Choline Kinase
Cytidine Diphosphate Choline
Choline
Hemicholinium 3
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
Phosphatidylcholines
Phosphatidylinositol 3-Kinases
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Choline O-Acetyltransferase
MAP Kinase Signaling System
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Choline-Phosphate Cytidylyltransferase
Phosphotransferases
Protein Kinases
Protein-Serine-Threonine Kinases
Choline Deficiency
A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Ethanolamine
Cyclic AMP-Dependent Protein Kinases
Calcium-Calmodulin-Dependent Protein Kinases
A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)
Deanol
Thiocholine
src-Family Kinases
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
Biochemical Phenomena
Protein Kinase C
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Cardiotoxins
Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.
Isoenzymes
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Mitogen-Activated Protein Kinase 1
Phosphotransferases (Alcohol Group Acceptor)
Phosphorylation
Substrate Specificity
p21-Activated Kinases
Betaine
A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
Mitogen-Activated Protein Kinase Kinases
A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Diacylglycerol Cholinephosphotransferase
Amino Acid Sequence
Serine
Choline Dehydrogenase
Protein-Tyrosine Kinases
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
CDC2 Protein Kinase
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
Cyclin-Dependent Kinases
MAP Kinase Kinase Kinases
Saccharomyces cerevisiae
Base Sequence
eIF-2 Kinase
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Casein Kinase II
Casein Kinases
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
Phosphorylation and regulation of choline kinase from Saccharomyces cerevisiae by protein kinase A. (1/136)
The CKI1-encoded choline kinase (ATP:choline phosphotransferase, EC 2.7.1.32) from Saccharomyces cerevisiae was phosphorylated in vivo on multiple serine residues. Activation of protein kinase A activity in vivo resulted in a transient increase in the phosphorylation of choline kinase. This phosphorylation was accompanied by a stimulation in choline kinase activity. In vitro, protein kinase A phosphorylated choline kinase on a serine residue with a stoichiometry (0.44 mol of phosphate/mol of choline kinase) consistent with one phosphorylation site/choline kinase subunit. The major phosphopeptide derived from the enzyme phosphorylated in vitro by protein kinase A was common to one of the major phosphopeptides derived from the enzyme phosphorylated in vivo. Protein kinase A activity was dose- and time-dependent and dependent on the concentrations of ATP (Km 2.1 microM) and choline kinase (Km 0.12 microM). Phosphorylation of choline kinase with protein kinase A resulted in a stimulation (1.9-fold) in choline kinase activity whereas alkaline phosphatase treatment of choline kinase resulted in a 60% decrease in choline kinase activity. The mechanism of the protein kinase A-mediated stimulation in choline kinase activity involved an increase in the apparent Vmax values with respect to ATP (2.6-fold) and choline (2.7-fold). Overall, the results reported here were consistent with the conclusion that choline kinase was regulated by protein kinase A phosphorylation. (+info)In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery. (2/136)
Transformation by some oncogenes is associated with increased activity of choline kinase (ChoK), resulting in elevated constitutive levels of phosphorylcholine, a proposed second messenger required for DNA synthesis induced by growth factors. Here we describe the characterization of ChoK inhibitors with antiproliferative properties against human tumor-derived cell lines. The new molecules were tolerated in mice at doses that showed in vivo antitumor activity against human tumor xenografts derived from HT-29 and A431 cell lines implanted s.c. in nude mice. This first generation of inhibitors provides in vivo evidence that blockade of phosphorylcholine production is a valid strategy for the development of new anticancer agents, opening a new avenue for the development of antitumor drugs with a novel mechanism of action. (+info)Extracellular calcium stimulates DNA synthesis in synergism with zinc, insulin and insulin-like growth factor I in fibroblasts. (3/136)
In serum-starved mouse NIH 3T3 fibroblasts cultured in 1.8 mM Ca2+-containing medium, addition of 0.75-2 mM extra Ca2+ stimulated DNA synthesis in synergism with zinc (15-60 microM), insulin and insulin-like growth factor I. Extra Ca2+ stimulated phosphorylation/activation of p42/p44 mitogen-activated protein kinases by an initially (10 min) zinc-independent mechanism; however, insulin, and particularly zinc, significantly prolonged Ca2+-induced mitogen-activated protein kinase phosphorylation. In addition, extra Ca2+ activated p70 S6 kinase by a zinc-dependent mechanism and enhanced the stimulatory effect of zinc on choline kinase activity. Insulin and insulin-like growth factor I also commonly increased both p70 S6 kinase and choline kinase activities. In support of the role of the choline kinase product phosphocholine in the mediation of mitogenic