A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)
A scraping, usually of the interior of a cavity or tract, for removal of new growth or other abnormal tissue, or to obtain material for tissue diagnosis. It is performed with a curet (curette), a spoon-shaped instrument designed for that purpose. (From Stedman, 25th ed & Dorland, 27th ed)
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Tumors or cancer located in bone tissue or specific BONES.
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
Neoplasms of the bony part of the skull.
Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Fractures of the proximal humerus, including the head, anatomic and surgical necks, and tuberosities.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)
A bone fixation technique using an external fixator (FIXATORS, EXTERNAL) for lengthening limbs, correcting pseudarthroses and other deformities, and assisting the healing of otherwise hopeless traumatic or pathological fractures and infections, such as chronic osteomyelitis. The method was devised by the Russian orthopedic surgeon Gavriil Abramovich Ilizarov (1921-1992). (From Bull Hosp Jt Dis 1992 Summer;52(1):1)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
The bones of the free part of the upper extremity including the HUMERUS; RADIUS; and ULNA.
A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).

Chondroblastoma of the temporal bone: a clinicopathologic study of five cases. (1/41)

Chondroblastoma is a rare benign bone tumor. It commonly affects the epiphysis of long bones during the second and third decades of life. Chondroblastoma of the temporal bone is extremely rare. We reviewed five cases of chondroblastoma arising in the temporal bone. Four cases were female and one was male. The ages ranged from 41 to 60 years (mean, 53.6 years). All cases involved the temporal bone. Three involved the left side and two the right. Chief complaints were long-standing localized pain and hearing difficulty. A sharply demarcated lobulated mass was the main radiological finding. Microscopic findings were those of chondroblastoma of usual locations. Two cases showed aneurysmal bone cyst-like areas. Immunohistochemical studies for CD34, CD99, S-100 protein and cytokeratin were performed. Tumor cells were diffusely positive for S-100 protein in three cases and weakly positive for cytokeratin in one case. CD34 and CD99 were negative in all cases. In summary, chondroblastoma of the temporal bone is rare and occurs in older age group than reported cases of chondroblastoma of the usual location in the literature.  (+info)

Extendible replacements of the proximal tibia for bone tumours. (2/41)

Limb salvage is now customary in the treatment of primary bone tumours. The proximal tibia is a frequent site for these neoplasms but reconstruction, especially in children, is a formidable challenge. We reviewed 20 children with extendible replacements of the proximal tibia, all with a minimum follow-up of five years. Five died from their disease and, of the remaining 15, four had above-knee amputations for complications. Infection occurred in seven patients; in five it was related to the lengthening procedure. Aseptic loosening is inevitable in the younger children and only two have avoided a revision, amputation or other major complication; both were aged 12 years at the time of the initial surgery. Despite this, 11 children are alive with a functioning leg and a mean Musculoskeletal Tumour Society functional score of 83%. The lengthening mechanisms used in our series required extensive open operations. We are now using a simpler, minimally invasive, technique which we hope will decrease the incidence of complications. At present, the use of extendible prostheses of the proximal tibia remains an experimental procedure.  (+info)

h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. (3/41)

Caldesmon is a protein widely distributed in smooth and non-smooth muscle cells and is thought to regulate cellular contraction. Its isoform, high-molecular-weight caldesmon (h-CD), was demonstrated to be specific for smooth muscle cells and smooth muscle tumors of the soft tissue and to never be expressed in myofibroblasts. We performed an immunohistochemical study to examine h-CD expression in the following bone tumors: conventional and non-conventional osteosarcoma, 13; malignant fibrous histiocytoma of bone, 5; giant cell tumors of bone, 5; chondroblastoma, 3; metastatic leiomyosarcoma, 2; and rhabdomyosarcoma, 1. Frequent immunoreactivity for muscle actin (alpha-smooth muscle actin or muscle-specific actin) was seen in 11 of 13 osteosarcomas and all other tumors, whereas h-CD was expressed intensely only in 2 leiomyosarcomas. h-CD is considered a specific and useful marker to distinguish smooth muscle tumor from bone tumors with myoid differentiation.  (+info)

Benign chondroblastoma of bone. Report of a case. (4/41)

A benign chondroblastoma of bone is reported. It was unusual because it occurred in an old lady, in a toe, and it was not painful and radiologically resembled a chondroma. The coarsely lobulated tumour showed a varied microscopic appearance, but it consisted chiefly of closely packed sheets of small, round polygonal or fusiform cells. There was some calcification present. The literature is reviewed.  (+info)

Chondroblastoma of a metacarpal bone mimicking an aneurysmal bone cyst: a case report and a review of the literature. (5/41)

Chondroblastoma of the metacarpal bone has been extremely rare and only seven cases have been reported in the English literature. Here we reported the eighth case of a chondroblastoma that developed on the first metacarpal bone of the right hand of a 21-year-old man. Radiographs showed an expansile osteolytic lesion with a multilocular appearance. In MR images, the lesion showed low intensity in T1 and high intensity in T2-weighted images with multiple fluid-fluid levels, which are findings resembling those of an aneurysmal bone cyst. From the pathological findings, however, it was recognized as a chondroblastoma with aneurysmal bone cyst-like change. Good clinical results was obtained by the subtotal resection of the metacarpal bone with a columnar-shaped iliac bone graft.  (+info)

Coexisting chondroblastoma and osteochondroma: a case report. (6/41)

The coexistence of two different types of benign cartilaginous tumours of bone in the same patient has not been reported in literature. We report a case in which a sixteen-year-old male had a benign chondroblastoma of the proximal left humerus and an osteochondroma of the distal left femur. Both originated at the same time and had a progressive increase in size with growth.  (+info)

Chondroblastoma of the temporal base with high mitotic activity. (7/41)

A 24-year-old man presented with a rare chondroblastoma of the temporal base manifesting as local pain accompanied by difficulty in opening the mouth. Gross total removal was achieved at initial surgery, but the tumor demonstrated rapid and destructive regrowth from a very small residual volume without definite histological malignant transformation. Growth activity estimated by MIB-1 staining increased spontaneously from 2.5% at the initial operation to 18.7% at recurrence. Further extensive radical tumor removal by surgeons from multiple disciplines was performed. The patient has been free of recurrence for 3 years without radiotherapy. Chondroblastoma of the temporal bone is widely accepted as a benign tumor and regrowth after gross total removal is very rare. However, some cases of chondroblastoma have potentially high mitotic activity.  (+info)

Skull base chondroblastoma: a case report. (8/41)

Chondroblastoma is a rare tumor of the skull. Temporal bone is the commonest site of involvement in the skull. We present a thirty one year old man who presented with painless swelling over the left temporal bone, which was near totally excised after preoperative embolization. Management of this unusual tumor and its complications are discussed.  (+info)

