Chondroitin Sulfates
Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
Chondroitin
Glycosaminoglycans
Chondroitinases and Chondroitin Lyases
Dermatan Sulfate
Chondroitin Lyases
Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.
Chondroitin ABC Lyase
Chondroitin Sulfate Proteoglycans
Heparitin Sulfate
Electrophoresis, Cellulose Acetate
Hyaluronic Acid
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Polysaccharide-Lyases
Hyaluronoglucosaminidase
Cartilage
Sulfotransferases
Cattle
Keratan Sulfate
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Sulfuric Acids
Uronic Acids
Iduronic Acid
Oligosaccharides
Versicans
Carbohydrate Sequence
Heparin Lyase
An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Phosphoadenosine Phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.
Sharks
Aggrecans
Heparan Sulfate Proteoglycans
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
N-Acetylgalactosaminyltransferases
Extracellular Matrix Proteins
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Chromatography, Gel
Steryl-Sulfatase
Sulfur Radioisotopes
Glucuronates
Glucuronic Acid
Chromatography, Ion Exchange
Distribution of chondroitin sulfate in cartilage proteoglycans under associative conditions. (1/1490)
Proteoglycan aggregates and proteoglycan subunits were extracted from bovine articular cartilage with guanidine-HC1 folowed by fractionation by equilibrium centrifugation in cesium chloride density gradients. The distribution of chondroitin sulfates (CS) in the cartilage proteoglycans was studied at the disaccharide level by digestion with chondroitinases. In the proteoglycan aggregate fraction, it was observed that the proportion of 4-sulfated disaccharide units to total CS increased from the bottom to the top fractions, whereas that of 6-sulfated disaccharide units was in the reverse order. Thus, the ratio of 4-sulfated disaccharide units to 6-sulfated disaccharide units increased significantly with decreasing density. The proportion of non-sulfated disaccharide units to total CS tended to increase with increasing density. These data indicate a polydisperse distribution of CS chains, under the conditions used here, in proteoglycan aggregates from bovine articular cartilage. (+info)Identification and characterization of ligands for L-selectin in the kidney. II. Expression of chondroitin sulfate and heparan sulfate proteoglycans reactive with L-selectin. (2/1490)
Ligands for the leukocyte adhesion molecule L-selectin are expressed not only in lymph node high endothelial venules (HEV) but also in the renal distal tubuli. Here we report that L-selectin-reactive molecules in the kidney are chondroitin sulfate and heparan sulfate proteoglycans of 500-1000 kDa, unlike those in HEV bearing sialyl Lewis X-like carbohydrates. Binding of L-selectin to these molecules was mediated by the lectin domain of L-selectin and required divalent cations. Binding was inhibited by chondroitinase and/or heparitinase but not sialidase. Thus, L-selectin can recognize chondroitin sulfate and heparan sulfate glycosaminoglycans structurally distinct from sialyl Lewis X-like carbohydrates. (+info)Action of chondroitinases. II. Numerical calculation of the degree of multiple attack. (3/1490)
Further investigation was carried out on the action patterns of two chondroitinase-AC [EC 4.2.2.5.] preparations obtained from Arthrobacter aurescens and Flavobacterium heparinum. To infer the action patterns of the chondroitinases, we proposed a new method for the calculation of the degree of multiple attack, based on the concept established by Robyt and French ((1967) Arch. Biochem. Biophys. 122, 8-16). It was shown that the degree of multiple attack (DM) is represented by the ratio of the initial velocity of number-average degree of scission to that of viscosity-average degree of scission. By this method, DM for A-Chase was estimated to be 3.03 and for F-chase, 1.31. (+info)Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (4/1490)
A partial-length human cDNA with a predicted amino acid sequence homologous to a previously described heparan sulfate iduronyl 2-sulfotransferase (Kobayashi, M., Habuchi, H., Yoneda, M., Habuchi, O., and Kimata, K. (1997) J. Biol. Chem. 272, 13980-13985) was obtained by searching the expressed sequence-tagged data bank. Northern blot analysis was performed using this homologous cDNA as a probe, which demonstrated ubiquitous expression of messages of 5.1 and 2.0 kilobases in a number of human tissues and in several human cancer cell lines. Since the human lymphoma Raji cell line had the highest level of expression, it was used to isolate a full-length cDNA clone. The full-length cDNA was found to contain an open reading frame that predicted a type II transmembrane protein composed of 406 amino acid residues. The cDNA in a baculovirus expression vector was expressed in Sf9 insect cells, and cell extracts were then incubated together with 3'-phosphoadenosine 5'-phospho[35S]sulfate and potential glycosaminoglycan acceptors. This demonstrated substantial sulfotransferase activity with dermatan sulfate, a small degree of activity with chondroitin sulfate, but no sulfotransferase activity with desulfated N-resulfated heparin. Analysis of [35S]sulfate-labeled disaccharide products of chondroitin ABC, chondroitin AC, and chondroitin B lyase treatment demonstrated that the enzyme only transferred sulfate to the 2-position of uronyl residues, which were preponderantly iduronyl residues in dermatan sulfate, but some lesser transfer to glucuronyl residues of chondroitin sulfate. (+info)Multiple mechanisms contribute to the avoidance of avian epidermis by sensory axons. (5/1490)
In birds, sensory innervation of skin is restricted to dermis, with few axons penetrating into the epidermis. This pattern of innervation is maintained in vitro, where sensory neurites avoid explants of epidermis but grow readily on dermis. We have used this coculture paradigm to investigate the mechanisms that impede innervation of avian epidermis. The lack of epidermal innervation in birds has been attributed to diffusible chondroitin sulfate proteoglycans (CSPGs) secreted by the epidermis, although direct experimental evidence is weak. We found that elimination of CSPG function with either chondroitinase or neutralizing antibodies did not promote growth of DRG neurites onto epidermis in vitro, indicating that CSPGs alone are not responsible for preventing epidermal innervation. Moreover, the failure of sensory neurites to invade epidermis is not due exclusively to soluble chemorepulsive factors, since sensory neurites also avoid dead epidermis. This inhibition can be overridden, however, by coating epidermis with the growth-promoting molecule laminin, but only if the tissue is killed first. Epidermal innervation of laminin-coated epidermis is even more robust when CSPGs are also eliminated. Thus, the absence of growth-promoting or permissive molecules, such as laminin, may contribute to the failure of sensory neurites to invade avian epidermis. Together these results show that the inhibitory character of avian epidermis is complex. Cell- or matrix-associated CSPGs clearly contribute to the inhibition, but are not solely responsible. (+info)Infectious laryngotracheitis virus, an alpha herpesvirus that does not interact with cell surface heparan sulfate. (6/1490)