Ca2+ effects, cotreatments with the choline kinase substrate choline (250 microM) and the choline kinase inhibitor hemicholinium-3 (2 mM) enhanced and inhibited, respectively, the combined stimulatory effect of extra Ca2+ (3.8 mM total) and zinc on DNA synthesis. In various human skin fibroblast lines, 1-2 mM extra Ca2+ also stimulated DNA synthesis in synergism with zinc and insulin. The results show that in various fibroblast cultures, high concentrations of extracellular Ca2+ can collaborate with zinc and certain growth factors to stimulate DNA synthesis. Considering the high concentration of extracellular Ca2+ in the dermal layer, Ca2+ may promote fibroblast growth during wound healing in concert with zinc, insulin growth factor-I insulin, and perhaps other growth factors. (+info)Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta. (4/136)
Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products so far were all shown to have EK activity also, indicating that both activities reside on the same protein. CK/EK in most animal cells exists as several isoforms, for two of which (alpha and beta) their cDNAs have been cloned from both the rat and mouse, and they are found to be separate gene products. The physiological significance for the existence of more than one CK/EK enzyme, however, remains to be clarified. In this study, we isolated mouse genes encoding both types of CK/EK isozyme and determined their entire structure. The 5'-flanking promoter regions were found to have quite different features from each other, indicating that their expression could be under distinct control. Comparison of the nucleotide sequence between the corresponding coding exons showed the best homology (75%) residing on exon VIII. A search of the database resulted in the possible existence of 17 different origins of eukaryotic CK and/or EK, each of which presumably contained the entire amino acid sequence. Multialignment of their putative amino acid sequences led to an identification of the novel consensus sequence possibly required for the expression of either CK or EK activity, which corresponded to the sequence within exons VII and VIII of CK/EK-alpha and -beta genes from the mouse. This sequence was localized in close proximity to the C-terminal region of the general (Brenner's) phosphotransferase concensus sequence which was also completely conserved in all of the putative eukaryotic CK/EK proteins. The results demonstrated that, while both CK/EK-alpha and -beta genes were composed of 11 major exons, the size of their genes was quite different: 40 kb for CK/EK-alpha, whereas it was only 3.5 kb for CK/EK-beta. (+info)Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I. (5/136)
For characterization of the detailed gene structure of human muscle type carnitine palmitoyltransferase I (M-CPTI), we analyzed the 5'-upstream region of the M-CPTI transcripts. As a result, we found a cDNA clone containing a nucleotide sequence unexpected from the reported M-CPTI gene structure in the upstream region of its 5' end. Comparison of this nucleotide sequence with that of genomic DNA showed that this sequence was derived from the 3'-untranslated region of the gene encoding choline/ethanolamine kinase-beta (CK/EK-beta) located upstream of the M-CPTI gene. Southern blot analysis showed that there was no other region homologous to the CK/EK-beta gene in the whole human genome. Thus, the overlapping transcript was concluded to be produced from the functional genes of CK/EK-beta and M-CPTI. Furthermore, cDNAs containing both exons of these genes were detected by the polymerase chain reaction using the cDNA of human heart M-CPTI obtained by specific reverse transcription from its 3'-untranslated region as a template. From these results, the production and organization of these overlapping transcripts are discussed. (+info)Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. (6/136)
De novo production of phosphatidic acid (PA) in tumor cells is required for phospholipid biosynthesis and growth of tumor cells. In addition, PA production by phospholipase D has been cited among the effects of certain oncogenes and growth factors. In this report, it has been demonstrated that enhanced phospholipid metabolism through PA in tumor cells can be exploited pharmacologically for development of anticancer agents, such as CT-2584, a cancer chemotherapeutic drug candidate currently in Phase II clinical trials. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo phospholipid biosynthesis via PA to be shunted away from phosphatidylcholine (PC) and into phosphatidylinositol (PI), the latter of which was doubled in a variety of CT-2584-treated tumor cell lines. In contrast, cytotoxic concentrations of cisplatin did not induce accumulation of PI, indicating that PI elevation by CT-2584 was not a general consequence of chemotherapy-induced cell death. Consistent with this mechanism of action, propranolol, an inhibitor of PA phosphohydrolase and phosphatidylcholine biosynthesis, was also cytotoxic to tumor cell lines, induced PI accumulation, and potentiated the activity of CT-2584 in cytotoxicity assays. As expected from biophysical properties of anionic phospholipids on cellular membranes, CT-2584 cytotoxicity was associated with disruption and swelling of endoplasmic reticulum and mitochondria. We conclude that CT-2584 effects a novel mechanism of cytotoxicity to cancer cells, involving a specific modulation of phospholipid metabolism. (+info)Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity. (7/136)
