Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
Membrane proteins that are involved in the active transport of phosphate.
A group of nine islands and several islets belonging to Portugal in the north Atlantic Ocean off the coast of Portugal. The islands are named after the acores, the Portuguese for goshawks, living there in abundance. (Webster's New Geographical Dictionary, 1988, p102 & Room, Brewer's Dictionary of Names, 1992, p42)
An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).
The at-home administering of nutrients for assimilation and utilization by a patient who cannot maintain adequate nutrition by enteral feeding alone. Nutrients are administered via a route other than the alimentary canal (e.g., intravenously, subcutaneously).
A disease of elderly men characterized by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions.
Inorganic salts of phosphoric acid that contain two phosphate groups.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
The articulation between a metacarpal bone and a phalanx.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
Roentgenography of a joint, usually after injection of either positive or negative contrast medium.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Excision of one or more of the parathyroid glands.
The interarticular fibrocartilages of the superior surface of the tibia.
Endoscopic examination, therapy and surgery of the joint.
Injuries to the knee or the knee joint.
The musculotendinous sheath formed by the supraspinatus, infraspinatus, subscapularis, and teres minor muscles. These help stabilize the head of the HUMERUS in the glenoid fossa and allow for rotation of the SHOULDER JOINT about its longitudinal axis.
The fluid secreted by the lacrimal glands. This fluid moistens the CONJUNCTIVA and CORNEA.
A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.
Breaks in CARTILAGE.

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (1/143)

A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported.  (+info)

Chondrocalcinosis after parathyroidectomy. (2/143)

In this retrospective study of 57 patients with primary hyperparathyroidism who underwent parathyroidectomy, the overall incidence of chondrocalcinosis was 40%. Neither joint symptoms nor chondrocalcinosis regressed after the operation. In several patients the condition appeared to deteriorate both clinically and radiologically after the operation, while in a few both the chondrocalcinosis and the associated symptoms first appeared some time after the operation.  (+info)

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (3/143)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Elevated parathyroid hormone 44-68 and osteoarticular changes in patients with genetic hemochromatosis. (4/143)

OBJECTIVE: To determine whether the osteoarticular changes associated with genetic hemochromatosis could be explained by metabolic parathyroid hormone (PTH) disorders. METHODS: The study involved 210 patients with liver iron overload syndromes. Osteoarticular changes were numerically scored as the number of damaged joints. PTH 1-84 and 44-68 were assayed. RESULTS: An increase in serum PTH 44-68 levels was found in one-third of untreated patients who had no calcium or PTH 1-84 abnormalities. Serum PTH 44-68 levels correlated positively with serum ferritin levels. In multivariate analyses, the number of affected joints correlated positively with age, serum PTH 44-68 levels, and serum ferritin levels. CONCLUSION: Liver iron overload syndromes, especially genetic hemochromatosis, are associated with elevated circulating levels of PTH fragments containing the 44-68 region, which appears to play a role in osteoarticular changes. This increase seems to be a consequence of iron overload.  (+info)

Phosphocitrate blocks nitric oxide-induced calcification of cartilage and chondrocyte-derived apoptotic bodies. (5/143)

OBJECTIVE: To examine whether phosphocitrate (PC) will block nitric oxide-induced calcification of cartilage or chondrocyte-derived apoptotic bodies. DESIGN: Articular cartilage vesicles (ACV) or apoptotic bodies (AB) were isolated from untreated or 1mM sodium nitroprusside (SNP) treated porcine cartilage slices. Mineralization of ACV, AB, control untreated and SNP-treated cartilage were done in the presence or absence of PC (1mM)+/-ATP (1mM). RESULTS: PC [1mM] blocked both the ATP-dependent and -independent mineralization in ACV and AB, untreated and SNP treated cartilage. Moreover, PC had no effect on NTPPPH activity in either ACV or AB fraction in the presence or absence of ATP suggesting that PC did not block the mineralization through the inhibition of NTPPPH activity. CONCLUSIONS: PC inhibits nitric oxide-induced calcification of cartilage and cartilage-derived apoptotic bodies.  (+info)

Most calcium pyrophosphate crystals appear as non-birefringent. (6/143)

OBJECTIVE: To determine the proportion of calcium pyrophosphate dihydrate (CPPD) crystals that appear as non-birefringent when observed under the polarised light microscope. METHODS: Two observers examined independently 10 synovial fluid samples obtained during an episode of arthritis attributable to CPPD crystals. Ten synovial fluid samples from patients with acute gout were used as a reference. The examination was performed after placing a fluid sample in a Niebauer haemocytometric chamber; a crystal count was done first under ordinary light, then in the area corresponding to a 0.1 ml, under polarised light RESULTS: The percentages of birefringence appreciated for CPPD were 18% (confidence intervals (CI) 12, 24) for observer 1, and 17% (CI 10, 24) for observer 2 (difference NS). The percentages of birefringence for monosodium urate were 127% (CI 103, 151) for observer 1 and 107% (CI 100, 114) for observer 2 (difference NS). Percentages above 100% indicate that crystals missed under ordinary light became apparent under polarised light. CONCLUSION: Only about one fifth of all CPPD crystals identified by bright field microscopy show birefringence when the same synovial fluid sample is observed under polarised light. If a search for CPPD crystals is conducted under polarised light, the majority of the crystals will be missed. Ordinary light allows a better rate of CPPD crystal detection but observation under polarised light of crystals showing birefringence is required for definitive CPPD crystal identification.  (+info)

Exclusion of the gene for human cartilage intermediate layer protein in currently mapped calcium pyrophosphate dihydrate deposition syndromes. (7/143)

OBJECTIVE: To map the gene for human cartilage intermediate layer protein (CILP) in order to assess its involvement in some familial forms of calcium pyrophosphate dihydrate (CPPD) deposition disease. METHODS: A radiation hybrid panel was analyzed for chromosomal assignment of the CILP gene within a 1-cM limit of resolution. The location of the gene for CILP was confirmed to reside at the observed radiation hybrid locus by fluorescence in situ hybridization. RESULTS: The human CILP gene resides at chromosome 15q21. CONCLUSION: This map location definitively excludes mutations in the CILP gene as the cause of certain familial forms of CPPD deposition disease that have been genetically mapped to chromosomes 8q and 5p.  (+info)

Seasonal variation in the onset of acute microcrystalline arthritis. (8/143)

