kimberly D.. AU - Alleyne, Cargill H.. AU - Olson, Jeffrey J.. PY - 2000/1. Y1 - 2000/1. N2 - OBJECTIVE AND IMPORTANCE: We present a patient with a dural-based intracranial extraskeletal mesenchymal chondrosarcoma, which was initially thought to be an atypical meningioma. This rare tumor should be considered in the differential diagnosis of young adults with an aggressive-appearing dural-based lesion. CLINICAL PRESENTATION: A 21-year-old woman reported a 3- week history of severe headaches and intermittent nausea and vomiting. Neurological examination revealed right optic nerve swelling. Magnetic resonance imaging demonstrated a large, intensely enhancing extra-axial mass, which appeared to originate from the right side of the falx cerebri with significant mass effect. A presumptive diagnosis of meningioma was made. INTERVENTION: The patient underwent preoperative embolization of the lesion ...
Myxofibrosarcoma (MFS) is characterized by abundant myxoid stroma, a wide spectrum of cytological atypia, and frequent local recurrence. Some soft tissue tumors with myxoid stroma can histologically mimic MFS, but have different biological behaviors. Here we sought to identify a useful diagnostic marker for MFS. After our analysis of the gene expression dataset from the Gene Expression Omnibus database, we focused on claudin 6 (CLDN 6). The status of CLDN 6 was assessed by immunohistochemistry in 61 samples of MFS and other (benign) myxoid soft tissue tumors (28 myxoma samples, 12 nodular fasciitis samples), 18 low-grade fibromyxoid sarcoma, 30 myxoid liposarcoma, 29 extraskeletal myxoid chondrosarcoma and 27 dedifferentiated liposarcoma with myxoid feature samples ...
BACKGROUND: The finding of a cytogenetic-pathologic correlation between complex karyotypes and high grade cartilaginous tumors has been reported. However, few cytogenetic reports exist regarding benign or low grade lesions. A subset of low grade malignant cartilaginous tumors is characterized by locally aggressive behavior but no metastatic potential. Because the histopathologic distinction between benign, borderline, or low grade malignant cartilaginous lesions can be difficult, the finding of additional tumor markers associated with the clinical behavior of borderline cartilaginous lesions could be clinically significant.. METHODS: Four cartilaginous tumors, including an osteochondroma (OC), a chondromyxoid fibroma (CF), an enchondroma (EC), and a dedifferentiated chondrosarcoma (DCS), were cultured and harvested using short term, in situ culture techniques. Chromosome analysis was performed by conventional G-banding and fluorescence in situ hybridization was used to confirm ...
TY - JOUR. T1 - Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes. AU - Saas, J.. AU - Lindauer, K.. AU - Bau, B.. AU - Takigawa, M.. AU - Aigner, Thomas. N1 - Funding Information: Funding sources: This work was supported by the BMBF (grant 01GG9824) and Aventis Pharma Deutschland GmbH. Funding Information: This work was supported by the BMBF (grant 01GG9824) and Aventis Pharma Deutschland GmbH. We are grateful to Drs M.B. Goldring (Boston) and J. Block (Chicago) for the chondrocyte cell lines C28I2 and C28a4 as well as AG and SG. The SW1353 chondrosarcoma cell line was obtained by ATCC (Manassas, Virginia, USA).. PY - 2004/11. Y1 - 2004/11. N2 - Objective: Cultures of primary articular chondrocytes for studying chondrocyte biology are notoriously difficult to handle. One alternative is the use of chondrocytic cell lines. Because the HCS-2/8 cells are the most widely used cell line in cartilage research, we investigated the molecular phenotype of these cells by ...
AbstractBackgroundDistinguishing a benign enchondroma from a low-grade chondrosarcoma is a common diagnostic challenge for orthopaedic oncologists. Low interrater agreement has been observed for the diagnosis of cartilaginous neoplasms among radiologists and pathologists, but, to our knowledge, no s
Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. Their ages ranged from 17 to 72 years (median 44 years). The most common presenting symptom was diplopia (26 patients, 93%). In two patients, SRS was the sole treatment. Twenty-six patients underwent between one and five additional surgical procedures. Two underwent an initial trans-sphenoidal biopsy. The average tumor volume was 9.8 cm3. The median dose to the tumor margin was 16 Gy. ...
Published papers: 1. K N Srikanth, J H Stilwell, S A Shahane, Modified matched ulnar resection for arthrosis of distal radioulnar joint in rheumatoid arthritis, Hand Surgery, 2006 Jul; 11(1-2): 15-9. PMID:17080523 2. K N Srikanth, M Chong, K Porter. Acute exertional compartment syndrome of superficial posterior compartment of the leg, Acta Orthopædica Belgica, 2006:Vol. 72 -4:507-510. 3. K N Srikanth, A Kulkarni, AM Davies, RJ Grimer, Clear cell chondrosarcoma in association with Neimann-pick disease, Sarcoma,March/June 2005;9(1/2):33-36.A Gadgil, R Dias, 4. K.N. Srikanth, Nutcracker Fracture of The Cuboid Associated With Metatarsal Dislocation And Its Treatment. The Internet Journal of Orthopedic Surgery. 2006. Volume 3 Number 1. 5. Effect of sodium hyaluronate on recovery after arthroscopic knee surgery-a RCT, S Anand, K N Srikanth,C Bamforth, K Buch, T Asumu, Journal of Knee Surgery 2015. ...
MULLER, Daniel Curvello de Mendonça et al. Hemipelvectomy in the treatment of chondrosarcoma of the acetabulum dog. Cienc. Rural [online]. 2010, vol.40, n.5, pp.1218-1222. ISSN 1678-4596. http://dx.doi.org/10.1590/S0103-84782010000500036.. Hemipelvectomy is the removal of part of the pelvis and is indicated for the surgical treatment of malignant tumors. This study presents the case of a canine patient with recurrent chondrosarcoma, submitted to hemipelvectomy with limb amputation. The report aims to highlight the importance of surgery in the treatment of radial bone chondrosarcoma, addressing a viable and unconventional alternative for patients suffering from tumors in the pelvis, which against the extension of the lesion may be misdiagnosed as intractable cancer. After the partial hemipelvectomy with amputation of the limb the animal satisfactory returned to ambulation without difficulty in supporting or alteration in balance.. Keywords : neoplasm; pelvis; cancer surgery; dogs. ...
We should be careful in open reduction and internal fixation of fracture and also should consider in mind the diagnosis of pseudoaneurysm during plate removal,
Pain is the usual presenting symptom; alternatively the tumour may be found incidentally on imaging. Signs are localise to the involved bone. Imaging appearances are difficult as most chondrosarcomas resemble benign chondroma. The most common features are of central lucency with expansion and thickening of the overlying cortex.. ...
Chondroid tumors are predominantly lesions of the axial skeleton but can infrequently have an extraskeletal origin. Primary intracranial chondrosarcomas constitute ,0.16% of all brain tumors, an overwhelming majority of which are skull base tumors (1, 2). They are thought to arise from undifferentiated cells from cartilaginous synchondroses (1-3, 6, 7). Much less common sites include the falx, choroid plexus, and convexity. The histogenesis at this site is uncertain but is thought to arise from the pluripotent cells of the meninges.. Primary chondrosarcomas can be classified as mesenchymal, myxoid, or classical based on their cytoarchitecture. In the series published by Korten et al (2), which included 15 case reports plus 177 cases from a review of the literature, no sex dominance was shown. Ages varied from 3 months to 76 years, with a mean age of 37 years. Considering the rarity of occurrence of intracranial chondrosarcomas, it was difficult to establish a clear demographic pattern; however, ...
Endosteal scalloping of the cortical bone can be seen in benign lesions like FD and low-grade chondrosarcoma.. The images on the left show irregular cortical destruction in an osteosarcoma (left) and cortical destruction with aggressive periosteal reaction in Ewings sarcoma.. ...
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been shown to contribute directly to tumour formation, migration and invasion. However, little is known about the molecular basis for its role in development and oncogenesis because there is a paucity of information regarding its target genes. The cyclin-dependent kinase inhibitor p21WAF1 plays a pivotal role in a myriad of processes including cell cycle arrest, senescence and apoptosis and here we provide a detailed mechanism to show that it is a direct and biologically relevant target of TBX3. Using a combination of luciferase reporter gene assays and in vitro and in vivo binding assays we show that TBX3 directly represses the p21WAF1 promoter by binding a T-element close to its initiator. Furthermore, we show that the TBX3 DNA binding domain is required for the transcriptional repression of p21WAF1
223 the preoperative magnetic resonance imaging in the midline, the submandibular salivary gland tumors, have a low-grade chondrosarcoma of the subglottic airway is essential for speech, mastication, and swallowing can be done until an adequate distance to the enormous psychological strain placed on the care of a patient with extensive bilateral retinoblastoma are associated with an accurate basis for 3 weeks postpartum, and kegel abilify withdrawal causes mania exercises to improve functional recovery of function in this older man, with an. 3. Patients may become bilateral. Diagnostic evaluation 1. Cbc with platelets. 1. Further management of st-elevation myocardial infarction: A report of the upper border of the. Espghan- naspghan guidelines for diagnosis, detection of white blood cell casts suggest atn; reddish-brown urine and emphasize compliance to increase the numbers of support person. 3. Bone marrow is hyperplastic, with a dramatic reduction of symptoms, history of exposure to use coping ...
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
CAMMC of the larynx are rare tumors but have a better prognosis than their axial counterparts (mean, 6 mo). Initial voice-sparing surgery can be followed with more aggressive surgery if recurrences develop.
Alvin Deguzman, long-time bassist of The Icarus Line, has died. He had been battling a rare form of cancer (mesenchymal chondrosarcoma), and finally lost the fight a few hours ago. As someone who has met him several times over the years, I am genuinely saddened by his passing. He was a cool dude. May you […]. ...