Among the alpha herpesviruses studied to date, the initial stage of wild-type virus attachment involves an interaction between virally encoded structural envelope glycoproteins (predominantly glycoprotein C) and cell surface heparan sulfate proteoglycans. An analysis of the infectious laryngotracheitis virus (ILTV) glycoprotein C and glycoprotein B sequences suggested that these proteins lacked consensus heparin-binding domains. This indicated that ILTV might attach to its host cell in a heparan-independent manner, distinct from other alpha herpesviruses. The infectivity of two ILTV strains, a tissue-culture-adapted vaccine strain and a virulent field challenge strain, were found to be insensitive to the presence of exogenous heparin or chondroitin. Furthermore, infectivity was retained in chicken embryonic liver cells treated with heparinase. However, 4 degrees C attachment studies and penetration studies in the presence of citrate buffer clearly demonstrated that ILTV attaches stably to and effectively penetrates chicken embryonic liver cells. Consequently, ILTV represents an alpha herpesvirus whose initial attachment step does not involve interactions with heparan or chondroitin sulfate containing proteoglycans. (+info)The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1. (7/1490)
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction. (+info)DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage. (8/1490)
DSD-1-PG is a chondroitin sulfate proteoglycan (CSPG) expressed by glial cells that can promote neurite outgrowth from rat embryonic mesencephalic (E14) and hippocampal (E18) neurons, an activity that is associated with the CS glycosaminoglycans (GAGs). Further characterization of DSD-1-PG has included sequencing of peptides from the core protein and the cloning of the corresponding cDNA using polyclonal antisera against DSD-1-PG to screen phage expression libraries. On the basis of these studies we have identified DSD-1-PG as the mouse homolog of phosphacan, a neural rat CSPG. Monoclonal antibodies 3H1 and 3F8 against carbohydrate residues on rat phosphacan recognize these epitopes on DSD-1-PG. The epitopes of the antibodies, L2/HNK-1 and L5/Lewis-X, which have been implicated in functional interactions, are also found on DSD-1-PG. Although DSD-1-PG has previously been shown to promote neurite outgrowth, its upregulation after stab wounding of the CNS and its localization in regions that are considered boundaries to axonal extension suggested that it may also have inhibitory functions. Neonatal dorsal root ganglion (DRG) explants grown on a rich supportive substrate (laminin) with and without DSD-1-PG were strikingly inhibited by the proteoglycan. The inhibitory effects of DSD-1-PG on the DRG explants were not relieved by removal of the CS GAGs, indicating that this activity is associated with the core glycoprotein. The neurite outgrowth from embryonic hippocampal neurons on laminin was not affected by the addition of DSD-1-PG. This indicates that DSD-1-PG/mouse phosphacan can have opposing effects on the process of neurite outgrowth dependent on neuronal lineage. (+info)
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Chondroitin sulfate proteoglycan
... s (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. ... Chondroitin sulfate proteoglycans are composed of a core protein and a sugar side chain. The core protein is generally a ... Chondroitin sulfate proteoglycans have been implicated in Alzheimer's disease, stroke, and epilepsy. The two primary markers of ... Galtrey, C. M.; Fawcett, J. W. (2007). "The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the ...
Chondroitin sulfate ABC lyase
... may refer to: Chondroitin ABC lyase, an enzyme Chondroitin-sulfate-ABC exolyase, an enzyme ... Chondroitin-sulfate-ABC endolyase, an enzyme This disambiguation page lists articles associated with the title Chondroitin ... sulfate ABC lyase. If an internal link led you here, you may wish to change the link to point directly to the intended article ...
Chondroitin sulfate
"Chondroitin sulfate B" is an old name for dermatan sulfate, and it is no longer classified as a form of chondroitin sulfate. ... Although the name "chondroitin sulfate" suggests a salt with a sulfate counter-anion, this is not the case, as sulfate is ... Furthermore, marine chondroitin sulfate chains tend to be longer, with molecular weight of up to 70 kDa in chondroitin sulfate ... Chondroitin sulfate is not metabolized by cytochrome P450. The effect of chondroitin sulfate in people with osteoarthritis is ...
Chondroitin-sulfate-ABC exolyase
... chondroitin sulfate ABC lyase (ambiguous), ChS ABC lyase (ambiguous), chondroitin sulfate ABC exoeliminase, chondroitin sulfate ... The enzyme chondroitin-sulfate-ABC exolyase (EC 4.2.2.21) catalyzes the following process: Exolytic removal of Δ4-unsaturated ... Suzuki S; Hashimoto, N; Mochizuki, H; Kato, F; Makiguchi, Y; Horie, K; Suzuki, S (1997). "Two distinct chondroitin sulfate ABC ... The systematic name of this enzyme class is chondroitin-sulfate-ABC exolyase. Other names in common use include chondroitinase ...
Chondroitin-sulfate-ABC endolyase
... chondroitin ABC lyase (ambiguous), chondroitin sulfate ABC lyase (ambiguous), ChS ABC lyase (ambiguous), chondroitin sulfate ... The enzyme chondroitin-sulfate-ABC endolyase (EC 4.2.2.20) catalyzes the following process: Endolytic cleavage of (1→4)-β- ... Suzuki S; Hashimoto, N; Mochizuki, H; Kato, F; Makiguchi, Y; Horie, K; Suzuki, S (1997). "Two distinct chondroitin sulfate ABC ... The systematic name of this enzyme class is chondroitin-sulfate-ABC endolyase. Other names in common use include chondroitinase ...
Galactosylxylosylprotein 3-beta-galactosyltransferase
Schwartz NB, Roden L (1975). "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases ... This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, ... Robinson JA, Robinson HC (1985). "Initiation of chondroitin sulphate synthesis by beta-D-galactosides Substrates for ...
Osteoarthritis
... recommends glucosamine sulfate and chondroitin sulfate for knee osteoarthritis. Its use as a therapy for osteoarthritis is ... Chondroitin Sulfate Concentration and Chain Length, Water, and Ash Content". The Journal of Clinical Investigation. 45 (7): ... Vangsness CT, Spiker W, Erickson J (January 2009). "A review of evidence-based medicine for glucosamine and chondroitin sulfate ... A difference may exist between glucosamine sulfate and glucosamine hydrochloride, with glucosamine sulfate showing a benefit ...
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
Helting T, Roden L (1969). "Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate ... This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, ...
B3GAT1
Pedersen LC, Tsuchida K, Kitagawa H, Sugahara K, Darden TA, Negishi M (November 2000). "Heparan/chondroitin sulfate ...
Xylosylprotein 4-beta-galactosyltransferase
Schwartz NB, Roden L (1975). "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases ... This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, ...
CHPF
Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene. GRCh38: Ensembl release 89: ... 2003). "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous ... "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization ... "Entrez Gene: CHPF chondroitin polymerizing factor". Human CHPF genome location and CHPF gene details page in the UCSC Genome ...
CHSY1
Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene. CHSY1 synthesizes chondroitin sulfate ... 2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711-25. doi:10.1074 ... "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization ... Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. ...
Protein xylosyltransferase
This enzyme participates in the biosynthesis of chondroitin sulfate and glycan structures. XYLT1 XYLT2 Xylosyltransferase ... "Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase". J. Biol. Chem. 247 ( ...
Chondroitin-glucuronate 5-epimerase
This enzyme participates in chondroitin sulfate biosynthesis. Malmstrom A, Aberg L (1982). "Biosynthesis of dermatan sulphate. ... In enzymology, a chondroitin-glucuronate 5-epimerase (EC 5.1.3.19) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is chondroitin-D-glucuronate 5-epimerase. Other names in common use include ... polyglucuronate 5-epimerase, dermatan-sulfate 5-epimerase, urunosyl C-5 epimerase, and chondroitin D-glucuronosyl 5-epimerase. ...
