Choline-Phosphate Cytidylyltransferase: An enzyme that catalyzes the transfer of cytidylate (CMP) to choline phosphate to form CDPcholine. It is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. Its activity is increased by glucocorticoids. EC 2.7.7.15.Nucleotidyltransferases: A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Cytidine Diphosphate Choline: Donor of choline in biosynthesis of choline-containing phosphoglycerides.Maternal-Fetal Exchange: Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.Lipid Metabolism: Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Lecithins: A complex mixture of PHOSPHOLIPIDS; GLYCOLIPIDS; and TRIGLYCERIDES; with substantial amounts of PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; and PHOSPHATIDYLINOSITOLS, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholines. Lecithin is a component of the CELL MEMBRANE and commercially extracted from SOYBEANS and EGG YOLK. The emulsifying and surfactant properties are useful in FOOD ADDITIVES and for forming organogels (GELS).S-Adenosylmethionine: Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Docosahexaenoic Acids: C22-unsaturated fatty acids found predominantly in FISH OILS.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Myristic Acid: A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed)Myristic Acids: 14-carbon saturated monocarboxylic acids.Fatty Acids, Unsaturated: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Fatty Acids, Omega-3: A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Vaccines, Conjugate: Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.Pneumococcal Infections: Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Bacterial Capsules: An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.Nasopharynx: The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Web Browser: Software application for retrieving, presenting and traversing information resources on the World Wide Web.Programming Languages: Specific languages used to prepare computer programs.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Asia, Southeastern: The geographical area of Asia comprising BORNEO; BRUNEI; CAMBODIA; INDONESIA; LAOS; MALAYSIA; the MEKONG VALLEY; MYANMAR (formerly Burma), the PHILIPPINES; SINGAPORE; THAILAND; and VIETNAM.Developmental Biology: The field of biology which deals with the process of the growth and differentiation of an organism.Molecular Weight: The sum of the weight of all the atoms in a molecule.Accounts Payable and Receivable: Short-term debt obligations and assets occurring in the regular course of operational transactions.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)T-Phages: A series of 7 virulent phages which infect E. coli. The T-even phages T2, T4; (BACTERIOPHAGE T4), and T6, and the phage T5 are called "autonomously virulent" because they cause cessation of all bacterial metabolism on infection. Phages T1, T3; (BACTERIOPHAGE T3), and T7; (BACTERIOPHAGE T7) are called "dependent virulent" because they depend on continued bacterial metabolism during the lytic cycle. The T-even phages contain 5-hydroxymethylcytosine in place of ordinary cytosine in their DNA.Asia, Western: The geographical designation for the countries of the MIDDLE EAST and the countries BANGLADESH; BHUTAN; INDIA; NEPAL; PAKISTAN; and SRI LANKA. (From Random House Unabridged Dictionary, 2d ed, 1993 & Webster's New Geographical Dictionary, 1988)Nuclear Physics: The study of the characteristics, behavior, and internal structures of the atomic nucleus and its interactions with other nuclei. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Cercopithecus: A genus of Old World monkeys found in Africa although some species have been introduced into the West Indies. This genus is composed of at least twenty species: C. AETHIOPS, C. ascanius, C. campbelli, C. cephus, C. denti, C. diana, C. dryas, C. erythrogaster, C. erythrotis, C. hamlyni, C. lhoesti, C. mitis, C. mona, C. neglectus, C. nictitans, C. petaurista, C. pogonias, C. preussi, C. salongo, and C. wolfi.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.Phosphatidylethanolamine N-Methyltransferase: An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE.

Cellular responses to excess phospholipid. (1/270)

Phosphatidylcholine (PtdCho) is the major membrane phospholipid in mammalian cells, and its synthesis is controlled by the activity of CDP:phosphocholine cytidylyltransferase (CCT). Enforced CCT expression accelerated the rate of PtdCho synthesis. However, the amount of cellular PtdCho did not increase as a result of the turnover of both the choline and glycerol components of PtdCho. Metabolic labeling experiments demonstrated that cells compensated for elevated CCT activity by the degradation of PtdCho to glycerophosphocholine (GPC). Phospholipase D-mediated PtdCho hydrolysis and phosphocholine formation were unaffected. Most of the GPC produced in response to excess phospholipid production was secreted into the medium. Cells also degraded the excess membrane PtdCho to GPC when phospholipid formation was increased by exposure to exogenous lysophosphatidylcholine or lysophosphatidylethanolamine. The replacement of the acyl moiety at the 1-position of PtdCho with a non-hydrolyzable alkyl moiety prevented degradation to GPC. Accumulation of alkylacyl-PtdCho was associated with the inhibition of cell proliferation, demonstrating that alternative pathways of degradation will not substitute. GPC formation was blocked by bromoenol lactone, implicating the calcium-independent phospholipase A2 as a key participant in the response to excess phospholipid. Owing to the fact that PtdCho is biosynthetically converted to PtdEtn, excess PtdCho resulted in overproduction and exit of GPE as well as GPC. Thus, general membrane phospholipid homeostasis is achieved by a balance between the opposing activities of CCT and phospholipase A2.  (+info)

Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice. (2/270)

CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading. The goal of the present study was to use transgenesis to study the CT reaction in differentiated macrophages in vivo. We successfully created macrophage-targeted transgenic mice that overexpress a truncated form of CT, called CT-314. Sonicated homogenates of peritoneal macrophages overexpressing CT-314 protein demonstrated a two-fold increase in CT activity in vitro compared with homogenates from nontransgenic macrophages. CT-314 macrophages, however, demonstrated no increase in CT activity or PC biosynthesis in vivo. This finding could not be explained simply by intracellular mistargeting of CT-314, by the inability of CT-314 to associate with cellular membranes, or by substrate limitation. To further probe the mechanism, an in vitro assay using intact nuclei was developed in an attempt to preserve interactions between CT, which is primarily a nuclear enzyme in macrophages, and other nuclear molecules. This intact-nuclei assay faithfully reproduced the situation observed in living macrophages, namely, no significant increase in CT activity despite increased CT-314 protein. In contrast, CT activity in sonicated nuclei from CT-314 macrophages was substantially higher than that from nontransgenic macrophages. Thus, a sonication-sensitive interaction between excess CT and one or more nuclear molecules may be responsible for the limitation of CT activity in CT-314 macrophages. These data represent the first report of a CT transgenic animal and the first study of a differentiated cell type with excess CT.  (+info)

Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): combined action of upstream stimulatory and inhibitory cis-acting elements. (3/270)

CTP:phosphocholine cytidylyltransferase plays a key role in regulating the rate of phosphatidylcholine biosynthesis. However, the proximal regulatory elements for the gene (Ctpct) that encode this enzyme and the cognate transcription factors involved have not been characterized. Ctpct promoter activities were deduced from promoter deletion constructs linked to a luciferase reporter and transiently transfected into C3H10T1/2 and McArdle RH7777 cells. Positive regulatory elements were located between -130 and -52 bp from the transcription start site. Basal expression resided downstream between -52 and +38 bp. DNase I protection and electromobility-shift assays indicated that Sp1-related nuclear factors bind to a stimulatory, a possible inhibitory and minimal promoter element. Gel-shift assays confirmed that all three regulatory regions bound Sp1. Sp1 was further implicated when Sp1-deficient Drosophila cells were co-transfected with promoter-reporter constructs and an Sp1 construct. DNase I assays also indicated that the Ap1 binding elements could be occupied in the proximal activator and minimal promoter regions. Gel-shift assays demonstrated that the distal activator region could bind Ap1 and an unknown transcription factor. We conclude that Sp1, Ap1 and an unknown transcription factor have important roles in regulating expression of the Ctpct gene.  (+info)

Enzymatic and cellular characterization of a catalytic fragment of CTP:phosphocholine cytidylyltransferase alpha. (4/270)

To probe the mechanism of lipid activation of CTP:phosphocholine cytidylyltransferase (CCTalpha), we have characterized a catalytic fragment of the enzyme that lacks the membrane-binding segment. The kinetic properties of the purified fragment, CCTalpha236, were characterized, as well as the effects of expressing the fragment in cultured cells. CCTalpha236 was truncated after residue 236, which corresponds to the end of the highly conserved catalytic domain. The activity of purified CCTalpha236 was independent of lipids and about 50-fold higher than the activity of wild-type CCTalpha assayed in the absence of lipids, supporting a model in which the membrane-binding segment functions as an inhibitor of the catalytic domain. The kcat/Km values for CCTalpha236 were only slightly lower than those for lipid-activated CCTalpha. The importance of the membrane-binding segment in vivo was tested by expression of CCTalpha236 in CHO58 cells, a cell line that is temperature-sensitive for growth and CCTalpha activity. Expression of wild-type CCTalpha in these cells complemented the defective growth phenotype when the cells were cultured in complete or delipidated fetal bovine serum. Expression of CCTalpha236, however, did not complement the growth phenotype in the absence of serum lipids. These cells were capable of making phosphatidylcholine in the delipidated medium, so the inability of the cells to grow was not due to defective phosphatidylcholine synthesis. Supplementation of the delipidated medium with an unsaturated fatty acid allowed growth of CHO58 cells expressing CCTalpha236. These results indicate that the membrane-binding segment of CCTalpha has an important role in cellular lipid metabolism.  (+info)

Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. (5/270)

Phosphatidylcholine (PtdCho) is the most abundant phospholipid in mammalian cell membranes and is essential for cell viability. The levels of this lipid must be tightly controlled to maintain homeostasis. Therefore, changes in the rate of PtdCho synthesis are generally balanced by changes in PtdCho catabolism and vice versa. It is commonly accepted that the rate of PtdCho synthesis is regulated by CTP:phosphocholine cytidylyltransferase (CT). However, it is not certain if PtdCho mass is regulated by specific catabolic enzyme(s). Our goal is to determine if PtdCho homeostasis is regulated by a phospholipase A2 (PLA2). To this end, we have prepared Chinese hamster ovary (CHO) cell lines that overexpress CT. CT activity is 7-10-fold higher in the transfected cells than in parental CHO cells. This increase in CT activity is associated with increases in both PtdCho synthesis and PtdCho catabolism. Glycerophosphocholine is the PtdCho catabolite that accumulates in the transfected cells, which suggests that PtdCho turnover is mediated by a phospholipase A2 (PLA2). Indeed, higher levels of calcium-independent PLA2 activity are measured in the cytosols of the CHO cells that overexpress CT, compared to parental CHO cells. The elevated calcium-independent PLA2 activity is associated with increases in the expression of the 80-kDa calcium-independent PLA2 (iPLA2). Together, these data suggest that the 80-kDa iPLA2 may be modulated in response to changes in PtdCho levels and therefore is involved in the regulation of PtdCho homeostasis in CHO cells.  (+info)

Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits. (6/270)

The effects of atorvastatin (3 mg kg(-1)) and simvastatin (3 mg kg(-1)) on hepatic enzyme activities involved in very low density lipoprotein metabolism were studied in coconut oil/cholesterol fed rabbits. Plasma cholesterol and triglyceride levels increased 19 and 4 fold, respectively, after 7 weeks of feeding. Treatment with statins during the last 4 weeks of feeding abolished the progression of hypercholesterolaemia and reduced plasma triglyceride levels. 3-Hydroxy-3-methyl-glutaryl Coenzyme A reductase, acylcoenzyme A:cholesterol acyltransferase, phosphatidate phosphohydrolase and diacylglycerol acyltransferase activities were not affected by drug treatment. Accordingly, hepatic free cholesterol, cholesteryl ester and triglyceride content were not modified. Simvastatin treatment caused an increase (72%) in lipoprotein lipase activity without affecting hepatic lipase activity. Atorvastatin caused a reduction in hepatic phospholipid content and a compensatory increase in CTP:phosphocholine cytidylyl transferase activity. The results presented in this study suggest that, besides the inhibitory effect on 3-hydroxy-3-methyl-glutaryl Coenzyme A reductase, simvastatin and atorvastatin may have additional effects that contribute to their triglyceride-lowering ability.  (+info)

Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) --> G(1) transition. (7/270)

The transition from quiescence (G(0)) into the cell division cycle is marked by accelerated phospholipid turnover. We examined the rates of phosphatidylcholine (PC) synthesis and the activity, membrane affinity, and intracellular localization of the rate-limiting enzyme in the synthesis of PC, CTP:phosphocholine cytidylyltransferase (CT) during this transition. The addition of serum to quiescent IIC9 fibroblasts resulted in a wave of PC synthesis beginning at approximately 10 min, peaking at approximately 3 h with a >10-fold increase in rate, and declining to near basal rates by 10 h. CT activity, monitored in situ, was elevated approximately 3-fold between 1 and 2 h postserum. Neither CT mass nor its phosphorylation state changed during the surge in PC synthesis and CT activity. On the other hand, the ratio of particulate/soluble CT surged and then receded in concert with the wave of PC synthesis. During quiescence, CT was confined to the nucleus, as assessed by indirect immunofluorescence. Within 10 min after serum stimulation, a portion of the CT fluorescence appeared in the cytoplasm, where it intensified until approximately 4 h postserum. Thereafter, the cytoplasmic CT signal waned, while the nuclear signal increased, and by 8 h CT was once again predominantly nuclear. The dynamics of CT's apparent translocation in and out of the nucleus paralleled the wave of PC synthesis and the solubility changes of CT. Cytoplasmic CT co-localized with BiP, a resident endoplasmic reticulum protein, in a double labeling experiment. These data suggest that the wave of PC synthesis that accompanies the G(0) --> G(1) transition is regulated by the coordinated changes in CT activity, membrane affinity, and intracellular distribution. We describe for the first time a redistribution of CT from the nucleus to the ER that correlates with an activation of the enzyme. We propose that this movement is required for the stimulation of PC synthesis during entry into the cell cycle.  (+info)

Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. (8/270)

CTP:phosphocholine cytidylyltransferase is a major regulator of phosphatidylcholine biosynthesis. A single isoform, CCTalpha, has been studied extensively and a second isoform, CCTbeta, was recently identified. We identify and characterize a third cDNA, CCTbeta2, that differs from CCTbeta1 at the carboxyl-terminal end and is predicted to arise as a splice variant of the CCTbeta gene. Like CCTalpha, CCTbeta2 is heavily phosphorylated in vivo, in contrast to CCTbeta1. CCTbeta1 and CCTbeta2 mRNAs were differentially expressed by the human tissues examined, whereas CCTalpha was more uniformly represented. Using isoform-specific antibodies, both CCTbeta1 and CCTbeta2 localized to the endoplasmic reticulum of cells, in contrast to CCTalpha which resided in the nucleus in addition to associating with the endoplasmic reticulum. CCTbeta2 protein has enzymatic activity in vitro and was able to complement the temperature-sensitive cytidylyltransferase defect in CHO58 cells, just as CCTalpha and CCTbeta1 supporting proliferation at the nonpermissive conditions. Overexpression experiments did not reveal discrete physiological functions for the three isoforms that catalyze the same biochemical reaction; however, the differential cellular localization and tissue-specific distribution suggest that CCTbeta1 and CCTbeta2 may play a role that is distinct from ubiquitously expressed CCTalpha.  (+info)

*Choline-phosphate cytidylyltransferase

... (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction CTP + choline phosphate ... CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine ... choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline ... CDP-choline where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP ...

*PCYT1A

... phosphate cytidylyltransferase 1, choline, alpha". Hunt AN, Normand CS, Postle AD (1990). "CTP:cholinephosphate ... "Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding ... Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene. GRCh38: Ensembl release 89 ... 2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. 4: ...

*PCYT1B

Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene. GRCh38: Ensembl release 89 ... "Entrez Gene: PCYT1B phosphate cytidylyltransferase 1, choline, beta". Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The ... Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. ... phosphocholine cytidylyltransferase". J Biol Chem. 273 (22): 14022-9. doi:10.1074/jbc.273.22.14022. PMID 9593753. " ...

*Phosphatidylethanolamine N-methyltransferase

Sp1 is a negative regulator of PEMT transcription, yet is it is a positive regulator of choline-phosphate cytidylyltransferase ... While the CDP-choline pathway, in which choline obtained either by dietary consumption or by metabolism of choline-containing ... PC made via the PEMT pathway can be degraded by phospholipases C/D, resulting in the de novo formation of choline. Thus, the ... This is one of several examples of the reciprocal regulation of PEMT and CT in the PEMT and CDP-choline pathways. Estrogen has ...

*Citicoline

1-alkenyl-2-acylglycerol choline phosphotransferase Ceramide cholinephosphotransferase Choline-phosphate cytidylyltransferase ... Wurtman RJ, Regan M, Ulus I, Yu L (Oct 2000). "Effect of oral CDP-choline on plasma choline and uridine levels in humans". ... This limits the amount of choline available to synthesize phosphatidylcholine. When the availability of choline is low or the ... Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate ...

*3q29 microdeletion syndrome

These include transferrin receptor, choline-phosphate cytidylyltransferase A, RNF168, serine/threonine-protein kinase, nuclear ...

*X chromosome

... encoding enzyme Choline-phosphate cytidylyltransferase B PIN4: encoding enzyme Peptidyl-prolyl cis-trans isomerase NIMA- ...

*List of MeSH codes (D08)

... n-acylneuraminate cytidylyltransferase MeSH D08.811.913.696.445.184 --- choline-phosphate cytidylyltransferase MeSH D08.811. ... glucose-6-phosphate isomerase MeSH D08.811.399.475.200.550 --- mannose-6-phosphate isomerase MeSH D08.811.399.475.200.662 --- ... UTP-glucose-1-phosphate uridylyltransferase MeSH D08.811.913.696.445.900 --- UTP-hexose-1-phosphate uridylyltransferase MeSH ... nucleoside-phosphate kinase MeSH D08.811.913.696.900 --- transferases (other substituted phosphate groups) MeSH D08.811.913.696 ...

