Chondrosarcoma: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)Chondrosarcoma, Mesenchymal: A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)Chondroma: A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Enchondromatosis: Benign growths of cartilage in the metaphyses of several bones.Chordoma: A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)Myxosarcoma: A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Femoral NeoplasmsSkull Base Neoplasms: Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).Exostoses, Multiple Hereditary: Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)Ribs: A set of twelve curved bones which connect to the vertebral column posteriorly, and terminate anteriorly as costal cartilage. Together, they form a protective cage around the internal thoracic organs.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Chondromatosis, Synovial: Rare, benign, chronic, progressive metaplasia in which cartilage is formed in the synovial membranes of joints, tendon sheaths, or bursae. Some of the metaplastic foci can become detached producing loose bodies. When the loose bodies undergo secondary calcification, the condition is called synovial osteochondromatosis.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Osteochondroma: A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.Maxillary Neoplasms: Cancer or tumors of the MAXILLA or upper jaw.

Analysis of acute vascular damage after photodynamic therapy using benzoporphyrin derivative (BPD). (1/542)

Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short times after injection of photosensitizer. Groups of rats with chondrosarcoma were given 2 mg kg(-1) of BPD intravenously 5 min to 180 min before light treatment of 150 J cm(-2) 690 nm. Vascular response was monitored using intravital microscopy and tumour cure was monitored by following regrowth over 42 days. For treatment at 5 or 30 min after BPD injection, blood flow stasis was limited to tumour microvasculature with lesser response in the surrounding normal microvasculature, indicating selective targeting for damage. No acute changes were observed in vessels when light was given 180 min after BPD injection. Tumour regression after light treatment occurred in all animals given PDT with BPD. Long-term tumour regression was greater in animals treated 5 min after BPD injection and least in animals given treatment 180 min after drug injection. The correlation between the timing for vascular damage and cure implies that blood flow stasis plays a significant role in PDT-induced tumour destruction.  (+info)

The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. (2/542)

The EWS/TEC gene fusion generated by the t(9;22) chromosomal translocation found in extraskeletal myxoid chondrosarcomas encodes a fusion protein containing the amino-terminal domain of the EWS protein fused to the whole coding sequence of the orphan nuclear receptor TEC. We have compared the DNA-binding and transcriptional activation properties of various TEC isoforms and the corresponding EWS/TEC fusion proteins. Band-shift experiments show that the full-length TEC receptor can efficiently bind the NGFI-B Response Element (NBRE), whereas an isoform lacking the entire carboxyl-terminal domain of the receptor binds much less efficiently the NBRE. Addition of the amino-terminal domain of EWS to either isoforms does not alter significantly their DNA-binding properties to the NBRE. Co-transfection experiments of COS cells and human chondrocytes indicate that whereas TEC moderately activates transcription from a NBRE-containing promoter, the corresponding EWS/TEC fusion protein is a highly potent transcriptional activator of the same promoter, being approximately 270-fold more active than the native receptor. EWS/TEC may thus exert its oncogenic potential in chrondrosarcomas by activating the transcription of target genes involved in cell proliferation.  (+info)

Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (3/542)

We report here the isolation and sulphation isomer analyses of trisaccharides GalNAcS(beta1,4)GlcA(beta1,3)GalNAcS (in which S indicates sulphate) derived from the non-reducing termini of aggrecan chondroitin sulphate. Rat chondrosarcoma and human aggrecans were digested for 1 h at 37 degrees C with 30 micro-units of endo-chondroitinase ABC per microgram of chondroitin sulphate, and trisaccharides were isolated from the digests by ToyoPearl HW40S gel-filtration chromatography. Four trisaccharide species were identified; their sulphation isomer compositions, as determined by digestion with chondroitinase ACII and fluorescence-based ion-exchange HPLC, were GalNAc4Sbeta1,4GlcAbeta1,3GalNAc4S, GalNAc4Sbeta1,4GlcAbeta1,3GalNAc6S, GalNAc4,6Sbeta1,4GlcAbeta1, 3GalNAc4S and GalNAc4,6Sbeta1,4GlcAbeta1,3GalNAc6S. The abundances of such sequences in chondroitin sulphate on aggrecan from normal (foetal to 72 years of age) and from osteoarthritic human knee cartilages were also established. The results showed that non-reducing terminal GalNAc4S or GalNAc4,6S can be linked to either a 4-sulphated or a 6-sulphated disaccharide, suggesting that the sulphation of the last disaccharide might not have a direct effect on the specificity of chondroitin sulphate terminal GalNAc sulphotransferases. Furthermore, for each aggrecan preparation examined, the 4S-to-6S ratio of all chain interior disaccharides was equivalent to that in the last repeating disaccharides at the non-reducing terminus, suggesting that neither chondroitin 4-sulphotransferase nor chondroitin 6-sulphotransferase shows preferential activity near the chain terminus.  (+info)

EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas. (4/542)

Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, have been cloned. It is still unclear whether osteochondroma is a developmental disorder or a true neoplasm. Furthermore, it is unclear whether inactivation of both alleles of an EXT gene, according to the tumor-suppressor model, is required for osteochondroma development, or whether a single EXT germline mutation acts in a dominant negative way. We therefore studied loss of heterozygosity and DNA ploidy in eight sporadic and six hereditary osteochondromas. EXT1- and EXT2-mutation analysis was performed in a total of 34 sporadic and hereditary osteochondromas and secondary peripheral chondrosarcomas. We demonstrated osteochondroma to be a true neoplasm, since aneuploidy was found in 4 of 10 osteochondromas. Furthermore, LOH was almost exclusively found at the EXT1 locus in 5 of 14 osteochondromas. Four novel constitutional cDNA alterations were detected in exon 1 of EXT1. Two patients with multiple osteochondromas demonstrated a germline mutation combined with loss of the remaining wild-type allele in three osteochondromas, indicating that, in cartilaginous cells of the growth plate, inactivation of both copies of the EXT1 gene is required for osteochondroma formation in hereditary cases. In contrast, no somatic EXT1 cDNA alterations were found in sporadic osteochondromas. No mutations were found in the EXT2 gene.  (+info)

Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. (5/542)

The sulfurylase domain of the mouse bifunctional enzyme ATP sulfurylase/adenosine 5'-phosphosulfate (APS) kinase contains HXXH and PP-loop motifs. To elucidate the functional importance of these motifs and of conserved arginines and histidines, chemical modification and site-directed mutagenesis studies were performed. Chemical modification of arginines and histidines with phenylglyoxal and diethyl pyrocarbonate, respectively, renders the enzyme inactive in sulfurylase, kinase, and overall assays. Data base searches and sequence comparison of bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number of highly conserved arginines and histidines within the sulfurylase domain. Of these conserved residues, His-425, His-428, and Arg-421 are present within or near the HXXH motif whereas His-506, Arg-510, and Arg-522 residues are present in and around the PP-loop. The functional role of these conserved residues was further studied by site-directed mutagenesis. In the HXXH motif, none of the alanine mutants (H425A, H428A, and R421A) had sulfurylase or overall activity, whereas they all exhibited normal kinase activity. A slight improvement in reverse sulfurylase activity (<10% residual activity) and complete restoration of forward sulfurylase was observed with R421K. Mutants designed to probe the PP-loop requirements included H506A, R510A, R522A, R522K, and D523A. Of these, R510A exhibited normal sulfurylase and kinase activity, R522A and R522K showed no sulfurylase activity, and H506A had normal sulfurylase activity but produced an effect on kinase activity (<10% residual activity). The single aspartate, D523A, which is part of the highly conserved GRD sequence of the PP-loop, affected both sulfurylase and kinase activity. This mutational analysis indicates that the HXXH motif plays a role only in the sulfurylase activity, whereas the PP-loop is involved in both sulfurylase and kinase activities. Residues specific for sulfurylase activity have also been distinguished from those involved in kinase activity.  (+info)

Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. (6/542)

OBJECTIVE: The aim of the study was to investigate the messenger RNA (mRNA) expression of the disintegrin metalloproteinase MDC15 (metargidin, or ADAM-15) in normal and osteoarthritic (OA) articular cartilage. METHODS: In situ hybridization experiments and reverse transcription-polymerase chain reaction (RT-PCR) were performed on tissue samples of adult normal and OA articular cartilage. RESULTS: MDC15 mRNA could be detected in normal articular cartilage by RT-PCR using tissue-extracted total RNA as a template. However, the mRNA level remained below the sensitivity of in situ hybridization. In contrast, in situ hybridizations of OA cartilage revealed an intense staining with the MDC15-specific riboprobes. The extension of the analysis to chondrosarcomas showed a strong up-regulation of MDC15 mRNA in these malignant transformed cells. CONCLUSION: Our results demonstrate a markedly strong up-regulation of MDC15 in adult OA and neoplastic cartilage compared with adult normal articular cartilage, indicating a potential role of the disintegrin metalloproteinase in cartilage remodeling.  (+info)

Reconstruction and limb salvage after resection for malignant bone tumour of the proximal humerus. A sling procedure using a free vascularised fibular graft. (7/542)

We assessed the intermediate functional results of eight patients after wide resection of the proximal humerus for malignant bone tumour. We used a free vascularised fibular graft as a functional spacer and a sling procedure to preserve passive scapulohumeral movement. Scapulohumeral arthrodesis was not carried out. Five patients had osteosarcoma, two achondrosarcoma and one a malignant fibrous histiocytoma of the bone. The mean duration of follow-up was 70 months (median, 76) for the seven patients who were still alive at the time of the latest follow-up. One patient died from the disease 12 months after surgery. There were no local recurrences. The functional results were described and graded quantitatively according to the rating system of the Musculoskeletal Tumour Society. Our results were satisfactory with regard to pain, emotional acceptance and manual dexterity. Function and lifting ability were unsatisfactory in two patients. One patient had delayed union between host and graft, but this united after six months without further surgery. Radiographs of the shoulder showed absorption or collapse of the head of the fibula in four of the eight patients and a fracture in another. No functional problems related to absorption or fracture of the head of the fibula were noted. There was no infection or subluxation of the head. We conclude that this is a reasonably effective technique of limb salvage after resection of the proximal humerus.  (+info)

Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. (8/542)

Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. Here we report that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC. Two tumors, one with a novel t(9;17)(q22;q11) variant translocation and one with an apparently normal karyotype, expressed TAF2N-TEC fusion transcripts. In both cases, the chimeric transcripts were shown to contain exon 6 of TAF2N fused to the entire coding region of TEC. This transcript is structurally and functionally very similar to the EWS-TEC fusions. The exchange of the EWS NH2-terminal part with the TAF2N NH2-terminal part in EMC further underscores the oncogenic potential of these protein domains as partners in fusion genes.  (+info)

*Chondroblast

Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. ... unreliable medical source?] Aufderheide, A.C.; Rodríguez-Martín, C.; Langsjoen, O. (2011). "Chondrosarcoma". The Cambridge ...

