AnatomyChemicals and DrugsDisciplines and Occupations
Chondroitin ABC LyaseChondroitin LyasesChondroitin SulfatesChondroitinDermatan SulfateChondroitin Sulfate ProteoglycansChondroitinases and Chondroitin LyasesChromogranin AProteoglycansChromaffin GranulesHeparan Sulfate ProteoglycansCorneal KeratocytesKeratan SulfateCorneal StromaCorneaJNK Mitogen-Activated Protein KinasesGlycomicsAntibodies, MonoclonalCarbohydratesResearch
Chondroitin ABC Lyase
An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)
Chondroitin Lyases
Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.
Chondroitin Sulfates
Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
Chondroitin
A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Dermatan Sulfate
A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)
Chondroitin Sulfate Proteoglycans
Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.
Chondroitinases and Chondroitin Lyases
Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.
Chromogranin A
A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Proteoglycans
Glycoproteins which have a very high polysaccharide content.
Chromaffin Granules
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
Heparan Sulfate Proteoglycans
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
Corneal Keratocytes
Fibroblasts which occur in the CORNEAL STROMA.
Keratan Sulfate
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Corneal Stroma
The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
Cornea
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
JNK Mitogen-Activated Protein Kinases
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
Glycomics
The systematic study of the structure and function of the complete set of glycans (the glycome) produced in a single organism and identification of all the genes that encode glycoproteins.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Carbohydrates
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)

Identification and characterization of ligands for L-selectin in the kidney. II. Expression of chondroitin sulfate and heparan sulfate proteoglycans reactive with L-selectin. (1/161)

Ligands for the leukocyte adhesion molecule L-selectin are expressed not only in lymph node high endothelial venules (HEV) but also in the renal distal tubuli. Here we report that L-selectin-reactive molecules in the kidney are chondroitin sulfate and heparan sulfate proteoglycans of 500-1000 kDa, unlike those in HEV bearing sialyl Lewis X-like carbohydrates. Binding of L-selectin to these molecules was mediated by the lectin domain of L-selectin and required divalent cations. Binding was inhibited by chondroitinase and/or heparitinase but not sialidase. Thus, L-selectin can recognize chondroitin sulfate and heparan sulfate glycosaminoglycans structurally distinct from sialyl Lewis X-like carbohydrates.  (+info)

Action of chondroitinases. II. Numerical calculation of the degree of multiple attack. (2/161)

Further investigation was carried out on the action patterns of two chondroitinase-AC [EC 4.2.2.5.] preparations obtained from Arthrobacter aurescens and Flavobacterium heparinum. To infer the action patterns of the chondroitinases, we proposed a new method for the calculation of the degree of multiple attack, based on the concept established by Robyt and French ((1967) Arch. Biochem. Biophys. 122, 8-16). It was shown that the degree of multiple attack (DM) is represented by the ratio of the initial velocity of number-average degree of scission to that of viscosity-average degree of scission. By this method, DM for A-Chase was estimated to be 3.03 and for F-chase, 1.31.  (+info)

Perineuronal nets of proteoglycans in the adult mouse brain, with special reference to their reactions to Gomori's ammoniacal silver and Ehrlich's methylene blue. (3/161)

As our previous studies have indicated, many subsets of neurons in the vertebrate brain possess a sulfated proteoglycan surface coat which reacts to cationic iron colloid and aldehyde fuchsin. The present study demonstrated that this surface coat is supravitally stained with Ehrlich's methylene blue, and doubly with this blue and aldehyde fuchsin, a finding suggesting its being identical to Cajal's superficial reticulum (red superficial) and to Golgi's reticular coating (revetement reticulare). The perineuronal surface coat was further stained with Gomori's ammoniacal silver, and doubly with this silver and cationic iron colloid. These neurons with such a proteoglycan surface coat usually expressed cell surface glycoproteins which were labeled with lectin Wisteria floribunda agglutinin. Hyaluronidase digestion did not interfere with this lectin labeling of the glycoproteins, methylene blue and Gomori's ammoniacal silver staining of the surface coat, while it erased the cationic iron colloid and aldehyde fuchsin staining of the surface coat. These findings suggest that the perineuronal proteoglycan surface coat is associated with some additional molecules which are resistant to hyaluronidase digestion and stainable with methylene blue and Gomori's ammoniacal silver. The possibility is suggested that these molecules might represent "ligand proteoglycans" connecting the perineuronal proteoglycans and cell surface glycoproteins.  (+info)

Isolation and characterization of proteoglycans from human follicular fluid. (4/161)

Two proteoglycans differing in size and composition were isolated from human follicular fluid. The larger one of high density had a molecular mass of 3.0x10(6) Da, as determined by laser light-scattering, and was substituted with 15-20 chondroitin sulphate (CS) chains (Mr 60000-65000). Half of the CS disaccharides were 6-sulphated, whereas the remaining ones were non-sulphated. Digestion of the CS proteoglycan with chondroitinase ABC lyase, followed by SDS/PAGE, yielded a protein core of 600 to 700 kDa including substituted oligosaccharides, and a band of 70 kDa that was identified as the heavy-chain component of the inter-alpha-trypsin inhibitor (ITI). Western blotting of the CS proteoglycan showed that this had reactivity with antibodies raised against human versican. Electron microscopy (EM) of the CS proteoglycan also revealed a versican-like structure, with one globular domain at each end of a long extended segment substituted with CS side chains, as well as a structure interpreted as being the heavy chain of ITI attached to CS chains. Laser light-scattering revealed that the smaller proteoglycan had a molecular mass of 1. 1x10(6) Da, and EM demonstrated that it had a globular-protein core structure. The core protein, which showed immunological reactivity with perlecan antibodies, was substituted with approximately seven heparan sulphate (HS) and CS chains of similar size (50-55 kDa), the CS disaccharides being mainly 6-sulphated (68%), with a small proportion being 4-sulphated. The protein core was shown to be heterogeneous, with bands occurring at 215, 330 and 400 kDa after enzymic degradation of the glycosaminoglycan chains followed by SDS/PAGE analysis. The demonstration of intact molecules and fragments obtained after stepwise degradations, as shown by gel chromatography, supported a 'composite' structure of this proteoglycan.  (+info)

Differentiation of human monocytes to monocyte-derived macrophages is associated with increased lipoprotein lipase-induced tumor necrosis factor-alpha expression and production: a process involving cell surface proteoglycans and protein kinase C. (5/161)

The aim of the present study was to (1) evaluate the responsiveness of human mononuclear cells to lipoprotein lipase (LPL), as assessed by tumor necrosis factor-alpha (TNFalpha) production, during the process of differentiation of monocytes to macrophages, and (2) determine the mechanisms by which LPL exerts its effect on these cells. Treatment of human monocytes with purified endotoxin-free bovine LPL (1 microgram/mL) resulted in a 161+/-15% increase in TNFalpha production over control values (P<0.01). A further increase in TNFalpha production was observed after treatment of monocyte-derived macrophages (MDMs) with LPL (490+/-81% over control values, P<0.01). Increased TNFalpha mRNA expression and protein kinase C activity were also observed in LPL-treated human monocytes and MDMs. These LPL effects were abrogated by the specific protein kinase C inhibitor calphostin C (1 micromol/L). Although heparinase totally abolished LPL-induced TNFalpha production in human monocytes, this agent did not significantly inhibit LPL effect in human MDMs. In contrast, treatment of MDMs with chondroitinase suppressed LPL-induced TNFalpha production. Taken together, these data suggest that (1) differentiation of human monocytes to MDMs is associated with increased LPL-induced TNFalpha mRNA expression and production, (2) a protein kinase C-dependent pathway is involved in the induction of TNFalpha by LPL in these cells, and (3) LPL effect is mediated by cell surface proteoglycans. As MDMs secrete LPL in the vascular wall, we propose that LPL, by acting as an autocrine activator of MDM function, may contribute to the high level of TNFalpha found in the atheromatous lesion.  (+info)

The macromolecular characteristics of cartilage proteoglycans do not change when synthesis is up-regulated by link protein peptide. (6/161)