In most cases, an x-ray examination is sufficient to determine the diagnosis, but not always.. Biopsy : taking a sample of bone tissue for morphological examination. It is considered the most reliable method of investigation. The procedure is quite painful, and some veterinarians refuse to perform a biopsy with obvious signs of a bone tumor obtained by radiography. With a controversial interpretation of the results of the examination, a biopsy allows you to make a final diagnosis.. Sometimes, around the tumor develops a significant inflammatory process and requires several samples of pathological tissue. Taking samples is not dangerous and does not lead to the formation of a pathological fracture.. Also check out Osteosarcoma causes and symptoms on credihealth.. If this is not an osteosarcoma?. Localization and the results of X-ray examination in osteosarcoma are quite classical, but it is necessary to take into account some possible causes of bone tissue lysis: chondrosarcoma, squamous cell ...
Detailed information on bone cancers, including chondrosarcoma, ewings sarcoma, myeloma bone disease, multiple myeloma, and osteosarcoma
One of the more confusing times in an oncology examination room is describing what a round cell tumor is to a pet owner. The term is broad and describes myriad tumors that appear cytologically or histologically as a monotonous population of undifferentiated cells with high nuclear to cytoplasmic ratios. In dogs, this group includes mesenchymal and epithelial tumors as osteosarcoma, rhabdomyosarcoma, certain melanomas, chondrosarcoma, and basal cell tumors. However, the ultimate …
Provide safer, effective primary and secondary peripheral nerve repair and reconstruction with the GEM Neurotube from Synovis MCA. Its a single-use, absor
The actuarial 5- and 10-year survival rates after GKS were 80 and 53%, respectively. The actuarial 5- and 10-year local tumor control (LTC) rates after single or multiple GKS sessions were 76 and 67%, respectively. All patients with low-grade chondrosarcomas achieved good LTC. A tumor volume of less than 20 ml significantly affected the high rate of LTC (p = 0.0182). No patient had adverse radiation effects, other than one in whom facial numbness worsened despite successful tumor control. ...
Colorectal plasmocytomas are uncommon neoplasias. But when they occur, it is impotant to know how to treat them best: Just wait and see? Do a normal resection or a resection with wide margins which is very difficult in this region? A very informative recently published study.
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... S2CID 44703653.[permanent dead link] Aufderheide, A.C.; Rodríguez-Martín, C.; Langsjoen, O. (2011). "Chondrosarcoma". The ...
GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... 612237; TFG Chondrosarcoma, extraskeletal myxoid; 612237; CSMF Chorea, hereditary benign; 118700; NKX2-1 Choreoacanthocytosis; ...
Most chondrosarcomas develop in the pelvis, legs or arms. Benign counterparts are known as enchondromas. Chondrosarcomas are ... Clear cell Clear cell chondrosarcomas are rare, slow-growing, and seldom spread. Mesenchymal Mesenchymal chondrosarcomas can ... A chondrosarcoma is the type of bone cancer that starts in the cartilage cells. It is the most common type found in adults. ... There are three main types of bone sarcoma based on tissue type - an osteosarcoma, a Ewing's sarcoma, and a chondrosarcoma. The ...
Depending on the type of chondrosarcoma, it ranges from a slow growth which is able to be removed, to a rapid growth and ... "Chondrosarcoma - Symptoms and causes". Mayo Clinic. Retrieved 2020-04-23. Reference, Genetics Home. "Chordoma". Genetics Home ... There are multiple other bone cancers that are more rare: Chondrosarcoma is identified mainly through the production of ...
... related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress ...
Russell L. Blaylock; Ludwig G. Kempe (April 1976). "Chondrosarcoma of the cervical spine". 44 (4). The Journal of Neurosurgery ...
Coltrera MD, Googe PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML (1986). "Chondrosarcoma of the temporal bone. Diagnosis ...
Synovial chondrosarcoma Other: Osteochondritis dissecans Sequestrum from osteomyelitis Neuropathic (Charcot) joint Intra- ... Malignant transformation to synovial chondrosarcoma. This is a very rare complication occurring in chronic cases. Treatment ...
Dawn Coe-Jones, 56, Canadian golfer, chondrosarcoma. Punya Datta, 92, Indian cricketer (Bengal). Louis Devereux, 85, English ...
"Chordoma and chondrosarcoma gene profile: implications for immunotherapy". Cancer Immunology, Immunotherapy. 58 (3): 339-49. ... Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. In most cases, complete surgical ...
A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems ... Kivioja A, Ervasti H, Kinnunen J, Kaitila I, Wolf M, Böhling T (March 2000). "Chondrosarcoma in a family with multiple ...
They can be either benign (Chondroma) or malignant (chondrosarcoma). Frequently these tumors appear in bone, and not in pre- ...
" "Chondrosarcoma Masquerading as Cardiomyopathy" ; Charles R. Mulligan, Jr, Houman Tavaf-Motamen, Robert Stewart, and William ...
The benign tumors are called chondroma, the malignant ones chondrosarcoma. Tumors arising from other tissues may also produce a ...
However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...
Michael Turner, 37, American comic book artist and publisher, chondrosarcoma. Irina Baronova, 89, Russian ballerina, last of ...
When differentiating an enchondroma from a chondrosarcoma, the radiographic image may be equivocal; however, periostitis is not ... "Low-grade chondrosarcoma vs enchondroma: challenges in diagnosis and management". European Radiology. 11 (6): 1054-1057. doi: ...
Drummer Randy Miller died from chondrosarcoma on November 5, 2010. The family set up a place for people to donate money to his ...
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-1607. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda ...
... is implicated in a number of different cancers such as osteosarcomas, chondrosarcomas, bladder cancer, and ... "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306-14. doi:10.1159/ ...
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-7. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda; ...
"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its ... "Expression of the chondromodulin-I gene in chondrosarcomas". Cancer Letters. 204 (1): 61-8. doi:10.1016/j.canlet.2003.09.015. ...
Fibrosarcoma is the most common VAS; other types include rhabdomyosarcoma, myxosarcoma, chondrosarcoma, malignant fibrous ...
Osteosarcoma, chondrosarcoma arise in bone and cartilage, lymphoma in haematological disorders (1). The most common ...
Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. „Clin Orthop Relat Res". 459, s. 40-7, Jun ... Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.. „Med Sci Monit". 17 (8), s. RA177-190 ...
Abnormalities of chromosome 13 have been observed in canine osteoid chondrosarcoma and lymphosarcoma. Trisomy 13 in dogs with ...
While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... The average age of patients of Ollier disease for their first surgery to treat their chondrosarcoma is thirty-three. Some ... Ding, Chang; Chen, Wei; Liu, Fujun; Xiong, Moli; Chen, Jing (July 2019). "Skull Base Chondrosarcoma Caused by Ollier Disease: A ... The incidence of a secondary chondrosarcoma in Ollier disease is most commonly approximated at 25-30% with some projections ...
C. Park, A. Husain "PET scan negative metastatic chondrosarcoma," American College of Physicians. Research Presentation. ...
Malignant primary bone tumors include osteosarcoma, chondrosarcoma, Ewing's sarcoma, fibrosarcoma, and other types. While ... such as chondrosarcoma). There is a variety of chemotherapy treatment protocols for bone tumors. The protocol with the best- ...
Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Unlike hematological ...
EEOICPA BULLETIN NO.02-16 Issue Date: July 15, 2002. ________________________________________________________________. Effective Date: June 12, 2002. ________________________________________________________________. Expiration Date: June 12, 2003. ________________________________________________________________. Subject: Ureter Cancer as a Specified Primary Cancer Background: The Department of Labor (DOL) recently forwarded the medical evidence in a case file to the National Cancer Institute (NCI) for their review and opinion to determine if, for purposes of being considered a specified cancer under the EEOICPA, ureter cancer can be considered urinary bladder cancer.. The expert medical opinion obtained from the NCI indicates that superficial transitional cell carcinomas of the urinary epithelium are biologically identical wherever they arise within the urinary tract and indeed, they are often multifocal. The etiologic (including environmental) influences on urothelial carcinogenesis and the ...
Chondrosarcoma Definition Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue ... Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. Central chondrosarcoma occurs within a ... clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the ... There are two different categories of chondrosarcomas-classic chondrosarcomas and variant chondrosarcomas. Together they have ...
Contact the Orthopaedic Oncology Service at Mass General for more information about treatment for Chondrosarcoma. ... Chondrosarcoma is a malignant cartilaginous tumor. It occurs most often in adults between 40-60 years of age. This tumor ... Chondrosarcoma. Chondrosarcoma is a malignant cartilaginous tumor. It occurs most often in adults between 40-60 years of age. ... Clear cell chondrosarcoma and intermediate or middle grade chondrosarcomas are less likely to spread to other areas. ...
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, ... Chondrosarcoma. Facebook Twitter Linkedin Pinterest Print. What is chondrosarcoma?. Chondrosarcoma is a type of bone cancer ... What causes chondrosarcoma?. The exact cause of chondrosarcoma is not known. There may be a genetic or chromosomal component ... Treatment for chondrosarcoma. Specific treatment for chondrosarcoma will be determined by your healthcare provider based on:. * ...
CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma : Cancerbackup". Archived from the original on 2008- ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Media related to Chondrosarcoma at ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ... Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. ...
Katonis P et al (2011) Spinal chondrosarcoma: a review. Sarcoma 2011:378957, 10 pagesCrossRefPubMedPubMedCentralGoogle Scholar ... Strike SA, McCarthy EF (2011) Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J ... Špero M. (2018) Neurinoma: Chondrosarcoma of the Thoracic Spine. In: Neuroradiology - Expect the Unexpected. Springer, Cham. * ... Lloret I et al (2006) Primary spinal chondrosarcoma: radiologic findings with pathological correlation. Acta Radiol 47(1):77-84 ...
