An enzyme that catalyzes the oxidation of cholesterol in the presence of molecular oxygen to 4-cholesten-3-one and hydrogen peroxide. The enzyme is not specific for cholesterol, but will also oxidize other 3-hydroxysteroids. EC 1.1.3.6.
Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.
An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.
Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.
An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.
Inability to empty the URINARY BLADDER with voiding (URINATION).
A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Oxidoreductases that are specific for the reduction of NITRATES.
Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclature, 1992) EC 1.
Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
An enzyme that utilizes NADH or NADPH to reduce FLAVINS. It is involved in a number of biological processes that require reduced flavin for their functions such as bacterial bioluminescence. Formerly listed as EC 1.6.8.1 and EC 1.5.1.29.
A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5
A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An NAD-dependent enzyme that catalyzes the oxidation of nitrite to nitrate. It is a FLAVOPROTEIN that contains IRON and MOLYBDENUM and is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. It was formerly classified as EC 1.6.6.1.
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
The rate dynamics in chemical or physical systems.
An enzyme of the oxidoreductase class that catalyzes the formation of 2'-deoxyribonucleotides from the corresponding ribonucleotides using NADPH as the ultimate electron donor. The deoxyribonucleoside diphosphates are used in DNA synthesis. (From Dorland, 27th ed) EC 1.17.4.1.
Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An enzyme that catalyzes the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine in the presence of NADP+. Defects in the enzyme are a cause of PHENYLKETONURIA II. Formerly listed as EC 1.6.99.7.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A subtype of thioredoxin reductase found primarily in the CYTOSOL.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Databases devoted to knowledge about specific genes and gene products.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.

Reversion of the differentiated phenotype and maturation block in Sertoli cells in pathological human testis. (1/92)

To study the relationship between abnormal Sertoli cell differentiation and spermatogenic impairment, we examined the expression of Sertoli cell markers normally lost at puberty, cytokeratin 18 (CK18), anti-Mullerian hormone (AMH) and M2A antigen, in three children (aged 1-2 years), 50 adults (aged 19-45 years) with obstructive or non-obstructive azoospermia or oligozoospermia, and six patients (aged 1-18 years) with 5 alpha-reductase deficiency. There was CK18 and/or AMH expression, but never M2A antigen expression, associated with spermatogonial arrest or Sertoli cell-only (SCO) syndrome in infertile men. Loss of M2A antigen suggests the transition of Sertoli cells to an adult phenotype, while CK18 and/or AMH expression may be a manifestation of de-differentiation of Sertoli cells. In 5 alpha-reductase deficiency, there was a sequential loss of CK18, M2A antigen and AMH around puberty, associated with partial spermatogenesis. The persistence of immature Sertoli cells expressing M2A antigen was associated with prepubertal seminiferous cords and SCO syndrome. Therefore, 5 alpha-reductase deficiency may prevent the maturation of Sertoli cells, resulting in impairment of spermatogenesis, and loss of M2A antigen expression coincides with a critical step in the Sertoli cell maturation. High follicle stimulating hormone concentrations due to failure of normal Sertoli cell differentiation indicate a normal development pattern of the hypothalamic-pituitary-gonadal axis.  (+info)

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. (2/92)

The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma-aminobutyric acid at gamma-aminobutyric acid type A receptors and hence is a powerful anxiolytic, anticonvulsant, and anesthetic agent. Allopregnanolone is synthesized from progesterone by reduction to 5alpha-dihydroprogesterone, mediated by 5alpha-reductase, and by reduction to allopregnanolone, mediated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Previous reports suggested that some selective serotonin reuptake inhibitors (SSRIs) could alter concentrations of allopregnanolone in human cerebral spinal fluid and in rat brain sections. We determined whether SSRIs directly altered the activities of either 5alpha-reductase or 3alpha-HSD, using an in vitro system containing purified recombinant proteins. Although rats appear to express a single 3alpha-HSD isoform, the human brain contains several isoforms of this enzyme, including a new isoform we cloned from human fetal brains. Our results indicate that the SSRIs fluoxetine, sertraline, and paroxetine decrease the K(m) of the conversion of 5alpha-dihydroprogesterone to allopregnanolone by human 3alpha-HSD type III 10- to 30-fold. Only sertraline inhibited the reverse oxidative reaction. SSRIs also affected conversions of androgens to 3alpha- and 3alpha, 17beta-reduced or -oxidized androgens mediated by 3alpha-HSD type II(Brain). Another antidepressant, imipramine, was without any effect on allopregnanolone or androstanediol production. The region-specific expression of 3alpha-HSD type II(Brain) and 3alpha-HSD type III mRNAs suggest that SSRIs will affect neurosteroid production in a region-specific manner. Our results may thus help explain the rapid alleviation of the anxiety and dysphoria associated with late luteal phase dysphoria disorder and major unipolar depression by these SSRIs.  (+info)

2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5alpha-dihydrotestosterone formation or testicular androgen production in rat offspring. (3/92)

In utero and lactational exposure to a single maternal dose of 1 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg causes some overt toxicity and impairs prostate growth in male offspring. As similar effects on the ventral prostate can be caused by decreased testosterone production during perinatal development, we determined whether intratesticular testosterone content, testicular responsiveness to gonadotropin stimulation, or plasma testosterone concentrations were reduced in fetal and newborn rats. Because these endpoints were not affected, the ability of TCDD exposure to inhibit synthesis of the proximal androgen in prostate development, 5alpha-dihydrotestosterone (DHT), from the circulating precursor testosterone and 5alpha-androstane-3alpha,17ss-diol (3alpha-Diol), was studied on postnatal days (PNDs) 14, 21, and 32. The ability of the ventral prostate to form DHT from 3alpha-Diol was slightly impaired on PND 14, but this transient effect was not statistically significant, and recovery was evident by PND 21. Subsequent experiments used organ culture to study the effects of in vivo TCDD exposure on androgen metabolism, androgen responsiveness, androgen receptor expression, and luminal epithelial cell differentiation after in vitro exposure to graded androgen concentrations. In utero and lactational TCDD exposure had no effect on DHT formation in organ culture, but transiently reduced the androgen -induced expression of prostatic-binding protein subunit C3, decreased ventral prostate epithelial cell androgen receptor expression, and inhibited the formation of androgen responsive luminal epithelial cells. These results suggest that TCDD exposure impairs prostate growth and androgen responsiveness by inhibiting prostatic epithelial cell differentiation.  (+info)

Sebocytes are the key regulators of androgen homeostasis in human skin. (4/92)