OBJECTIVE: To determine whether acute attacks of uric acid and calcium pyrophosphate microcrystalline arthritis show a seasonal variation and, if so, to verify whether the distribution of single episodes shows a rhythmic circannual pattern. METHOD: All suspected cases of microcrystalline acute arthritis observed at the General Hospital of Ferrara during an 8 yr period (January 1990-December 1997) were considered. Diagnosis was made on the basis of history, physical examination and analysis of synovial fluid by means of polarized light microscopy. Month and day of each event were categorized both into four 3-month periods (by seasons) and 12 monthly intervals. Two different statistical methods have been utilized: chi(2) test for goodness of fit and partial Fourier series. RESULTS: During the period considered, 210 episodes of acute gout were observed [196 in males (93.3%) and 14 in females (6.7%)] in 179 different subjects, and 179 episodes of acute pseudogout [58 in males (32.4%) and 121 in females (67.6%)] in 165 different subjects. Gout attacks showed a higher frequency peak in spring [76 cases (36. 2%), P<0.001]. Analysis of distribution of events by gender confirmed the clear spring pattern in males (36.2%), whereas the paucity of cases in females did not allow any valid statistical analysis. Pseudogout attacks showed a higher frequency peak in autumn [52 cases (29.1%)], without reaching a statistically significant level either for the total sample or for subgroups divided by gender. Analysis of the seasonal distribution of gout or pseudogout events was significantly different (chi(2) 15.7, P=0.001). Chronobiological evaluation by means of Fourier analysis showed a circannual pattern for gout attacks, both for the total sample (P=0.006) and the male subgroup (P=0.003), characterized by a peak in April and a trough in October. Again, as for pseudogout events, no seasonal variation was found, either for the total sample or subgroups by gender. CONCLUSIONS: The present study gives further confirmation that acute gout attacks exhibit a circannual distribution in their occurrence, being more frequent in April, whereas pseudogout attacks do not. Moreover, the seasonal distribution of gout and pseudogout acute events is significantly different.  (+info)

The diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) until recent years has been mainly based on the finding of typical crystals of calcium pyrophosphate dihydrate (CPP) in the synovial fluid of affected patients and on the presence of typical calcifications on plain X-rays ...
Calcium pyrophosphate dihydrate crystals are associated with a range of clinical syndromes, which have been given various names, based upon which clinical symptoms or radiographic findings are most prominent.[11] A task force of the European League Against Rheumatism (EULAR) made recommendations on preferred terminology.[5] Accordingly, calcium pyrophosphate deposition (CPPD) is an umbrella term for the various clinical subsets, whose naming reflects an emphasis on particular features. For example, pseudogout refers to the acute symptoms of joint inflammation or synovitis: red, tender, and swollen joints that may resemble gouty arthritis (a similar condition in which monosodium urate crystals are deposited within the joints). Chondrocalcinosis,[2][3] on the other hand, refers to the radiographic evidence of calcification in hyaline and/or fibrocartilage. Osteoarthritis (OA) with CPPD reflects a situation where osteoarthritis features are the most apparent. Pyrophosphate arthropathy refers to ...
Synonyms: Pseudogout, chondrocalcinosis, pyrophosphate arthropathy.. ICD-9 Codes: Pseudogout, 712.2; CPPD crystal deposition disease, 712.2; chondrocalcinosis, 712.3.. Definition: CPPD crystal deposition disease includes arthritic syndromes associated with CPPD crystal deposition disease in articular tissues. The following definitions are used here:. -Chondrocalcinosis: Calcification of articular cartilage (identified by x-ray).. -Chronic CPPD crystal deposition disease: Structural bone and cartilage abnormalities associated with intraarticular deposition of CPPD crystals.. -Pseudogout: Clinical syndrome of acute synovitis caused by intraarticular CPPD crystal deposition, the most common form of CPPD crystal deposition disease.. Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. Some cases appear to be hereditary, whereas others are ...
In all cases, in the first group, in which both US and radiographs were positive for the presence of calcifications, a large number of either intra- or extracellular CPPD crystals were found. In one case where MSU crystals were found, no specific US signs were found. The patient presented moderate articular swelling and important functional limitation due to pain. The US picture showed effusion and mild synovitis of the wrist joint.. Pattern II was the most common (found in at least one site in all patients). The third pattern was found in one patient with a large effusion in the subacromial bursae, where several mobile hyperechoic deposits were seen. A large number of CPPD crystals was found in the synovial fluid analysis, so we believe that the third pattern is seen when crystal aggregates are formed.. To our knowledge, only a few studies on the use of US in CPPD disease have been carried out, mostly in the knee joint. In these studies, average sensitivity and specificity in detecting ...
Articular chondrocalcinosis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
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Pseudogout is a type of arthritis that, as the name implies, can cause symptoms similar to gout, but which are a reaction to a different type of crystal deposit. This type of arthritis may be one of the most misunderstood forms, and is often mistaken for gout and other conditions, including RA. Proper diagnosis is important because untreated pseudogout may lead to a severe form of joint degeneration and ongoing inflammation, resulting in chronic disability.. Pseudogout develops when deposits of calcium pyrophosphate crystals accumulate in a joint. Initially, crystals deposit in the cartilage and can cause damage. They also can cause a reaction with inflammation that leads to joint pain and swelling. This can cause more chronic arthritis that mimics osteoarthritis or RA. Knees are most often involved, but wrists, shoulders, ankles, elbows, and hands can be affected. Ultimately, a patient with pseudogout could be incapacitated for days or weeks.. ...
Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (SNPs) and radiographic CC. SNPs in ankylosis human (ANKH), high ferritin (HFE), tissue non-specific alkaline phosphatase (TNAP), ecto-neucleotide pyrophosphatase 1 (ENPP1), and transferrin (TE) genes were genotyped in participants of the Genetics of Osteoarthritis and Lifestyle (GOAL) and Nottingham Osteoarthritis Case-Control studies. Adjusted genotype odds ratio (aORGENOTYPE), the OR for association between one additional minor allele and CC, was calculated and adjusted for age, gender, body mass index (BMI), and osteoarthritis (OA) by using binary logistic regression. Statistical significance was set at P ≤0.003 after Bonferroni correction for multiple tests. The -4bpG | A polymorphism in the 5′ untranslated region (5′ UTR) of ANKH associated with CC after Bonferroni correction. This was
The crowned dens syndrome (CDS), also known as periodontoid calcium pyrophosphate dehydrate crystal deposition disease, is typified clinically by severe cervical pain, neck stiffness and atlantoaxial synovial calcification which could be misdiagnosed
Mohammad Sami Walid 1, Joshua C. Yelverton 2, Mohammed Ajjan 3, Arthur A. Grigorian 3. Medical Center of Central Georgia 1, Mercer University 2, Georgia Neurosurgical Institute 3, USA. Abstract. Objective & Importance: Crystal-induced arthritis (gout and pseudogout) usually affects peripheral joints whereas spine involvement with severe myelopathy is extremely rare. PubMed search yielded 42 results for gout myelopathy and 35 results for pseudogout myelopathy .. Clinical Presentation: We are reporting the case of a 62 years old female Caucasian who presented with severe thoracic myelopathy. MRI of the spine with contrast showed a 1.0´1.7 cm epidural soft tissue nodule with peripheral enhancement posterior to the thoracic cord at T9-10.. Intervention: Decompression and excision of the lesion was performed. Pathology revealed rhomboid-shaped, positively birefringent crystals. Uric acid was normal. The diagnosis of pseudogout was established.. Conclusion: Spinal crystal arthropathy should be ...
A matched case-control study was undertaken using data from the UK-Clinical Practice Research Datalink. Adults who consulted for incident acute pseudogout between 1987 and 2012 were each matched for gender, age at pseudogout diagnosis, and general practice to up to 4 control subjects without pseudogout. The exposure of interest was a prescription for an oral bisphosphonate issued within the 60-day period prior to the date of incident acute pseudogout. Associations between incident acute pseudogout and prior bisphosphonate prescription were examined using conditional logistic regression, adjusting for hyperparathyroidism, osteoarthritis, rheumatoid arthritis, hemochromatosis, hypophosphatasia, and prescriptions for diuretics and oral corticosteroids ...
Determine whether your pain and swelling is caused by pseudogout. Specialists at Brigham and Womens Hospital provide pseudogout diagnosis and treatment.
In need of more information about this disease if anyone has it. I am waiting for my informational appt with my doctor but am looking for info in the meantime. Questions are: what is prognosis? How does disease usually progress? DOES it usually spread to other joints, or is it impossible to know for sure if it wiil? Is it the same as pseudogout and CPPD or just associated with them..how does it differ? Is it a rheumatological disease or metabolic? Ive heard it described as both and Im not sure what the difference is. Thanks to anyone that can help me while I wait to see my doctor!. Reply Follow This Thread Stop Following This Thread Flag this Discussion ...