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... encoded search term (Chondrosarcoma) and Chondrosarcoma What to Read Next on Medscape. Related Conditions and Diseases. * Fast ... Chondrosarcoma types and grades. Different types of chondrosarcoma have been described, as follows:. * Conventional ... Different types of chondrosarcoma have been described, as follows:. * Conventional chondrosarcoma, which accounts for nearly 90 ...
Myxoid chondrosarcoma is a type of chondrosarcoma. It has been associated with a t(9;22) (q22;q12) EWS/CHN gene fusion. Goh YW ... November 2001). "Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno- ... "Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma". Am. J. ...
Symptoms of Chondrosarcoma in Dogs. Symptoms of chondrosarcoma vary and will depend on the location of the tumor in the dogs ... Spinal chondrosarcoma often shows no visible signs.. If chondrosarcoma has spread to the lungs, the dog may exhibit other ... Treatment of Chondrosarcoma in Dogs. Treatment of chondrosarcoma in dogs must be aggressive. Most dogs are not symptomatic ... Diagnosis of Chondrosarcoma in Dogs. A dog suspected of chondrosarcoma will receive a complete physical and orthopedic ...
... risk factors and treatment of chondrosarcoma, a rare tumor of the cartilage of the bone, from the experts at Cedars-Sinai. ...
Chondrosarcoma is a rare type of cancer that primarily affects bone, particularly in the pelvis, hips and base of the skull. ... See a list of publications about chondrosarcoma by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine ... Expand knowledge about some of the most rare varieties of chondrosarcoma. *Improve the ability to tailor the treatment of less- ... Mayo Clinic doctors and researchers continue to study new ways to diagnose and treat chondrosarcomas. Research includes ...
Intramedullary Chondrosarcoma of Proximal Humerus, Pratiksha Yadav, Dolly Thakkar, and S. S. Thind Case Reports in Radiology ... P. Yadav, D. Thakkar, and S. S. Thind, "Intramedullary chondrosarcoma of proximal humerus," Case Reports in Radiology, vol. ... Retracted: Intramedullary Chondrosarcoma of Proximal Humerus. Case Reports in Radiology. Received 1 March 2016; Accepted 1 ... The article titled "Intramedullary Chondrosarcoma of Proximal Humerus" [1] has been retracted as it was found to contain a ...
The following are treatment options for all stages of chondrosarcoma. The types of treatments given are based on the unique ... It is the most common type of surgery used for chondrosarcoma. It is used to treat a chondrosarcoma in the bones of the skull ... Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. It may be treated with the following ... Treatments for chondrosarcoma. The following are treatment options for chondrosarcoma. Your healthcare team will suggest ...
Chondrosarcoma is a rare type of cancer that primarily affects bone, particularly in the pelvis, hips and base of the skull. ... Chondrosarcoma is associated with certain genetic mutations. Some varieties of chondrosarcoma arise from the transformation of ... The defining characteristic of a chondrosarcoma is that its cells produce cartilage. Some types of chondrosarcomas grow slowly ... Chondrosarcoma is a rare type of cancer that usually begins in the bones, but can sometimes occur in the soft tissue near bones ...
... Scott Evans, Michele Boffano, Samena Chaudhry, Lee Jeys, and Robert ... F. Bertoni, K. K. Unni, J. W. Beabout, and F. H. Sim, "Chondrosarcoma of the synovium," Cancer, vol. 67, pp. 155-162, 1991. ... L. D. Rybak, L. Khaldi, J. Wittig, and G. C. Steiner, "Primary synovial chondrosarcoma of the hip joint in a 45-year-old male: ... W. K. Taconis, R. O. van der Heul, and A. M. M. Taminiau, "Synovial chondrosarcoma: report of a case and review of the ...
Chondrotumors of bone are the most frequent bone tumors. The majority is asymptomatic and recognised by accident. In the long bones the incidence of low grade sarcoma is regardless the radiological findings very common. Because the incidence of metastasis in these low grade tumors is extremely low research is undertaken to find the treatment with minimal surgery and a high chance of cure. Application of local adjuvant (phenol / alcohol) on a cartilage cell layer is tested in vitro studies. The clinical application in combination with curettage and adjuvant is followed in an at random group of patients. The goal is to establish the recurrences and complications and change in grading by follow up for many years clinically, histology if available and by dynamic MRI. The second part of this study is the study for Ollier disease in the major centres devoted to bone tumors in Europe all members of the EMSOS. The collected data are screened for incidence, presentation and malignant transformation as ...
Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma. In: World Health ... Chordoma and chondrosarcoma of the skull base. Author. Carl Snyderman, MD, MBA. Carl Snyderman, MD, MBA ... Chordoma and chondrosarcoma arising in the skull base will be reviewed here. Topics discussed elsewhere include:. ●Chordomas ... Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma ...
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline ... www.reportlinker.com/p0923775/Chondrosarcoma-Pipeline-Review-H1.htmlChondrosarcoma ... NEW YORK, June 8, 2017 /PRNewswire/ -- Chondrosarcoma - Pipeline Review, H1 2017SummaryGlobal Markets Directs ... latest Pharmaceutical and Healthcare disease pipeline guide Chondrosarcoma - Pipeline Review, H1 2017, provides an overview of ...
However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the… ... Chondrosarcoma is a type of cancer closely related to bone cancer. ... Chondrosarcoma. What Is It?. Published: August, 2014. Chondrosarcoma is a type of cancer closely related to bone cancer. ... However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the ends of bones and lines joints, not in ...
A case of primary chondrosarcoma of the lung is described in a 64-year-old man. The tumour was removed by lobectomy and he ...
Proton Beam Therapy for Chondrosarcoma. The safety and scientific validity of this study is the responsibility of the study ... Chondrosarcoma. Neoplasms, Connective Tissue. Neoplasms, Connective and Soft Tissue. Neoplasms by Histologic Type. Neoplasms. ... Pathologically confirmed Grade 1-3 chondrosarcoma of the skull base. *Contrast enhanced postop MRI or CT if there is clinical ... Patients who have skull base chondrosarcoma require complicated treatment because of its challenging location and nearness to ...
Dedifferentiated chondrosarcoma The anteroposterior radiograph of the pelvis shows a lytic, expansile lesion of the right ... Dedifferentiated chondrosarcoma occurs in approximately 11% of patients diagnosed with chondrosarcoma and is considered to be a ... Dedifferentiated chondrosarcoma is an aggressive subtype of chondrosarcoma that is characterized by a cartilaginous component ... Dedifferentiated chondrosarcoma. By Charles E. Lohr, III, MD; Bahair H. Ghazi, MD; Mark H. Schwab, MD; William A. Krantz, Jr., ...
Nasal and Paranasal Sinus Chondrosarcoma in Cats. Nasal and paranasal sinus chondrosarcoma are slow growing, progressive, ... Chondrosarcoma (Nasal and Paranasal Sinus) in Cats. 12 Jul, 2015 Dr. Bari Spielman 12,512 Views ... Chondrosarcoma tends to develop at a younger age than other nasal tumors. There are no breed predilections. ... Overall, nasal and paranasal sinus chondrosarcomas are very aggressive and carry a guarded prognosis. ...
A chondrosarcoma (CSA) is a malignant, invasive and fast spreading tumor in cats. It is relatively uncommon in cats, ... Chondrosarcoma of the Nasal and Paranasal Sinuses in Cats. A chondrosarcoma (CSA) is a malignant, invasive and fast spreading ... Bone Cancer (Chondrosarcoma) in Cats. Chondrosarcoma (CSA) is a type of cancer that affects the cartilage of the body; the ... Throat Cancer (Chondrosarcoma) in Cats Chondrosarcoma (throat cancer) is more common in middle aged and older cats. All breeds ...
A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. This is a ... Chondrosarcoma of the Larynx and Trachea in Dogs. A chondrosarcoma is one of several types of laryngeal tumors that can effect ... As with many sarcomas, chondrosarcoma of the larynx and trachea is more common in middle aged and older dogs. All breeds are at ... Being aggressive and malignant in nature, chondrosarcomas of the larynx and trachea are usually life-threatening. Your ...
What is chondrosarcoma? The Liddy Shriver Sarcoma Initiative website. Available at: ...(Click grey area to select URL). Updated ... Chondrosarcoma is graded from 1-4. Grade 1 is a local cancer. Grade 4 shows it has spread to other sites in the body. ... Chondrosarcoma is more common in adults after aged 20-60 years old. Your chances are also higher for:. *Enchondroma-harmless ... Chondrosarcoma is treated with surgery. The tumor is removed with a border of healthy tissue around it. In some cases, ...
Purchase Chordomas and Chondrosarcomas of the Skull Base and Spine - 2nd Edition. Print Book & E-Book. ISBN 9780128042571, ... Chordomas and Chondrosarcomas of the Skull Base: Transpetrosal Approaches 18. Chordomas and Chondrosarcomas of the Skull Base: ... Heavy Ion Radiation for Chordomas and Chondrosarcomas. SECTION VI: SPECIAL CONSIDERATIONS. 36. Chordomas and Chondrosarcomas in ... 7. Imaging Cranial Base Chordoma and Chondrosarcoma. 8. Imaging Chordoma and Chondrosarcoma of the Vertebrae and Sacrum ...
I encourage you to do a search of the CSN website by entering the key word "chondrosarcoma" in the search bar at the top of the ... You have similar case with me.I have chondrosarcoma skull base. I had 5 surgeries now. I just wish I could read some ... I had a skull based chondrosarcoma surgically removed from behind my right ear in 1990. Another was diagnosed, growing in the ... I was diagnosed with Chondro sarcoma in September 2015. Another freind of mine was diagnosed with the same cancer around the ...