*List of OMIM disorder codes

GDF5 Chondrosarcoma; 215300; EXT1 Chondrosarcoma, extraskeletal myxoid; 612237; TAF15 Chondrosarcoma, extraskeletal myxoid; ... 612237; TFG Chondrosarcoma, extraskeletal myxoid; 612237; CSMF Chorea, hereditary benign; 118700; NKX2-1 Choreoacanthocytosis; ...

*BRICHOS family

... related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress ...

*Russell Blaylock

Russell L. Blaylock; Ludwig G. Kempe (April 1976). "Chondrosarcoma of the cervical spine". 44 (4). The Journal of Neurosurgery ...

*Synovial osteochondromatosis

Malignant transformation to synovial chondrosarcoma. This is a very rare complication occurring in chronic cases. Treatment ... Synovial chondrosarcoma Other: Osteochondritis dissecans Sequestrum from osteomyelitis Neuropathic (Charcot) joint Intra- ...

*Alan L. Schiller

Coltrera MD, Googe PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML (1986). "Chondrosarcoma of the temporal bone. Diagnosis ...

*Chordoma

"Chordoma and chondrosarcoma gene profile: implications for immunotherapy". Cancer Immunology and Immunotherapy. 58 (3): 339-49 ... Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. Chordomas can arise from bone in the ...

*Hereditary multiple exostoses

A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems ... Kivioja A, Ervasti H, Kinnunen J, Kaitila I, Wolf M, Böhling T (March 2000). "Chondrosarcoma in a family with multiple ...

*Cartilage tumor

They can be either benign (Chondroma) or malignant (chondrosarcoma). Frequently these tumors appear in bone, and not in pre- ...

*William DeVries

" "Chondrosarcoma Masquerading as Cardiomyopathy" ; Charles R. Mulligan, Jr, Houman Tavaf-Motamen, Robert Stewart, and William ...

*Kostniakomięsak, wolna encyklopedia

Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. „Clin Orthop Relat Res". 459, s. 40-7, Jun ... Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.. „Med Sci Monit". 17 (8), s. RA177-190 ...

*IFFO1

However, the gene has been found to be highly expressed in chondrosarcoma. Chondrosarcoma is the cancer of the cells that ... Therefore, there seems to be an association between IFFO1's filamentous characteristic and chondrosarcoma. One nuclear export ...

*The Myriad

Drummer Randy Miller died from chondrosarcoma on November 5, 2010. The family set up a place for people to donate money to his ...

*Black-necked spitting cobra

B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-1607. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda ...

*Tenascin C

... is implicated in a number of different cancers such as osteosarcomas, chondrosarcomas, bladder cancer, and ... "The clinical significance of tenascin-C splice variant expression in chondrosarcoma". Oncology. 61 (4): 306-14. doi:10.1159/ ...

*List of dangerous snakes

B16F10 and chondrosarcoma". Life Sciences. 40 (16): 1601-7. doi:10.1016/0024-3205(87)90126-3. PMID 3561167. Fryklund, Linda; ...

*LECT1

"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its ... "Expression of the chondromodulin-I gene in chondrosarcomas". Cancer Letters. 204 (1): 61-8. doi:10.1016/j.canlet.2003.09.015. ...

*Vaccine-associated sarcoma

Fibrosarcoma is the most common VAS; other types include rhabdomyosarcoma, myxosarcoma, chondrosarcoma, malignant fibrous ...

*Temporomandibular joint

These conditions include chondrosarcoma, osteosarcoma, giant cell tumor and aneurysmal bone cyst. The temporomandibular joints ...

*Polysomy

Abnormalities of chromosome 13 have been observed in canine osteoid chondrosarcoma and lymphosarcoma. Trisomy 13 in dogs with ...

*Chandler Park

C. Park, A. Husain "PET scan negative metastatic chondrosarcoma," American College of Physicians. Research Presentation. ...

*Bone tumor

Malignant primary bone tumors include osteosarcoma, chondrosarcoma, Ewing's sarcoma, fibrosarcoma, and other types. While ... such as chondrosarcoma). There is a variety of chemotherapy treatment protocols for bone tumors. The protocol with the best ...

*Bone metastasis

Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing's sarcoma are rare. Unlike hematological ...

*C8orf46

These disease states include chondrosarcoma, glioma, kidney tumors, liver tumors, and germ cell tumors. C8orf46 is only ...

*Aneurysmal bone cyst

Less frequently, it results from some malignant tumors, such as osteosarcoma, chondrosarcoma, and hemangioendothelioma. ...