n. the appearance of calcific material in joint cartilage, most commonly an incidental finding on X-ray of the knees in elderly patients and usually causing no symptoms. It is also seen less commonly in several disorders, including Wilsons disease, pseudogout, hyperparathyroidism, hypothyroidism, and haemochromatosis. ...
Diagnosis Code M11.129 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
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New research findings reveal that Raman spectroscopy (RS) used at point of service could reduce the need for inpatient admission in patients with gout and pseudogout.
Dr. Alvin Wells answered: Pseudogout: Pseudogout mimics an inflammatory arthritis similar to that caused by gout. Gout is cau...
All clinicians know about the complexity in diagnosing rheumatoid arthritis (RA), especially early in the disease. Because RA lacks pathognomonic features - that is, there are no clinical, biological, or radiological characteristics specific to RA diagnosis - doubt about the diagnosis may persist for some patients1,2. Examples are patients with nude polyarthritis [i.e., without positivity for serum rheumatoid factor (RF), anti-citrullinated peptide antibodies, typical erosion, or all 3], or even elderly people with erosive RF-positive polyarthritis associated with psoriasis or calcium crystal deposition disease features seen on joint radiography. When RA is neither obvious nor completely excluded, the clinician strikes a balance between possible or probable RA, depending on the level of confidence. In this context, in clinical research, RA classification criteria may be of some help because they ensure, at the group level, the diagnosis of RA with minimal error. However, in clinical practice, ...
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The distal tibio-fibular joint ( DTFJ) be an integral part of the ankle and its injury makes all the gravity, forecast and complexity of ankle fracture treatment. Its classically described and known by radiological point of view, but in static incidence and from anatomical studies. To our knowledge the dynamic dimension and its modelling is missing. Our study will use high spatial-resolution MRI acquisition to obtain the best possible definition of DTFJ but especially it will be associated with MRI acquisition in movement, using typical fast sequences TrueFISP and FLASH which will allow a precise modelling of joint physiological movements and biomechanics on healthy subjects by a not invasive method. This analysis will be made on a simple movement of flexion and extension, the other possible movements of the ankle being blocked what corresponds to the clinical situation of an osteosynthesis ankle immobilized in post-operative by a dynamic rehabilitation shoe Axmed ® It will be associated ...
Klasszikus Bartter-szindr ma: Csecsem illetve fiatal gyermekkorban kezd d polydipsia, polyuria, nycturia, generaliz lt izomgyenges g, izomg rcs k s n veked si retard ci jellemzi. Pseudo-Bartter-szindr ma: Diuretikum abusus eset n kialakul , a klasszikus Bartter-szindr m hoz megt veszt sig hasonl t t netegy ttes. Gitelman-szindr ma: Enyh bb klinikai t netek, leggyakrabban gyermek s fiatal feln tt korban jelentkezik hypokaliaemia t neteivel. Az izomgyenges gen k v l hypomagnesaemi s izomg rcs k s chondrocalcinosis miatti iz leti f jdalmak l pnek fel. Jellemz je m g: hypocalcaemia, alkalosis, tetania. Antenatalis Bartter-szindr ma (hyperprostaglandin-E szindr ma): Renalis, tubularis, hypokalaemi s alkalosis s k vetkezm nyes sziszt m s k rosod sok jellemzik. T pusos t nete a magzati polyuria miatt kialakul hydramnion. Gyakran fordul el korasz l s ...
Learn more about Calcium Pyrophosphate Dihydrate Deposition Disease at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Calcium deposition is often seen at the triangular fibrocartilage of the wrist. Subchondral sclerosis, joint space narrowing, subchondral cyst formations which may be quite large, and intraarticular bodies from subchondral osseous collapse and fragmentation are all findings which can be seen in patients with CPPD disease. These radiographic abnormalities are most common at the radiocarpal articulation and at the 2nd and 3rd metacarpophalangeal joints. Additionally, there may a shift in the normal alignment of the scaphoid and lunate and narrowing at the midcarpal compartment. Differential Diagnosis:. CPPD disease causes destruction of cartilage which can lead to radiographic findings similar to osteoarthritis. Sites of involvement are useful for differentiating the two since the radiocarpal compartment of the wrist is not a common location for osteoarthritis. Lack of an erosive process at the MCP joint differentiates CPPD crystal deposition disease from rheumatoid arthritis. Greater propensity ...
Milwaukee shoulder syndrome (apatite-associated destructive arthritis) is a rheumatological condition similar to calcium pyrophosphate dihydrate deposition disease (CPPD). It is associated with periarticular or intraarticular deposition of hydroxyapatite crystals. Crystal deposition in the joint causes the release of collagenases, serine proteases, elastases, and interleukin-1. This precipitates acute and rapid decline in joint function and degradation of joint anatomy. Subsequently disruption of the rotator cuff ensues. Along with symptomatology, the disease typically presents with positive radiologic findings, often showing marked erosion of the humeral head, cartilage, capsule, and bursae. Though rare, it is most often seen in females beginning in their 50s or 60s. Diagnosis is made with arthrocentesis and Alizarin Red staining along with clinical symptoms. Signs and symptoms may include the following: Limited active range of motion, usually unrestricted passive range of movement (early) ...
Support group for people who have Angiomyolipoma and experience Calcium Pyrophosphate Dihydrate Deposition Disease, created by eHealthMe (http://www.eHealthMe.com). To join the group, do any of these: create a post to introduce yourself, ask a question, or simply follow the group.. submitted on 6 months 1 week ago by eHealthMe.com ...
Osteoarthritis is a common feature, most often affecting the knees, shoulders, hips, and hands. Single or multiple joints may be affected. Hypertrophy of cartilage initially produces radiographic widening of the joint space. The newly synthesized cartilage is abnormally susceptible to fissuring, ulceration, and destruction. Ligamental laxity of joints further contributes to the development of osteoarthritis. Cartilage degrades, the joint space narrows, and subchondral sclerosis and osteophytes develop. Joint examination reveals crepitus and laxity. Joint fluid is noninflammatory. Calcium pyrophosphate dihydrate crystals are found in the cartilage in some cases of acromegaly arthropathy and, when shed into the joint, can elicit attacks of pseudogout. Chondrocalcinosis may be observed on radiographs. Back pain is extremely common, perhaps as a result of spine hypermobility. Spine radiographs show normal or widened intervertebral disk spaces, hypertrophic anterior osteophytes, and ligamental ...
Methods A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD. Afterwards, 19 members of the panel met in Siena, Italy, for the patient-based exercise. During the exercise, all sonographers examined twice eight patients for the presence/absence of CPPD at the same joints. Intraoberserver and interobserver kappa values were calculated for both exercises. ...