Previous studies have shown that a synthetic, unglycosylated analogue of the N-terminal peptide from link protein can function as a growth factor and up-regulate proteoglycan biosynthesis in explant cultures of normal human articular cartilage from a wide age range of subjects (McKenna et al., Arthritis Rheum. 41 (1998) 157-162). The present work further shows that link peptide increased proteoglycan synthesis by cartilage cultured in both the presence and absence of serum, suggesting that the mechanism of up-regulation may be different from that of insulin-like growth factors. The proteoglycans synthesised during stimulation with link peptide were of normal hydrodynamic size and the ratio of core protein to glycosaminoglycan side chains and the proportions of the large proteoglycan aggrecan to the small proteoglycans, decorin and biglycan, remained constant. Aggrecan molecules were equally capable of forming aggregates as those from control tissues and the relative proportions of decorin and biglycan were unchanged showing that both were co-ordinately up-regulated. These results confirmed that this novel peptide is a potent stimulator of proteoglycan synthesis by articular cartilage and showed that the newly synthesised proteoglycans were of normal composition.  (+info)

Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases. (7/161)

Intact fibronectin (FN) protects cells from apoptosis. When FN is fragmented, specific domains induce proteinase expression in fibroblasts. However, it is not known whether specific domains of FN can also regulate apoptosis. We exposed fibroblasts to four recombinant FN fragments and then assayed for apoptosis using criteria of cellular shape change, condensed nuclear morphology, and DNA fragmentation. The fragments extended from the RGD-containing repeat III10 to III15; they included (V(+)) or excluded (V(-)) the alternatively spliced V region and contained either a mutated (H(-)) or an unmutated (H(+)) heparin binding domain. Only the V(+)H(-) fragment triggered decreases in pp125(FAK) levels and apoptosis, which was rescued by intact FN and inhibitors of caspase-1 and caspase-3. This apoptotic mechanism was mediated by a chondroitin sulfate proteoglycan, since treating cells with chondroitin sulfate or chondroitinase reversed the apoptotic cell shape changes. The alpha4 integrin receptor may also be involved, since using a blocking antibody to alpha4 alone induced apoptotic cell shape changes, whereas co-treatment with this antibody plus V(+)H(+) reversed these effects. These results demonstrate that the V and heparin binding domains of FN modulate pp125(FAK) levels and regulate apoptosis through a chondroitin sulfate proteoglycan- and possibly alpha4 integrin-mediated pathway, which triggers a caspase cascade.  (+info)

Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7). (8/161)

Many matrix metalloproteinases (MMPs) are tightly bound to tissues; matrilysin (MMP-7), although the smallest of the MMPs, is one of the most tightly bound. The most likely docking molecules for MMP-7 are heparan sulfate proteoglycans on or around epithelial cells and in the underlying basement membrane. This is established by extraction experiments and confocal microscopy. The enzyme is extracted from homogenates of postpartum rat uterus by heparin/heparan sulfate and by heparinase III treatment. The enzyme is colocalized with heparan sulfate in the apical region of uterine glandular epithelial cells and can be released by heparinase digestion. Heparan sulfate and MMP-7 are expressed at similar stages of the rat estrous cycle. The strength of heparin binding by recombinant rat proMMP-7 was examined by affinity chromatography, affinity coelectrophoresis, and homogeneous enzyme-based binding assay; the K(D) is 5-10 nM. Zymographic measurement of MMP-7 activity is greatly enhanced by heparin. Two putative heparin-binding peptides have been identified near the C- and N-terminal regions of proMMP-7; however, molecular modeling suggests a more extensive binding track or cradle crossing multiple peptide strands. Evidence is also found for the binding of MMP-2, -9, and -13. Binding of MMP-7 and other MMPs to heparan sulfate in the extracellular space could prevent loss of secreted enzyme, provide a reservoir of latent enzyme, and facilitate cellular sensing and regulation of enzyme levels. Binding to the cell surface could position the enzyme for directed proteolytic attack, for activation of or by other MMPs and for regulation of other cell surface proteins. Dislodging MMPs by treatment with compounds such as heparin might be beneficial in attenuating excessive tissue breakdown such as occurs in cancer metastasis, arthritis, and angiogenesis.  (+info)