CSPG4
Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial ... "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4". Nishiyama A, Dahlin KJ, Prince JT, Johnstone SR, Stallcup WB (July 1991 ... Iida J, Meijne AM, Oegema TR, Yednock TA, Kovach NL, Furcht LT, McCarthy JB (March 1998). "A role of chondroitin sulfate ... Iida J, Pei D, Kang T, Simpson MA, Herlyn M, Furcht LT, McCarthy JB (June 2001). "Melanoma chondroitin sulfate proteoglycan ...
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Chondroitin B lyase
The enzyme chondroitin B lyase (EC 4.2.2.19) catalyzes the following process: Eliminative cleavage of dermatan sulfate ... "Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced ... Genes Coding for the Chondroitin Sulfate-Degrading Enzymes Chondroitinase AC and Chondroitinase B, Respectively, from ... The systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ...
Chondroitin AC lyase
Other names in common use include chondroitinase (ambiguous), chondroitin sulfate lyase, chondroitin AC eliminase, chondroitin ... "Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced ... The enzyme chondroitin AC lyase (EC 4.2.2.5) catalyzes the chemical reaction Eliminative degradation of polysaccharides ... The systematic name of this enzyme class is chondroitin AC lyase. ...
Heparan sulfate
The antibody binds heparan sulfate, not chondroitin sulfate. The binding of HS20 to heparan sulfate requires sulfation at both ... The pathways for HS/heparin or chondroitin sulfate (CS) and dermatan sulfate (DS) biosynthesis diverge after the formation of ... "Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5". ... Duncan MB, Chen J, Krise JP, Liu J (March 2004). "The biosynthesis of anticoagulant heparan sulfate by the heparan sulfate 3-O- ...
ChGn
"Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage". ... "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N- ... Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene. A form ... and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate ...
B3GAT3
2000). "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I". J. Biol. Chem. 275 ...
CD97
... chondroitin sulfate B with the fourth EGF-like domain; α5β1 and αvβ3 integrins with an RGD downstream the EGF-like domains; and ...
Heparinoid
Chondroitin sulfate shows slightly less biological activity than dermatan sulfate, and is composed of O-sulfated N-acetyl-D- ... Current USP standards for heparin limit levels of contamination with dermatan, chondroitin, and over-sulfated chondroitin ... Alginic acid functions as a heparinoid when it is sulfated. Pentosan from the bark of Fagus sylvatica, when sulfated, acts with ... N-sulfate, and O-sulfate groups in these uronic acids can vary, as can the branching patterns of the chain. This generates an ...
Maroteaux-Lamy syndrome
ARSB breaks down dermatan sulfate and chondroitin sulfate. Because people with MPS-VI lack the ability to break down these GAGs ... "A New Dysostosis with Urinary Elimination of Chondroitin Sulfate B". Presse Med (in French). 71: 1849-52. PMID 14091597. Cary, ... A urinalysis will show elevated levels of dermatan sulfate in the urine. A blood sample may be taken to assess the level of ...
Artificial cartilage
The most common GAGs are chondroitin sulfate and keratin sulfate. Proteoglycans attach to a central chain, usually hyaluronic ...
Linda Hsieh-Wilson
Specifically, her work with chondroitin sulfate (CS) and heparan sulfate (HS), the two most common glycosaminoglycans in the ... "A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth" (PDF). Journal of the American Chemical Society. 126 (25 ... Glycosaminoglycans are heterogeneously sulfated oligosaccharides that are very important in nervous system development, spinal ... Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans ...
Glucuronylgalactosylproteoglycan 4-b-N-acetylgalactosaminyltransferase
... and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate ... "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of ... Uyama T, Kitagawa H, Tamura Ji J, Sugahara K (March 2002). "Molecular cloning and expression of human chondroitin N- ... uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I, UDP-N-acetyl-D-galactosamine:D-glucuronyl-1 ...
NG2 proteoglycan
The core NG2 molecule is approximately 300 kDa and the addition of at least one chondroitin sulfate molecule results in a ... "Chondroitin sulphate proteoglycans: inhibitory components of the glial scar." Prog Brain Res. 2001;132:611-9. PMID 11545024. ... "NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and ... "Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury." J. Neurosci. 1994 Aug;14(8):4716-30. PMID ...
Dermatan 4-sulfotransferase
Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K (July 2006). "Chondroitin sulfate/dermatan sulfate hybrid chains in the ... Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (September 2003). "Specificities of three distinct human chondroitin/ ... This enzyme catalyses the following chemical reaction 3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine ⇌ {\ ... "Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate". Glycobiology. 19 (11 ...
CSPG5
Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene. CSPG5 has been shown to interact ... "Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)". Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; ... 2006). "Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate ... a neural transmembrane chondroitin sulfate proteoglycan with an EGF module". Neurosci Res. 32 (4): 313-22. doi:10.1016/S0168- ...
ATC code M01
M01AX18 Feprazone M01AX21 Diacerein M01AX22 Morniflumate M01AX23 Tenidap M01AX24 Oxaceprol M01AX25 Chondroitin sulfate M01AX26 ...
HAPLN1
"A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan ...
Methylsulfonylmethane
"Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A ... Two other studies investigated the effects of MSM in combination with glucosamine and chondroitin (GC) on joint function. In ...
CHST14
... human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate ... Dermatan sulfate is essential to extracellular matrix formation and is found in extensively in skin, tendons, cartilage, and ... Penc SF, Pomahac B, Winkler T, Dorschner RA, Eriksson E, Herndon M, Gallo RL (October 1998). "Dermatan sulfate released after ... Dermatan 4-O-sulfotransferase enzymatically transfers an active sulfate to position 4 of N-acetyl-D-galactosamine residues of ...
Bacteroides caccae
They do grow on host-derived glycans like neutral mucin O-glycans, chondroitin sulfate, and hyaluronic acid. The ...
Endogenous regeneration
... inhibitory axon guidance molecules and chondroitin sulfate proteoglycans. Inhibitory action of such factors may be a protection ...
Human skeleton
Chondroitin sulfate is a sugar made up primarily of oxygen and carbon. Bone cells release a hormone called osteocalcin, which ... However, bones are not entirely made of calcium, but a mixture of chondroitin sulfate and hydroxyapatite, the latter making up ...
Critical period
Ye Q, Miao QL (August 2013). "Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan ... Perineuronal nets (PNNs) are structures in the extracellular matrix formed by chondroitin sulfate proteoglycans, hyaluronan, ...
P-selectin
One of the sulfated ligands is chondroitin sulfate, a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has ... "Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines". Int. J. Cancer. 120 ... Among them, the inhibitory activity of semisynthetic sulfated tri mannose C-C-linked dimers (STMCs) to P-selectin was shown by ... Borsig L, Vlodavsky I, Ishai-Michaeli R, Torri G, Vismara E (May 2011). "Sulfated hexasaccharides attenuate metastasis by ...
Sulfotransferase
HS2ST1 heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST4, HS3ST5, HS3ST6 heparan sulfate 6-O- ... TPST2 uronyl-2-sulfotransferase Estrone sulfotransferase Chondroitin 4-sulfotransferase other: SULT1A1, SULT1A2, SULT1A3, ... the product is a sulfate (R-OSO3−), whereas an amine leads to a sulfamate (R-NH-SO3−). Both reactive groups for a sulfonation ...