*List of EC numbers (EC 2)

... ethanolamine-phosphate cytidylyltransferase EC 2.7.7.15: choline-phosphate cytidylyltransferase EC 2.7.7.16: now EC 3.1.27.5 EC ... glucose-1-phosphate cytidylyltransferase EC 2.7.7.34: glucose-1-phosphate guanylyltransferase EC 2.7.7.35: ribose-5-phosphate ... glycerol-3-phosphate cytidylyltransferase EC 2.7.7.40: D-ribitol-5-phosphate cytidylyltransferase EC 2.7.7.41: phosphatidate ... isopentenyl phosphate kinase EC 2.7.4.27: (pyruvate, phosphate dikinase)-phosphate phosphotransferase EC 2.7.4.28: (pyruvate, ...
Administration of dexamethasone to pregnant rats at 19 days gestation increased phosphatidylcholine synthesis (45%) from radioactive choline in type II cells. This enhanced synthesis of phosphatidylcholine was accompanied by an increased conversion of choline phosphate into CDP-choline. Similar results were obtained by incubating organotypic cultures of 19-day-fetal rat lung with cortisol. The increased conversion of choline phosphate into CDP-choline correlated with an enhanced choline-phosphate cytidylyltransferase activity (31% after dexamethasone treatment; 47% after cortisol exposure) in the cell homogenates. A similar increase (26% after dexamethasone treatment; 39% after cortisol exposure) was found in the microsomal-associated enzyme. No differences in cytosolic enzyme activity were observed. The specific activity of the microsomal enzyme was 3-4 times that of the cytosolic enzyme. Most of the enzyme activity was located in the microsomal fraction (58-65%). The treatments had no effect ...
The cytidylyltransferases are a family of enzymes that utilize cytidine 5â?? triphosphate (CTP) to synthesize molecules that are precursors to membrane phospholipids. There are four well known enzymes: CTP: phosphoethanolamine cytidylyltransferase (ECT), CTP: glycerol-3-phosphate cytidylyltransferase (GCT), 2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase synthetase (CMS), and CTP: phosphocholine cytidylyltransferase (CCT). Previously, a radioisotope tagging method was employed to study cytidylyltransferase catalysis. Using CCT as a model, a method utilizing high performance liquid chromatography (HPLC) was developed to replace the radioisotope scintillation technique. The development of this new HPLC method is cheaper, more efficient, and more accurate than the previously established method. The targets of separation are the substrate CTP and the product cytidine diphosphate-choline (CDP-choline) of the reaction catalyzed by CCT. A solvent system based on previous literature which separated
Nuclear localization of enzymatically active green fluorescent protein-CTP: phosphocholine cytidylyltransferase fusion protein is independent of cell cycle conditions and cell types
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PtdCho is a major component of eukaryotic but not prokaryotic membranes. We demonstrate for the first time that a bacterium can inhibit the de novo synthesis of PtdCho in human cells. Significantly, this inhibition triggers apoptosis. Although inhibition of PtdCho biosynthesis initiates apoptosis in cells exposed to xenobiotics (13-15, 17, 28), in mutant cells with genetic CCT dysfunction (40), or in nutritional choline deprivation (18, 31), the response of human cells to pneumococcus is the first case where this mechanism plays a critical role in pathogenesis.. In the brain, PtdCho has an additional role as a precursor for the biosynthesis of the important neurotransmitter acetylcholine. It is unlikely that acetylcholine deprivation accounts for the observed pneumococcal-induced neuronal cell death because a low level of acetylcholine is not known to be a death signal and PtdCho serves as a reservoir of choline for acetylcholine biosynthesis under conditions of nutritional choline deprivation ...
The thousands of such receptors throughout the body play a fundamental role in the mechanisms of sight, smell and taste, and in regulating heart rate, blood pressure and glucose metabolism. The receptors are by far the most common target for drugs that affect cardiac output, blood pressure and many other physiological functions. Thus, said the researchers, their fundamental discovery could guide pharmaceutical companies in creating a new class of drugs that aim not at blocking the receptors themselves, but at modulating the machinery that regulates them. Such drugs could treat a range of disorders from congestive heart failure to Parkinsons disease, they said ...
Glucocorticoids appear to play an integral role in stimulating surfactant synthesis by activating the rate-regulatory enzyme for phosphatidylcholine synthesis, CTP:cholinephosphate cytidylyltransferase (CT). The activity of liver CT, in vitro, has been shown to be inhibited by the sphingomyelin hydrolysis product, sphingosine. In order to investigate the mechanisms by which glucocorticoids alter CT activity, in vivo, we administered betamethasone (1 mg/kg intraperitoneally) sequentially to adult male rats for 5 days. Betamethasone increased CT activity 2-fold relative to control in whole lung. The hormone also increased membrane-bound activity, but did not affect cytosolic enzyme activity. Betamethasone modestly increased CT mRNA as determined by the reverse-transcription PCR and Southern analysis of PCR products, but did not alter the levels of immunoreactive enzyme in lung membranes as demonstrated by Western blotting. The hormone did, however, produce a nearly 3-fold increase in ...
Looking for online definition of phosphatidylethanolamine cytidylyltransferase in the Medical Dictionary? phosphatidylethanolamine cytidylyltransferase explanation free. What is phosphatidylethanolamine cytidylyltransferase? Meaning of phosphatidylethanolamine cytidylyltransferase medical term. What does phosphatidylethanolamine cytidylyltransferase mean?
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 3oam: Crystal Structure of Cytidylyltransferase From Vibrio Cholerae
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Linakis, J. G., Bromberg, J. R., Casper, T. C., Chun, T. H., Mello, M. J., Richards, R., Mull, C. C., Shenoi, R. P., Vance, C., Ahmad, F., Bajaj, L., Brown, K. M., Chernick, L. S., Cohen, D. M., Fein, J., Horeczko, T., Levas, M. N., McAninch, B., Monuteaux, M. C., Grupp-Phelan, J. & 5 others, Powell, E. C., Rogers, A., Suffoletto, B., Dean, J. M. & Spirito, A., Mar 1 2019, In : Pediatrics. 143, 3, e20182001.. Research output: Contribution to journal › Article ...
Visit Healthgrades for information on Dr. Stacey Vance, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
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Annie Kennedy Meet my friend, Vance. Vance is a 30-something man, a "people person," husband, father, homeowner, accomplished professional with multiple degrees from prestigious universities, and valued community member, friend and employee. ...
Vance was the shows first openly gay female cast member. She appeared during the 11th season from 1985-86. Vance died of breast cancer in 1994. She was 40.
The ability of FtsY to be allosterically regulated by interaction with phospholipids suggests a simple and effective mechanism to spatially regulate protein targeting. The population of free FtsY molecules that are localized to the membrane (Fig. 9 B, step 1) would be pre-organized into the closed/activated conformations and thus more efficient at forming a stable, GTP-dependent SRP-FtsY complex (Fig. 9 B, step 2). This is consistent with the result from a recent study that suggested that membrane-bound FtsY is more efficient at targeting cargo-bound SRP to the membrane (Mircheva et al., 2009), and provides a molecular basis to explain this observation. However, the population of free FtsY molecules in the cytosol exist primarily in the open conformation, in which it quickly forms an early targeting intermediate with cargo-bound SRP (Fig. 9 B, step 3), but the equilibrium for rearrangement of the cargo-SRP-FtsY complex to the closed and activated states is not favorable in the cytosol (Zhang et ...
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Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
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Dr. Estil A. Vance III specializes in blood and marrow transplantation at Texas Oncolgy and is an expert in the field of oncology-related infections.
Well needless to say Vance eventually got a few things out of him and confronted Candace who then had what amounted to another breakdown. Candace went into a residential program for almost a month and when she came out they all went into family counseling. Vance and Candace also went into marriage counseling because Vance was just about ready to leave her at that point for what shed almost caused Cliff to do. Everything got mostly ironed out but you cant take back things like that; they affect you and change you. Cliff is different from his brothers but there are reasons for it. Candace tries but her chemistry and hormones got just too messed up and shes going to be on medication for the rest of her life. She has her good days and her bad ones and a couple of months ago the doctors had to start weaning her off the meds that had worked the best for her and trying other things because of all of the regulations that are changing what can be prescribed and to whom. Cliff … well hes a good boy ...
CHKA - CHKA (untagged)-Human choline kinase alpha (CHKA), transcript variant 1 available for purchase from OriGene - Your Gene Company.
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November 13, 1944 - April 15, 2010. In loving memory of John Vance Carter, of Santa Barbara, who passed away on Thursday, April 15, 2010. Vance Carter was born to Charles ("Nick") and Katherine (Mayer) Carter in Los Angeles, CA, on November 13, 1944. Vance attended Beverly Hills Catholic grammar school. He also attended Woodside Priory in Woodside, CA and graduated from Beverly Hills High School. He attended Foothill College and received his BA from the University of Denver in 1971.. He met his wife Georgine while attending DU and they were married in 1972. Vance became a Chef at Ernies Restaurant in San Francisco in 1971. Later he was the Head Chef at the Duchin Room at the Sun Valley Lodge in Idaho. He opened the Copper Basin Restaurant in Hailey ID in the 80s. He worked for Power Engineers in the 90s, and later created Yummy Foods, Inc. aka Georgines Naturals line of salad dressings.. Vance and Georgine moved to Santa Barbara in 2004 where he worked at the Sandpiper Golf Course and then ...
Courtney B. Vance Celebrity Profile - Check out the latest Courtney B. Vance photo gallery, biography, pics, pictures, interviews, news, forums and blogs at Rotten Tomatoes!