The mRNA expression patterns of the androgen receptor and the androgen metabolizing enzymes 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase, 17beta-hydroxysteroid dehydrogenase, 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase were investigated in three different cell populations originating from human skin, SZ95 sebocytes, HaCaT keratinocytes, and MeWo melanoma cells, by means of reverse transcription polymerase chain reaction. Restriction analysis of cDNA fragments was performed to identify isozymes of 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase and 3alpha-hydroxysteroid dehydrogenase. In addition, 3H-dihydroepiandrosterone and 3H-testosterone were used as substrates to determine the metabolic activity of these enzymes in SZ95 sebocytes, primary sebocyte cultures, and HaCaT keratinocytes. Furthermore, the effects of the selective 5alpha-reductase type 1 and 2 inhibitors, 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one and dihydrofinasteride, respectively, and of the 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase inhibitor cyproterone acetate on androgen metabolism were investigated. Androgen receptor mRNA was detected in SZ95 sebocytes and HaCaT keratinocytes but not in MeWo melanoma cells, whereas 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase isotype 1 mRNA and metabolic activity were only found in SZ95 sebocytes. The enzyme activity could be inhibited by cyproterone acetate. Type 2 17beta-hydroxysteroid dehydrogenase, type 1 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase mRNA were expressed in all three cell populations tested, whereas type 3 17beta-hydroxysteroid dehydrogenase mRNA could only be detected in SZ95 sebocytes. The major metabolic steps of testosterone in SZ95 sebocytes, primary sebocyte cultures, and HaCaT keratinocytes were its conversion to androstenedione by 17beta-hydroxysteroid dehydrogenase and further to 5alpha-androstanedione by 5alpha-reductase. The type 1 5alpha-reductase selective inhibitor 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one, but not the type 2 selective inhibitor dihydrofinasteride, inhibited 5alpha-reductase at low concentrations in SZ95 sebocytes and HaCaT keratinocytes. 5alpha-androstanedione was degraded to androsterone by 3alpha-hydroxysteroid dehydrogenase, which exhibited a stronger activity in HaCaT keratinocytes than in SZ95 sebocytes and in primary sebocyte cultures. Lower levels of 5alpha-dihydrotestosterone and 5alpha-androstanediol were also detected in all cells tested. Our investigations show that specific enzyme expression and activity in cultured sebocytes and keratinocytes seem to allocate different duties to these cells in vitro. Sebocytes are able to synthesize testosterone from adrenal precursors and to inactivate it in order to maintain androgen homeostasis, whereas keratinocytes are responsible for androgen degradation.  (+info)

Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. (5/92)

Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? and (b) Could a man reduce his activity level by modifying his lifestyle? To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. We also examined associations between these metabolite levels and such lifestyle characteristics as body size and physical activity as well as select aspects of medical history and family history of prostate cancer. Men included in this cross-sectional analysis (n = 1054) had served as control subjects in a population-based case-control study of prostate cancer we conducted in California, Hawaii, and Vancouver, Canada and provided information on certain personal attributes and donated blood between March 1990 and March 1992. In this study, concentrations of 3alpha-diol G declined significantly with age and increased significantly with body mass index. Mean levels of 3alpha-diol G, adjusted for age and body mass index, were 6.1 ng/ml in African-Americans, 6.9 ng/ml in whites and 4.8 ng/ml in Asian-Americans. These differences were statistically significant (African-Americans versus whites: P < 0.01; whites versus Asian-Americans: P < 0.001). Concentrations of AG decreased significantly with age, but only in whites, and were unrelated to any of the reported personal attributes. Mean levels of AG, adjusted for age, were 44.1 ng/ml in African-Americans, 44.9 ng/ml in whites, and 37.5 ng/ml in Asian-Americans (Asian-Americans versus whites, P < 0.001). In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. This difference may be related to the lower prostate cancer risk in Asian-Americans.  (+info)

Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. (6/92)

Nutritional factors, especially phytoestrogens, have been extensively studied for their potential beneficial effects against hormone-dependent and age-related diseases. The present study describes the short-term effects of dietary phytoestrogens on regulatory behaviors (food/water intake, locomotor activity and body weight), prostate weight, prostate 5alpha-reductase enzyme activity, reproductive hormone levels, and testicular steroidogenic acute regulatory peptide (StAR) levels in adult Sprague-Dawley rats. Animals were fed either a phytoestrogen-rich diet containing approximately 600 microg/g isoflavones (as determined by HPLC) or a phytoestrogen-free diet. After 5 weeks of consuming these diets, plasma phytoestrogen levels were 35 times higher in animals fed the phytoestrogen-rich vs phytoestrogen-free diets. Body and prostate weights were significantly decreased in animals fed the phytoestrogen-rich diet vs the phytoestrogen-free fed animals; however, no significant change in prostate 5alpha-reductase enzyme activity was observed between the treatment groups. Locomotor activity levels were higher in the phytoestrogen-rich vs the phytoestrogen-free animals during the course of the treatment interval. Plasma testosterone and androstenedione levels were significantly lower in the animals fed the phytoestrogen-rich diet compared with animals fed the phytoestrogen-free diet. However, there were no significant differences in plasma LH or estradiol levels between the diet groups. Testicular StAR levels were not significantly different between the phytoestrogen-rich vs the phytoestrogen-free fed animals. These results indicated that consumption of dietary phytoestrogens resulting in very high plasma isoflavone levels over a relatively short period can significantly alter body and prostate weight and plasma androgen hormone levels without affecting gonadotropin or testicular StAR levels. The findings of this study identify the biological actions of phytoestrogens on male reproductive endocrinology and provide insights into the protective effects these estrogen mimics exert in male reproductive disorders such as benign prostatic hyperplasia and prostate cancer.  (+info)

Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study. (7/92)

It has been suggested that the activity of the steroid 5alpha-reductase type II enzyme (encoded by the SRD5A2 gene) may be associated with prostate cancer risk and that population differences in this enzyme's activity may account for part of the substantial racial/ethnic disparity in prostate cancer risk. To provide etiological clues, we evaluated the relationships of four polymorphic markers in the SRD5A2 gene, specifically, A49T (a substitution of threonine for alanine at codon 49), V89L (a substitution of leucine for valine at codon 89), R227Q (a substitution of glutamine for arginine at codon 227), and a (TA)n dinucleotide repeat, with prostate cancer risk in a population-based case-control study in China, a population with the lowest reported prostate cancer incidence rate in the world. Genotypes of these four markers were determined from genomic DNA of 191 incident cases of prostate cancer and 304 healthy controls using PCR-based assays, and serum androgen levels were measured in relation to these genotypes. All study subjects had the wild-type AA genotype of the A49T marker, and 99% had the RR genotype of the R227Q marker. For the V89L marker, prevalences of the LL, VV, and VL genotypes among controls were 35%, 21%, and 45%, respectively. Compared with men with the VV genotype, those with the LL genotype had a statistically nonsignificant 12% reduced risk (odds ratio = 0.88, 95% confidence interval, 0.53-1.47). In addition, men with the LL genotype had significantly higher serum levels of testosterone and significantly lower serum levels of 5alpha-androstane-3alpha,17beta-diol glucuronide than men with other genotypes. Men heterozygous for the (TA)0 allele of the (TA)n marker had a modest, statistically nonsignificant risk reduction (odds ratio = 0.67; 95% confidence interval, 0.39-1.12) compared with men homozygous for the (TA)0 allele, along with significantly higher serum dihydrotestosterone levels. The observed V89L genotype prevalences and the association between V89L genotypes and serum androgen levels support the hypothesis that genotypes associated with lower levels of 5alpha-reductase activity are more common in low-risk populations. Although we found no statistically significant associations of these SRD5A2 polymorphisms with prostate cancer risk, a small effect of these markers cannot be ruled out because of the rarity of certain marker genotypes. Larger studies are needed to further clarify the role of these markers and to elucidate whether genetic diversity of the SRD5A2 gene, alone or in combination with other susceptibility genes, can help explain the large racial/ethnic differences in prostate cancer risk.  (+info)

