Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A class in the phylum CNIDARIA, comprised mostly of corals and anemones. All members occur only as polyps; the medusa stage is completely absent.
Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.
A plant genus in the CHENOPODIACEAE family.
A plant genus of the family POACEAE. The seed is one of the EDIBLE GRAINS used in millet cereals and in feed for birds and livestock (ANIMAL FEED). It contains diosgenin (SAPONINS).
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.
Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called "systemic" hemibody irradiation with reference to its use in widespread cancer or metastases. (P. Rubin et al. Cancer, Vol 55, p2210, 1985)
Cholestadiene derivatives containing a hydroxy group anywhere in the molecule.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Abnormally high level of calcium in the blood.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. (1/116)

Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is shown here that the human lung has a higher content of 27-hydroxycholesterol relative to cholesterol than any other organ. In order to evaluate the importance of the sterol 27-hydroxylase mechanism for cholesterol homeostasis in the lung, the production of cholestenoic acid by human lung was investigated. Removal of one lung reduced the level of cholestenoic acid in the circulation by 48 +/- 4% (P < 0.005). The levels of cholestenoic acid in the pulmonary artery and in the pulmonary vein showed significant differences (P < 0.002) with higher levels in the pulmonary vein (108 +/- 16 and 104 +/- 16 ng/mL, respectively). This corresponds to a net flux of cholestenoic acid from the lung of about 14 mg/day, which is more than 80% of the reported removal of this oxysterol and its metabolites from the circulation by the liver per day. Bypassing the lung for 60 min led to a reduction in circulating cholestenoic acid (30%) that fits with a pulmonary origin when taking into account the half-life of cholestenoic acid. The level of circulating cholestenoic acid was found to be less in patients with different lung diseases. It is evident that most of the cholestenoic acid in the circulation is of pulmonary origin. The present results suggest that the sterol 27-hydroxylase in the lung is responsible for at least half of the total flux of 27-oxygenated cholesterol metabolites to the liver and that this enzyme system may be of importance for cholesterol homeostasis in the lung.  (+info)

Meiosis-activating sterol-mediated resumption of meiosis in mouse oocytes in vitro is influenced by protein synthesis inhibition and cholera toxin. (2/116)

To explore the possible signaling pathways of meiosis-activating sterol (MAS)-induced oocyte maturation and to elucidate whether the MAS pathway involves transcription or translation, arrested immature mouse oocytes were cultured with either the protein synthesis inhibitor cycloheximide or the heteronuclear RNA inhibitors alpha-amanitin or actinomycin D, respectively. Moreover, the possible involvement of a G protein-coupled receptor mechanism in MAS-mediated oocyte maturation was explored by influencing oocyte maturation with cholera toxin (CT). MAS-induced oocyte maturation was completely blocked by the addition of 50 microg/ml cycloheximide 4 h before the addition of MAS. Simultaneous addition of MAS and the protein synthesis inhibitor also significantly reduced the meiotic resumption compared to that in MAS-treated controls. In contrast, neither of the treatment regimens to inhibit transcription of DNA to RNA was observed to have any effect on the MAS-induced resumption of meiosis. CT was observed to inhibit MAS-induced, but not spontaneous, oocyte maturation in vitro, suggesting a putative involvement of G protein-coupled receptor mechanism in the MAS mode of action. In conclusion, protein synthesis was found to be an essential requirement for maintaining the oocytes' responsiveness to MAS-induced resumption of meiosis, in contrast to transcription.  (+info)

Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. (3/116)

