Chondroitin Lyases: Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Bacteroides: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Chondroitin: A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Lyases: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.Chondroitin ABC Lyase: An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Proteoglycans: Glycoproteins which have a very high polysaccharide content.Disaccharides: Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.Bacteroides fragilis: Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.Bacteroides Infections: Infections with bacteria of the genus BACTEROIDES.Proteus vulgaris: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Flavobacteriaceae Infections: Infections with bacteria of the family FLAVOBACTERIACEAE.Flavobacteriaceae: A family of bacteria in the order Sphingobacteriales, class Sphingobacteria. They are gram-negative rods, mostly saprophytic in terrestrial and aquatic habitats.Tenacibaculum: A genus of gram-negative, rod-shaped bacteria in the family FLAVOBACTERIACEAE. Tenacibaculum adheres to surfaces of marine organisms and is pathogenic to fish.Fish Diseases: Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Lipoproteins, LDL: A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Foam Cells: Lipid-laden macrophages originating from monocytes or from smooth muscle cells.Receptors, Transforming Growth Factor beta: Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Activin Receptors, Type I: One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB).Mesylates: Organic salts or esters of methanesulfonic acid.Molecular Weight: The sum of the weight of all the atoms in a molecule.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Keratan Sulfate: A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.Acetylglucosaminidase: A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase: A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Glycoside HydrolasesCarbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Decorin: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Cyclin-Dependent Kinase Inhibitor p27: A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.Myocytes, Smooth Muscle: Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cyclin-Dependent Kinase Inhibitor p21: A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.International Agencies: International organizations which provide health-related or other cooperative services.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.

Action of chondroitinases. II. Numerical calculation of the degree of multiple attack. (1/149)

Further investigation was carried out on the action patterns of two chondroitinase-AC [EC 4.2.2.5.] preparations obtained from Arthrobacter aurescens and Flavobacterium heparinum. To infer the action patterns of the chondroitinases, we proposed a new method for the calculation of the degree of multiple attack, based on the concept established by Robyt and French ((1967) Arch. Biochem. Biophys. 122, 8-16). It was shown that the degree of multiple attack (DM) is represented by the ratio of the initial velocity of number-average degree of scission to that of viscosity-average degree of scission. By this method, DM for A-Chase was estimated to be 3.03 and for F-chase, 1.31.  (+info)

Substrate specificity studies of Flavobacterium chondroitinase C and heparitinases towards the glycosaminoglycan--protein linkage region. Use of a sensitive analytical method developed by chromophore-labeling of linkage glycoserines using dimethylaminoazobenzenesulfonyl chloride. (2/149)

Bacterial chondroitinases and heparitinases are potentially useful tools for structural studies of chondroitin sulfate and heparin/heparan sulfate. Substrate specificities of Flavobacterium chondroitinase C, as well as heparitinases I and II, towards the glycosaminoglycan-protein linkage region -HexA-HexNAc-GlcA-Gal-Gal-Xyl-Ser (where HexA represents glucuronic acid or iduronic acid and HexNAc represents N-acetylgalactosamine or N-acetylglucosamine) were investigated using various structurally defined oligosaccharides or oligosaccharide-serines derived from the linkage region. In the case of oligosaccharide-serines, they were labeled with a chromophore dimethylaminoazobenzenesulfonyl chloride (DABS-Cl), which stably reacted with the amino group of the serine residue and rendered high absorbance for microanalysis. Chondroitinase C cleaved the GalNAc bond of the pentasaccharides or hexasaccharides derived from the linkage region of chondroitin sulfate chains and tolerated sulfation of the C-4 or C-6 of the GalNAc residue and C-6 of the Gal residues, as well as 2-O-phosphorylation of the Xyl residue. In contrast, it did not act on the GalNAc-GlcA linkage when attached to a 4-O-sulfated Gal residue. Heparitinase I cleaved the innermost glucosaminidic bond of the linkage region oligosaccharide-serines of heparin/heparan sulfate irrespective of substitution by uronic acid, whereas heparitinase II acted only on the glucosaminidic linkages of the repeating disaccharide region, but not on the innermost glucosaminidic linkage. These defined specificities of chondroitinase C, as well as heparitinases I and II, will be useful for preparation and structural analysis of the linkage oligosaccharides.  (+info)

Sulfate incorporation from ascorbate 2-sulfate into chondroitin sulfate by embryonic chick cartilage epiphyses. (3/149)

Radioactivity was significantly incorporated from ascorbate 2-[35S]sulfate into chondroitin sulfate by embryonic chick cartilage epiphyses. The extent of incorporation was comparable with that from inorganic [35S]sulfate. The radioactive chondroitin sulfate formed from ascorbate 2-[35S]sulfate gave two radioactive disaccharides on chondroitinase-ABC [EC 4.2.2.4] digestion. The incorporation was markedly decreased by inorganic sulfate. The time course of incorporation from ascorbate 2-[35S]sulfate and inorganic [35S]sulfate into chondroitin sulfate and the constituent disaccharides suggest that the incorporation rates from the two radioactive substances are different.  (+info)

Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate. (4/149)

We report here the isolation and sulphation isomer analyses of trisaccharides GalNAcS(beta1,4)GlcA(beta1,3)GalNAcS (in which S indicates sulphate) derived from the non-reducing termini of aggrecan chondroitin sulphate. Rat chondrosarcoma and human aggrecans were digested for 1 h at 37 degrees C with 30 micro-units of endo-chondroitinase ABC per microgram of chondroitin sulphate, and trisaccharides were isolated from the digests by ToyoPearl HW40S gel-filtration chromatography. Four trisaccharide species were identified; their sulphation isomer compositions, as determined by digestion with chondroitinase ACII and fluorescence-based ion-exchange HPLC, were GalNAc4Sbeta1,4GlcAbeta1,3GalNAc4S, GalNAc4Sbeta1,4GlcAbeta1,3GalNAc6S, GalNAc4,6Sbeta1,4GlcAbeta1, 3GalNAc4S and GalNAc4,6Sbeta1,4GlcAbeta1,3GalNAc6S. The abundances of such sequences in chondroitin sulphate on aggrecan from normal (foetal to 72 years of age) and from osteoarthritic human knee cartilages were also established. The results showed that non-reducing terminal GalNAc4S or GalNAc4,6S can be linked to either a 4-sulphated or a 6-sulphated disaccharide, suggesting that the sulphation of the last disaccharide might not have a direct effect on the specificity of chondroitin sulphate terminal GalNAc sulphotransferases. Furthermore, for each aggrecan preparation examined, the 4S-to-6S ratio of all chain interior disaccharides was equivalent to that in the last repeating disaccharides at the non-reducing terminus, suggesting that neither chondroitin 4-sulphotransferase nor chondroitin 6-sulphotransferase shows preferential activity near the chain terminus.  (+info)

Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes chondroitinase AC and chondroitinase B, respectively, from Flavobacterium heparinum. (5/149)

In medium supplemented with chondroitin sulfate, Flavobacterium heparinum synthesizes and exports two chondroitinases, chondroitinase AC (chondroitin AC lyase; EC 4.2.2.5) and chondroitinase B (chondroitin B lyase; no EC number), into its periplasmic space. Chondroitinase AC preferentially depolymerizes chondroitin sulfates A and C, whereas chondroitinase B degrades only dermatan sulfate (chondroitin sulfate B). The genes coding for both enzymes were isolated from F. heparinum and designated cslA (chondroitinase AC) and cslB (chondroitinase B). They were found to be separated by 5.5 kb on the chromosome of F. heparinum, transcribed in the same orientation, but not linked to any of the heparinase genes. In addition, the synthesis of both enzymes appeared to be coregulated. The cslA and cslB DNA sequences revealed open reading frames of 2,103 and 1,521 bp coding for peptides of 700 and 506 amino acid residues, respectively. Chondroitinase AC has a signal sequence of 22 residues, while chondroitinase B is composed of 25 residues. The mature forms of chondroitinases AC and B are comprised of 678 and 481 amino acid residues and have calculated molecular masses of 77,169 and 53,563 Da, respectively. Truncated cslA and cslB genes have been used to produce active, mature chondroitinases in the cytoplasm of Escherichia coli. Partially purified recombinant chondroitinases AC and B exhibit specific activities similar to those of chondroitinases AC and B from F. heparinum.  (+info)

A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides. (6/149)

A previously published method for the analysis of glycosaminoglycan disaccharides by high pH anion exchange chromatography (Midura,R.J., Salustri,A., Calabro,A., Yanagishita,M. and Hascall,V.C. (1994), Glycobiology,4, 333-342) has been modified and calibrated for chondroitin and dermatan sulfate oligosaccharides up to hexasaccharide in size and hyaluronan oligosaccharides up to hexadecasaccharide. For hyaluronan oligosaccharides chain length controls elution position; however, for chondroitin and dermatan sulfate oligosaccharides elution times primarily depend upon the level of sulfation, although chain length and hence charge density plays a role. The sulfation position of GalNAc residues within an oligosaccharide is also important in determining its elution position. Compared to 4-sulfation a reducing terminal 6-sulfate retards elution; however, when present on an internal GalNAc residue it is the 4-sulfate containing oligosaccharide which elutes later. These effects allow discrimination between oligosaccharides differing only in the position of GalNAc sulfation. Using this simple methodology, a Dionex CarboPac PA-1 column with NaOH/NaCl eluents and detection by absorbance at 232 nm, a quantitative analytical fingerprint of a chondroitin/dermatan sulfate chain may be obtained, allowing a determination of the abundance of chondroitin sulfate, dermatan sulfate, and hyaluronan along with an analysis of structural features with a linear response to approximately 0.1 nmol. The method may readily be calibrated using either commercial disaccharides or the di- and tetrasaccharide products of a limit digest of commercial chondroitin sulfate by chondroitin ABC endolyase. Commercially available and freshly prepared shark, whale, bovine, and human cartilage chondroitin sulfates have been examined by this methodology and we have confirmed that freshly isolated shark cartilage CS contains significant amounts of the biologically important GlcA2Sbeta(1-3)GalNAc6S structure.  (+info)

Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection. (7/149)

Respiratory syncytial virus (RSV) is an important human respiratory pathogen, particularly in infants. Glycosaminoglycans (GAGs) have been implicated in the initiation of RSV infection of cultured cells, but it is not clear what type of GAGs and GAG components are involved, whether the important GAGs are on the virus or the cell, or what the magnitude is of their contribution to infection. We constructed and rescued a recombinant green fluorescent protein (GFP)-expressing RSV (rgRSV) and used this virus to develop a sensitive system to assess and quantify infection by flow cytometry. Evaluation of a panel of mutant Chinese hamster ovary cell lines that are genetically deficient in various aspects of GAG synthesis showed that infection was reduced up to 80% depending on the type of GAG deficiency. Enzymatic removal of heparan sulfate and/or chondroitin sulfate from the surface of HEp-2 cells also reduced infection, and the removal of both reduced infection even further. Blocking experiments in which RSV was preincubated with various soluble GAGs revealed the relative blocking order of: heparin > heparan sulfate > chondroitin sulfate B. Iduronic acid is a component common to these GAGs. GAGs that do not contain iduronic acid, namely, chondroitin sulfate A and C and hyaluronic acid, did not inhibit infection. A role for iduronic acid-containing GAGs in RSV infection was confirmed by the ability of basic fibroblast growth factor to block infection, because basic fibroblast growth factor binds to GAGs containing iduronic acid. Pretreatment of cells with protamine sulfate, which binds and blocks GAGs, also reduced infection. In these examples, infection was reduced by pretreatment of the virus with soluble GAGs, pretreatment of the cells with GAG-binding molecules, pretreatment of the cells with GAG-destroying enzymes or in cells genetically deficient in GAGs. These results establish that the GAGs involved in RSV infection are present on the cell rather than on the virus particle. Thus, the presence of cell surface GAGs containing iduronic acid, like heparan sulfate and chondroitin sulfate B, is required for efficient RSV infection in cell culture.  (+info)

Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates. (8/149)

Sulfated glycosaminoglycans were isolated from 23 species of 13 phyla of invertebrates and characterized by their electrophoretic migration in three different buffer systems coupled with enzymatic degradation using bacterial heparinase, heparitinases and chondroitinase AC. Heparan sulfate is a ubiquitous compound present in all species analyzed whereas chondroitin sulfate was present in 20 species and heparin-like compounds in 12 species of the invertebrates. The heparin-like compounds were purified from the echinoderm Mellita quinquisperforata (sand dollar) and the crustacean Ucides cordatus (crab) with anticoagulant activities of 60 and 52 IU/mg, respectively. Degradation of these heparins with heparinase produced significant amounts of the trisulfated disaccharide typical of mammalian heparins. This was confirmed by 13C-NMR spectroscopy of the crab heparin. An updated phylogenetic tree of the distribution of sulfated glycosaminoglycans in the animal kingdom is also presented.  (+info)

*Chondroitin ABC lyase

... (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic ... Chondroitin ABC lyase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... name chondroitin ABC lyase. This enzyme catalyses the following chemical reaction Eliminative degradation of polysaccharides ... chondroitin 6-sulfate and dermatan sulfate. Following a spinal cord injury, this enzyme can be used to erode scar tissue that ...

*Chondroitin B lyase

In enzymology, a chondroitin B lyase (EC 4.2.2.19) is an enzyme that catalyzes the chemical reaction Eliminative cleavage of ... The systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ... Gu K, Linhardt RJ, Laliberte M, Gu K, Zimmermann J. "Purification, characterization and specificity of chondroitin lyases and ... V, Sasisekharan R, Cygler M (2004). "The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides ...

*Chondroitin AC lyase

... chondroitin sulfate lyase, chondroitin AC eliminase, chondroitin AC lyase, chondroitinase AC, and ChnAC. As of late 2007, 11 ... In enzymology, a chondroitin AC lyase (EC 4.2.2.5) is an enzyme that catalyzes the chemical reaction Eliminative degradation of ... The systematic name of this enzyme class is chondroitin AC lyase. Other names in common use include chondroitinase (ambiguous ... "Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced ...

*Chondroitin sulfate ABC lyase

... may refer to: Chondroitin ABC lyase, an enzyme Chondroitin-sulfate-ABC exolyase, an enzyme ...

*Chondroitin-sulfate-ABC exolyase

... chondroitin ABC lyase (ambiguous), chondroitin sulfate ABC lyase (ambiguous), ChS ABC lyase (ambiguous), chondroitin sulfate ... specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is chondroitin- ... "Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially ... ABC exoeliminase, chondroitin sulfate ABC exolyase, and ChS ABC lyase II. Yamagata T, Saito H, Habuchi O, Suzuki S (1968). " ...

*List of MeSH codes (D08)

... chondroitin lyases MeSH D08.811.520.241.700.350.500.500 --- chondroitin abc lyase MeSH D08.811.520.241.700.512 --- heparin ... polysaccharide-lyases MeSH D08.811.520.241.700.350 --- chondroitinases and chondroitin lyases MeSH D08.811.520.241.700.350.500 ... tyrosine phenol-lyase MeSH D08.811.520.232.300 --- amidine-lyases MeSH D08.811.520.232.300.200 --- adenylosuccinate lyase MeSH ... chondroitinases and chondroitin lyases MeSH D08.811.277.352.827.180.175 --- chondroitinsulfatases MeSH D08.811.277.352.827.180. ...

*Chondroitinase

... an enzyme Chondroitin ABC lyase, an enzyme. ...

*CHNB

Ontario Chondroitin B lyase, an enzyme. ...

*List of EC numbers (EC 4)

... pectate lyase EC 4.2.2.3: poly(b-D-mannuronate) lyase EC 4.2.2.4: chondroitin ABC lyase EC 4.2.2.5: chondroitin AC lyase EC 4.2 ... chondroitin B lyase EC 4.2.2.20: chondroitin-sulfate-ABC endolyase EC 4.2.2.21: chondroitin-sulfate-ABC exolyase EC 4.2.2.22: ... pectin lyase EC 4.2.2.11: poly(a-L-guluronate) lyase EC 4.2.2.12: xanthan lyase EC 4.2.2.13: exo-(1-4)-α-D-glucan lyase EC 4.2. ... oligogalacturonide lyase EC 4.2.2.7: heparin lyase EC 4.2.2.8: heparin-sulfate lyase EC 4.2.2.9: pectate disaccharide-lyase EC ...

*Heparin

The lyases have mainly been used in heparin/HS studies. The bacterium produces three lyases, heparinases I (EC 4.2.2.7), II (no ... The most prevalent impurity in heparin is dermatan sulfate (DS), also known as chondroitin sulfate B. The building-block of DS ... The lyases cleave heparin/HS by a beta elimination mechanism. This action generates an unsaturated double bond between C4 and ... Danaparoid, a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate can be used as an anticoagulant in patients ...

*List of EC numbers (EC 3)

The activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase EC 3.13.1.3: 2'-hydroxybiphenyl-2- ... unsaturated chondroitin disaccharide hydrolase EC 3.2.1.181: galactan endo-beta-1,3-galactanase EC 3.2.1.182: 4-hydroxy-7- ... citrate lyase deacetylase EC 3.1.2.17: (S)-methylmalonyl-CoA hydrolase EC 3.1.2.18: ADP-dependent short-chain-acyl-CoA ...