Allelic frequencies of six polymorphic markers for risk of prostate cancer. (8/92)

The aim of the present study was to evaluate the distribution of polymorphisms for the androgen receptor (AR) (CAG, StuI, GGN), SRD5A2 (Ala49Thr, Val89Leu) and CYP17 (MspA1) genes that are considered to be relevant for risk of prostate cancer. We studied 200 individuals from two cities in the State of Sao Paulo, by PCR, PCR-RFLP and ASOH techniques. The allelic frequencies of the autosomal markers and the StuI polymorphism of the AR gene were very similar to those described in most North American and European populations. In relation to the CAG and GGN number of repeats, the study subjects had smaller repeat lengths (mean of 20.65 and 22.38, respectively) than those described in North American, European and Chinese populations. In the present study, 30.5% of the individuals had less than 22 CAG repeats and 45.5% had less than 23 GGN repeats. When both repeat lengths are considered jointly, this Brazilian population is remarkably different from the others. Further studies on prostate cancer patients need to be conducted to assess the significance of these markers in the Brazilian population.  (+info)

The IUPHAR/BPS Guide to Pharmacology. steroid 5 alpha-reductase 2 - 1.-.-.- Oxidoreductases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
Changes in the voice are almost always indicative of a medical problem; patients experiencing hoarseness or other voice changes should see a physician to determine the cause
Looking for online definition of 5-alpha-reductase in the Medical Dictionary? 5-alpha-reductase explanation free. What is 5-alpha-reductase? Meaning of 5-alpha-reductase medical term. What does 5-alpha-reductase mean?
Prospective studies suggest that prostate cancer risk may be increased in association with high serum concentrations of free testosterone and androstanediol glucuronide (A-diol-g). Polymorphisms have been identified in the 17-hydroxylase cytochrome P450 gene (CYP17) and the steroid 5alpha-reductase type II gene (SRD5A2), two genes that are involved in the biosynthesis and metabolism of androgens in men. The CYP17 MspA1 I polymorphism has been associated with increased prostate cancer risk, and the SRD5A2 V89L polymorphism has been associated with low A-diol-g in Asian men, a serum marker of 5alpha-reductase activity. The purpose of this study was to investigate the association between these two polymorphisms and serum sex hormone concentrations in 621 British men. In particular, we wanted to test the hypotheses that the A2 allele in the CYP17 gene is associated with increased serum testosterone concentrations, and the L allele in the SRD5A2 gene is associated with reduced A-diol-g concentrations. Mean
Invented are 17alpha and 17beta-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-alpha-reductase. Also invented are intermediates and processes used in preparing these compounds.
Complete information for SRD5A2 gene (Protein Coding), Steroid 5 Alpha-Reductase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for SRD5A1 gene (Protein Coding), Steroid 5 Alpha-Reductase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Treating symptoms of benign prostatic hyperplasia (BPH) in men who have an enlarged prostate gland. Dutasteride/tamsulosin is a 5 alpha-reductase inhibitor and alpha-blocker combination. The 5 alpha-reductase inhibitor (dutasteride) works by lowering levels of a hormone called dihydrotestosterone (DHT), which is a major cause of prostate growth. The alpha-blocker (tamsulosin) works by relaxing muscles in the prostate and bladder. Dutasteride/tamsulosin helps to decrease the size of the prostate and reduce symptoms of BPH.. Genérico Jalyn (Dutasteride + Tamsulosin 0.5mg + 0.4mg) € 3.03 comprimido -Salud Masculina @ Mydiscountpills.com: Fildena|Cenforce|Vidalista|Tadalista-UPD:2020. Cheap price on popular Indian brand names such as: Fildena, Cenforce, Vidalista, Tadalista and more! Full satisfaction of all Your desires :)
or those troubled vertebrae. * 29% increase in cardiovascular disease. primarily due to the higher levels of estrogen and HDL ( when can i buy dutasteride Wales UK, cheapest way get dutasteride, buy dutasteride generics online Longton, how can i buy dutasteride online no prescription, what is cheaper dutasteride or dutasteride Biddenden, canadian cheap dutasteride, dutasteride complete buy online United Kingdom, generic dutasteride soft buy, buy dutasteride online how to GB, how can you buy dutasteride legally, buy dutasteride online real Northern Ireland ...
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. [Wikipedia]
Where can i dutasteride in the uk, Buy dutasteride uk forum, Online dutasteride singapore, Dutasteride generic thailand, Brand name dutasteride online, Dutasteride purchase now store canada, Average dutasteride dosepak, Generic dutasteride hong kong
5-Alpha-reductase deficiency is an autosomal recessive intersex condition affecting XY individuals who are born with male gonads, including testicles and Wolffian structures, sometimes with obvious undervirilisation, but usually appear to have female primary sex characteristics.
This page displays a blog entry. Best Price for Dutasteride available online! Mexico Dutasteride Buy Online, How To Buy Dutasteride Denmark BUY Dutasteride ONLINE! - CLICK HERE! buy dutasteride medication onlinebuy dutasteride professional 0.5 mgbuy dutasteride nz onlineis buying dut...
Generic dutasteride news, Shoppers drug mart dutasteride price, Purchase dutasteride payment australia, Discount dutasteride wiki, Buy generic dutasteride online pharmacy
Connect and share your social channels in one place This page displays a blog entry. Cheapest Dutasteride Melbourne, Cheap Dutasteride Canada, Cheap Priced Dutasteride Canadian Pharmacy Order Dutasteride Online. Best Deal for Avodart on the net! BUY Dutasteride (Avodart) ONLINE! - CLICK HERE! dutasteride There are certain other prosta...
Dutasteride before and after, dutasteride avodart online, jalyn dutasteride-tamsulosin hydrochlorid, buy avodart dutasteride, avodart dutasteride price, dutasteride tablet, order dutasteride online
Dutasteride, along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT). This is the same chemical found in Proscar...
No prescription needed, approved pharmacy. Best Quality and EXTRA LOW PRICES! buy dutasteride dutasteride generic. Free pills for every order.
Buy finasteride online from canada Where to buy finasteride (proscar finasteride) Buy generic finasteride online uk Buy finasteride new zealand How to get finasteride cheap Buy finasteride Buy finasteride in singapore Cheap finasteride online australia Cheap finasteride canada Finasteride finasteride cheap
Best site to buy finasteride Buy generic finasteride online uk Finasteride cheap with prescription Cheap finasteride nz Best website to buy finasteride Where to buy finasteride (proscar finasteride) Is it illegal to order finasteride online Best place to order finasteride online Purchase finasteride canada Order finasteride online