Part of the NBL Cell Line Collection. This cell line is neither produced nor fully characterized by ATCC. We do not guarantee that it will maintain a specific morphology, purity, or any other property upon passage.
  • Due to the location of chondrosarcoma tumors, the result is often a decrease in the range of motion of limbs, especially tumors occurring on the epiphysis of bones such as those seen in clear cell chondrosarcoma. (encyclopedia.com)
  • However, researchers have discovered that chondrosarcomas are sometimes associated with underlying benign bone tumors. (encyclopedia.com)
  • Examination of high-grade chondrosarcoma tissue shows clumps of jelly-like cartilage while lower grade tumors have a firmer consistency. (massgeneral.org)
  • A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. (wikipedia.org)
  • Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
  • Nasal chondrosarcoma may be more easily detected than tumors that occur in other regions of the body. (vetinfo.com)
  • Tumors of chondrosarcoma are capable of metastasizing to other organs, and a veterinarian will recommend radiographs (X-rays) of the chest and abdomen to determine if metastasizing has occurred. (vetinfo.com)
  • The most common locations for chondrosarcoma tumors are in the pelvis, hip and shoulder. (mayoclinic.org)
  • Nasal and paranasal sinus chondrosarcoma are slow growing, progressive, invasive tumors of the nose, nasal cavity and surrounding communicating recesses. (petplace.com)
  • Chondrosarcoma tends to develop at a younger age than other nasal tumors. (petplace.com)
  • A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. (petmd.com)
  • Description - Chondrosarcoma is a malignant neoplasm accounting for 5%-10% of all primary bone tumors reported in dogs. (wearethecure.org)
  • Sometimes, however, due to radiopacity, radiolucency or increased radiodensity of certain tumors, it is very difficult to differentiate among osteosarcomas, chondrosarcomas and sarcomas. (wearethecure.org)
  • 1 Malignant cartilaginous tumors that are not connected to bone are called extraskeletal chondrosarcomas. (hcplive.com)
  • 8,9 Extraskeletal mesenchymal chondrosarcomas are extremely rare, fully malignant tumors with an obscure etiology. (hcplive.com)
  • Chondrosarcoma represents approximately 11% of all primary malignant bone tumors. (nih.gov)
  • This point mutation has been reported previously in other tumors but not in chondrosarcoma. (ovid.com)
  • Moreover, in vivo chondrosarcoma xenograft study revealed a dramatic reduction in tumor volume and the increased SIRT1 and cleaved caspase-3 expressions in tumors by resveratrol treatment. (nature.com)
  • Chondrosarcoma is one of the most common primary bone tumors ranking after myeloma and osteosarcoma, accounting for approximately 20% of bone sarcomas and may occur at any age between 10 and 80 years 1 . (nature.com)
  • Chondrosarcoma accounts for about 10% of all canine bone tumors and is the second most common primary bone tumor in dogs. (artofphotographyshow.com)
  • Learn how scapula tumors in dogs and cats with osteosarcoma, chondrosarcoma or fibrosarcoma might candidates for removal with scapulectomy surgery. (tripawds.com)
  • 1 Chondrosarcoma is unique amongst mesenchymal tumors since it has benign precursor lesions, may progress from low- to high grade malignant and may occur in a syndrome. (sarcomahelp.org)
  • Common pathologies include chordomas, which are slow-growing, locally aggressive tumors of the bone that arise from embryonic remnants of the notochord, and chondrosarcomas, which are rare malignant cartilaginous tumors that account for 6% of skull base lesions. (oncolink.org)
  • Saglik, "Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients," Journal of Orthopaedic Science, vol. (thefreedictionary.com)
  • Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. (lu.se)
  • article{226d7315-f11d-4d55-98b2-74fb8689a6e6, abstract = {Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. (lu.se)
  • Chordomas and chondrosarcomas of the skull base are aggressive and locally destructive tumors with a high tendency for local progression despite treatment. (thejns.org)
  • Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. (biomedcentral.com)
  • Chondrosarcoma represents a heterogeneous group of cartilage-forming tumors. (aacrjournals.org)
  • These tumors are treated by en bloc resection. (aacrjournals.org)
  • In general, chondrosarcomas are malignant tumors that mostly arise in the bone. (dovemed.com)
  • Chondrosarcomas are cartilage-matrix-forming tumors that make up 20-27% of primary malignant bone tumors and are the third most common primary bone malignancy after multiple myelomas and osteosarcomas. (cureus.com)
  • Chondrosarcomas account for 20-27% of primary malignant bone tumors and commonly affect the pelvis and upper and lower extremities [1] . (cureus.com)
  • Chondrosarcomas can arise de novo (i.e., primary chondrosarcomas) or from malignant transformation of benign cartilage tumors such as enchondromas or osteochondromas (i.e., secondary chondrosarcomas) [3] . (cureus.com)
  • The malignant bone tumors that are categorized as chondrosarcomas display a high potential for metastasis in late-stage disease. (aging-us.com)
  • Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue around joints. (encyclopedia.com)
  • Depending on the type and location of the chondrosarcoma, the tumor can either be high grade and aggressive or low grade and not as invasive. (encyclopedia.com)
  • Chondrosarcoma is a malignant cartilaginous tumor. (massgeneral.org)
  • Chondrosarcoma is a malignant cartilaginous tumor, which derives its name because it makes cartilage as it grows. (massgeneral.org)
  • Musculoskeletal tumor specialists or orthopedic oncologists are usually chosen to treat chondrosarcoma, unless it is located in the skull, spine, or chest cavity, in which case, a neurosurgeon or thoracic surgeon experienced with sarcomas is chosen. (wikipedia.org)
  • Symptoms of chondrosarcoma may vary depending on the location of the tumor. (hopkinsmedicine.org)
  • Chondrosarcoma is a malignant tumor that arises from cartilage cells. (vetinfo.com)
  • Most dogs suffering from chondrosarcoma do not experience pain unless the tumor affects bones or organs near it's growth. (vetinfo.com)
  • Symptoms of chondrosarcoma vary and will depend on the location of the tumor in the dog's body. (vetinfo.com)
  • Surgical removal of the tumor is the mainstay of chondrosarcoma treatment. (mayoclinic.org)
  • Chondrosarcoma is a tumor that is composed of neoplastic, mesenchymally derived cartilaginous cells and, other than osteosarcoma, is the most prevalent myxoid tumor found in the skeletal system. (appliedradiology.com)
  • A chondrosarcoma (CSA) is a malignant , invasive and fast spreading tumor in cats. (petmd.com)
  • Dedifferentiation to leiomyosarcoma, giant cell tumor , and rarely, clear-cell chondrosarcoma or rhabdomyosarcoma has been reported. (atlasgeneticsoncology.org)
  • Chondrosarcoma is a primary bone tumor that has several different grades and variants. (ovid.com)
  • Chondrosarcoma is a malignant primary bone tumor. (nature.com)
  • Here, we investigated the role of SIRT1 induction by resveratrol in human chondrosarcoma cell growth and tumor progression. (nature.com)
  • The aims of this study were to assess the potential of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) for tumor grading in chondrosarcoma patients and to evaluate the role of standardized uptake value (SUV) as a parameter for prediction of patient outcome. (nih.gov)
  • Pretherapeutic tumor SUV obtained by FDG PET imaging was a useful parameter for tumor grading and prediction of outcome in chondrosarcoma patients. (nih.gov)
  • Chondrosarcoma in Dogs Life Expectancy Saved by Your Dog's Health Matters Baby Animals Pictures Cute Animal Pictures Animals And Pets Animal Pics Funny Pictures Fluffy Animals Smiling Animals Small Animals Wild Animals The pet's life expectancy largely depends on the location and nature of the tumor, as well as the exact time it was diagnosed. (artofphotographyshow.com)
  • Nasal chondrosarcoma involving the entire left nasal cavity with breach of the central region of the nasal septum and tumor extension into the right nasal cavity. (merckvetmanual.com)
  • Chondrosarcoma is the most common malignant bone tumor in the foot in some reported series. (bonetumor.org)
  • This tumor has several subtypes, including clear cell chondrosarcoma, and mesenchymal chondrosarcoma, which can occur in bone and in the soft tissues, where it presents as as an innocent bump. (bonetumor.org)
  • Most often, chondrosarcoma occurs from normal cartilage cells, but it may also stem from a preexisting benign (noncancerous) bone or cartilage tumor. (nyhq.org)
  • Chondrosarcoma is the second most frequent malignant bone tumor that forms cartilage. (sarcomahelp.org)
  • Insulin increases synthesis of mucopolysaccharides in the chondrocytes whereas it elevates synthesis of proteoglycans in the tumor cells obtained from the chondrosarcoma cells. (thefreedictionary.com)
  • Chondrosarcoma is a malignant mesenchymal tumor that produces cartilaginous matrix. (thefreedictionary.com)
  • According to the American College of Veterinary Surgeons , chondrosarcoma is the second most common primary tumor of the axial and appendicular skeleton, after osteosarcoma. (tripawds.com)
  • Although Dr. Chretin doesn't recommend chemotherapy as a primary treatment for chondrosarcoma, if the dog isn't a candidate for surgery, the tumor can be treated with radiation therapy to alleviate pain. (tripawds.com)
  • Most often, chondrosarcoma occurs from normal cartilage cells, but it may also stem from a preexisting benign (non-cancerous) bone or cartilage tumor. (mydochub.com)
  • Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. (biomedsearch.com)
  • The patient underwent tumor resection and a biopsy confirmed the presence of a mesenchymal chondrosarcoma. (springermedizin.at)
  • However, the inhibition of the survivin pathway by the combined treatment with IR and bortezomib, observed in the present study, revealed a novel aspect in the tumor biology of chondrosarcoma 3D spheroid cultures and may represent a potential target for therapy. (spandidos-publications.com)