Reactome | Chondroitin sulfate/dermatan sulfate metabolismReactome | Chondroitin sulfate/dermatan sulfate metabolism
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
https://reactome.org/content/detail/R-HSA-1793185
In vitro and pilot in vivo evaluation of a bioactive coating for stent grafts based on chondroitin sulfate and epidermal growth...In vitro and pilot in vivo evaluation of a bioactive coating for stent grafts based on chondroitin sulfate and epidermal growth...
Purpose: To evaluate the potential of a bioactive coating based on chondroitin sulfate (CS) and tethered epidermal growth factor (EGF) for the improvement of healing around stent-grafts (SG). Methods: The impact of the bioactive coating on cell survival was tested in vitro on human vascular cells using polyethylene terephtalate films (PET) as a substrate. After being transferred onto a more realistic material (expanded poly(tetrafluoroethylene), ePTFE), the durability and mechanical behavior of the coating in addition to cell survival were studied. Preliminary in vivo testing was performed in a canine iliac aneurysm model reproducing type I endoleaks (3 animals with 1 control and 1 bioactive SG for each). Results: The CS and EGF coatings significantly increased survival of human smooth muscle cells and fibroblasts, compared with bare PET or ePTFE (P,.05). The coating also displayed good durability over 30 days according to ELISA and cell-survival tests. The coating did not affect the ...
http://espace2.etsmtl.ca/id/eprint/12584/
New study on Chondroitin Sulfate Market Astonishing Growth, Technology and Top key vendors: TSI Group Ltd.; Qingdao Wan tulmin...New study on Chondroitin Sulfate Market Astonishing Growth, Technology and Top key vendors: TSI Group Ltd.; Qingdao Wan tulmin...
According to a new report, Chondroitin Sulfate Market Size, Share & Trends Analysis Report By Source (Synthetic, Bovine, Swine, Poultry, Shark), By Application (Nutraceuticals, Pharmaceuticals, Animal Feed, Personal Care), And Segment Forecasts, 2019 - 2025, published by Grand View Research, Inc.,. The global chondroitin sulfate market size is expected to reach USD 1.4 billion by 2025, accelerating at a CAGR of 3.2% over the forecast period, according to a new report by Grand View Research, Inc. Increasing consumption of joint health supplements owing to rising prevalence of arthritis among obese and geriatric population is projected to drive the product demand.. Clinical efficacy and joint health benefits offered are the major factors triggering the demand for the product. Rising utilization of pharmaceutical grade sodium chondroitin sulfate to cure osteoarthritis is projected to drive industry growth. The market is highly influenced by Chinese dominated product supply, which as per the ...
http://news.onlinesharemarketnews.com/story/223283/new-study-on-chondroitin-sulfate-market-astonishing-growth-technology-and-top-key-vendors-tsi-group-ltd-qingdao-wan-tulmin-biological-products-co-ltd-brf-etc.html
Re: RC: Joint lubesRe: RC: Joint lubes
I thought these nutraceuticals were a bunch of boloney until, with no other management changes, my friends gelding went from lame at a walk to sound at a trot - he had been lame for some time with arthritis. (he is on chondroitin sulfate) What else is out there worth trying, and AERC legal? Maybe something to keep my muscles from getting so sore/stiff after a ride. Shelly in DE ...
http://www.endurance.net/RideCamp/archives/past/00/11/msg00029.html
Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags - Chemical...Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags - Chemical...
Small ubiquitin like modifier (SUMO) proteins are known to regulate many important cellular processes such as transcription and apoptosis. Recently, hybrid SUMO-ubiquitin chains containing SUMO-2 linked to Lys63-di-ubiquitin were found to play a major role in DNA repair. Despite some progress in understandin
http://pubs.rsc.org/en/content/articlelanding/2017/sc/c7sc00488e
KEGG PATHWAY: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human)KEGG PATHWAY: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human)
Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit of beta-D-galactosamine (GalNAc) and beta-D-glucuronic acid (GlcA), and often modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates (IdoA). CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues [MD:M00057]. The assembly process of CS is initiated by transferring GalNAc residue to the linkage tetrasaccharide. The polymerization is catalyzed by bifunctional enzymes (chondroitin synthases) possessing both beta 1,3 glucuronosyltransferase and beta 1,4 N-acetylgalactosaminyltransferase activities [MD:M00058]. Chondroitin polymerization also ...
http://www.kegg.jp/kegg-bin/highlight_pathway?scale=1.0&map=hsa00532
Chondroitin - WikipediaChondroitin - Wikipedia
Chondroitin is a chondrin derivative. Types include: Chondroitin sulfate Dermatan sulfate Chondroitin at the US National Library of Medicine Medical Subject Headings (MeSH ...
https://en.wikipedia.org/wiki/Chondroitin
Mutagenetix > Incidental...Mutagenetix > Incidental...
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced epimerase activity in the skin, lung, liver, spleen, kidney and brain and reduced iduronic acid content in the brain and kidney chondroitin sulfate/dermatan sulfate. [provided by MGI curators ...
https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=363827
CellNEWS: Xenotransplanting embryonic pig pancreatic cellsCellNEWS: Xenotransplanting embryonic pig pancreatic cells
Cross-species transplant in rhesus macaques is step toward diabetes cure for humans Friday, 19 October 2007 With an eye on curing diabetes, scientists at Washington University School of Medicine in St. Louis have successfully transplanted embryonic pig pancreatic cells destined to produce insulin into diabetic macaque monkeys - all without the need for risky immune suppression drugs that prevent rejection. The transplanted cells, known as primordia, are in the earliest stages of developing into pancreatic tissues. Within several weeks of the transplants, the cells became engrafted, or established, within the three rhesus macaque monkeys that received them. The cells also released pig insulin in response to rising blood glucose levels, as would be expected in healthy animals and humans. The approach reduced the animals need for insulin injections and has promise for curing diabetes in humans, says senior investigator Marc Hammerman, M.D., the Chromalloy Professor of Renal Diseases in Medicine. ...
http://cellnews-blog.blogspot.com/2007/10/xenotransplantation-embryonic-pig.html
Chondroitin Sulfate-RhB, Fluorescent Chondroitin Sulfates Shirley - Science MarketplaceChondroitin Sulfate-RhB, Fluorescent Chondroitin Sulfates Shirley - Science Marketplace
Biological Sciences Shirley, Chondroitin Sulfate is labeled with Rhodamine B. Lyophilized powder. The product is furnished for LABORATORY RESEARCH US...
http://science-marketplace.org/project-offers-collaborations/biological-sciences/chondroitin-sulfate-rhb-fluorescent-chondroitin-sulfates_i11987
Page Comparison - Ab1-2B6 (v.65 vs v.66) - Antibodies - ZFIN Community WikiPage Comparison - Ab1-2B6 (v.65 vs v.66) - Antibodies - ZFIN Community Wiki
Monoclonal antibody 2B6, recognises only the neoepitope created by chondroitinase ABC digestion of chondroitin sulphate containing an unsaturated hexuronate and 4-sulphated iV-acetyl galactosamine. (Hayes, A.J., Mitchell, R.E., Bashford, A., Reynolds, S., Caterson, B., and Hammond, C.L. ...
https://wiki.zfin.org/pages/diffpagesbyversion.action?pageId=102152983&selectedPageVersions=65&selectedPageVersions=66
FDA ADVISORY COMMITTEE REVIEWS SAVOR OUTCOMES STUDY RESULTS FOR ONGLYZA(R) (SAXAGLIPTIN) AND KOMBIGLYZE(R) XR (SAXAGLIPTIN AND...FDA ADVISORY COMMITTEE REVIEWS SAVOR OUTCOMES STUDY RESULTS FOR ONGLYZA(R) (SAXAGLIPTIN) AND KOMBIGLYZE(R) XR (SAXAGLIPTIN AND...
AstraZeneca today announced that the US Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) voted 13 to 1 (1 abstained; 15 total votes) that the results...
https://www.fiercepharma.com/pharma/fda-advisory-committee-reviews-savor-outcomes-study-results-for-onglyza-r-saxagliptin-and
Changes in Hydrophobic Surface of Collagen by Chondroitin Sulfate : Fluorescence Intensity Measurements with Bis...Changes in Hydrophobic Surface of Collagen by Chondroitin Sulfate : Fluorescence Intensity Measurements with Bis...
The improtant components of extracellular matrix(ECM) are collagen and chondroitin sulfate. The hydrophobic surface of collagen is one of the determining factors of diameter of collagen fiber and also is closely related to the aging phenomena. The controlling mechanism of the diameter of collagen fiber influenced by the interaction with chondroitin sulfate was evaluated using bis-ANS as a hydrophobic probe. Hydrophobic surface area of collagen molecule shielded by chondroitin sulfate was evaluated. Relative fluorescence intensity of collagen in thepresence of chondroitin sulfate was measured using bis-ANS as a hydrophobic probe. The fluorescence intensity decreased with the increase in chondroitin sulfate up to 3.8 chondroitin sulfate/collagen(mole/mole). Further increase in the ratio of chondroitin sulfate to collagen did not change the fluorescence intensity. Similar changes in the relative fluorescence intensity were observed