Two sterols of the cholesterol biosynthetic pathway induce resumption of meiosis in mouse oocytes in vitro. The sterols, termed meiosis-activating sterols (MAS), have been isolated from human follicular fluid (FF-MAS, 4,4-dimethyl-5 alpha-cholest-8,14,24-triene-3 beta-ol) and from bull testicular tissue (T-MAS, 4,4-dimethyl-5 alpha-cholest-8,24-diene-3 beta-ol). FF-MAS is the first intermediate in the cholesterol biosynthesis from lanosterol and is converted to T-MAS by sterol delta 14-reductase. An inhibitor of delta 7-reductase and delta 14 reductase, AY9944-A-7, causes cells with a constitutive cholesterol biosynthesis to accumulate FF-MAS and possibly other intermediates between lanosterol and cholesterol. The aim of the present study was to evaluate whether AY9944-A-7 added to cultures of cumulus-oocyte complexes (COC) from mice resulted in accumulation of MAS and meiotic maturation. AY9944-A-7 stimulated dose dependently (5-25 mumol l-1) COC to resume meiosis when cultured for 22 h in alpha minimal essential medium (alpha-MEM) containing 4 mmol hypoxanthine l-1, a natural inhibitor of meiotic maturation. In contrast, naked oocytes were not induced to resume meiosis by AY9944-A-7. When cumulus cells were separated from their oocytes and co-cultured, AY9944-A-7 did not affect resumption of meiosis, indicating that intact oocyte-cumulus cell connections are important for AY9944-A-7 to exert its effect on meiosis. Cultures of COC with 10 mumol AY9944-A-7 l-1 in the presence of [3H]mevalonic acid, a natural precursor for steroid synthesis, resulted in accumulation of labelled FF-MAS, which had an 11-fold greater amount of radioactivity incorporated per COC compared with the control culture without AY9944-A-7. In contrast, incorporation of radioactivity into the cholesterol fraction was reduced 30-fold in extracts from the same oocytes. The present findings demonstrate for the first time that COC can synthesize cholesterol from mevalonate and accumulate FF-MAS in the presence of AY9944-A-7. Furthermore, AY9944-A-7 stimulated meiotic maturation dose dependently, indicating that FF-MAS, and possibly other sterol intermediates of the cholesterol synthesis pathway, play a central role in stimulating mouse oocytes to resume meiosis. The results also indicate that oocytes may not synthesize steroids from mevalonate.  (+info)

Lanosterol 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol. (4/116)

Lanosterol 14alpha-demethylase (CYP51) is a cytochrome P450 enzyme involved primarily in cholesterol biosynthesis. CYP51 in the presence of NADPH-cytochrome P450 reductase converts lanosterol to follicular fluid meiosis activating sterol (FF-MAS), an intermediate of cholesterol biosynthesis which accumulates in gonads and has an additional function as oocyte meiosis-activating substance. This work shows for the first time that cholesterogenic enzymes are highly expressed only in distinct stages of spermatogenesis. CYP51, NADPH-P450 reductase (the electron transferring enzyme needed for CYP51 activity) and squalene synthase (an enzyme preceding CYP51 in the pathway) proteins have been studied. CYP51 was detected in step 3-19 spermatids, with large amounts in the cytoplasm/residual bodies of step 19 spermatids, where P450 reductase was also observed. Squalene synthase was immunodetected in step 2-15 spermatids of the rat, indicating that squalene synthase and CYP51 proteins are not equally expressed in same stages of spermatogenesis. Discordant expression of cholesterogenic genes may be a more general mechanism leading to transient accumulation of pathway intermediates in spermatogenesis. This study provides the first evidence that step 19 spermatids and residual bodies of the rat testis have the capacity to produce MAS sterols in situ.  (+info)

Identification of ligands and coligands for the ecdysone-regulated gene switch. (5/116)

The ecdysone-inducible gene switch is a useful tool for modulating gene expression in mammalian cells and transgenic animals. We have identified inducers derived from plants as well as certain classes of insecticides that increase the versatility of this gene regulation system. Phytoecdysteroids share the favorable kinetics of steroids, but are inert in mammals. The gene regulation properties of one of these ecdysteroids have been examined in cell culture and in newly developed strains of ecdysone-system transgenic mice. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly. A number of nonsteroidal insecticides have been identified that also activate the ecdysone system. Because the gene-controlling properties of the ecdysone switch are based on a heterodimer composed of a modified ecdysone receptor (VgEcR) and the retinoid X receptor (RXR), we have tested the effect of RXR ligands on the VgEcR/RXR complex. Used alone, RXR ligands display no activity on the ecdysone switch. However, when used in combination with a VgEcR ligand, RXR ligands dramatically enhance the absolute levels of induction. This property of the heterodimer has allowed the development of superinducer combinations that increase the dynamic range of the system.  (+info)