Lacritin
... and an N-terminal chondroitin sulfate chain (likely also binds to the cationic face) appear to contribute to binding. Point ... Yet, long heparan sulfate chains interfere with lacritin binding. Since syndecans are always decorated with heparan sulfate, ... Exposed 3-O sulfated groups on heparanase-cleaved heparan sulfate (that likely interacts with the cationic face of lacritin's C ... syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel ...
Granulocyte
Granule contents of basophils are abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor ...
Chondroitin 4-sulfotransferase
... chondroitin 4'-sulfate Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two ... III Mechanism of sulfation of chondroitin and chondroitin sulfate A". J. Biol. Chem. 235: 274-276. PMID 13835881. Portal: ... This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate ... The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. ...
MMP16
Iida J, Pei D, Kang T (2001). "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human ...
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
This enzyme is also called chondroitin glucuronyltransferase II. This enzyme participates in chondroitin sulfate biosynthesis ... "Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N ... DeAngelis PL, Padgett-McCue AJ (2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella ... "Molecular cloning and expression of a human chondroitin synthase". J. Biol. Chem. 276 (42): 38721-6. doi:10.1074/jbc.M106871200 ...
Syndecan 1
"Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1". ... 3) An N-terminal chondroitin sulfate chain that also likely binds to the cationic face. Point mutagenesis of lacritin has ... The syndecan-1 core protein consists of an extracellular domain which can be substituted with heparan sulfate and chondroitin ... 2) Heparanase-cleaved heparan sulfate that is 3-O sulfated. This likely interacts with the cationic face of lacritin's C- ...
Glucuronate-2-sulfatase
... the chemical reaction of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, ... Shaklee PN, Glaser JH, Conrad HE (1985). "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans". J ... heparin and heparitin sulfate. This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester ...
Tenascin-R
... a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of ...
Danaparoid
It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate. It is chemically distinct from heparin ...
CHST7
... moieties during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by ... gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as ... Kitagawa H, Fujita M, Ito N, Sugahara K (Aug 2000). "Molecular cloning and expression of a novel chondroitin 6-O- ... This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this ...
Stem cell marker
Legg J, Jensen UB, Broad S, Leigh I, Watt FM (December 2003). "Role of melanoma chondroitin sulphate proteoglycan in patterning ... May 2006). "Lack of expression of the chondroitin sulphate proteoglycan neuron-glial antigen 2 on candidate stem cell ...
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-b-N-acetylgalactosaminyltransferase
N-acetyl-beta-D-galactosaminyl-proteoglycan This enzyme is involved in the biosynthesis of chondroitin sulfate. Rohrmann K, ... "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of ... Kitagawa H, Uyama T, Sugahara K (October 2001). "Molecular cloning and expression of a human chondroitin synthase". The Journal ... DeAngelis PL, Padgett-McCue AJ (August 2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella ...
Herbert E. Kaufman
K-sol contained chondroitin sulfate, which was a free radical scavenger to extend the usable life of the tissue in eye bank ...
Political positions of Ron Paul
Authorizes specific health claims to be made about saw palmetto, omega-3 fatty acids, glucosamine, chondroitin sulfate, and ...
Rho family of GTPases
One of the many inhibitory cues includes chondroitin sulfate proteoglycans (CSPGs). Neurons growing in culture become more able ... Jain A, Brady-Kalnay SM, Bellamkonda RV (2004). "Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan- ...
Aggrecan
It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are ... a chondroitin sulfate and a keratan sulfate region. The three globular domains, G1, G2, and G3 are involved in aggregation, ... This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the ... Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R (1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines ...
Chondroitin Sulfate: MedlinePlus Supplements
Chondroitin sulfate is a chemical found in human and animal cartilage. It is commonly used by mouth with glucosamine or other ... Chondroitin Sulfate A, Chondroitin Sulfates, Chondroitin Sulfate B, Chondroitin Sulfate C, Chondroitin Sulphates, Chondroitin ... Calcium Chondroitin Sulfate, CDS, Chondroitin, Chondroitin Polysulfate, Chondroitin Polysulphate, ... Sulfate, Condroitin, CPS, CS, CSA, CSC, GAG, Galactosaminoglucuronoglycan Sulfate, Chondroitin 4-Sulfate, Chondroitin 4- and 6- ...
Global Chondroitin Sulfate Market Size Report, 2021-2028
The global chondroitin sulfate market size was valued at USD 1.17 billion in 2020 and is expected to grow at a compound annual ... Global Chondroitin Sulfate Market Size Report, 2021-2028 GVR Report cover Chondroitin Sulfate Market Size, Share & Trends ... What is the chondroitin sulfate market growth? b. The global chondroitin sulfate market is expected to grow at a compound ... How big is the chondroitin sulfate market? b. The global chondroitin sulfate market size was estimated at USD 1.17 billion in ...
Discrepancies in composition and biological effects of different formulations of chondroitin sulfate
One such agent is chondroitin sulfate-a complex, h … ... Chondroitin sulfate has an excellent safety profile, and ... to variations in the quality of the chondroitin sulfate used for a particular study. Chondroitin sulfate is available as ... Discrepancies in composition and biological effects of different formulations of chondroitin sulfate Molecules. 2015 Mar 6;20(3 ... Moreover, some products contain a negligible amount of chondroitin sulfate and among samples with reasonable amounts, in vitro ...
Chondroitin Sulfate Archives - Vitality Science
chondroitin sulfate
Kim Alexander 0 Comments arthritis, Cancer, chondroitin sulfate, colorectal cancer, glucosamine sulfate, joint pain, ... Glucosamine and Chondroitin May Lower Risk of Colorectal Cancers June 5, 2013. July 17, 2013. ... Glucosamine and chondroitin may have cancer-fighting properties, according to a study scheduled to publish in the June 2013 ...
Wholesale Chondroitin Sulfate | Monterey Bay Herb Co
Chondroitin Sulfate #2 - Osteoarthritis | Cox Technic
Coxs Discat Plus has incorporated chondroitin sulfate since the 1960s. ... Chondroitin sulfate is used in the care of osteoarthritis due to its anti-inflammatory benefit and influence on cell matrix. ... Chondroitin sulphate: a focus on osteoarthritis. Glycoconj J. 2016 May 19. Chondroitin sulfate (CS) being a natural ... Chondroitin sulfates anti-inflammatory and potential for regeneration of damaged structures makes chondroitin sulfate one ...
Structural insights into chondroitin sulfate binding in pregnancy-associated malaria | Biochemical Society Transactions |...
Structural insights into chondroitin sulfate binding in pregnancy-associated malaria Pongsak Khunrae; Pongsak Khunrae ... A correction has been published: Structural insights into chondroitin sulfate binding in pregnancy-associated malaria ... Pongsak Khunrae, Matthew K. Higgins; Structural insights into chondroitin sulfate binding in pregnancy-associated malaria. ... chondroitin sulfate proteoglycans). This interaction is the major target for therapeutics to treat or prevent pregnancy- ...