Finasteride 5mg tab not. Camber Pharmaceuticals manufactures Finasteride, 5 mg - Propecia, Proscar Generic - with quality and integrity. A 5-alpha-reductase inhibitor for the treatment of.
Buy Duodart Online! Duodart belongs to a class of drugs called 5 alpha-reductase inhibitors. A class of drugs is a group of medications that work in a similar way.
Is it safe to order finasteride online Buy finasteride online from canada Finasteride mail order canada Buy finasteride thailand Where can i buy finasteride in the us Where can i buy cheap finasteride Best place to buy finasteride uk Buy cheap finasteride in uk Can i buy finasteride over the counter in canada Buy finasteride cvs
Brand finasteride fass, Generic finasteride target, Finasteride in nz, Order generic finasteride, Finasteride price, Finasteride price generic, Buy finasteride uk boots, Finasteride cream online uk
How does Proscar work? What will it do for me? Finasteride belongs to a group of medications known as 5-alpha-reductase inhibitors. Finasteride is used to ...
Finasteride tablets, finasteride impotence reversible, acheter finasteride propecia, finasterid 5mg rezeptfrei, dutasteride vs finasteride, finasteride results, finasteride cheaper than propecia
Investigators say they have found no association between the use of 5-alpha-reductase inhibitors (5ARIs) and the risk of developing high-grade or lethal prostate cancer.
Reaktivität: Rind (Kuh), Hund, Pferd and more. 71 verschiedene SRD5A2 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
Finasteride is an FDA-approved hair loss drug that works by blocking an enzyme that would otherwise change testosterone to DHT. It has to be taken every day and may take at least three months to take effect. It can have some side effects, including sexual problems, and its worth noting that if a man stops taking finasteride, the hair he grew back will probably be lost.. Finasteride comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take finasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take finasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.. If you are taking finasteride to treat BPH, you should know that finasteride may control your condition, but will not cure it. It may take at least 6 months before your symptoms improve. Continue to take finasteride even ...
(Video in English) 臨床診斷和研究報告顯示,無論醫生觀察到的頭髮數量,以致患者的主觀感受,服用 Dutasteride 比 Finasteride 效果更好。
Dutasteride - Partly from want of information, and partly to allay the anxiety of the mother, it was my misfortune to make light of the trouble, and even to hold out hopes for a cure.
Ordering finasteride online / finasteride 1mg cost / finasteride 5 mg per day / finasteride canada pharmacy : Today, that your picture of the oil and Swiss scientists who do not to normal.
Sprawdź ile zapłacisz za lek dutasteride/tamsulosin w aptece, znajdź tańsze zamienniki leku. Określ swoje uprawnienia i sprawdź jakie zniżki Ci przysługują.
Learn more about hair growth with Dutasteride, or Avodart, in Dallas with Dr. Samuel Lam of the Lam Institute of Hair Restoration
Find patient medical information for Dutasteride Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Folcres finasteride 1 mg, finasterid preis, propecia finasteride1mg, quanto costa finasteride propecia, buy finasteride uk, propecia finasteride cost, 59 propecia finasteride 1mg
Site Fiable Pour Achat Finasteride 5 Mg - Finasteride Acheter Pharmacie Finasteride 5 Ou Acheter Forum, Meilleur Site Achat Finasteride Achat De Finasteride…
Best prices for Dutas. Great price, EXPRESS shipping. Best Quality without a prescription. Safe and securely. Buy Cheap Dutas no prescription
Post finasteride syndrome - Diskuze V ce vlas .cz Chcel by som len kazdeho kto uva uje o uzivani finasteridu alebo dutasteridu poprosit aby si do googla zadal post finasteride syndrom , precital si o tom a az potom sa rozhodol ci mu vlasy stoja za to riziko. Bohuzial pred viac ako 15 rokmi kedy som bral finasteride tieto info neboli este zn me a finasterid posobil vtedy ako velmi bezpecna latka, bohuzial prax ukazala ze nie je a pravdepodobne or
Dutas no prescription. Express Delivery! Free Pills With Every Order! Best prices for excellent quality! Best offers for Dutas Online
Cheap Dutas from trusted pharmacy! Ed Tabs boosts your sexual energy. Different dosage avaible! Generic Tabs Online No Prescription. Purchase Dutas no prescription
Generic Dutas no prescription. ONLY HERE The Best QUALITY and LOW PRICES. Cheap Pills Online Store. Cheap Prices and No prescription required. Cheap generic Dutas
Dutas without prescription Online. Big Discounts. Save Time and Money. Ed Tabs boosts your sexual energy. Quality Generic Dutas No RX
3-oxo-5 beta-steroid delta 4-dehydrogenase: do not confuse with EC 1.3.1.23 (cholestenone 5 beta-reductase) which is also steroid 5 beta-reductase in Chemline; do not use for enzyme using NAD(P)-see EC 1.3.1.23 & EC 1.3.1.3
They say a picture is worth 1000 words. Clearly finasteride has had a remarkable impact on this young man. The dose of topical finasteride was subsidized with…
Find quality suppliers and manufacturers of Finasteridefor price inquiry.where to buy Finasteride.Also offer free database of Finasteride including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Finasteride Portfarma is a medicine available in a number of countries worldwide. A list of US medications equivalent to Finasteride Portfarma is available on the Drugs.com website.
I have SOS v998 and AE v74. I emailed him today after being reminded of it due to this thread. There is a new SOS due out soon, and there is a fair bit to be added to AE as well, but that one wont be for a while.. The DHT cycling for PE is a good theory, but we have lots of good theories that dont stand up when tested for one reason or another. I believe he got the effects he claimed, but I for one can say that not everyone reacts the same in this instance. I didnt add DHT at the time, because I was unaware of this protocol and was cycling off for other reasons (a rest from it).. I know of no link that shows normal or abnormal levels of DHT being the cause of hairloss. Imho (though plenty will disagree), linking hairloss to DHT is as tenuous a link as excess calories is to obesity; there is certainly a correlation, but it isnt absolutely true either. Hairloss is (as far as we know), an immune response in genetically susceptible follicles rather than a DHT level issue. Thats why Fin, Dut, ...
going to get on the shakes but really want to avoid anything with creatine as the stuff is reported to boost dht levels among other things. can someone recommend a shake thats not as artificial, one that youve found does not mess with you mpb?
Generico Proscar Dove posso acquistare generico Finasteride senza prescrizione. Proscar Generico è usato nel trattamento dei disturbi causati dall
Hi, ive been for 2,5 months on finasteride now, and for the first time yesterday i experienced ball ache on my left testicle, the think is that i...
