Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Chondrosarcoma, Mesenchymal
A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)
Chondroma
Chordoma
Myxosarcoma
Cartilage
Skull Base Neoplasms
Exostoses, Multiple Hereditary
Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
Neoplasms, Connective and Soft Tissue
Osteosarcoma
Ribs
Pelvic Bones
Chondroitinases and Chondroitin Lyases
Chondromatosis, Synovial
Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.
Osteochondroma
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
Cartilage, Articular
Canada
American Cancer Society
Joint Loose Bodies
Access to Information
Cranial Fossa, Middle
The compartment containing the anterior extremities and half the inferior surface of the temporal lobes (TEMPORAL LOBE) of the cerebral hemispheres. Lying posterior and inferior to the anterior cranial fossa (CRANIAL FOSSA, ANTERIOR), it is formed by part of the TEMPORAL BONE and SPHENOID BONE. It is separated from the posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) by crests formed by the superior borders of the petrous parts of the temporal bones.
Encyclopedias as Topic
Dictionaries as Topic
Skull Base
Neuronavigation
Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.
Laryngeal Neoplasms
Larynx
Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD). (1/542)
Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short times after injection of photosensitizer. Groups of rats with chondrosarcoma were given 2 mg kg(-1) of BPD intravenously 5 min to 180 min before light treatment of 150 J cm(-2) 690 nm. Vascular response was monitored using intravital microscopy and tumour cure was monitored by following regrowth over 42 days. For treatment at 5 or 30 min after BPD injection, blood flow stasis was limited to tumour microvasculature with lesser response in the surrounding normal microvasculature, indicating selective targeting for damage. No acute changes were observed in vessels when light was given 180 min after BPD injection. Tumour regression after light treatment occurred in all animals given PDT with BPD. Long-term tumour regression was greater in animals treated 5 min after BPD injection and least in animals given treatment 180 min after drug injection. The correlation between the timing for vascular damage and cure implies that blood flow stasis plays a significant role in PDT-induced tumour destruction. (+info)The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. (2/542)
The EWS/TEC gene fusion generated by the t(9;22) chromosomal translocation found in extraskeletal myxoid chondrosarcomas encodes a fusion protein containing the amino-terminal domain of the EWS protein fused to the whole coding sequence of the orphan nuclear receptor TEC. We have compared the DNA-binding and transcriptional activation properties of various TEC isoforms and the corresponding EWS/TEC fusion proteins. Band-shift experiments show that the full-length TEC receptor can efficiently bind the NGFI-B Response Element (NBRE), whereas an isoform lacking the entire carboxyl-terminal domain of the receptor binds much less efficiently the NBRE. Addition of the amino-terminal domain of EWS to either isoforms does not alter significantly their DNA-binding properties to the NBRE. Co-transfection experiments of COS cells and human chondrocytes indicate that whereas TEC moderately activates transcription from a NBRE-containing promoter, the corresponding EWS/TEC fusion protein is a highly potent transcriptional activator of the same promoter, being approximately 270-fold more active than the native receptor. EWS/TEC may thus exert its oncogenic potential in chrondrosarcomas by activating the transcription of target genes involved in cell proliferation. (+info)Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (3/542)
We report here the isolation and sulphation isomer analyses of trisaccharides GalNAcS(beta1,4)GlcA(beta1,3)GalNAcS (in which S indicates sulphate) derived from the non-reducing termini of aggrecan chondroitin sulphate. Rat chondrosarcoma and human aggrecans were digested for 1 h at 37 degrees C with 30 micro-units of endo-chondroitinase ABC per microgram of chondroitin sulphate, and trisaccharides were isolated from the digests by ToyoPearl HW40S gel-filtration chromatography. Four trisaccharide species were identified; their sulphation isomer compositions, as determined by digestion with chondroitinase ACII and fluorescence-based ion-exchange HPLC, were GalNAc4Sbeta1,4GlcAbeta1,3GalNAc4S, GalNAc4Sbeta1,4GlcAbeta1,3GalNAc6S, GalNAc4,6Sbeta1,4GlcAbeta1, 3GalNAc4S and GalNAc4,6Sbeta1,4GlcAbeta1,3GalNAc6S. The abundances of such sequences in chondroitin sulphate on aggrecan from normal (foetal to 72 years of age) and from osteoarthritic human knee cartilages were also established. The results showed that non-reducing terminal GalNAc4S or GalNAc4,6S can be linked to either a 4-sulphated or a 6-sulphated disaccharide, suggesting that the sulphation of the last disaccharide might not have a direct effect on the specificity of chondroitin sulphate terminal GalNAc sulphotransferases. Furthermore, for each aggrecan preparation examined, the 4S-to-6S ratio of all chain interior disaccharides was equivalent to that in the last repeating disaccharides at the non-reducing terminus, suggesting that neither chondroitin 4-sulphotransferase nor chondroitin 6-sulphotransferase shows preferential activity near the chain terminus. (+info)EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. (4/542)
Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether inactivation of both alleles of an EXT gene, according to the tumor-suppressor model, is required for osteochondroma development, or whether a single EXT germline mutation acts in a dominant negative way. We therefore studied loss of heterozygosity and DNA ploidy in eight sporadic and six hereditary osteochondromas. EXT1- and EXT2-mutation analysis was performed in a total of 34 sporadic and hereditary osteochondromas and secondary peripheral chondrosarcomas. We demonstrated osteochondroma to be a true neoplasm, since aneuploidy was found in 4 of 10 osteochondromas. Furthermore, LOH was almost exclusively found at the EXT1 locus in 5 of 14 osteochondromas. Four novel constitutional cDNA alterations were detected in exon 1 of EXT1. Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild-type allele in three osteochondromas, indicating that, in cartilaginous cells of the growth plate, inactivation of both copies of the EXT1 gene is required for osteochondroma formation in hereditary cases. In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene. (+info)Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. (5/542)
The sulfurylase domain of the mouse bifunctional enzyme ATP sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains HXXH and PP-loop motifs. To elucidate the functional importance of these motifs and of conserved arginines and histidines, chemical modification and site-directed mutagenesis studies were performed. Chemical modification of arginines and histidines with phenylglyoxal and diethyl pyrocarbonate, respectively, renders the enzyme inactive in sulfurylase, kinase, and overall assays. Data base searches and sequence comparison of bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number of highly conserved arginines and histidines within the sulfurylase domain. Of these conserved residues, His-425, His-428, and Arg-421 are present within or near the HXXH motif whereas His-506, Arg-510, and Arg-522 residues are present in and around the PP-loop. The functional role of these conserved residues was further studied by site-directed mutagenesis. In the HXXH motif, none of the alanine mutants (H425A, H428A, and R421A) had sulfurylase or overall activity, whereas they all exhibited normal kinase activity. A slight improvement in reverse sulfurylase activity (<10% residual activity) and complete restoration of forward sulfurylase was observed with R421K. Mutants designed to probe the PP-loop requirements included H506A, R510A, R522A, R522K, and D523A. Of these, R510A exhibited normal sulfurylase and kinase activity, R522A and R522K showed no sulfurylase activity, and H506A had normal sulfurylase activity but produced an effect on kinase activity (<10% residual activity). The single aspartate, D523A, which is part of the highly conserved GRD sequence of the PP-loop, affected both sulfurylase and kinase activity. This mutational analysis indicates that the HXXH motif plays a role only in the sulfurylase activity, whereas the PP-loop is involved in both sulfurylase and kinase activities. Residues specific for sulfurylase activity have also been distinguished from those involved in kinase activity. (+info)Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. (6/542)
OBJECTIVE: The aim of the study was to investigate the messenger RNA (mRNA) expression of the disintegrin metalloproteinase MDC15 (metargidin, or ADAM-15) in normal and osteoarthritic (OA) articular cartilage. METHODS: In situ hybridization experiments and reverse transcription-polymerase chain reaction (RT-PCR) were performed on tissue samples of adult normal and OA articular cartilage. RESULTS: MDC15 mRNA could be detected in normal articular cartilage by RT-PCR using tissue-extracted total RNA as a template. However, the mRNA level remained below the sensitivity of in situ hybridization. In contrast, in situ hybridizations of OA cartilage revealed an intense staining with the MDC15-specific riboprobes. The extension of the analysis to chondrosarcomas showed a strong up-regulation of MDC15 mRNA in these malignant transformed cells. CONCLUSION: Our results demonstrate a markedly strong up-regulation of MDC15 in adult OA and neoplastic cartilage compared with adult normal articular cartilage, indicating a potential role of the disintegrin metalloproteinase in cartilage remodeling. (+info)Reconstruction and limb salvage after resection for malignant bone tumour of the proximal humerus. A sling procedure using a free vascularised fibular graft. (7/542)
We assessed the intermediate functional results of eight patients after wide resection of the proximal humerus for malignant bone tumour. We used a free vascularised fibular graft as a functional spacer and a sling procedure to preserve passive scapulohumeral movement. Scapulohumeral arthrodesis was not carried out. Five patients had osteosarcoma, two achondrosarcoma and one a malignant fibrous histiocytoma of the bone. The mean duration of follow-up was 70 months (median, 76) for the seven patients who were still alive at the time of the latest follow-up. One patient died from the disease 12 months after surgery. There were no local recurrences. The functional results were described and graded quantitatively according to the rating system of the Musculoskeletal Tumour Society. Our results were satisfactory with regard to pain, emotional acceptance and manual dexterity. Function and lifting ability were unsatisfactory in two patients. One patient had delayed union between host and graft, but this united after six months without further surgery. Radiographs of the shoulder showed absorption or collapse of the head of the fibula in four of the eight patients and a fracture in another. No functional problems related to absorption or fracture of the head of the fibula were noted. There was no infection or subluxation of the head. We conclude that this is a reasonably effective technique of limb salvage after resection of the proximal humerus. (+info)Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. (8/542)
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. Here we report that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC. Two tumors, one with a novel t(9;17)(q22;q11) variant translocation and one with an apparently normal karyotype, expressed TAF2N-TEC fusion transcripts. In both cases, the chimeric transcripts were shown to contain exon 6 of TAF2N fused to the entire coding region of TEC. This transcript is structurally and functionally very similar to the EWS-TEC fusions. The exchange of the EWS NH2-terminal part with the TAF2N NH2-terminal part in EMC further underscores the oncogenic potential of these protein domains as partners in fusion genes. (+info)
IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...
Xylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycan
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...
Dedifferentiated chondrosarcoma with pathological fracture - femur | Radiology Case | Radiopaedia.org
Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human...
Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation --...
IJMS | Free Full-Text | 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human...
AID 79237 - In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay - PubChem
Clear cell chondrosarcoma of the proximal femur with intrapelvic extension | AVESİS
Functional genomic analyses of the impact of global hypomethylation an by Christopher Allan Hamm
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. - PubMed -...