*List of EC numbers (EC 2)

... lyase) S-acetyltransferase EC 2.3.1.50: serine C-palmitoyltransferase EC 2.3.1.51: 1-acylglycerol-3-phosphate O-acyltransferase ... chondroitin 4-sulfotransferase EC 2.8.2.6: choline sulfotransferase EC 2.8.2.7: UDP-N-acetylgalactosamine-4-sulfate ... chondroitin 6-sulfotransferase EC 2.8.2.18: cortisol sulfotransferase EC 2.8.2.19: triglucosylalkylacylglycerol ...
hyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20 ...
Chondroitin ABC lyase (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase. This enzyme catalyses the following chemical reaction Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate. Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration. Yamagata, T.; Saito, H.; Habuchi, O.; Suzuki, S. (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243 (7): 1523-1535. PMID 5647268. Saito, H.; Yamagata, T.; Suzuki, S. (1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". J. Biol. Chem. 243 (7): 1536-1542. PMID 4231029. ...
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Alok:- thanks for the reply. But dude, do you even know what you said ? Society is all about freedom and survival- that is all written in the medieval sociology text books ( I have gotten hold of a few- like the ones by CWM and Durkheim,though Focault and MArx were far more apprehencive of the idea) Sir.I would recommend you to read Lenin for a change and I am sure you will understand what central idea guides things now-a-days.Also,do check out the basic Buddhist philosophy-"Nothing is static- the only fact that is permanent is the change itself"- beautiful isnt it? How do you think you can quote internal mechanism to be static in the face of this all.Infact, tell you what..You first read those books and get back to me.You will find all what needs to be known ...
Tenacibaculum maritimum is a devastating bacterial pathogen of wild and farmed marine fish with a broad host range and a worldwide distribution. We report here the complete genome sequence of the T. maritimum type strain NCIMB 2154T. The genome consists of a 3,435,971-base pair circular chromosome with 2,866 predicted protein-coding genes. Genes encoding the biosynthesis of exopolysaccharides, the type IX secretion system, iron uptake systems, adhesins, hemolysins, proteases, and glycoside hydrolases were identified. They are likely involved in the virulence process including immune escape, invasion, colonization, destruction of host tissues, and nutrient scavenging. Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro.
Purpose: To evaluate the potential of a bioactive coating based on chondroitin sulfate (CS) and tethered epidermal growth factor (EGF) for the improvement of healing around stent-grafts (SG). Methods: The impact of the bioactive coating on cell survival was tested in vitro on human vascular cells using polyethylene terephtalate films (PET) as a substrate. After being transferred onto a more "realistic" material (expanded poly(tetrafluoroethylene), ePTFE), the durability and mechanical behavior of the coating in addition to cell survival were studied. Preliminary in vivo testing was performed in a canine iliac aneurysm model reproducing type I endoleaks (3 animals with 1 control and 1 bioactive SG for each). Results: The CS and EGF coatings significantly increased survival of human smooth muscle cells and fibroblasts, compared with bare PET or ePTFE (P,.05). The coating also displayed good durability over 30 days according to ELISA and cell-survival tests. The coating did not affect the ...
Chondroitinase ABC is an enzyme from Bacteroides thetaiotaomicron that cleaves the endo-1,4-β-galactosaminic bonds between acetylgalactosamine and either glucuronic or i
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I thought these nutraceuticals were a bunch of boloney until, with no other management changes, my friends gelding went from lame at a walk to sound at a trot - he had been lame for some time with arthritis. (he is on chondroitin sulfate) What else is out there worth trying, and AERC legal? Maybe something to keep my muscles from getting so sore/stiff after a ride. Shelly in DE ...
|p|Chondroitin occurs next to cartilage tissue in connective tissue, tendons and skin. In relatively small quantities, chondroitin is absorbed through anima
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Chondroitin is a chemical naturally present in the connective tissues of humans and animals. It is mainly used for the treatment of osteoarthritis. The following article provides information about the various side effects of this chemical.
Chondroitin is a naturally occurring substance formed of sugar chains. Chondroitin is believed to help the body maintain fluid and flexibility in the joints.
Therapy. There are 13 Chapters to deeply display the global Chondroitin and Hyaluronic Acid market.. Chapter 1, to describe Chondroitin and Hyaluronic Acid Introduction, product scope, market overview, market opportunities, market risk, market driving force;. Chapter 2, to analyze the top manufacturers of Chondroitin and Hyaluronic Acid, with sales, revenue, and price of Chondroitin and Hyaluronic Acid, in 2015 and 2016;. Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2015 and 2016;. Chapter 4, to show the global market by regions, with sales, revenue and market share of Chondroitin and Hyaluronic Acid, for each region, from 2011 to 2016;. Chapter 5, 6, 7 and 8, to analyze the key regions, with sales, revenue and market share by key countries in these regions;. Chapter 9 and 10, to show the market by type and application, with sales market share and growth rate by type, application, from 2011 to 2016;. Chapter 11, Chondroitin ...
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Clinical experience likewise suggests that some dogs and cats may appreciably benefit from chondroitin administration and others not at all. It is difficult to anticipate which animals are most likely to respond. Given the potential for benefit and the extremely low risk of any adverse side effects, chondroitin supplementation is always recommended for animals with joint pain. Where a benefit is seen, doses of more expensive and potentially deleterious drugs may be reduced, including the NSAIDs (non steroidal anti-inflammatory drugs) such as aspirin, carprofen and meloxicam. Because chondroitin protects mucosal barriers, it may not only enhance pain relief in animals administered NSAIDS, but help protect their intestinal tracts from ulcerations which are occasionally seen as a side effect of NSAID use.. Research in laboratory animals suggests that chondroitin dissolved in water before administration is more effective than when administered within a capsule.. ...
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|p|Commonly taken as a complex, glucosamine, chondroitin and MSM are compounds that can work together to support healthy muscles and joints, working to relieve painful conditions such as osteoarthritis.|/p| |p|Glucosamine and chondroitin are produced nat
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Glucosamine, chondroitin, and Methyl sulfonylmethane, or MSM, are supplements commonly used to manage the pain associated with osteoarthritis, according to WebMD. However, scientific studies have...
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Chondroitin is a supplement frequently paired with Glucosamine as a combination therapy to help with joint pain and stiffness, and other symptoms of osteoarthritis.
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Chondro Cal™ 95 is a low sodium form of chondroitin calcium extracted from common source materials. It has a chondroitin content of 95%, and is primaril...
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We are attempting to develop methods for the sequencing of glycosaminoglycans from their reducing end. Here we describe a procedure for the analysis of dermatan sulphate from pig skin. The glycosaminoglycan is released from its parent proteoglycan by exhaustive proteolysis by using both endo- and exo-peptidases. The amino group of the residual serine residue is conjugated with a p-hydroxyphenyl group, which in turn is iodinated with 125I (the Bolton-Hunter reagent, BHR). The ion-exchange-purified end-labelled dermatan sulphate is then degraded partially or completely by various enzymic or chemical means to yield fragments extending from the labelled serine residue to the point of cleavage. The various products are separated by gradient PAGE, detected by autoradiography and quantified by videodensitometry. Complete digestion with chondroitin ABC lyase affords the labelled fragment delta HexA-GalNAc(-SO4)-GlcA-Gal-Gal-Xyl-Ser(-BHR). The structure was confirmed by sequential degradation from the ...