cellular. + 381 64 1924274. Abstract. Chondroblastoma is a rare, usually benign, tumour and represent 1% of primary bone tumours. Skull base chondroblastomas are extremely rare, most frequently located in the squamous part of the temporal bone, as reviewed in the literature. The authors report the first case of chondroblastoma ethmoid-spheno-petro-clival associated with epidural abcces that was treated through curretage of the lesion, and drainage of the abccess and antibiotic treatment. The transmaxillar approach is performed: Lefort one and sagittal maxillar osteotomy. Result of intervention was exelent and no complications trancurred. Key words. spheno-petro-clival chondroblastoma, transfacial approach, curettage. References. ...
Chondroblastoma is a rare tumor, representing only 1-3% of all primary bone tumors, with local pain and swelling lasting for several months as the most important symptoms. It is usually seen as a lytic lesion involving the epiphysis with a thin border of sclerosis and central punctuate calcification in half of the cases in radiographs. It usually causes expansion or enlargement in the affected site. Primary patella lesions are categorized into benign and malignant tumors and metabolic disorders. Giant cell tumor is the most likely differential diagnoses with tumors of the patella. Patella is a relative uncommon site for chondroblastoma.Most of cases of chondroblastoma in patella reported in literature are treated with patellectomy.We treated a large chondroblastic lesion in patella of an 22 year old male with curettage, burring and bone graft and the result was satisfactory after 8 months postoperation,with complete consolidation of new bone on radiographs, absence of pain and full range of knee ...
Sometimes called Codmans tumor, a chondroblastoma is a rare type of benign (noncancerous) bone tumor that originates from cartilage. Cartilage is the specialized, gristly connective tissue and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee.. Chondroblastoma is a rare type of bone tumor that can affect people of all ages. It is, however, most common in children and young adults. This type of tumor is also more common in males than females.. ...
Sometimes called Codmans tumor, a chondroblastoma is a rare type of benign (noncancerous) bone tumor that originates from cartilage. Cartilage is the specialized, gristly connective tissue and the tissue from which most bones develop. Cartilage plays an important role in the growth process. There are many different types of cartilage that are present throughout the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee.. Chondroblastoma is a rare type of bone tumor that can affect people of all ages. It is, however, most common in children and young adults. This type of tumor is also more common in males than females.. ...
A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee. It is also called Codmans tumor. Chondroblastoma can affect people of all ages. But, its most common in children and young adults. Its also more common in males than females. ...
Semantic Scholar extracted view of [a Case of a Benign Chondroblastoma of Bone with a Rare Localization]. by K CHOKANOV et al.
Diagnosis of benign chondroblastoma (costs for program #275514) ✔ Charite University Hospital Berlin ✔ Department of Musculoskeletal Surgery ✔ BookingHealth.com
Diagnosis of benign chondroblastoma (costs for program #219337) ✔ Academic Hospital Cologne-Holweide ✔ Department of Internal Medicine and Gastroenterology ✔ BookingHealth.com
Discussion. Chondroblastomas are rare representing less than 1% of all benign bone tumours1-16 but one author did have the incidence at 5%, possibly only including paediatric bone tumours.17 They arise in the epiphyseal areas of long bones as well as in the apophyses.2-5,7,9-21 Some then extend into the metaphysis.2,3,13,21,22 They occur in the second decade -95% of cases between 5 and 25 years of age.2,6,8,9,11,12,15,21 They appear in males with a ratio of 2-3:1.1,4-11,15-18. They occur mostly in the proximal tibia,7 proximal humerus and proximal femur13,15 as well as in flat bones (34%).3 Seventy-two per cent are found in the lower extremity - 50% around the knee9,19 and 33% in the femur.4 Twenty per cent are found in the humerus9 - 90% of which are in the proximal humerus.4,7 Ten per cent are also found in the small bones of the hands and feet.19 It is the most common tumour of the patella.19 Some say the most frequent site is the proximal humerus.6,11 Some also describe the upper end of the ...
A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee. It is also called Codmans tumor....more ...
A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee. It is also called Codmans tumor....more ...
A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body. Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee. It is also called Codmans tumor....more ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Behjati Sam, , Tarpey Patrick Campbell Peter, J., Presneau, Nadège, Pillay Nischalan, , Van Loo Peter Hassan A Bassim, , Wedge David C., , Cooke, S.L., Gundem, G., Davies, H., Nik-Zainal, S., Martin, S., McLaren, S., Goody, V., Robinson, B., Butler, A., Teague, J.W., Halai, D., Khatri, B., Myklebost, O., Baumhoer Daniel, , Jundt Gernot, , Hamoudi Rifat Wedge David, C., Tirabosco, R., Amary, M.F., Futreal, P.A., Stratton, M.R., Campbell Peter J., , Flanagan, A.M., Scheipl Susanne, and Goodie Victoria, (2013) Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nature Genetics, 45 (12). pp. 1479-1482 ...
TY - JOUR. T1 - Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells. AU - Fernández-Lloris, R.. AU - Viñals, F.. AU - Harley, V.. AU - Ventura, Flaminia. PY - 2003/7/1. Y1 - 2003/7/1. N2 - Chondrogenesis leads to the formation of mature cartilage and generates initial skeletal elements that serve as templates for endochondral bone formation. Bone morphogenetic proteins (BMPs) are involved in several developmental and organogenetic processes and have been identified as key regulators in chondrogenesis. In the present study we sought to determine the transcriptional mechanisms contributing to the induction of chondrogenic markers by BMP-2. Time-course studies with BMP-2-stimulated C3H10T1/2 cells showed a dose-dependent appearance of Alcian-blue-positive material and up-regulated expression of type-II collagen mRNA. This last effect required new protein synthesis because addition of cycloheximide ...
TY - JOUR. T1 - Enchondroma with secondary aneurysmal bone cyst. AU - Bird, Justin E.. AU - Wang, Wei Lien. AU - Deavers, Michael T.. AU - Madewell, John. AU - Lewis, Valerae O.. PY - 2012/11. Y1 - 2012/11. N2 - An enchondroma with complex cystic changes of the proximal femur is described in a 13-year-old male. The case illustrates a unique presentation of an enchondroma and reinforces the importance of considering the presence of secondary aneurysmal bone cysts in both benign and malignant lesions of bone.. AB - An enchondroma with complex cystic changes of the proximal femur is described in a 13-year-old male. The case illustrates a unique presentation of an enchondroma and reinforces the importance of considering the presence of secondary aneurysmal bone cysts in both benign and malignant lesions of bone.. UR - http://www.scopus.com/inward/record.url?scp=84866647767&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84866647767&partnerID=8YFLogxK. U2 - ...
TY - JOUR. T1 - Histone 3.3 Mutations in Giant Cell Tumor and Giant Cell-Rich Sarcomas of Bone.. AU - Righi, Alberto. AU - Mancini, Irene. AU - Gambarotti, Marco. AU - Picci, Piero. AU - Gamberi, Gabriella. AU - Marraccini, Cristina. AU - Tos, Angelo Paolo Dei. AU - Simi, Lisa. AU - Pinzani, Pamela. AU - Franchi, Alessandro. PY - 2017/9. Y1 - 2017/9. N2 - Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas. Sixteen cases of non-metastatic GCTB, 9 GCTB with lung metastases, and 35 giant ...
Tumors originating from the cartilage are classified as chondromas, osteochondromas, chondroblastomas, and chondromyxoid fibromas. Chondromas are subdivided into 2 types: enchondroma and periosteal chondroma7). When chondromas are found distant from the bones, they are referred to as soft tissue chondromas11). Enchondromas tend to grow as expansile patterns, and periosteal chondromas are exophytic9). Spinal chondromas may be derived from hyperplasia of immature spinal cartilage from metaplasia of the connective tissue in contact with the spine or annulus fibrosus8).. Chondromas in the spine constitute about 3% and 4% of all chondromas4,7,9). Cartilage-forming tumors account for 2% of all spinal tumors3). Chondromas are involved in the vertebral structure, vertebral body, neural arch, and spinous and transverse processes. The neural arch is the most common site of lumbar spine chondromas7). A rare spinal intradural chondroma has also been reported4).. Most cervical spine chondromas occur in young ...
Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentation, histopathological features, and additional molecular characteristics of H3.3 mutant osteosarcomas are largely unknown. In this multicentre, retrospective study, a total of 106 conventional high-grade osteosarcomas, across all age groups were re-examined for hotspot mutations in the H3.3 coding genes H3F3A and H3F3B. H3.3 mutant osteosarcomas were re-evaluated in a multidisciplinary manner and analyzed for genome-wide DNA-methylation patterns and DNA copy number aberrations alongside H3.3 wild-type osteosarcomas and H3F3A G34W/L mutant GCTBs. Six osteosarcomas (6/106) carried H3F3A hotspot mutations. No mutations were found in H3F3B. All patients with H3F3A mutant osteosarcoma were older than 30 years with a median age of 65 years. Copy number aberrations that are commonly encountered in high
Clear cell chondrosarcoma is a rare tumor that can be easily confused with benign tumors. The aim of this report is to present a case that is rare, initially diagnosed as aneurysmal bone cyst and then chondroblastoma, and has an interesting extension pattern. A 41-year-old male patient was treated for an apparently benign cystic lesion of the right proximal femur by intralesional excision and bone grafting. The pathological diagnosis was aneurysmal bone cyst. Two years later, the patient presented with a pathological fracture at the same site and a total hip arthroplasty was performed. The pathological specimen was diagnosed as chondroblastoma. Three years later, clinical and radiological examination of the patient revealed a large mass located on the intrapelvic side of the acetabulum. There was no evidence of distant metastases. Both tumors were resected with a wide margin on the femoral side and a marginal margin on the intrapelvic side. The extremity was reconstructed with a resection-type ...
TY - JOUR. T1 - Recurrence of chondromyxoid fibroma of great toe. AU - Mallya, P. Sharan. AU - Sujir, Premjit. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported following surgery. 24 year old male was treated with curettage and bone grafting for chondromyxoid fibroma of great toe 8 years back. 6 years later, he presented with local recurrence of tumour with extensive soft tissue involvement. He was treated with amputation of great toe. After two years follow up, patient was symptom free.. AB - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported ...
Giant cell tumors (GCTs) are common benign bone tumors also known as osteoclastomas. They arise from metaphysis and extends into the epiphysis of the long bones. The lesions usually shows narrow zone of transition, thin cortex, no sclerosis. Differentials include chondroblastoma, aneurysmal bone cyst and enchondroma.. ...
TY - JOUR. T1 - Secondary osteosarcoma. T2 - Is there a predilection for the chondroblastic subtype?. AU - Barker, Jordan P.. AU - Monument, Michael J.. AU - Jones, Kevin B.. AU - Putnam, Angelica R.. AU - Randall, R. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Osteosarcoma is the most common form of primary bone cancer in the adolescent and young adult patient population. Outcomes in patients with secondary osteosarcoma are inferior compared with outcomes in patients with primary osteosarcoma. The goal of this study was to investigate whether there is a predilection for the chondroblastic histologic subtype in secondary osteosarcoma. A retrospective chart review was performed to identify cases of secondary osteosarcoma treated at 1 institution from 1991 to 2012. Histologic subtypes were evaluated by a pathologist, and a review of the literature was also performed to identify the histologic subclassification of additional series of secondary osteosarcomas. Of a total of 131 cases of osteosarcoma, 9 ...
Bone: Chondromyxoid fibroma, Authors: Salvatore Romeo, Pancras CW Hogendoorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
TY - JOUR. T1 - Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. AU - Radig, K.. AU - Hackel, C.. AU - Herting, J.. AU - Oda, Y.. AU - Mittler, U.. AU - Neumann, W.. AU - Roessner, A.. PY - 1997/3/15. Y1 - 1997/3/15. N2 - The development of chemoresistance is one of the major clinical problems in the therapy of malignant bone tumors in childhood. The expression of membrane-bound P-glycoprotein turned out to be an essential factor in the evidence of resistant tumor cells. To investigate the significance of multidrug resistance in the prognosis of highly malignant osteosarcomas, the immunohistologic expression of P-glycoprotein was investigated in the tumor tissue of 52 patients under special consideration of the histologic subtype. The data were compared with the histologic regression grade in the resection specimen and correlated with clinical data. Formalin-fixed, paraffin-embedded tissue and, additionally, fresh frozen material taken ...
Pigmented Villonodular Synovitis Drug market studies the competitive landscape read of the business. The Pigmented Villonodular Synovitis Drug report conjointly includes development plans and policies at the side of producing processes. the foremost regions concerned in Pigmented Villonodular Synovitis Drug Market square measure (United States, EU, China, and Japan).. Get Sample Copy of Report Here: @ www.e-marketresearch.com/request-sample-23250.html. Producers Analysis and prime Sellers of world Pigmented Villonodular Synovitis Drug Market 2019: Bristol-Myers Squibb Co, F. Hoffmann-La Roche Ltd, Novartis AG, Plexxikon Inc. The Pigmented Villonodular Synovitis Drug report will the thorough study of the key business players to grasp their business methods, annual revenue, company profile and their contribution to the world Pigmented Villonodular Synovitis Drug market share. numerous factors of the Pigmented Villonodular Synovitis Drug business just like the offer chain state of affairs, business ...
Pigmented villonodular synovitis (PVNS) is an idiopathic proliferative synovial process composed of two predominant cell types: mononuclear histiocytic cells and giant cells. This lesion can be locally invasive and can result in bone cyst formation and late cartilage and bone loss. Because metalloproteinases have been implicated in the joint destruction occurring in inflammatory arthritis and in the ability of certain tumors to invade adjacent tissues, their presence in PVNS was determined. Synovial tissue samples were collected at surgical synovectomy from the knees of 10 patients with a prior histological diagnosis of PVNS. Pigmented villonodular synovitis synovium was examined for the presence of the metalloproteinases collagenase and stromelysin. Messenger RNA (mRNA) for collagenase and stromelysin was present in all patient samples, although in varying amounts. In situ hybridization studies on synovial tissue sections identified synovial lining cells as the predominant cells expressing these
Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth of the joint lining. It usually affects the hip or knee. It can also occur in the shoulder, ankle, elbow, hand or foot. In PVNS the lining of the joint, called the synovium, becomes swollen and grows. This growth harms the bone next to the joint. The lining also makes extra fluid that can cause swelling and make movement painful. PVNS is idiopathic, it doesnt seem to run in families or be caused by certain jobs or activities. Surgery can help but, even with treatment, PVNS comes back about half the time. If the pain remains then radiation therapy may help. In the worst cases the joint must be replaced. In general, pigmented villonodular synovitis often manifests initially as sudden onset, unexplained joint swelling and pain; the joint swelling is disproportionate to the amount of pain the patient feels at first. Decreased motion and increased pain occur as the disorder progresses as well as ...
Plexxikon, a member of the Daiichi Sankyo Group, announced today promising, proof-of-concept Phase 1 extension clinical data with PLX3397 in pigmented villonodular synovitis (PVNS), a type of rare, often locally aggressive, musculoskeletal neoplasm that arises from the soft tissues of joints and tendons. Interim data from this ongoing trial show that all evaluable patients treated with PLX3397 achieved either partial responses or stable disease. PLX3397 is a novel, oral small molecule that potently and selectively inhibits CSF1R, KIT and oncogenic FLT3 kinases, which play important roles in cancer. CSF1R, in particular, has been shown to be a primary driver in PVNS. These data are being released today as part of the American Society of Clinical Oncology (ASCO) 50th Annual Meeting Press Program. More detailed data will be presented at the ASCO 50th Annual Meeting, being held May 31-June 3 in Chicago.. The data come from an extension cohort of a multicenter Phase 1 clinical study in solid tumors ...