Bone: Dedifferentiated chondrosarcoma
Not all secondary bone tumours are secondaries. Concurrent metastatic breast carcinoma and chondrosarcoma of the femur | BMJ...
Low-Grade Cartilage Tumors: Background, Differentiation of Benign From Low-Grade Malignant Cartilage Tumors, Case Study 1
Polarity and Ploidy in Peripheral Chondrosarcoma Research Grant
Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm...
Chondrosarcoma
Low-grade chondrosarcoma: sternum | Radiology Case | Radiopaedia.org
Gentaur Molecular :US Biomax \ Osteosarcoma and chondrosarcoma tissue array, with stage, grade and TNM data, 80 cases 80 cores,...
Chondrosarcoma of the greater cornu of the hyoid: a case report and literature review.
Chondrosarcoma - Cow
A Study Of Chondrosarcoma, Bone And Cartilage Derived Cancer - Natural Height Growth
Dedifferentiated Peripheral Chondrosarcoma: A Review of Radiologic Characteristics
NewYork-Presbyterian Queens - Chondrosarcoma
NewYork-Presbyterian Queens - Chondrosarcoma
chondrosarcoma in dogs skull
Chondrosarcoma: Its treatment by radiation, hyperthermia and bleomycin<...
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma...
Chondrosarcoma facts, information, pictures | Encyclopedia.com articles about Chondrosarcoma
Supplementary Material for: MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β...
Robert Nakayama (Japan) | Clinical outcome of clear cell chondrosarcoma: A multicenter study from the Japanese musculoskeletal...
Lirias: Intramuscular mixed tumour with clonal chromosomal changes
Subglottic chondrosarcoma presenting only mild acute-onset dyspnea: a case report and review of the literature.
Plus it
Chondrosarcoma of the Thorax - Semantic Scholar
Clear-cell chondrosarcoma of the maxilla Report of a case
A chondrosarcoma in the anterior mediastinum mimicking a thymoma - Forskning - Region Hovedstaden
Búsqueda | Portal Regional de la BVS
Week 257: Case 2 | Johns Hopkins Surgical Pathology Unknown Conference
An extraskeletal chondrosarcoma of the maxilla. A case report<...
Mouth Cancer (Chondrosarcoma) in Dogs | petMD
Old Maid Cat Lady: Cancer in Cats: Chondrosarcoma
Reconstruction of Acetabular Wall Using Autologous Bone Graft Following Resection of Pelvic Chondrosarcoma: Surgical Technique...
Rare Cancer News & Clinical Trials » Trial - Sarcoma » Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma -...
Throat Cancer (Chondrosarcoma) in Dogs | PetMD
Chondrosarcoma
Chondrosarcoma | Johns Hopkins Medicine
Treatment Options for Chondrosarcoma | Stanford Health Care
GENERIC Chondrosarcoma
Intracranial extraskeletal mesenchymal chondrosarcoma: Case report<...
Most recent papers with the keyword nodular fasciitis | Read by QxMD
Faculty Collaboration Database - Evidence of an association between 6q13-21 chromosome aberrations and locally aggressive...
Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes<...
Do Orthopaedic Oncologists Agree on the Diagnosis and Treatment of Cartilage Tumors of the Appendicular Skeleton?
Radiosurgery for chordomas and chondrosarcomas of the skull base in: Journal of Neurosurgery Volume 107 Issue 4 (2007)
SurgeryXchange - If you are told you need a surgery, you need us
Hemipelvectomia no tratamento de condrossarcoma no acetábulo de cão
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case | Journal of Orthopaedic Case Reports
Chondrosarcoma - OzRadOnc
Plus it
The Radiology Assistant : Differential diagnosis of bone tumors
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor ...
Original Drugstore: Abilify withdrawal causes mania wide pills range!
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
Charged Particle RT for Chordomas and Chondrosarcomas of the Base of Skull or Cervical Spine - Full Text View - ClinicalTrials...
Dedifferentiated chondrosarcomas of the larynx: a report of two cases and review of the literature
Alvin Deguzman
osteosarcoma | The Angeli Foundation
Bone Cancers | Stony Brook Medicine
A Round-About Way To Diagnose Cancer - Veterinary Practice News
Synovis Surgical Innovations Synovis MCA GEM Neurotube (October, 2019)
Leksell Top 25 - Since 2005
Colorectal Plasmocytomas - How do they behave?
Chondroblast
Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... S2CID 44703653.[permanent dead link] Aufderheide, A.C.; Rodríguez-Martín, C.; Langsjoen, O. (2011). "Chondrosarcoma". The ...
List of OMIM disorder codes
GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... 612237; TFG Chondrosarcoma, extraskeletal myxoid; 612237; CSMF Chorea, hereditary benign; 118700; NKX2-1 Choreoacanthocytosis; ...
Bone sarcoma
Most chondrosarcomas develop in the pelvis, legs or arms. Benign counterparts are known as enchondromas. Chondrosarcomas are ... Clear cell Clear cell chondrosarcomas are rare, slow-growing, and seldom spread. Mesenchymal Mesenchymal chondrosarcomas can ... A chondrosarcoma is the type of bone cancer that starts in the cartilage cells. It is the most common type found in adults. ... There are three main types of bone sarcoma based on tissue type - an osteosarcoma, a Ewing's sarcoma, and a chondrosarcoma. The ...
Orthopedic pathology
Depending on the type of chondrosarcoma, it ranges from a slow growth which is able to be removed, to a rapid growth and ... "Chondrosarcoma - Symptoms and causes". Mayo Clinic. Retrieved 2020-04-23. Reference, Genetics Home. "Chordoma". Genetics Home ... There are multiple other bone cancers that are more rare: Chondrosarcoma is identified mainly through the production of ...
BRICHOS family
... related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress ...
Russell Blaylock
Russell L. Blaylock; Ludwig G. Kempe (April 1976). "Chondrosarcoma of the cervical spine". 44 (4). The Journal of Neurosurgery ...
Alan L. Schiller
Coltrera MD, Googe PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML (1986). "Chondrosarcoma of the temporal bone. Diagnosis ...
Synovial osteochondromatosis
Synovial chondrosarcoma Other: Osteochondritis dissecans Sequestrum from osteomyelitis Neuropathic (Charcot) joint Intra- ... Malignant transformation to synovial chondrosarcoma. This is a very rare complication occurring in chronic cases. Treatment ...
Deaths in November 2016
Dawn Coe-Jones, 56, Canadian golfer, chondrosarcoma. Punya Datta, 92, Indian cricketer (Bengal). Louis Devereux, 85, English ...
Chordoma
"Chordoma and chondrosarcoma gene profile: implications for immunotherapy". Cancer Immunology, Immunotherapy. 58 (3): 339-49. ... Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. In most cases, complete surgical ...
Hereditary multiple exostoses
A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems ... Kivioja A, Ervasti H, Kinnunen J, Kaitila I, Wolf M, Böhling T (March 2000). "Chondrosarcoma in a family with multiple ...
Cartilage tumor
They can be either benign (Chondroma) or malignant (chondrosarcoma). Frequently these tumors appear in bone, and not in pre- ...
William DeVries
" "Chondrosarcoma Masquerading as Cardiomyopathy" ; Charles R. Mulligan, Jr, Houman Tavaf-Motamen, Robert Stewart, and William ...
Cartilage
The benign tumors are called chondroma, the malignant ones chondrosarcoma. Tumors arising from other tissues may also produce a ...
IFFO1
However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...
Deaths in June 2008
Michael Turner, 37, American comic book artist and publisher, chondrosarcoma. Irina Baronova, 89, Russian ballerina, last of ...
Enchondroma
When differentiating an enchondroma from a chondrosarcoma, the radiographic image may be equivocal; however, periostitis is not ... "Low-grade chondrosarcoma vs enchondroma: challenges in diagnosis and management". European Radiology. 11 (6): 1054-1057. doi: ...
The Myriad
Drummer Randy Miller died from chondrosarcoma on November 5, 2010. The family set up a place for people to donate money to his ...
Black-necked spitting cobra
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-1607. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda ...
Tenascin C
... is implicated in a number of different cancers such as osteosarcomas, chondrosarcomas, bladder cancer, and ... "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306-14. doi:10.1159/ ...
List of dangerous snakes
B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-7. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda; ...
LECT1
"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its ... "Expression of the chondromodulin-I gene in chondrosarcomas". Cancer Letters. 204 (1): 61-8. doi:10.1016/j.canlet.2003.09.015. ...
Vaccine-associated sarcoma
Fibrosarcoma is the most common VAS; other types include rhabdomyosarcoma, myxosarcoma, chondrosarcoma, malignant fibrous ...
Oral mucosa
Osteosarcoma, chondrosarcoma arise in bone and cartilage, lymphoma in haematological disorders (1). The most common ...
Kostniakomięsak, wolna encyklopedia
Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. „Clin Orthop Relat Res". 459, s. 40-7, Jun ... Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.. „Med Sci Monit". 17 (8), s. RA177-190 ...
Polysomy
Abnormalities of chromosome 13 have been observed in canine osteoid chondrosarcoma and lymphosarcoma. Trisomy 13 in dogs with ...
Ollier disease
While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... The average age of patients of Ollier disease for their first surgery to treat their chondrosarcoma is thirty-three. Some ... Ding, Chang; Chen, Wei; Liu, Fujun; Xiong, Moli; Chen, Jing (July 2019). "Skull Base Chondrosarcoma Caused by Ollier Disease: A ... The incidence of a secondary chondrosarcoma in Ollier disease is most commonly approximated at 25-30% with some projections ...
Chandler Park
C. Park, A. Husain "PET scan negative metastatic chondrosarcoma," American College of Physicians. Research Presentation. ...
Bone tumor
Malignant primary bone tumors include osteosarcoma, chondrosarcoma, Ewing's sarcoma, fibrosarcoma, and other types. While ... such as chondrosarcoma). There is a variety of chemotherapy treatment protocols for bone tumors. The protocol with the best- ...
Bone metastasis
Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Unlike hematological ...
Bulletin 02-15 Chondrosarcoma
EEOICPA BULLETIN NO.02-16 Issue Date: July 15, 2002. ________________________________________________________________. Effective Date: June 12, 2002. ________________________________________________________________. Expiration Date: June 12, 2003. ________________________________________________________________. Subject: Ureter Cancer as a Specified Primary Cancer Background: The Department of Labor (DOL) recently forwarded the medical evidence in a case file to the National Cancer Institute (NCI) for their review and opinion to determine if, for purposes of being considered a specified cancer under the EEOICPA, ureter cancer can be considered urinary bladder cancer.. The expert medical opinion obtained from the NCI indicates that superficial transitional cell carcinomas of the urinary epithelium are biologically identical wherever they arise within the urinary tract and indeed, they are often multifocal. The etiologic (including environmental) influences on urothelial carcinogenesis and the ...