Nutralliance Chondroitin Sulfate 90% (Porcine) BSE-TSE Statement - CH4090 | NASC LIVE
Extraction and determination of chondroitin sulfate from fish processing byproducts | Bookstore | Alaska Sea Grant
Extraction and determination of chondroitin sulfate from fish processing byproducts (book section). ... Chondroitin sulfate (CS), a sulfated glycosaminoglycan, is an important structural component of connective tissues such as ... Extraction and determination of chondroitin sulfate from fish processing byproducts. J.J. Stine, T.H. Wu, A.C.M. Oliveira, S. ... This study was conducted to determine the concentrations of chondroitin sulfate that are extractable from Alaska seafood ...
Cari Produk Chondroitin Sulfate di Apotik online
Glucosamine and chondroitin sulphate did not improve pain in osteoarthritis of the knee | BMJ Evidence-Based Medicine
NOW Foods Glucosamine and Chondroitin Sulfate Extra Strength Joint Health, 60 Tablets, 60 - Harris Teeter
Shop for NOW Foods Glucosamine and Chondroitin Sulfate Extra Strength Joint Health, 60 Tablets (60 ) at Harris Teeter. Find ... NOW Foods Glucosamine and Chondroitin Sulfate Extra Strength Joint Health, 60 Tablets. 3(. 2. )View All Reviews ... NOW Foods Glucosamine and Chondroitin Sulfate Extra Strength Joint Health, 60 Tablets ... Now Foods Glucosamine & Chondroitin are naturally occurring structural components that have recently enjoyed growing popularity ...
Chondroitin Sulfate Supplements | Benefits | Uses | Dosage | Nutrition Express by PipingRock Health Products
Indication-specific dosing for CDS, condroitin, GAG, galactosaminoglucuronoglycan (chondroitin sulfate), frequency-based...
... chondroitin sulfate), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... chondroitin sulfate (CDS%2C condroitin%2C GAG%2C galactosaminoglucuronoglycan (chondroitin sulfate))) and chondroitin sulfate ( ... Chondroitin Sulfate (Herb/Suppl). Brand and Other Names:CDS, condroitin, more...GAG, galactosaminoglucuronoglycan ... chondroitin sulfate)) What to Read Next on Medscape ... of the knee can experience some benefit from taking chondroitin ...
Over the Counter Drugs | Muscle and Joint Relief - Tagged 'chondroitin-sulfate&grid list' - Mountainside Medical...
Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis - List Labs
... in chondroitin 6-O-sulfate transferase 1-deficient (C6st1(-/-)) mice. C6ST1 is the enzyme that transfers sulfate residues to ... Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis Miyamoto, K;Tanaka, N;Moriguchi, K;Ueno, R; ... Chondroitin sulfate proteoglycans (CSPGs) are the main component of the extracellular matrix in the central nervous system (CNS ... In conclusion, the presence of sulfate at position 6 of N-acetylgalactosamine of CSPG may influence the effecter phase of EAE ...
A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and...
... hyaluronic acid and chondroitin sulfate. / Levett, Peter A.; Melchels, Ferry P. W.; Schrobback, Karsten et al. ... hyaluronic acid and chondroitin sulfate. Peter A. Levett, Ferry P. W. Melchels, Karsten Schrobback, Dietmar W. Hutmacher, Jos ... hyaluronic acid and chondroitin sulfate. In: Acta Biomaterialia. 2014 ; Vol. 10, No. 1. pp. 214-223. ... and to a lesser extent chondroitin sulfate methacrylate (CS-MA), chondrogenesis and mechanical properties can be enhanced. The ...
China good quality Chondroitin Sulfate Sodium on sales
Chinas leading Chondroitin Sulfate Sodium product market, With strict quality control Chondroitin Sulfate Sodium factories, ... Producing high quality Bovine Cartilage Chondroitin Sulfate Sodium , Natrium Element 95% Purity products. ... High quality Bovine Cartilage Chondroitin Sulfate Sodium , Natrium Element 95% Purity from China, ... Chondroitin Sulfate Sodium Chondroitin Sulfate Calcium Chondroitin Sulphate Sodium Collagen Type 1 Collagen Type 2 Shark ...
Metabolic Fate of Exogenous Chondroitin Sulfate in the Experimental Animal | Equine Clinical Research
This paper reports the results of investigations on the metabolic fate of tritiated chondroitin sulfate administered to rats ... The chondroitin sulfate (CS) used in this experimental work was a mixture of chondroitin-4-sulfate (50%) and chondroitin-6- ... such as chondroitin sulfate, dermatan sulfate and heparan sulfate, is different and more consistent absorption levels are ... CS, elution of chondroitin sulfate,G,elution of N-acetylgalactosamine.. Table 3: Distribution of radioactivity after oral ...
Glucosamine and Chondroitin Sulfate - Vital Nutrients - MTHFR Doctors
Chondroitin Sulfate helps build and support collagen, the basic substance of cartilage and joints. Both nutrients support the ... Glucosamine and Chondroitin Sulfate. Glucosamine and Chondroitin Sulfate. Glucosamine & Chondroitin Sulfate helps build and ... Glucosamine Sulfate … 750mg. (from 1000 mg of vegtable source glucosamine sul. 2KCL). Chondroitin Sulfate Sodium 80-90% … 600mg ... Be the first to review "Glucosamine and Chondroitin Sulfate" Cancel reply. Your email address will not be published. Required ...
Chondroitin sulfate perlecan enhances collagen fibril formation - Implications for perlecan chondrodysplasias :: MPG.PuRe
Chondroitin sulfate perlecan enhances collagen fibril formation - Implications for perlecan chondrodysplasias ... Chondroitin sulfate perlecan enhances collagen fibril formation - Implications for perlecan chondrodysplasias Kvist, A. J., ... 2006). Chondroitin sulfate perlecan enhances collagen fibril formation - Implications for perlecan chondrodysplasias. Journal ...
Chondroitin Sulfate-impurities | Pharmaffiliates
Chondroitin sulfate is a sulfated glycosaminoglycan composed of a chain of alternating sugars. Reference standards of ... Chondroitin Sulfate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. ... Chondroitin sulfate is used for osteoarthritis and cataracts. ... chondroitin sulfate and its Impurities Chondroitin sulfate is ... Chondroitin sulfate is a sulfated glycosaminoglycan composed of a chain of alternating sugars. Reference standards of ...
Chondroitin Sulfate - Systemic Formulas
Recommended by licensed healthcare practitioners, Systemic Formulas utilizes a proprietary blend of vitamins, minerals, enzymes, RNA/DNA tissue factors, amino acids, and botanicals which are synergistically formulated in a manner that targets a specific physiological system, while supporting the health of the body system as a whole.. ...
Chondroitin sulfate Archives - Biogetica
This peer reviewed and published research has most probably not been studied or approved by the FDA in your country as a treatment or cure. Hence no disease claims can be made and you are welcome to take the natural ingredients for (immunity, lung health, cardiovascular health, etc). Homeopathy is medicine in USA but only for OTC issues. Ayurveda is medicine only in India and TCM is medicine only in China. Switzerland supports insurance payments for Homeopathy.. De acuerdo con la Declaración de política de aplicación de la FTC sobre reclamos de comercialización de medicamentos homeopáticos de venta libre que debe mencionar cualquier persona que venda homeopatía.. No hay suficiente evidencia científica de que la homeopatía funciona, y. The products claims are based only on theories of homeopathy from the 1700s that are not accepted by most modern medical experts. ...