We present a case of pathologically confirmed, relatively rare Pigmented Villonodular Synovitis (PVNS). The patient presented with knee and thigh swelling. While initially misdiagnosed, he eventually underwent an MRI and a biopsy. The MRI was helpful but not definitive. The biopsy confirmed PVNS. The patient underwent synovectomy and was subsequently referred for radiotherapy and physical therapy. Post-treatment MRI showed no evidence of disease.. ...
Pigmented villonodular synovitis (PVNS) is a rare monoarticular proliferative synovial disorder of unknown etiology mostly affecting the knee, foot
HealthTap: Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Krauser on alternative treatments for pigmented villonodular synovitis: Start with oral antiinflammatory medications, such as aleve (naproxen) or advil. A steroid taper would be the next step, or an injection into the hip with a steroid medication could be performed.
My Misery : A true, personal story from the experience, I Have Pigmented Villonodular Synovitis. I am 26 years old and have been diagnosed with PVNS in my left hip for the last 5 years. I remember the symptoms started back when I was 14 years old. I had my first synovectomy in 2005 at the age of...
Pvns ? You Couldnt Make This Disease Up. : A true, personal story from the experience, I Have Pigmented Villonodular Synovitis. Hi Simon here, 45, diagnosed 4 weeks ago, had an arthroscopic synovectomy last Monday.. Went well, up and walking. I normally post on the facebook group pvns is pants.. I guess Im looking to find a...
title:Radiotherapy for Pigmented Villonodular Synovitis: A Case Report. Author:Navin Nayan, Vikas K Jagtap. Keywords:Radiotherapy, PVNS (Pigmented Villonodular Synovitis), Surgery. Type:Case report. Abstract:This is a case report of a 13 year old boy who has been operated for Pigmented Villonodular Synovitis (PVNS) and treated with adjuvant post-operative radiotherapy for incomplete surgical resection. This report mainly highlights the role of radiotherapy in managing this rare benign condition with emphasis on improving local control rates with functional joint preservation and avoiding repeated surgeries.. ...
Pignmented villonodular synovitis or PVNS is a benign tumor in the joint. Learn about the symptoms PVNS and treatment options for PVNS.
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When a blood-filled growth occurs in the bones of the arms, legs, skull, trunk or spine, then it might be an aneurysmal bone cyst.
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
TY - JOUR. T1 - Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas. AU - Graham, Rondell. AU - Krishnamurthy, Smita. AU - Oliveira, Andre. AU - Inwards, Carrie. AU - Folpe, Andrew L.. PY - 2012/10/1. Y1 - 2012/10/1. N2 - Osteomalacia has multiple aetiologies including the least common, tumour-induced osteomalacia (TIO). Recently, most cases of TIO have been confirmed to be due to phosphaturic mesenchymal tumour of mixed connective tissue type (PMTMCT). Most cases of TIO are the result of production of the fibroblast growth factor-23 (FGF-23) by the tumour. The authors recently showed reverse transcriptase PCR (RT-PCR) for FGF-23 to be valuable in the diagnosis of PMTMCT. However, the authors also noted FGF-23 expression in some cases of aneurysmal bone cyst (ABC) and chondromyxoid fibroma (CMF). For the present study, the authors studied FGF-23 expression by RT-PCR in 19 cases of ABC and eight cases of CMF, all with typical ...
The global Pigmented Villonodular Synovitis Drug market is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2018...
TY - JOUR. T1 - Aneurysmal bone cyst involving the lunate. AU - Mankin, K. P.. AU - Bischoff, R. J.. AU - Gelberman, R. H.. AU - Rosenberg, Andrew. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Aneurysmal bone cysts are rare lesions which even more rarely involve the bones of the hand. We report a case of a cyst involving the lunate which was initially mistaken for interosseous ganglion. Due to delay in diagnosis, marked destruction of the lunate occurred, necessitating excision and scapho-capitate arthrodesis. Although rare, aneurysmal bone cysts should be included in the differential diagnosis and ruled out prior to embarking on a course of treatment.. AB - Aneurysmal bone cysts are rare lesions which even more rarely involve the bones of the hand. We report a case of a cyst involving the lunate which was initially mistaken for interosseous ganglion. Due to delay in diagnosis, marked destruction of the lunate occurred, necessitating excision and scapho-capitate arthrodesis. Although rare, aneurysmal bone ...
Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. An 11-year-old girl presented to our OPD with complaints of pain and a gradually progressive swelling of the right great toe. On examination, the swelling was diffuse with no signs of inflammation. X-ray examination revealed a well-defined, longitudinally oval lytic lesion in the right distal phalanx of great toe, involving the growth plate and, eroding the medial cortex. Computed tomography (CT) scan did not show any evidence of calcification, septations or involvement of soft tissue. Open biopsy and curettage was done and the specimen was sent for histopathological examination. Histopathological examination (HPE) showed a lobular pattern consisting of myxomatous
In the single dose Part A of the study, patients receive 1 dose of of 10 mg/kg MCS110 administered i.v. on Day 1.. In the multiple dose Part B patients receive up to 6 doses of 10 mg/kg MCS110 administered i.v. once every 4 weeks starting at Day 1, or at Day 29 if the first dose received was placebo.. In the multiple dose Part C patients receive up to 6 doses of 3 mg/kg or 5 mg/kg or 10 mg/kg MCS110 administered i.v. once every 4 weeks starting at Day 1. ...
BACKGROUND: The finding of a cytogenetic-pathologic correlation between complex karyotypes and high grade cartilaginous tumors has been reported. However, few cytogenetic reports exist regarding benign or low grade lesions. A subset of low grade malignant cartilaginous tumors is characterized by locally aggressive behavior but no metastatic potential. Because the histopathologic distinction between benign, borderline, or low grade malignant cartilaginous lesions can be difficult, the finding of additional tumor markers associated with the clinical behavior of borderline cartilaginous lesions could be clinically significant.. METHODS: Four cartilaginous tumors, including an osteochondroma (OC), a chondromyxoid fibroma (CF), an enchondroma (EC), and a dedifferentiated chondrosarcoma (DCS), were cultured and harvested using short term, in situ culture techniques. Chromosome analysis was performed by conventional G-banding and fluorescence in situ hybridization was used to confirm ...
Aneurysmal bone cyst. X-ray showing an aneurysmal bone cyst (dark patch, upper left) on the lower fibula (calf bone) of a patients leg. This cyst is a lesion on the bone which has a thin wall containing blood filled cyst cavities. A giant cell tumour is the most common cause, although it may be due to an injury of the bone. - Stock Image C003/6331
In the hip, bone lesions typically develop at the junction of the femoral head and neck, and acetabulum. Additionally, erosions are more commonly seen than in the knee due to the tight capsule of the hip joint.. ...
Purpose of the study Case report of a five-year-old boy presenting with a painless swelling of the left knee with decreased range of motion ...
Jan 16, 2018. PARIS - The Latest on Airbus (all times local): 9:50 a.m. Airbus says it sold more than 1,100 planes last year, outselling rival Boeing thanks to a raft of end-of-year deals and a growing global economy and travel demand. The European planemaker reported Monday that it delivered 718 planes in 2017, fewer than Boeings 763 but a record for Airbus. Outgoing CEO Fabrice Bregier said Airbus will speed up production in the coming year, notably of its long-delayed widebody A350, and hopes to out-deliver Boeing by 2020. Bregier acknowledged challenges ahead but called them manageable. Airbus is facing multiple corruption... ...
Aneurysmal bone cysts are rare pseudocysts, commonly seen in long bones and vertebral column. Although a well described and reported lesion, many misconceptions still prevail regarding their etiopathogenesis. Many of the reported cases of jaw aneurys
Background: Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis...