Chondrosarcoma | Encyclopedia.com
Chondrosarcoma Definition Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue ... Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. Central chondrosarcoma occurs within a ... clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the ... There are two different categories of chondrosarcomas-classic chondrosarcomas and variant chondrosarcomas. Together they have ...
Chondrosarcoma
Contact the Orthopaedic Oncology Service at Mass General for more information about treatment for Chondrosarcoma. ... Chondrosarcoma is a malignant cartilaginous tumor. It occurs most often in adults between 40-60 years of age. This tumor ... Chondrosarcoma. Chondrosarcoma is a malignant cartilaginous tumor. It occurs most often in adults between 40-60 years of age. ... Clear cell chondrosarcoma and intermediate or middle grade chondrosarcomas are less likely to spread to other areas. ...
Chondrosarcoma | Johns Hopkins Medicine
Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, ... Chondrosarcoma. Facebook Twitter Linkedin Pinterest Print. What is chondrosarcoma?. Chondrosarcoma is a type of bone cancer ... What causes chondrosarcoma?. The exact cause of chondrosarcoma is not known. There may be a genetic or chromosomal component ... Treatment for chondrosarcoma. Specific treatment for chondrosarcoma will be determined by your healthcare provider based on:. * ...
Chondrosarcoma - Wikipedia
CT scan and gross pathology of a chondrosarcoma 2012-12-18 "Chondrosarcoma : Cancerbackup". Archived from the original on 2008- ... Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Media related to Chondrosarcoma at ... A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. About 30% of bone sarcomas are ... Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. ...
Neurinoma: Chondrosarcoma of the Thoracic Spine | SpringerLink
Katonis P et al (2011) Spinal chondrosarcoma: a review. Sarcoma 2011:378957, 10 pagesCrossRefPubMedPubMedCentralGoogle Scholar ... Strike SA, McCarthy EF (2011) Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J ... Špero M. (2018) Neurinoma: Chondrosarcoma of the Thoracic Spine. In: Neuroradiology - Expect the Unexpected. Springer, Cham. * ... Lloret I et al (2006) Primary spinal chondrosarcoma: radiologic findings with pathological correlation. Acta Radiol 47(1):77-84 ...
Chondrosarcoma: Practice Essentials, Background, Pathophysiology
Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... encoded search term (Chondrosarcoma) and Chondrosarcoma What to Read Next on Medscape. Related Conditions and Diseases. * Fast ... Chondrosarcoma types and grades. Different types of chondrosarcoma have been described, as follows:. * Conventional ... Different types of chondrosarcoma have been described, as follows:. * Conventional chondrosarcoma, which accounts for nearly 90 ...
Myxoid chondrosarcoma - Wikipedia
Myxoid chondrosarcoma is a type of chondrosarcoma. It has been associated with a t(9;22) (q22;q12) EWS/CHN gene fusion. Goh YW ... November 2001). "Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno- ... "Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma". Am. J. ...
Chondrosarcoma in Dogs
Symptoms of Chondrosarcoma in Dogs. Symptoms of chondrosarcoma vary and will depend on the location of the tumor in the dogs ... Spinal chondrosarcoma often shows no visible signs.. If chondrosarcoma has spread to the lungs, the dog may exhibit other ... Treatment of Chondrosarcoma in Dogs. Treatment of chondrosarcoma in dogs must be aggressive. Most dogs are not symptomatic ... Diagnosis of Chondrosarcoma in Dogs. A dog suspected of chondrosarcoma will receive a complete physical and orthopedic ...
Chondrosarcoma - Cedars-Sinai
Chondrosarcoma - Doctors and departments - Mayo Clinic
Chondrosarcoma is a rare type of cancer that primarily affects bone, particularly in the pelvis, hips and base of the skull. ... See a list of publications about chondrosarcoma by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine ... Expand knowledge about some of the most rare varieties of chondrosarcoma. *Improve the ability to tailor the treatment of less- ... Mayo Clinic doctors and researchers continue to study new ways to diagnose and treat chondrosarcomas. Research includes ...
Retracted: Intramedullary Chondrosarcoma of Proximal Humerus
Intramedullary Chondrosarcoma of Proximal Humerus, Pratiksha Yadav, Dolly Thakkar, and S. S. Thind Case Reports in Radiology ... P. Yadav, D. Thakkar, and S. S. Thind, "Intramedullary chondrosarcoma of proximal humerus," Case Reports in Radiology, vol. ... Retracted: Intramedullary Chondrosarcoma of Proximal Humerus. Case Reports in Radiology. Received 1 March 2016; Accepted 1 ... The article titled "Intramedullary Chondrosarcoma of Proximal Humerus" [1] has been retracted as it was found to contain a ...
Treatments for chondrosarcoma - Canadian Cancer Society
The following are treatment options for all stages of chondrosarcoma. The types of treatments given are based on the unique ... It is the most common type of surgery used for chondrosarcoma. It is used to treat a chondrosarcoma in the bones of the skull ... Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. It may be treated with the following ... Treatments for chondrosarcoma. The following are treatment options for chondrosarcoma. Your healthcare team will suggest ...
Chondrosarcoma - Symptoms and causes - Mayo Clinic
Chondrosarcoma is a rare type of cancer that primarily affects bone, particularly in the pelvis, hips and base of the skull. ... Chondrosarcoma is associated with certain genetic mutations. Some varieties of chondrosarcoma arise from the transformation of ... The defining characteristic of a chondrosarcoma is that its cells produce cartilage. Some types of chondrosarcomas grow slowly ... Chondrosarcoma is a rare type of cancer that usually begins in the bones, but can sometimes occur in the soft tissue near bones ...
Synovial Chondrosarcoma Arising in Synovial Chondromatosis
... Scott Evans, Michele Boffano, Samena Chaudhry, Lee Jeys, and Robert ... F. Bertoni, K. K. Unni, J. W. Beabout, and F. H. Sim, "Chondrosarcoma of the synovium," Cancer, vol. 67, pp. 155-162, 1991. ... L. D. Rybak, L. Khaldi, J. Wittig, and G. C. Steiner, "Primary synovial chondrosarcoma of the hip joint in a 45-year-old male: ... W. K. Taconis, R. O. van der Heul, and A. M. M. Taminiau, "Synovial chondrosarcoma: report of a case and review of the ...
Chondrosarcoma of Bone | LUMC
Chondrotumors of bone are the most frequent bone tumors. The majority is asymptomatic and recognised by accident. In the long bones the incidence of low grade sarcoma is regardless the radiological findings very common. Because the incidence of metastasis in these low grade tumors is extremely low research is undertaken to find the treatment with minimal surgery and a high chance of cure. Application of local adjuvant (phenol / alcohol) on a cartilage cell layer is tested in vitro studies. The clinical application in combination with curettage and adjuvant is followed in an at random group of patients. The goal is to establish the recurrences and complications and change in grading by follow up for many years clinically, histology if available and by dynamic MRI. The second part of this study is the study for Ollier disease in the major centres devoted to bone tumors in Europe all members of the EMSOS. The collected data are screened for incidence, presentation and malignant transformation as ...
Chordoma and chondrosarcoma of the skull base
Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma. In: World Health ... Chordoma and chondrosarcoma of the skull base. Author. Carl Snyderman, MD, MBA. Carl Snyderman, MD, MBA ... Chordoma and chondrosarcoma arising in the skull base will be reviewed here. Topics discussed elsewhere include:. ●Chordomas ... Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma ...
Chondrosarcoma - Pipeline Review, H1 2017
... Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline ... www.reportlinker.com/p0923775/Chondrosarcoma-Pipeline-Review-H1.htmlChondrosarcoma ... NEW YORK, June 8, 2017 /PRNewswire/ -- Chondrosarcoma - Pipeline Review, H1 2017SummaryGlobal Markets Directs ... latest Pharmaceutical and Healthcare disease pipeline guide Chondrosarcoma - Pipeline Review, H1 2017, provides an overview of ...
Chondrosarcoma - Harvard Health
However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the… ... Chondrosarcoma is a type of cancer closely related to bone cancer. ... Chondrosarcoma. What Is It?. Published: August, 2014. Chondrosarcoma is a type of cancer closely related to bone cancer. ... However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the ends of bones and lines joints, not in ...
Primary chondrosarcoma of lung | Thorax
Proton Beam Therapy for Chondrosarcoma - Full Text View - ClinicalTrials.gov
Proton Beam Therapy for Chondrosarcoma. The safety and scientific validity of this study is the responsibility of the study ... Chondrosarcoma. Neoplasms, Connective Tissue. Neoplasms, Connective and Soft Tissue. Neoplasms by Histologic Type. Neoplasms. ... Pathologically confirmed Grade 1-3 chondrosarcoma of the skull base. *Contrast enhanced postop MRI or CT if there is clinical ... Patients who have skull base chondrosarcoma require complicated treatment because of its challenging location and nearness to ...
Article - Dedifferentiated chondrosarcoma
Dedifferentiated chondrosarcoma The anteroposterior radiograph of the pelvis shows a lytic, expansile lesion of the right ... Dedifferentiated chondrosarcoma occurs in approximately 11% of patients diagnosed with chondrosarcoma and is considered to be a ... Dedifferentiated chondrosarcoma is an aggressive subtype of chondrosarcoma that is characterized by a cartilaginous component ... Dedifferentiated chondrosarcoma. By Charles E. Lohr, III, MD; Bahair H. Ghazi, MD; Mark H. Schwab, MD; William A. Krantz, Jr., ...
Chondrosarcoma (Nasal and Paranasal Sinus) in Cats - PetPlace
Nasal and Paranasal Sinus Chondrosarcoma in Cats. Nasal and paranasal sinus chondrosarcoma are slow growing, progressive, ... Chondrosarcoma (Nasal and Paranasal Sinus) in Cats. 12 Jul, 2015 Dr. Bari Spielman 12,512 Views ... Chondrosarcoma tends to develop at a younger age than other nasal tumors. There are no breed predilections. ... Overall, nasal and paranasal sinus chondrosarcomas are very aggressive and carry a guarded prognosis. ...
Nose Cancer (Chondrosarcoma) in Cats | petMD
A chondrosarcoma (CSA) is a malignant, invasive and fast spreading tumor in cats. It is relatively uncommon in cats, ... Chondrosarcoma of the Nasal and Paranasal Sinuses in Cats. A chondrosarcoma (CSA) is a malignant, invasive and fast spreading ... Bone Cancer (Chondrosarcoma) in Cats. Chondrosarcoma (CSA) is a type of cancer that affects the cartilage of the body; the ... Throat Cancer (Chondrosarcoma) in Cats Chondrosarcoma (throat cancer) is more common in middle aged and older cats. All breeds ...