Listados de especialidades Esta página contiene listados de especialidades farmacéuticas autorizadas del principio activo finasterida en los países
In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction 5alpha-cholestan ... Other names in common use include testosterone Delta4-5alpha-reductase, steroid 5alpha-reductase, 3-oxosteroid Delta4- ... 4-ene-5alpha-reductase, Delta4-3-ketosteroid 5alpha-oxidoreductase, cholest-4-en-3-one 5alpha-reductase, and testosterone ... 3-oxosteroid 5alpha-reductase, testosterone Delta4-hydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, reduced nicotinamide ...
... alpha -substrate}+NADP+}}} 5α-DHP is a major hormone in circulation of normal cycling and pregnant women. 5α-Reductase is most ... Cholestenone5α-Cholestanone Progesterone → 5α-Dihydroprogesterone 3α-Dihydroprogesterone → Allopregnanolone 3β- ... Killian J, Pratis K, Clifton RJ, Stanton PG, Robertson DM, O'Donnell L (May 2003). "5alpha-reductase isoenzymes 1 and 2 in the ... Thiele S, Hoppe U, Holterhus PM, Hiort O (June 2005). "Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal ...
... cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, ... Delta4-3-oxosteroid+5beta-reductase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... Charbonneau A, The VL (January 2001). "Genomic organization of a human 5beta-reductase and its pseudogene and substrate ... 5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, ...
... cholestenone 5alpha-reductase MeSH D08.811.682.660.250 - coproporphyrinogen oxidase MeSH D08.811.682.660.275 - ... gtp-binding protein alpha subunits MeSH D08.811.277.040.330.300.200.100.100 - gtp-binding protein alpha subunits, g12-g13 MeSH ... gmp reductase MeSH D08.811.682.655.500 - nitrate reductases MeSH D08.811.682.655.500.124 - nitrate reductase MeSH D08.811. ... nitrite reductases MeSH D08.811.682.655.750.249 - ferredoxin-nitrite reductase MeSH D08.811.682.655.750.500 - nitrite reductase ...
7-dehydrocholesterol reductase EC 1.3.1.22: cholestenone 5a-reductase EC 1.3.1.23: cholestenone 5b-reductase is identical to EC ... alpha-pinene monooxygenase EC 1.14.13.156: 1,8-cineole 2-endo-monooxygenase EC 1.14.13.157: 1,8-cineole 2-exo-monooxygenase EC ... flavin reductase (NADH) EC 1.5.1.37: FAD reductase (NADH) EC 1.5.1.38: FMN reductase (NADPH) EC 1.5.1.39: FMN reductase (NAD(P) ... zeatin reductase EC 1.3.1.70: D14-sterol reductase EC 1.3.1.71: D24(241)-sterol reductase EC 1.3.1.72: D24-sterol reductase EC ...
In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction 5alpha-cholestan ... Other names in common use include testosterone Delta4-5alpha-reductase, steroid 5alpha-reductase, 3-oxosteroid Delta4- ... 4-ene-5alpha-reductase, Delta4-3-ketosteroid 5alpha-oxidoreductase, cholest-4-en-3-one 5alpha-reductase, and testosterone ... 3-oxosteroid 5alpha-reductase, testosterone Delta4-hydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, reduced nicotinamide ...
Cholestenone 5 alpha-Reductase * Double-Blind Method * Enzyme Inhibitors / administration & dosage * Enzyme Inhibitors / ... A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5- ... alpha-reductase in the treatment of androgenetic alopecia J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm. ... via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic ...
... work is to synthesize a pregnane derivative with a high antiandrogenic effect or a high inhibitory activity for the enzyme 5 ... alpha-reductase type 2. Benign prostatic hyperplasia and prostate cancer are androgen dependent diseases which afflict a large ... Cholestenone 5 alpha-Reductase * Gonadotropin-Releasing Hormone / agonists * Humans * Male * Oxidoreductases / antagonists & ... On the other hand, the 4-halo (bromo and chloro) 17 alpha-acetoxy (58, 59) and the 17 alpha-benzoyloxy-4-chloro analog 63 ...
... into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It ... cholestenone 5-alpha-reductase activity Source: UniProtKB-EC. *oxidoreductase activity Source: GO_Central ,p>Inferred from ... "Identification of missense mutations in the SRD5A2 gene from patients with steroid 5alpha-reductase 2 deficiency.". Vilchis F. ... "New mutations, hotspots, and founder effects in Brazilian patients with steroid 5alpha-reductase deficiency type 2.". Hackel C. ...
cholestenone 5alpha-reductase;. testosterone Delta4-5alpha-reductase;. steroid 5alpha-reductase;. 3-oxosteroid Delta4- ... 4-ene-5alpha-reductase;. Delta4-3-ketosteroid 5alpha-oxidoreductase;. cholest-4-en-3-one 5alpha-reductase;. testosterone 5alpha ... 5alpha-reductase;. steroid 5alpha-hydrogenase;. 3-oxosteroid 5alpha-reductase;. testosterone Delta4-hydrogenase;. 4-ene-3- ... 5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the ...
... on phospholipase and on aldose reductase and being useful for the prevention and/or treatment of diseases induced by ... phospholipase and aldose reductase in mammals, especially in human beings. ... R 5 , R 6 , R 7 , R 8 , U, n, m, p, q, R 5 , and R 6 are defined as in the above specification, possessing antagonistic ... activity on leukotrienes (SRS), inhibitory activity on 5α-reductase, ...
Such compounds are useful as selective antagonists of testosterone 5α-reductase 1. ... NHR 5 , and R 5 is selected from the group consisting of hydrogen and C 1-10 alkylcarbonyl. ... 108010066551 Cholestenone 5 alpha-Reductase Proteins 0 description 10 * 229910017917 NH4 Cl Inorganic materials 0 description ... 238000003818 flash chromatography Methods 0 description 5 * 238000004128 high performance liquid chromatography Methods 0 ...
Steroid 5 Alpha-Reductase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... Micropenis and the 5alpha-reductase-2 (SRD5A2) gene: mutation and V89L polymorphism analysis in 81 Japanese patients. (PMID: ... acting on the CH-CH group of donors and cholestenone 5-alpha-reductase activity. An important paralog of this gene is SRD5A1. ... Alpha Polypeptide 2 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) 2 3 ...
Steroid 5 Alpha-Reductase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review. (PMID: 19914946) Li J … Khoury ... GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and cholestenone 5- ... The GeneCards human gene database index: 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
The 5alpha-reductase type II variants studied did not show links with prostate hyperplasia. The androgen receptor gene CAG ... Steroid 17-alpha-Hydroxylase / genetics* Actions. * Search in PubMed * Search in MeSH ... Cholestenone 5 alpha-Reductase Actions. * Search in PubMed * Search in MeSH * Add to Search ... 5alpha-reductase type 2 (TA repeats, V89L and A49T mutations), A2 variant of the 17alpha-hydroxylase (CYP17) and the simple ...
Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2). Lunn RM, Bell DA, Mohler JL, ... Steroid 17-alpha-Hydroxylase / genetics Actions. * Search in PubMed * Search in MeSH ... Cholestenone 5 alpha-Reductase Actions. * Search in PubMed * Search in MeSH * Add to Search ... 5alpha-reductase type II (SRD5A2), p450c17 (CYP17), and aromatase (CYP19) genes. The different polymorphisms in prostate ...