Someday Ill wish upon a star... Our Acid Rainbow iPhone 7 Plus cover is created with an image of sodium citrate (a common food additive) captured with polarized optical microscopy. The perfect science gift for rainbow lovers! Created by Assistant Professor Vance Williams from Simon Fraser University (Canada). Vance?s research ...
Buy Dricoril CD 2 mg/325 mg/5 mg Tablet - strip of 10 tablets at online at 1mg.com. Know the uses, side effects, price, composition, substitutes, How it works, Precautions and Expert Advice for Dricoril CD 2 mg/325 mg/5 mg Tablet manufactured by Vance Health Pharmaceuticals Ltd
FAA aeronautical and local business information for airport Vance Field (TE76), TX, US, covering airport operations, communications, weather, runways, comments and remarks, approach plates and procedures, services, all reporting businesses and FBOs, and kneeboard print outs.
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It might have been better-tactically better-to break with Johnson," he conceded later. "But it would have destroyed the Paris peace negotiations. I couldnt do that. I was Vice President. I was obliged to be a member of the team. I consulted with Averell Harriman on September 14 [1968] and urged that he and Cy Vance [Harriman and Cyrus Vance were the U.S. negotiators] agree to a withdrawal of U.S. troops. Harriman was upset. Vance was upset. Johnson was upset." Two of Humphreys ablest advisers, Ted Van Dyk and campaign manager Larry OBrien, told him never mind-he had to turn his back on a policy that no longer had general support and which, moreover, he knew was wrong. It had placed Johnsons chances for renomination in peril, rendered his re-election virtually impossible, and dissuaded him even from running. But despite a partial break, following which his standing in the polls soared, it was not in Humphreys nature to abandon Johnson completely. He stayed aboard the sinking Johnson ship too ...
The findings support a new hypothesis about how the innate immune system distinguishes pathogenic from non-pathogenic microbes, proposed by Portnoy, UC Berkeley colleague Russell Vance, assistant professor of molecular and cell biology, and Ralph Isberg of Tufts University in the July 23 issue of the journal Cell Host & Microbe. They argue that its not only how a pathogen looks that determines how the immune system responds, but also how it acts - where it goes in the cell, what pathways it interferes with, and how disruptive it is.. "There are a series of different things that pathogens have to do in order to be pathogenic, so it makes sense for the immune system to try to detect these common patterns," Vance said. "We know already that there are surveillance pathways in the cytosol that seem to respond specifically to pathogens and not to non-pathogens.". The findings are most important for creating effective vaccines against pathogens - bacteria, parasites and viruses - that live and hide ...
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This "Cited by" count includes citations to the following articles in Scholar. The ones marked * may be different from the article in the profile ...
Fosfatidat citidililtransferaza (EC 2.7.7.41, CDP digliceridna pirofosforilaza, CDP-diacilglicerolna sintaza, CDP-diacilgliceridna sintetaza, citidin difosfogliceridna pirofosforilaza, fosfatidat citidiltransferaza, fosfatidinsko kiselinska citidililtransferaza, CTP:1,2-diacilglicerofosfat-citidil transferaza, CTP-diacilglicerol sintetaza, DAG sintetaza, CDP-DG) je enzim sa sistematskim imenom CTP:fosfatidat citidililtransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju. ...
250 µCi quantities of [1-14C]-Oleic Acid are available for your research. Application of [14C]Oleic Acid can be found in: trans-10, cis-12 conjugated linoleic acid decreasing de novo lipid synthesis in human adipocytes, effect of dietary phosphatidylcholine on the assimilation and distribution of ingested free oleic acid in aquaculture, variation of liver-type fatty acid binding protein content in the human HepG2 affecting the rate of fatty acid uptake, oleic acid stimulating rapid translocation of cholinephosphate cytidylyltransferase in type II cells, intestinal-fatty acid binding protein (I-FABP) and lipid transport in human intestinal epithelial cells, etc. ...
ID A0A0F6BHP0_GEOS0 Unreviewed; 228 AA. AC A0A0F6BHP0; DT 24-JUN-2015, integrated into UniProtKB/TrEMBL. DT 24-JUN-2015, sequence version 1. DT 11-DEC-2019, entry version 30. DE RecName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase {ECO:0000256,HAMAP-Rule:MF_00108}; DE EC=2.7.7.60 {ECO:0000256,HAMAP-Rule:MF_00108}; DE AltName: Full=4-diphosphocytidyl-2C-methyl-D-erythritol synthase {ECO:0000256,HAMAP-Rule:MF_00108}; DE AltName: Full=MEP cytidylyltransferase {ECO:0000256,HAMAP-Rule:MF_00108}; DE Short=MCT {ECO:0000256,HAMAP-Rule:MF_00108}; GN Name=ispD {ECO:0000256,HAMAP-Rule:MF_00108}; GN OrderedLocusNames=GY4MC1_0085 {ECO:0000313,EMBL:ADP72941.1}; OS Geobacillus sp. (strain Y4.1MC1). OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus; OC unclassified Geobacillus. OX NCBI_TaxID=581103 {ECO:0000313,EMBL:ADP72941.1}; RN [1] {ECO:0000313,EMBL:ADP72941.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Y4.1MC1 {ECO:0000313,EMBL:ADP72941.1}; RG US DOE ...
15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following R0-resection of liver metastases is 28-39%, but recurrence eventually occurs in up to 70%. To date, adjuvant chemotherapy has not improved clinical outcomes significantly. The primary objective of the ongoing LICC trial (L-BLP25 In Colorectal Cancer) is to determine whether L-BLP25, an active cancer immunotherapy, extends recurrence-free survival (RFS) time over placebo in colorectal cancer patients following R0/R1 resection of hepatic metastases. L-BLP25 targets MUC1 glycoprotein, which is highly expressed in hepatic metastases from colorectal cancer. In a phase IIB trial, L-BLP25 has shown acceptable tolerability and a trend towards longer survival in patients with stage IIIB locoregional NSCLC. This is a multinational, phase II, multicenter, randomized, double-blind, placebo-controlled trial
(Nov. 5) Hardly a week goes by these days without a new study or two or three updating the old saws about an apple a day and carrots and good peepers.Consumers are getting the message. But are they turning that knowledge into action?It seems they are, according to new Fresh Trends research commissioned by Vance Research Services, a division of Vance Publishing Corp., Lincolnshire, Ill., publisher of The Packer.
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Available for private insurance holders, recipients of childrens vaccination program, as well as children with no health insurance. These vaccinations are recommended and available, based on childs age and medical condition.. Please schedule a well-child check, today, to discuss optimal coverage.. ...
Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive ...
the nonn! uissouniari. . U8LISUEB CTKHt 1 ; THURSDAY . MORNING, P. L.KQST & J.T. DAY, - GALLATIN, MISSOURI. - SUBSCEIPTIUX PIUCE: S.L50 ;Pex Year, L lTHbLft in Ad vance. I .!?I5,,Ica"0,u, from tB parte cflie coantry re V...w d ont ,?u" rru f te anther n-j-t In vi: i";a?any the r.i.-. not nccoivA.-.ly for "i"oa. to protect ub fra jaiioinon. f TTOITXEY AT LAWVXOTaUY PUB, LTC, MXD:-aii.-I "ar Cair- Agent, VSVilatia, MissoirI. Will pra" in the -- Coorl3 of the 17tH .Tniluiil Cir.-ii. atnl rt. uuipii, io ou ous:nc33 eairudieu to nut lCai"C. Pari irn fltt.r,fiin oirpn tr if.nn a -id selling ileal Eutate. r Office With S. A. Riciuirdon, west side .r .tae Public .Square.: . 2-n51-tf m mi T YTT iir: M I iff M li 1 r : "1th e,h as to (s sour ip :i.- . ..- . .-I If -Si.. vok iVvY any an attempts to haiiilcidwn fho Ampricani1, llag, shoot lnni oxi ;thbJ spot j " GALLATIN, MISSOURI; TJIUBSDAY, OCTOBER 3. 1867. NO. 1, F. G. FVLTOX, VTTORXE1" at Lar, Notary Public a r n Raa! Eritf Azevt, Jamesport, ...
KB / BW / DB Fat Loss Workout. Then youll want to check out the FVT Coaching Club here.. Youll get access to every workout and coaching video Ive put together for the program … along with every workout I will create for it over the next 12 months.. Not to mention, youll get a copy of my "official" FVT meal plan, 5 Minute Fat Loss … 41 Quick n Easy Meal Ideas … the FVT Community Cookbook …. And youll even get access to our private Facebook group where you can ask me ANY question you want, at any time, about your workouts or nutrition.. Its like having ME as your personal coach for the next 12 months.. Get 12 months of full access to all my workouts here. And starting burning MORE fat in LESS time.. - Forest Vance, MS, RKC II. PS - The big difference between following a program that has been pre-written and coaching is the feedback and personalized tweaks you can get when youre doing a coaching program.. For example, if you were following a program oriented towards fat loss and ...
He represents our country and our nations freedom. Of course, we talk about this a lot during our school day, and hes kind of a hero for our children. We wanted them to be able to see one of their heroes come home," said Shelly Vance, Assistant Principal at ...
World tours with Ed Sheeran and a Rudimental feature spot are turning Foy Vance into a household name. But the Bangor-born songwriter is keeping his cool ahead of the biggest gig of his life ...
VANCE | A little over six months ago, Mercedes-Benz broke ground for a new logistics center. On Wednesday, the giant warehouse covering more than 900,000 square feet was dedicated.
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photo credit: Altus Photo Design Earlier this year, Lawrence Vance gave a speech at the Mises Institutes 2011 Austrian Scholars Conference titled
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Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine ...
Phosphatidylcholines (PC) are the most abundant phospholipids in mammalian cells, where they serve well-characterized structural roles, maintaining membrane integrity, facilitating lipoprotein assembly and serving as a surfactant in the lung. Over the past decade, seminal papers have been published that describe novel roles for specific PC species derived from both the cytidine diphosphate-choline (CDP-choline) and phosphatidylethanolamine N-methyltransferase (PEMT) pathways of PC synthesis; these roles include both nuclear receptor agonism and generating critical physiological pools of the omega 3 fatty acid, docosahexaenoic acid (DHA). In addition to these novel functions, complex interactions between PC and its substrate, choline, with growth and energetic status have emerged, following the observation that the mammalian target of rapamycin complex 1 (mTORC1) is a major regulator of PC synthesis through the CDP-choline pathway. Presented in this dissertation are the tests of our primary ...