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... - Supports Healthy Joint Function* Supports Elasticity of Joint Tissues* Chondroitin Sulfate is a glycosaminoglycan and is a normal component of many body tissues including articular cartilage.* Our Chondroiti
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Glucosamine sulphate and Chondroitin sulphate have been thoroughly studied for their positive actions helping to maintain healthy joints and connective tissue.. Reflex Glucosomine and Chondroitin is a health product that may have repair and maintenance properties on joints and tendons.. Ideal for sore knees, ankles, elbows and back. Can also be used as a preventative measure during heavy training.. Chondroitin may work synergistically with Glucosamine potentially enhancing its effects.. ...
It is not known what exactly to expect from a chondroitin overdose. However, as this eMedTV page discusses, an overdose is likely to cause stomach upset. This page covers other possible effects of an overdose on chondroitin, as well as treatment options.
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Description: Glucosamine Chondroitin from webber naturals helps relieve joint pain associated with osteoarthritic conditions. Glucosamine helps stop cartilage deterioration while reducing or eliminating pain and improving joint function and Chondroitin supports joint lubrication. Combined, Glucosamine Chondroitin is an
1 x Glucosamine Chondroitin £15.95 or 2 For £27.99 (£13.995 Each) Glucosamine has been thoroughly studied for its positive actions in helping to maintain healthy joints and connective tissue. Chondroitin may work synergistically to enhance it effects. What makes Reflex Glucosamine & Chondroitin different from the competition? Many companies offer tablets, but few offer capsules. Reflex capsules are easier to swallow and very easy for your body to digest.. ...
1 x Glucosamine Chondroitin £15.95 or 2 For £27.99 (£13.995 Each) Glucosamine has been thoroughly studied for its positive actions in helping to maintain healthy joints and connective tissue. Chondroitin may work synergistically to enhance it effects. What makes Reflex Glucosamine & Chondroitin different from the competition? Many companies offer tablets, but few offer capsules. Reflex capsules are easier to swallow and very easy for your body to digest.. ...
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Glucosamine with Chondroitin is a popular supplement used for "joint health." Ive actually taken it on and off for a number of years, whenever my knees start aching. Ill usually start taking a capsule or two per day and after 2-3 weeks I generally notice an improvement, and will discontinue taking it after a while.. Recently I started taking GC for neck pain. For almost a year Ive had chronic neck pain and stiffness. During a recent doctors exam, for a non-neck issue, I asked the PA about my neck pain and she said "Oh, its probably just some Arthritis." It sounded like she was saying "just get used to it.". I had a supply of Glucosamine and Chondroitin so I added it to my daily pill regimen, and a few weeks later I noticed that my neck wasnt botherin me very much. Just having a single day without it bothering me felt like a blessing, it had been bothering me so much. And now it seems to hardly bother me at all.. Glucosamine and Chondroitin is reputed to help build up cartilage-building and ...
Chondroitin sulfate is one of the major constituents of cartilage. Chondroitin sulfate consists of repeating chains of molecules called mucopolysaccharides
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Glucosamine is the main molecule used by the body for building cartilage. Glucosamine supplements, alone or in combination with chondroitin or MSM, have been studied and shown to reduce joint pain and to improve joint function. Chondroitin is present in cartilage and connective tissue. It helps attract fluid to lubricate and cushion joints; MSM is a naturally occurring sulphur compound found in our bodies to relieve joint pain associated with osteoarthritis. ...
NOW® Glucosamine, Chondroitin & MSM combines three of the most popular and effective nutrients for supporting joint health in one dietary supplement. Our Glucosamine and Chondroitin are both 100% sulfate, the most studied form of these nutrients. In addition, we also include MSM (Methylsulphonylmethane), an organic form of sulfur found in all living organisms. Studies have shown that these nutrients provide dietary components that support healthy joint structure and function.*
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|p|Glucosamine Chondroitin from webber naturals helps relieve joint pain associated with osteoarthritic conditions. Glucosamine helps stop cartilage deterioration while reducing or eliminating pain and improving joint function and Chondroitin supports joi
Is joint stiffness from osteoarthritis holding you back? Glucosamine and chondroitin provide natural support for the structural integrity of joints and connective tissue and may help to keep your joints flexible, mobile, cushioned, and lubricated. By replenishing the synovial fluid that keeps your cartilage, ligaments, and tendons soft and flexible, glucosamine and chondroitin may provide pain relief.
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During development and regenerative growth, neuronal pathways are defined in part by several endogenous cues that collectively determine directed growth. The interactions between such cues largely are unknown. To address potential interactions, we have examined in vitro the combined effect on nerve growth of two endogenous growth cone guidance cues: chondroitin sulphate proteoglycans and weak dc electric fields. Addition to the culture medium of a chondroitin 6-sulphate/keratan sulphate containing PG (BNC-PG) markedly enhanced the cathodal re-orientation of embryonic Xenopus neurites in an electric field, whereas a proteoglycan containing chondroitin 4-sulphate (RC-PG) was inhibitory. These effects of BNC-PG and RC-PG were reproduced by their chondroitin sulphate glycosaminoglycan side chains alone. Chondroitin 6-sulphate or chondroitin 4-sulphate, respectively, enhanced and inhibited cathodally-directed nerve re-orientation. This was dependent on the integrity of the glycosaminoglycan chain ...
Glucosamine + Chondroitin with MSM Healthy cartilage strength and resilience Sulfur-containing methylsulfonylmethane (MSM) is included in this glucosamine and chondroitin combination to provide an enhanced spectrum of nutrients for optimal cartilage matrix composition, connective tissue strength, and joint comfort. Glucosamine promotes the synthesis of the glycosaminoglycan chondroitin sulfate. Chondroitin sulfate is responsible for building the ground substance of cartilage, molecules known as proteoglycans. In addition, chondroitin sulfate may maintain healthy enzyme activity. An important role of sulfur from MSM is to enhance the structure and integrity of proteoglycans. Pure Encapsulations Glucosamine and Chondroitin with MSM offers highly purified constituents for healthy cartilage formation and joint movement ease. Supplement Facts: Amount Per Serving each vegetable capsule contains: glucosamine HCl (crab, shrimp), 99% 300 mg. chondroitin sulfate (bovine), 95% 300 mg. MSM
Glucosamine + Chondroitin with Manganese Enhanced cartilage synthesis and antioxidant support This convenient formula combines two of the most important cartilage building blocks, glucosamine and chondroitin, with manganese ascorbate for enhanced connective tissue support. Glucosamine promotes the synthesis of glycosaminoglycans, such as chondroitin sulfate. The primary structural compound of articular cartilage, chondroitin sulfate also helps to block the activity of degradative enzymes. Together, glucosamine and chondroitin may provide synergistic support for healthy hyaluronic acid content and synovial fluid. The trace mineral manganese plays a key role in supporting glycosaminoglycan and mucopolysaccharide production and encourages the antioxidant activity of superoxide dismutase. Ascorbate is a vital nutrient for proper collagen formation and also serves as an antioxidant. In a recent study, the combination of glucosamine HCl, chondroitin sulfate and manganese ascorbate demonstrated the
Chondroitin sulfate: Find the most comprehensive real-world treatment information on Chondroitin sulfate at PatientsLikeMe. 5 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Chondroitin sulfate.
Chondroitin is responsible for keeping the joint cartilage lubricated by absorbing water and providing the building blocks for new cartilage. It helps alleviate symptoms of osteoarthritis. Chondroitin is anti-inflammatory it helps reduce swelling around joints and prevents the degradation of joint cartilage. Chondroitin is usually taken together with glucosamine sulfate ...