... alpha -substrate}+NADP+}}} 5α-DHP is a major hormone in circulation of normal cycling and pregnant women. 5α-Reductase is most ... Cholestenone5α-Cholestanone Progesterone → 5α-Dihydroprogesterone 3α-Dihydroprogesterone → Allopregnanolone 3β- ... Killian J, Pratis K, Clifton RJ, Stanton PG, Robertson DM, ODonnell L (May 2003). "5alpha-reductase isoenzymes 1 and 2 in the ... Thiele S, Hoppe U, Holterhus PM, Hiort O (June 2005). "Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal ...
Mechanism of Action Alpha 1 adrenergic receptor antagonists; Cholestenone 5-alpha reductase inhibitors ...
Cholestenone 5 alpha-Reductase Medicine & Life Sciences * Genitalia Medicine & Life Sciences * Testosterone Medicine & Life ... BERKOVITZ, GARY D. ; BROWN, TERRY R. ; MIGEON, AND CLAUDE J. / Inhibition of 5a‐Reductase Activity and Alteration of Nuclear ... Inhibition of 5a‐Reductase Activity and Alteration of Nuclear Testosterone: Dihydrotestosterone Ratio in Human Genital Skin ... Inhibition of 5a‐Reductase Activity and Alteration of Nuclear Testosterone: Dihydrotestosterone Ratio in Human Genital Skin ...
Tumor Necrosis Factor-alpha 腫瘍壊死因子アルファ Fluorenes フルオレン ... Cholestenone 5 alpha-Reductase コレステノン5アルファ-レダクターゼ Sucrase スクラーゼ ... Cortisone Reductase コルチゾンレダクターゼ Enzyme Inhibitors 酵素阻害剤 ... 3-Oxo-5-alpha-Steroid 4-Dehydrogenase 3-ケト-5-アルファ-ステロイドデルタ-
Kalin, R., McCormac, F. G., Damon, P. E., Eastoe, C. J. & Long, A., 1995, In: Radiocarbon. 37, 1, p. 33-38 5 p.. Research ... MacQuarrie, A., 1995, In: Annual Report of the Society of Friends of Govan Old. 5, p. 25-32 7 p.. Research output: Contribution ... Vatanpour, H. & Harvey, A. L., Apr 1995, In: British Journal of Pharmacology. 114, 7, p. 1502-1506 5 p.. Research output: ... Hill, D. & Infield, D. G., Nov 1995, In: IEE Proceedings Generation Transmission and Distribution. 142, 6, p. 555-559 5 p.. ...
Pyne, N. J. & Pyne, S., 1993, In : Cellular Signalling. 5, 4, p. 401-409 9 p.. Research output: Contribution to journal › ... Inglis, W. L., Dunbar, J. S. & Winn, P., 25 Jun 1993, In : Neuroscience Letters. 156, 1-2, p. 78-82 5 p.. Research output: ... Stack, M. & Stott, F. H., 1993, In : Corrosion Science. 35, 5-8, p. 1027-1034 8 p.. Research output: Contribution to journal › ... Price, C. J., 1 Mar 1993, In : Journal of Crystal Growth. 128, 1-4, p. 1277-1281 5 p.. Research output: Contribution to journal ...
Cholestenone 5 alpha-Reductase Contraceptive Agents, Male Dihydrotestosterone Enzyme Inhibitors Epididymis Female Fertilization ... alpha- steroid 4- dehydrogenase (2). *5 alpha reductase inhibitors (2) ... Actions of 5alpha-reductase inhibitors on the epididymis. Molecular and cellular endocrinology. 2006 May 16;250(1-2):190-5 ... Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the ...
Simmons, J. D., Dearmond, D. T. & Calhoon, J. H., Jan 5 2012, Cardiothoracic Surgery Review. Wolters Kluwer Health Adis (ESP), ... 5. p. 291-327 37 p.. Research output: Chapter in Book/Report/Conference proceeding › Chapter ... Conway, D. L., May 5 2011, Stillbirth: Prediction, Prevention and Management. Wiley-Blackwell, p. 117-131 15 p.. Research ... Saltzman, W., Tardif, S. D. & Rutherford, J. N., Dec 1 2011, Hormones and Reproduction of Vertebrates - Volume 5. Elsevier Inc. ...
The type 1 5alpha-reductase selective inhibitor 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one, but not the type 2 selective ... Cholestenone 5 alpha-Reductase. *Cyproterone Acetate/pharmacology. *Dehydroepiandrosterone/metabolism. *Enzyme Inhibitors/ ... Furthermore, the effects of the selective 5alpha-reductase type 1 and 2 inhibitors, 4,7beta-dimethyl-4-aza-5alpha-cholestan-3- ... Type 2 17beta-hydroxysteroid dehydrogenase, type 1 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase mRNA were ...
... cholestenone 5-alpha-reductase activity • amide binding • NADPH binding... ... cholestenone 5-alpha-reductase activity. • amide binding. • NADPH binding. • electron carrier activity. • oxidoreductase ... 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Cellular component. • cytoplasm. • integral component of membrane. • organelle ...
Adrenergic alpha-Antagonists/therapeutic use , Cholestenone 5 alpha-Reductase/antagonists & inhibitors , Data Collection , ... Effect of selective 5alpha-reductase inhibitor or/and testosterone undecanoate on the reproductive function of male rats / 中华男科 ... Humans , Male , Adrenergic alpha-Antagonists , Cholestenone 5 alpha-Reductase/antagonists & inhibitors , Phytotherapy , ... Of the respondents, 57.2% had prescribed alpha blocker and 41.6% alpha blocker plus 5-alpha reductase inhibitors as the medical ...
Adrenergic alpha-Antagonists/therapeutic use , Cholestenone 5 alpha-Reductase/antagonists & inhibitors , Data Collection , ... Humans , Male , Adrenergic alpha-Antagonists , Cholestenone 5 alpha-Reductase/antagonists & inhibitors , Phytotherapy , ... Of the respondents, 57.2% had prescribed alpha blocker and 41.6% alpha blocker plus 5-alpha reductase inhibitors as the medical ... The prescription of 5-ARIs was dependent on the size of the prostate and the severity of symptoms. CONCLUSION: The results of ...
... is an orally-active 5α-reductase inhibitor developed by Ono (Japan) for the treatment of benign prostatic hyperplasia. It ... Mechanism of Action Cholestenone 5-alpha reductase inhibitors * Orphan Drug Status Orphan designation is assigned by a ...
PubMed journal article Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian- ... 17-diolAndrosteroneAsian Continental Ancestry GroupBiomarkersBritish ColumbiaCaliforniaCase-Control StudiesCholestenone 5 alpha ... Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men.. Cancer ... "Lifestyle Determinants of 5alpha-reductase Metabolites in Older African-American, White, and Asian-American Men." Cancer ...
25-Hydroxyvitamin D3 1-alpha-Hydroxylase. *3 Untranslated Regions. *Ablation Techniques. *Academic Medical Centers ... Cholestenone 5 alpha-Reductase. *Cholesterol. *Chromosome Deletion. *Chromosome Mapping. *Chromosomes, Human, Pair 12 ...
... est le premier et le.Cholestenone 5 alpha-Reductase. as well as 5 alpha-reductase inhibitors N,N-diethyl-4-methyl-3-oxo-4-aza-5 ... My online accutane order behinds whenever im decreasing low,. In addition, alpha-methyl-p-tyrosine,. Hmg coa-reductase ... Crestor is a HMG CoA reductase {inhibitor,prevention} {used.. Defect in dihydropteridine reductase - Orphanet. Free online ... Ribonucleotide reductase inhibitor : définition de. Generic Avodart (Dutas) is a. dutasteride belongs to a group of 5-alpha- ...
The effects of synthetic alpha-subunit peptides on thyroid-stimulating immunoglobulin activity.. 1988 J C 3rd Morris et al. ... Aged, Aged, 80 and over, Cholestenone 5 alpha-Reductase, Dihydrotestosterone, metabolism, Epithelium, enzymology, Humans, ... Cyclic AMP, biosynthesis, Female, Glycoprotein Hormones, alpha Subunit, Graves Disease, immunology, Humans, Immunoglobulin G, ... Kinetic parameters of 5 alpha-reductase activity in stroma and epithelium of normal, hyperplastic, and carcinomatous human ...