http://www.koreascience.or.kr/article/JAKO199511920153233.page
Chondroitin Sulfate Sell Offers Price/Photo/Factory - Sell Offers - Global-Trade-Center.comChondroitin Sulfate Sell Offers Price/Photo/Factory - Sell Offers - Global-Trade-Center.com
GTC Sell Offers column,To provide you with a full range ofChondroitin Sulfate information.Chondroitin Sulfate,Chondroitin Sulfate Price，Chondroitin Sulfate Images,Chondroitin Sulfate supplier，Chondroitin Sulfate factory，. As well as information about the model, parameters, specifications, brand, and price of Chondroitin Sulfate, the authority is reliable!
https://www.global-trade-center.com/SellOffers/k8253/
Unscramble chondroitin | Words unscrambled from letters chondroitin | Scrabble Word chondroitin | Words Made with the Letters...Unscramble chondroitin | Words unscrambled from letters chondroitin | Scrabble Word chondroitin | Words Made with the Letters...
Unscramble chondroitin, Unscramble letters chondroitin, Point value for chondroitin, Word Decoder for chondroitin, Word generator using the letters chondroitin, Word Solver chondroitin, Possible Scrabble words with chondroitin, Anagram of chondroitin
http://www.allscrabblewords.com/word-description/chondroitin
Polymers | Free Full-Text | Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous...Polymers | Free Full-Text | Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous...
Neuronal axons and their growth cones recognize molecular guidance cues within the local environment, forming axonal pathways to produce precise neuronal networks during nervous system development. Chondroitin sulfates (CS), carbohydrate chains on chondroitin sulfate proteoglycans, exhibit great structural diversity and exert various influences on axons and growth cones as guidance cues or their modulators; however, the relationship between their structural diversity and function in axonal guidance is not well known. To uncover the roles of CS in axonal guidance, artificially modified hybrid molecules: CS derivatives of biotinylated CS and lipid-derivatized CS, were used. The experiments with biotinylated CS suggest that the growing axons act on their environment, modifying CS, and rendering it more favorable for their growth. The experiments with lipid-derivatized CS demonstrated that growth cones distinguish types of CS with different unit contents and are likely to discriminate the structural
http://www.mdpi.com/2073-4360/5/1/254/notes
chondroitin sulfate - goodboychondroitin sulfate - goodboy
Chondroitin Sulfate Chondroitin is most often used to treat joint issues and pain. Chondroitin sulfate promotes healthy development and maintenance for the cartilage and tissue that align along the joints. In addition to improved mobility, chondroitin can also provide protection for the stomach, eyes, and bladder. Dogs
https://trygoodboy.com/pages/chondroitin-sulfate
research shows benefits of natural chondroitin | Regenexx Benefitsresearch shows benefits of natural chondroitin | Regenexx Benefits
Glucosamine and chondroitin have been the stepchildren of modern medicine for many years. While their use has skyrocketed due to a mass of supplements on the market, the average family doctor was much more likely to prescribe pharmaceutical concoctions such as Celebrex. In a study presented in November 2015 at a meeting of the American College of Rheumatology, chondroitin dramatically beat Celebrex in a head-to-head trial.. Chondroitin is a component of cartilage. The theory for taking it always has been simple-to provide the body with the building blocks of cartilage, and, just maybe, this would preserve or build cartilage. While the reality of how chondroitin works is a lot more complex, small studies using MRI have shown that chondoitin preserves cartilage. When given along with its cousin glucosamine, chondroitin is a potent anti-inflammatory. The two together even have been shown to lower cardiac risk factors.. The study presented to the American College of Rheumatology specifically looks ...
https://regenexxbenefits.com/research-shows-benefits-of-natural-chondroitin/
Bacteria act as aphrodisiac for the closest relatives of animals | Berkeley NewsBacteria act as aphrodisiac for the closest relatives of animals | Berkeley News
One possibility is that these animals need particular cues from environmental bacteria that are not being provided in the lab, she said.. After UC Berkeley graduate student Arielle Woznica discovered that these bacteria initiated swarming, they collaborated with Clardys lab to track down the trigger: a protein constantly secreted by the bacteria, which they dubbed EroS.. They showed that EroS is a chondroitinase, an enzyme that degrades a specific type of sulfated molecule found in the extracellular matrix of S. rosetta that was previously thought to be exclusive to animals. They also found that if this enzymatic function was inhibited, swarming did not occur, and that chondroitinases from other aquatic bacteria reproduced the aphrodisiacal effects. As the teams investigate how EroS works, theyre continuing to explore the interactions between bacteria and choanoflagellates.. As for implications for animals like humans and their bacterial partners, the so-called microbiome, King said that we ...
http://news.berkeley.edu/2017/09/01/bacteria-act-as-aphrodisiac-for-the-closest-relatives-of-animals/
RE: HaluronidaseRE: Haluronidase
Hylauronidase will digest the hyaluronic acid region of the molecule which will unmask the access to BMP antigens. There are three regions of the molecule which we digest for, chondroitin sulfate (chondroitinase), keratin sulfate (keratinase), and hyaluronic acid (hyaluronidase). This is a different concept than unwinding proteins which have been crosslinked by aldehydes, in this case the actual physical structure of the molecule is blocking the antigen site. With some of these digestions you must also include proteinase inhibitors to prevent loss of proteoglycans which may what you are interested in marking. We use proteinase inhibitors with chondroitinase ABC digestion when we are doing IHC for Aggrecan, for instance. Patsy Ruegg -----Original Message----- From: Renton, Lousie, Mrs [mailto:[email protected]] Sent: Tuesday, June 26, 2001 6:04 AM To: [email protected] Subject: Haluronidase Dear all A colleague of mine has an IHC method for bone morphogenic proteins (on FFPE ...
http://www.histosearch.com/histonet/Jun01A/RE.Haluronidase.html
Chondroitin Sulfate 600 mg - 120 CapsulesChondroitin Sulfate 600 mg - 120 Capsules
Chondroitin Sulfate 600 mg - 120 Capsules- Supports Healthy Joint Function* Supports Elasticity of Joint Tissues* Chondroitin Sulfate is a glycosaminoglycan and is a normal component of many body tissues including articular cartilage.* Our Chondroiti
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Chondroitin Sulfate 600 mg 600 mg 2 Bottles x 120 Capsules 40480 | Joint Support Supplements | Piping Rock Health...Chondroitin Sulfate 600 mg 600 mg 2 Bottles x 120 Capsules 40480 | Joint Support Supplements | Piping Rock Health...
Chondroitin Sulfate is a naturally-occurring compound found in the cartilage, bone, skin, cornea, and arterial walls, as well as tissues throughout the body. It plays an important role in the health, function, and mobility of joints, as well as the comfort and elasticity of joint tissues.** It also works with hyaluronic acid to support the shock-absorbing properties of aggrecan.**. Piping Rocks Chondroitin Sulfate supplements deliver 600 mg of this joint-nourishing nutrient in each serving. Adults take one (1) quick release capsule two to three times daily with meals for optimal nutritional support. It is important to note that, like glucosamine, it may take several weeks of supplementation before any noticeable difference is seen.. ...
https://www.pipingrock.com/joint-support-supplements/chondroitin-sulfate-600-mg-40480
Product information, instructions, health benefits, and usage for Chondroitin SulfateProduct information, instructions, health benefits, and usage for Chondroitin Sulfate
Chondroitin Sulfate list and information including what is Chondroitin Sulfate, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
https://www.allstarhealth.com/lj_c_b/chondroitin_sulfate/starchem_labs.htm
Product information, instructions, health benefits, and usage for Chondroitin SulfateProduct information, instructions, health benefits, and usage for Chondroitin Sulfate
Chondroitin Sulfate list and information including what is Chondroitin Sulfate, health benefits and usage indications. Find articles and product list for other top low-carb products, fat-burners, nutrition bars and shakes.