Chondroitin ABC lyase - WikipediaChondroitin ABC lyase - Wikipedia

Chondroitin ABC lyase (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic ... Chondroitin ABC lyase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... name chondroitin ABC lyase. This enzyme catalyses the following chemical reaction Eliminative degradation of polysaccharides ... chondroitin 6-sulfate and dermatan sulfate. Following a spinal cord injury, this enzyme can be used to erode scar tissue that ...
more infohttps://en.wikipedia.org/wiki/Chondroitin_ABC_lyase

Frontiers | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence...Frontiers | The Complete Genome Sequence of the Fish Pathogen Tenacibaculum maritimum Provides Insights into Virulence...

... a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro. ... a sphingomyelinase and a chondroitine AC lyase which activities were demonstrated in vitro. ... Chondroitin AC Lyase In Vitro Activity. The native chondroitin AC lyase activity of T. maritimum was assayed in vitro according ... Chondroitin AC Lyase and Sphingomyelinase Cloning, Expression, and Enzymatic Activity. The genes encoding the chondroitin AC ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2017.01542/full

The transforming growth factor-beta receptor type III is a membrane pr by Sela Cheifetz, Janet L. Andres et al."The transforming growth factor-beta receptor type III is a membrane pr" by Sela Cheifetz, Janet L. Andres et al.

Thus, the type III TGF-beta receptor has the properties of a membrane proteoglycan that carries heparan and chondroitin sulfate ... Chondroitin Lyases; Chromatography, Ion Exchange; Glycoside Hydrolases; Polysaccharide-Lyases; Rats; Receptors, Cell Surface; ... Thus, the type III TGF-beta receptor has the properties of a membrane proteoglycan that carries heparan and chondroitin sulfate ...
more infohttps://escholarship.umassmed.edu/oapubs/888/

Chondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides | SpringerLinkChondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides | SpringerLink

Chondroitin sulfate (CS) saccharides from cartilage tissues have potential application in medicine or as dietary supplements ... Chondroitin sulfate Chondroitin sulfate lyase Marine Arthrobacter sp. This is a preview of subscription content, log in to ... Chondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides. ... As the recombinant chondroitin sulfate lyase (designated as ChoA1R) degraded chondroitin sulfate efficiently compared to a ...
more infohttps://link.springer.com/article/10.1007%2Fs10126-015-9629-9

Chondroitin B lyase - WikipediaChondroitin B lyase - Wikipedia

In enzymology, a chondroitin B lyase (EC 4.2.2.19) is an enzyme that catalyzes the chemical reaction Eliminative cleavage of ... The systematic name of this enzyme class is chondroitin B lyase. Other names in common use include chondroitinase B, ChonB, and ... Gu K, Linhardt RJ, Laliberte M, Gu K, Zimmermann J. "Purification, characterization and specificity of chondroitin lyases and ... V, Sasisekharan R, Cygler M (2004). "The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides ...
more infohttps://en.wikipedia.org/wiki/Chondroitin_B_lyase

HKU Scholars Hub: Factors underlying improved efficacy of chondroitin sulphate lyases in overcoming chondroitin sulphate...HKU Scholars Hub: Factors underlying improved efficacy of chondroitin sulphate lyases in overcoming chondroitin sulphate...