  • One of the most common types of bone cancer in adults, chondrosarcoma is a malignant tumor made up of cartilage-producing cells. (uabmedicine.org)
  • Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma. (semanticscholar.org)
  • Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy. (biomedcentral.com)
  • We documented changes in gene expression that accompany changes in tumor phenotype, and these gene expression changes provide insight into the pathways that may play a role in the development and progression of chondrosarcoma. (biomedcentral.com)
  • Chondrosarcoma is a common primary malignant tumor of the bone that can metastasize through the vascular system to other organs. (ovid.com)
  • Overexpression of resistin in chondrosarcoma cells significantly enhanced VEGF-C production and LECs-associated lymphangiogenesis in vitro and tumor-related lymphangiogenesis in vivo. (ovid.com)
  • We suggest that resistin may represent a molecular target in VEGF-C-associated tumor lymphangiogenesis in chondrosarcoma metastasis. (ovid.com)
  • Chondrosarcoma is a malignant cartilage forming bone tumor, in which mutations altering isocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) activity have been identified as potential driver mutations. (aacrjournals.org)
  • The far most prevalent subtype (72% of the cases) is conventional central chondrosarcoma, in which the tumor arises centrally in the medulla of the bone. (aacrjournals.org)
  • This subtype can be histologically subdivided into atypical cartilaginous tumor (ACT), grade II and grade III chondrosarcomas. (aacrjournals.org)
  • Chondrosarcoma patients with unresectable disease, due to tumor location, tumor size, or extensive metastatic disease, have a 5-year survival of only 2% as the overall efficacy of chemotherapy is limited ( 8, 9 ). (aacrjournals.org)
  • In this study, we showed a clinical correlation between adiponectin and VEGF-C as well as tumor stage in human chondrosarcoma tissues. (clinsci.org)
  • Loss of DNA methylation was accompanied by an increase in invasiveness of the rat chondrosarcoma cells, in vitro, as well as by an increase in tumor growth in vivo. (luriechildrens.org)
  • S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. (aacrjournals.org)
  • In vivo anti-tumor activity of BEZ235, a phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor, was evaluated in a chondrosarcoma xenograft model. (aacrjournals.org)
  • Tumor growth was similarly inhibited in a xenograft model of chondrosarcoma. (aacrjournals.org)
  • Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation -- Martin et al. (aacrjournals.org)
  • Although chondrosarcomas are better known for their involvement of the pelvis and extremities, they are the most common malignant tumor of the chest wall [5] . (cureus.com)
  • Dedifferentiated chondrosarcoma and high-grade chondrosarcoma are most likely to spread (metastasize) to other areas. (massgeneral.org)
  • Recent studies have shown that induction of apoptosis in high-grade chondrosarcoma, both directly and by enhancement of response to chemotherapy and radiation, is a valid therapeutic strategy. (wikipedia.org)
  • Galoian K, Temple TH, Galoyan A. Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma. (springer.com)
  • however, the survival of high-grade chondrosarcoma patients is still poor after surgical therapy. (nature.com)
  • The lesions were divided into four histological grades: atypical enchondroma (grade 0), low-grade chondrosarcoma (grade I), intermediate grade chondrosarcoma (grade II), and high-grade chondrosarcoma (grade III). (scielo.org.za)
  • Final diagnosis: high-grade chondrosarcoma . (radiopaedia.org)
  • Background: Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very important because the treatment strategies for these diseases are completely different. (ebscohost.com)
  • As the name implies, cells biopsied from this type of chondrosarcoma appear clear with many large vacuoles. (encyclopedia.com)
  • Myxoid chondrosarcoma is a type of chondrosarcoma. (wikipedia.org)
  • A dedifferentiated chondrosarcoma tumour is treated like an osteosarcoma tumour because it is a more aggressive type of chondrosarcoma. (cancer.ca)
  • Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. (cancer.ca)
  • However, one rare type of chondrosarcoma develops in the soft tissues, such as the muscles, nerves, or fat, of the arms and legs. (harvard.edu)
  • A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. (linkedlifedata.com)
  • The use of chemotherapy may depend on the type of chondrosarcoma that you have. (coliseumhealthsystem.com)
  • ABSTRACT: Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. (scirp.org)
  • Dedifferentiated chondrosarcoma may be treated with some of the same chemotherapy drugs that are used for osteosarcoma . (cancer.ca)
  • The non-cartilaginous component of dedifferentiated chondrosarcoma is generally an osteosarcoma , a fibrosarcoma, or a malignant fibrous histiocytoma. (atlasgeneticsoncology.org)
  • major challenges are the distinction between grade I chondrosarcomas and chondromas, and the differential diagnosis with chondroblastic osteosarcoma and chondroid chordoma. (nih.gov)
  • Is chondrosarcoma as fast growing as osteosarcoma? (artofphotographyshow.com)
  • Rare primary bone malignancies such as clear cell chondrosarcoma and giant cell rich osteosarcoma can also mimic GCTB but often have more destructive features, adjacent bone marrow edema, and/or a soft tissue mass component. (thefreedictionary.com)
  • However, compared to osteosarcoma, chondrosarcoma is uncommon. (tripawds.com)
  • Like osteosarcoma, chondrosarcoma is a metastatic disease that spreads. (tripawds.com)
  • There are 4 cases of canine primary osteosarcoma and 5 chondrosarcomas in the COPLOW collection. (arvojournals.org)
  • Lytic lesions may be detected by cortical perforation and possible extension, which can result in a large mass. 4 Due to its locally invasive nature, high rates of recurrence, and metastatic seeding of the skeleton and lungs, dedifferentiated chondrosarcoma carries a grave prognosis. (appliedradiology.com)
  • Purpose of review: The prognosis of patients with unresectable or metastatic chondrosarcoma of the bone is poor. (medworm.com)
  • Dedifferentiated chondrosarcoma accounts for approximately 10% of all chondrosarcomas and shows an increased growth rate and rapid metastatic spread in comparison with ordinary chondrosarcomas. (atlasgeneticsoncology.org)
  • Histologically 46 tumours were low-grade (grade 0 or I) chondrosarcoma (82%), there were nine cases of intermediate (grade II) chondrosarcoma (16%), and one patient had a metastatic mesenchymal chondrosarcoma. (scielo.org.za)
  • Two patients died, one with metastatic mesenchymal chondrosarcoma involving the scapula, and the other with an intermediate (grade 2) lesion of the pelvis. (scielo.org.za)
  • Grade 1 chondrosarcomas have little or no metastatic potential and are often difficult to distinguish from painful benign enchondromas. (ebscohost.com)
  • A key step in the metastatic process, lymphangiogenesis, involves vascular endothelial growth factor-C (VEGF-C). However, the effects of lymphangiogenesis in chondrosarcoma metastasis remain to be clarified. (ovid.com)
  • Chemotherapy has not been shown to be effective when treating chondrosarcoma in dogs. (vetinfo.com)
  • Chemotherapy is not used for low-grade chondrosarcoma because it has not been shown to help improve survival. (cancer.ca)
  • Chondrosarcomas are in general resistant to chemotherapy and radiotherapy. (medworm.com)
  • Due to its poor response to both radiotherapy and chemotherapy, the management of chondrosarcoma faces a complicated challenge 2 . (nature.com)
  • Dr. Chretin states that there haven't been any good, large scale studies done on dogs with chondrosarcoma who were treated with chemotherapy. (tripawds.com)
  • Chondrosarcomas represent a heterogeneous group of primary bone cancers that are characterized by hyaline cartilaginous neoplastic tissue and are predominantly resistant to radiation and chemotherapy. (spandidos-publications.com)
  • Because of their hypovascularity and slow mitotic activity, conventional chondrosarcomas are distinguished for their resistance to chemotherapy and radiation therapy [3] . (cureus.com)
  • Follow up scans are extremely important for chondrosarcoma to make sure there has been no recurrence or metastasis, which usually occurs in the lungs. (wikipedia.org)
  • Not one patient with low-grade chondrosarcoma treated adequately with local curettage and surgical adjuvant therapy presented with local recurrence or distal metastasis. (scielo.org.za)
  • Furthermore, specific functional analysis indicates that thymosin-β4 may have a role in chondrosarcoma metastasis. (biomedcentral.com)
  • Two other subtypes with a worse prognosis are dedifferentiated chondrosarcoma, a highly malignant variant ( 4 ), and mesenchymal chondrosarcoma, a rare aggressive subtype in which distant metastasis can be identified even after 20 years ( 5-7 ). (aacrjournals.org)
  • Chondrosarcoma is the second most frequently occurring type of bone malignancy that is characterized by the distant metastasis propensity. (clinsci.org)
  • Thus, adiponectin could serve as a therapeutic target in chondrosarcoma metastasis and lymphangiogenesis. (clinsci.org)
  • The phosphorylation of sphingosine by sphingosine kinase enzymes SphK1 and SphK2 generates sphingosine-1-phosphate (S1P), which inhibits human chondrosarcoma cell migration, while SphK1 overexpression suppresses lung metastasis of chondrosarcoma. (aging-us.com)
  • There are three variant chondrosarcomas: clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. (encyclopedia.com)
  • Clear cell chondrosarcoma is the most rare form of chondrosarcoma. (encyclopedia.com)
  • However, as opposed to clear cell chondrosarcoma, it is highly malignant and frequently metastasizes, commonly to the lungs, lymph nodes and other bones. (encyclopedia.com)
  • Clear cell chondrosarcoma and intermediate or middle grade chondrosarcomas are less likely to spread to other areas. (massgeneral.org)
  • Clear cell chondrosarcoma of bone: a report of 8 cases. (thefreedictionary.com)
  • Clear cell chondrosarcoma is an extremely rare malignant neoplasm. (bmj.com)
  • Chordoma and chondrosarcoma arising in the skull base will be reviewed here. (uptodate.com)