*Osteochondroma

In large, secondary chondrosarcoma arises at the site of osteochondroma due to increased thickness of the cartilage cap ... Tests for osteochondroma can also identify diseases such as secondary peripheral chondrosarcoma and Multiple ...
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of αvβ3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated that IL-8 enhances the migration of chondrosarcoma cells by increasing αvβ3 integrin ...
article{52f6a2c0-7074-42f4-ae84-0c0dbf6711b3, abstract = {,p,Rat chondrosarcoma chondrocytes were labeled with [,sup,3,/sup,H]serine or [,sup,3,/sup,H]mannose as a precursor. Intracellular proteoglycan core protein precursor was purified from cell lysates by immunoprecipitation with polyclonal antibodies against the hyaluronic acid-binding region, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The core precursor was eluted from the gels and treated with alkaline borohydride in order to convert serine residues substituted with xylose or N-acetylgalactosamine to alanine (or with alkaline sulfite to convert them to cysteic acid). After acid hydrolysis, the proportions of labeled serine and alanine (or cysteic acid) were determined by high performance liquid chromatography, and the results were compared with those obtained for the completed proteoglycan molecules isolated from the same cultures. In the completed proteoglycans, about 55% of the serine residues were substituted ...
OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and 11 and matrix metalloproteinases (MMP)-1, 3, and 13, and their tissue inhibitor TIMP-1, depends on the transcription factor nuclear factor-kappaB (NF-kappaB). METHODS: Fibroblasts and chondrosarcoma cells were effectively infected with an adenovirus encoding human IkappaBalpha, and inhibition of NF-kappaB function was observed. The induction of MMP and IL-6, 8, and 11 by various stimuli was assessed by ELISA. RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, irrespective of stimulus, but IkappaBalpha overexpression had little effect on IL-11. MMP-1, -3, and -13 were also inhibited, but TIMP-1 was unaffected. CONCLUSION: NF-kappaB appears to play an important and selective role in MMP induction in human fibroblasts and chondrosarcoma cells. This suggests there are NF-kappaB dependent mechanisms of cartilage ...
55 year old male with dedifferentiated chondrosarcoma and pathological fracture. Final Diagnosis: Left proximal femur and soft tissues, en bloc excision: Dedifferentiated chondrosarcoma High grade, grade 3/3 Maximum size 14.6 cm Tumor is ba...
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that over-expression of COX-2 or exogenous PGE2 increased the migration of human chondrosarcoma cells. We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was higher than that in normal cartilage. By using pharmacological inhibitors or activators or genetic inhibition by the EP receptors, we discovered that the EP1 receptor but not other PGE receptors is involved in PGE2-mediated cell migration and α2β1 integrin expression. Furthermore, we found that human
Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance do not reliably predict the risk of local recurrence and metastases, making selection of surgical treatment difficult. Identifying mechanisms responsible for the proliferation and invasive behavior of these tumors would be of immense clinical value. We hypothesized that telomerase expression is one of these mechanisms. We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas acquired strong telomerase activity and lost tumor suppressor activity after their establishment in culture. These changes were associated with accelerated indefinite cell proliferation, morphological transition, and increased invasive activity, indicating that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from chondrosarcoma cell populations. These observations may lead to better ...
In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes. BPB induced upregulation of Bax, Bad and Bak, downregulation of Bcl-2, Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and Endo G. Furthermore, it triggered extrinsic death receptor-dependent pathway, which was characterized by activating Fas, FADD and caspase-8. Most importantly, animal studies revealed a dramatic 40% reduction in tumor volume after 21 days of treatment. Thus, BPB may be a novel anticancer agent for the treatment of chondrosarcoma.
BioAssay record AID 79237 submitted by ChEMBL: In vitro cytotoxicity in chondrosarcoma cell line (H-EMC-SS) by Alamar blue assay.
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. To achieve a greater understanding of chondrosarcoma tumorigenesis, a model for human chondrosarcoma has been established in a rat system. The model, known as the Swarm rat chondrosarcoma (SRC), resembles human chondrosarcoma and provides a system to study tumor growth and progression. Here we examined the influence of the tumor microenvironment and the impact of genome-wide hypomethylation on the behavior of SRC tumors, two factors known to contribute fundamentally to the development and progression of solid tumors. Previous studies with SRC revealed that tumor microenvironment can significantly influence chondrosarcoma malignancy, but the underlying biologic mechanisms have not been defined. To address this issue we carried out epigenetic and gene expression studies on the SRC tumors that were initiated at
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
... , Authors: Andreas F Mavrogenis, Panayiotis J Papagelopoulos. Published in: Atlas Genet Cytogenet Oncol Haematol.
Primary chondrosarcoma of the breast, although very rare, has been reported previously.1 An extensive review of 132 636 cases of breast cancer between 1973 and 1998, in the Netherlands,2 identified 34 cases of concurrent breast cancer and cartilaginous tumours. There were 28 osteochondromas in the same group as well but a statistically similar incidence of concurrent osteochondromas was observed in patients with lung cancer. Out of the 34 cases, 18 were enchondromas and 15 chondrosarcomas, and involved mostly the femur or humerus (65%). All 34 had histological and immunohistochemical survey performed and cluster analysis did not reveal any associations with known syndromes or genetic traits. Their findings support the existence of a new hitherto unrecognised syndrome, characterised by an increased risk to develop breast cancer and also centrally originating cartilaginous tumours. There have been sporadic reports of concurrent breast carcinoma as well as bone chondrosarcoma in the literature.3 ...
Imaging studies - including radiographs ("x-rays"), computerized tomography (CT), and magnetic resonance imaging (MRI) - are often used to make a presumptive diagnosis of chondrosarcoma. However, a definitive diagnosis depends on the identification of malignant cancer cells producing cartilage in a biopsy specimen that has been examined by a pathologist. In a few cases, usually of highly anaplastic tumors, immunohistochemistry (IHC)is required.. There are no blood tests currently available to enable an oncologist to render a diagnosis of chondrosarcoma. The most characteristic imaging findings are usually obtained with CT.. Nearly all chondrosarcoma patients appear to be in good health. Often, patients are not aware of the growing tumor until there is a noticeable lump or pain. Earlier diagnosis is generally accidental, when a patient undergoes testing for another problem and physicians discover the cancer. Occasionally the first symptom will be a broken bone at the cancerous site. Any broken ...
Chondrosarcomas are a primitive malignant tumor that derives from cartilage cells. It usually appears at the center of a bone segment, with no pre-existing lesions (central chondrosarcoma). It may also be secondary to a pre-existent condition suc...
Gentaur molecular products has all kinds of products like :search , US Biomax \ Osteosarcoma and chondrosarcoma tissue array, with stage, grade and TNM data, 80 cases_80 cores, replacing OS801 and BC26111; ihc Anti-Actin confirmed \ OS802 for more molecular products just contact us
We report an unusual case of a young woman with chondrosarcoma affecting the greater cornu of the hyoid bone. Only a handful of reports of primary chondrosarcoma involving the hyoid exist in the world literature. The case described presented as a swe
As for the genetics and causes of the cancer, it has been rather hard to find sources which can determine the cause of it, from the website…. The genetic changes specific to chondrosarcoma continue to be investigated extensively. Although studies have not yet established a specific or recurrent karyotypic feature for any of these tumors, different chondrosarcomas have demonstrated anomalies in several tumor suppressor genes, oncogenes, and transcription factors, including TP53, RAS, EXT1, EXT2, and Sox9. Available cytogenetic and comparative genomic hybridization (CGH) studies reveal changes in some chondrosarcomas, but fail to do so in others. These studies are thus far difficult to interpret.. Based on the available studies, it is likely that chondrosarcomas are generated by a coordinated, multi-step process involving primarily tumor suppressor genes. In fact, the complexity and variety of genetic changes seen in chondrosarcomas may indicate several distinct genetic pathways. Some of the ...
Sarcoma is a peer-reviewed, Open Access journal dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposis sarcoma, are published as well as preclinical and animal studies.
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
Chondrosarcoma is a type of cancer that develops in cartilage cells. Cartilage is the specialized, gristly connective tissue that is present in adults and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondrosarcoma is a malignant type of bone cancer that primarily affects the cartilage cells of the femur (thighbone), arm, pelvis, and knee. Although less frequent, other areas (such as the ribs) may be affected.. Chondrosarcoma is the second most common type of primary bone cancer. A primary bone cancer is one that originates from bone, as opposed to starting in another organ and then spreading to the bone. This type of cancer rarely affects individuals under age 20 and continues to rise until age 75. The incidence between males and females is equal.. ...
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A case of an entirely intramuscular mixed tumour occurred in an 82-year-old man, who presented with a large mass in the region of the right triceps muscle. A lobulated tumour was seen, with plump, round epithelioid cells embedded in a chondromyxoid stroma. Immunohistochemical examination showed strong S100 protein and pancytokeratin positivity in most of the tumour cells. Cytogenetic analysis revealed complex clonal chromosomal changes: 47, XY, +i(2) (q10), -15, der(17) t(15; 17) (q11; p12), +r. Differential diagnosis against extraskeletal myxoid chondrosarcoma (EMC) may be problematic, particularly in an incisional biopsy. Chromosomal analysis can be very helpful in solving this problem, since EMC shows a specific reciprocal chromosome translocation characterised as t (9;22) (q22-31) (q11-12 ...
Chondrosarcoma is categorized as a malignant cartilaginous tumor, which occurs rarely in the craniofacial region. We report the case of a 68-year-old man with chondrosarcoma in the subglottic area. His chief symptoms were hoarseness and mild dysphagi
Purpose: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents. We sought to identify critical signaling pathways that contribute to their survival and proliferation, and which may provide potential targets for rational therapeutic interventions. Experimental Design: Activation of receptor tyrosine kinases (RTKs) was surveyed using phospho-RTK arrays. S6 phosphorylation and NRAS mutational status were examined in chondrosarcoma primary tumor tissues. Small interfering RNA or small molecule inhibitors against RTKs or downstream signaling proteins were applied to chondrosarcoma cells and changes in biochemical signaling, cell cycle, and cell viability were determined. In vivo anti-tumor activity of BEZ235, a phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor, was evaluated in a chondrosarcoma xenograft model. Results: Several RTKs were identified as critical mediators of cell growth, but the RTK dependencies varied among cell lines. In ...