https://www.allstarhealth.com/lj_c_b/chondroitin_sulfate/labrada.htm?sort=relevance&pr=0-15
CHONDROITIN SULFATE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and ReviewsCHONDROITIN SULFATE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
Learn more about CHONDROITIN SULFATE uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain CHONDROITIN SULFATE.
https://www.webmd.com/vitamins/ai/ingredientmono-744/chondroitin-sulfate
Chondroitin Sulfate - FYZ PLANT EXTRACTChondroitin Sulfate - FYZ PLANT EXTRACT
As a professional Chondroitin sulfate manufacturer and supplier, FYZ supply Chondroitin sulfate powder for treating osteoarthritis joint pain.
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Chondroitin SulfateChondroitin Sulfate
Chondroitin Sulfate - Browse fuzing.com to find chondroitin sulfate sellers, suppliers, wholesalers, companies, manufacturers, exporters, factories.
https://www.fuzing.com/chondroitin-sulfate/l/662401b4-8bdc-84e6-d243-91f22dc793a8
An injectable and self-healing hydrogel with covalent cross-linking in vivo for cranial bone repair - Journal of Materials...An injectable and self-healing hydrogel with covalent cross-linking in vivo for cranial bone repair - Journal of Materials...
Current hydrogels based on chondroitin sulfate (ChS) generally lack the necessary strength and precise mechanical tunability. Addressing these limitations, covalent cross-linking has evolved to produce hydrogels with desirable properties. However, such a methodology always precludes injection and self-healin
http://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00776k
Chondroitin OverdoseChondroitin Overdose
It is not known what exactly to expect from a chondroitin overdose. However, as this eMedTV page discusses, an overdose is likely to cause stomach upset. This page covers other possible effects of an overdose on chondroitin, as well as treatment options.
http://arthritis.emedtv.com/chondroitin/chondroitin-overdose.html
Chondroitin sulfate and prostate cancerChondroitin sulfate and prostate cancer
Chondroitin is a common ingredient in arthritis supplements. Discover the disturbing link between chondroitin sulfate and prostate cancer and be educated.
https://greenlippedmusselbenefits.org/chondroitin-sulfate-and-prostate-cancer/
Chondroitin, 500mg - 90 capsChondroitin, 500mg - 90 caps
Each package contains 90 chondroitin capsules to support your daily diet. Our capsules contain 90 chondoitin sulphate which is naturally extracted from the purest bovine cartilage. Natural chondroitin With a chondroitin sulfate content of 90 From
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Pig to primate transplants show promise for diabetes - Healthcanal.com : Healthcanal.comPig to primate transplants show promise for diabetes - Healthcanal.com : Healthcanal.com
As part of the study, the researchers tried to boost insulin production in the macaques by performing a second transplant. Four weeks after transplanting the embryonic pig cells, they implanted adult insulin-producing pig islet cells into the kidneys of the macaques. The embryonic cells primed the monkeys immune system to accept the mature islet cells, without using anti-rejection drugs, but their glucose control did not continue to improve.. Hammerman. Hammerman suspects this may be because they did not transplant enough adult pig islet cells or that placing them in the kidney is not an optimal location. As a comparison, the researchers also transplanted adult pig islet cells into a control group of diabetic macaques that did not receive the earlier embryonic pig cell transplants. Not surprisingly, the macaques immune systems attacked the foreign cells and eventually rejected those cells all together.. The new study builds on earlier research in rats, reported by the same group last year in ...
https://www.healthcanal.com/metabolic-problems/23019-pig-to-primate-transplants-show-promise-for-diabetes.html
HAPPY PAWS CO - Roo & Chondroitin Sprinkle - Fetch ConnectionHAPPY PAWS CO - Roo & Chondroitin Sprinkle - Fetch Connection
Roo & Chondroitin Sprinkle No additives. No Fillers. No enhancers. No preservatives Made in Australia with 100% Aussie proteins Great for fussy pets Multiple health benefits Roo & Chondroitin sprinkle is a combination of chondroitin for the joints and low fat kangaroo meat. Great for those aching joints. This c
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Chondroitin Product in Supplement and VitaminsChondroitin Product in Supplement and Vitamins
Chondroitin sulfate is one of the major constituents of cartilage. Chondroitin sulfate consists of repeating chains of molecules called mucopolysaccharides
http://www.bayho.com/c/177
Source Naturals :: Chondroitin SulfateSource Naturals :: Chondroitin Sulfate
Chondroitin sulfate (CSA) is a mucopolysaccharide found in cartilage, tendons, and ligaments, where it is bound to proteins such as collagen and elastin. In our joints, it contributes to strength, flexibility and shock absorption. Current research indicates that supplemental CSA may help maintain proper joint function.
http://www.sourcenaturals.com/products/GP1068/
Chondroitin Sulfate Supplements | Benefits | Uses | Dosage | Piping Rock Health ProductsChondroitin Sulfate Supplements | Benefits | Uses | Dosage | Piping Rock Health Products
Chondroitin Sulfate is a vital part of joint cartilage that supports joint comfort. Piping Rock joint care vitamins are manufactured for peak quality.
https://pf.pipingrock.com/chondroitin-sulfate
Chondroitin Sulfate: Good for the Disc and MS! | Spine & Sports Rehab CenterChondroitin Sulfate: Good for the Disc and MS! | Spine & Sports Rehab Center
Spine & Sports Rehab Center shares the potentially beneficial effects of chondroitin sulfate for disc cartilage and now even multiple sclerosis!
https://www.docshay.com/doctor/chiropractor/chiropractic-Baton-Rouge-/nutrition-articles/chondroitin-sulfate-good-for-the-disc-and-ms
Chondroitin Sulfate | Hand Arthritis | Life ExtensionChondroitin Sulfate | Hand Arthritis | Life Extension
Researchers report the results of a trial which uncovered a benefit for supplementation with chondroitin sulfate in individuals with osteoarthritis of the hand.
http://www.lifeextension.com/newsletter/2011/9/chondroitin-sulfate-improves-hand-arthritis-in-clinical-trial/page-01
Chondroitin Sulfate Market: Leading Manufacturers Revenue, Type and Applications forecast to 2022 | MedgadgetChondroitin Sulfate Market: Leading Manufacturers Revenue, Type and Applications forecast to 2022 | Medgadget
HTF MI recently broadcasted a new study in its database that highlights the in-depth market analysis with future prospects of Chondroitin Sulfate market. T
https://www.medgadget.com/2018/01/chondroitin-sulfate-market-leading-manufacturers-revenue-type-and-applications-forecast-to-2022.html
Vitamin Shoppe Chondroitin Sulfate 500 mg Reviews and InformationVitamin Shoppe Chondroitin Sulfate 500 mg Reviews and Information
Chondroitin Sulfate 500 mg Reviews and other Reviews of Nutritional Supplements and Merchants Plus Related Resources Including a 2017 Buying Guide. Healthy Learning for Healthy Living.
http://www.nutritionaltree.com/reviews/joints-bones/chondroitin/vitamin-shoppe_chondroitin-sulfate-500-mg.aspx
寻找可应用于食品、饮料与营养保健品行业的Chondroitin Sulfate |搜索数据表，物质安全数据表或申请样品寻找可应用于食品、饮料与营养保健品行业的Chondroitin Sulfate |搜索数据表，物质安全数据表或申请样品
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https://www.ulprospector.com/zh-cn/asia/Food/Products/16688
Global Chondroitin Sulfate MarketGlobal Chondroitin Sulfate Market
Global Chondroitin Sulfate Market was valued US$ XX Bn in 2018 and is expected to reach US$ XX Bn by 2026, at CAGR of XX% during forecast period.
http://articlesnow4u.com/articles/6527/global-chondroitin-sulfate-market.php
Prostatic chondroitin sulfate is increased in patients with metastatic disease but does not predict survival outcome<...Prostatic chondroitin sulfate is increased in patients with metastatic disease but does not predict survival outcome<...
TY - JOUR. T1 - Prostatic chondroitin sulfate is increased in patients with metastatic disease but does not predict survival outcome. AU - Ricciardelli, Carmela. AU - Sakko, Andrew. AU - Stahl, Jurgen. AU - Tilley, Wayne. AU - Marshall, Villis. AU - Horsfall, David. PY - 2009. Y1 - 2009. M3 - Article. VL - 69. SP - 761. EP - 769. JO - The Prostate. JF - The Prostate. SN - 1097-0045. IS - 7. ER - ...
https://researchnow.flinders.edu.au/en/publications/prostatic-chondroitin-sulfate-is-increased-in-patients-with-metas
CHONDROITIN DISACCHARIDE STOCK SOLUTION(SH) 北京坛墨质检CHONDROITIN DISACCHARIDE STOCK SOLUTION(SH) 北京坛墨质检
坛墨质检标准物质中心为您提供各种规格的CHONDROITIN DISACCHARIDE STOCK SOLUTION(SH)批发供应，CHONDROITIN DISACCHARIDE STOCK SOLUTION(SH)的CAS号、标准值、价格均可在线咨询
https://www.gbw-china.com/info/180083682.html
Mad Cow Disease & Chondroitin - American ChondroitinMad Cow Disease & Chondroitin - American Chondroitin