Youre invited to come and sing in the sun on Lonsdale Quay! You do not need to read music or have any singing/musical experience! All ages welcome! Beginners to professionals! Well be singing and learning harmony parts to one song each Thursday evening until Aug 24. Songs include Exs & Ohs by Elle King, Lean On Me by Bill Withers, Riptide by Vance Joy, Cant Buy Me Love by The Beatles and Cecilia by Simon & Garfunkel!. It really is just turn up and sing! There are no auditions, no need to read music, were open to all levels of musical experience! You will be given lyric sheets and easy instruction. If you are worried about learning harmony parts, then you are welcome to just sing the melody (the tune of the song). The singing starts at 6.30 pm for an hour. Find us by the fountain on the plaza at Lonsdale Quay!. Suggested donation is $5.. Come and join in! Theres more about us at www.impromptumusic.ca. ...
Courtney B. Vance is set co-star in ABCs medical drama pilot Warriors, from writer Chris Keyser, Mandeville TV and ABC Studios. Inspired by the Walter Reed Military Medical Center, Warriors follow the best and brightest active-duty military doctors and nurses as they practice trailblazing medicine.
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008 ...
Allcosmeticsource.com Phosphatidylcholine 70%, 1KG/BAG [216]- INTRODUCTION What is Phosphatidylcholine? Phosphatidylcholine is an integral component of every cell in the human body. Consumed regularly as part of our normal diets, Phosphatidylcholine has also been proven safe and effective over decades of study as a therapeutic agent. Researched extensively by scientists, Phosphatidylcholine has been shown to play a vital role
As much as Vances book resonated with me, I had so much more going for me than he did. Yes, I had a father with alcoholism and a mother with depression. I grew up in a combined family with a lot of anger and dysfunction. My parents personal problems led to their not giving their children and step-children the attention they needed. Yet unlike Vance, I did have two parents who stayed married. We werent rich, but we werent poor, and I never had any worries about having my physical needs met. In spite of his alcoholism, my dad always held down a job and paid the bills. Another parallel I share with Vance is the experience of being the child who benefits from parents seeming to figure out, later in life, how to be better parents. (In Vances case it wasnt his parents, but his grandparents, who did so.) Perhaps it was because as the youngest, for the second half of my childhood I was the only one left at home. I got benefits my older siblings didnt. I was the one who was driven to piano ...
During a recent workshop, for example, Turregano featured the movie The Legend of Bagger Vance, the 2000 film about a golfer and his mystical caddy, Bagger Vance, played by Will Smith. "I asked one group in the audience to look at the relationship and how Bagger developed and built on it. Another group was asked to view how Bagger assessed the golfers ability, while a third group was asked to comment on the golfers challenges and how Bagger supported him through these challenges. This provided excellent commentary for discussion around themes of coaching and developing others ...
Perform reliable qPCR with Bio-Rads pre-validated PCYT1B primer pair, for the Rhesus Monkey genome. Designed for SYBR Green-based detection.
Author: Vance Dwight A, Year: 2009, Abstract: The story of aspirin is a fascinating story involving war, disease, an English vicar, scrolls from the remote past, industrial development, corporate intrigue, and many other intricate and interrelated stories. This article is an abridged version of the history of aspirin that should tweak the interest of pharmacists and anyone interested in a fascinating true-life account of one of the most widely used medications in history. This abridged account of the history of aspirin represents only the s
assemble my regiment, which was disposed as guard through the train, and move to the front as fast as possible to support my division. I immediately started with the rear-guard, assembled the regiment as I passed the train, and moved as rapidly as possible past troops and through the train, which was also moving forward to the front, a distance of eight or ten miles, and then moved to the right of the road diagonally toward the woods, and formed in line of battle at a point designated by Major Lieber of General Bankss staff. General Ransom then ordered bayonets to be fixed, and conducted the regiment forward into the woods to support a battery, and ordered a company thrown out to protect our right flank. Soon after, by order of Colonel Vance, an officer and twenty-five men were advanced as skirmishers. It was about three oclock when an order was received from General Ransom to pile up the knapsacks, advance through the woods and take a position at the edge of the field on the ...
Philadelphia Phillies pitcher Vance Worley was placed on the 15-day disabled list, retroactive to May 12, with right elbow inflammation.
Manayunks Eco-Arts Festival is back again this weekend, with Main Street again stuffed with arts vendors, music, kids activities, an eco-car show and general enviro-education in a festive format. - Vance Lehmkuhl, Philadelphia Daily News
PC synthesis is activated both in vivo and in vitro by some metal ions to which the corresponding PC synthase mutant is not hypersensitive. For example, both the expressed Arabidopsis enzyme in vitro and PC synthesis in vivo (P.B. Goldsbrough, unpublished data) are efficiently activated by Cu. However, the cad1-3 mutant is only slightly more sensitive to Cu than is the wild type. Similarly, Zn activates both the expressed S. pombe enzyme in vitro and PC synthesis in S. pombe in vivo (Grill et al., 1986), but the PC synthase-deficient mutant is not more sensitive to Zn than is the wild type. Although PC synthesis may be activated in vivo by particular metal ions, PCs may play little or no role in their detoxification. This may be due, for example, to inefficient sequestration to the vacuole and an inability to form stable complexes or to the operation of other more effective mechanisms for the detoxification of these metals. Together, these observations indicate that in vitro data on the relative ...
An exhibition of large-scale oil paintings by Kelli Vance. The photorealistic works in the show explore "psychologically thrilling themes from voyeurism to assumed identity. Her work is primarily driven by complex narratives surrounding socially constructed notions of femininity that romanticize alternative forms of beauty." ...
1,2-dioleoyl-sn-glycero-3-phosphocholine 4235-95-4 NMR spectrum, 1,2-dioleoyl-sn-glycero-3-phosphocholine H-NMR spectral analysis, 1,2-dioleoyl-sn-glycero-3-phosphocholine C-NMR spectral analysis ect.
CDP-choline stands for cytidine-5Í-diphosphate choline. This unique form of choline readily passes through the blood-brain barrier (BBB) directly into the brain tissue. Once past the blood-brain barrier, CDP-choline activates the synthesis of critical components in cell membranes, enhances cerebral energy metabolism and increases levels of various neurotransmitters.. Supplement ...
My pedicure was so needed! It felt so good! Anyways, we then hit a few stores that will never be seen in small towns such as Blanding. I previously had made a couple of appointments to see some homes for rent for Vance and I since we are moving in 3 1/2 weeks! Those were scheduled on sunday so my Mom and I then left at 6:30 a.m. for a 3 or 4 hour drive into Bisbee, Az. To make a long story short, I found us a cute little 2 bedroom 2 bath home in Bisbee! Im not to excited about the location but it puts Vance closer to work out in Douglas and about a 20 minute drive into Sierra Vista where we can do movies, dinner, mall, etc. We will be living in the middle of nowhere on the border and its gonna have to take some getting used too. (At least for me) I have to say that Im kind of proud of myself that I made such a big decision all by myself. Dont get me wrong, I was abselutely scared to death and wish like crazy Vance could have been there with me, but under the circumstances I dont think I did ...
Ph.D., Mathematics, Virginia Tech, Blacksburg, VA, August, 2006 M.S., Mathematics, Virginia Tech, Blacksburg, VA, December, 2001. M.N.R, Natural Resources, Virginia Tech, Blacksburg, VA, May, 2014. B.S., Mathematics, Bluefield College, Bluefield, VA, May, 2000. A.A.&S., Education, Southwest Virginia Community College, Richlands, VA, May, 1998. ...
DOE-ORP announced the selection of Brian Vance as the new manager. Vance has over 30 years of leadership experience with Westinghouse, AREVA, and as a career submarine officer in the Navy, most recently as part of CH2M Hill Plateau Remediation Co ...
49ers quarterback Colin Kaepernick ended the 49ers off-season program for veterans with a flourish, completing four passes of 15 yards or more. It ended the last day of mandatory minicamp for the team. Rookies still have one more week before they are dismissed until the start of training camp at the end of July.. "Colin has been on it all off-season," coach Jim Harbaugh said. "That period especially was outstanding.". Highlights of practice included an nice catch by rookie tight end Vance McDonald on a ball thrown behind him. He also caught a few seam routes. "We have to have more Vance McDonald birthdays," Harbaugh said. McDonald turned 23 on Thursday.. The downer of the day was the anterior cruciate tear by wide receiver Brandon Carswell, the wide receiver from Milipitas, who signed on Wednesday. Carswell sustained the injury moments after getting onto the field for his practice. Carswell, who went to USC, was on the Raiders practice squad last season.. It leaves a spot open for a wide ...
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Page contains details about carbon nanotube-embedded 1,2-dioleoyl-sn-glycero-3-phosphocholine . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). BAY-60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling. Phosphodiesterases (PDEs) are key regulatory enzymes of intracellular cAMP/cGMP levels. These second messengers play important regulatory roles in controlling steroidogenesis in the adrenal. Disruption of PDEs has been associated with a number of adrenal diseases
Where to Buy Phosphatidylcholine supplements and powder. Reviews of the Best Phosphatidylcholine capsules, liquids, or injctions and the lowest prices.
Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Ariel D. Quiroga, Abhijit Takawale, Edward A. Armstrong, Jerome Y. Yager, Zamaneh Kassiri, Richard Lehner, Dennis E. Vance, René L. Jacobs ...
Paul Domowitch will chat about the NFL draft and other Eagles topics on Friday from noon to 1 p.m. - Vance Lehmkuhl, Philadelphia Daily News