Although a rare entity, chondrosarcoma is the most common malignant tumor of the chest wall. Most patients present with an enlarging, painful anterior chest wall mass arising from the costochondrosternal junction. CT scan with intravenous contrast is the gold standard radiographic study for diagnosis and operative planning. Contrary to previous dictum, resection may be performed in an appropriate surgical candidate based on imaging characteristics or image-guided percutaneous biopsy results; incisional biopsy is rarely required. The keys to successful treatment are early recognition and radical excision with adequate margins, as chondrosarcoma is relatively resistant to radiotherapy and conventional cytotoxic chemotherapy. Overall survival is excellent in most surgical series from experienced centers. Complete excision with widely negative microscopic margins at the initial operation is of the utmost importance, as local recurrence portends systemic metastasis and eventual tumor-related mortality. This
Clear-cell chondrosarcoma is a variant of chondrosarcoma which is characterized by a typical histomorphology and a very slow rate of growth. A case is presented in which the tumor was located in the maxilla. show less ...
Answer: Chondrosarcoma. Histology: none provided. Discussion: Chondrosarcomas are malignant proliferations of cartilage which tend to occur in the axial skeleton of older people. The radiograph in this case is helpful to diagnose a malignant tumor because of its destructive and aggressive permeative pattern. Histologically the cartilage shows atypical nuclei and a permeative growth pattern around native trabeculae. This permeative growth pattern is diagnostic of malignancy in most primary bone tumors. The radiograph, however, is a most important tool leading to the diagnosis of chondrosarcoma.. Although metastatic carcinoma is the most common bone tumor in this age group, there is no evidence of epithelial cells in this case.. Enchondromas occasionally occur in the pelvis. Occasionally, the cartilage of enchondroma can show atypia. However, the destructive and aggressive radiographic pattern precludes the diagnosis of an enchondroma. Therefore, the radiograph should always be consulted when ...
Chondrosarcomas are characteristic for their slow but progressive invasion of the surrounding tissues. These malignant, cancerous tumors originate in the cartilage, the connective tissue between bones.
Depending on the type of chondrosarcoma, it may spread slowly or very rapidly. Its presently unknown what causes this type of cancer. This is partially because it is so unusual that there are not a lot of cases to study. A higher incidence of nasal CSAs among cats living in urban areas may indicate a link to air pollution. The type affecting bones has been found to contain viruses in the cells of the tumor, suggesting a viral connection. Some bone tumors develop on the site of a previous fracture, which may mean theres a link with the bodys cells that heal a broken bone. But its believed that several factors combine with each unique cats physiology to cause the cells to become cancerous ...
A chondrosarcoma is one of several types of laryngeal tumors that can effect the larynx and trachea of a dog. This is a relatively rare and fast spreading tumor that originates in the cartilage, a connective collagenous tissue that is found throughout the body.
... is a malignant type of bone cancer that primarily affects the cartilage cells of the femur, arm, pelvis, knee, and spine.
Chondrosarcoma treatments include chemotherapy, radiation therapy, targeted therapies, and surgery, to remove the mass and reduce the likelihood of return.
Learn more about Chondrosarcoma at Coliseum Health System DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision .....
Selenium (Se) is an essential trace element and metalloid involved in several key metabolic activities: protection against oxidative damage, regulation of immune and thyroid function, and fertility. Several recent lines of evidence from epidemiology, genetic, and transgenic animal studies suggest that Se may play a protective role in Osteoarthritis (OA). However, the exact protective mechanism of Se is still unclear. In this study, we hypothesized that Se exerts its chondroprotective benefit via an anti-oxidative and anti-inflammatory effect mediated by specific selenoproteins that neutralize cytokine-induced inflammatory responses in chondrocytes. We established an in vitro system for studying the effect of Se in the chondrosarcoma cell line SW-1353 and in human primary chondrocytes. Selenomethionine (SeMet) induced gene expression and enzyme activity of both antioxidative enzymes glutathione peroxidase (GPX) and thioredoxin reductase (TR) in SW-1353 cells. Our data suggest that Se may be ...
The Anti-Cancer Effect of a Novel Nutrient Mixture by Inhibiting MMPs Expression, Invasion and Inducing Apoptosis in Chondrosarcoma Cell Line SW-1353
The study, "Lost miRNA surveillance of Notch, IGFR pathway - road to sarcomagenesis," was published in the January issue of Tumor Biology, the official journal of the International Society of Oncology and BioMarkers. Sarcomas are a group that makes up more than 60 different tumors that affect bone and connective tissues. Chondrosarcomas are the second most common bone malignancy and do not respond to conventional therapy. Together with H. Thomas Temple, M.D., professor and Vice Chair of Orthopedics and Director of the Tissue Bank, who in 2010 established the Musculoskeletal Oncology Signal Transduction Laboratory to investigate the molecular pathways leading to metastatic sarcomas, Galoian and her team compared and analyzed differentially expressed miRNA and their targets in chondrosarcoma versus control chondrocytes. "Under normal conditions, mesenchymal cells support and produce a matrix for connective tissues; however, the signaling events resulting in mesenchymal cell transformation to ...
It was a Saturday, about tea-time in the quaint village of Athelstaneford, East Lothian. Mrs Alexandria Agutter sat in her cottage, enjoying the delights of the late-summer evening with a glass of gin and tonic. She listlessly sipped from the rather generous pick-me up, no doubt chewing over the happenings of the day. Blast! The taste was much too bitter to her liking. She stood up. And promptly crumpled to the floor in a dizzied heap. It had not been five minutes when a fiery pain gripped her parched throat and in her frenzied turn she watched the bleary room become draped in a gossamery silk. How Dame Agatha would approve. But this is no crime novel, on that fateful day, 24th August 1994, poor Mrs Agutter immortalised herself in the history books of forensic medicine; she was the victim of a revered toxin and a vintage one it was too. She had unwittingly imbibed a G&T laced with a classic poison of antiquity. A clue from the 21st century: do you recall the first Hunger Games film adaption? ...
Axial T2 weighted MR image again demonstrates the mass with typical high signal lobular growth pattern of cartilage representing cap.
Marco wants to wait at least 8 weeks to let everything heal up and also allow us time to decide where to go from here. My initial feelings lean toward the complete knee replacement. The other concern is of the cancer spreading to the lungs. I had a c.t. scan before surgery that revealed no tumors in the lungs. However, the cancer is slow-growing so it could already be there and just not visible. I will continually have c.t. scans to check That is our update. Please continue to pray for Jenny as she is due with our second baby in less than 1 month. Also pray for Zeke as he is in the difficult transition from only child to soon to be little brother (which is only complicated with all the added stress of my medical conditions ...
When I was diagnosed with ovarian cancer, the first reaction was of course panic, and then I Packed up and started to look for information on the Internet and on the forums. Im still grateful to all those people who write reviews about their appeal to different professionals - I this information helped to survive. That is why I write about how I got to Israel, and how I was able to overcome the disease.The purpose of my search information on the Internet to understand where and how to treat ovarian cancer, what are my prospects in General? The important thing is that I knew we must act quickly. Of course, I wanted to go to a top specialist because of the ability to experiment just wasnt there.I immediately realized that I wanted to be treated in Israel, as there is a percentage of cure from cancer is very high, including ovarian cancer. This treatment is cheaper than, say, the USA or Germany, for me it was also an important argument. I only had to choose the doctor. About Professor Moshe Inbar ...
Chondrosarcoma of the pelvis and upper end of the femur. An analysis of factors influencing survival time in one hundred and thirteen cases. Journal of Bone and Joint Surgery - American Volume. 1972 ...
Farese, JP, Kirpensteijn, J, Kik, M, Bacon, NJ, Waltman, SS, Seguin, B, Kent, M, Liptak, J, Straw, R, Chang, MN, Jiang, Y and Withrow, SJ (2009) Biologic Behavior and Clinical Outcome of 25 Dogs with Canine Appendicular Chondrosarcoma Treated by Amputation: A Veterinary Society of Surgical Oncology Retrospective Study ...
We were delayed in finding these spots because some misogynistic prick of a hip doctor tried to convince her that the pain was just mental and contrived. No, I didnt punch him. I was kind of in shock when he said it and missed my opportunity. I figured if I went back to physically harm this jerk, it would no longer be a defensible crime. So we might try for this guys medical license and hit him where it really hurts. Hell in this Trump era of politics, we might be able to send that guy back to Iran. I kid, I kid. Anyways, if you can relay a request or two for us and ask God to covet the minds and souls of the new team of doctors, that would be appreciated. We just met them at your old stomping grounds at Hopkins. Boy, did that bring back memories. After our first consult/meeting, we have decided they will assume all her care with regards to this hip/spine/leg/chondrosarcoma stuff. Still, no definitive answers without more tests. So we wait for pre-authorization from insurance. If the insurance ...
The actuarial 5- and 10-year survival rates after GKS were 80 and 53%, respectively. The actuarial 5- and 10-year local tumor control (LTC) rates after single or multiple GKS sessions were 76 and 67%, respectively. All patients with low-grade chondrosarcomas achieved good LTC. A tumor volume of less than 20 ml significantly affected the high rate of LTC (p = 0.0182). No patient had adverse radiation effects, other than one in whom facial numbness worsened despite successful tumor control. ...
(2009) Kim et al. Molecular Cancer. Background: High expression of P-glycoprotein is one of the well-known mechanisms of chemoresistance in chondrosarcomas. However, the role of antiapoptotic proteins, a common mechanism responsible for chemoresistance in other tumors, has not been well studied i...
Myxofibrosarcoma (MFS) is characterized by abundant myxoid stroma, a wide spectrum of cytological atypia, and frequent local recurrence. Some soft tissue tumors with myxoid stroma can histologically mimic MFS, but have different biological behaviors. Here we sought to identify a useful diagnostic marker for MFS. After our analysis of the gene expression dataset from the Gene Expression Omnibus database, we focused on claudin 6 (CLDN 6). The status of CLDN 6 was assessed by immunohistochemistry in 61 samples of MFS and other (benign) myxoid soft tissue tumors (28 myxoma samples, 12 nodular fasciitis samples), 18 low-grade fibromyxoid sarcoma, 30 myxoid liposarcoma, 29 extraskeletal myxoid chondrosarcoma and 27 dedifferentiated liposarcoma with myxoid feature samples ...
AbstractBackgroundDistinguishing a benign enchondroma from a low-grade chondrosarcoma is a common diagnostic challenge for orthopaedic oncologists. Low interrater agreement has been observed for the diagnosis of cartilaginous neoplasms among radiologists and pathologists, but, to our knowledge, no s
Twenty-eight patients with histologically confirmed chordomas (18) or chondrosarcomas (10) underwent Gamma Knife SRS either as primary or adjuvant treatment. Their ages ranged from 17 to 72 years (median 44 years). The most common presenting symptom was diplopia (26 patients, 93%). In two patients, SRS was the sole treatment. Twenty-six patients underwent between one and five additional surgical procedures. Two underwent an initial trans-sphenoidal biopsy. The average tumor volume was 9.8 cm3. The median dose to the tumor margin was 16 Gy. ...
Published papers: 1. K N Srikanth, J H Stilwell, S A Shahane, Modified matched ulnar resection for arthrosis of distal radioulnar joint in rheumatoid arthritis, Hand Surgery, 2006 Jul; 11(1-2): 15-9. PMID:17080523 2. K N Srikanth, M Chong, K Porter. Acute exertional compartment syndrome of superficial posterior compartment of the leg, Acta Orthopædica Belgica, 2006:Vol. 72 -4:507-510. 3. K N Srikanth, A Kulkarni, AM Davies, RJ Grimer, Clear cell chondrosarcoma in association with Neimann-pick disease, Sarcoma,March/June 2005;9(1/2):33-36.A Gadgil, R Dias, 4. K.N. Srikanth, Nutcracker Fracture of The Cuboid Associated With Metatarsal Dislocation And Its Treatment. The Internet Journal of Orthopedic Surgery. 2006. Volume 3 Number 1. 5. Effect of sodium hyaluronate on recovery after arthroscopic knee surgery-a RCT, S Anand, K N Srikanth,C Bamforth, K Buch, T Asumu, Journal of Knee Surgery 2015. ...