Throat Cancer (Chondrosarcoma) in Dogs | PetMD
A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. This is a ... Chondrosarcoma of the Larynx and Trachea in Dogs. A chondrosarcoma is one of several types of laryngeal tumors that can effect ... As with many sarcomas, chondrosarcoma of the larynx and trachea is more common in middle aged and older dogs. All breeds are at ... Being aggressive and malignant in nature, chondrosarcomas of the larynx and trachea are usually life-threatening. Your ...
Cook Children's Health Library - Chondrosarcoma - Conditions - 227283
What is chondrosarcoma? The Liddy Shriver Sarcoma Initiative website. Available at: ...(Click grey area to select URL). Updated ... Chondrosarcoma is graded from 1-4. Grade 1 is a local cancer. Grade 4 shows it has spread to other sites in the body. ... Chondrosarcoma is more common in adults after aged 20-60 years old. Your chances are also higher for:. *Enchondroma-harmless ... Chondrosarcoma is treated with surgery. The tumor is removed with a border of healthy tissue around it. In some cases, ...
Chordomas and Chondrosarcomas of the Skull Base and Spine - 2nd Edition
Purchase Chordomas and Chondrosarcomas of the Skull Base and Spine - 2nd Edition. Print Book & E-Book. ISBN 9780128042571, ... Chordomas and Chondrosarcomas of the Skull Base: Transpetrosal Approaches 18. Chordomas and Chondrosarcomas of the Skull Base: ... Heavy Ion Radiation for Chordomas and Chondrosarcomas. SECTION VI: SPECIAL CONSIDERATIONS. 36. Chordomas and Chondrosarcomas in ... 7. Imaging Cranial Base Chordoma and Chondrosarcoma. 8. Imaging Chordoma and Chondrosarcoma of the Vertebrae and Sacrum ...
Chondro sarcoma | Cancer Survivors Network
I encourage you to do a search of the CSN website by entering the key word "chondrosarcoma" in the search bar at the top of the ... You have similar case with me.I have chondrosarcoma skull base. I had 5 surgeries now. I just wish I could read some ... I had a skull based chondrosarcoma surgically removed from behind my right ear in 1990. Another was diagnosed, growing in the ... I was diagnosed with Chondro sarcoma in September 2015. Another freind of mine was diagnosed with the same cancer around the ...
TumorsTumorHigh-grade chondrosarcomaType of chondrosarcomaAbstractOsteosarcomaMetastaticChemotherapyMetastasisClear cell chondrosarcomaChordomaPrognosisBenignHuman chondrosarcoma cell2017CancerTypes of chondrosarcomaDogs with chondrosarcomaSymptoms of chondrosarcomaTreatment for chondrosarcomaChordomas and ChondrosarcomasSecondaryCell apoptosis in human chondrosarcomaCentral chondrosarcomasPelvisHistologicGrade chondrosarcomaMesenchymal chondrosarcomasRecurrenceCartilaginousOccurLesionsHistologically2018EnchondromasModel of human chondrosarcomaApplied to chondrosarcoma cellsResected low grade chondrosarcomasFusion in mesenchymal chondrosarcomaPrimaryNeoplasmsSurvivalPeriostealNasalApoptosisClinicalBiopsyOncologySubtypeExtraskeletal myxoid chondrosarcomaPeripheralCellsRisk factors for chondrosarcomaBase of thCranialDiagnosis of mesenchymalSkull base chondrosarcomasAggressiveSpineTissueRadiographicRadiation therapy
Tumors35
- Due to the location of chondrosarcoma tumors, the result is often a decrease in the range of motion of limbs, especially tumors occurring on the epiphysis of bones such as those seen in clear cell chondrosarcoma. (encyclopedia.com)
- However, researchers have discovered that chondrosarcomas are sometimes associated with underlying benign bone tumors. (encyclopedia.com)
- Examination of high-grade chondrosarcoma tissue shows clumps of jelly-like cartilage while lower grade tumors have a firmer consistency. (massgeneral.org)
- A chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. (wikipedia.org)
- Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade tumors with low metastatic potential to high-grade, aggressive tumors characterized by early metastasis. (medscape.com)
- Nasal chondrosarcoma may be more easily detected than tumors that occur in other regions of the body. (vetinfo.com)
- Tumors of chondrosarcoma are capable of metastasizing to other organs, and a veterinarian will recommend radiographs (X-rays) of the chest and abdomen to determine if metastasizing has occurred. (vetinfo.com)
- The most common locations for chondrosarcoma tumors are in the pelvis, hip and shoulder. (mayoclinic.org)
- Nasal and paranasal sinus chondrosarcoma are slow growing, progressive, invasive tumors of the nose, nasal cavity and surrounding communicating recesses. (petplace.com)
- Chondrosarcoma tends to develop at a younger age than other nasal tumors. (petplace.com)
- A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. (petmd.com)
- Description - Chondrosarcoma is a malignant neoplasm accounting for 5%-10% of all primary bone tumors reported in dogs. (wearethecure.org)
- Sometimes, however, due to radiopacity, radiolucency or increased radiodensity of certain tumors, it is very difficult to differentiate among osteosarcomas, chondrosarcomas and sarcomas. (wearethecure.org)
- 1 Malignant cartilaginous tumors that are not connected to bone are called extraskeletal chondrosarcomas. (hcplive.com)
- 8,9 Extraskeletal mesenchymal chondrosarcomas are extremely rare, fully malignant tumors with an obscure etiology. (hcplive.com)
- Chondrosarcoma represents approximately 11% of all primary malignant bone tumors. (nih.gov)
- This point mutation has been reported previously in other tumors but not in chondrosarcoma. (ovid.com)
- Moreover, in vivo chondrosarcoma xenograft study revealed a dramatic reduction in tumor volume and the increased SIRT1 and cleaved caspase-3 expressions in tumors by resveratrol treatment. (nature.com)
- Chondrosarcoma is one of the most common primary bone tumors ranking after myeloma and osteosarcoma, accounting for approximately 20% of bone sarcomas and may occur at any age between 10 and 80 years 1 . (nature.com)
- Chondrosarcoma accounts for about 10% of all canine bone tumors and is the second most common primary bone tumor in dogs. (artofphotographyshow.com)
- Learn how scapula tumors in dogs and cats with osteosarcoma, chondrosarcoma or fibrosarcoma might candidates for removal with scapulectomy surgery. (tripawds.com)
- 1 Chondrosarcoma is unique amongst mesenchymal tumors since it has benign precursor lesions, may progress from low- to high grade malignant and may occur in a syndrome. (sarcomahelp.org)
- Common pathologies include chordomas, which are slow-growing, locally aggressive tumors of the bone that arise from embryonic remnants of the notochord, and chondrosarcomas, which are rare malignant cartilaginous tumors that account for 6% of skull base lesions. (oncolink.org)
- Saglik, "Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients," Journal of Orthopaedic Science, vol. (thefreedictionary.com)
- Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. (lu.se)
- article{226d7315-f11d-4d55-98b2-74fb8689a6e6, abstract = {Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. (lu.se)
- Chordomas and chondrosarcomas of the skull base are aggressive and locally destructive tumors with a high tendency for local progression despite treatment. (thejns.org)
- Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. (biomedcentral.com)
- Chondrosarcoma represents a heterogeneous group of cartilage-forming tumors. (aacrjournals.org)
- These tumors are treated by en bloc resection. (aacrjournals.org)
- In general, chondrosarcomas are malignant tumors that mostly arise in the bone. (dovemed.com)
- Chondrosarcomas are cartilage-matrix-forming tumors that make up 20-27% of primary malignant bone tumors and are the third most common primary bone malignancy after multiple myelomas and osteosarcomas. (cureus.com)
- Chondrosarcomas account for 20-27% of primary malignant bone tumors and commonly affect the pelvis and upper and lower extremities [1] . (cureus.com)
- Chondrosarcomas can arise de novo (i.e., primary chondrosarcomas) or from malignant transformation of benign cartilage tumors such as enchondromas or osteochondromas (i.e., secondary chondrosarcomas) [3] . (cureus.com)
- The malignant bone tumors that are categorized as chondrosarcomas display a high potential for metastasis in late-stage disease. (aging-us.com)
Tumor50
- Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue around joints. (encyclopedia.com)
- Depending on the type and location of the chondrosarcoma, the tumor can either be high grade and aggressive or low grade and not as invasive. (encyclopedia.com)
- Chondrosarcoma is a malignant cartilaginous tumor. (massgeneral.org)
- Chondrosarcoma is a malignant cartilaginous tumor, which derives its name because it makes cartilage as it grows. (massgeneral.org)
- Musculoskeletal tumor specialists or orthopedic oncologists are usually chosen to treat chondrosarcoma, unless it is located in the skull, spine, or chest cavity, in which case, a neurosurgeon or thoracic surgeon experienced with sarcomas is chosen. (wikipedia.org)
- Symptoms of chondrosarcoma may vary depending on the location of the tumor. (hopkinsmedicine.org)
- Chondrosarcoma is a malignant tumor that arises from cartilage cells. (vetinfo.com)
- Most dogs suffering from chondrosarcoma do not experience pain unless the tumor affects bones or organs near it's growth. (vetinfo.com)
- Symptoms of chondrosarcoma vary and will depend on the location of the tumor in the dog's body. (vetinfo.com)
- Surgical removal of the tumor is the mainstay of chondrosarcoma treatment. (mayoclinic.org)
- Chondrosarcoma is a tumor that is composed of neoplastic, mesenchymally derived cartilaginous cells and, other than osteosarcoma, is the most prevalent myxoid tumor found in the skeletal system. (appliedradiology.com)
- A chondrosarcoma (CSA) is a malignant , invasive and fast spreading tumor in cats. (petmd.com)
- Dedifferentiation to leiomyosarcoma, giant cell tumor , and rarely, clear-cell chondrosarcoma or rhabdomyosarcoma has been reported. (atlasgeneticsoncology.org)
- Chondrosarcoma is a primary bone tumor that has several different grades and variants. (ovid.com)
- Chondrosarcoma is a malignant primary bone tumor. (nature.com)
- Here, we investigated the role of SIRT1 induction by resveratrol in human chondrosarcoma cell growth and tumor progression. (nature.com)
- The aims of this study were to assess the potential of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) for tumor grading in chondrosarcoma patients and to evaluate the role of standardized uptake value (SUV) as a parameter for prediction of patient outcome. (nih.gov)
- Pretherapeutic tumor SUV obtained by FDG PET imaging was a useful parameter for tumor grading and prediction of outcome in chondrosarcoma patients. (nih.gov)
- Chondrosarcoma in Dogs Life Expectancy Saved by Your Dog's Health Matters Baby Animals Pictures Cute Animal Pictures Animals And Pets Animal Pics Funny Pictures Fluffy Animals Smiling Animals Small Animals Wild Animals The pet's life expectancy largely depends on the location and nature of the tumor, as well as the exact time it was diagnosed. (artofphotographyshow.com)