Vance adds that though this is a small study group even, the results are encouraging and that further studies about this type of intervention should include a
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INTERNATIONAL. Interventional radiology has been described as the surgery of the new millennium by Stanford Healthcare, offering less invasive procedures, more precise placement of catheters and, often, fewer complications for patients and higher throughput for healthcare facilities. Robotics is making this new area of medicine possible. Cary G. Vance, CEO of Hansen Medical Inc., tells The Life Sciences Report about disruptive advances in interventional radiology and Hansens own revolutionary robotic catheters. The Life Sciences Report: Robotic catheter developer Hansen Medical Inc. (HNSN:NASDAQ) is one of the pioneers of interventional radiology. How are robotic procedures helping new surgical approaches to emerge or providing alternatives to open surgeries?. Cary Vance: In key areas, intravascular robotics are leading the way to less invasive treatments of certain disease states. For example, robotic prostatic artery embolization is a possible treatment for benign prostatic hyperplasia (BPH) ...
RECAP: Vance Worley (0-4) struggled through another rough outing, getting tagged for six runs on 10 hits in less than five innings as Minnesota lost in Detroit on Tuesday, April 30. Worley is 0-7 in 10 starts since his last victory, Aug. 1 at Washington while the right-hander was with Philadelphia.. Prince Fielder, who gutted the Twins with a three-run homer in Mondays victory, bashed a two-run shot as part of a three-run Detroit fifth. Miguel Cabrera jumped on Worley early with a two-run, first-inning homer as the Tigers (15-10) won their fifth straight. Justin Verlander (3-2) needed 114 pitches to work seven innings but he struck out eight while scattering five hits as Detroits ace improved to 9-0 over his past 10 starts against Minnesota and 14-7 all time. MEANING: The Twins slipped below .500 (11-12), losing the first two of a season-longest, 10-game, 11-day trip that also will take them to Cleveland and Boston. And they still have to face Anibal Sanchez, who set a Detroit record with 17 ...
17. The findings demonstrate significant correlations between CT activity and estimates of pleasantness when two different stimulus parameters were varied, that is, the speed of an object moving over the skin surface 26 Å. Vallbo et al. Fig. 17 Dependence of psychoneural relation on temperature of moving touch stimuli. Lefthand plot shows CT response (n = 8) to an object moving over the receptive field at different speeds. Three different object temperatures are color coded: black-neutral, red-warm, and blue-cool. B) Delayed acceleration of impulse discharge started after about 10 s. (a, b) Originate from the same recording displayed on different time scales After-Discharge and Tickle Hypothesis Long-lasting after-discharge in thin mechanoreceptive afferents was originally described by Zotterman (1939) in the cat and led him to formulate the tickle hypothesis, that is, that an essential role of unmyelinated tactile afferents is to account for the ticklish sensation associated with light touch. ...
Some years after Gordon Freeman and other scientists accidentally opened a portal to a dimension of hostile aliens at the Black Mesa Research Facility, Freeman is awoken from stasis by the mysterious G-Man.[1][2] The portal attracted the attention of the Combine, a technologically superior multidimensional empire which conquered Earth in seven hours. The Combine have implemented a brutal police state by biologically assimilating humans and other species, and preventing humans from breeding via a "suppression field". The G-Man inserts Gordon into a train arriving at City 17, site of the Combine Citadel, where Dr. Wallace Breen, the former Black Mesa administrator who negotiated Earths surrender, governs as the Combines puppet ruler.[3]. After eluding Combine forces, Gordon joins resistance members including Barney Calhoun, a former Black Mesa security guard working undercover as a Combine police officer; Dr. Eli Vance, former Black Mesa scientist and leader of the resistance; Alyx Vance, Elis ...
Such a pretty background just had to be the focus of this card. But I craved some white space! I trimmed the bottom edge of my panel with a *coming soon* edge die. I decided to inlay my daisy and my sentiment and cut the pieces. The sentiment was inlaid perfectly flat, but I gently rounded the petals of the daisy to create some dimension ...
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Michael J. Palchak, James F. Holmes, Cheryl W. Vance, Rebecca E. Gelber, Bobbie A. Schauer, Mathew J. Harrison, Jason Willis-Shore, Sandra L. Wootton-Gorges, Robert W. Derlet, Nathan Kuppermann ...
New York Supreme and/or Appellate Courts Appellate Division, First Department,January 15, 2013,Steven Banks, The Legal Aid Society, New York (Lorca Morello of counsel), for appellant. Cyrus R. Vance, Jr., District Attorney, New York (Martin J. Foncello of counsel), for respondent.,THE PEOPLE OF THE STATE OF NEW YORK, RESPONDENT, v. KEVIN RIOS, DEFENDANT-APPELLANT.
Phosphatidylcholine powder and softgels are excellent for emulsifying fat, making it extremely valuable for liver health. It is ideal for supporting absorption
In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction CDP-choline + 1,2-diacylglycerol ⇌ {\displaystyle \rightleftharpoons } CMP + a phosphatidylcholine Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine. This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include: 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase, 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase, 1-alkyl-2-acetylglycerol cholinephosphotransferase, alkylacylglycerol choline phosphotransferase, alkylacylglycerol cholinephosphotransferase, CDP-choline diglyceride phosphotransferase, cholinephosphotransferase, CPT, cytidine diphosphocholine glyceride ...
Hexadecylphosphocholine (HePC, miltefosine) is an alkylphospholipid used clinically for the topical treatment of cancer and against leishmaniasis. The mechanism of action of HePC, not yet elucidated, involves its insertion into the plasma membrane, affecting lipid homeostasis. It has also been proposed that HePC directly affects lipid raft stability and function in cell membranes. The present work deals with two main questions in the understanding of the action of HePC: the bases for membrane selectivity and as a membrane perturbator agent. We explored the interaction of HePC with lipid monolayers and bilayer vesicles, combining monolayer penetration experiments, Brewster angle microscopy and differential scanning calorimetry. Several membrane compositions were tested to explore different rheological conditions, phase states and lateral structures. Additionally, the kinetics between the soluble and the membrane form of HePC was explored. Our results showed an increase in elasticity induced by ...
Been a HSV (HERPES SIMPLEX VIRUS) positive is just like been through hell but EVERYTHING IS POSSIBLE. So amazing and i want to testify of the good work done by DR idahosa a very strong and powerful herbal remedy. DR idahosa has proved science and scientists wrong for believing and thinking that there is no cure for HSV (HERPES SIMPLEX VIRUS) but to be sincere this GREAT MAN is so real and powerful. I never thought that this spell will work but this GREAT MAN has proved it to me and it has worked and still working perfectly. i was diagnosed of the deadly disease called HSV (HERPES SIMPLEX VIRUS) in 2015 January and i thought that is the end and there will be no hope. Speaking to anyone was always a problem because i was so worried and my nails was always itching me and always in the state of unrest in fact i thought it was over until one blessed day when i was searching for help here on the INTERNET, i came across a testimony about DR idahosa on how he helped a lady who was HSV positive. At first ...
Been a HSV (HERPES SIMPLEX VIRUS) positive is just like been through hell but EVERYTHING IS POSSIBLE. So amazing and i want to testify of the good work done by DR idahosa a very strong and powerful herbal remedy. DR idahosa has proved science and scientists wrong for believing and thinking that there is no cure for HSV (HERPES SIMPLEX VIRUS) but to be sincere this GREAT MAN is so real and powerful. I never thought that this spell will work but this GREAT MAN has proved it to me and it has worked and still working perfectly. i was diagnosed of the deadly disease called HSV (HERPES SIMPLEX VIRUS) in 2015 January and i thought that is the end and there will be no hope. Speaking to anyone was always a problem because i was so worried and my nails was always itching me and always in the state of unrest in fact i thought it was over until one blessed day when i was searching for help here on the INTERNET, i came across a testimony about DR idahosa on how he helped a lady who was HSV positive. At first ...
Episode One foregår lige efter hændelserne i Half-Life 2. Gordon Freeman bliver igen kontaktet i sin dvale af G-Man, men før G-Man kan nå at sige noget, dukker en gruppe lysene vortigaunter frem som fører Gordon bort og omringer G-Man, som med et lettere irriteret ansigtsudtryk blot siger: "Vi får at se." Samtidig bliver Alyx Vance reddet fra Citadelens eksploderende generator af en anden gruppe vortigaunter.. Et ukendt antal timer senere vågner Gordon i en bunke murbrokker, som DOG, Alyx godmodige robot, graver ham fri af, og han bliver genforenet med hende. De kontakter straks Eli Vance og Isaac Kleiner, som er i gang med at omgruppere oprørshæren et sted udenfor City 17. Eli og Kleiner fortæller dem at Citadelens reaktorkerne er ved at nedsmelte, og at eksplosionen vil tage City 17, hvor en del af oprørshæren sidder fast, med i købet. Alyx beslutter sig for at prøve at få kernen midlertidigt stabiliseret for at skaffe hende og Gordon mere tid til at flygte. Imens de udfører ...
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Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia Pathogenesis of Bacterial Infections Infections due to Resistant Gram Positive Organisms Tropical medicine/International Health
Determinants of Outcome in Patients with Staphylococcus aureus Bacteremia Pathogenesis of Bacterial Infections Infections due to Resistant Gram Positive Organisms Tropical medicine/International Health
Phosphatidylcholine is a phospholipid with a choline molecule attached and is the main form of choline found in food. Double Woods Phosphatidylcholine contains 210 x 1200 mg softgels. Click here to learn more.
The type II alveolar epithelial cell synthesizes and secretes pulmonary surfactant. Terbutaline enhances phospholipid release from adult and fetal type II cells. Our hypothesis is that the actin network of microfilaments regulates the secretory activ

Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells | Biochemical...Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells | Biochemical...

... increased conversion of choline phosphate into CDP-choline correlated with an enhanced choline-phosphate cytidylyltransferase ... Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells. M Post ... Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells ... Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells ...
more infohttp://www.biochemj.org/content/241/1/291

Choline-phosphate cytidylyltransferase A - DrugBankCholine-phosphate cytidylyltransferase A - DrugBank

Choline-phosphate cytidylyltransferase A. Details. Name. Choline-phosphate cytidylyltransferase A. Kind. protein. Organism. ... Choline-phosphate cytidylyltransferase A. P49585. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ... Choline. approved, nutraceutical. unknown. product of. Details. DB00709. Lamivudine. approved, investigational. unknown. ...
more infohttps://www.drugbank.ca/biodb/bio_entities/BE0000615

Choline-phosphate cytidylyltransferase - WikipediaCholine-phosphate cytidylyltransferase - Wikipedia

Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction CTP + choline phosphate ... CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine ... choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline ... CDP-choline where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP ...
more infohttps://en.wikipedia.org/wiki/Choline-phosphate_cytidylyltransferase

Choline phosphate cytidylyltransferase | definition of choline phosphate cytidylyltransferase by Medical dictionaryCholine phosphate cytidylyltransferase | definition of choline phosphate cytidylyltransferase by Medical dictionary

... choline phosphate cytidylyltransferase explanation free. What is choline phosphate cytidylyltransferase? Meaning of choline ... phosphate cytidylyltransferase medical term. What does choline phosphate cytidylyltransferase mean? ... Looking for online definition of choline phosphate cytidylyltransferase in the Medical Dictionary? ... choline phosphate cytidylyltransferase. cho·line phos·phate cy·ti·dy·lyl·trans·fer·ase. an enzyme that catalyzes a key step in ...
more infohttps://medical-dictionary.thefreedictionary.com/choline+phosphate+cytidylyltransferase

Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.

Choline / metabolism. Choline-Phosphate Cytidylyltransferase. Diglycerides / metabolism. Dogs. Kidney / cytology, drug effects ... 62-49-7/Choline; EC 2.7.7.-/Nucleotidyltransferases; EC 2.7.7.15/Choline-Phosphate Cytidylyltransferase ... Finally, we showed that the inhibitory effect of hexadecylphosphocholine on CTP:choline-phosphate cytidylyltransferase ... Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells ...
more infohttp://www.biomedsearch.com/nih/Hexadecylphosphocholine-inhibits-translocation-CTPcholine-phosphate/1313020.html

Choline-phosphate cytidylyltransferase ACholine-phosphate cytidylyltransferase A

This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. ...
more infohttps://pharos.nih.gov/idg/targets/P49585

Phosphate cytidylyltransferase 1 choline alpha (PCYT1A) - Molecular Target Profile - BioCentury - BCIQPhosphate cytidylyltransferase 1 choline alpha (PCYT1A) - Molecular Target Profile - BioCentury - BCIQ

Comprehensive view of all products targeting Phosphate cytidylyltransferase 1 choline alpha (PCYT1A). Includes lead product ... status Publication and contact information Endocrine/metabolic disease Lipodystrophy Phosphate cytidylyltransferase 1 choline-a ...
more infohttps://bciq.biocentury.com/targets/PCYT1A

Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (...Transcriptional development of phospholipid and lipoprotein metabolism in different intestinal regions of Atlantic salmon (...

choline-phosphate cytidylyltransferase. pcyt2. Ethanolamine-phosphate cytidylyltransferase. pemt. phosphatidylethanolamine ... Glycerol-3-phosphate (G-3-P) is first acylated by acyltransferases to phosphatidic acid (PtdOH), which can be transferred into ... For example, it is believed that choline kinase (CK) α enzyme is critical for PtdCho maintenance in most tissues in mammals, ... Effect of body size on growth, survival, and chemical-composition of Atlantic Salmon fed soy lecithin and choline. Prog Fish ...
more infohttps://link.springer.com/article/10.1186/s12864-018-4651-8

CPT1 - Cholinephosphotransferase 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) - CPT1 gene & proteinCPT1 - Cholinephosphotransferase 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - CPT1 gene & protein

The CDP-choline pathway only contributes to net PC synthesis if exogenous choline is present. In its absence, this pathway ... recycles choline from PC turnover and may contribute to maintaining the proper PC species composition. ... Catalyzes the final step in the CDP-choline route leading to phosphatidylcholin (PC). Preferentially uses CDP- ... Choline-phosphate cytidylyltransferase (PCT1). *Cholinephosphotransferase 1 (CPT1), Choline/ethanolaminephosphotransferase 1 ( ...
more infohttps://www.uniprot.org/uniprot/P17898

Phospholipids are synthesized in the G2/M phase of the cell cycle.Phospholipids are synthesized in the G2/M phase of the cell cycle.