MULLER, Daniel Curvello de Mendonça et al. Hemipelvectomy in the treatment of chondrosarcoma of the acetabulum dog. Cienc. Rural [online]. 2010, vol.40, n.5, pp.1218-1222. ISSN 1678-4596. http://dx.doi.org/10.1590/S0103-84782010000500036.. Hemipelvectomy is the removal of part of the pelvis and is indicated for the surgical treatment of malignant tumors. This study presents the case of a canine patient with recurrent chondrosarcoma, submitted to hemipelvectomy with limb amputation. The report aims to highlight the importance of surgery in the treatment of radial bone chondrosarcoma, addressing a viable and unconventional alternative for patients suffering from tumors in the pelvis, which against the extension of the lesion may be misdiagnosed as intractable cancer. After the partial hemipelvectomy with amputation of the limb the animal satisfactory returned to ambulation without difficulty in supporting or alteration in balance.. Keywords : neoplasm; pelvis; cancer surgery; dogs. ...
Pain is the usual presenting symptom; alternatively the tumour may be found incidentally on imaging. Signs are localise to the involved bone. Imaging appearances are difficult as most chondrosarcomas resemble benign chondroma. The most common features are of central lucency with expansion and thickening of the overlying cortex.. ...
Chondroid tumors are predominantly lesions of the axial skeleton but can infrequently have an extraskeletal origin. Primary intracranial chondrosarcomas constitute ,0.16% of all brain tumors, an overwhelming majority of which are skull base tumors (1, 2). They are thought to arise from undifferentiated cells from cartilaginous synchondroses (1-3, 6, 7). Much less common sites include the falx, choroid plexus, and convexity. The histogenesis at this site is uncertain but is thought to arise from the pluripotent cells of the meninges.. Primary chondrosarcomas can be classified as mesenchymal, myxoid, or classical based on their cytoarchitecture. In the series published by Korten et al (2), which included 15 case reports plus 177 cases from a review of the literature, no sex dominance was shown. Ages varied from 3 months to 76 years, with a mean age of 37 years. Considering the rarity of occurrence of intracranial chondrosarcomas, it was difficult to establish a clear demographic pattern; however, ...
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been shown to contribute directly to tumour formation, migration and invasion. However, little is known about the molecular basis for its role in development and oncogenesis because there is a paucity of information regarding its target genes. The cyclin-dependent kinase inhibitor p21WAF1 plays a pivotal role in a myriad of processes including cell cycle arrest, senescence and apoptosis and here we provide a detailed mechanism to show that it is a direct and biologically relevant target of TBX3. Using a combination of luciferase reporter gene assays and in vitro and in vivo binding assays we show that TBX3 directly represses the p21WAF1 promoter by binding a T-element close to its initiator. Furthermore, we show that the TBX3 DNA binding domain is required for the transcriptional repression of p21WAF1
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better ...
... , long-time bassist of The Icarus Line, has died. He had been battling a rare form of cancer (mesenchymal chondrosarcoma), and finally lost the fight a few hours ago. As someone who has met him several times over the years, I am genuinely saddened by his passing. He was a "cool dude". May you […]. ...
Detailed information on bone cancers, including chondrosarcoma, ewings sarcoma, myeloma bone disease, multiple myeloma, and osteosarcoma
One of the more confusing times in an oncology examination room is describing what a round cell tumor is to a pet owner. The term is broad and describes myriad tumors that appear cytologically or histologically as a monotonous population of undifferentiated cells with high nuclear to cytoplasmic ratios. In dogs, this group includes mesenchymal and epithelial tumors as osteosarcoma, rhabdomyosarcoma, certain melanomas, chondrosarcoma, and basal cell tumors. However, the ultimate …
Colorectal plasmocytomas are uncommon neoplasias. But when they occur, it is impotant to know how to treat them best: Just wait and see? Do a normal resection or a resection with wide margins which is very difficult in this region? A very informative recently published study.
An enchondroma is a cartilage cyst found in the bone marrow. Typically, enchondroma is discovered on an X-ray scan. Enchondromas have a characteristic appearance on Magnetic Resonance Imaging (MRI) as well. They have also been reported to cause increased uptake on PET examination. Enchondroma is a type of benign bone tumor that originates from cartilage. The exact etiology of it is not known. An enchondroma most often affects the cartilage that lines the inside of the bones. The bones most often involved with this benign tumor are the miniature long bones of the hands and feet. It may, however, also involve other bones such as the femur, humerus, or tibia. While it may affect an individual at any age, it is most common in adulthood. The occurrence between males and females is equal. It is not very likely that the enchondroma will grow back in the same spot; the rate is less than ten percent. While the exact cause of enchondroma is not known, it is believed to occur either as an overgrowth of the ...
Chordomas and chondrosarcomas are difficult to manage using conventional cancer treatment methods. Areas of the body frequently affected by this type of cancer include the spine, skull, pelvis, hip, and shoulder.. Effective treatment of these tumours using surgical resection is not usually achievable due to neurovascular involvement. As a result, recurrence of the tumour when surgery is used in isolation poses a significant risk for both chordomas and chondrosarcomas. Due to the low risk of metastasis and relative chemoresistance, the use of definitive radiotherapy or perioperative radiotherapy is very important in maintaining local control.. Previous research has shown proton therapy to be beneficial in treating these types of tumours. Using protons, health professionals are able to treat chordoma and chondrosarcoma with higher doses of radiation due to the increased accuracy of proton therapy.. A 2019 study published in the journal Cancer entitled: The role of dose escalation and proton ...
NIH Rare Diseases : 50 ollier disease is a skeletal disorder characterized by multiple enchondromas, which are noncancerous (benign) growths of cartilage that develop within the bones. these growths may lead to skeletal deformities, limb discrepancy, and fractures. the enchondromas primarily occur in the limb bones, especially the bones of the hands and feet. they tend to develop near the ends of the bones, where growth occurs. symptoms often appear in the first decade of life. the underlying cause of ollier disease is not fully understood. in many people, the condition can be attributed to somatic mutations in the idh1 or idh2 gene. the disease is not typically inherited. treatment is conservative in most cases, although surgery may be indicated in cases where complications (pathological fractures, growth defects, malignant transformation) arise. last updated: 12/12/2016 ...
Ollier disease is a rare nonhereditary disorder characterized by cartilage cysts found in the bone marrow. It is also known as enchondromatosis.
Sarcoma is a peer-reviewed, Open Access journal dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposis sarcoma, are published as well as preclinical and animal studies.
An adult male squirrel monkey with severe bilateral exophthalmia and conjunctivitis was euthanatized. Necropsy revealed, in a sagittal section of the head (Fig. 135), a gray-white mass involving the...
Hereditary multiple exostoses a dominantly inherited hereditary disorder seen as a multiple cartilaginous tumors is certainly due to mutations PF-2545920 in associates from the gene family or and assays we present that EXT2 will not harbor significant glycosyltransferase activity in the lack of EXT1. in the growth bowl of endochondral bone tissue (1). This problem can result in skeletal abnormalities brief stature and occasionally malignant change from exostoses to chondrosarcomas (2 3 or osteosarcomas (4 5 Although hereditary linkage analysis provides discovered three different loci for HME on 8q24.1 on 11p11-13 and on 19p (6-8) most HME situations have been related to missense or frameshift mutations in either or (9-15). and encode 746- and 718-aa protein respectively that are PF-2545920 portrayed ubiquitously in individual tissue (9 16 Prior research using epitope-tagged constructs possess confirmed that EXT1 is certainly a mostly endoplasmic reticulum (ER)-localized glycoprotein whose ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Cancer that appears in the bone in the form of tumors is considered bone cancer or bone sarcoma. The most common form of bone cancer is Osteosarcoma which often appear in the knees, upper legs, and upper arms. Other forms of bone sarcoma include Chondrosarcoma which affects the cartilage in pelvis, upper legs, and shoulders; Chordoma which affects from base of the skull, all along the spine; and Ewings Sarcoma which affects the bone marrow and bones.
... Klinisches W rterbuch von Otto Dornbl th. Definition und Bedeutung im historischen Lexikon der medizinischen Begriffe
Bone cancer can originate either in the bone or when another cancer spreads to the bone. Most common types of bone cancer are osteosarcoma, Ewings sarcoma, and chondrosarcoma. Depending upon the stage of bone cancer, doctor may recommend various tre
Chordomas are lobulated and apparently capsulated tumours which arise from notochord and derive from ectoderm. Mainly seen in the sacrococygeal region, they may arise from the spheno-occipital region and protrude into the nasopharynx. While plain X-rays may show tumour with destruction of the clivus, CT-scan and MRI are essential assessment tools in delineating the gross margins of a chordoma [7]. Morphologically they can be confused with chondrosarcomas but they are characterised by bubble cells (physaliferous cells) with strands of spindle-shaped cells [8]. Immunohistochemistry is of diagnostic value and the tumour is stained positive to S-100, vimentin, epithelial membrane antigen and cytokeratin antibodies [5].. While radical surgical resection is the treatment of choice, this is rarely possible due to intracranial extension. There have been reports of using an endoscopic approach but in cases with extensive dural invasion, inferior clivus-centred tumours and large tumours extended to the ...
Synonyms for chondroma in Free Thesaurus. Antonyms for chondroma. 5 words related to chondroma: benign tumor, benign tumour, nonmalignant neoplasm, nonmalignant tumor, nonmalignant tumour. What are synonyms for chondroma?
Sz vesen tal lkozna dr. Brian Durie-val, a nemzetk zileg elismert miel ma-szak rt vel? K rd st tenne fel neki? J jj n el Orvos-Beteg Tal lkoz nkra!
The anatomic junction of the neural and facial viscerocranium is termed the skull base (). This area is critically important because it supports the brain and allows all the neurovascular structures to either enter or exit the skull.Neoplasms may ori
TY - JOUR. T1 - Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-κB signaling. AU - Wang, Jen Jui. AU - Huan, Steven Kuan Hua. AU - Hsieh, Kuo Hsien. AU - Chou, Hsiu Chu. AU - Hsiao, George. AU - Jayakumar, Thanasekaran. AU - Sheu, Joen Rong. PY - 2013/4. Y1 - 2013/4. N2 - Introduction: Midazolam, a benzodiazepine, has a hypnotic effect and is widely used as an intravenous sedative. Past studies have clearly established that midazolam has beneficial effects in attenuating ischemia-reperfusion injury more than other currently used sedative drugs. However, the role of midazolam on chondroprotection via inhibition of matrix metalloproteinases (MMPs) is warrant investigation. The aim of this study was to examine the mechanisms of action of midazolam on MMP expression via nuclear factor κB (NF-κB) signaling in activated chondrosarcoma cells maintained in vitro. Material and methods: Chondrocytes, SW1353 cells, were ...
VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons.Immunohistochemical staining with VS38c was carried out on formalin-fixed specimens of osteosarcoma (pre/post-chemotherapy) and a wide range of benign and malignant bone lesions. In addition, VS38c staining of cultures of MG63 and Sa0S2 osteosarcoma cell cultures. (±cisplatin and actinomycin D-treatment) was analysed.VS38c strongly stained tumour cells in all low-grade and high-grade osteosarcomas and in undifferentiated sarcomas and high-grade chondrosarcomas. There was little or no VS38c staining of low-grade chondrosarcomas or chordomas and variable staining of Ewing sarcomas. Osteoblasts in