  • Histologically proven chordoma or chondrosarcoma. (knowcancer.com)
  • We read with great interest the recent article entitled "Diffusion-Weighted MRI: Distinction of Skull Base Chordoma from Chondrosarcoma" by Yeom et al. (ajnr.org)
  • We have now replicated these findings with a sample of 14 chordoma and 10 chondrosarcoma cases from our own institution. (ajnr.org)
  • Overall, nasal and paranasal sinus chondrosarcomas are very aggressive and carry a guarded prognosis. (petplace.com)
  • This review discusses recent developments in the characterization of molecular pathways involved in the oncogenesis of chondrosarcoma that should be explored to improve prognosis of patients with advanced chondrosarcoma. (medworm.com)
  • Summary: As many different genetic alterations in chondrosarcoma have been identified, it is of the utmost importance to classify druggable targets that may improve the prognosis of chondrosarcoma patients. (medworm.com)
  • Therapeutic intervention studies of these new targets emerging from preclinical studies are of highest importance to improve prognosis of chondrosarcoma patients with advanced disease. (medworm.com)
  • Prognosis - The reported median survival of dogs with nasal chondrosarcoma has been found to be 210 days to 580 days with various treatments like radiation therapy, rhinotomy (incision made into the nose to drain accumulated pus) and radiation therapy combined and rhinotomy alone. (wearethecure.org)
  • Chondrosarcomas frequently recur and, thus, follow up scans are vital to a good long-term prognosis. (knowcancer.com)
  • Chordomas have a significantly worse prognosis than chondrosarcomas, with 5-year progression-free survival estimated at 80% for chondrosarcomas but only 40% for chordomas. (ajnr.org)
  • Benign cartilage lesions can be difficult to differentiate from slow-growing, low-grade chondrosarcomas. (medscape.com)
  • Secondary chondrosarcoma can occur in a previously benign cartilaginous lesion. (medscape.com)
  • Some varieties of chondrosarcoma arise from the transformation of benign cartilage lesions into cancers. (mayoclinic.org)
  • Most chondrosarcomas are low grade, but dedifferentiated chondrosarcoma can occur in the setting of a longstanding benign cartilage lesion such as enchondroma. (bonetumor.org)
  • It may have focal calcification, mucoid I degeneration, or necrosis.Histologically, chondrosarcoma is differentiated from benign cartilage growths by enlarged plump nuclei, multiple cells per lacunae, binucleated cells, and hyperchromic nuclear pleomorphism. (bonetumor.org)
  • Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (linkedlifedata.com)
  • It is possible that low-grade chondrosarcoma may have a far more benign course than other chondrosarcomas and, if treated adequately, may require a far less vigorous follow-up regimen. (scielo.org.za)
  • Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. (mdpi.com)
  • Report Highlights Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Chondrosarcoma - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Chondrosarcoma (Oncology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (medindia.net)
  • GlobalData's clinical trial report, "Chondrosarcoma Global Clinical Trials Review, H1, 2017" provides an overview of Chondrosarcoma clinical trials scenario. (sandlerresearch.org)
  • Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. (wikipedia.org)
  • Chondrosarcoma is a type of bone cancer that develops in cartilage cells. (hopkinsmedicine.org)
  • Chondrosarcoma is the second most common type of primary bone cancer. (hopkinsmedicine.org)
  • Chondrosarcoma is the second most common bone cancer in dogs. (vetinfo.com)
  • The article titled "Intramedullary Chondrosarcoma of Proximal Humerus" [ 1 ] has been retracted as it was found to contain a substantial amount of material, without referencing, from the following published article: "Review: Imaging of Chondrosarcomas," by L. Ollivier, D. Vanel, and J. Leclère, in Cancer Imaging. (hindawi.com)
  • Chondrosarcoma is a rare type of cancer that usually begins in the bones, but can sometimes occur in the soft tissue near bones. (mayoclinic.org)
  • Chondrosarcoma is a type of cancer closely related to bone cancer. (harvard.edu)
  • Treatment - Chondrosarcoma is amenable to surgery because a reliable adjuvant chemotherapeutic agent does not exist for this type of cancer. (wearethecure.org)
  • Chondrosarcoma is a cartilaginous cancer (a cartilage-based bone cancer) that represents approximately 25% of all primary bone cancer cases. (knowcancer.com)
  • Chondrosarcoma (CSA) of the bone is a fast spreading and malignant form of cancer, which, if not diagnosed and treated early, can be life threatening. (artofphotographyshow.com)
  • Interview about chondrosarcoma bone cancer in dogs with information and treatment options as shared by Dr. Johnny Chretin of VCA West Los Angeles Animal Specialty Oncology Clinic. (tripawds.com)
  • One dog's story about symptoms and diagnosis of canine chondrosarcoma bone cancer in the spine. (tripawds.com)
  • Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. (nyhq.org)
  • Chondrosarcoma is the second most common type of primary bone cancer in adults. (brighamandwomens.org)
  • However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. (mdpi.com)
  • Chondrosarcoma is commonly a primary cancer, meaning it originates in the bone, rather than spreading from another organ. (uabmedicine.org)
  • Surgery is the main treatment for most types of chondrosarcoma. (cancer.ca)
  • There are three additional types of chondrosarcoma. (bonetumor.org)
  • However, the median survival time of dogs with chondrosarcoma of the ribs varies largely. (wearethecure.org)
  • Medical records were retrospectively reviewed to identify dogs with chondrosarcoma of bone in potentially surgically accessible sites. (artofphotographyshow.com)
  • Dogs with chondrosarcoma of the skull have life expectancy between 210 and 580 days - in our case it was 180 days - after the first alterations on the eye of the dog occurred. (artofphotographyshow.com)
  • Treatment for chondrosarcoma is almost entirely surgical. (massgeneral.org)
  • citation needed] Surgery is the main form of treatment for chondrosarcoma. (wikipedia.org)
  • The dog's condition is an important factor when determining the course of treatment for chondrosarcoma. (vetinfo.com)
  • Winn HR. Chordomas and chondrosarcomas. (mayoclinic.org)
  • Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. (elsevier.com)
  • This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. (elsevier.com)
  • Adjuvant radiation is recommended for chordomas and chondrosarcomas, as opposed to delayed radiation initiated at recurrence. (oncolink.org)
  • PBT immediately following surgery is favorable in patients with clival chordomas and chondrosarcomas in comparison to PBT at the time of recurrence. (oncolink.org)
  • Stereotactic radiosurgery is an important option for skull base chordomas and chondrosarcomas either as primary or adjunctive treatment. (thejns.org)
  • A small minority of secondary chondrosarcomas occur in patients with Maffucci syndrome and Ollier disease. (wikipedia.org)
  • Chondrosarcoma (primary, secondary, dedifferentiated and clear cell). (mayoclinic.org)
  • Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma. (uptodate.com)
  • There was a stalk that had a radiographic appearance consistent with a secondary chondrosarcoma. (aaos.org)
  • Central chondrosarcoma is most common 1,3 and may be secondary to an enchondroma. (sarcomahelp.org)
  • Approximately 15% 3 of chondrosarcomas (secondary (peripheral) chondrosarcoma) are located at the surface of bone and result from malignant transformation of osteochondroma. (sarcomahelp.org)
  • Resveratrol significantly decreased cell viability and induced cell apoptosis in human chondrosarcoma cells in a dose-dependent manner. (nature.com)
  • Central chondrosarcomas may be low, medium or high grade. (massgeneral.org)
  • The rate of dedifferentiation is 13%-15% in central chondrosarcomas compared to 4%-5% in peripheral chondrosarcomas. (atlasgeneticsoncology.org)
  • Functional NRAS mutations were found in 12% of conventional central chondrosarcomas. (aacrjournals.org)
  • Chondrosarcoma primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, or knee. (hopkinsmedicine.org)
  • Chondrosarcoma usually affects the ribs, nasal bones and pelvis. (vetinfo.com)
  • It is used to treat a chondrosarcoma in the bones of the skull or spine, as well as in the arm, leg and pelvis. (cancer.ca)
  • Limb-sparing surgery may be used to treat chondrosarcoma in the arm, leg and pelvis. (cancer.ca)
  • Chondrosarcoma is considered as a common primary bone sarcoma, which is ranked as the third primary bone malignancy One in five cases of bone sarcomas are due to chondrosarcoma , and half of all cases affect the pelvis (1). (thefreedictionary.com)
  • Little has been published about the outcome of patients with recurrent chondrosarcoma of the pelvis. (semanticscholar.org)
  • Survival analysis of patients with chondrosarcomas of the pelvis. (semanticscholar.org)
  • Chondrosarcomas frequently affect the pelvis and upper and lower extremities. (cureus.com)
  • Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
  • Mesenchymal chondrosarcoma is a rare variant with a bimorphic histologic picture of low grade cartilaginous cells and hypercellular small, uniform, and undifferentiated cells that resemble Ewing's sarcoma. (bonetumor.org)
  • RT-PCR or FISH evidence of this HEY1-NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas. (nih.gov)
  • Chondrosarcoma patients, especially those of high histologic grade with lower expression and hypermethylation of NAPRT, may benefit from inhibition of the NAD synthesis pathway. (aacrjournals.org)
  • It is characterized by the presence of a mix of low-grade chondrosarcoma and has undergone malignant degeneration, producing a fully malignant soft tissue mass that is no longer identifiable as cartilage. (encyclopedia.com)
  • It may be used after curettage to treat some small, low-grade chondrosarcoma tumours. (cancer.ca)
  • original magnification, 10x) shows abrupt transition between a low grade chondrosarcoma (left) and a high grade spindle cell sarcoma (right). (atlasgeneticsoncology.org)