- Nasal chondrosarcoma involving the entire left nasal cavity with breach of the central region of the nasal septum and tumor extension into the right nasal cavity. (merckvetmanual.com)
- Chondrosarcoma is the most common malignant bone tumor in the foot in some reported series. (bonetumor.org)
- This tumor has several subtypes, including clear cell chondrosarcoma, and mesenchymal chondrosarcoma, which can occur in bone and in the soft tissues, where it presents as as an innocent bump. (bonetumor.org)
- Most often, chondrosarcoma occurs from normal cartilage cells, but it may also stem from a preexisting benign (noncancerous) bone or cartilage tumor. (nyhq.org)
- Chondrosarcoma is the second most frequent malignant bone tumor that forms cartilage. (sarcomahelp.org)
- Insulin increases synthesis of mucopolysaccharides in the chondrocytes whereas it elevates synthesis of proteoglycans in the tumor cells obtained from the chondrosarcoma cells. (thefreedictionary.com)
- Chondrosarcoma is a malignant mesenchymal tumor that produces cartilaginous matrix. (thefreedictionary.com)
- According to the American College of Veterinary Surgeons , chondrosarcoma is the second most common primary tumor of the axial and appendicular skeleton, after osteosarcoma. (tripawds.com)
- Although Dr. Chretin doesn't recommend chemotherapy as a primary treatment for chondrosarcoma, if the dog isn't a candidate for surgery, the tumor can be treated with radiation therapy to alleviate pain. (tripawds.com)
- Most often, chondrosarcoma occurs from normal cartilage cells, but it may also stem from a preexisting benign (non-cancerous) bone or cartilage tumor. (mydochub.com)
- Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. (biomedsearch.com)
- The patient underwent tumor resection and a biopsy confirmed the presence of a mesenchymal chondrosarcoma. (springermedizin.at)
- However, the inhibition of the survivin pathway by the combined treatment with IR and bortezomib, observed in the present study, revealed a novel aspect in the tumor biology of chondrosarcoma 3D spheroid cultures and may represent a potential target for therapy. (spandidos-publications.com)
- One of the most common types of bone cancer in adults, chondrosarcoma is a malignant tumor made up of cartilage-producing cells. (uabmedicine.org)
- Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma. (semanticscholar.org)
- Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy. (biomedcentral.com)
- We documented changes in gene expression that accompany changes in tumor phenotype, and these gene expression changes provide insight into the pathways that may play a role in the development and progression of chondrosarcoma. (biomedcentral.com)
- Chondrosarcoma is a common primary malignant tumor of the bone that can metastasize through the vascular system to other organs. (ovid.com)
- Overexpression of resistin in chondrosarcoma cells significantly enhanced VEGF-C production and LECs-associated lymphangiogenesis in vitro and tumor-related lymphangiogenesis in vivo. (ovid.com)
- We suggest that resistin may represent a molecular target in VEGF-C-associated tumor lymphangiogenesis in chondrosarcoma metastasis. (ovid.com)
- Chondrosarcoma is a malignant cartilage forming bone tumor, in which mutations altering isocitrate dehydrogenase-1 and -2 (IDH1 and IDH2) activity have been identified as potential driver mutations. (aacrjournals.org)
- The far most prevalent subtype (72% of the cases) is conventional central chondrosarcoma, in which the tumor arises centrally in the medulla of the bone. (aacrjournals.org)
- This subtype can be histologically subdivided into atypical cartilaginous tumor (ACT), grade II and grade III chondrosarcomas. (aacrjournals.org)
- Chondrosarcoma patients with unresectable disease, due to tumor location, tumor size, or extensive metastatic disease, have a 5-year survival of only 2% as the overall efficacy of chemotherapy is limited ( 8, 9 ). (aacrjournals.org)
- In this study, we showed a clinical correlation between adiponectin and VEGF-C as well as tumor stage in human chondrosarcoma tissues. (clinsci.org)
- Loss of DNA methylation was accompanied by an increase in invasiveness of the rat chondrosarcoma cells, in vitro, as well as by an increase in tumor growth in vivo. (luriechildrens.org)
- S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. (aacrjournals.org)
- In vivo anti-tumor activity of BEZ235, a phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor, was evaluated in a chondrosarcoma xenograft model. (aacrjournals.org)
- Tumor growth was similarly inhibited in a xenograft model of chondrosarcoma. (aacrjournals.org)
- Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation -- Martin et al. (aacrjournals.org)
- Although chondrosarcomas are better known for their involvement of the pelvis and extremities, they are the most common malignant tumor of the chest wall [5] . (cureus.com)
High-grade chondrosarcoma7
- Dedifferentiated chondrosarcoma and high-grade chondrosarcoma are most likely to spread (metastasize) to other areas. (massgeneral.org)
- Recent studies have shown that induction of apoptosis in high-grade chondrosarcoma, both directly and by enhancement of response to chemotherapy and radiation, is a valid therapeutic strategy. (wikipedia.org)
- Galoian K, Temple TH, Galoyan A. Cytostatic effect of the hypothalamic cytokine PRP-1 is mediated by mTOR and cMyc inhibition in high grade chondrosarcoma. (springer.com)
- however, the survival of high-grade chondrosarcoma patients is still poor after surgical therapy. (nature.com)
- The lesions were divided into four histological grades: atypical enchondroma (grade 0), low-grade chondrosarcoma (grade I), intermediate grade chondrosarcoma (grade II), and high-grade chondrosarcoma (grade III). (scielo.org.za)
- Final diagnosis: high-grade chondrosarcoma . (radiopaedia.org)
- Background: Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very important because the treatment strategies for these diseases are completely different. (ebscohost.com)
Type of chondrosarcoma7
- As the name implies, cells biopsied from this type of chondrosarcoma appear clear with many large vacuoles. (encyclopedia.com)
- Myxoid chondrosarcoma is a type of chondrosarcoma. (wikipedia.org)
- A dedifferentiated chondrosarcoma tumour is treated like an osteosarcoma tumour because it is a more aggressive type of chondrosarcoma. (cancer.ca)
- Mesenchymal chondrosarcoma is an aggressive, high-grade type of chondrosarcoma. (cancer.ca)
- However, one rare type of chondrosarcoma develops in the soft tissues, such as the muscles, nerves, or fat, of the arms and legs. (harvard.edu)
- A rare type of chondrosarcoma called extraskeletal chondrosarcoma does not form in bone cartilage. (linkedlifedata.com)
- The use of chemotherapy may depend on the type of chondrosarcoma that you have. (coliseumhealthsystem.com)
Abstract1
- ABSTRACT: Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. (scirp.org)
Osteosarcoma8
- Dedifferentiated chondrosarcoma may be treated with some of the same chemotherapy drugs that are used for osteosarcoma . (cancer.ca)
- The non-cartilaginous component of dedifferentiated chondrosarcoma is generally an osteosarcoma , a fibrosarcoma, or a malignant fibrous histiocytoma. (atlasgeneticsoncology.org)
- major challenges are the distinction between grade I chondrosarcomas and chondromas, and the differential diagnosis with chondroblastic osteosarcoma and chondroid chordoma. (nih.gov)
- Is chondrosarcoma as fast growing as osteosarcoma? (artofphotographyshow.com)
- Rare primary bone malignancies such as clear cell chondrosarcoma and giant cell rich osteosarcoma can also mimic GCTB but often have more destructive features, adjacent bone marrow edema, and/or a soft tissue mass component. (thefreedictionary.com)
- However, compared to osteosarcoma, chondrosarcoma is uncommon. (tripawds.com)
- Like osteosarcoma, chondrosarcoma is a metastatic disease that spreads. (tripawds.com)
- There are 4 cases of canine primary osteosarcoma and 5 chondrosarcomas in the COPLOW collection. (arvojournals.org)
Metastatic7
- Lytic lesions may be detected by cortical perforation and possible extension, which can result in a large mass. 4 Due to its locally invasive nature, high rates of recurrence, and metastatic seeding of the skeleton and lungs, dedifferentiated chondrosarcoma carries a grave prognosis. (appliedradiology.com)
- Purpose of review: The prognosis of patients with unresectable or metastatic chondrosarcoma of the bone is poor. (medworm.com)
- Dedifferentiated chondrosarcoma accounts for approximately 10% of all chondrosarcomas and shows an increased growth rate and rapid metastatic spread in comparison with ordinary chondrosarcomas. (atlasgeneticsoncology.org)
- Histologically 46 tumours were low-grade (grade 0 or I) chondrosarcoma (82%), there were nine cases of intermediate (grade II) chondrosarcoma (16%), and one patient had a metastatic mesenchymal chondrosarcoma. (scielo.org.za)
- Two patients died, one with metastatic mesenchymal chondrosarcoma involving the scapula, and the other with an intermediate (grade 2) lesion of the pelvis. (scielo.org.za)
- Grade 1 chondrosarcomas have little or no metastatic potential and are often difficult to distinguish from painful benign enchondromas. (ebscohost.com)
- A key step in the metastatic process, lymphangiogenesis, involves vascular endothelial growth factor-C (VEGF-C). However, the effects of lymphangiogenesis in chondrosarcoma metastasis remain to be clarified. (ovid.com)
Chemotherapy7
- Chemotherapy has not been shown to be effective when treating chondrosarcoma in dogs. (vetinfo.com)
- Chemotherapy is not used for low-grade chondrosarcoma because it has not been shown to help improve survival. (cancer.ca)
- Chondrosarcomas are in general resistant to chemotherapy and radiotherapy. (medworm.com)
- Due to its poor response to both radiotherapy and chemotherapy, the management of chondrosarcoma faces a complicated challenge 2 . (nature.com)
- Dr. Chretin states that there haven't been any good, large scale studies done on dogs with chondrosarcoma who were treated with chemotherapy. (tripawds.com)
- Chondrosarcomas represent a heterogeneous group of primary bone cancers that are characterized by hyaline cartilaginous neoplastic tissue and are predominantly resistant to radiation and chemotherapy. (spandidos-publications.com)
- Because of their hypovascularity and slow mitotic activity, conventional chondrosarcomas are distinguished for their resistance to chemotherapy and radiation therapy [3] . (cureus.com)
Metastasis7
- Follow up scans are extremely important for chondrosarcoma to make sure there has been no recurrence or metastasis, which usually occurs in the lungs. (wikipedia.org)
- Not one patient with low-grade chondrosarcoma treated adequately with local curettage and surgical adjuvant therapy presented with local recurrence or distal metastasis. (scielo.org.za)
- Furthermore, specific functional analysis indicates that thymosin-β4 may have a role in chondrosarcoma metastasis. (biomedcentral.com)
- Two other subtypes with a worse prognosis are dedifferentiated chondrosarcoma, a highly malignant variant ( 4 ), and mesenchymal chondrosarcoma, a rare aggressive subtype in which distant metastasis can be identified even after 20 years ( 5-7 ). (aacrjournals.org)