Hexadecylphosphorylcholine (HePC, D-18506, INN: Mitelfosine) belongs to the family of alkylphosphocholines with anticancer activity. Previous reports have related its antitumoral activity to their ability to interfere with phospholipid metabolism. However a clear mechanism of action has not been established yet. We have investigated the effect of HePC on two enzymes recently reported to play a role in cell growth proliferation, phospholipase D (PLD) and choline kinase (ChoK). Our results demonstrate that treatment with HePC induces a rapid stimulation of PLD, that may be achieved by PKC dependent or independent mechanisms, depending on the cell line investigated. Both PLD1 and PLD2 isoenzymes are sensitive to HePC activation. By contrast, no effect was observed by HePC on ChoK, a new target for anticancer drug development. Furthermore, in all cell lines tested, a chronic exposure of the cells to HePC abrogates PLD activation by either phorbol esters or HePC itself with no effect on total cellular PLD levels. This is reflected in a strong inhibition of PLD activity. We suggest that the inhibitory effects on PLD by HePC may be related to its antitumoral action. (+info)Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. (8/136)
Ras proteins are molecular switches that control signaling pathways critical in the onset of a variety of human cancers. The signaling pathways activated by Ras proteins are those controlled by its direct effectors such as the serine-threonine protein kinase Raf-1, the exchange factor for other GTPases Ral-GDS, and the lipid kinase PI3K. As a consequence of Ras activation, a number of additional enzymes are affected, including several members of the serine-threonine intracellular proteins kinases as well as enzymes related to phospholipid metabolism regulation such as phospholipases A2 and D, and choline kinase. The precise mechanisms by which ras oncogenes impinge into these later molecules and their relevance to the onset of the carcinogenic process is still not fully understood. Here we have investigated the mechanism of regulation of choline kinase by Ras proteins and found no direct link between PLD and choline kinase activation. We provide evidence that Ras proteins regulate the activity of choline kinase through its direct effectors Ral-GDS and PI3K, while the Raf pathways seems to be not relevant in this process. The importance of Ras-dependent activation of choline kinase is discussed. (+info)
Choline/ethanolamine kinase
Choline kinase alpha (ChoK) overexpression is connected with an aggressive tumor | Epigenetic regulation of CpG promoter...
Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline...
OriGene - CHKA (NM 001277) cDNA Clone
Technology - Novel Choline Kinase inhibitors for cancer imaging and therapy
GFIT result for T01001
Choline kinase - Wikipedia
Publications - Professor Eric Aboagye
Product Overview anti-Choline Kinase alpha Antibodies
Plus it
choline kinase activity Gene Ontology Term (GO:0004103)
Choline Kinase beta antibody | acris-antibodies.com
N-[2-bromocinnamyl(amino)ethyl]-5-isoquinolinesulphonamide (H-89) inhibits incorporation of choline into phosphatidylcholine...
Choline Kinase
Summary Report | CureHunter
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Choline kinase family
Oh K! Chok Chok Undereye Mask | ASOS
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Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer |...
Gentaur Molecular :AbD \ GOAT ANTI HUMAN CHOLINE ACETYLTRANSFERASE, Product Type Polyclonal Antibody, Specificity CHOLINE...
Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 Gliomas and Correlation with 131I-SIP(L19), a Marker of Angiogenesis |...
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Choline
Potential Energy Fields about Nitrogen in Choline and Ethanolamine: Biological Function at Cellular Surfaces | Science
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Choline pharmaceutical drugs and health products
Choline pharmaceutical drugs and health products
Effects of choline on health across the life course: a systematic review
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Definition for choline
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Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target<...
Methods: Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline kinase alpha (CHKA) ... Methods: Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline kinase alpha (CHKA) ... Methods: Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline kinase alpha (CHKA) ... Methods: Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline kinase alpha (CHKA) ...
Choline Kinase | Profiles RNS
"Choline Kinase" by people in this website by year, and whether "Choline Kinase" was a major or minor topic of these ... "Choline Kinase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Choline Kinase" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Choline Kinase". ...