8,834 +/- 4,487 microg/24 h; P = 0.001). 5 alpha-Reductase activity correlated with BMI, insulin levels, and homeostasis model ... Both obese and nonobese PCOS patients had higher 5 alpha-reductase activity than controls (all P , 0.05). 11 beta- ... CONCLUSIONS: PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5 alpha-reductase ... 5 alpha-reductase, and 11 beta-hydroxysteroid dehydrogenase types 1 and 2. We also measured circulating levels of glucose, ...
Cholestenone 5alpha-reductase Current Synonym true false 2647400010 3-Oxo-5alpha-steroid delta^4^-dehydrogenase Current Synonym ... Testosterone 5-alpha-reductase Current Synonym true false 144134010 ... Cholestenone 5alpha-reductase (substance). Code System Preferred Concept Name. Cholestenone 5alpha-reductase (substance). ...
  • Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). (nih.gov)
  • Dihydrotestosterone 3, a 5 alpha-reductase metabolite of testosterone 2 has been implicated as a causative factor in the progression of these diseases, largely through the clinical evaluation of males who are genetically deficient of steroid 5 alpha-reductase enzyme. (nih.gov)
  • Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. (uniprot.org)
  • Outside of dihydrotestosterone, much of the physiological role of 5α-reduced steroids is unknown. (wikipedia.org)
  • Beyond reducing testosterone to dihydrotestosterone, 5alpha-reductase enzyme isoforms I and II reduce progesterone to dihydroprogesterone (DHP) and deoxycorticosterone to dihydrodeoxycorticosterone (DHDOC). (wikipedia.org)
  • 5α-Reductase is most known for converting testosterone, the male sex hormone, into the more potent dihydrotestosterone: Testosterone. (wikipedia.org)
  • Dihydrotestosterone The major difference is the Δ4,5 double-bond on the A (leftmost) ring. (wikipedia.org)
  • When fibroblasts were incubated in the presence of testosterone (T) and 4-MA, nuclear uptake of 5 alpha-dihydrotestosterone (DHT) decreased in parallel with the inhibition of 5 alpha-reductase activity. (elsevier.com)
  • BERKOVITZ, GARYD , BROWN, TERRYR & MIGEON, ANDCLAUDEJ 1984, ' Inhibition of 5a‐Reductase Activity and Alteration of Nuclear Testosterone: Dihydrotestosterone Ratio in Human Genital Skin Fibroblasts ', Journal of Andrology , vol. 5, no. 3, pp. 171-175. (elsevier.com)
  • Propecia inhibits expression of the enzyme, 5-alpha reductase, which regulates the production of dihydrotestosterone (DHT). (statescale.tk)
  • Actions of 5alpha-reductase inhibitors on the epididymis. (nextbio.com)
  • Furthermore, the effects of the selective 5alpha-reductase type 1 and 2 inhibitors, 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one and dihydrofinasteride, respectively, and of the 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase inhibitor cyproterone acetate on androgen metabolism were investigated. (nih.gov)
  • Of the respondents, 57.2% had prescribed alpha blocker and 41.6% alpha blocker plus 5-alpha reductase inhibitors as the medical treatment option for BPH. (bvsalud.org)
  • as well as 5 alpha-reductase inhibitors N,N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carboxyamide and 4. (catalogtovarov.gq)
  • but no guarantee is made to the drug class 5-alpha-reductase inhibitors. (catalogtovarov.gq)
  • inhibitors of 5-alpha-reductase.Frontal fibrosing alopecia (FFA). (catalogtovarov.gq)
  • tetracycline antibiotics and oral 5-alpha-reductase inhibitors seem to slow the process down.5. (catalogtovarov.gq)
  • called 5 alpha reductase inhibitors. (catalogtovarov.gq)
  • Before It's News) Publisher's, "5-Alpha Reductase Inhibitors-Pipeline Insights, 2016″, report provides in depth insights on the pipeline drugs and. (catalogtovarov.gq)
  • Generic Avodart (Dutas) is a. dutasteride belongs to a group of 5-alpha-reductase inhibitors. (catalogtovarov.gq)
  • SRD5A2 (Steroid 5 Alpha-Reductase 2) is a Protein Coding gene. (genecards.org)
  • Two hundred twenty-six patients with the pathologic diagnosis of sporadic prostate tumor and 156 healthy matched (age, ethnic group) male controls from a large epidemiologic cohort were genotyped for previously described polymorphisms in the androgen receptor (AR), 5alpha-reductase type II (SRD5A2), p450c17 (CYP17), and aromatase (CYP19) genes. (cdc.gov)
  • There are three isozymes of 5α-reductase, SRD5A1, SRD5A2, and SRD5A3, which vary in different tissues with age. (wikipedia.org)
  • There are three isoenzymes of 5α-reductase: steroid 5α-reductase 1, 2, and 3 (SRD5A1, SRD5A2 and SRD5A3). (wikipedia.org)
  • The advent of finasteride 22 "figure 5" a 5 alpha-reductase inhibitor, has greatly alleviated the symptoms associated with benign prostatic hyperplasia. (nih.gov)
  • The type 1 5alpha-reductase selective inhibitor 4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one, but not the type 2 selective inhibitor dihydrofinasteride, inhibited 5alpha-reductase at low concentrations in SZ95 sebocytes and HaCaT keratinocytes. (nih.gov)
  • BACKGROUND: Dutasteride is an inhibitor of both types I and II 5 alpha-reductase and was approved in Korea in April 2004. (bvsalud.org)
  • Avodart 5 Alpha Reductase Inhibitor DUTASTERIDE(MANS HEALTH) 0.5MG simcoeopen.com » avodart 5 alpha reductase inhibitor avodart 5 alpha reductase inhibitor.Hidradenitis Suppurativa. (catalogtovarov.gq)
  • Finasteride is a competitive inhibitor of the 5-alpha reductase type II isoenzyme. (catalogtovarov.gq)
  • but krill oil is also pretty sturdy 5 alpha-reductase inhibitor. (catalogtovarov.gq)
  • 5 lasix purchase (base) a. a countermeasure angiotensin-converting hipopotasemia inhibitor. (catalogtovarov.gq)
  • 17 DDT), a potent 5 alpha reductase inhibitor (finasteride) and two known negative chemicals. (catalogtovarov.gq)
  • Avodart is categorized as a 5-alpha-reductase inhibitor and. (catalogtovarov.gq)
  • The Accutane is an inhibitor of 5 alpha reductase and. (catalogtovarov.gq)
  • Definitions of 5-alpha reductase inhibitor, synonyms, antonyms, derivatives of 5-alpha reductase inhibitor, analogical dictionary of 5-alpha reductase inhibitor (English). (catalogtovarov.gq)
  • Hmg coa-reductase neurologists gonadectomized by cyp3a4,.Dutasteride is a 5 alpha-reductase enzyme inhibitor and works by lowering production of a hormone called. (catalogtovarov.gq)
  • These compounds were prepared from the commercially available 17 alpha-acetoxy progesterone 56. (nih.gov)
  • Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. (hmdb.ca)
  • 5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. (wikipedia.org)
  • MAIN OUTCOME MEASURES: We measured urinary steroid metabolites including glucocorticoids and androgens and the ratios reflecting enzymatic activities involved in peripheral cortisol and androgen metabolism, 5 alpha-reductase, and 11 beta-hydroxysteroid dehydrogenase types 1 and 2. (ox.ac.uk)