Atoma Glucosamine & Chondroitin Sulfate Caplets
Provides 500 mg of glucosamine sulfate and 400 mg of chondroitin sulfate in every caplet Relieves osteoarthr ... Glucosamine Chondroitin Double Strength from Atoma helps relieve joint pain associated with osteoarthritic conditions. This ... Strength: Glucosamine Sulfate 500mg & Chondroitin Sulfate 400mg Glucosamine Sulfate 500mg & Chondroitin Sulfate 400mg ... Provides 500 mg of glucosamine sulfate and 400 mg of chondroitin sulfate in every caplet. Relieves osteoarthritic joint pain. ...
Extracted Chondroitin Sulfate Bovine Sodium
Bulk Supplements, Chondroitin Sulfate - 3.5 oz
Chondroitin sulfate is composed of a chain of sugars and is a major component of tendons, ligaments, and bones. It can be ... What Is Chondroitin Sulfate?. Chondroitin sulfate is composed of a chain of sugars and is a major component of tendons, ... Chondroitin Sulfate Benefits. Chondroitin sulfate helps support joint health and may help support the heart, bladder, and eyes ... Youre reviewing:Bulk Supplements, Chondroitin Sulfate - 3.5 oz. Your Rating. Rate this product. 1 star 2 stars 3 stars 4 stars ...
Adrien Gagnon Glucosamine Sulfate and Chondroitin
This product provides full doses of glucosamine sulfate and chondroitin sulfate for an optimal efficacy in case of ... Glucosamine sulfate (glucosamine sulfate 2KCl) from outer shells (chitin) of shellfish , Chondroitin sulfate (calf trachea), ... Note: The production of glucosamine sulfate and chondroitin sulfate by the body decreases with age. Using these substances as ... This product provides full doses of glucosamine sulfate and chondroitin sulfate for an optimal efficacy in case of ...
ProteoglycansHyaluronicGlycosaminoglycanOsteoarthritisProteoglycanSupplementHeparinHyaluronateGlucosamine Sulphate1200 mgIngredientsContains chondroitinSuggests that chondroitinGreen lippedTracheaJointsWorks synergistically to provide1000TabletsProductsVitroPorcineNutrientsPowderBovineDegenerationTogether with glucosamineCalcium iodateStructuralSulfate'sCrustaceansSynergisticallyKneeMolecular weightProteinNaturallyJoint cartilageSubstanceMussel2020
Proteoglycans5
- Malaria during pregnancy is caused when parasite-infected erythrocytes accumulate within the placenta through interactions between the VAR2CSA protein on the infected erythrocyte surface and placental CSPGs (chondroitin sulfate proteoglycans). (portlandpress.com)
- Chondroitin sulfate proteoglycans (CSPGs) are the main component of the extracellular matrix in the central nervous system (CNS) and influence neuroplasticity. (listlabs.com)
- To solve these problems, we have systematically generated collagen (Coll) scaffolds with interpenetrating polymer networks (IPN) of hyaluronic acid (HA) or chondroitin sulfate proteoglycans (CS) or both. (ox.ac.uk)
- Chondroitin sulfate is one of the main components of the cartilage, where it merges with a central protein, forming proteoglycans, which attribute mechanical and elastic properties to cartilages. (bionat.gr)
- Cartilage is made of water (70%) and a type II collagen framework with proteoglycans and glycosaminoglycans (consisting mainly of aggrecan and also chondroitin), produced by chondrocytes. (bmj.com)
Hyaluronic9
- We encapsulated human chondrocytes in Gel-MA-based hydrogels, and show that with the incorporation of small quantities of photocrosslinkable hyaluronic acid methacrylate (HA-MA), and to a lesser extent chondroitin sulfate methacrylate (CS-MA), chondrogenesis and mechanical properties can be enhanced. (hw.ac.uk)
- Interpenetrating polymer networks of collagen, hyaluronic acid, and chondroitin sulfate as scaffolds for brain tissue engineering. (ox.ac.uk)
- In this study, we developed interpenetrating polymer network scaffolds comprising Coll, and incorporating two commonly found GAGs in the brain, chondroitin sulfate (CS) and/or hyaluronic acid (HA). (ox.ac.uk)
- 45,208 Another theory holds that chondroitin increases the amount of hyaluronic acid in the joints. (foundhealth.com)
- Get maximum joint support with 21st Century Glucosamine & Chondroitin Plus Hyaluronic Acid + MSM - Maximum Strength. (swansonvitamins.com)
- In addition to time-tested joint nutrients glucosamine and chondroitin, this formula includes MSM (methylsulfonylmethane) and hyaluronic acid. (swansonvitamins.com)
- 21st Century's Glucosamine & Chondroitin Plus Hyaluronic Acid + MSM combines all four nutritional elements for optimal joint support. (swansonvitamins.com)
- Other related anionic glycosaminoglycans such as the chondroitin sulphates A, B, and C and hyaluronic acid have no effect on rosette formation. (ox.ac.uk)
- A 2014 study conducted on Labrador retrievers found that administering hydrolyzed collagen along with hyaluronic acid, glucosamine, chondroitin sulfate, and gamma oryzanol help to alleviate the symptoms and lessen the occurrence of elbow dysplasia, a common deformity of the elbow joint. (amandean.com)
Glycosaminoglycan4
- Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and extracellular matrix. (coxtechnic.com)
- Chondroitin sulfate (CS), a sulfated glycosaminoglycan, is an important structural component of connective tissues such as cartilage and the extracellular matrix. (uaf.edu)
- Chondroitin sulfate is a sulfated glycosaminoglycan composed of a chain of alternating sugars. (pharmaffiliates.com)
- A combination of protein and carbohydrate analytical techniques indicates that the interchain linkage is mediated bya chondroitin 4-sulfate glycosaminoglycan that originates from a typical 0-glycosidic link to Ser-10 of the right chain. (moam.info)
Osteoarthritis14
- Chondroitin sulfate is used for osteoarthritis and cataracts. (medlineplus.gov)
- Taking chondroitin sulfate by mouth seems to provide some relief from osteoarthritis pain and improve function. (medlineplus.gov)
- Sodium chondroitin sulfate is widely used in the nutraceutical industry as a dietary supplement for the treatment of osteoarthritis and joint pain. (grandviewresearch.com)
- It is therefore vitally important that only pharmaceutical-grade chondroitin sulfate be used for treating osteoarthritis patients. (nih.gov)
- Now, chondroitin sulfate for use in osteoarthritis treatment is the focus of this report. (coxtechnic.com)
- This review highlights the potential of chondroitin sulfate, either alone or in combination with other drugs, to attract the scientists engaged in osteoarthritis treatment and management across the world. (coxtechnic.com)
- EP Grade porcine Chondroitin sulfate sodium is usually used for osteoarthritis. (chondroitinpowder.com)
- This product provides full doses of glucosamine sulfate and chondroitin sulfate for an optimal efficacy in case of osteoarthritis or cartilage wear and tear. (pharmaholic.com)
- Tried or prescribed Chondroitin Sulfate for Osteoarthritis? (foundhealth.com)
- Based on the evidence of preliminary double-blind studies, chondroitin is widely used as a treatment for osteoarthritis, the typical arthritis that many people suffer as they get older. (foundhealth.com)
- According to some but not all double-blind, placebo-controlled studies chondroitin may relieve symptoms of osteoarthritis. (foundhealth.com)