Learn about the symptoms, diagnosis and treatment of pigmented villonodular synovitis (PVNS), a condition that can cause joint pain and… ...
We went to the Orthopedic Surgeon today and he has a probable prognosis according to the MRI results. He is pretty certain that it is Pigmented Villonodular Synovitis (PVNS). When looking at the MRI, he found swollen tissue around her knee joint, thus producing fluid. This swollen tissue and fluid is what is hindering her walking. The Doctor is planning to get a tissue sample and draw some of the fluid out to test and be 100% certain that its PVNS ...
Free, official coding info for 2020 ICD-10-CM M12.239 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Dr. Michalski responded: ABC. Aneurysmal bone cysts treated surgically heal in approximately 6 weeks--depending on the personality and location and size of the cyst. If it is fractured/displaced it may take somewhat longer.
Khalil, G E W (1980). "Benign chondroblastoma. A case report and review of the literature". Le Journal Médical Libanais. 31 (1 ...
Epiphyseal lesions include chondroblastoma and giant-cell tumor. Long bone Longitudinal section of head of left humerus. ...
Somatic mutations in the H3F3B gene are associated with chondroblastoma. A rare de novo germline mutation of the H3F3B gene ( ... "Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone". Nature Genetics. 45 (12): 1479- ...
An aneurysmal bone cyst can arise from a pre-existing chondroblastoma, a chondromyxoid fibroma, an osteoblastoma, a giant cell ...
... chondroblastoma is composed of cells resembling the precursor of chondrocytes. Many types of blastoma have been linked to a ...
These include, aneurysmal bone cyst, chondroblastoma, simple bone cyst, osteoid osteoma, osteoblastoma, osteosarcoma, giant- ...
... insufficiency Cholesterol ester storage disease Cholesterol esterification disorder Cholesterol pneumonia Chondroblastoma ...
... chondroblastoma MeSH C04.557.450.565.265 - chondroma MeSH C04.557.450.565.265.270 - chondromatosis MeSH C04.557.450.565.280 - ...
NOS Chondromatous giant cell tumor Codman tumor M9230/3 Chondroblastoma, malignant M9231/3 Myxoid chondrosarcoma M9240/3 ... chondroma Periosteal chondroma M9221/3 Juxtacortical chondrosarcoma Periosteal chondrosarcoma M9230/0 Chondroblastoma, ...
Chondroblastoma - Chondrocyte - Chondrogenesis - Chondromalacia patellae - Chondromyxoid fibroma - Chondrosarcoma - Chopart's ...
Damron, Timothy A. "Chondroblastoma." MedScape (2014). Web. 6 Dec. 2015 Turcotte, Robert E., et al. "Chondroblastoma." Human ... There is no indication of a racial predilection for chondroblastoma. The etiology of chondroblastoma is uncertain, as there is ... have better prognoses than patients with atypical chondroblastoma (flat bones, skull, etc.). Chondroblastoma was first ... Chondroblastoma shows a predilection towards the male sex, with a ratio of male to female patients of 2:1. The most commonly ...
Pain may be relieved by nonsteroidal anti-inflammatory drugs.. Treatment varies based on the health of the patient. If he/she is otherwise healthy and is not significantly bothered by the pain, the tumor is treated symptomatically with anti-inflammatories. If this therapy fails or the location of the tumor could lead to growth disturbances, scoliosis, or osteoarthritis, surgical or percutaneous ablation may be considered.[10] If surgery is preferred, the individual may be referred to a podiatrist or an orthopedic surgeon to perform the procedure. Post-surgery therapy and strengthening may be needed, depending on the tumor location and health of the individual. While shown to be effective, surgical resection has many potential complications, including difficult intraoperative identification of the tumor, local recurrence from incomplete resection, and resection of weight bearing bone that can necessitate prolonged hospital stays and complicate recovery.[11]. Recently, CT guided radiofrequency ...
Damron, Timothy A. "Chondroblastoma." MedScape (2014). Web. 6 Dec. 2015 Turcotte, Robert E., et al. "Chondroblastoma." Human ... There is no indication of a racial predilection for chondroblastoma. The etiology of chondroblastoma is uncertain, as there is ... have better prognoses than patients with atypical chondroblastoma (flat bones, skull, etc.). Chondroblastoma was first ... Chondroblastoma shows a predilection towards the male sex, with a ratio of male to female patients of 2:1. The most commonly ...
A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. In 1931, ... encoded search term (Chondroblastoma) and Chondroblastoma What to Read Next on Medscape. Related Conditions and Diseases. * ... Chondroblastoma Treatment & Management. Updated: Dec 03, 2018 * Author: Timothy A Damron, MD; Chief Editor: Omohodion (Odion) ... RFA for chondroblastoma has been described in several reports, but follow-up has been shorter than for surgical treatment, and ...
Chondroblastoma. What is chondroblastoma? A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage ... How is chondroblastoma treated? The goal for treatment of chondroblastoma is to remove the tumor and prevent damage to the end ... Key points about chondroblastoma Chondroblastoma is a rare type of noncancerous bone tumor that starts from cartilage. It most ... What causes chondroblastoma? The exact cause of chondroblastoma is not known. The tumors are believed to start from immature ...
The official designation of a primary bone tumor as a chondroblastoma depends on the histologic finding of foci of chondroid ... Chondroblastoma is a rare benign bone tumor of chondroblast origin that almost always occurs in a primary or secondary site of ... encoded search term (Chondroblastoma Pathology) and Chondroblastoma Pathology What to Read Next on Medscape. Related Conditions ... Chondroblastoma is a rare benign bone tumor of chondroblast origin [1] that almost always occurs in a primary or secondary site ...
... oncology center offers expert diagnosis and treatment for patients with a rare benign bone tumor called chondroblastoma. ... Symptoms of Chondroblastoma. Symptoms of chondroblastoma may vary depending on where the tumor is located. However, pain in the ... Chondroblastoma, sometimes called Codmans tumor, is a rare type of benign (non-cancerous) bone tumor that is comprised of ... Some of the more common symptoms of chondroblastoma include:. *Pain in the knee, hip, and/or shoulder joint, especially pain ...
Chondroblastoma is a rare, benign bone tumor found in the rounded ends (epiphysis - secondary growth centers) of the long bones ... What is chondroblastoma?. Chondroblastoma is a rare, benign bone tumor found in the rounded ends (epiphysis - secondary growth ... Depending on the size and location of chondroblastoma removed, your child may be able to return home that day or may spend one ... There is a 10 percent risk of recurrence of chondroblastoma after treatment, so it is important for your child to continue to ...
A. J. Ramappa, F. Y. I. Lee, P. Tang, J. R. Carlson, M. C. Gebhardt, and H. J. Mankin, "Chondroblastoma of bone," The Journal ... S. H. Sohn, S. A. Koh, D. G. Kim et al., "A case of spine origin chondroblastoma metastasis to lung," Cancer Research and ... F. Sailhan, F. Chotel, and R. Parot, "Chondroblastoma of bone in a pediatric population," Journal of Bone and Joint Surgery- ... Chondroblastoma of the Knee Treated with Resection and Osteochondral Allograft Reconstruction. Judd Fitzgerald,1 Cory Broehm,2 ...
... Ichiro Tonogai,1 Mitsuhiko Takahashi,1 ... Ichiro Tonogai, Mitsuhiko Takahashi, Hiroaki Manabe, et al., "A Massive Chondroblastoma in the Proximal Humerus Simulating ...
Keywords : benign chondroblastoma; occipital bone; cartilaginous tumor; skull. · abstract in Portuguese · text in Portuguese · ... Chondroblastoma arising from the occipital bone is extremely rare. We report the case of a 16 year old girl with a benign ... Benign chondroblastoma is a rare bone tumor of immature cartilage cell derivation. This lesion classically occur at the ends of ... Benign chondroblastoma of the occipital bone: case report. Arq. Neuro-Psiquiatr. [online]. 1995, vol.53, n.4, pp.834-836. ISSN ...
Chondroblastoma. What is chondroblastoma?. Sometimes called Codmans tumor, a chondroblastoma is a rare type of benign ( ... Treatment for chondroblastoma. Specific treatment for chondroblastoma will be determined by your doctor based on:. *Your age, ... What causes chondroblastoma?. The exact cause of chondroblastoma is not known. The tumors are believed to originate from ... What are the symptoms of chondroblastoma?. Symptoms of chondroblastoma may vary depending on the location of the tumor. The ...