Conference Paper: Factors underlying improved efficacy of chondroitin sulphate lyases in overcoming chondroitin sulphate ... Factors underlying improved efficacy of chondroitin sulphate lyases in overcoming chondroitin sulphate barriers for nerve ... Factors underlying improved efficacy of chondroitin sulphate lyases in overcoming chondroitin sulphate barriers for nerve ...
more infohttp://hub.hku.hk/handle/10722/153010

Chondroitin ABC lyase from Bacteroides thetaiotaomicron, Recombinant(EC 4.2.2.20) - Creative EnzymesChondroitin ABC lyase from Bacteroides thetaiotaomicron, Recombinant(EC 4.2.2.20) - Creative Enzymes

... chondroitin ABC lyase; chondroitin sulfate ABC lyase; ChS ABC lyase; chondroitin sulfate ABC endoeliminase; chondroitin sulfate ... Chondroitin ABC lyase from Bacteroides thetaiotaomicron, Recombinant. Chondroitin ABC lyase from Bacteroides thetaiotaomicron, ... Chondroitin sulfate A (CS-A), chondroitin sulfate B (CS-B), chondroitin sulfate C (CS-C), chondroitin (C), and H ... Cystathionine-β-Synthase/Lyase Industrial Enzyme Production Enzyme Engineering and Modification Creatinase/Creatininase/ ...
more infohttps://www.creative-enzymes.com/product/Chondroitin-ABC-Lyase-From-Bacteroides-Thetaiotaomicron-Recombinant_3750.html

Sodium in the structure of Crystal Structure of Arthrobacter Aurescens Chondroitin Ac Lyase (pdb 1rwc)Sodium in the structure of Crystal Structure of Arthrobacter Aurescens Chondroitin Ac Lyase (pdb 1rwc)

Crystal Structure of Arthrobacter Aurescens Chondroitin Ac Lyase ... Structure of Arthrobacter Aurescens Chondroitin Ac Lyase (pdb ... The binding sites of Sodium atom in the structure of Crystal Structure of Arthrobacter Aurescens Chondroitin Ac Lyase (pdb code ...
more infohttp://sodium.atomistry.com/pdb1rwc.html

HKU Scholars Hub: Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injuryHKU Scholars Hub: Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injury

chondroitin sulphate lyases. -. dc.title. Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve ... Conference Paper: Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injury. *Show simple item ... Chondroitin sulphate ABC lyases (ChABC) from Proteus vulgaris have been exploited to cleave CS moieties in the injured ... Chondroitin sulphate ABC lyases (ChABC) from Proteus vulgaris have been exploited to cleave CS moieties in the injured ...
more infohttp://hub.hku.hk/handle/10722/153012

Sodium in the structure of Crystal Structure of Chondroitin Abc Lyase I From Proteus Vulgaris At 1.9 Angstroms Resolution (pdb...Sodium in the structure of Crystal Structure of Chondroitin Abc Lyase I From Proteus Vulgaris At 1.9 Angstroms Resolution (pdb...

Crystal Structure of Chondroitin Abc Lyase I From Proteus Vulgaris At 1.9 Angstroms Resolution ... The binding sites of Sodium atom in the structure of Crystal Structure of Chondroitin Abc Lyase I From Proteus Vulgaris At 1.9 ... Sodium in the structure of Crystal Structure of Chondroitin Abc Lyase I From Proteus Vulgaris At 1.9 Angstroms Resolution (pdb ...
more infohttp://sodium.atomistry.com/pdb1hn0.html

Pedobacter heparinus (Payza and Korn) Stein et al. ATCC ® 13125&trPedobacter heparinus (Payza and Korn) Stein et al. ATCC ® 13125&tr

Degrades heparin Produces chondroitin lyases chondoitinase AC II Produces sulfoesterase Produces sulphoglucosamine sulphamidase ... Produces chondroitin lyases chondoitinase AC II. Produces sulfoesterase. Produces sulphoglucosamine sulphamidase sulphamidase ...
more infohttps://www.atcc.org/products/all/13125.aspx

TNO Repository search for: subject:Receptors, ThrombinTNO Repository search for: subject:'Receptors, Thrombin'

... chondroitin ABC lyase, 9024-13-9; thrombin, 9002-04-4; thrombomodulin, 112049-68-0; urokinase, 139639-24-0; Chondroitin Lyases ... chondroitin 4 sulfate · chondroitin abc lyase · glycosaminoglycan · mutant protein · thrombomodulin · urokinase · dissociation ... Chondroitin Lyases · Dose-Response Relationship, Drug · Glycosaminoglycans · Glycosylation · Human · Receptors, Cell Surface · ... The free glycosarninoglycans obtained by alkaline treatment of TM or chondroitin sulphate A also accelerated the inactivation ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject%3A%22Receptors%2C%20Thrombin%22

A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been...A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Regimens in HIV Infected Patients Who Have Never Been...

Chondroitinases And Chondroitin Lyases. Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, ... Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate ... Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. ... Chondroitin Sulfates. Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of ...
more infohttps://www.bioportfolio.com/resources/trial/127701/A-Study-to-Evaluate-the-Long-Term-Effectiveness-of-Three-Anti-HIV.html

Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill ChildrenSafety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children

Chondroitinases And Chondroitin Lyases. Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, ... Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate ... Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. ... Chondroitin Sulfates. Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of ...
more infohttps://www.bioportfolio.com/resources/trial/68266/Safety-and-Dose-Escalation-Study-of-Zinc-Supplementation-in-Critically-Ill-Children.html

A hierarchical classification of polysaccharide lyases for glycogenomics | Biochemical JournalA hierarchical classification of polysaccharide lyases for glycogenomics | Biochemical Journal

... hyaluronate lyase (EC 4.2.2.1), xanthan lyase (EC 4.2.2.12) and chondroitin AC lyase (EC 4.2.2.5). Here, the common names of ... A) syn-Elimination, as in chondroitin lyase. (B) anti-Elimination, as in α-(1,4)-polygalacturonan (pectate) lyase. In both, ... A) hyaluronan, (B) chondroitin (R=R′=H) and chondroitin sulfates A (R=SO3−, R′=H) and C (R=H, R′=SO3−), and (C) xanthan. The ... 2006) An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase. ChemBioChem 7:631-637. ...
more infohttp://www.biochemj.org/content/432/3/437.long

Proteoglycan Protocols | Springer for Research & DevelopmentProteoglycan Protocols | Springer for Research & Development