Meiosis-activating sterol and the maturation of isolated mouse oocytes. (6/116)

This study was carried out to examine the effects of the meiosis-activating C(29) sterol, 4,4-dimethyl-5 alpha-cholesta-8,14, 24-trien-3 beta-ol (FF-MAS), on mouse oocyte maturation in vitro. Cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) from hormonally primed, immature mice were cultured 17-18 h in minimum essential medium (MEM) containing 4 mM hypoxanthine plus increasing concentrations of FF-MAS. The sterol induced maturation in DO with an optimal concentration of 3 microg/ml but was without effect in CEO, even at concentrations as high as 10 microg/ml. Some stimulation of maturation in hypoxanthine-arrested CEO was observed when MEM was replaced by MEMalpha. Interestingly, the sterol suppressed the maturation of hypoxanthine-arrested CEO in MEM upon removal of glucose from the medium. FF-MAS also failed to induce maturation in DO when meiotic arrest was maintained with dibutyryl cAMP (dbcAMP). The rate of maturation in FF-MAS-stimulated, hypoxanthine-arrested DO was slow, as more than 6 h of culture elapsed before significant meiotic induction was observed, and this response required the continued presence of the sterol. Although the oocyte took up radiolabeled lanosterol, such accumulation was restricted by the presence of cumulus cells. In addition, lanosterol failed to augment FSH-induced maturation and was even inhibitory at a high concentration. Moreover, the downstream metabolite, cholesterol, augmented the inhibitory action of dbcAMP on maturation in both CEO and DO. Two inhibitors of 14 alpha-demethylase, ketoconazole, and 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol that can suppress FF-MAS production from lanosterol failed to block consistently FSH-induced maturation. These results confirm the stimulatory action of FF-MAS on hypoxanthine-arrested DO but do not support a universal meiosis-inducing function for this sterol.  (+info)

Activation of meiotic maturation in rat oocytes after treatment with follicular fluid meiosis-activating sterol in vitro and ex vivo. (7/116)

Meiosis-activating sterols (MAS) have been found to induce meiotic maturation in mouse oocytes in vitro. In the present study we have extended these observations by investigating the effects of follicular fluid MAS (FF-MAS) on rat oocyte maturation in vitro and ex vivo. Rat oocytes freed from their follicles were cultured with FF-MAS (0 microM, 1 microM, 3 microM, 10 microM, 30 microM) for 22 h in a medium containing the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX; 250 microM). A dose-dependent significant increase in germinal vesicle breakdown (GVB) was observed after adding FF-MAS to the culture medium in both cumulus-enclosed (CEO) and denuded (DO) oocytes. A time course study (0, 3, 8, 14, and 22 h) showed a significant increase in GVB after 14 h when DO and CEO were cultured in the presence of 10 microM FF-MAS + 250 microM IBMX. Furthermore immature rats were primed with eCG (20 IU) and 48 h later perfused ex vivo for 12 h in a recirculating system with either FF-MAS (0 microM, 10 microM, 30 microM, 60 microM), cholesterol (60 microM), or LH (0.2 microg/ml) in the presence of 200 microM IBMX, respectively. In addition, ovarian perfusion was carried out with FF-MAS (30 microM, 60 microM) or 0.2 microg/ml LH in the absence of IBMX. After 12 h, oocytes were freed from the ovaries and checked for GVB. By using the ex vivo perfused rat ovary, we found that FF-MAS, starting at 30 microM, was dose-dependently able to overcome IBMX-induced meiotic arrest leading to a comparable increase in GVB as was observed for LH. Furthermore, it was found that FF-MAS in the absence of IBMX was also able to induce meiotic maturation. Our data are consistent with the notion that the maturation-inducing effects of FF-MAS are mediated by different mechanisms compared to spontaneous maturation.  (+info)

Autoradiographic localization of specific binding of meiosis-activating sterol to cumulus-oocyte complexes from marmoset, cow, and mouse. (8/116)