Chondroblastoma. In: Human Pathology 1993;24(9):944-49. [ Links ]. 4. Fines BP, Stacy GS. Chondroblastoma imaging. In: Medscape ... Benign chondroblastoma. In: JBJS (Br) 1966;48-B:92-104. [ Links ]. 3. Turcotte RE, Kurt A, Sim FH, Unni KK, McLeod RA. ... Chondroblastoma. In: Journal of Orhtopaedic Surgery 2008; 16(1):84-87. [ Links ]. 14. Suneja R, Grimer RJ, Belthur M, Jeys L, ... Benign chondroblastoma. In: JBJS (Br) 1956;38-A:817-26. [ Links ]. 17. Isler MH, Turcotte RE. Bone tumours in children. In: ...
Chondroblastoma of bone. J Bone Joint Surg [Am] 2000;82:1140-5. doi: 10.1302/0301-620X.82B8.10791. [PubMed] [Cross Ref] ... Pulmonary metastases from chondroblastoma of the tibia. Report of a case. J Bone Joint Surg [Br] 1973;55(4):848-53. [PubMed] ... Benign chondroblastoma of bone. Report of a case. J Bone Joint Surg [Br] 1975;57(1):78-81. [PubMed] ... Chondroblastoma of the pelvis suggestive of malignancy. J Bone Joint Surg [Am] 1975;57(4):549-51. [PubMed] ...
Chondroblastoma; p 247-64.. *Strong DP, Grimer RJ, Carter SR, Tillman RM, Abudu A. Chondroblastoma of the femoral head: ... Chondroblastoma is a rare tumor that represents 1% to 2% of all primary bone tumors. [1-7] Prior to being defined as a distinct ... Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol. 1985;14(1):1-9.Crim JR, Gold RH, Mirra JM, ... Surgical Dislocation of the Hip for the Treatment of a Femoral Head Chondroblastoma. A 17-year-old, high-level female athlete ...
The association of metastatic chondroblastoma, elevated CK, and an evolving profile of paraneoplastic autoantibodies reveals a ... Locally recurrent chondroblastoma was excised 1 year later. Serum CK was elevated, CRMP-5-IgG was positive, PCA-2 was lower, ... A 17-year-old girl presented with chondroblastoma of the fibula and pulmonary metastases. Serum creatine kinase (CK) was ... Chondroblastoma and chondromyxoid fibroma.. *Camila B R De Mattos, Chanika Angsanuntsukh, Alexandre Arkader, John P Dormans ...
Although a majority of them are benign, few can become malignant and even metastasize.… Chondroblastoma: Read more about ... Chondroblastoma also known as Codman tumor, calcifying giant cell tumor or epiphyseal chondromatous giant cell tumor is a rare ... Chondroblastoma. Hum Pathol. 1993;24:944-949.. *Bloem JL, Mulder JD. Chondroblastoma: a clinical and radiological study of 104 ... Benign metastasizing chondroblastoma: a case report. Cancer. 1998;82:675-678. *Kricun ME, Kricun R, Haskin ME. Chondroblastoma ...
Treatment of a Chondroblastoma of Proximal Humerus with Intralesional Curettage Resection, Cryosurgery and Bone Grafting ... Secondary aneurysmal bone cyst frequently correlated with chondroblastoma. *Chondroblastomas have been reported to transform ... there is always a risk of growth plate failure from the chondroblastoma since it usually grows adjacent to the growth plate and ...
Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in ... Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in ... Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in ... Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in ...
... most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the ... A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly ... Chondroblastoma. What is chondroblastoma? A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage ... How is chondroblastoma treated? The goal for treatment of chondroblastoma is to remove the tumor and prevent damage to the end ...
... most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the ... A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the specialized, gristly ...
This appearance is consistent with a chondroblastoma. The... ... Chondroblastoma. This 24-years old man had pain in the left ... ABC transformation in a chondroblastoma is not uncommon and the presence of fluid-fluid levels should not prevent us from ... This appearance is consistent with a chondroblastoma. The MRI (Figs. 2, 3) showed a lesion with fluid-fluid levels. Such levels ... You can also see the other examples of a chondroblastoma in the tibial epiphysis and femoral head. ...
Aggressive chondroblastoma of the distal tibia is rare, and below-knee amputation had been the standard surgical procedure. We ... fibular graft and ankle arthrodesis may be an effective and economical alternative method for aggressive chondroblastoma in the ... Aggressive chondroblastoma of the distal tibia is further rare. For patients with aggressive chondroblastoma, treatments ... At times, chondroblastoma may be aggressive in character. Primary malignant form as well as malignant alteration in the form of ...
Chondroblastoma. What is chondroblastoma?. A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage ... How is chondroblastoma treated?. The goal for treatment of chondroblastoma is to remove the tumor and prevent damage to the end ... What causes chondroblastoma?. The exact cause of chondroblastoma is not known. The tumors are believed to start from immature ... Key points about chondroblastoma. *. Chondroblastoma is a rare type of noncancerous bone tumor that starts from cartilage. ...
Chondroblastoma and osteoblastoma Chondroblastoma and osteoblastoma are 2 types of bone tumours that are intermediate tumours. ...
Chondroblastoma. A review of seventy cases. Chondroblastoma. Chondroblastoma of Bone.. Chondroblastoma of bone: long-term ... Treatment and Prognosis of Chondroblastoma. Chondroblastoma of bone in the extremities: a multicenter retrospective study. ... Chondroblastoma. - See: Bone Tumor Menu - Discussion: - age at presentation: - most common primary epiphyseal tumor in children ... Histology of Chondroblastoma: - may contain areas that are histologically identical to aneurysmal bone cyst - Treatment: - ...
Chondroblastoma. Chondroblastoma is a rare type of benign (noncancerous) tumor that usually develops at the ends of long bones ... A chondroblastoma is usually small and contained within the bone, so patients do not normally see or feel a mass. ... Pain is the most common symptom of chondroblastoma. Because these tumors are typically found near joints, patients often see ... This type of chondroblastoma is often referred to as a "Codmans tumor." Sometimes, chondroblastomas are found in the pelvis, ...
Chondroblastoma. A review of seventy cases.. Springfield, D S; Capanna, R; Gherlinzoni, F; More ...
Chondroblastoma , Surgical resection. Treatment in Cologne, Germany ✈ Find the best medical programs at BookingHealth - ✔ ... Surgical resection of benign chondroblastoma #211009. The Department of General, Abdominal and Tumor Surgery deals with the ... Surgical resection of benign chondroblastoma #219183. With a team of 15 physicians having different surgical specialties, the ...
We describe the main radiologic and histologic characteristics of chondroblastoma and compare them to those of frequently ... Report of the first case of chondroblastoma involving the sinonasal cavity and ventral skull base, offering a description of ... Chondroblastoma, Endoscopy, Skull base, Bone tumor Introduction. Chondroblastoma is a rare neoplasm of the bone constituting ... Chondroblastoma of Ventral Skull Base: First Report of a Case Ahmad Elkhatib1, Paul Wakely Jr2, Luciano M Prevedello3, Ralph ...
EPIPHYSEAL CHONDROBLASTOMA OF BONE. VALLS, JOSÉ; OTTOLENGHI, CARLOS E.; SCHAJOWICZ, FRITZ VALLS, JOSÉ; OTTOLENGHI, CARLOS E.; ...
Diagnosis of benign chondroblastoma (costs for program #219337) ✔ Academic Hospital Cologne-Holweide ✔ Department of Internal ... Academic Hospital Cologne-Holweide › Diagnosis of benign chondroblastoma: Costs for treatment #219337 in Germany - ... Diagnosis of benign chondroblastoma,price:{val:0,type:val},extra_service_clinic:[],extra_service:[],translation_ ...
  • Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. (wikipedia.org)
  • The highly heterogeneous nature of the tumor makes classification particularly difficult especially considering the origins of chondroblastoma. (wikipedia.org)
  • A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. (rochester.edu)
  • Symptoms of chondroblastoma may vary depending on the location of the tumor. (rochester.edu)
  • The goal for treatment of chondroblastoma is to remove the tumor and prevent damage to the end of the affected bone. (rochester.edu)
  • Chondroblastoma is a rare type of noncancerous bone tumor that starts from cartilage. (rochester.edu)
  • The official designation of a primary bone tumor as a chondroblastoma depends on the histologic finding of foci of chondroid matrix, and/or chondroblasts, which are typically rounded cells with clearly distinct cell borders separating them from each other and from the matrix. (medscape.com)
  • Chondroblastoma, sometimes called Codman's tumor, is a rare type of benign (non-cancerous) bone tumor that is comprised of chondroblasts (cartilage cells). (cooperhealth.org)