Mg is a divalent cation mostly located intracellularly. It plays an important role in enzymatic processes. In healthy individuals homeostasis of Mg is regulated effectively, as sufficient mechanisms in the gastrointestinal tract and the kidney exist. However, if these mechanisms are affected in underlying disease, Mg depletion can cause a wide range of symptoms such as neuromuscular manifestations (muscular cramps, vertigo, tetany), cardiac and vascular manifestations (arrhythmias, hypertension), metabolic sequels and psychiatric manifestations (depression, fatigue) [11, 12].. As seen in this case, severe Mg depletion resulted in CPPD deposition with clinical manifestations of chronic inflammatory arthritis [13-16] and was responsible for muscular weakness, fatigue and the depressive episode.. Chondrocalcinosis, is defined as the deposition of calcium pyrophosphate dihydrate in hyaline or fibrous cartilage [14]. In radiography delicate linear calcification of the cartilage can be seen. The ...
Precipitation of crystals of calcium pyrophosphate dihydrate (CPP) in connective tissues may be asymptomatic or may be associated with several clinical syndromes. These disorders, including acute inflammatory, chronic inflammatory, and degenerative a
Iron was readily demonstrated in chondrocytes in 3 of 4 hemochromatosis articular cartilages studied. Either apatite, calcium pyrophosphate dihydrate crystals, or both were found in all cartilages including those of 3 patients who had no radiographic or light microscopic evidence of calcification. These crystals, which may be secondary to degenerative changes or may play a role in cartilage degeneration, were not seen in any consistent morphologic relationship with the iron deposits. In fact, apatite was found in one cartilage in which no iron was identified in the sections studied. If iron, as demonstrated in the chondrocytes, is contributing to the calcium crystal deposition, it would most likely do so indirectly, for example by altering chondrocyte enzymes or connective tissue components.
Psuedogout, also referred to as calcium pyrophosphate deposition disease, or CPDD, is a form of arthritis caused by crystal deposits in joints. The American College of Rheumatology states there is no...
OBJECTIVE: To evaluate the ability of baseline hand radiographs to predict the diagnosis 2 years later in a cohort of patients with early arthritis. METHODS: A total of 258 patients with arthritis onset within the previous year were evaluated. At baseline, all patients underwent a standardized evaluation including laboratory tests and radiographs. Hand radiographs were read by a blinded observer who used a standardized procedure for detecting features of crystal deposition diseases and rheumatoid arthritis (RA). After 30 +/- 11.3 months, the final diagnosis was established by a panel of rheumatologists. All radiographs were evaluated. RESULTS: Significant associations were found between radiographic features and a clinical diagnosis of RA, calcium pyrophosphate dihydrate (CPPD) arthritis, and hydroxyapatite arthritis. No radiographic abnormalities suggesting psoriatic arthritis or gout were seen. The sensitivities of hand radiographs for diagnosing CPPD or hydroxyapatite arthritis ranged from ...
Rheumatoid Arthritis is an auto-immune disease in which our immune system mistakenly attacks healthy joint tissue. It causes swelling, pain and eventually joint deformities. The inflammation can spread to the surrounding tissues and damage cartilage and bones. About 21 million people are affected by this disease globally each year.. Gout & Calcium Pyrophosphate Deposition Disease (CPPD) are caused by excess uric acid and calcium salt respectively, forming crystals in joints and causing inflammation, redness and swelling. Causes are unclear, but the risk increases with age and the disease is often misdiagnosed as arthritis. ...
The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues, lung, and the peritoneum. The mitogenic activity of basic calcium phosphate (BCP) crystals and calcium pyrophosphate dihydrate (CPPD) crystals on synovial fibroblasts has been considered relevant to the synovial hyperplasia observed in crystal-induced arthritis. The aim of the study was to determine whether microcrystals such as these could enhance macrophage survival and induce DNA synthesis, thus indicating that they may contribute to the tissue hyperplasia. Murine bone-marrow-derived macrophages were treated in vitro with microcrystals, the cell numbers were monitored over time, and DNA synthesis was measured as the incorporation of [methyl-3H]thymidine (TdR). We report here that BCP, monosodium urate, talc, and, to a lesser extent, CPPD crystals promote macrophage survival and DNA synthesis; the latter response is particularly striking
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Many crystals have been associated with arthropathies or periarticular syndromes: only monosodium urate monohydrate (gout), calcium pyrophosphate dehydrate (pseudogout, chondrocalcinosis), and basic calcium phosphates (mainly hydroxyapatite) are common.Crystals implicated in joint disease are stable, hard particles that exert biological effects via surface-active (activation of humoral and cell-derived mediators, interaction with cell membranes) and mechanical properties. In general, smaller particle size, marked surface irregularity, and high negative surface charge correlate with inflammatory potential....
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Calcium Pyrophosphate Arthritis - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.
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Definition It is a crystal deposition of calcium pyrophosphate dehydrate (CPPD) in cartilage (chondrocalcinosis). It is a common age associated phenomenon (|55) that particularly targets the knee . Aetiology (Causes)
If the skin over the joint is hot and red, and the pain comes in repeated attacks, the cause is likely to be either gout or pseudogout.. Both of these are types of arthritis. Gout usually affects the joint of the big toe first before affecting other joints. Its important to correctly diagnose gout, as treatment will prevent future attacks of joint pain and disability.. Pseudogout is similar to gout, but usually affects the knee joint first.. See your GP if you think you have gout or pseudogout.. ...
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Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage
Background. There are few data on anakinra use after failure of conventional medications for crystal-induced peripheral arthritis and/or crowned dens syndrome among complex hospitalized patients. Methods. We retrospectively analyzed the outcome of six patients affected with subacute crystal-induced arthritis who had received anakinra in second or third line therapy, including three patients with crowned dens syndrome and three others with gouty arthritis. Patients comorbidities, reasons for anakinra use and associated drugs, and outcomes were recorded. Results. All patients presented with elevated inflammatory syndrome, systemic symptoms with poly/oligoarthritis. Except for absolute contraindications, all patients were previously treated with full or decreased dose of NSAID, colchicine, and/or glucocorticoids, with unsatisfactory response. All three gouty patients exhibited complete responses in all acute involvements under anakinra within 3 to 5 days, including one of them who needed the
We analysed the histological findings in 1146 osteoarthritic femoral heads which would have been considered suitable for bone-bank donation to determine whether pathological lesions, other than osteoarthritis, were present. We found that 91 femoral heads (8%) showed evidence of disease. The most common conditions noted were chondrocalcinosis (63 cases), avascular necrosis (13), osteomas (6) and malignant tumours (one case of low-grade chondrosarcoma and two of well-differentiated lymphocytic lymphoma). There were two with metabolic bone disease (Pagets disease and hyperparathyroid bone disease) and four with inflammatory (rheumatoid-like) arthritis. Our findings indicate that occult pathological conditions are common and it is recommended that histological examination of this regularly used source of bone allograft should be included as part of the screening protocol for bone-bank collection.