An enchondroma is a type of noncancerous bone tumor that begins in cartilage. An enchondroma most often affects the cartilage that lines the inside of the bones. It often affects the tiny long bones of the hands and feet. It may also affect other bones such as the femur (thighbone), humerus (upper arm bone), or tibia (one of the two lower leg bones).
This two day European workshop is aimed at young researchers (post-docs, PhD, etc.) working on Bone Sarcoma/Sarcoma. The meeting aims to provide training in bone sarcoma and more specifically osteosarcoma, chondrosarcoma and Ewing sarcoma. Invited speaker presentations will be complemented by oral communications and poster presentations from attending delegates (priority given to young researchers).. ...
This type of cancer forms as a painful lump (tumour) in the bone. During a bone sarcomas growth stage, the cancer cells multiply and start to destroy the bone. This then causes the affected bone to become weak.. The most common places where bone sarcoma develops are around the knee, the wrist, the shoulder and the pelvis. They are mostly found in children, teenagers and young adults.. The most common type of bone cancer is osteosarcoma, which accounts for 5% of the tumours in children. This form of bone cancer is characterised by its millions of abnormal bone producing cells. Ewings sarcoma is another type of bone cancer, however this type of sarcoma can also occur as a soft tissue sarcoma, depending on the location of the tumour. Chondrosarcoma is also a bone sarcoma characterised by its millions of abnormal cartilage cells.. Symptoms of bone sarcomas depend on multiple factors, including the size and location of the tumour. One of the most common symptoms is pain, due to swelling and ...
Although the clinical classification of Maffucci syndrome is well defined, physical manifestation of the disease is often heterogeneous. Symptoms are not present at birth but generally occur in early childhood with several pleiotropic phenotypes.3 Skeletal deformations associated with enchondromas are variable, affecting both long and flat bones,4 and malignant transformation to chondrosarcoma is common. Furthermore, a broad spectrum of other cellular dysplasias has been reported, including ovarian, pancreatic, parathyroid, and pituitary tumors.5-7 A recent study suggests a receptor mutation for the parathyroid hormone, and related proteins may play a role in the broad spectrum of associated phenotypes.8 However, another study failed to confirm this finding, suggesting that multiple mechanisms are involved in the pathogenesis.9 Similarly, vascular lesions, although easily identified by small blue subcutaneous nodules, may appear in various other sites. Large hemangiomas have been sited within ...
CLINICAL STAGING. Thoracic CT scans are recommended to assess for metastasis to the lungs, and this can be done at the same time as assessment of the primary rib tumor.. TREATMENT. Chest wall resection and reconstruction is recommended for dogs with rib tumors. Six, and may be more, ribs can be resected without adversely affecting ventilatory function. In one study of 39 dogs with rib tumors, the rib tumor was either adhered to or invaded into the lungs in 31% of dogs, the pericardium in 13% of dogs, and the diaphragm in 5% of dogs. In these cases, contiguous organs or structures should be excised en bloc with the rib tumor. The chest wall defect is reconstructed with muscle flaps, prosthetic mesh, or diaphragmatic advancement depending on the location and size of the defect. Chemotherapy is recommended for dogs with osteosarcoma, but not chondrosarcoma.. PROGNOSIS. Osteosarcoma. The prognosis for dogs with rib osteosarcoma is guarded. Local recurrence is uncommon (12%). Local tumor recurrence ...
The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.
Background Tracheal autotransplantation is a reconstructive technique that allows for organ-sparing treatment of selected patients with advanced cricoid cartilage chondrosarcoma and T2 or T3...
Behringer, a world-class provider of bandsawing machines, circular cold saws and structural fabricating equipment, has added an automated inclined magazine to its HCS-90E carbide circular cold saw. The newly packaged HCS-90E now meets high production demands while minimizing the need for operator attendance. "Behringer has designed the HCS-90E saw for customers that literally need bulk cutting output in the thousands of pieces per day range," said Joe Suydam, Behringer sales and marketing associate. A fully automatic high-performance circular cold saw, the HCS-90E is designed for cutting ferrous material at 90 degrees in maximum yield applications. High throughput performance is facilitated by the saws inclined magazine which holds up to 3500 pounds of 12 long material. An optional extension expands material capacity to 20 long pieces and load capacity to 5250 pounds. Once loaded with bundles, the machine will run without interruption, cutting pre-programmed lengths, ejecting trim and ...
Surgery may also be necessary to correct painful limb abnormalities that are caused by multiple osteochondromas. Surgery may be needed to cut and realign the bones that have become deformed, which is known as osteotomy.[2] If the legs are not equal in length, treatment may include a procedure to slow down the growth of the longer leg. Surgery may also be needed to correct the forearm deformity seen in this condition. Adults with this condition who have untreated forearm deformities usually do not have significant functional limitations.[1] Although rare, an osteochondroma can become cancerous (malignant), which usually takes the form of a low grade chondrosarcoma. This type of malignant tumor is unlikely to spread elsewhere in the body. Higher grades of ...
The economic burden of bone cancers can be great. The more advanced the disease, the worse the prognosis and, accordingly, the more expensive the treatments. It is likely that early detection, and, certainly, prevention if possible, could drastically reduce costs. A number of expensive treatments are required to address these tumors. In the 2007 report by Damron, Ward, and Stewart,1 it was noted that the most frequent initial treatments varied widely based on the type of sarcoma. Although not reported, these treatments vary widely based on the stage of the disease as well.. Collectively, they reported that surgery alone was the most common initial treatment for chondrosarcomas (69%), whereas for Ewing sarcoma, treatments were divided between surgery and chemotherapy (24% of cases), radiation and chemotherapy (23%), and chemotherapy alone in 18%. With osteosarcoma, when initial treatment was known, the largest group received surgery and chemotherapy (46%). Surgery was reported as part of the ...
Osteosarcoma, a primary bone cancer. The osteosarcoma is one of the primary cancers of the bone, that is to say developed from bone cells, cartilage or fibrous tissue, as opposed to secondary cancers of the bone metastases that are of cancer in another organ. The osteosarcoma is primary bone cancer the most common, before the chondrosarcoma, Ewings sarcoma and multiple myeloma . Of unknown cause, osteosarcoma usually occurs in children and young adults, between 10 and 25 years. The bones are usually affected long bones near the knee or shoulder: tibia, femur and humerus. We traditionally distinguish two forms of osteosarcoma: one attacks the central part of the bone (medullary bone), the other in the peripheral zone of the bone, destroying the periosteum, the membrane that surrounds the bone and is responsible for its growth in thickness. You should also remember that osteosarcoma can spread through the bloodstream and invade the lungs causing pulmonary metastases.. The first signs of ...
Looking for online definition of Ollier's layer in the Medical Dictionary? Ollier's layer explanation free. What is Ollier's layer? Meaning of Ollier's layer medical term. What does Ollier's layer mean?
Our specialists see patients with all sarcomas and a variety of mesenchymal tumors, including chondrosarcoma, desmoid tumor, liposarcoma, neurofibrosarcoma, osteosarcoma, and rhabdomyosarcoma. Our group is also dedicated to clinical research to develop innovative treatment strategies for soft tissue and bone malignancies.
As for Genehunter1s query... Aspergillie is again right on. We gave up on commercial so-called primary chondrocyte lines early on, because they lost their phenotype quickly. Some people also use various chondrosarcomas for matrix studies too, usually in the context of protein production for structural biology, but you dont want to read too much into normal cartilage biology from these cell types. Weve found that isolating our own from weanling rat rib/costal cartilage works best for our studies. This (Bone. 1988;9(3):185-94) is a GREAT paper describing this method in detail especially regarding ECM characteristics. We can maintain growth cells in monloayer for about 15 passages before they get weird. The phenotypic shift is quite dramatic...they become spindly rather than their normal rounded/cuboid morphology and they just suddenly stop proliferating at the usual pace of a 36-48h doubling time to a week or more, so Im reasonably sure theyve changed biologically. This is when I can them ...
by Michael H. McGuire, MD Michael H. McGuire, MD, is professor and chairman, department of surgery, Creighton University, Omaha, Neb. The modern era of orthopaedics spans the 20th century. The transplantation of human cadaver allograft bones for the reconstruction of skeletal defects has been one of the highlights of the history of orthopaedic surgery during this century. An idea that was at one time surely a desperate response to a desperate problem has become a rather sophisticated system for planned reconstructions. Since the work of Parrish and others in the 1960s, surgeons have demonstrated the ability to perform limb-sparing resections of malignant tumors of the skeleton. Most estimates suggest that approximately 2,500 new cases of primary sarcomas of the skeleton are diagnosed each year. These are osteosarcomas and Ewings sarcomas in adolescents and chondrosarcomas and MFH/fibrosarcomas in older adults and elderly. These routinely arise from the appendicular skeleton. With early ...
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Strong flat bones have parallel surfaces which protect underlying tissues and provide broad surfaces for muscular attachment. An example includes the ...
Diagnosis of chondroma (costs for program #256553) ✔ University Hospital Erlangen ✔ Department of Hematology and Internal Oncology (Department of Medicine V) ✔ BookingHealth.com
Diagnosis of chondroma (costs for program #235279) ✔ University Hospital Ulm ✔ Deparment of Orthopedics ✔ BookingHealth.com
Hereditary multiple exostosis (HME) / Hereditäre Multiple Exostose, Multiple exostosis disease, Multiple cartilagenous exostoses, Multiple osteochondroma, Multiple cartilagenous exostosis, Diaphyseal aclasis, Endochondromatosis
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
The importance of understanding how costal cartilage chondrocytes respond to stimuli such as oxidative stress and low pH has been largely overlooked in studies involving tissue culturing due to major differences between oxygen and pH levels during incubation and the natural environment of hyaline cartilage. Hyaline cartilage is avascular and naturally hypoxic which subsequently leads to increased glycolytic metabolism and ultimately causes a decrease in extracellular pH. To examine how healthy costal cartilage responds to these extreme growth conditions, we examined responses in three hyaline cartilage diseases. Our ability to identify the disease mechanisms responsible for pectus excavatum, pectus carinatum, and chondrosarcoma are limited by our understanding of how these mechanisms operate. This study aimed to determine the roles of hypoxia and extracellular acidosis on the expression of genes related to the hypoxia response pathway in costal cartilage chondrocytes, two pectus chest wall deformities,
Angiosarcoma, carcinosarcoma, chondrosarcoma, clear cell, dermatofibrosarcoma protuberans, epithelioid, ewings, gastrointestinal stromal tumor, hemangiopericytoma, histiocytic, leiomyosarcoma, liposarcoma, malignant fibrous histiocytoma, myxofibrosarcoma, osteosarcoma, primitive neuro-echtodermal, rhabdomyosarcoma, sarcoma, soft tissue, synovial, undifferentiated pleomorphic, Wilms Tumor This is an open group, members can apply to join.. ...
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Synovial Chondrosarcoma Arising in Synovial ChondromatosisSynovial Chondrosarcoma Arising in Synovial Chondromatosis