The sterol, 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol (FF-MAS), isolated from human follicular fluid, can induce resumption of meiosis in denuded and cumulus-enclosed mouse oocytes inhibited by hypoxanthine, IBMX, or dibutyric cyclic adenosine monophosphate. In this study the distribution of FF-MAS binding sites in denuded oocytes and in cumulus-oocyte complexes (COCs) was studied using light microscopic (LM) and transmission electron microscopic (TEM) autoradiography in marmoset, cow, and mouse oocytes. Denuded (n = 39) and cumulus-enclosed (n = 28) marmoset, cow, and mouse oocytes were cultured in the presence of [3H]FF-MAS with and without excess of unlabeled FF-MAS, respectively. In denuded oocytes LM autoradiography demonstrated specific binding to the oolemma and zona pellucida and, to some extent, the cytoplasm. In the nucleus, no specific binding of [3H]FF-MAS was demonstrated. In some COCs the labeling was dispersed throughout the zona pellucida, the oolemma, and the cytoplasm as well as the cumulus cells; whereas in others, only the outer part of the cumulus cells were labeled. TEM autoradiograms of denuded cow oocytes (n = 6) demonstrated that specific [3H]FF-MAS binding was closely related to the oolemma and that a low level of [3H]FF-MAS binding to cumulus cell remnants was present. In conclusion, specific binding of FF-MAS is predominant at the oolemma of denuded oocytes, suggesting the existence of a plasma membrane-associated molecule with affinity for FF-MAS (i.e., a putative FF-MAS receptor).  (+info)