Posted on Nov 18, 2014. Since its inception in 2001, Summit Nutritionals International ® has been the leader in manufacturing and delivering 100% USA made and 100% BSE free Chondroitin Sulfate to the world. Make Summit Nutritionals ® your source for 100% BSE Free bulk nutritional raw materials.. ...
http://americanchondroitin.com/mad-cow-disease-chondroitin-2/
Chondroitin | Memorial HealthChondroitin | Memorial Health
Learn more about Chondroitin at Memorial Health Supplement Forms/Alternate Names Chondroitin Sulfate Uses Principal Proposed Uses ...
https://memorialhealth.com/hl/?/21661/chondroitin
ChondroitinChondroitin
|p|Chondroitin occurs next to cartilage tissue in connective tissue, tendons and skin. In relatively small quantities, chondroitin is absorbed through anima
https://buxtrade.de/en/food-supplements/chondroitin
Collagen Chondroitin Vitamin C - Super Nature ProductsCollagen Chondroitin Vitamin C - Super Nature Products
Polysaccharide-Protein-Vitamin preparation Chondroitin: the dietary supplement chondroitin is the undervalued brother of the more famous
https://www.supernatureproducts.com/product/collagen-chondroitin-vitamin-c/
Buy Chondroitin Supplements - VitaminExpress Online ShopBuy Chondroitin Supplements - VitaminExpress Online Shop
Buy Chondroitin Supplements online at VitaminExpress and save. Guaranteed Quality. Free Shipping. Fast Delivery. Order Chondroitin now.
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ChondroitinChondroitin
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Doctors Best, Glucosamin Chondroitin MSM mit OptiMSM, 240 vegetarische Kapseln - askwebman.comDoctors Best, Glucosamin Chondroitin MSM mit OptiMSM, 240 vegetarische Kapseln - askwebman.com
Science-Based NutritionNahrungsergänzungsmittelUnterstützt die Gelenkgesundheit und -beweglichkeitGMO-frei/Glutenfrei/Ohne SojaGlucosamin Chondroitin MSM® von Doctors Best liefert drei wichtige Nährstoffe, die dabei helfen, Gelenke und Bindegewebe gesund zu halten: Glucosamin, Chondroitin und.... ...
https://askwebman.com/blog/2020/11/02/doctors-best-glucosamin-chondroitin-msm-mit-optimsm-240-vegetarische-kapseln/
DHC - Maintaining Elastic Chondroitin Healthy Vitali...DHC - Maintaining Elastic Chondroitin Healthy Vitali...
Help maintain the cartilage power of the body and help you maintain vitality. Solve the problem of insufficient joint support, supplement chondroitin, and return to the youthful running and jumping moments.
https://www.citiwide-online.com/products/dhc-maintaining-elastic-chondroitin-healthy-vitality-food-20-days-
Chondroitin Side Effects - Health HeartyChondroitin Side Effects - Health Hearty
Chondroitin is a chemical naturally present in the connective tissues of humans and animals. It is mainly used for the treatment of osteoarthritis. The following article provides information about the various side effects of this chemical.
https://healthhearty.com/chondroitin-side-effects
Glucosamin Chondroitin MSM | Ekilibrium.roGlucosamin Chondroitin MSM | Ekilibrium.ro
Cumpara rapid si simplu Glucosamin Chondroitin MSM. Produsul ajuta la mentinerea si refacerea integritatii structurale si functionale a articulatiilor.
http://www.ekilibrium.ro/articol/Produse/sub/Glucosamin_Chondroitin_MSM-1454.html
Chondroitin Sulfate + Vit D / Oleic / RerumChondroitin Sulfate + Vit D / Oleic / Rerum
|p|Ancient Purity is proud to present Keto Kerris product to the UK and Europe...|br /||span|Its the Rerum equivalent at less than 300th of the price. Kerri has helped hundreds of children lose their symptoms and much more.|/span||/p|
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CHONDROITIN SULFATE , 軟骨素硫酸（粉劑/膠囊） - GLADVET 葛萊芬 | ...CHONDROITIN SULFATE , 軟骨素硫酸（粉劑/膠囊） - GLADVET 葛萊芬 | ...
GLADVET 葛萊芬,獸醫師專用通路,提供獸醫師與飼主客製化的動物醫療保健品優質選擇 GLADVET，獸醫專業品牌，獸醫專屬，獸醫院通路 ...
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Multipower Power Pack Classic Carbohydrate-Protein Bar - Box with 24x 35gMultipower Power Pack Classic Carbohydrate-Protein Bar - Box with 24x 35g
Multipower ▶ The classic of all protein bars supplies you with 27 percent high-quality protein and important carbohydrates. ▶ Model: Box with 24x 35g
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Chondroitin-Glucosamine - Side Effects, Dosage, Interactions - Drugs - Everyday HealthChondroitin-Glucosamine - Side Effects, Dosage, Interactions - Drugs - Everyday Health
Chondroitin is a naturally occurring substance formed of sugar chains. Chondroitin is believed to help the body maintain fluid and flexibility in the joints.
https://www.everydayhealth.com/drugs/chondroitin-glucosamine
Chris Harris FuturesChris Harris Futures
Chondroitinase offers us hope in two ways; firstly it allows some nerve fibers to regenerate and secondly it enables other nerves to take on the role of those fibers that cannot be repaired ...
http://chrisharrisfutures.blogspot.com/2008/04/significant-breakthrough-in-treatment.html
List of MeSH codes (D08)List of MeSH codes (D08)
... chondroitinases and chondroitin lyases MeSH D08.811.520.241.700.350.500 - chondroitin lyases MeSH D08.811.520.241.700.350. ... chondroitinases and chondroitin lyases MeSH D08.811.277.352.827.180.175 - chondroitinsulfatases MeSH D08.811.277.352.827.180. ... chondroitin abc lyase MeSH D08.811.520.241.700.512 - heparin lyase MeSH D08.811.520.241.700.675 - hyaluronoglucosaminidase MeSH ... tyrosine phenol-lyase MeSH D08.811.520.232.300 - amidine-lyases MeSH D08.811.520.232.300.200 - adenylosuccinate lyase MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
Glycans are involved in RANTES binding to CCR5 positive as well as to CCR5 negative cellsGlycans are involved in RANTES binding to CCR5 positive as well as to CCR5 negative cells
... heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary ... Chondroitin Sulfates / pharmacology * Chondroitinases and Chondroitin Lyases * Glycosaminoglycans / metabolism * Heparin / ... heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary ... heparin or chondroitin sulfate), significantly inhibited RANTES binding. Such effects were not observed with truncated (10--68 ...
https://pubmed.ncbi.nlm.nih.gov/11342172/?dopt=Abstract
A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been...A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been...
Chondroitinases And Chondroitin Lyases. Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, ... Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate ... Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. ... Chondroitin Sulfates. Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of ...
https://www.bioportfolio.com/resources/trial/127701/A-Study-to-Evaluate-the-Long-Term-Effectiveness-of-Three-Anti-HIV.html
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill ChildrenSafety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children
Chondroitinases And Chondroitin Lyases. Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, ... Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate ... Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. ... Chondroitin Sulfates. Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of ...
https://www.bioportfolio.com/resources/trial/68266/Safety-and-Dose-Escalation-Study-of-Zinc-Supplementation-in-Critically-Ill-Children.html
Chondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides | SpringerLinkChondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides | SpringerLink
Chondroitin sulfate (CS) saccharides from cartilage tissues have potential application in medicine or as dietary supplements ... An improved methodology to produce Flavobacterium heparinum chondroitinases, important instruments for diagnosis of diseases. ... Chondroitin sulfate Chondroitin sulfate lyase Marine Arthrobacter sp. This is a preview of subscription content, log in to ... Chondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides. ...
https://link.springer.com/article/10.1007%2Fs10126-015-9629-9
Expression System for High Levels of GAG Lyase Gene Expression and Study of the hepA Upstream Region in Flavobacterium...Expression System for High Levels of GAG Lyase Gene Expression and Study of the hepA Upstream Region in Flavobacterium...
Purification of GAG lyases.Purification of the heparinases and chondroitinases from F. heparinum was described previously (11, ... The higher chondroitin sulfate A-degrading activity seen in strain FIBX6 grown in chondroitin sulfate A medium could not be ... Two chondroitinases from F. heparinum, chondroitinases AC (ChnA) and B (ChnB), were purified and characterized. It was shown ... Enzyme assay.Heparin-, heparan sulfate-, chondroitin sulfate A-, chondroitin sulfate C-, and dermatan sulfate-degrading ...
https://jb.asm.org/content/184/12/3242
Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by...Glycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by...