The deposit of uric crystals is one of the complications that you can have when suffering from gout. These tophi get formed in the joints of your hands and feet. This gout complication usually causes deformities, damage the tissue that surrounds the area of the gout. As a result you might suffer from destruction of your joint, constant pain and more worse, compression of your nerves. This is just one of the many gout effects. It takes about ten years for a gout patient to develop a chronic gout stage. At this stage, the gout has already cause serious damage to your joints. Of course, we are talking about the joints that have been affected by the gout. Furthermore, at this stage, some damage to your kidneys may have also been cause by the gout. More than half of the gout patients that have reached this stage also suffer from tophi, which are crystals of uric acid. Studies show that a number of three gout patient out of four suffer from tophi by the time they have reached the twentieth year of ...
Heritage, Hippocrates has been basically one among the very first customer to try to define or explain precisely what instigated gout. Its recognized that back within the 400 B.C. Hippocrates reasoned that gout had been connected for the four humors in your body. They belief that in case every one of the four humors were absolutely suppose for being balanced healthy to create good wellness and also in case it had become unbalanced after that that delivered disease for the body system. The 4 Humours have been nothing yet the blood, phlegm, the yellow bile and the african american bile. He thought that main motive of Gout was the excessive of one of these four humors. He believed that if you experience the surplus of this and in case put towards the joint elements this may cause undesired soreness and also bloating or irritation ...
If the skin over the joint is hot and red, and the pain comes in repeated attacks, the cause is likely to be either gout or pseudogout.. Both conditions are types of arthritis. Gout usually affects the joint of the big toe first, before affecting other joints. Its important to correctly diagnose gout, as treatment will prevent future attacks of joint pain and disability.. Pseudogout is a similar condition to gout, but usually affects the knee joint first.. See your GP if you think you have either condition.. ...
hi doctor. Ive been getting a lot of pain in my feet and my girlfriend thinks it is gout. what should I do to treat it? also, I know that there are dietary changes to be made, but I eat healthy foo...
There are two main types of gout, primary and secondary. Most (90%) of gout sufferers fall into the primary category. This is a pattern with a cause that is generally unknown (idiopathic), although there are some genetic patterns that can lead one to tend toward elevated uric acid. Secondary gout is identified when uric acid is elevated in response to some other disorder (such as kidney disease). Some medicines (such as aspirin and diuretics) can lead to the onset of gout attacks because they decrease the excretion of uric acid from the body ...
Like you, I become interested in medical astrology from time to time on an as needs basis. Unless you are a full-time astrologer, the strict rules of decumbiture provide examples only occasionally. I tend to rely on times provided by friends of mine having a medical crisis. This isnt a very systematic way of studying decumbiture, but over the past few months several of my close friends have experienced illnesses resulting in need for bed rest, ER visits, etc. So I will try to get a few more permissions to post decumbiture charts from these folks for discussion here ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Deposition diseases related fibromyalgia information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
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Fluid accumulated in the knee of a patient causes pain in the joints. Joint aspiration is a procedure that is conducted to remove this fluid from the knee of the patient. It is usually conducted in patients suffering from arthritis.
Joint aspiration is a procedure to remove fluid from the space around a joint using a needle and syringe. It may be done to relieve swelling and/or to obtain fluid for analysis to diagnose a joint disorder and/or problem.
Care guide for Joint Aspiration. Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
AA (Inflammatory) AmyloidosisDiabetic NephropathyFamilial Renal AmyloidosisIgA NephropathyImmunoglobulin-Related AmyloidosisLight Chain-Associated Renal DisordersMultiple MyelomaNephrotic Syndrome
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Building on our extraordinary leadership in pediatric science at Boston Childrens, we translate our findings - and those of others - to fundamentally change how disease is treated and cured ...
LIPA Chondrocalcinosis 2; 118600; ANKH Chondrodysplasia punctata, rhizomelic, type 2; 222765; GNPAT Chondrodysplasia punctata, ...
"ATP-induced chondrocalcinosis". Arthritis Rheum. 35 (12): 1520-5. doi:10.1002/art.1780351216. PMID 1472129. Heptad Repeat 2 in ...
1996). "Localisation of a gene for chondrocalcinosis to chromosome 5p". Hum. Mol. Genet. 4 (7): 1225-8. doi:10.1093/hmg/4.7. ... 2002). "Mutations in ANKH cause chondrocalcinosis". Am. J. Hum. Genet. 71 (4): 933-40. doi:10.1086/343054. PMC 378546. PMID ... 2000). "Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome ...
Haemochromatosis arthropathy includes degenerative osteoarthritis and chondrocalcinosis. The distribution of the arthropathy is ...
Using ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage or ... X-ray, CT, or other imaging usually shows accumulation of calcium within the joint cartilage, known as chondrocalcinosis. There ... Previous studies have overestimated the prevalence by simply estimating the prevalence of chondrocalcinosis, which is found in ... Free chapter on acromioclavicular chondrocalcinosis is available at ShoulderUS.com Hosler, Greg. "calcinosis_cutis_2_060122". ...
December 1999). "Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at ...
... chondrocalcinosis). Infrequent ADRs include: dyslipidemia, increased serum creatinine concentration, hypocalcemia, rash. ...
This is used to assess any problems in the surrounding structures such as bone fractures, chondrocalcinosis, and inflammatory ...
... chondrocalcinosis, features of pyrophosphate arthropathy, and calcific periarthritis. Odontohypophosphatasia is present when ...
... storage disease Cholesterol esterification disorder Cholesterol pneumonia Chondroblastoma Chondrocalcinosis Chondrocalcinosis ...
... chondrocalcinosis MeSH C05.550.114.423 - gout MeSH C05.550.114.423.410 - arthritis, gouty MeSH C05.550.114.606 - osteoarthritis ...
... chondrocalcinosis, or weakness expressed as extreme fatigue or irritability. Though cravings for salt are most common and ...
711 Arthropathy associated with infections 712 Crystal arthropathies 712.1 Chondrocalcinosis due to dicalcium phosphate ... crystals 712.2 Chondrocalcinosis due to pyrophosphate crystals 712.3 Chondrocalcinosis, cause unspecified pseudogout 712.8 ...
... chondrocalcinosis and arthropathy due to amyloidosis. RS3PE has been documented in patients with cancers (Non-Hodgkin's ...
Chondrocalcinosis (pseudogout) Mirgh, S. P.; Venkatesh, M. P. (2017). "Lumps All over: A Case of Chronic Tophaceous Gout ( ...
... chondrocalcinosis, spasticity and tetany, migraines, epileptic seizures, basal ganglia calcifications and in extreme and ...
X-rays will also show bone features of renal osteodystrophy (subperiostic bone resorption, chondrocalcinosis at the knees and ...