... Scott Evans, Michele Boffano, Samena Chaudhry, Lee Jeys, and Robert ... F. Bertoni, K. K. Unni, J. W. Beabout, and F. H. Sim, "Chondrosarcoma of the synovium," Cancer, vol. 67, pp. 155-162, 1991. ... L. D. Rybak, L. Khaldi, J. Wittig, and G. C. Steiner, "Primary synovial chondrosarcoma of the hip joint in a 45-year-old male: ... W. K. Taconis, R. O. van der Heul, and A. M. M. Taminiau, "Synovial chondrosarcoma: report of a case and review of the ...
more infohttps://www.hindawi.com/journals/sarcoma/2014/647939/ref/

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.  - PubMed -...The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. - PubMed -...

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.. Filion C1, ... The NR4A3 nuclear receptor is implicated in the development of extraskeletal myxoid chondrosarcoma (EMC), primitive sarcoma ... The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene ... The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/18855877

IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...IL-8 increases integrin expression and cell motility in human chondrosarcoma cells - Lee - 2011 - Journal of Cellular...

Tzu-Wei Tan, Ying-Erh Chou, Wei-Hung Yang, Chin-Jung Hsu, Yi-Chin Fong, Chih-Hsin Tang, Naringin suppress chondrosarcoma ... Chi-Ming Wu, Te-Mao Li, Tzu-Wei Tan, Yi-Chin Fong, Chih-Hsin Tang, Berberine Reduces the Metastasis of Chondrosarcoma by ... Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. ... Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/jcb.23179/abstract

IJMS | Free Full-Text | 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human...IJMS | Free Full-Text | 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human...

Here we found that BPB induced apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353) but not in primary chondrocytes ... Thus, BPB may be a novel anticancer agent for the treatment of chondrosarcoma. ... in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo ... Bid and Bcl-XL and dysfunction of mitochondria in chondrosarcoma. In addition, BPB also promoted cytosolic releases AIF and ...
more infohttp://mdpi.com/1422-0067/13/12/16472

Orbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis | springermedizin.atOrbito-maxillofacial mesenchymal chondrosarcoma with intracranial invasion and lung metastasis | springermedizin.at

Chondrosarcoma of the maxilla: a case report and review of literature. J Oral Maxillofac Pathol. 2013;17:269-73. CrossRefPubMed ... Mesenchymal chondrosarcoma of the orbit: CT and MRI Findings. Clin Radiol. 2012;67:346-51. CrossRefPubMed ... Chondrosarcoma of the maxilla: report of two cases with different behaviours. J Craniomaxillofac Surg. 2012;40:71-4. CrossRef ... Case report: chondrosarcoma of the head and neck. Hum Pathol. 2015; doi: 10.​1016/​j.​ehpc.​2015.​07.​002. Quevedo FC, ...
more infohttps://www.springermedizin.at/orbito-maxillofacial-mesenchymal-chondrosarcoma-with-intracrania/14930916?fulltextView=true

Xylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycanXylosyl transfer to the core protein precursor of the rat chondrosarcoma proteoglycan

... Lohmander, Stefan LU ; Shinomura, T.; ... Rat chondrosarcoma chondrocytes were labeled with [3H]serine or [3H]mannose as a precursor. Intracellular proteoglycan core ... Rat chondrosarcoma chondrocytes were labeled with [3H]serine or [3H]mannose as a precursor. Intracellular proteoglycan core ... article{52f6a2c0-7074-42f4-ae84-0c0dbf6711b3, abstract = {,p,Rat chondrosarcoma chondrocytes were labeled with [,sup,3,/sup,H] ...
more infohttps://lup.lub.lu.se/search/publication/52f6a2c0-7074-42f4-ae84-0c0dbf6711b3

Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation --...Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation --...

We detected telomerase expression in 7 of 16 chondrosarcomas, but cells cultured from telomerase-negative chondrosarcomas ... Human chondrosarcomas do not respond to current chemotherapies or radiation therapy, and their size and histological appearance ... Malignant Transformation in Human Chondrosarcoma Cells Supported by Telomerase Activation and Tumor Suppressor Inactivation1 ... that telomerase activation and loss of cell cycle control leads to the emergence of aggressive cells from chondrosarcoma cell ...
more infohttp://cgd.aacrjournals.org/cgi/content/abstract/13/9/397

Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human...Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human...

We also found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of the COX-2 which was ... In this study, we examined whether COX-2 and EP interaction are involved in metastasis of human chondrosarcoma. We found that ... Furthermore, we found that human chondrosarcoma tissues expressed a higher level of EP1 receptor than normal cartilage. PGE2- ... Our results indicated that PGE2 enhances the migration of chondrosarcoma cells by increasing α2β1 integrin expression through ...
more infohttps://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-43

Enchondromatosis: insights on the different subtypesEnchondromatosis: insights on the different subtypes

Secondary central chondrosarcoma. While solitary enchondromas almost never progress to secondary central chondrosarcoma, ... Enchondroma and chondrosarcoma. Semin Musculoskelet Radiol. 2000;4:59-71. [PubMed]. 34. Mertens F, Unni KK. Enchondromatosis: ... Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease. Cancer Genet Cytogenet. 1998;105:128-33. [PubMed] ... Chondrosarcoma in Maffuccis syndrome. J Bone Joint Surg. 1985;67A:1214-9. [PubMed] ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC2907117/

Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of...

RESULTS: The induction of IL-6 and IL-8 clearly depended on NF-kappaB in both fibroblasts and chondrosarcoma cells, ... OBJECTIVE: To determine whether, in human fibroblasts and chondrosarcoma cells, the regulation of interleukins (IL)-6, 8, and ... Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of ... Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of ...
more infohttp://orca.cf.ac.uk/57288/

Functional genomic analyses of the impact of global hypomethylation an by Christopher Allan Hamm"Functional genomic analyses of the impact of global hypomethylation an" by Christopher Allan Hamm

The model, known as the Swarm rat chondrosarcoma (SRC), resembles human chondrosarcoma and provides a system to study tumor ... To achieve a greater understanding of chondrosarcoma tumorigenesis, a model for human chondrosarcoma has been established in a ... Previous studies with SRC revealed that tumor microenvironment can significantly influence chondrosarcoma malignancy, but the ... The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. ...
more infohttp://ir.uiowa.edu/etd/372/

malignant skull base tumors |  UC Irvine Health | Orange County, CAmalignant skull base tumors | UC Irvine Health | Orange County, CA

Chondrosarcomas, which consist mostly of cartilage and can range in severity from cancers that are unlikely to spread to ... Chondrosarcomas require surgery. Radiotherapy and chemotherapy may also be performed after surgery if the tumor resides in a ...
more infohttp://www.ucirvinehealth.org/medical-services/skull-base-surgery/malignant-skull-base-tumors

Physical Examination Trumps Mediastinoscopy in Diagnosing Maffucci Syndrome: A Rare Cause of Mediastinal Mass | Anesthesiology ...Physical Examination Trumps Mediastinoscopy in Diagnosing Maffucci Syndrome: A Rare Cause of Mediastinal Mass | Anesthesiology ...