Choline Kinase | Profiles RNS
"Choline Kinase" by people in UAMS Profiles by year, and whether "Choline Kinase" was a major or minor topic of these ... "Choline Kinase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Choline Kinase" by people in Profiles over the past ten years. ... Below are MeSH descriptors whose meaning is more general than "Choline Kinase". ...
CHKA (Choline Kinase Alpha), rabbit, Polyclonal | Labstore
Choline Acetyltransferase Antibody
IMSEAR at SEARO: Purification of choline-ethanolamine kinase from chicken liver and its regulation by cAMP.
Nutrients | Free Full-Text | Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements
Adequate Intake (AI) recommendations for dietary choline (put forth by the National Academies of Medicine to aid individuals ... This review summarizes the genetic factors that influence choline requirements and metabolism in conditions of nutrient ... Overall, consistent and strong associative evidence demonstrates that common genetic variants in choline and folate pathway ... enzymes impact the metabolic handling of choline and the risk of nutrient inadequacy across varied dietary contexts. The ...
KEGG REACTION: R05647
thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase [EC:2.5.1.3 2.7.1.50]. K14156 choline/ethanolamine kinase [EC: ... L-serine kinase (ADP) [EC:2.7.1.226]. K23371 L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive ... uridine kinase [EC:2.7.1.48]. K00877 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase [EC:2.7.1.49 2.7.4.7 ... erythritol kinase (D-erythritol 1-phosphate-forming) [EC:2.7.1.215]. K00863 triose/dihydroxyacetone kinase / FAD-AMP lyase ( ...
Cytokeratin 5 Antibody (EP1601Y) (NB110-56916): Novus Biologicals
ALSF Childhood Cancer Research Grants | Page 2 | Alex's Lemonade Stand Foundation for Childhood Cancer
Pablo Domizi, Ph.D.'s Profile | Stanford Profiles
Choline kinase alpha expression during RA-induced neuronal differentiation: role of C/EBPβ. Biochimica et biophysica acta ... KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells. PloS one Domizi, P., Malizia, F ... Chka gene for choline kinase (CK) alpha isoform and Pcyt1a gene for CTP:phosphocholine cytidylyltransferase (CCT) alpha isoform ... the Chka gene for choline kinase (CK) alpha isoform and the Pcyt1a gene for the CTP:phosphocholine cytidylyltransferase (CCT) ...
Activitats archivos | Pàgina 56 de 63 | Fundació Dr. Antonio Esteve
Biophysics - BIFI - - Institute for Biocomputation and Physics of Complex Systems
23. Recent advances in the design of Choline kinase α inhibitors and the molecular basis of their inhibition. Belén Rubio-Ruiz ... Guadix and Dr Conejo-García from University of Granada in the development of new inhibitors against human choline kinase α1. ... 5.- The mechanism of allosteric coupling in choline kinase α1 revealed by a rationally designed inhibitor. María Sahún-Roncero ... 4.- Human riboflavin kinase: Species‐specific traits in the biosynthesis of the FMN cofactor. Ernesto Anoz‐Carbonell, Maribel ...
Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate...
... with choline tracers has found widespread use for the diagnosis of prostate cancer (PC). However, choline metabolism is ... whereas choline transport and choline kinase activity are high.. Although further analyses are needed to confirm these findings ... there was no relation between PSA and SUV values in both choline- and PSMA-based PET/CT in our study. With regard to choline, ... vertebral metastases are usually difficult to detect in choline PET (c). Typical for choline PET is also a frequently high ...
Radiopharmaceuticals in Preclinical and Clinical Development for Monitoring of Therapy with PET | Journal of Nuclear Medicine
11C-Choline PET. Given that the upregulation of choline kinase is often associated with cancer, a strong rationale exists for ... 11C-choline has been reported to be a new agent for PET of brain tumors and other cancers (166-168). In particular, 11C-choline ... Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma ... 11C-choline PET for the detection of bone and soft tissue tumours in comparison with FDG PET. Nucl Med Commun. 2003;24:273-279. ...
Andrew Welch - Research output
- The University of Aberdeen Research Portal
Methyl-3H]-choline incorporation into MCF-7 Cells: Correlation with Proliferation-Choline Kinase and Phospholipase D Assay. Al- ... methyl-3H]Choline incorporation into MCF7 tumour cells: correlation with proliferation. Al-Saeedi, F., Welch, A. & Smith, T. A ... F-18-FDG and C-11-choline positron emission tomography in human esophago-gastric cancer: prediction of response to therapy. ...