In some cases, arthritis from injury can cause chondrocalcinosis. Other causes of chondrocalcinosis include: Hypercalcaemia, ... At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage. As ... Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline cartilage and/or ... "Chondrocalcinosis". Radiopedia. Retrieved 2017-08-11. Ann K. Rosenthal. "Clinical manifestations and diagnosis of calcium ...
In pseudogout/chondrocalcinosis/calcium pyrophosphate deposition disease, the crystal is calcium pyrophosphate. Diabetic ... Felty's syndrome Juvenile idiopathic arthritis Adult-onset Still's disease Crystal arthropathy Gout Chondrocalcinosis ...
Metabolic disease (gout, chondrocalcinosis). *Capsulitis, synovitis. *Ankylosis (fibrous or bony). *Fracture. *Absent, large, ...
In some cases, arthritis from injury can cause chondrocalcinosis. Other causes of chondrocalcinosis include: Hypercalcaemia, ... At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage. As ... Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline cartilage and/or ... "Chondrocalcinosis". Radiopedia. Retrieved 2017-08-11. Ann K. Rosenthal. "Clinical manifestations and diagnosis of calcium ...
Chondrocalcinosis. It may be necessary to differentiate between patients with a generalized chondrocalcinosis with synovitis ...
MRI described chondrocalcinosis in 2 of 2 wrists but not in either the elbows and knees. The study authors observed that ... The Use of Ultrasound to Screen for Chondrocalcinosis. Thiele and Schlesinger[29] explored the use of ultrasound to detect CPPD ... Conventional radiography detected chondrocalcinosis in 7 out of the 8 knees and 2 out of 2 elbows and wrists. ... MRI was not useful in detecting chondrocalcinosis in either the elbows or the knees, in agreement with past findings. Because ...
Chondrocalcinosis. Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline ... Idiopathic chondrocalcinosis. Posttraumatic osteoarthritis. Uncommon. Acromegaly. Alkaptonuria. Chronic pyarthrosis. Gout. ...
Chondrocalcinosis. Chondrocalcinosis is calcification of the menisci, synovium, and/or articular cartilage due to the ... Effect of chondrocalcinosis on the MR imaging of knee menisci. AJR Am J Roentgenol. 2001 Oct. 177(4):905-9. [QxMD MEDLINE Link] ... Chondrocalcinosis mimicking a meniscal tear on MR imaging. AJR Am J Roentgenol. 1998 Jan. 170(1):69-70. [QxMD MEDLINE Link]. ... The presence of chondrocalcinosis can result in a false-positive diagnosis of a meniscal tear. View Media Gallery ...
... Home/Localized Chondrocalcinosis of the Lateral Tibial Condyle ... Localized Chondrocalcinosis of the Lateral Tibial Condyle JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY 1992. Chondrocalcinosis, ... Localized Chondrocalcinosis of the Lateral Tibial Condyle Idiopathic Osteonecrosis of the Patella: An Unusual Cause of Pain in ... chondrocalcinosis can occur in young athletes, possibly after repetitive microtrauma, and should be included in the ...
The following pages link to Chondrocalcinosis: Displayed 6 items. View (previous 50 , next 50) (20 , 50 , 100 , 250 , 500) ...
Although CPDD is often asymptomatic, with only radiographic changes seen (ie, chondrocalcinosis), various clinical ... Saffar P. Chondrocalcinosis of the wrist. J Hand Surg [Br]. 2004 Oct. 29(5):486-93. [QxMD MEDLINE Link]. ... The prevalence of chondrocalcinosis of the symphysis pubis on CT scan and correlation with calcium pyrophosphate dihydrate ... In a study of patients with familial osteoarthritis with chondrocalcinosis, Ramos et al identified a mutation in TNFRSF11B that ...
PubMed is a searchable database of medical literature and lists journal articles that discuss Chondrocalcinosis 1. Click on the ...
PubMed is a searchable database of medical literature and lists journal articles that discuss Chondrocalcinosis 1. Click on the ...
Chondrocalcinosis (symphysis) , 580 , 616 , 651 Chondrocalcinosis (left) , 581 , 617 , 652 Head deformity (primary/secondary ... ITEM DESCRIPTION & CODES Counts HANES I Data Source 503 Chondrocalcinosis - Left Data from X-Ray 0 - Normal 6678 Readings 1 - ... ITEM DESCRIPTION & CODES Counts HANES I Data Source 524 Chondrocalcinosis - Right Data from X-Ray 0 - Normal 6670 Readings 1 - ... ITEM DESCRIPTION & CODES Counts HANES I Data Source 581 Chondrocalcinosis - Left 0 - Normal 4691 Data From X-Ray 1 - ...
Chondrocalcinosis. *Chronic Fatigue Syndrome. *Chronic Neck Pain. *Chronic Pain. *Cutaneous Lupus Erythematosus ...
Chondrocalcinosis is also commonly seen on the X-rays of individuals with CPPD. In spite of this fact, however, the presence of ... Chondrocalcinosis People who undergo chronic bouts of CPPD may eventually experience physical changes within their affected ... This finding is often thought of as a precursor to arthritis, though chondrocalcinosis itself does not always cause joint pain ... This process, called chondrocalcinosis, refers to the hardening or calcification of the smooth cartilage tissue. ...
Chondrocalcinosis and osteoarthropathy may develop with age (Figure 4). Osteomalacia distinguishes adult hypophosphatasia from ...
Chondrocalcinosis. *Chronic Neck Pain. *Chronic Pelvic Pain. *Clavicle Fracture. *Complex Regional Pain Syndrome (CRPS) ...
Chondrocalcinosis / chemically induced * Chondrocalcinosis / metabolism * Chondrocalcinosis / pathology * Colchicine / ...
Hypercalcemia occurs when calcium levels in the blood become elevated. Almost 90% of all cases are caused by primary hyperparathyroidism (HPT) or hypercalcemia of malignancy. Symptoms are nonspecific and can include depression, confusion, difficulties in concentrating, hypertension, constipation, nausea, fatigue, and/or muscle weakness. Patients with chronically elevated calcium levels may have few to no symptoms whereas patients with a sudden acute elevation may experience dramatic changes in their mental status. Parathyroid surgery is the most effective treatment option for HPT. In other cases, treatment depends on the cause.
Disabling polyarthropathy or chondrocalcinosis. *. Major low trauma fracture attributable to hypophosphatasia (eg, spine, hip, ...
Chondrocalcinosis, osteoarthritis, metabolic bone disease, juvenile polyarthritis, recurrent fracture and dislocation. ...
206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 description 10 * 206010018634 Gouty arthritis Diseases 0.000 ... 208000002849 Chondrocalcinosis Diseases 0.000 description 17 * 238000004128 high performance liquid chromatography Methods ...
Jensen PS: Chondrocalcinosis and other calcifications. Radiol Clin North Am 1988 Nov;26(6):1315-25. [See related articles] Van ... Pritchard MH, Jessop JD: Chondrocalcinosis in primary hyperparathyroidism. Influence of age, metabolic bone disease, and ... Calcification of articular (hyaline) cartilage (chondrocalcinosis). Bilateral symmetrical sacroilitis. Causes of erosive ...
Chondrocalcinosis (crystal deposition disease): 153 reports. *Chondromalacia (anterior knee pain due to irritation of the ...
11 Wilkins E, Dieppe P, Maddison P, Edison G. Osteoarthritis and articular chondrocalcinosis in the elderly. Ann Rheum Dis. ...
Investigating ANKH and ENPP1 in Slovakian families with chondrocalcinosis. Rheumatology International, 32(9), 2745 - 2751.* ...
Foldes K, Lenchik L, Jaovisidha S, et al: Association of gastrocnemius tendon calcification with chondrocalcinosis of the knee ...
  • Radiograph of the wrist and hand showing chondrocalcinosis of the articular disc of the wrist and atypical osteoarthritis involving the metacarpophalangeal joints in a patient with underlying hemochromatosis. (medscape.com)
  • In a study of patients with familial osteoarthritis with chondrocalcinosis, Ramos et al identified a mutation in TNFRSF11B that results in a form of osteoprotegerin with enhanced capacity to inhibit osteoclastogenesis and bone resorption. (medscape.com)
  • Age at presentation, body mass index, symptom duration, or presence of chondrocalcinosis, hand osteoarthritis/nodes, or Forestier's disease did not influence progression. (bmj.com)