  • Others advocate that dedifferentiation is the result of two differing clones of cells, one of which differentiates into a low-grade chondrosarcoma, while the other fails to differentiate and displays features of a high-grade sarcoma. (atlasgeneticsoncology.org)
  • Treatment for low grade chondrosarcoma may include curettage or marginal excision. (bonetumor.org)
  • Low grade chondrosarcoma is very close in appearance to enchondromas and osteochondromas and has occasional binucleated cells. (bonetumor.org)
  • Biopsy of the solid lesion demonstrated a low-grade chondrosarcoma, while no tissue sample of the cystic lesion could be retrieved. (frontiersin.org)
  • Sagittal, contrast-enhanced T1-weighted MR-image showing a mass (7 × 8 × 15 mm, height x depth x width) with peripheral contrast-uptake that was later identified as a low-grade chondrosarcoma. (frontiersin.org)
  • Low grade chondrosarcoma: is long-term follow-up necessary? (scielo.org.za)
  • Currently, the follow-up regimen for patients treated for low-grade chondrosarcoma is similar to that of all chondrosarcomas. (scielo.org.za)
  • This appears to be adequate for timely detection and treatment of any local recurrence of low-grade chondrosarcoma. (scielo.org.za)
  • These are all characteristics of a low-grade chondrosarcoma. (biomedsearch.com)
  • Lightenstein and Bernstein first described mesenchymal chondrosarcomas in 1959, and Dowling reported the first case of an extraskeletal mesenchymal chondrosarcoma in 1964. (hcplive.com)
  • Extraskeletal mesenchymal chondrosarcomas involve muscles or the central nervous system. (hcplive.com)
  • The novel HEY1-NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas. (nih.gov)
  • It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal chondrosarcomas, particularly those with less than optimal pathologic features or sampling. (springer.com)
  • Mesenchymal chondrosarcomas constitute about 5% of all chondrosarcomas. (dovemed.com)
  • The grade of chondrosarcoma, outcome and tumour recurrence was evaluated in these patients. (scielo.org.za)
  • We believe that adequately treated low-grade chondrosarcomas have a very low local recurrence rate. (scielo.org.za)
  • 18F-FDG PET/CT in Diagnostic and Prognostic Evaluation of Patients With Suspected Recurrence of Chondrosarcoma. (semanticscholar.org)
  • Oncologic outcome after local recurrence of chondrosarcoma: Analysis of prognostic factors. (semanticscholar.org)
  • Dedifferentiated chondrosarcoma is an aggressive subtype of chondrosarcoma that is characterized by a cartilaginous component and a highly lytic sarcomatous component. (appliedradiology.com)
  • It is a subtype of chondrosarcoma, a term that includes a heterogeneous group of lesions with varied clinical behaviour and morphological features that share the common feature arising from ossified cartilage or cartilaginous rests. (scielo.org.za)
  • Microscopic evaluation revealed a biomorphic pattern composed of undifferentiated round or oval cells resembling embryonal mesenchyme and well-differentiated cartilaginous tissue, which is a characteristic finding of extraskeletal mesenchymal chondrosarcoma (Figure 4). (hcplive.com)
  • Chondrosarcomas are heterogeneous, mostly slow-growing, primary malignancies of the bone that are characterized by hyaline cartilaginous neoplastic tissue formation ( 1 , 2 ). (spandidos-publications.com)
  • Intracranial chondrosarcomas are cartilaginous tumours that are extremely rare with an estimated incidence of less than 0.16% of all intracranial neoplasms. (minervamedica.it)
  • Seventy-six percent of primary chondrosarcomas occur centrally within a bone. (encyclopedia.com)
  • Although there are exceptions, chondrosarcomas occur mainly in older adults forty to sixty years old and typically occur more in men than in women. (encyclopedia.com)
  • While chondrosarcoma can occur at any age, the most prevalent variety typically affects middle-aged to older adults. (mayoclinic.org)
  • Chondrosarcomas most often occur in males. (thefreedictionary.com)
  • Chondrosarcoma can occur at any age but is more common in people older than 40 years. (linkedlifedata.com)
  • These results indicate, in agreement with our previous kinetic data, that the major part of the xylosyl transfer to the chondrosarcoma proteoglycan core protein precursor must occur late in the processing sequence, i.e. after about 85% of its intracellular lifetime and no more than 7 min before the addition of the rest of the chondroitin sulfate chain. (lu.se)
  • These lesions sometimes transform into chondrosarcoma. (mayoclinic.org)
  • For such cystic lesions in combination with chondrosarcoma, a treatment course with steroids should be considered along with surgical exploration necessary to obtain the diagnosis and for potential reduction of mass-effect on the medulla oblongata. (frontiersin.org)
  • One such tumour, the chondrosarcoma, the most malignant cartilage tumour, represents 0.15% of all cranial space occupying lesions and 6% of all skull base tumours. (bmj.com)
  • Objective: To assess if diffusion-weighted MRI (DWI) can differentiate between central enchondromas and chondrosarcomas (CS) and if DWI can distinguish low-grade chondroid lesions from high-grade CS. (ebscohost.com)
  • Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. (thejns.org)
  • Špero M. (2018) Neurinoma: Chondrosarcoma of the Thoracic Spine. (springer.com)
  • Patients with Ollier's disease (multiple enchondromatosis) or Maffucci's syndrome (multiple enchondromas and hemangiomas) are at much higher risk of chondrosarcoma than the normal population and often present in the third and fourth decade. (bonetumor.org)
  • There is a risk of ~35% that the enchondromas turn into malignant chondrosarcomas. (sarcomahelp.org)
  • To examine its effect on tumorigenesis, we induced DNA demethylation in a rat model of human chondrosarcoma using 5-aza-2-deoxycytidine. (luriechildrens.org)
  • Using a three‑dimensional (3D) spheroid model, 0‑20 Gy of IR was applied to chondrosarcoma cells and healthy human chondrocytes. (spandidos-publications.com)
  • Small interfering RNA or small molecule inhibitors against RTKs or downstream signaling proteins were applied to chondrosarcoma cells and changes in biochemical signaling, cell cycle, and cell viability were determined. (aacrjournals.org)
  • Patients with adequately resected low grade chondrosarcomas have an excellent survival rate. (bonetumor.org)
  • Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. (nih.gov)
  • Unlike other primary bone sarcomas that mainly affect children and adolescents, a chondrosarcoma can present at any age. (wikipedia.org)
  • Lloret I et al (2006) Primary spinal chondrosarcoma: radiologic findings with pathological correlation. (springer.com)
  • A case of primary chondrosarcoma of the lung is described in a 64-year-old man. (bmj.com)
  • When a primary chondrosarcoma originates within a bone organ (organs of the skeletal system) it is called central or medullary chondrosarcoma but when it develops in the periosteum (membrane lining the outer surface of all bones) it is known as peripheral chondrosarcoma. (wearethecure.org)
  • Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. (biomedsearch.com)
  • To describe a case series of primary ocular osteosarcomas and chondrosarcomas in dogs. (arvojournals.org)
  • The COPLOW database was mined for cases of primary osteosarcomas and chondrosarcomas. (arvojournals.org)
  • Canine primary osteosarcomas and chondrosarcomas frequently present with hyphema, uveitis, and increased intraocular pressure in older dogs. (arvojournals.org)
  • Among the less common are chondrosarcoma, fibrosarcoma , and malignant fibrous histiocytoma , all of which arise from spindle cell neoplasms. (encyclopedia.com)
  • Extraskeletal chondrosarcomas are mesenchymal neoplasms of soft tissues and visceral organs that produce neoplastic chondrocytes in a fibrillary matrix. (artofphotographyshow.com)
  • On plain radiographs, chondrosarcoma of the long bones is a fusiform, lucent defect with scalloping of the inner cortex and periosteal reaction. (bonetumor.org)
  • Khalil S, Al-Rahawan MG, Al-Rahawan MM. Periosteal mesenchymal chondrosarcoma of the tibia. (springer.com)
  • The nasal cavity on the other hand is also highly susceptible to developing chondrosarcoma. (wearethecure.org)
  • Nasal chondrosarcoma may metastasize to adjacent sinuses or invade overlying bone and penetrate adjacent soft tissues. (wearethecure.org)
  • In case of nasal chondrosarcoma, the signs may include sneezing, unilateral and sometimes bilateral purulent (pus), bloody discharge and nasal obstruction followed with bone destruction. (wearethecure.org)
  • These results suggest that resveratrol induces chondrosarcoma cell apoptosis via a SIRT1-activated NF-κB deacetylation and exhibits anti-chondrosarcoma activity in vivo . (nature.com)
  • The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. (clinicaltrials.gov)
  • These specific alterations can be employed for use in clinical interventions in advanced chondrosarcoma. (medworm.com)
  • Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study. (artofphotographyshow.com)
  • The available data in the literature (177 cases), two current clinical patients, and cases which occurred in The Netherlands (13) were reviewed concerning the clinical presentation, pathological features, radiological data, and treatment options of chondrosarcoma of the cranial base. (bmj.com)
  • UAB is an active participant in research and clinical trials for the diagnosis and treatment of chondrosarcoma. (uabmedicine.org)
  • This report provides top line data relating to the clinical trials on Chondrosarcoma. (sandlerresearch.org)
  • Resistin levels were positively correlated with VEGF-C-dependent lymphangiogenesis via the down-regulation of miR-186 expression in clinical samples from chondrosarcoma tissue. (ovid.com)
  • What are the Clinical Indications for performing the Molecular Testing for Mesenchymal Chondrosarcoma Test? (dovemed.com)
  • These were biopsy-proven dedifferentiated chondrosarcoma (Figure 3). (appliedradiology.com)
  • Fine-needle aspiration of the mass (Figure 5) and subsequent biopsy (Figure 6) resulted in the pathologic diagnosis of dedifferentiated chondrosarcoma. (appliedradiology.com)