The identity of the different S-GAG was confirmed by degradation with specific lyases: chondroitinases B, AC (Seikagaku Kogyo ... CS: chondroitin sulphate.. Figure 2 Mass spectroscopy to identify chondroitin sulphate oligosaccharides. Chondroitin sulphate ... The substrate specificity of chondroitinases B, AC were CS A and C, chondroitin, and hyaluronic acid. The chondroitinase AC ... The products were compared with the standard of chondroitin-4-sulphated and chondroitin-6-sulphated products ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000400510&lng=en&tlng=en
Microvascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbitsMicrovascular effects of chondroitinase ABC and chymopapain. An in vivo experimental study on hamsters and rabbits
Animals, Cartilage, Cheek, Chondroitin Lyases, Chondroitinases and Chondroitin Lyases, Chymopapain, Cricetinae, Mesocricetus, ... Chondroitin Lyases,Chondroitinases and Chondroitin Lyases,Chymopapain,Cricetinae,Mesocricetus,Microcirculation,Microscopy,Mouth ...
https://lup.lub.lu.se/search/publication/d808ca95-9c7e-4268-bd52-0908aa0f04c1
Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A - Fingerprint -...Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A - Fingerprint -...
Fingerprint Dive into the research topics of Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their ... Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A. ...
https://einstein.pure.elsevier.com/en/publications/chromaffin-granule-and-pc12-cell-chondroitin-sulfate-proteoglycan-2/fingerprints/
Tuffaha, S. H.<...Tuffaha, S. H.<...
Chondroitinases and Chondroitin Lyases Medicine & Life Sciences * Peripheral Nerve Injuries Medicine & Life Sciences ...
https://jhu.pure.elsevier.com/en/persons/sami-tuffaha
FGF-2- and TGF-β1-Induced Downregulation of Lumican and Keratocan in Activated Corneal Keratocytes by JNK Signaling Pathway |...FGF-2- and TGF-β1-Induced Downregulation of Lumican and Keratocan in Activated Corneal Keratocytes by JNK Signaling Pathway |...
Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) ...
http://iovs.arvojournals.org/article.aspx?articleid=2187397
Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor...Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor...
Chondroitinases and Chondroitin Lyases. -. dc.subject.mesh. Chromatography, Gel. -. dc.subject.mesh. Cricetinae. - ... Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. ... Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor ... Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor ...
http://christie.openrepository.com/christie/handle/10541/85528
Ghosh, S.<...Ghosh, S.<...
Lokeshwar, V. B., Morera, D. S., Hasanali, S. L., Yates, T. J., Hupe, M. C., Knapp, J., Lokeshwar, S. D., Wang, J., Hennig, M. J. P., Baskar, R., Escudero, D. O., Racine, R. R., Dhir, N., Jordan, A. R., Hoye, K., Azih, I., Manoharan, M., Klaassen, Z. W. A., Kavuri, S. K., Lopez, L. E. & 2 others, Ghosh, S. & Lokeshwar, B. L., Jul 1 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 13, p. 3455-3467 13 p.. Research output: Contribution to journal › Article ...
https://augusta.pure.elsevier.com/en/persons/santu-ghosh
Find Research outputs - Manipal Academy of Higher Education, Manipal, IndiaFind Research outputs - Manipal Academy of Higher Education, Manipal, India
Onderzoeksoutput zoeken - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)Onderzoeksoutput zoeken - Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)
Wei-Ping Lee - Research Output - University of Texas Southwestern Medical CenterWei-Ping Lee - Research Output - University of Texas Southwestern Medical Center
Chondroitin Sulfate And Cancer - Chondroitin SulfateChondroitin Sulfate And Cancer - Chondroitin Sulfate
B. GalAG Lyase-Mediated Degradation of GAGs. Chondroitinases (Table VI) are produced in soil and intestinal bacteria. ... C. Chondroitinases from Pedobacter heparinus. Chondroitinase ABC from P. heparinus is a broad substrate specificity lyase that ... Chondroitin lyases have been isolated and characterized from a variety genera, most notably Pedobacter (Fethiere et al., 1999; ... has actually been found to comprise two distinct lyases, chondroitinases ABC I and II. Both enzymes cleave a wide variety of ...
https://www.clicktocurecancer.info/chondroitin-sulfate/info-ktl.html
Galsulfase - DrugBankGalsulfase - DrugBank
Carbon-Oxygen Lyases. *Chondroitinases and Chondroitin Lyases. *Chondroitinsulfatases. *Enzymes. *Enzymes and Coenzymes ... that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4- ...
https://www.drugbank.ca/drugs/DB01279
NAVER Academic > Search...NAVER Academic > Search...
Carbohydrates, analysis, Cell Differentiation, Cells, Cultured, Chondroitinases and Chondroitin Lyases, pharmacology, ...
https://academic.naver.com/search.naver?field=3&query=BIOCHEMICAL+JOURNAL+210%EA%B6%8C+3%ED%98%B8
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
chondroitin sulphate-dermatan sulphate hybrid (1) 1 Filter by. Remove filter. chondroitinases and chondroitin lyases - ... Chondroitinases and Chondroitin Lyases - metabolism , Sulfates - metabolism , Disaccharides - metabolism , Glycosaminoglycans ... Chondroitin sulphate , N-linked oligosaccharide , Site-directed mutagenesis , Tunicamycin , Chondroitin 4-sulphotransferase ( ... C4ST-1 (chondroitin 4-sulphotransferase-1) transfers sulphate to position 4 of N-acetylgalactosamine in chondroitin. We showed ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Chondroitin%204-sulphotransferase-1%20
Search | Global Index MedicusSearch | Global Index Medicus
Chondroitin Sulfates , Chondroitinases and Chondroitin Lyases , Dermatan Sulfate See more details. SEND TO:. Email ... Purification and utilization of chondroitinases AC, B and C from Flavobacterium in the study of proteoglycans the extracellular ...
https://search.bvsalud.org/gim/?lang=en&q=au:AGUIAR,+Jair+Adriano+Kopke+de
Search | Global Index MedicusSearch | Global Index Medicus
Chondroitinases and Chondroitin Lyases/isolation & purification , Chromatography/methods , Flavobacterium/enzymology , ... Chondroitin Sulfates/chemistry , Chondroitin Sulfates/isolation & purification , Culture Media , Dermatan Sulfate/chemistry , ... Chondroitinases AC and B were separated from each other and also from glucuronidases and sulfatases by hydrophobic interaction ... The purpose of the present study was to optimize the preparation of F. heparinum chondroitinases, which are very useful tools ...
https://search.bvsalud.org/gim/?lang=en&q=au:Aguiar,+J.A.K.
KEGG ENZYME: 4.2.2.19KEGG ENZYME: 4.2.2.19
The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic ... Inhibition of hyaluronidases and chondroitinases by fatty acids.. Journal. J Enzyme Inhib Med Chem 17:183-6 (2002). DOI:10.1080 ... Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum. ... This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required ...
https://www.genome.jp/dbget-bin/www_bget?ec:4.2.2.19
ExplorEnz: EC 4.2.2.19ExplorEnz: EC 4.2.2.19
chondroitin B lyase. Comments:. This is the only lyase that is known to be specific for dermatan sulfate as substrate. The ... Suzuki, K., Terasaki, Y. and Uyeda, M. Inhibition of hyaluronidases and chondroitinases by fatty acids. J. Enzyme 17 (2002) 183 ... chondroitin B lyase. Reaction:. Eliminative cleavage of dermatan sulfate containing (1→4)-β-D-hexosaminyl and (1→3)-β-D- ... The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic ...
https://www.enzyme-database.org/query.php?ec=4.2.2.19
Proteoglycans and GAG research | amsbioProteoglycans and GAG research | amsbio
GAG Oligosaccharides for Heparin, Hyaluronic Acid, Chondroitin Sulfate and Dermatan Sulfate. Disaccharide standards for ... GAG Degrading Enzymes including Chondroitinases (ABC, AC I and II,), heparinase / heparitinase family, Hyaluronidases, ... keratanases and new K5 heparan lyase (Technical Bulletin). *Chondroitinase ABC enzyme, Chondroitin Sulfate "stub antibodies" ... Monoclonal antibodies to Chondroitin Sulfate, Heparan Sulfate, Keratan Sulfate. *Recombinant Hyaluronic Acid Binding Protein ...
http://www.amsbio.com/Proteoglycans-Glycosaminoglycans.aspx
Recent progress on deep eutectic solvents in biocatalysis | Bioresources and Bioprocessing | Full TextRecent progress on deep eutectic solvents in biocatalysis | Bioresources and Bioprocessing | Full Text
2014), benzaldehyde lyase (Maugeri and Domínguez de María 2014) and phospholipase D (Yang and Duan 2016), also showed improved ... Chondroitinases ABCI. ChCl/Gly (1:2). Chondroitin. Improving thermal stability remarkably. Daneshjou et al. (2017) ... Daneshjou S, Khodaverdian S, Dabirmanesh B, Rahimi F, Daneshjoo S, Ghazi F, Khajeh K (2017) Improvement of chondroitinases ABCI ... Maugeri Z, Domínguez de María P (2014) Benzaldehyde lyase (BAL)-catalyzed enantioselective CC bond formation in deep-eutectic- ...
https://bioresourcesbioprocessing.springeropen.com/articles/10.1186/s40643-017-0165-5
Plus itPlus it
The incubations with chondroitin (Fig. 6A) showed a 13-fold upregulation of 4-O-activity in tumor tissue as compared with ... To this end, CS/DS was purified and extensively degraded into disaccharides by a mixture of chondroitinases ABC, AC-I, and B ... In both cases, the digest solutions were incubated at 37°C, and after 2 hours, another aliquot of lyases was added. ... Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells. Glycobiology 2009;19:735- ...