  • Chondroblastoma is a rare, benign bone tumor found in the rounded ends (epiphysis - secondary growth centers) of the long bones in the arms and legs. (chop.edu)
  • Differential diagnosis at this time included chondroblastoma, giant cell tumor, clear cell chondrosarcoma, and osteomyelitis. (hindawi.com)
  • Core needle biopsy (Figure 2 ) showed mononuclear neoplastic cells with intermixed multinucleated giant cells, tumor cells surrounded by dark blue "chicken wire" calcifications, and fibrochondroid islands all consistent with a chondroblastoma. (hindawi.com)
  • Benign chondroblastoma is a rare bone tumor of immature cartilage cell derivation. (scielo.br)
  • Sometimes called Codman's tumor, a chondroblastoma is a rare type of benign (noncancerous) bone tumor that originates from cartilage. (nyhq.org)
  • Chondroblastoma is a rare type of bone tumor that can affect people of all ages. (nyhq.org)
  • Chondroblastoma is a rare tumor that represents 1% to 2% of all primary bone tumors. (icjr.net)
  • Chondroblastoma also known as Codman tumor, calcifying giant cell tumor or epiphyseal chondromatous giant cell tumor is a rare tumor occurring in young patients. (symptoma.com)
  • Chondroblastoma is a rare type of benign (noncancerous) tumor that usually develops at the ends of long bones, such as the thighbone and upper arm bone. (emoryhealthcare.org)
  • This type of chondroblastoma is often referred to as a "Codman's tumor. (emoryhealthcare.org)
  • Chondroblastoma of the skull base is an exceedingly rare tumor with varying prognosis. (clinmedjournals.org)
  • Chondroblastoma is a benign tumor of immature cartilage cells which primarily occurs in the epiphysis of long bones in the second decade of life with slight male preponderance. (faoj.org)
  • 2 ] A decade later, Jaffe and Lichtenstein renamed it as chondroblastoma and clearly separated it from giant cell tumor. (faoj.org)
  • Chondroblastoma is a rare benign tumor mainly occurred in epiphyses and apophyses of long bones, and usually affects the young people. (researchsquare.com)
  • Chondroblastoma is a rare tumor, representing only 1-3% of all primary bone tumors, with local pain and swelling lasting for several months as the most important symptoms. (jocponline.com)
  • Unlike previously published examples of metastatic chondroblastoma , these metastasis developed before any operative manipulation of the primary tumor . (bvsalud.org)
  • Chondroblastoma Epiphyses Giant Cell tumor Epiphyses Adamantinoma Tibia Chordoma Sacrum. (scribd.com)
  • Simple bone cyst Proximal humerus Chondroblastoma Epiphyses Giant Cell tumor Epiphyses Chordoma Sacrum. (scribd.com)
  • Cavities filled with blood can also be found in giant cell tumor, osteoblastoma and chondroblastoma (i.e with secondary ABC). (amazonaws.com)
  • The doctor gave three different possibilities-A Chondroblastoma Bone Tumor, a Giant Cell Tumor or a bone infection. (gofundme.com)
  • Approximately 92% of patients presenting with chondroblastoma are younger than 30 years. (wikipedia.org)
  • Chondroblastoma is very uncommon, accounting for only 1-2% of all bone tumors. (wikipedia.org)
  • The etiology of chondroblastoma is uncertain, as there is no specific characteristic abnormality or chromosomal breaking point observed, despite cytogenetic abnormalities being highly specific for some tumors. (wikipedia.org)
  • Chondroblastoma was first described by Codman in 1928 as "epiphyseal chondromatous giant cell tumors of the proximal humerus" [ 1 ]. (hindawi.com)
  • A Massive Chondroblastoma in the Proximal Humerus Simulating Malignant Bone Tumors," Case Reports in Orthopedics , vol. 2013, Article ID 673576, 5 pages, 2013. (hindawi.com)
  • Chondroblastoma is a rare neoplasm of the bone constituting approximately 1% of all primary bone tumors. (clinmedjournals.org)
  • Chondroblastoma is a rare benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors and characteristically arises in the epiphysis of a long bone , particularly the humerus , tibia , and femur . (bvsalud.org)
  • The histologic characteristics of the primary, metastatic tumors were those of a conventional chondroblastoma . (bvsalud.org)
  • The WHO classification describes several benign cartilaginous bone tumors being: osteochondroma, enchondroma, periosteal chondroma, chondromyxoid chondroma and chondroblastoma. (lumc.nl)
  • Chondroblastoma tumors destroy surrounding bone, causing pain during movement and at rest. (chla.org)
  • The most common surgical procedure used for chondroblastoma is curettage, with or without autograft or allograft bone grafting. (medscape.com)
  • Osteochondral allograft reconstruction is an effective option following marginal resection and curettage of chondroblastoma involving the chondral surface of the distal femur. (hindawi.com)
  • What Happens to the Articular Surface After Curettage for Epiphyseal Chondroblastoma? (wheelessonline.com)
  • The primary treatment for chondroblastoma is intralesional curettage. (researchsquare.com)
  • The aim of this study was to evaluate the clinical and radiologic results of patients suffering chondroblastoma treated with intralesional curettage, electrocauterization of the cavity and bone grafting. (researchsquare.com)
  • From January 2000 to January 2010, 15 patients with chondroblastoma were treated with intralesional curettage and electrocauterization of the cavity, among which14 patients received bone grafting. (researchsquare.com)
  • Thorough curettage with electrocauterization and bone grafting has a good functional outcome in the treatment of chondroblastoma, but still has a low risk of recurrence and complications. (researchsquare.com)
  • Patella is a relative uncommon site for chondroblastoma.Most of cases of chondroblastoma in patella reported in literature are treated with patellectomy.We treated a large chondroblastic lesion in patella of an 22 year old male with curettage, burring and bone graft and the result was satisfactory after 8 months postoperation,with complete consolidation of new bone on radiographs, absence of pain and full range of knee motion. (jocponline.com)
  • Chondroblastoma-like chondroma of soft tissue: report of the first case in the base of skull. (md-medicaldata.com)
  • This case report describes the operative management of 16-year-old male with a symptomatic chondroblastoma of the distal femur with breach of the chondral surface. (hindawi.com)
  • A rare case of metaphyseodiaphyseal chondroblastoma of proximal femur presenting with constitutional symptoms in a six-year-old child. (symptoma.com)
  • Additionally, rare prevalence of chondroblastoma in intra-membranous ossification suggests a close relationship with growth plate cartilage. (wikipedia.org)
  • In chondroblastoma, growth signaling molecules may be present due to the pre-pubertal signaling network as well as cartilage growth. (wikipedia.org)
  • The work of Aigner et al suggests that chondroblastoma should be reclassified as a bone-forming neoplasm versus a cartilaginous neoplasm due to the presence of osteoid matrix, type I collagen, and absence of true cartilage matrix (collagen II). (wikipedia.org)
  • generally, because the bones at the base of the skull develop from cartilage, they have a greater potential for developing chondroblastoma. (medscape.com)
  • [ 17 ] On these images, the chondroblastoma may mimic aneurysmal bone cysts, which are also expansile and osteolytic. (medscape.com)
  • It is uncertain why chondroblastoma occurs, but it is sometimes found in conjunction with other growths, such aneurysmal bone cysts , which are found in 20-25 percent of all patients with chondroblastoma. (chop.edu)
  • Chondroblastoma and osteoblastoma are 2 types of bone tumours that are intermediate tumours. (cancer.ca)
  • To present a case of aggressive sacral osteoblastoma (OB) treated with neoadjuvant denosumab therapy and en bloc resection. (springer.com)
  • This appearance is consistent with a chondroblastoma. (typepad.com)
  • Aggressive chondroblastoma of the distal tibia is rare, and below-knee amputation had been the standard surgical procedure. (biomedcentral.com)
  • Double pedicel fibular graft and ankle arthrodesis may be an effective and economical alternative method for aggressive chondroblastoma in the distal tibia. (biomedcentral.com)
  • Aggressive chondroblastoma of the distal tibia is further rare. (biomedcentral.com)
  • The following image depicts the epiphyseal location of a chondroblastoma of the femoral head. (medscape.com)
  • Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. (aston.ac.uk)
  • Around 50% of the chondroblastoma in femoral head. (aston.ac.uk)
  • You can also see the other examples of a chondroblastoma in the tibial epiphysis and femoral head . (typepad.com)