A 50-yr-old male with medical history significant for chondrosarcoma of the left tibia, Kaposis sarcoma (non-human ... Tumors have a high rate of malignant transformation; for example, chondrosarcomas, the most common type of enchondroma, occur ... Tibbs RE, Bowles AP, Raila FA: Maffuccis syndrome and intracranial chondrosarcoma. Skull Base Surg 1997; 7:49-55Tibbs, RE ... A literature search crossing the terms "hemangiomas" and a "chondrosarcoma" yielded the diagnosis of Maffucci syndrome. ...
more infohttp://anesthesiology.pubs.asahq.org/article.aspx?articleid=1924040

Chondroma synonyms, chondroma antonyms - FreeThesaurus.comChondroma synonyms, chondroma antonyms - FreeThesaurus.com

... although a CT that shows coarse or stippled calcifications may raise the suspicion of a chondrosarcoma.. Chondrosarcoma of the ... However, it is difficult to distinguish a chondrosarcoma from a benign chondroma on imaging, ... The differential diagnosis of a cholesterol granuloma includes cholesteatoma, mucocele, chondroma, chondrosarcoma, metastatic ... from a well-differentiated chondroma or low-grade chondrosarcoma to the anaplastic features of a high-grade chondrosarcoma ( ...
more infohttps://www.freethesaurus.com/chondroma

Characteristics of gliomas in patients with somatic IDH mosaicism | Acta Neuropathologica Communications | Full TextCharacteristics of gliomas in patients with somatic IDH mosaicism | Acta Neuropathologica Communications | Full Text

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other ... At this time, six patients (19 %) had a previous history of chondrosarcoma. Clinical presentation consisted of a variable ... Enchondromas appear during childhood and may progress to chondrosarcomas in up to 30 % of cases [3, 36]. In Maffucci syndrome, ... IDH mutations have been shown to be sufficient to induce enchondromas and chondrosarcomas [17, 29]. To our knowledge, this ...
more infohttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0302-y

Neurosurgical Consultants: Nervous System Tumors - Benign: Skull Base TumorsNeurosurgical Consultants: Nervous System Tumors - Benign: Skull Base Tumors

Chondrosarcoma is the malignant tumor that occurs in this area.. Another way to classify these tumors is by their area of ... POSTERIOR CRANIAL FOSSA/PETROUS RIDGE CHONDROSARCOMA. Figure 6A (Left): MRI Scan (Axial View) A Left Petrous Ridge (Skull Base ... The tumor proved to be A Myxoid Chondrosarcoma in a 47 year old Female. Additional treatment will be required in order to ... Figure 7: Intra-operative Real Time "Image Guided" Minimally Invasive Resection of a Left Petrous Ridge Chondrosarcoma (Same ...
more infohttp://neurosurgerydallas.com/2_1_6_14.php

Recurrent Extra- and Intra-articular Synovial Chondromatosis of the Ankle with Tarsal Tunnel Syndrome: A Rare Case Report  |...Recurrent Extra- and Intra-articular Synovial Chondromatosis of the Ankle with Tarsal Tunnel Syndrome: A Rare Case Report |...

Synovial chondrosarcoma arising from synovial chondromatosis of the knee. JBR-BTR 2012;95(6):360-362.. 8. Kirchhoff C, Buhmann ... carries risk of complications such as osteoarthritis as well as a minimal risk for malignant transformation to chondrosarcoma [ ...
more infohttp://www.jocr.co.in/wp/2017/03/10/2250-0685-752-fulltext/

Diagnosing Skull Base Tumors | Pelisyonkis Langone Health- pelisyonkis.infoDiagnosing Skull Base Tumors | Pelisyonkis Langone Health- pelisyonkis.info

Chordomas and chondrosarcomas are especially prone to destroying the bones of the skull base. ...
more infohttp://pelisyonkis.info/conditions/skull-base-tumors/diagnosis

Bulletin 02-15 ChondrosarcomaBulletin 02-15 Chondrosarcoma

EEOICPA BULLETIN NO.02-16 Issue Date: July 15, 2002. ________________________________________________________________. Effective Date: June 12, 2002. ________________________________________________________________. Expiration Date: June 12, 2003. ________________________________________________________________. Subject: Ureter Cancer as a Specified Primary Cancer Background: The Department of Labor (DOL) recently forwarded the medical evidence in a case file to the National Cancer Institute (NCI) for their review and opinion to determine if, for purposes of being considered a specified cancer under the EEOICPA, ureter cancer can be considered urinary bladder cancer.. The expert medical opinion obtained from the NCI indicates that superficial transitional cell carcinomas of the urinary epithelium are biologically identical wherever they arise within the urinary tract and indeed, they are often multifocal. The etiologic (including environmental) influences on urothelial carcinogenesis and the ...
more infohttps://www.dol.gov/owcp/energy/regs/compliance/PolicyandProcedures/finalbulletinshtml/bulletin_02-16_ureter_cancer_bulletin.htm

Chondrosarcoma | Encyclopedia.comChondrosarcoma | Encyclopedia.com

Chondrosarcoma Definition Chondrosarcoma is a malignant tumor that arises from cells that produce cartilage, the rubbery tissue ... Central chondrosarcoma and peripheral chondrosarcoma are both classic chondrosarcomas. Central chondrosarcoma occurs within a ... clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. Clear cell chondrosarcoma is the ... There are two different categories of chondrosarcomas-classic chondrosarcomas and variant chondrosarcomas. Together they have ...
more infohttps://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/chondrosarcoma

Chondrosarcoma - WikipediaChondrosarcoma - Wikipedia

Therapeutic molecular targets in human chondrosarcoma .Int J Exp Pathol 2010; 91:387-93 Chondrosarcoma of Bone Chondrosarcoma ... Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage. Chondrosarcoma is a member ... File:Metastatic chondrosarcoma at the lower lip.jpgFile:Metastatic chondrosarcoma at the lower lip.jpg Imaging studies - ... "Chondrosarcoma: Overview - eMedicine Radiology". Retrieved 2009-02-14. "Chondrosarcoma : Cancerbackup". Retrieved 2009-02-14. ...
more infohttps://en.wikipedia.org/wiki/Chondrosarcoma

Neurinoma: Chondrosarcoma of the Thoracic Spine | SpringerLinkNeurinoma: Chondrosarcoma of the Thoracic Spine | SpringerLink

Katonis P et al (2011) Spinal chondrosarcoma: a review. Sarcoma 2011:378957, 10 pagesCrossRefPubMedPubMedCentralGoogle Scholar ... Strike SA, McCarthy EF (2011) Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J ... Špero M. (2018) Neurinoma: Chondrosarcoma of the Thoracic Spine. In: Neuroradiology - Expect the Unexpected. Springer, Cham. * ... Lloret I et al (2006) Primary spinal chondrosarcoma: radiologic findings with pathological correlation. Acta Radiol 47(1):77-84 ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-73482-8_21

Chondrosarcoma: Practice Essentials, Background, PathophysiologyChondrosarcoma: Practice Essentials, Background, Pathophysiology

Chondrosarcoma is a collective term for a group of tumors that consist predominantly of cartilage and that range from low-grade ... encoded search term (Chondrosarcoma) and Chondrosarcoma What to Read Next on Medscape. Related Conditions and Diseases. * Fast ... Chondrosarcoma types and grades. Different types of chondrosarcoma have been described, as follows:. * Conventional ... Different types of chondrosarcoma have been described, as follows:. * Conventional chondrosarcoma, which accounts for nearly 90 ...
more infohttps://emedicine.medscape.com/article/1258236-overview
  • However, it is difficult to distinguish a chondrosarcoma from a benign chondroma on imaging, although a CT that shows coarse or stippled calcifications may raise the suspicion of a chondrosarcoma. (freethesaurus.com)
  • These results indicate, in agreement with our previous kinetic data, that the major part of the xylosyl transfer to the chondrosarcoma proteoglycan core protein precursor must occur late in the processing sequence, i.e. after about 85% of its intracellular lifetime and no more than 7 min before the addition of the rest of the chondroitin sulfate chain. (lu.se)
  • Rat chondrosarcoma chondrocytes were labeled with [ 3 H]serine or [ 3 H]mannose as a precursor. (lu.se)
  • However, the effects of COX-2 on migration activity in human chondrosarcoma cells are mostly unknown. (biomedcentral.com)
  • We found that over-expression of COX-2 or exogenous PGE 2 increased the migration of human chondrosarcoma cells. (biomedcentral.com)
  • Our results indicated that PGE 2 enhances the migration of chondrosarcoma cells by increasing α2β1 integrin expression through the EP1/PLC/PKCα/c-Src/NF-κB signal transduction pathway. (biomedcentral.com)
  • Case report: chondrosarcoma of the head and neck. (springermedizin.at)
  • Clinicopathological analysis of head and neck chondrosarcoma: three case reports and literature review. (springermedizin.at)
  • Zurück zum Zitat Halefoglu AM. Magnetic resonance imaging of neck chondrosarcoma: a case report. (springermedizin.at)
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