http://cancerres.aacrjournals.org/content/72/8/1943
Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells...Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells...
Lyase treatment was performed as described above.. The control and lyase-treated, labeled PGs were analyzed by SDS-PAGE as ... 2013). Biological functions of iduronic acid in chondroitin/dermatan sulfate. FEBS J. 280, 2431-2446. doi:10.1111/febs.12214. ... 3). Nitrous acid at low pH was used to degrade HS (Shively and Conrad, 1976), and chondroitinases that are specific for DS ( ... Lyase treatment. Proteoglycans were treated for 2 h at 37°C with 10 mIU chondroitinase ABC (Sigma) in 20 µl ammonium acetate pH ...
http://dmm.biologists.org/content/9/6/607
Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts - Deangelis, Paul L.Methods of expressing gram-negative glycosaminoglycan synthase genes in gram-positive hosts - Deangelis, Paul L.
... larger molecular weight chondroitin made be degraded with specific chondroitinases to make lower molecular weight chondroitin. ... or chondroitin-like based on the observation that their capsules are degraded by Flavobacterium chondroitin AC lyase. After ... and that is associated with the ability of prokaryotes to produce chondroitin or a "chondroitin like" polymer or a chondroitin ... and capital in order to convert sulfated chondroitin into unsulfated or desulfated chondroitin. Once the chondroitin is ...
http://www.freepatentsonline.com/y2007/0281342.html
ProteoglycansSulfatesHeparanEnzymeGlycosaminoglycansChnBGAGsRecombinantHeparinum chondroitinasesResiduesEnzymesOligosaccharidesIsolated and characterizedCartilageFlavobacteriumDisaccharideArthrobacterHyaluronidasesGenesDerivativesActiveRegionSideActivity
Proteoglycans4
  • Fingerprint Dive into the research topics of 'Chromaffin granule and PC12 cell chondroitin sulfate proteoglycans and their relation to chromogranin A'. Together they form a unique fingerprint. (elsevier.com)
  • Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. (aacrjournals.org)
  • We demonstrate that DS-epi1 is important for the generation of isolated iduronic acid residues in chondroitin sulfate (CS)/DS proteoglycans in early Xenopus embryos. (biologists.org)
  • Glycosaminoglycans (GAGs), such as DS, chondroitin sulfate (CS) and heparan sulfate (HS), are side chains of repeating disaccharides, which are covalently attached to distinct core proteins in the Golgi complex to form cell surface and extracellular matrix proteoglycans (PGs) ( Iozzo and Schaefer, 2015 ). (biologists.org)
Sulfates3
  • Bali JP, Cousse H, Neuzil E (2001) Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system. (springer.com)
  • The purpose of the present study was to optimize the preparation of F. heparinum chondroitinases, which are very useful tools for the identification and structural characterization of chondroitin and dermatan sulfates. (bvsalud.org)
  • Characterization of oligosaccharides from the chondroitin/dermatan sulfates. (genome.jp)
Heparan4
  • We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells. (nih.gov)
  • Expressions of heparan sulphate, chondroitin sulphate, dermatan sulphate and their fragments were analyzed by electrospray ionization mass spectrometry, with the technique for extraction and quantification of glycosaminoglycans after proteolysis and electrophoresis. (scielo.br)
  • Neoplastic tissues showed greater amounts of chondroitin sulphate and dermatan sulphate compared to non-neoplastic tissues, while heparan sulphate was decreased in neoplastic tissues. (scielo.br)
  • ( 5 , 8 , 9 ) Chondroitin sulfate (CS) and dermatan sulfate (DS), both galactosaminoglycans, and heparan sulfate (HS), a glycosaminoglycan, are S-GAG involved in these biological events. (scielo.br)
Enzyme6
  • ChoA1 was defined as an AC-type enzyme as it degraded chondroitin sulfate A, C, and hyaluronic acid. (springer.com)
  • As the recombinant chondroitin sulfate lyase (designated as ChoA1R) degraded chondroitin sulfate efficiently compared to a benchmark enzyme, it may be used for the production of chondroitin sulfate disaccharides for the food industry or health-promoting products. (springer.com)
  • Chondroitinase ABC from P. heparinus is a broad substrate specificity lyase that acts on a variety of GAGs, including C4S, C6S, DS, chondroitin, chondroitin D and E. The enzyme is unable to catalyze the depolymerization of hyaluronate, heparin and HS, or KS. (clicktocurecancer.info)
  • It has a molecular weight in excess of 70 kDa and an optimal activity temperature of 30°C. The enzyme is fully active against DS, which is unusual for cABC lyases generally. (clicktocurecancer.info)
  • Chondroitinase AC (EC 4.2.2.5) from P. heparinus is a 75-kDa enzyme that acts on C4S, C6S, chondroitin, and hyaluronate (Fig. 6) (Huang et al. (clicktocurecancer.info)
  • It was shown that ChnA is a 75-kDa enzyme degrading both chondroitin sulfate A and C and that ChnB is a 55-kDa enzyme degrading only chondroitin sulfate B ( 11 ). (asm.org)
Glycosaminoglycans1
  • Baici A, Horler D, Moser B, Hofer HO, Fehr K, Wagenhauser FJ (1992) Analysis of glycosaminoglycans in human serum after oral-administration of chondroitin sulfate. (springer.com)
ChnB1
  • Two chondroitinases from F. heparinum , chondroitinases AC (ChnA) and B (ChnB), were purified and characterized. (asm.org)
GAGs1
  • Pretreating the cells with neuraminidase, heparitinase, chondroitinase or adding soluble glycans such as mannan or GAGs (heparin or chondroitin sulfate), significantly inhibited RANTES binding. (nih.gov)
Recombinant1
  • 2. The recombinant host cell of claim 1, wherein the purified nucleic acid segment encodes the Pasteurella multocida chondroitin synthase of SEQ ID NO:2. (freepatentsonline.com)
Heparinum chondroitinases1
  • Aguiar JA, Lima CR, Berto AGA, Michelacci YM (2003) An improved methodology to produce Flavobacterium heparinum chondroitinases, important instruments for diagnosis of diseases. (springer.com)
Residues2
  • Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. (bioportfolio.com)
  • It is a lysosomal hydrolase that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4-sulfate and dermatan sulfate. (drugbank.ca)
Enzymes2
  • It synthesizes five enzymes, three heparinases, and two chondroitinases that degrade heparin and acidic mucoheteropolysaccharides with sulfate groups from various animal tissues and uses them as sole sources of carbon, nitrogen, and energy ( 6 , 11 , 17 ). (asm.org)
  • Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium heparinum. (genome.jp)
Oligosaccharides1
  • The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery. (genome.jp)
Isolated and characterized1
  • Chondroitin lyases have been isolated and characterized from a variety genera, most notably Pedobacter (Fethiere et al. (clicktocurecancer.info)
Cartilage1
  • Chondroitin sulfate (CS) saccharides from cartilage tissues have potential application in medicine or as dietary supplements due to their therapeutic bioactivities. (springer.com)
Flavobacterium2
  • Flavobacterium heparinum is a soil bacterium that produces several mucopolysaccharidases such as heparinase, heparitinases I and II, and chondroitinases AC, B, C and ABC. (bvsalud.org)
  • Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum. (genome.jp)
Disaccharide2
  • Bakalash S, Rolls A, Lider O, Schwartz M (2007) Chondroitin sulfate-derived disaccharide protects retinal cells from elevated intraocular pressure in aged and immunocompromised rats. (springer.com)
  • Disaccharide standards for Chondroitin/Dermatan Sulfate and Heparin (including Disaccharides with N-unsubstituted Amine ). (amsbio.com)
Arthrobacter2
Hyaluronidases1
  • Inhibition of hyaluronidases and chondroitinases by fatty acids. (genome.jp)
Genes1
  • Following assembly and annotation, an orf, annotated as family 8 polysaccharide lyase genes, was identified, encoding an amino acid sequence with a similarity to CS lyases according to NCBI blastX. (springer.com)
Derivatives1
  • Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. (bioportfolio.com)
Active1
  • 9. The method of claim 8 wherein, in the step of providing a purified nucleic acid segment encoding an enzymatically active Pasteurella chondroitin synthase, the purified nucleic acid segment encodes the Pasteurella multocida chondroitin synthase of SEQ ID NO:2. (freepatentsonline.com)
Region1
  • In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. (genome.jp)
Side1
  • 1986). One should note that although lyases can only cleave linkages on the nonreducing side of uronic acid, the hydrolases have no such limitation and can cleave either bond. (clicktocurecancer.info)
Activity2
  • Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity. (openrepository.com)
  • Other cABC lyases have DS activities under 40% of their C4S activity (Ernst et al. (clicktocurecancer.info)