- Chondrosarcoma is the second most frequently occurring type of bone malignancy that is characterized by the distant metastasis propensity. (clinsci.org)
- Thus, adiponectin could serve as a therapeutic target in chondrosarcoma metastasis and lymphangiogenesis. (clinsci.org)
- The phosphorylation of sphingosine by sphingosine kinase enzymes SphK1 and SphK2 generates sphingosine-1-phosphate (S1P), which inhibits human chondrosarcoma cell migration, while SphK1 overexpression suppresses lung metastasis of chondrosarcoma. (aging-us.com)
Clear cell chondrosarcoma6
- There are three variant chondrosarcomas: clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. (encyclopedia.com)
- Clear cell chondrosarcoma is the most rare form of chondrosarcoma. (encyclopedia.com)
- However, as opposed to clear cell chondrosarcoma, it is highly malignant and frequently metastasizes, commonly to the lungs, lymph nodes and other bones. (encyclopedia.com)
- Clear cell chondrosarcoma and intermediate or middle grade chondrosarcomas are less likely to spread to other areas. (massgeneral.org)
- Clear cell chondrosarcoma of bone: a report of 8 cases. (thefreedictionary.com)
- Clear cell chondrosarcoma is an extremely rare malignant neoplasm. (bmj.com)
Chordoma4
- Chordoma and chondrosarcoma arising in the skull base will be reviewed here. (uptodate.com)
- Histologically proven chordoma or chondrosarcoma. (knowcancer.com)
- We read with great interest the recent article entitled "Diffusion-Weighted MRI: Distinction of Skull Base Chordoma from Chondrosarcoma" by Yeom et al. (ajnr.org)
- We have now replicated these findings with a sample of 14 chordoma and 10 chondrosarcoma cases from our own institution. (ajnr.org)
Prognosis7
- Overall, nasal and paranasal sinus chondrosarcomas are very aggressive and carry a guarded prognosis. (petplace.com)
- This review discusses recent developments in the characterization of molecular pathways involved in the oncogenesis of chondrosarcoma that should be explored to improve prognosis of patients with advanced chondrosarcoma. (medworm.com)
- Summary: As many different genetic alterations in chondrosarcoma have been identified, it is of the utmost importance to classify druggable targets that may improve the prognosis of chondrosarcoma patients. (medworm.com)
- Therapeutic intervention studies of these new targets emerging from preclinical studies are of highest importance to improve prognosis of chondrosarcoma patients with advanced disease. (medworm.com)
- Prognosis - The reported median survival of dogs with nasal chondrosarcoma has been found to be 210 days to 580 days with various treatments like radiation therapy, rhinotomy (incision made into the nose to drain accumulated pus) and radiation therapy combined and rhinotomy alone. (wearethecure.org)
- Chondrosarcomas frequently recur and, thus, follow up scans are vital to a good long-term prognosis. (knowcancer.com)
- Chordomas have a significantly worse prognosis than chondrosarcomas, with 5-year progression-free survival estimated at 80% for chondrosarcomas but only 40% for chordomas. (ajnr.org)
Benign7
- Benign cartilage lesions can be difficult to differentiate from slow-growing, low-grade chondrosarcomas. (medscape.com)
- Secondary chondrosarcoma can occur in a previously benign cartilaginous lesion. (medscape.com)
- Some varieties of chondrosarcoma arise from the transformation of benign cartilage lesions into cancers. (mayoclinic.org)
- Most chondrosarcomas are low grade, but dedifferentiated chondrosarcoma can occur in the setting of a longstanding benign cartilage lesion such as enchondroma. (bonetumor.org)
- It may have focal calcification, mucoid I degeneration, or necrosis.Histologically, chondrosarcoma is differentiated from benign cartilage growths by enlarged plump nuclei, multiple cells per lacunae, binucleated cells, and hyperchromic nuclear pleomorphism. (bonetumor.org)
- Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (linkedlifedata.com)
- It is possible that low-grade chondrosarcoma may have a far more benign course than other chondrosarcomas and, if treated adequately, may require a far less vigorous follow-up regimen. (scielo.org.za)
Human chondrosarcoma cell1
- Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. (mdpi.com)
20172
- Report Highlights Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Chondrosarcoma - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Chondrosarcoma (Oncology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (medindia.net)
- GlobalData's clinical trial report, "Chondrosarcoma Global Clinical Trials Review, H1, 2017" provides an overview of Chondrosarcoma clinical trials scenario. (sandlerresearch.org)
Cancer16
- Chondrosarcoma is a bone sarcoma, a primary cancer composed of cells derived from transformed cells that produce cartilage. (wikipedia.org)
- Chondrosarcoma is a type of bone cancer that develops in cartilage cells. (hopkinsmedicine.org)
- Chondrosarcoma is the second most common type of primary bone cancer. (hopkinsmedicine.org)
- Chondrosarcoma is the second most common bone cancer in dogs. (vetinfo.com)
- The article titled "Intramedullary Chondrosarcoma of Proximal Humerus" [ 1 ] has been retracted as it was found to contain a substantial amount of material, without referencing, from the following published article: "Review: Imaging of Chondrosarcomas," by L. Ollivier, D. Vanel, and J. Leclère, in Cancer Imaging. (hindawi.com)
- Chondrosarcoma is a rare type of cancer that usually begins in the bones, but can sometimes occur in the soft tissue near bones. (mayoclinic.org)
- Chondrosarcoma is a type of cancer closely related to bone cancer. (harvard.edu)
- Treatment - Chondrosarcoma is amenable to surgery because a reliable adjuvant chemotherapeutic agent does not exist for this type of cancer. (wearethecure.org)
- Chondrosarcoma is a cartilaginous cancer (a cartilage-based bone cancer) that represents approximately 25% of all primary bone cancer cases. (knowcancer.com)
- Chondrosarcoma (CSA) of the bone is a fast spreading and malignant form of cancer, which, if not diagnosed and treated early, can be life threatening. (artofphotographyshow.com)
- Interview about chondrosarcoma bone cancer in dogs with information and treatment options as shared by Dr. Johnny Chretin of VCA West Los Angeles Animal Specialty Oncology Clinic. (tripawds.com)
- One dog's story about symptoms and diagnosis of canine chondrosarcoma bone cancer in the spine. (tripawds.com)
- Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. (nyhq.org)
- Chondrosarcoma is the second most common type of primary bone cancer in adults. (brighamandwomens.org)
- However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. (mdpi.com)
- Chondrosarcoma is commonly a primary cancer, meaning it originates in the bone, rather than spreading from another organ. (uabmedicine.org)
Types of chondrosarcoma2
- Surgery is the main treatment for most types of chondrosarcoma. (cancer.ca)
- There are three additional types of chondrosarcoma. (bonetumor.org)
Dogs with chondrosarcoma3
- However, the median survival time of dogs with chondrosarcoma of the ribs varies largely. (wearethecure.org)
- Medical records were retrospectively reviewed to identify dogs with chondrosarcoma of bone in potentially surgically accessible sites. (artofphotographyshow.com)
- Dogs with chondrosarcoma of the skull have life expectancy between 210 and 580 days - in our case it was 180 days - after the first alterations on the eye of the dog occurred. (artofphotographyshow.com)
Symptoms of chondrosarcoma2
- What are the symptoms of chondrosarcoma? (hopkinsmedicine.org)
- The following are the most common symptoms of chondrosarcoma. (hopkinsmedicine.org)
Treatment for chondrosarcoma3
- Treatment for chondrosarcoma is almost entirely surgical. (massgeneral.org)
- citation needed] Surgery is the main form of treatment for chondrosarcoma. (wikipedia.org)
- The dog's condition is an important factor when determining the course of treatment for chondrosarcoma. (vetinfo.com)
Chordomas and Chondrosarcomas6
- Winn HR. Chordomas and chondrosarcomas. (mayoclinic.org)
- Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. (elsevier.com)
- This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. (elsevier.com)
- Adjuvant radiation is recommended for chordomas and chondrosarcomas, as opposed to delayed radiation initiated at recurrence. (oncolink.org)
- PBT immediately following surgery is favorable in patients with clival chordomas and chondrosarcomas in comparison to PBT at the time of recurrence. (oncolink.org)
- Stereotactic radiosurgery is an important option for skull base chordomas and chondrosarcomas either as primary or adjunctive treatment. (thejns.org)
Secondary6
- A small minority of secondary chondrosarcomas occur in patients with Maffucci syndrome and Ollier disease. (wikipedia.org)
- Chondrosarcoma (primary, secondary, dedifferentiated and clear cell). (mayoclinic.org)
- Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma. (uptodate.com)
- There was a stalk that had a radiographic appearance consistent with a secondary chondrosarcoma. (aaos.org)
- Central chondrosarcoma is most common 1,3 and may be secondary to an enchondroma. (sarcomahelp.org)
- Approximately 15% 3 of chondrosarcomas (secondary (peripheral) chondrosarcoma) are located at the surface of bone and result from malignant transformation of osteochondroma. (sarcomahelp.org)
Cell apoptosis in human chondrosarcoma1
- Resveratrol significantly decreased cell viability and induced cell apoptosis in human chondrosarcoma cells in a dose-dependent manner. (nature.com)
Central chondrosarcomas3
- Central chondrosarcomas may be low, medium or high grade. (massgeneral.org)
- The rate of dedifferentiation is 13%-15% in central chondrosarcomas compared to 4%-5% in peripheral chondrosarcomas. (atlasgeneticsoncology.org)
- Functional NRAS mutations were found in 12% of conventional central chondrosarcomas. (aacrjournals.org)
Pelvis8
- Chondrosarcoma primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, or knee. (hopkinsmedicine.org)
- Chondrosarcoma usually affects the ribs, nasal bones and pelvis. (vetinfo.com)
- It is used to treat a chondrosarcoma in the bones of the skull or spine, as well as in the arm, leg and pelvis. (cancer.ca)
- Limb-sparing surgery may be used to treat chondrosarcoma in the arm, leg and pelvis. (cancer.ca)
- Chondrosarcoma is considered as a common primary bone sarcoma, which is ranked as the third primary bone malignancy One in five cases of bone sarcomas are due to chondrosarcoma , and half of all cases affect the pelvis (1). (thefreedictionary.com)
- Little has been published about the outcome of patients with recurrent chondrosarcoma of the pelvis. (semanticscholar.org)
- Survival analysis of patients with chondrosarcomas of the pelvis. (semanticscholar.org)
- Chondrosarcomas frequently affect the pelvis and upper and lower extremities. (cureus.com)
Histologic4
- Performing a truly representative biopsy of a chondrosarcoma is challenging because the lesion is composed of areas that carry different histologic grades. (medscape.com)