  • The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case-control study. (cdc.gov)
  • Other causes of chondrocalcinosis include: Hypercalcaemia, especially when caused by hyperparathyroidism Arthritis Pseudogout Wilson disease Hemochromatosis Ochronosis Hypophosphatasia Hypothyroidism Hyperoxalemia Acromegaly Gitelman syndrome Chondrocalcinosis can be visualized on projectional radiography, CT scan, MRI, US, and nuclear medicine. (wikipedia.org)
  • Other crystal arthritis are calcium pyrophosphate arthropathy (chondrocalcinosis or pseudogout) and hydroxyapatite arthropathy, in which the deposits are due to calcium salts. (gsdinternational.com)
  • In some cases, arthritis from injury can cause chondrocalcinosis. (wikipedia.org)
  • Colchicine has proved its efficiency in the treatment of chondrocalcinosis, gouty acute arthritis and Behcet's disease. (canadianpharmacy365.net)
  • The clinical features of symptomatic Hemochromatosis include liver cirrhosis that might progress into hepatocellular carcinoma, diabetes mellitus from pancreatic islet iron deposition, skin pigmentation, hypogonadotropic hypogonadism, arthritis from chondrocalcinosis and synovial hemosiderosis, cardimyopathy, and arrhythmias. (hpathy.com)
  • His top areas of expertise are Calcium Pyrophosphate Arthritis, Chondrocalcinosis 2, Arthritis, and Gout. (medifind.com)
  • Arthropathies with calcium crystal deposition cause calcification of periarthritic tissues (calcified periarthritis), calcium deposition in articular cartilage (chondrocalcinosis) and acute arthritis (pseudopodagra). (gsdinternational.com)
  • Another common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD). (wikipedia.org)
  • Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline cartilage and/or fibrocartilage. (wikipedia.org)
  • This process, called chondrocalcinosis , refers to the hardening or calcification of the smooth cartilage tissue. (verywellhealth.com)
  • The deficiency predisposes you to a condition known as chondrocalcinosis, or painful calcium deposits in the hyaline cartilage in your joints. (chiropractic-help.com)
  • Previous studies have overestimated the prevalence by simply estimating the prevalence of chondrocalcinosis regardless of cause. (wikipedia.org)
  • Awareness of this potential pitfall and an understanding of the characteristic appearance and location of this collection of intra-articular gas may help prevent misdiagnosis of intra-articular loose bodies or chondrocalcinosis . (pacs.de)
  • At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage. (wikipedia.org)
  • Affected individuals are usually asymptomatic, but may present chondrocalcinosis and pancreatitis. (renaltube.com)
  • Completely asymptomatic patients may only have chondrocalcinosis in adulthood. (preventiongenetics.com)
  • Chondrocalcinosis in primary hyperparathyroidism. (gentili.net)
  • 2012). Investigating ANKH and ENPP1 in Slovakian families with chondrocalcinosis . (up.pt)
  • Patients with Wilson disease may present with polyarthritis, osteochondritis dissecans, chondromalacia patellae, or chondrocalcinosis. (rarediseaseadvisor.com)
  • As with most conditions, chondrocalcinosis can present with similarity to other diseases such as ankylosing spondylitis and gout. (wikipedia.org)
  • Chondrocalcinosis, although very rare in young adults, can occur in some young patients. (drrobertlaprademd.com)
  • Although its presenting clinical history or radiographic findings may resemble those of an intraarticular loose body, chondrocalcinosis can occur in young athletes, possibly after repetitive microtrauma, and should be included in the differential diagnosis of calcified intraarticular lesions in the young athlete. (drrobertlaprademd.com)
  • A magnesium deficiency may cause chondrocalcinosis, and there is anecdotal evidence that magnesium supplementation may reduce or alleviate symptoms. (wikipedia.org)
  • The diagnostic performance of MR imaging in the detection of meniscal tears has been shown to decrease in the presence of chondrocalcinosis (16). (cisplatin.info)
  • [ 11 ] Nearly 50% of people older than 85 years have radiologic evidence of chondrocalcinosis. (medscape.com)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Chondrocalcinosis 1. (rareendocrinologynews.com)
  • Ultrasonographic study of Achilles tendon and plantar fascia in chondrocalcinosis. (qxmd.com)
  • These symptoms are very similar to gout so when chondrocalcinosis takes on this form it is often referred to as pseudogout. (facty.com)
  • A type of arthritis that is called pseudogout ('false gout '), or chondrocalcinosis, can cause fine calcium deposits on the cartilage of the knees and other joints. (everydayhealth.com)
  • This week it's the great and not-so-great on gout, chondrocalcinosis, osteoporosis and misdiagnosis. (rheumnow.com)
  • Radiographic chondrocalcinosis (27%) and documented pyrophosphate arthropathy (14%) were only observed in women. (qxmd.com)
  • Adult hypophosphatasia with chondrocalcinosis and arthropathy. (qxmd.com)
  • Metabolic disease affecting the joints (gouty arthritis, articular chondrocalcinosis, ochronotic arthropathy etc. (hotels-spa.eu)
  • We compared the frequency of arthralgia, and the presence of chondrocalcinosis, osteophytes, joint space narrowing and radiographic osteoarthritis in hand, hip and knee joints, and Heberden's nodes in carriers of HFE variants with that in non-carriers. (ox.ac.uk)
  • CONCLUSIONS: The HFE H63D variant may explain, at least in part, the prevalence of arthralgia in multiple joints sites, chondrocalcinosis, and hand osteoarthritis in the general population. (ox.ac.uk)
  • The anomaly concerns a protein expressed in joints and other tissues and its consequence, ie the alteration of PPi levels, leads to chondrocalcinosis. (dantelabs.com)
  • Chondrocalcinosis and other calcifications. (gentili.net)
  • The resulting calcifications, which doctors call chondrocalcinosis, show up on x-rays. (arthritis-health.com)
  • Hence, more investigation considering to the diagnosis of chondrocalcinosis among patients with OA is very important. (advbiores.net)
  • These results suggest that adult HPP demonstrates a wide spectrum of clinical manifestations including musculoskeletal pain, fractures, chondrocalcinosis and dental anomalies with some overlap in laboratory characteristics in relationship to disease severity. (qxmd.com)
  • Chondrocalcinosis in primary hyperparathyroidism. (gentili.net)
  • Although benign in most cases, CaSR mutations can cause muscle cramps, kidney stones, chondrocalcinosis and seizures in some patients. (endocrinology.org)
  • About 25 percent of all chondrocalcinosis patients will develop pseudogout. (facty.com)
  • Only about 5 percent of patients with chondrocalcinosis. (facty.com)
  • The patients images were studied for chondrocalcinosis and OA by a radiologist and also examined clinically and results of imaging by an expert rheumatologist. (advbiores.net)
  • X-ray findings of chondrocalcinosis are frequently seen in these patients. (columbusarthritis.com)
  • Symptomatic subjects had more fractures and chondrocalcinosis, lower median minimum AP and PLP and higher median PEA levels. (qxmd.com)
  • Type 2 chondrocalcinosis, rare and also with autosomal dominant inheritance, is caused by the deposition of crystals in the vertebral area. (dantelabs.com)
  • Chondrocalcinosis is present in over 20 percent of all people at age 80 years or older, but most show no symptoms. (facty.com)
  • It is possible to have chondrocalcinosis or joint damage without having pseudogout, so x-rays should not be the sole diagnostic tool used. (arthritis-health.com)
  • If your doctor suspects chondrocalcinosis he or she will likely order either a joint fluid examination or X-rays to determine if you have chondrocalcinosis. (facty.com)