Degradation of Chondroitin Sulfate and Dermatan Sulfate with Chondroitin Lyases MarÍa José Hernáiz, Robert J. Linhardt ... Disaccharide Composition of Hyaluronan and Chondroitin/Dermatan Sulfate Anna H. K. Plaas, L. West, Ronald J. Midura, Vincent C ... Detection of Proteoglycan Core Proteins with Glycosaminoglycan Lyases and Antibodies John R. Couchman, Pairath Tapanadechopone ...
more infohttps://rd.springer.com/book/10.1385/1592592090

KEGG ENZYME: 4.2.2.19KEGG ENZYME: 4.2.2.19

The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic ... Purification, characterization and specificity of chondroitin lyases and glycuronidase from Flavobacterium heparinum. ... This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required ... Isolation and expression in Escherichia coli of cslA and cslB, genes coding for the chondroitin sulfate-degrading enzymes ...
more infohttps://www.genome.jp/dbget-bin/www_bget?ec:4.2.2.19

Age-Related Changes in Populations of Aortic Glycosaminoglycans | Arteriosclerosis, Thrombosis, and Vascular BiologyAge-Related Changes in Populations of Aortic Glycosaminoglycans | Arteriosclerosis, Thrombosis, and Vascular Biology

Chondroitin AC lyase (EC 4.2.2.5) from Arthrobacter aurescens and chondroitin ABC lyase (EC 4.2.2.4) from Proteus vulgaris were ... Digestion with chondroitin AC lyase yielded proportions of isomeric chondroitin 4-sulfate and chondroitin 6-sulfate (Fig 3D⇑) ... Glycosaminoglycans (100 μg) were incubated with 10 mU chondroitin AC lyase or chondroitin ABC lyase in 100 μL of 50 mmol/L Tris ... After incubation of the dermatan sulfate+chondroitin 4/6-sulfate with chondroitin AC lyase (see "Methods"), the mixtures were ...
more infohttp://atvb.ahajournals.org/content/18/4/604

Age-related changes in the chemical composition of bovine articular cartilage. The structure of high-density proteoglycans |...Age-related changes in the chemical composition of bovine articular cartilage. The structure of high-density proteoglycans |...

Buffer induced modification of 6-sulfated disaccharide in chondroitin lyase digestions *David P. Norby ... Isolation and some structure analyses of a copolymeric chondroitin sulfate-dermatan sulfate proteoglycan from post-burn, human ...
more infohttps://portlandpress.com/biochemj/crossref-citedby/17312

Ólafur H. Friðjónsson | Starfsfólk og símanúmer | MatísÓlafur H. Friðjónsson | Starfsfólk og símanúmer | Matís

Chondroitin Lyase from a Marine Arthrobacter sp. MAT3885 for the Production of Chondroitin Sulfate Disaccharides. Marine ... Erindi 47: Cloning and expression of a chondroitin lyase gene from the marine bacterium Arthrobacter MAT3885 and ...
more infohttps://www.matis.is/matis/mannaudur/starfsfolk-og-simanumer/persona/51/fyrirtaeki/1

Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.

Chondroitin ABC Lyase / metabolism. Chondroitin Sulfates / chemistry. Cytokines / metabolism. Epidermal Growth Factor / ... 9007-28-7/Chondroitin Sulfates; EC 4.2.2.20/Chondroitin ABC Lyase ... Neuroglycan C lacking chondroitin sulfate chains was eluted with 0.5 m NaCl as a major fraction from the column. We confirmed ... Among three functional domains of the extracellular part of neuroglycan C, the chondroitin sulfate attachment domain and acidic ...
more infohttp://www.biomedsearch.com/nih/Neuroglycan-C-novel-midkine-receptor/16901907.html

CATH Superfamily 1.50.10.100CATH Superfamily 1.50.10.100

Chondroitin AC/alginate lyase. The name of this superfamily has been modified since the most recent official CATH+ release (v4_ ...
more infohttp://www.cathdb.info/version/latest/superfamily/1.50.10.100

Frontiers | Environmental and Gut Bacteroidetes: The Food Connection
 | MicrobiologyFrontiers | Environmental and Gut Bacteroidetes: The Food Connection | Microbiology

In a study of the fish pathogen F. columnare, a chondroitin lyase was found to be related to the virulence (Suomalainen et al ... Suomalainen, L.-R., Tiirola, M., and Valtonen, E. T. (2006). Chondroitin AC lyase activity is related to virulence of fish ... Indeed, phytopathogenic strains of F. johnsoniae secrete much more pectate lyase than their non pathogenic counterparts (Liao ... Animal pathogens produce a range of hydrolytic enzymes such as hyaluronidase, chondroitin sulfatase, heparinase, glucosidases, ...
more infohttps://www.frontiersin.org/articles/10.3389/fmicb.2011.00093/full

keratanase II
     Summary Report | CureHunterkeratanase II Summary Report | CureHunter

Chondroitin ABC Lyase CureHunter Inc. provides medical information and specifically does NOT provide medical advice. ...
more infohttp://www.curehunter.com/public/keywordSummaryC086950-keratanase-II.do

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (Aggrecans); 0 (RNA, Messenger); EC 4.2.2.20 (Chondroitin ABC Lyase). [Em] M s de entrada:. 1712. ... The administration of chondroitinase ABC degrades these chondroitin sulfate proteoglycans and improves functional recovery ... CONCLUSIONS: Significant upregulation of chondroitin sulfate proteoglycans and other extracellular matrix components ... and quantitative immunohistochemical analyses were performed to determine levels of chondroitin sulfate proteoglycans and ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=C10.668.829.712
  • Following assembly and annotation, an orf, annotated as family 8 polysaccharide lyase genes, was identified, encoding an amino acid sequence with a similarity to CS lyases according to NCBI blastX. (springer.com)
  • Among the predicted virulence factors, type IX secretion-mediated and cell-surface exposed proteins were identified including an atypical sialidase, a sphingomyelinase and a chondroitin AC lyase which activities were demonstrated in vitro . (frontiersin.org)
  • Chondroitin sulfate (CS) saccharides from cartilage tissues have potential application in medicine or as dietary supplements due to their therapeutic bioactivities. (springer.com)