- Mesenchymal chondrosarcoma is a rare variant with a bimorphic histologic picture of low grade cartilaginous cells and hypercellular small, uniform, and undifferentiated cells that resemble Ewing's sarcoma. (bonetumor.org)
- RT-PCR or FISH evidence of this HEY1-NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas. (nih.gov)
- Chondrosarcoma patients, especially those of high histologic grade with lower expression and hypermethylation of NAPRT, may benefit from inhibition of the NAD synthesis pathway. (aacrjournals.org)
Grade chondrosarcoma12
- It is characterized by the presence of a mix of low-grade chondrosarcoma and has undergone malignant degeneration, producing a fully malignant soft tissue mass that is no longer identifiable as cartilage. (encyclopedia.com)
- It may be used after curettage to treat some small, low-grade chondrosarcoma tumours. (cancer.ca)
- original magnification, 10x) shows abrupt transition between a low grade chondrosarcoma (left) and a high grade spindle cell sarcoma (right). (atlasgeneticsoncology.org)
- Others advocate that dedifferentiation is the result of two differing clones of cells, one of which differentiates into a low-grade chondrosarcoma, while the other fails to differentiate and displays features of a high-grade sarcoma. (atlasgeneticsoncology.org)
- Treatment for low grade chondrosarcoma may include curettage or marginal excision. (bonetumor.org)
- Low grade chondrosarcoma is very close in appearance to enchondromas and osteochondromas and has occasional binucleated cells. (bonetumor.org)
- Biopsy of the solid lesion demonstrated a low-grade chondrosarcoma, while no tissue sample of the cystic lesion could be retrieved. (frontiersin.org)
- Sagittal, contrast-enhanced T1-weighted MR-image showing a mass (7 × 8 × 15 mm, height x depth x width) with peripheral contrast-uptake that was later identified as a low-grade chondrosarcoma. (frontiersin.org)
- Low grade chondrosarcoma: is long-term follow-up necessary? (scielo.org.za)
- Currently, the follow-up regimen for patients treated for low-grade chondrosarcoma is similar to that of all chondrosarcomas. (scielo.org.za)
- This appears to be adequate for timely detection and treatment of any local recurrence of low-grade chondrosarcoma. (scielo.org.za)
- These are all characteristics of a low-grade chondrosarcoma. (biomedsearch.com)
Mesenchymal chondrosarcomas5
- Lightenstein and Bernstein first described mesenchymal chondrosarcomas in 1959, and Dowling reported the first case of an extraskeletal mesenchymal chondrosarcoma in 1964. (hcplive.com)
- Extraskeletal mesenchymal chondrosarcomas involve muscles or the central nervous system. (hcplive.com)
- The novel HEY1-NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas. (nih.gov)
- It is true that molecular testing with its increasing availability now can be helpful in establishing diagnosis of mesenchymal chondrosarcomas, particularly those with less than optimal pathologic features or sampling. (springer.com)
- Mesenchymal chondrosarcomas constitute about 5% of all chondrosarcomas. (dovemed.com)
Recurrence4
- The grade of chondrosarcoma, outcome and tumour recurrence was evaluated in these patients. (scielo.org.za)
- We believe that adequately treated low-grade chondrosarcomas have a very low local recurrence rate. (scielo.org.za)
- 18F-FDG PET/CT in Diagnostic and Prognostic Evaluation of Patients With Suspected Recurrence of Chondrosarcoma. (semanticscholar.org)
- Oncologic outcome after local recurrence of chondrosarcoma: Analysis of prognostic factors. (semanticscholar.org)
Cartilaginous5
- Dedifferentiated chondrosarcoma is an aggressive subtype of chondrosarcoma that is characterized by a cartilaginous component and a highly lytic sarcomatous component. (appliedradiology.com)
- It is a subtype of chondrosarcoma, a term that includes a heterogeneous group of lesions with varied clinical behaviour and morphological features that share the common feature arising from ossified cartilage or cartilaginous rests. (scielo.org.za)
- Microscopic evaluation revealed a biomorphic pattern composed of undifferentiated round or oval cells resembling embryonal mesenchyme and well-differentiated cartilaginous tissue, which is a characteristic finding of extraskeletal mesenchymal chondrosarcoma (Figure 4). (hcplive.com)
- Chondrosarcomas are heterogeneous, mostly slow-growing, primary malignancies of the bone that are characterized by hyaline cartilaginous neoplastic tissue formation ( 1 , 2 ). (spandidos-publications.com)
- Intracranial chondrosarcomas are cartilaginous tumours that are extremely rare with an estimated incidence of less than 0.16% of all intracranial neoplasms. (minervamedica.it)
Occur6
- Seventy-six percent of primary chondrosarcomas occur centrally within a bone. (encyclopedia.com)
- Although there are exceptions, chondrosarcomas occur mainly in older adults forty to sixty years old and typically occur more in men than in women. (encyclopedia.com)
- While chondrosarcoma can occur at any age, the most prevalent variety typically affects middle-aged to older adults. (mayoclinic.org)
- Chondrosarcomas most often occur in males. (thefreedictionary.com)
- Chondrosarcoma can occur at any age but is more common in people older than 40 years. (linkedlifedata.com)
- These results indicate, in agreement with our previous kinetic data, that the major part of the xylosyl transfer to the chondrosarcoma proteoglycan core protein precursor must occur late in the processing sequence, i.e. after about 85% of its intracellular lifetime and no more than 7 min before the addition of the rest of the chondroitin sulfate chain. (lu.se)
Lesions4
- These lesions sometimes transform into chondrosarcoma. (mayoclinic.org)
- For such cystic lesions in combination with chondrosarcoma, a treatment course with steroids should be considered along with surgical exploration necessary to obtain the diagnosis and for potential reduction of mass-effect on the medulla oblongata. (frontiersin.org)
- One such tumour, the chondrosarcoma, the most malignant cartilage tumour, represents 0.15% of all cranial space occupying lesions and 6% of all skull base tumours. (bmj.com)
- Objective: To assess if diffusion-weighted MRI (DWI) can differentiate between central enchondromas and chondrosarcomas (CS) and if DWI can distinguish low-grade chondroid lesions from high-grade CS. (ebscohost.com)
Histologically1
- Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. (thejns.org)
20181
- Špero M. (2018) Neurinoma: Chondrosarcoma of the Thoracic Spine. (springer.com)
Enchondromas2
- Patients with Ollier's disease (multiple enchondromatosis) or Maffucci's syndrome (multiple enchondromas and hemangiomas) are at much higher risk of chondrosarcoma than the normal population and often present in the third and fourth decade. (bonetumor.org)
- There is a risk of ~35% that the enchondromas turn into malignant chondrosarcomas. (sarcomahelp.org)
Model of human chondrosarcoma1
- To examine its effect on tumorigenesis, we induced DNA demethylation in a rat model of human chondrosarcoma using 5-aza-2-deoxycytidine. (luriechildrens.org)
Applied to chondrosarcoma cells2
- Using a three‑dimensional (3D) spheroid model, 0‑20 Gy of IR was applied to chondrosarcoma cells and healthy human chondrocytes. (spandidos-publications.com)
- Small interfering RNA or small molecule inhibitors against RTKs or downstream signaling proteins were applied to chondrosarcoma cells and changes in biochemical signaling, cell cycle, and cell viability were determined. (aacrjournals.org)
Resected low grade chondrosarcomas1
- Patients with adequately resected low grade chondrosarcomas have an excellent survival rate. (bonetumor.org)
Fusion in mesenchymal chondrosarcoma1
- Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data. (nih.gov)
Primary8
- Unlike other primary bone sarcomas that mainly affect children and adolescents, a chondrosarcoma can present at any age. (wikipedia.org)
- Lloret I et al (2006) Primary spinal chondrosarcoma: radiologic findings with pathological correlation. (springer.com)
- A case of primary chondrosarcoma of the lung is described in a 64-year-old man. (bmj.com)
- When a primary chondrosarcoma originates within a bone organ (organs of the skeletal system) it is called central or medullary chondrosarcoma but when it develops in the periosteum (membrane lining the outer surface of all bones) it is known as peripheral chondrosarcoma. (wearethecure.org)
- Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. (biomedsearch.com)
- To describe a case series of primary ocular osteosarcomas and chondrosarcomas in dogs. (arvojournals.org)
- The COPLOW database was mined for cases of primary osteosarcomas and chondrosarcomas. (arvojournals.org)
- Canine primary osteosarcomas and chondrosarcomas frequently present with hyphema, uveitis, and increased intraocular pressure in older dogs. (arvojournals.org)
Neoplasms2
- Among the less common are chondrosarcoma, fibrosarcoma , and malignant fibrous histiocytoma , all of which arise from spindle cell neoplasms. (encyclopedia.com)
- Extraskeletal chondrosarcomas are mesenchymal neoplasms of soft tissues and visceral organs that produce neoplastic chondrocytes in a fibrillary matrix. (artofphotographyshow.com)
Survival1
- Chondrosarcoma Survival Rate. (artofphotographyshow.com)
Periosteal2
- On plain radiographs, chondrosarcoma of the long bones is a fusiform, lucent defect with scalloping of the inner cortex and periosteal reaction. (bonetumor.org)
- Khalil S, Al-Rahawan MG, Al-Rahawan MM. Periosteal mesenchymal chondrosarcoma of the tibia. (springer.com)
Nasal3
- The nasal cavity on the other hand is also highly susceptible to developing chondrosarcoma. (wearethecure.org)
- Nasal chondrosarcoma may metastasize to adjacent sinuses or invade overlying bone and penetrate adjacent soft tissues. (wearethecure.org)
- In case of nasal chondrosarcoma, the signs may include sneezing, unilateral and sometimes bilateral purulent (pus), bloody discharge and nasal obstruction followed with bone destruction. (wearethecure.org)
Apoptosis1
- These results suggest that resveratrol induces chondrosarcoma cell apoptosis via a SIRT1-activated NF-κB deacetylation and exhibits anti-chondrosarcoma activity in vivo . (nature.com)
Clinical8
- The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. (clinicaltrials.gov)
- These specific alterations can be employed for use in clinical interventions in advanced chondrosarcoma. (medworm.com)
- Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study. (artofphotographyshow.com)
- The available data in the literature (177 cases), two current clinical patients, and cases which occurred in The Netherlands (13) were reviewed concerning the clinical presentation, pathological features, radiological data, and treatment options of chondrosarcoma of the cranial base. (bmj.com)
- UAB is an active participant in research and clinical trials for the diagnosis and treatment of chondrosarcoma. (uabmedicine.org)
- This report provides top line data relating to the clinical trials on Chondrosarcoma. (sandlerresearch.org)