EC 2.7.7.14/Ethanolamine-phosphate cytidylyltransferase; EC 2.7.7.15/Choline-Phosphate Cytidylyltransferase ... Choline-Phosphate Cytidylyltransferase / metabolism. Cricetinae. Cricetulus. G2 Phase / physiology. Humans. Kinetics. ... Radiolabeled choline and ethanolamine were rapidly incorporated into cells maintained at G2/M phase with nocodazole, and the ...
more infohttp://www.biomedsearch.com/nih/Phospholipids-are-synthesized-in-phase/17113814.html

SCOPe 2.07: Structural Classification of Proteins - extendedSCOPe 2.07: Structural Classification of Proteins - extended

Compound: Choline-phosphate cytidylyltransferase. Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]. Gene: PF3D7_ ... Compound: Choline-phosphate cytidylyltransferase. Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]. Gene: PF3D7_ ... Compound: Choline-phosphate cytidylyltransferase. Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]. Gene: PF3D7_ ... Compound: Choline-phosphate cytidylyltransferase. Species: Plasmodium falciparum (isolate 3D7) [TaxId:36329]. Gene: PF3D7_ ...
more infohttp://scop.berkeley.edu/pdb/code=4zcs

Choline - DrugBankCholine - DrugBank

Choline-phosphate cytidylyltransferase activity. Specific Function. Controls phosphatidylcholine synthesis.. Gene Name. PCYT1B ... cholines (CHEBI:15354) / Pesticides (C00114) / a small molecule (CHOLINE) Targets. Details1. Choline-phosphate ... Choline bitartrate (55 mg/1) + Choline bitartrate (55 mg/1) + Ascorbic acid (120 mg/1) + Ascorbic acid (120 mg/1) + Calcium ... Choline bitartrate (55 mg/1) + Choline bitartrate (55 mg/1) + Ascorbic acid (120 mg/1) + Ascorbic acid (120 mg/1) + Calcium ...
more infohttps://www.drugbank.ca/drugs/DB00122

mouse beta isoform CTP phosphocholine cytidylyltransferase
     Summary Report | CureHuntermouse beta isoform CTP phosphocholine cytidylyltransferase Summary Report | CureHunter

mouse beta isoform CTP phosphocholine cytidylyltransferase: a CCT protein with a unique amino acid terminus that arises from an ... Subscribe to New Research on mouse beta isoform CTP phosphocholine cytidylyltransferase a CCT protein with a unique amino acid ...
more infohttp://www.curehunter.com/public/keywordSummaryC476147.do

Human Metabolome Database: HMDB0001565 (Phosphorylcholine) Protein AssociationsHuman Metabolome Database: HMDB0001565 (Phosphorylcholine) Protein Associations

Choline-phosphate cytidylyltransferase B. Q9Y5K3 PCYT1B. Xp22.11. Enzyme. Not Available. HMDBP00755. Choline-phosphate ... Choline/ethanolamine kinase. Q9Y259 CHKB. 22q13.33. Enzyme. Not Available. HMDBP00778. Choline kinase alpha. P35790 CHKA. ... cytidylyltransferase A. P49585 PCYT1A. 3q29. Enzyme. Not Available. HMDBP00776. Sphingomyelin phosphodiesterase. P17405 SMPD1. ...
more infohttp://www.hmdb.ca/metabolites/HMDB0001565/metabolite_protein_links

Pcyt1b - ddPCR Probe - Digital PCR | PrimePCR | Bio-RadPcyt1b - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad

Choline-phosphate cytidylyltransferase B Aliases:. Not Available. RefSeq:. NM_173151. Ensembl:. ENSRNOG00000012358 ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/drnocpe5178691-primepcr-ddpcr-expression-probe-assay-pcyt1b-rat

Human Metabolome Database: Showing metabocard for PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (HMDB0007892)Human Metabolome Database: Showing metabocard for PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (HMDB0007892)

Choline-phosphate cytidylyltransferase B. General function:. Involved in catalytic activity. Specific function:. Controls ... Choline-phosphate cytidylyltransferase A. General function:. Involved in catalytic activity. Specific function:. Controls ... Phosphorylates choline and ethanolamine. Has higher activity with choline. Gene Name:. CHKA. Uniprot ID:. P35790 Molecular ... Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P ...
more infohttp://www.hmdb.ca/metabolites/HMDB07892

Microarray Analysis of Pneumococcal Gene Expression during Invasive Disease | Infection and ImmunityMicroarray Analysis of Pneumococcal Gene Expression during Invasive Disease | Infection and Immunity

... evidence for choline phosphate cytidylyltransferase activity. FEMS Microbiol. Lett. 143:279-284. ... Investigation of a choline phosphate synthesis pathway in Streptococcus pneumoniae: ... We observed enhanced expression in the blood of the operon encoding choline-binding protein G (CbpG) and choline-binding ... Role of novel choline binding proteins in virulence of Streptococcus pneumoniae. Infect. Immun. 68:5690-5695. ...
more infohttps://iai.asm.org/content/72/10/5582?ijkey=91e59a6a75f9f48a60f60bca0d6816fbd9b8c494&keytype2=tf_ipsecsha

X chromosome - wikidocX chromosome - wikidoc

PCYT1B: encoding enzyme Choline-phosphate cytidylyltransferase B. *PIN4: encoding enzyme Peptidyl-prolyl cis-trans isomerase ...
more infohttp://wikidoc.org/index.php/X_chromosome

nature.com searchnature.com search

Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major *Samrat Moitra ... Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor *Laura B. Sheard ... Rights & permissionsfor article Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in , ... Rights & permissionsfor article Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor . Opens in a new ...
more infohttps://www.nature.com/search?author=%22Fong-Fu%20Hsu%22&error=cookies_not_supported&code=14971adb-dca7-429b-a316-9e38bdb090e7

Biomarker ArticlesBiomarker Articles

Choline-phosphate cytidylyltransferase-α as a possible predictor of survival and response to cisplatin neoadjuvant chemotherapy ... The aim of this study was to test choline-phosphate cytidylyltransferase-α (CCT-α) protein as a biomarker for neoadjuvant ...
more infohttps://www.urotoday.com/tags/biomarker.html

Table of Contents - August 01, 1998, 26 (3) | Biochemical Society TransactionsTable of Contents - August 01, 1998, 26 (3) | Biochemical Society Transactions

S phase depletion of nuclear CTP:choline phosphate cytidylyltransferase Alan N Hum, Graham C Burdge, Sarah M Wright, Anthony D ... Cell proliferation and CTP:cholinephosphate cytidylyltransferase activity in higher plants EDWARD T. PARKIN, CAROLE E. ROLPH ... Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin Paul S. Brookes, Joanna Haley, Paul Cutler, Patrick ... Modulation of CTP:phosphocholine cytidylyltransferase by membrane torque tension George S. Attard, Wendy S. Smith, Richard H. ...
more infohttp://www.biochemsoctrans.org/content/26/3

Transferases-Creative EnzymesTransferases-Creative Enzymes

ProductNameCholine-Phosphate Cytidylyltransferase (Crude Enzyme). EC No.EC 2.7.7.15. CAS No.9026-34-0 ...
more infohttps://www.creative-enzymes.com/cate/Transferases_74.html

Recombinant Human PCYT1B cell lysate PCYT1B-1319HCL - Creative BioMartRecombinant Human PCYT1B cell lysate PCYT1B-1319HCL - Creative BioMart

... phosphate cytidylyltransferase 1, choline, beta; phosphate cytidylyltransferase 1, choline, beta isoform; choline-phosphate ... choline =>PC, organism-specific biosystem; Phosphatidylcholine (PC) biosynthesis, choline =, PC, conserved biosystem;. ... cytidylyltransferase B; CCT beta; CTB; CT B; CCT B; CCT-beta; phosphorylcholine transferase B; CTP:phosphocholine ...
more infohttps://www.creativebiomart.net/description_412161_318.htm

PCYT1B - PCR Primer Pair - SYBR | PrimePCR | Bio-RadPCYT1B - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad

Choline-phosphate cytidylyltransferase B; Choline-phosphate cytidylyltransferase B isoform 1; Uncharacterized protein ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/qmccced0013708-primepcr-sybr-green-assay-pcyt1b-rhesus-monkey

Glycerophospholipid Biosynthetic Pathway (Homo sapiens) - WikiPathwaysGlycerophospholipid Biosynthetic Pathway (Homo sapiens) - WikiPathways

Choline-phosphate cytidylyltransferase EC 2.7.7.15 GraphId=afec6 Type=Protein, ,Graphics CenterX=1755.7656306142562 ... Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14 GraphId=f92a3 Type=Protein, ,Graphics CenterX=844.4822019172773 ... Cytidine diphosphate choline (CDP-choline) GraphId=f5af4 Type=Metabolite, ,Graphics CenterX=1897.9580372291277 CenterY= ... some also contain phosphate groups. In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a ...
more infohttps://www.wikipathways.org/index.php?title=Pathway:WP2533&action=edit&oldid=70358
  • In its absence, this pathway recycles choline from PC turnover and may contribute to maintaining the proper PC species composition. (uniprot.org)
  • Catalyzes the final step in the CDP-choline route leading to phosphatidylcholin (PC). (uniprot.org)
  • In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. (hmdb.ca)