NIOSHTIC-2 Search Results - Full View
Molecular mechanism of the extended oil accumulation phase contributing to the high seed oil content for the genotype of tung...
... probable ethanolamine kinase; CK, probable choline kinase 2; PP, putative lipid phosphate phosphatase; LPP2, lipid phosphate ... Serine/threonine-protein kinase AFC2; LRR-RLK1, Probable LRR receptor-like serine/threonine-protein kinase; H2A.1, Probable ... The expression of plastid pyruvate kinase (PK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase, the genes encoding ... Plastidial pyruvate kinase 2 (PK2) and Putative glucose-6-phosphate 1-epimerase (PEG1-1) (Additional file 7: Figure S5). Thus, ...
Clinical Subtypes | cmdir.org
HOMD :: SEQF2779
choline/ethanolamine kinase%2C putative. 130. SEQF2779,CP000925.1. ABY79358.1 jb [NA] [AA] 894/297. 394931-394038. DNA ... uridylate kinase. 194. SEQF2779,CP000925.1. ABY79422.1 jb [NA] [AA] 987/328. 466790-465804. fatty acid/phospholipid synthesis ... phosphoglycerate kinase. 33. SEQF2779,CP000925.1. ABY79261.1 jb [NA] [AA] 369/122. 240001-240369. conserved hypothetical ... inorganic polyphosphate/ATP-NAD kinase%2C probable. 182. SEQF2779,CP000925.1. ABY79410.1 jb [NA] [AA] 4173/1390. 439020-434848 ...
Congenital Muscle Disease Study of Patient and Family Reported Medical Information - Full Text View - ClinicalTrials.gov
MMTB
choline + ATP <=> H+ + phosphocholine + ADP 2.7.1.32 choline kinase 2.7.1.82 ethanolamine kinase - - ... 2.7.1.107 diacylglycerol kinase (ATP) 2.7.1.138 ceramide kinase 2.7.1.94 acylglycerol kinase - - - ... choline + acetyl-CoA <=> Acetylcholine + CoA 2.3.1.6 choline O-acetyltransferase 2.3.1.7 carnitine O-acetyltransferase - - ... CTP + phosphocholine + H+ <=> CDP-choline + diphosphate 2.7.7.15 choline-phosphate cytidylyltransferase 2.7.7.57 N- ...
Caliper Assay Kinase - Diastrip Gentaur
Choline Kinase (ChoK) Activity Assay Kit (Fluorometric). K476-100 Biovision EUR 947 ... Caliper Assay Kinase. Lab Reagents Human IgG antibody Laboratories manufactures the caliper assay kinase reagents distributed ... please contact kinase assay. Other Caliper products are available in stock. Specificity: Caliper Category: Assay Group: Kinase ... The Caliper Assay Kinase reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these ...
Publikationen - Molekulare Parasitologie
GSE29618 PRE VS DAY7 POST TIV FLU VACCINE MONOCYTE DN
Code System Concept
DeCS
Choline kinase Descripteur en anglais: Choline Kinase Descripteur en espagnol: Colina Quinasa Espagnol dEspagne ... An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the ... phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can ...
Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen...
Choline kinase and Choline transport protein - catalyze phosphorylcholine attachment to carbohydrate, releasing CMP in ... death-associated protein kinase 1, protein kinase CK-2 and COX-2. This results in accumulation of oncogenic or inactivating ... However, host DNA repair mechanism unable to restore this damage as F. nucleatum induces the production of kinases involved in ... Lck and Fyn tyrosine kinases in initiation of TCR activation, viral myocarditis indicate the relevance of F. nucleatum ...
Phosphatidylcholine metabolism in neonatal mouse calvaria<...
Choline kinase activity in calvarial cytosol was lower than choline kinase activity in liver cytosol of the same animals. No ... Choline kinase activity in calvarial cytosol was lower than choline kinase activity in liver cytosol of the same animals. No ... Choline kinase activity in calvarial cytosol was lower than choline kinase activity in liver cytosol of the same animals. No ... Choline kinase activity in calvarial cytosol was lower than choline kinase activity in liver cytosol of the same animals. No ...
Congenital Muscular Dystrophy: Background, Pathophysiology, Epidemiology
CMD with mitochondrial structural abnormalities; Choline kinase beta. The OMIM classification of defects of glycosylation is as ... Serum creatine kinase (CK) is elevated in several cases but not all. Appropriate muscle biopsy studies are crucial for accurate ... dilated cardiomyopathy to successful cardiac transplantation in congenital disorders of glycosylation due to dolichol kinase ...