  • Depending on the size and location of chondroblastoma removed, your child may be able to return home that day or may spend one night in the Hospital. (chop.edu)
  • We describe the main radiologic and histologic characteristics of chondroblastoma and compare them to those of frequently mistaken differential diagnoses. (clinmedjournals.org)
  • The differential diagnosis was now chondroblastoma or simple bone cyst. (scielo.org.za)
  • it was found that the average duration of symptoms for patients with chondroblastoma was about 20 months, ranging from 5 weeks to 16 years. (wikipedia.org)
  • What are the symptoms of chondroblastoma? (rochester.edu)
  • The following are the most common symptoms of chondroblastoma. (nyhq.org)
  • The symptoms of chondroblastoma may resemble other medical conditions or problems. (nyhq.org)
  • Chondroblastoma of the temporal bone: a case series, review, and suggested management strategy. (md-medicaldata.com)
  • Chondroblastoma of the temporal bone. (md-medicaldata.com)
  • Successful function-preserving therapy for chondroblastoma of the temporal bone involving the temporomandibular joint. (md-medicaldata.com)
  • Chondroblastoma of the temporal bone: consistent middle fossa involvement. (md-medicaldata.com)
  • 3. Chondroblastoma (Epiphyseal Chondroblastoma, Benign Chondroblastoma). (bokus.com)
  • This case report describes the management of a 15 year old male with a biologically aggressive chondroblastoma of the knee. (pubmedcentralcanada.ca)
  • Knee arthrodesis with simultaneous limb-lengthening is an effective treatment modality following en-bloc resection of an aggressive chondroblastoma. (pubmedcentralcanada.ca)
  • We report the case of a biologically aggressive chondroblastoma of the knee treated with a 13 cm en-bloc excision, knee arthrodesis, and bone transport using an Ilizarov ring fixator. (pubmedcentralcanada.ca)
  • For patients with aggressive chondroblastoma, treatments including below-knee amputation and arthrodesis have been recommended. (biomedcentral.com)
  • In this report, we describe the successful wide resection of aggressive chondroblastoma and reconstruction with double pedicel fibular graft and ankle arthrodesis. (biomedcentral.com)
  • An incisional biopsy revealed aggressive chondroblastoma with an aneurysmal bone cyst. (biomedcentral.com)
  • Microscopic image of aggressive Chondroblastoma showing the highly cellular tissue, variably differentiated and with discrete granulated to meshy calcification of the matrix and large multinuclear cells present in 20 % of cases. (biomedcentral.com)
  • Chondroblastoma is almost always found at sites of secondary ossification centers, notably the epiphyses and apophyses of long bones. (medscape.com)
  • On radiographic images, chondroblastoma is characterized by a well-defined osteolytic lesion involving an epiphysis or secondary ossification center (see the following image). (medscape.com)
  • The histology thus showed a chondroblastoma with a secondary aneurysmal bone cyst (solid variant). (scielo.org.za)
  • Journal Article] Secondary aneurysmal bone cyst following chondroblastoma of the patella. (nii.ac.jp)
  • ABC transformation in a chondroblastoma is not uncommon and the presence of fluid-fluid levels should not prevent us from making a diagnosis of a chondroblastoma. (typepad.com)
  • Case report of a 19-years-old male patient with final diagnosis of chondroblastoma. (clinmedjournals.org)
  • Recurrence rates of chondroblastoma have been reported to be higher when they have a component of aneurysmal bone cyst [7]. (symptoma.com)
  • RFA for chondroblastoma has been described in several reports, but follow-up has been shorter than for surgical treatment, and caution is recommended for cases in which the lesions are larger than 2.5 cm and when there is no subchondral bone support. (medscape.com)
  • Chondroblastoma in the foot most commonly occurs in subchondral areas of the talus and calcaneal apophysis. (faoj.org)
  • There is a 10 percent risk of recurrence of chondroblastoma after treatment, so it is important for your child to continue to see his surgeon after treatment. (chop.edu)
  • A 17-year-old girl presented with chondroblastoma of the fibula and pulmonary metastases. (semanticscholar.org)
  • The authors report the first case of chondroblastoma ethmoid-spheno-petro-clival associated with epidural abcces that was treated through curretage of the lesion, and drainage of the abccess and antibiotic treatment. (md-medicaldata.com)
  • Chondroblastoma - Surgical resection. (bookinghealth.com)
  • He was treated for 1 month with neoadjuvant denosumab followed by en bloc resection. (springer.com)
  • However, Edel et al found that collagen II, a marker for mature chondrocytes, was expressed in chondroblastoma, supporting the chondroid nature of the neoplasm. (wikipedia.org)
  • The results of Romeo and colleagues favor the view of Edel et al of chondroblastoma being cartilaginous in nature but recognize that any definitive determinations regarding the origin of this neoplasm are not possible because of the plasticity of mesenchymal cells when set into different microenvironments and static approaches used in literature. (wikipedia.org)
  • Romeo et al has noted that chondroblastoma arising in long bones mainly affects the epiphyses, while in other locations it is close to ossification centers. (wikipedia.org)
  • Chondroblastoma most often affects the ends of the long bones, near the growth plate, in the arms at the shoulder, and in the legs at the hip and knee. (rochester.edu)
  • In addition to long bones, chondroblastoma also occurs in the acetabular region of the pelvis, scapula, spine, and ribs. (sgh.com.sg)
  • Chondroblastoma is a rare benign bone tumour that usually occurs in children and young adults. (aston.ac.uk)
  • Chondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. (aston.ac.uk)
  • Chondroblastoma is a relatively rare, benign cartilaginous tumour, accounting for approximately 1% of the benign tumours of bone. (sgh.com.sg)
  • The patient underwent a 13 cm en-bloc excision of the knee, and knee arthrodesis with simultaneous bone transport using an Ilizarov ring fixator. (pubmedcentralcanada.ca)
  • How do you treat chondroblastoma of the knee? (healthtap.com)
  • Radiation therapy has been employed in the treatment of chondroblastoma but has essentially no current role in its treatment. (medscape.com)
  • Combination treatment of low-dose rapamycin, FM19G11, and leucine deprivation were inhibitory on the chondroblastoma cell line examined. (medscape.com)
  • Surgery is the recommended treatment for all children with chondroblastoma. (chop.edu)
  • Treatment of chondroblastoma depends on the size, location and patient age. (healthtap.com)
  • Chondroblastoma affects males more often than females at a ratio of 2:1 in most clinical reports. (wikipedia.org)
  • Totally, 15 patients with chondroblastoma were enrolled in our study, including 9 males and 6 females, with a mean age of 13 years old (range from 8 to 21 years). (researchsquare.com)
  • Presence of extensive surrounding reactive edema within the marrow and soft tissues, sclerotic margin, and presence of chondroid matrix are helpful features distinguishing chondroblastoma from GCT. (thefreedictionary.com)
  • There are two opposing views on the nature of chondroblastoma, one favoring an osseous origin and the other favoring a cartilaginous origin. (wikipedia.org)
  • Fusion of these genes prospects to the formation of an altered chromatin remodelling complex which lacks the subunit, resulting in transcriptional repression of tumour suppressor genes (e.g. mutations in giant cell tumour of chondroblastoma and bone, respectively, and mutations in central cartilaginous tumours. (saracatinib.info)
  • Chondroblastoma is a rare, usually benign, tumour and represent 1% of primary bone tumours. (md-medicaldata.com)
  • Dwaik M, Devlin PB: Case report: metadiaphyseal chondroblastoma. (symptoma.com)
  • Report of the first case of chondroblastoma involving the sinonasal cavity and ventral skull base, offering a description of the puzzling diagnostic process followed by its management. (clinmedjournals.org)
  • We report an unusual case of benign chondroblastoma of the talus in a 19 year-old female. (faoj.org)
  • a Case of a Benign Chondroblastoma of Bone with a Rare Localization]. (semanticscholar.org)
  • In this case a young man with pulmonary metastatic chondroblastoma on spine is presented. (bvsalud.org)
  • About 12% of all chondroblastoma occur in the bones of the foot. (faoj.org)
  • Metastatic chondroblastoma with elevated creatine kinase and paraneoplastic neurologic autoimmunity. (semanticscholar.org)