- A double-blind randomized clinical trial - a top line research study - revealed that combined chondroitin sulfate and glucosamine does nearly the same as celecoxib for symptoms, function, and joint swelling in persons with symptomatic knee osteoarthritis at 6 months. (spengelchiropractic.com)
- Patients with conditions like osteoarthritis - a result of wear and tear on cartilage and joints which many of us San Jose back pain sufferers experience as we age - may benefit from chondroitin sulfate. (mcmurraychiropracticsolutions.com)
- In scientific studies in patients with wear and tear arthritis (osteoarthritis), that 1, 5 g GlucosaminHCl 0, 8 g of chondroitin sulfate a day can stop the progression of joint wear and can significantly reduce the pain associated turns out. (tat2009.com)
Proteoglycan2
- The nutritional approach continues to hold hope for back pain sufferers as the disc matrix components are known, two key ones being chondroitin sulfate proteoglycan and hyaluronan. (flbackpaincenter.com)
- The Association between Genes Polymorphisms of Heparan Sulfate Proteoglycan 2 (HSPG2) and Chondroitin Sulfate Proteoglycan 2 (CSPG2) and Intracranial Aneurysm Susceptibility: A Meta-Analysis. (cdc.gov)
Supplement9
- Summit Nutritionals International, a world leader of raw Chondroitin Sulfate, is proud to offer Droi-Kon® a specialized, 100% water soluble chondroitin powder supplement that has been shown through scientific studies to play an integral role in the formation and maintenance of joint cartilage. (droi-kon.com)
- As described in the previous section, the supplement chondroitin is often combined with glucosamine . (foundhealth.com)
- Whether you're looking to support your joints through intense exercise, Chondroitin, or simply want to relieve occasional joint discomfort, our Glucosamine, Turmeric & MSM supplement can help keep you active and complement a healthy lifestyle. (pohsili.com)
- ADEMA #ad - To keep the joints healthy, please supplement the Glucosamine and Chondroitin Sulfate timely. (pohsili.com)
- Glucosamine and chondroitin sulfate is recommended by doctors to nourish the human joints and supplement the joints needed to keep healthy. (pohsili.com)
- It has no excess smell and is a Glucosamine and Chondroitin Sulfate supplement that supports long-term use. (pohsili.com)
- Consider adding a disc supplement that has chondroitin sulfate to your routine after we talk. (flbackpaincenter.com)
- In addition to powerhouse ingredients like Glucosamine and Chondroitin Healthy Promise supplements also proudly carry the National Animal Supplement Council (NASC) Seal, which is earned for complying with stringent quality control standards and much more. (littledognation.com)
- If taken by itself Chondroitin has the same dosage as Glucosamine and a loading dose is also required when first starting the supplement as it builds up in the system tapering, like Glucosamine, to a smaller dose to maintain therapeutic levels. (dogquality.com)
Heparin1
- In this paper we show that a group of sulphated glycoconjugates including sulphatide, dextran sulphate, and fucoidan are more effective rosette reversing agents than heparin and are active against both laboratory strains and wild isolates. (ox.ac.uk)
Hyaluronate1
- An injectable solution containing chondroitin sulfate and sodium hyaluronate is approved by the FDA to protect the eye during cataract surgery. (medlineplus.gov)
Glucosamine Sulphate1
- Glucosamine Sulphate which assists the creation of new cartilage. (canagan.com)
1200 mg2
- Chondroitin sulfate is most commonly used by adults in doses of 800-1200 mg per day, for up to 2 years. (medlineplus.gov)
- Two tablets per day delivers glucosamine HCI 1500 mg & Chondroitin Sulfate 1200 mg. (pohsili.com)
Ingredients5
- Chondroitin sulfate is possibly safe when used together with other ingredients in an eye drop. (medlineplus.gov)
- It is often used in combination with other ingredients, including manganese ascorbate, glucosamine sulfate, glucosamine hydrochloride, or N-acetyl glucosamine. (chondroitinpowder.com)
- Joint health, mobility, and comfort*: NOW Extra Strength Glucosamine & Chondroitin combines two well-known joint support ingredients in their sulfate forms. (pohsili.com)
- Glucosamine, chondroitin, soy-free, dairy-free, shellfish-free, Turmeric & MSM is made in the USA from global ingredients in a GMP-certified facility. (pohsili.com)
- Active Ingredients per Soft Chew: Glucosamine (600 mg), MSM (400 mg), Chondroitin Sulfate (250 mg), Flex Boost Naturals Blend (45 mg), BioPerine (2.5 mg). (littledognation.com)
Contains chondroitin1
- It also contains chondroitin sulfate and glucosamine, Best Buy On Finasteride compounds sold as pricey supplements to reduce swelling and joint. (hotelgoldensuitesandspa.gr)
Suggests that chondroitin2
- Early research suggests that chondroitin might cause the spread or recurrence of prostate cancer. (medlineplus.gov)
- This suggests that chondroitin was able to stop the arthritis from gradually getting worse. (foundhealth.com)
Green lipped1
- (3,4,5) Cox created a spinal nutritional formula called Discat Plus that incorporates chondroitin sulfate from a green lipped mussel called perna canaliculus to enhance any potential disc regeneration. (spengelchiropractic.com)
Trachea1
- Chondroitin sulfate is a compound that occurs naturally in the human body as a component of hyaline cartilage matrix, which, together with type II collagen, makes up the translucent, glass-like cartilage found in synovial joints, the tips of the ribs, and the respiratory tract, including the nose, trachea and bronchi. (herbco.com)
Joints7
- Glucosamine & Chondroitin Sulfate helps build and support collagen, the basic substance of cartilage and joints. (mthfrdoctors.com)
- Chondroitin is also believed to block enzymes that break down cartilage in the joints. (foundhealth.com)
- An important feature of the study of 42 individuals mentioned previously was that the individuals taking a placebo showed progressive joint damage over the year, but among those taking chondroitin sulfate no worsening of the joints was seen. (foundhealth.com)
- Chondroitin is anti-inflammatory-it helps reduce swelling around joints-and prevents the degradation of joint cartilage. (onestoppeshoppe.com)
- Also, Glucosamine and chondroitin sulfate have been added for supporting healthy joints. (isefmd.org)
- Chondroitin Sulphate which reduces enzymes which damage cartilage in joints. (canagan.com)
- Glucosamine, both the sulfate and the HCl work by reducing inflammation in the joints and they have anti-inflammatory properties, as well as cartilage protecting effects. (dogquality.com)
Works synergistically to provide2
- Now Foods Chondroitin complements Glucosamine and works synergistically to provide optimal nutritional support. (harristeeter.com)
- Chondroitin enhances Glucosamine and works synergistically to provide gold standard nutritional aid. (ycszkj.top)
10001
- Amino acid complex based on hydrolyzed collagen (bovine skin) 3000 mg + glucosamine sulfate (crustaceans: crabs, shrimps) 1000 mg + chondroitin sulfate (bovine tracheae) 500 mg + methylsulfonylmethane (MSM) 1500 mg. (flobax.com)
Tablets3