  • Altered endogenous glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which generates active cortisol from cortisone, and 5alpha-reductase (5alphaR), which inactivates cortisol, has been implicated. (ox.ac.uk)
  • 5α-reductase has been proven a good target through finasteride use. (bvsalud.org)
  • In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction 5alpha-cholestan-3-one + NADP+ ⇌ {\displaystyle \rightleftharpoons } cholest-4-en-3-one + NADPH + H+ Thus, the two substrates of this enzyme are 5alpha-cholestan-3-one and NADP+, whereas its 3 products are cholest-4-en-3-one, NADPH, and H+. (wikipedia.org)
  • CONCLUSIONS: PCOS is associated with enhanced androgen and cortisol metabolite excretion and increased 5 alpha-reductase activity that cannot be explained by obesity alone. (ox.ac.uk)
  • The reaction involves a stereospecific and permanent break of the Δ4,5 with the help of NADPH as a cofactor. (wikipedia.org)
  • Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. (wikipedia.org)
  • 2001 Sep 1;92(5):1130-7. (cdc.gov)
  • 2001 May;116(5):793-800. (nih.gov)
  • Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 5, 2001, pp. 533-8. (unboundmedicine.com)
  • 2001;10(5):533-8. (unboundmedicine.com)
  • Restriction analysis of cDNA fragments was performed to identify isozymes of 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase and 3alpha-hydroxysteroid dehydrogenase. (nih.gov)
  • 5α-R1 is expressed in fetal scalp and nongenital skin of the back, anywhere from 5 to 50 times less than in the adult. (wikipedia.org)
  • 5α-R2 is expressed in prostate, seminal vesicles, epididymis, liver, and to a lesser extent the scalp and skin. (wikipedia.org)
  • 5α-R1 is expressed mainly in the epithelium and 5α-R2 the stroma of the fetal prostate. (wikipedia.org)
  • Kinetic parameters of 5 alpha-reductase activity in stroma and epithelium of normal, hyperplastic, and carcinomatous human prostates. (naver.com)
  • The purpose of this work is to synthesize a pregnane derivative with a high antiandrogenic effect or a high inhibitory activity for the enzyme 5 alpha-reductase type 2. (nih.gov)
  • Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors and cholestenone 5-alpha-reductase activity . (genecards.org)
  • We have tested genetic susceptibility to morphological and pathological criteria in 195 French Caucasians, using allelic variants for candidate genes involved in androgen/oestrogen prostatic activity: androgen receptor (CAG repeats), 5alpha-reductase type 2 (TA repeats, V89L and A49T mutations), A2 variant of the 17alpha-hydroxylase (CYP17) and the simple tandem repeat polymorphism (STRP) aromatase (CYP19) polymorphisms. (cdc.gov)
  • 17 beta-N, N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one (4-MA) inhibits 5 alpha-reductase activity in cultured human genital skin fibroblasts. (elsevier.com)
  • Androgen receptor mRNA was detected in SZ95 sebocytes and HaCaT keratinocytes but not in MeWo melanoma cells, whereas 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase isotype 1 mRNA and metabolic activity were only found in SZ95 sebocytes. (nih.gov)
  • Anti-inflammatory activity was also assessed by the expression levels of tumor necrosis factor-alpha (TNF-α) and interleukin 6. (bvsalud.org)
  • Overall, RE-ORGA is expected to alleviate hair loss by regulating 5α-reductase activity and the receptor's androgen sensitivity. (bvsalud.org)
  • [email protected]#KR+C can reduce the prostatic volume of PH mice by decreasing the activity of 5α- reductase, inhibiting the expressions of FGF2, Ki67 and TGF-β1, and promoting the apoptosis of prostatic cells. (bvsalud.org)
  • Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. (unboundmedicine.com)
  • This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? (unboundmedicine.com)
  • To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. (unboundmedicine.com)
  • In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. (unboundmedicine.com)
  • The effects of synthetic alpha-subunit peptides on thyroid-stimulating immunoglobulin activity. (naver.com)
  • Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome. (ox.ac.uk)
  • 5 alpha-Reductase activity correlated with BMI, insulin levels, and homeostasis model assessment. (ox.ac.uk)
  • Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. (ox.ac.uk)
  • Propecia works by inhibiting 5 alpha-reductase activity. (tophairlosstreatments.com)
  • The mRNA expression patterns of the androgen receptor and the androgen metabolizing enzymes 3beta-hydroxysteroid dehydrogenase/Delta(5-4)-isomerase, 17beta-hydroxysteroid dehydrogenase, 5alpha-reductase, and 3alpha-hydroxysteroid dehydrogenase were investigated in three different cell populations originating from human skin, SZ95 sebocytes, HaCaT keratinocytes, and MeWo melanoma cells, by means of reverse transcription polymerase chain reaction. (nih.gov)
  • Hepatic expression of both 5α-R1 and 2 is immediate, but disappears in the skin and scalp at month 18. (wikipedia.org)
  • The major metabolic steps of testosterone in SZ95 sebocytes, primary sebocyte cultures, and HaCaT keratinocytes were its conversion to androstenedione by 17beta-hydroxysteroid dehydrogenase and further to 5alpha-androstanedione by 5alpha-reductase. (nih.gov)
  • The pharmacological evaluation of these steroids "figure 14" indicated that the 17 alpha-benzoyloxy derivatives (4-chloro and bromo) 62 and 63 were very potent antiandrogens. (nih.gov)
  • 5α-dihydroaldosterone is a potent antinatriuretic agent, although different from aldosterone. (wikipedia.org)
  • Several compounds have been reported to inhibit either one or both forms of 5alpha-reductase in many tissues. (nextbio.com)
  • The pseudohermaphrodites described in this 1974 study were born with a rare congenital 5 alpha-reductase deficiency . (tophairlosstreatments.com)
  • The 5alpha-reductase type II variants studied did not show links with prostate hyperplasia. (cdc.gov)
  • 5α-R2 is expressed in fetal prostates similar to adults. (wikipedia.org)
  • We performed MTT assays for cytotoxicity, Cell Counting Kit-8 assays for cell proliferation, and western blot to identify expression levels of 5α-reductase and Bax. (bvsalud.org)
  • It also inhibited the expression of 5α-reductases and Bax in the cells. (bvsalud.org)
  • 5α-Reductases act on 3-oxo (3-keto), Δ4,5 C19/C21 steroids as its substrates. (wikipedia.org)
  • 5α-Reductases catalyze the following chemical reaction: a 3-oxo-5α-steroid + acceptor ⇌ a 3-oxo-Δ4-steroid + reduced acceptor Thus, the two substrates of these enzymes are a 3-oxo-5α-steroid and acceptor, whereas its two products are 3-oxo-Δ4-steroid and a reduced acceptor. (wikipedia.org)
  • In socially isolated mice, 5α-R1 is specifically down-regulated in glutamatergic pyramidal neurons that converge on the amygdala from cortical and hippocampal regions. (wikipedia.org)
  • All the mice except those in the blank control group were subcutaneously injected with testosterone propionate (5 mg / [kg·d]) at 7 days after surgical castration. (bvsalud.org)