- Resistin levels were positively correlated with VEGF-C-dependent lymphangiogenesis via the down-regulation of miR-186 expression in clinical samples from chondrosarcoma tissue. (ovid.com)
- What are the Clinical Indications for performing the Molecular Testing for Mesenchymal Chondrosarcoma Test? (dovemed.com)
Biopsy4
- These were biopsy-proven dedifferentiated chondrosarcoma (Figure 3). (appliedradiology.com)
- Fine-needle aspiration of the mass (Figure 5) and subsequent biopsy (Figure 6) resulted in the pathologic diagnosis of dedifferentiated chondrosarcoma. (appliedradiology.com)
- In many chondrosarcoma cases, the tissue can be extracted with a needle, but if the chondrosarcoma is located centrally in the body, then the biopsy necessitates surgery. (knowcancer.com)
- Mesenchymal chondrosarcoma (MCS) is a rare subtype of CS that is more aggressive and may lead to erroneous diagnosis in a limited biopsy. (bmj.com)
Oncology10
- The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.The Chondrosarcoma (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Chondrosarcoma and features dormant and discontinued projects. (medindia.net)
- Similarly, the Universities portfolio in Phase I stages comprises 1 molecules, respectively.Chondrosarcoma (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (medindia.net)
- Scope - The pipeline guide provides a snapshot of the global therapeutic landscape of Chondrosarcoma (Oncology). (medindia.net)
- The pipeline guide reviews pipeline therapeutics for Chondrosarcoma (Oncology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (medindia.net)
- The pipeline guide reviews key companies involved in Chondrosarcoma (Oncology) therapeutics and enlists all their major and minor projects. (medindia.net)
- The pipeline guide evaluates Chondrosarcoma (Oncology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (medindia.net)
- The pipeline guide reviews latest news related to pipeline therapeutics for Chondrosarcoma (Oncology) Reasons to buy - Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies. (medindia.net)
- Find and recognize significant and varied types of therapeutics under development for Chondrosarcoma (Oncology). (medindia.net)
- Formulate corrective measures for pipeline projects by understanding Chondrosarcoma (Oncology) pipeline depth and focus of Indication therapeutics. (medindia.net)
- During our visit with Dr. Johnny Chretin , head of oncology at VCA Animal Hospital West Los Angeles Oncology Center , we wanted to know a little more about chondrosarcoma in dogs. (tripawds.com)
Subtype2
- Dedifferentiated chondrosarcoma occurs in approximately 11% of patients diagnosed with chondrosarcoma and is considered to be a histological subtype of this chondroid lesion. (appliedradiology.com)
- Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events. (lu.se)
Extraskeletal myxoid chondrosarcoma4
- The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. (nih.gov)
- The NR4A3 nuclear receptor is implicated in the development of extraskeletal myxoid chondrosarcoma (EMC), primitive sarcoma unrelated to conventional chondrosarcomas, through a specific fusion with EWSR1 resulting in an aberrant fusion protein that is thought to disrupt the transcriptional regulation of specific target genes. (nih.gov)
- Extraskeletal myxoid chondrosarcoma is a rare soft tissue sarcoma. (pubmedcentralcanada.ca)
- Here we report the case of a 15-year-old girl who presented with extraskeletal myxoid chondrosarcoma in the sacrococcygeal region which was regarded as unresectable. (pubmedcentralcanada.ca)
Peripheral6
- Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. (encyclopedia.com)
- Central chondrosarcoma occurs within a bone, and peripheral chondrosarcoma develops on the surface of a bone. (encyclopedia.com)
- Peripheral chondrosarcoma (PCS) remains a malignancy for which no treatments other than radical surgery have proven effective. (curesarcoma.org)
- We now report the first mouse genetic model of peripheral chondrosarcoma, which is completely penetrant. (curesarcoma.org)
- Although peripheral chondrosarcoma is far less common, many of the active signalling pathways in chondrosarcoma have been identified after the initial genetic event was elucidated. (sarcomahelp.org)
- We expected that we could further unravel the initiating event for enchondroma and central chondrosarcoma by studying Ollier disease as a model, similar to Multiple Osteochondromas elucidating many of the pathways involved in peripheral chondrosarcoma (Table 1). (sarcomahelp.org)
Cells27
- Chondrosarcomas arise from chondroblasts, cells that form cartilage. (encyclopedia.com)
- Most often, chondrosarcoma happens from normal cartilage cells. (hopkinsmedicine.org)
- The defining characteristic of a chondrosarcoma is that its cells produce cartilage. (mayoclinic.org)
- 1 The term "dedifferentiated" implies that a portion of cells from the chondrosarcoma have degenerated into a high-grade malignant form that is characterized by pleomorphism, anaplasia, hypercellularity, and increased mitoses. (appliedradiology.com)
- There is no report about the role of SIRT1 in the human chondrosarcoma cells. (nature.com)
- Both siRNA-SIRT1 transfection and MS-275 significantly inhibited the resveratrol-induced caspase-3 cleavage and activity in human chondrosarcoma cells. (nature.com)
- One possible explanation is that chondrosarcoma cells have lost their sense of direction. (curesarcoma.org)
- Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and "Chinese letter" shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia. (dovepress.com)
- Most often, chondrosarcoma starts in normal cartilage cells. (brighamandwomens.org)
- In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. (mdpi.com)
- The presence of CD99 positive spindle cells suggests mesenchymal chondrosarcoma . (radiopaedia.org)
- However, the amount of these spindled cells is small and not all the classic features of mesenchymal chondrosarcoma are seen on histology. (radiopaedia.org)
- By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. (lu.se)
- Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. (lu.se)
- the chondrosarcoma cells demonstrated a significant dose‑dependent increase in the expression levels of the DNA damage marker histone H2AX phosphorylation at serine 139 (γH2AX). (spandidos-publications.com)
- Comparative analyses of γH2AX at 1 and 24 h post‑IR revealed efficient DNA repair in human chondrosarcoma cells. (spandidos-publications.com)
- Therefore, additional bortezomib treatment may only temporarily improve the radiation sensitivity of chondrosarcoma cells. (spandidos-publications.com)
- In this study, we demonstrate that resistin enhances VEGF-C expression and lymphatic endothelial cells (LECs)-associated lymphangiogenesis in human chondrosarcoma cells. (ovid.com)
- The expression level of NAMPT and NAPRT transcripts in chondrosarcoma cells was determined by qRT-PCR. (aacrjournals.org)
- Chondrosarcoma cells showed a dose-dependent decrease in cell viability, 3D collagen invasion, and colony formation upon treatment with NAMPT inhibitors, in which nearly half of the cell lines demonstrated absolute IC 50 s in the low nanomolar range. (aacrjournals.org)
- We further demonstrated that adiponectin promoted VEGF-C expression and secretion in human chondrosarcoma cells. (clinsci.org)
- Following withdrawal of 5-aza-2-deoxycytidine, the rat chondrosarcoma cells reestablished global DNA methylation levels that were comparable to that of control cells. (luriechildrens.org)
- Concurrently, invasiveness of the rat chondrosarcoma cells, in vitro, decreased to a level indistinguishable to that of control cells. (luriechildrens.org)
- Taken together these experiments demonstrate that global DNA hypomethylation induced by 5-aza-2-deoxycytidine may promote specific aspects of tumorigenesis in rat chondrosarcoma cells. (luriechildrens.org)
- In addition, chondrosarcoma cells with an NRAS mutation were sensitive to treatment with a MEK inhibitor. (aacrjournals.org)
- Morphological changes during serial subculture of chondrosarcoma cells. (aacrjournals.org)
- Surprisingly, our investigations found that treatment of chondrosarcoma cells with S1P and transfecting them with SphK1 cDNA increased PDGF-A expression and induced angiogenesis of endothelial progenitor cells (EPCs). (aging-us.com)
Risk factors for chondrosarcoma2
- What are the risk factors for chondrosarcoma? (hopkinsmedicine.org)
- Talk with your healthcare provider about your risk factors for chondrosarcoma and what you can do about them. (brighamandwomens.org)
Base of th1
- Conformal proton beam radiation therapy or intensity-modulated radiation therapy (IMRT) may be used for chondrosarcoma tumours found at the base of the skull or in the spinal bones (vertebrae). (cancer.ca)
Cranial1
- Radiographic findings of 15 untreated chondrosarcomas of the cranial and facial bones were reviewed. (ajnr.org)
Diagnosis of mesenchymal1
- Molecular Testing for Mesenchymal Chondrosarcoma is a genetic test that is helpful in aiding a diagnosis of mesenchymal chondrosarcoma. (dovemed.com)
Skull base chondrosarcomas1
- 1 The authors showed, with a sample of 19 patients, that skull base chondrosarcomas could be differentiated from chordomas and from atypical chordomas by ADC values on diffusion-weighted MR imaging. (ajnr.org)
Aggressive3
- Treatment of chondrosarcoma in dogs must be aggressive. (vetinfo.com)
- Being aggressive and malignant in nature, chondrosarcomas of the larynx and trachea are usually life-threatening. (petmd.com)
- In type 1, the radiographic appearance is the same as for a central chondrosarcoma, with the addition of a region with very aggressive bone destruction. (atlasgeneticsoncology.org)
Spine3
- Strike SA, McCarthy EF (2011) Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. (springer.com)
- In cases where the chondrosarcoma affects the skull, spine, or chest cavity, a neurosurgeon or a thoracic surgeon usually performs the operation. (knowcancer.com)
- Mesenchymal chondrosarcoma has a predilection for the spine, ribs and jaw and it presents in the third decade. (bonetumor.org)
Tissue2
- However, chondrosarcoma forms in cartilage, the tough but flexible tissue that pads the ends of bones and lines joints, not in the bone tissue itself. (harvard.edu)
- Chondrosarcoma of the vertebrae leads to compression of the nervous tissue but there are no visible signs. (wearethecure.org)
Radiographic3
- Dedifferentiated chondrosarcoma: Radiographic features. (appliedradiology.com)
- Three radiographic types of dedifferentiated chondrosarcoma have been described. (atlasgeneticsoncology.org)
- Radiographic assessment of chondrosarcomas includes plain radiography of the entire bone involved. (cureus.com)
Radiation therapy4
- Chondrosarcomas have been observed as a late consequence of radiation therapy for other cancers. (hopkinsmedicine.org)
- External beam radiation therapy may be used to treat chondrosarcoma that can't be removed with surgery. (cancer.ca)
- Radiation therapy is also used for recurrent chondrosarcoma. (cancer.ca)
- Chondrosarcomas can be caused by radiation therapy used to treat other cancers. (brighamandwomens.org)