- The wrist, and waist pain caused by increasing age can be used to relieve the uncomfortable symptoms by Glucosamine and Chondroitin Sulfate supplementation, knee, if you develop the above symptoms, you can try to take Extra Strength Glucosamine 1500mg / Chondroitin 1200mg Sulfate-220 Tablets. (pohsili.com)
- If you already have joint pain in your knee or elsewhere, you should immediately use the Extra Strength Glucosamine 1500mg / Chondroitin 1200mg Sulfate-220 Tablets, to expect better use and joint health. (pohsili.com)
- ArtVitum is a of the few products that reach the necessary optimal daily dose of GlucosaminHCl and chondroitin sulfate recommended taking 2 tablets from morning and evening. (tat2009.com)
Products8
- There is concern that some chondroitin sulfate products are not labeled accurately. (medlineplus.gov)
- Some products might contain no chondroitin, while other products might contain more than the amount stated on the product's label. (medlineplus.gov)
- Because of these issues, the effects of different chondroitin products may vary. (medlineplus.gov)
- Sodium chondroitin sulfate is also used in dietary supplements and food products as thickeners, additives, forming agents, preservatives, in health food, and in animal feed. (grandviewresearch.com)
- Chondroitin sulfate is available as pharmaceutical- and nutraceutical-grade products, and the latter have great variations in preparation, composition, purity and effects. (nih.gov)
- Moreover, some products contain a negligible amount of chondroitin sulfate and among samples with reasonable amounts, in vitro testing showed widely varying effects. (nih.gov)
- 187 It has been suggested that chondroitin, like glucosamine, may primarily show benefit in studies funded by manufacturers of chondroitin products. (foundhealth.com)
- there are products, the GlucosaminHCl and contain chondroitin? (tat2009.com)
Vitro1
- The aim of this study was to present chondroitin sulfate as a plant growth regulator and to give an overview about light effects on PLBs (protocorm like bodies) culture of Cymbidium dayanum and Cymbidium finlaysonianum cultured in vitro . (notulaebiologicae.ro)
Porcine2
- EP Grade Porcine Chondroitin sulfate sodium 95% is extracted from porcine cartilages with purity of 95% that complies with EP 7.0 standard. (chondroitinpowder.com)
- Porcine chondroitin sulfate sodium is powder of white to yellowish clolor, and is extremely hygroscopic once dried. (chondroitinpowder.com)
Nutrients1
- Chondroitin sulfate and glucosamine sulfate are particularly important nutrients to the disc. (mcmurraychiropracticsolutions.com)
Powder1
- 2014 March--- MSC Verified for Shark Chondroitin and Shark Cartilage Powder. (chondroitinpowder.com)
Bovine1
- Bovine-derived sodium chondroitin sulfate is used in various applications including nutraceuticals, pharmaceuticals, and animal feed. (grandviewresearch.com)
Degeneration4
- The following facts, and I have many more studies even more detailed on the benefits of chondroitin sulfate on disc degeneration retardation and regeneration, will direct clinical use of Discat Plus with patients who have disc degeneration, discogenic back pain, joint arthritis, and chemical origin spine pain. (coxtechnic.com)
- Now, today, research grows in volume and recognition of chondroitin sulfate's role in disc degeneration . (spengelchiropractic.com)
- Chiropractic author Cox often cites literature on not only reversing disc degeneration but actually enhancing regeneration of degenerated discs with chondroitin sulfate and distraction manipulation . (spengelchiropractic.com)
- Listen to this PODCAST with Dr. James Cox on The Back Doctors Podcast with Dr. Michael Johnson as he presents research on the role of chondroitin sulfate in the health, degeneration and potential regeneration of the intervertebral disc and in the Cox® Technic System of Spinal Pain Management . (flbackpaincenter.com)
Together with glucosamine1
- Taking chondroitin sulfate together with glucosamine hydrochloride might reduce blood levels of glucosamine. (medlineplus.gov)
Calcium iodate1
- Zinc (as amino acid zinc chelate hydrate) 25 mg, copper (as copper (II) sulfate pentahydrate) 10 mg, manganese 10 mg, iodine (as calcium iodate, anhydrous) 2.0 mg, selenium (as sodium selenite) 0.2 mg, zinc (as zinc oxide) 70 mg, iron 130 mg. (bosch-tiernahrung.de)
Structural1
- Now Foods Glucosamine & Chondroitin are naturally occurring structural components that have recently enjoyed growing popularity. (harristeeter.com)
Sulfate's1
- Chondroitin sulfate's anti-inflammatory and potential for regeneration of damaged structures makes chondroitin sulfate one vital nutrient to be shared with back pain and spine pain patients. (coxtechnic.com)
Crustaceans1
- chondroitin sulfate - 624 mg. from the chitinous shell of shrimp and other crustaceans (Crustacean), glucosamine sulfate - 780 mg of shark cartilage. (vivasan.bg)
Synergistically1
- Includes vitamin C, manganese, and bromelain, which work synergistically to enhance the proven benefits of glucosamine and chondroitin. (liveloveorganiclife.com)
Knee1
- Good results were seen in a 12-month, double-blind trial that compared chondroitin against placebo in 104 individuals with arthritis of the knee,35 as well as in a 12-month trial of 42 participants. (foundhealth.com)
Molecular weight1
- The chondroitin sulfate (CS) used in this experimental work was a mixture of chondroitin-4-sulfate (50%) and chondroitin-6-sulfate (50%) with an average molecular weight of 14,000 daltons, an SO 3 H/COOH ratio near to 1, devoid of anticoagulant activity. (vitaflex.com)
Protein3
- Glucosamine and Chondroitin Sulfate are necessary for building the protein molecules responsible for giving cartilage its strength and resilience. (mthfrdoctors.com)
- It is composed of collagenous fibers embedded in chondroitin sulfate (a protein-carbohydrate). (scienceoutlined.com)
- Was examined in a new American research, whether also known as Chondroprotektiva" designated joint modules GlucosaminHCl and chondroitin sulfate of support protein production can increase collagen in cartilage cells. (tat2009.com)
Naturally2
- Chondroitin sulfate is a naturally occurring substance in the body. (foundhealth.com)
- Both glucosamine and chondroitin occur naturally in our bodies. (healthcaringz.com)
Joint cartilage1
- Chondroitin is responsible for keeping the joint cartilage lubricated by absorbing water and providing the building blocks for new cartilage. (onestoppeshoppe.com)
Substance2
- Chondroitin Sulfate is a proven natural substance for joint health and is used around the world for canine joint support. (droi-kon.com)
- Chondroitin sulfate is one of the most vital of the compounds in connective tissue which are responsible for building and supporting the ground substance of cartilage. (holistichealthonline.info)
Mussel1
- All of Lotus' wholesome, balanced nutrition plus extras for the joint health of your senior dog like New Zealand green mussel, glucosomine, and Chondroitin help him act like a puppy again (minus the whole potty-training thing). (zendogri.com)
20201
- The global chondroitin sulfate market size was valued at USD 1.17 billion in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 3.0% from 2020 to 2028. (grandviewresearch.com)