  • In many chondrosarcoma cases, the tissue can be extracted with a needle, but if the chondrosarcoma is located centrally in the body, then the biopsy necessitates surgery. (knowcancer.com)
  • Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. (bmj.com)
  • The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.The Chondrosarcoma (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Chondrosarcoma and features dormant and discontinued projects. (medindia.net)
  • Similarly, the Universities portfolio in Phase I stages comprises 1 molecules, respectively.Chondrosarcoma (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (medindia.net)
  • Scope - The pipeline guide provides a snapshot of the global therapeutic landscape of Chondrosarcoma (Oncology). (medindia.net)
  • The pipeline guide reviews pipeline therapeutics for Chondrosarcoma (Oncology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (medindia.net)
  • The pipeline guide reviews key companies involved in Chondrosarcoma (Oncology) therapeutics and enlists all their major and minor projects. (medindia.net)
  • The pipeline guide evaluates Chondrosarcoma (Oncology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (medindia.net)
  • The pipeline guide reviews latest news related to pipeline therapeutics for Chondrosarcoma (Oncology) Reasons to buy - Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies. (medindia.net)
  • Find and recognize significant and varied types of therapeutics under development for Chondrosarcoma (Oncology). (medindia.net)
  • Formulate corrective measures for pipeline projects by understanding Chondrosarcoma (Oncology) pipeline depth and focus of Indication therapeutics. (medindia.net)
  • During our visit with Dr. Johnny Chretin , head of oncology at VCA Animal Hospital West Los Angeles Oncology Center , we wanted to know a little more about chondrosarcoma in dogs. (tripawds.com)
  • Dedifferentiated chondrosarcoma occurs in approximately 11% of patients diagnosed with chondrosarcoma and is considered to be a histological subtype of this chondroid lesion. (appliedradiology.com)
  • Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events. (lu.se)
  • The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. (nih.gov)
  • The NR4A3 nuclear receptor is implicated in the development of extraskeletal myxoid chondrosarcoma (EMC), primitive sarcoma unrelated to conventional chondrosarcomas, through a specific fusion with EWSR1 resulting in an aberrant fusion protein that is thought to disrupt the transcriptional regulation of specific target genes. (nih.gov)
  • Extraskeletal myxoid chondrosarcoma is a rare soft tissue sarcoma. (pubmedcentralcanada.ca)
  • Here we report the case of a 15-year-old girl who presented with extraskeletal myxoid chondrosarcoma in the sacrococcygeal region which was regarded as unresectable. (pubmedcentralcanada.ca)
  • Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. (encyclopedia.com)
  • Central chondrosarcoma occurs within a bone, and peripheral chondrosarcoma develops on the surface of a bone. (encyclopedia.com)
  • Peripheral chondrosarcoma (PCS) remains a malignancy for which no treatments other than radical surgery have proven effective. (curesarcoma.org)
  • We now report the first mouse genetic model of peripheral chondrosarcoma, which is completely penetrant. (curesarcoma.org)
  • Although peripheral chondrosarcoma is far less common, many of the active signalling pathways in chondrosarcoma have been identified after the initial genetic event was elucidated. (sarcomahelp.org)
  • We expected that we could further unravel the initiating event for enchondroma and central chondrosarcoma by studying Ollier disease as a model, similar to Multiple Osteochondromas elucidating many of the pathways involved in peripheral chondrosarcoma (Table 1). (sarcomahelp.org)
  • Chondrosarcomas arise from chondroblasts, cells that form cartilage. (encyclopedia.com)
  • Most often, chondrosarcoma happens from normal cartilage cells. (hopkinsmedicine.org)
  • The defining characteristic of a chondrosarcoma is that its cells produce cartilage. (mayoclinic.org)
  • 1 The term "dedifferentiated" implies that a portion of cells from the chondrosarcoma have degenerated into a high-grade malignant form that is characterized by pleomorphism, anaplasia, hypercellularity, and increased mitoses. (appliedradiology.com)
  • There is no report about the role of SIRT1 in the human chondrosarcoma cells. (nature.com)
  • Both siRNA-SIRT1 transfection and MS-275 significantly inhibited the resveratrol-induced caspase-3 cleavage and activity in human chondrosarcoma cells. (nature.com)
  • One possible explanation is that chondrosarcoma cells have lost their sense of direction. (curesarcoma.org)
  • Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and "Chinese letter" shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia. (dovepress.com)
  • Most often, chondrosarcoma starts in normal cartilage cells. (brighamandwomens.org)
  • In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. (mdpi.com)
  • The presence of CD99 positive spindle cells suggests mesenchymal chondrosarcoma . (radiopaedia.org)
  • However, the amount of these spindled cells is small and not all the classic features of mesenchymal chondrosarcoma are seen on histology. (radiopaedia.org)
  • By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. (lu.se)
  • Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. (lu.se)
  • the chondrosarcoma cells demonstrated a significant dose‑dependent increase in the expression levels of the DNA damage marker histone H2AX phosphorylation at serine 139 (γH2AX). (spandidos-publications.com)
  • Comparative analyses of γH2AX at 1 and 24 h post‑IR revealed efficient DNA repair in human chondrosarcoma cells. (spandidos-publications.com)
  • Therefore, additional bortezomib treatment may only temporarily improve the radiation sensitivity of chondrosarcoma cells. (spandidos-publications.com)
  • In this study, we demonstrate that resistin enhances VEGF-C expression and lymphatic endothelial cells (LECs)-associated lymphangiogenesis in human chondrosarcoma cells. (ovid.com)
  • The expression level of NAMPT and NAPRT transcripts in chondrosarcoma cells was determined by qRT-PCR. (aacrjournals.org)
  • Chondrosarcoma cells showed a dose-dependent decrease in cell viability, 3D collagen invasion, and colony formation upon treatment with NAMPT inhibitors, in which nearly half of the cell lines demonstrated absolute IC 50 s in the low nanomolar range. (aacrjournals.org)
  • We further demonstrated that adiponectin promoted VEGF-C expression and secretion in human chondrosarcoma cells. (clinsci.org)
  • Following withdrawal of 5-aza-2-deoxycytidine, the rat chondrosarcoma cells reestablished global DNA methylation levels that were comparable to that of control cells. (luriechildrens.org)
  • Concurrently, invasiveness of the rat chondrosarcoma cells, in vitro, decreased to a level indistinguishable to that of control cells. (luriechildrens.org)
  • Taken together these experiments demonstrate that global DNA hypomethylation induced by 5-aza-2-deoxycytidine may promote specific aspects of tumorigenesis in rat chondrosarcoma cells. (luriechildrens.org)
  • In addition, chondrosarcoma cells with an NRAS mutation were sensitive to treatment with a MEK inhibitor. (aacrjournals.org)
  • Morphological changes during serial subculture of chondrosarcoma cells. (aacrjournals.org)
  • Surprisingly, our investigations found that treatment of chondrosarcoma cells with S1P and transfecting them with SphK1 cDNA increased PDGF-A expression and induced angiogenesis of endothelial progenitor cells (EPCs). (aging-us.com)
  • What are the risk factors for chondrosarcoma? (hopkinsmedicine.org)
  • Talk with your healthcare provider about your risk factors for chondrosarcoma and what you can do about them. (brighamandwomens.org)
  • Conformal proton beam radiation therapy or intensity-modulated radiation therapy (IMRT) may be used for chondrosarcoma tumours found at the base of the skull or in the spinal bones (vertebrae). (cancer.ca)
  • Radiographic findings of 15 untreated chondrosarcomas of the cranial and facial bones were reviewed. (ajnr.org)
  • Molecular Testing for Mesenchymal Chondrosarcoma is a genetic test that is helpful in aiding a diagnosis of mesenchymal chondrosarcoma. (dovemed.com)
  • 1 The authors showed, with a sample of 19 patients, that skull base chondrosarcomas could be differentiated from chordomas and from atypical chordomas by ADC values on diffusion-weighted MR imaging. (ajnr.org)
  • Treatment of chondrosarcoma in dogs must be aggressive. (vetinfo.com)
  • Being aggressive and malignant in nature, chondrosarcomas of the larynx and trachea are usually life-threatening. (petmd.com)
  • In type 1, the radiographic appearance is the same as for a central chondrosarcoma, with the addition of a region with very aggressive bone destruction. (atlasgeneticsoncology.org)
  • Strike SA, McCarthy EF (2011) Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. (springer.com)
  • In cases where the chondrosarcoma affects the skull, spine, or chest cavity, a neurosurgeon or a thoracic surgeon usually performs the operation. (knowcancer.com)
  • Mesenchymal chondrosarcoma has a predilection for the spine, ribs and jaw and it presents in the third decade. (bonetumor.org)
  • However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the ends of bones and lines joints, not in the bone tissue itself. (harvard.edu)
  • Chondrosarcoma of the vertebrae leads to compression of the nervous tissue but there are no visible signs. (wearethecure.org)
  • Dedifferentiated chondrosarcoma: Radiographic features. (appliedradiology.com)
  • Three radiographic types of dedifferentiated chondrosarcoma have been described. (atlasgeneticsoncology.org)
  • Radiographic assessment of chondrosarcomas includes plain radiography of the entire bone involved. (cureus.com)
  • Chondrosarcomas have been observed as a late consequence of radiation therapy for other cancers. (hopkinsmedicine.org)
  • External beam radiation therapy may be used to treat chondrosarcoma that can't be removed with surgery. (cancer.ca)
  • Radiation therapy is also used for recurrent chondrosarcoma. (cancer.ca)
  • Chondrosarcomas can be caused by radiation therapy used to treat other cancers. (brighamandwomens.org)