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Creative-Proteomics offer cas 516-55-2 5-ALPHA-PREGNAN-3-BETA-OL-20-ONE (17A,21,21,21-D4, 97%+) 96% PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
5$\alpha$-Cholest-8(14)-en-3$\beta$-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has been found to have significant hypocholesterolemic action upon oral administration to rodents and nonhuman primates. The metabolism of (2,4-$\sp3$H) 5$\alpha$-cholest-8(14)-3n-3$\beta$-ol-15-one was studied in Chinese hamster ovary (CHO-K1) cells. The incorporation of the labeled 15-ketosterol into the cells was linear with respect to sterol concentration in the medium over the range of concentrations studied and was higher than the uptake of cholesterol. The results of detailed analyses of the lipids recovered from the cells after 6 hours of incubation with the (2,4-$\sp3$H) -15-ketosterol indicated that most of the $\sp3$H was associated with the free 15-ketosterol. Considerably smaller amounts of $\sp3$H were associated with esters of the 15-ketosterol. No conversion of the 15-ketosterol to cholesterol or other C$\sb{27}$ monohydroxysterols was observed. The labeled material with the ...
Harsh conditions cause the nonparasitic Caenorhabditis elegans larvae to enter the developmentally arrested state of dauer, which requires a decrease in the steroid hormones Δ4-dafachronic acid (Δ4-DA) and Δ7-DA to release the nuclear hormone receptor DAF-12 from its ligand-bound state. Because dauer larvae share morphological similarities with infective larvae of parasitic nematodes, and because exit from dauer in C. elegans appears to use similar signaling mechanisms as activation of infectivity in the parasitic hookworm Ancylostoma caninum, Ogawa et al. reasoned that genes involved in inducing dauer might also be present in parasitic nematodes. They first examined whether Δ4-DA, Δ7-DA, and DAF-12 were involved in inducing dauer in Pristionchus pacificus, a nonparasitic distant relative of C. elegans. Unlike C. elegans, which only enters dauer under extreme conditions, P. pacificus must enter dauer as part of its life cycle and was considered by the authors to be an intermediate between ...
The oxysterol profile of the retina suggests that all known pathways of cholesterol elimination in extraocular organs are operative in the retina and that they likely vary depending on specific cell type. However, overall oxidation to 5-cholestenoic acid appears to be the predominant mechanism for c …
You are viewing an interactive 3D depiction of the molecule 14alpha-ethyl-5alpha-cholest-7-ene-3beta,15alpha-diol (C29H50O2) from the PQR.
산화제 주입이 유기물의 정성적인 특성에 미치는 영향을 파악하기 위하여 Chen 등이 제시한 방법[21]에 따라 Fluorescence excitation-emission matrix (FEEM) spectra 분석을 하였다. Fig. 1은 오존 주입량에 따른 FEEM의 변화를 나타낸다. 원수는 하수의 특성을 잘 나타내는 tyrosine-like proteins 부분과 soluble microbial products 부분에서 peak를 보였으며 fulvic acid-like substances와 humic acid-like substances 부분도 높은 peak를 나타냈다. 다만, tryptophan-like proteins 부분의 유기물은 적은 것으로 나타났다. 오존 주입량이 증가할수록 모든 영역에서 감소가 일어났고 특히 소수성 특성을 나타내는 humic acid-like와 fulvic acid-like 부분의 감소율이 가장 크게 나타났다. 염소 주입시에도 유사한 경향을 나타내어 산화제 주입량이 증가할수록 소수성 물질의 분해가 크게 나타났다. 그러나 이산화염소 처리수의 FEEM ...
New findings by researchers UT Southwestern Medical Center are accelerating efforts to eradicate worm infections that afflict a third of the worlds population.. The new findings, available online and in an upcoming issue of the Proceedings of the National Academy of Sciences, demonstrate that a biochemical system that controls development and reproduction of Caenorhabditis elegans, a common research worm, also provides the same function in several parasitic nematodes, including hookworm.. In these parasitic organisms, the activating molecule, called dafachronic acid, sends the necessary signals for the worms to mature from the stage in which they infect a host to the stage in which they start feeding on the host, which is what makes the host sick. In 2006 UT Southwestern scientists led by Dr. David Mangelsdorf, chairman of pharmacology at UT Southwestern and senior author of the new study in PNAS, had made the discovery in C elegans, a nematode about the size of a pinhead.. In the new study, ...
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Structure, properties, spectra, suppliers and links for: (3R,5R,6S,7S,9R,11E,13R,14R)-14-Ethyl-6-hydroxy-3,5,7,9,13-pentamethyloxacyclotetradec-11-ene-2,.
1-O-(rhamnopyranosyl-(1-2)-6-O-acetyl-galactopyranosyl)-1,3,22,26-tetrahydroxy-furost-5(6)-en-26-O-glucopyranoside: structure in first source
Shop for H.P.F Cholestene 600Mg Dietary Supplement Capsules With Red Yeast Rice - 120 Capsules from Heart Health. Browse other items form Cholestene Dietary Supplement
Rodrigues, M., et al. Proteolytic hydrolysis of cowpea proteins is able to release peptides with hypocholesterolemic activity. Food Research International. 77(1), 43-48. 20/04/2015.. ...
CAS: 15262-86-9 MF: C25H38O3 MW: 386.57 EINECS: 239-307-1 Synonyms: 17beta-hydroxyandrost-4-ene-3-one 4-methylvalerate;4-ANDROSTEN-17-BETA-OL-3-ONE ISOCAPROATE;4-ANDROSTEN-17BETA-OL-3-ONE ISOCAPRONATE;4-ANDROSTEN-17BETA-OL-3-ONE...
Products Testosterone Series Clostebol acetate/4-Chlorotestosterone Acetate Clostebol acetate (Steroids) Alias: 4-chlorotestosterone acetate; 4-chloroandrost-4-ene-17beta-ol-3-one acetate;Turinabol CAS NO.: 855-19-6 EINECS: 212-720-4 Assay: 98%...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
You are viewing an interactive 3D depiction of the molecule (6alpha,17alpha)-19-norpregna-1(10),2,4-trien-20-yne-3,6,17-triol (C20H24O3) from the PQR.
17-(N,N,-dimethylhydrazinocarbonyloxy)estra-1,3,5(10)-trien-3-ol: a synthetic estrogenic steroid; RN given refers to (17beta)-isomer
Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand for cholesterol, suggesting a possibility for metabolic interference. To test this idea in vivo, we ablated Nsdhl in adult keratinocytes expressing KRAS(G12D). Strikingly, Nsdhl inactivation antagonized the growth of skin tumors while having little effect on normal skin. Loss of Nsdhl induced the expression of ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, reduced the expression of low-density lipoprotein receptor (LDLR), decreased intracellular cholesterol, and was dependent on the liver X receptor (LXR) α. Importantly, EGFR signaling opposed LXRα effects on cholesterol homeostasis, whereas an EGFR inhibitor synergized with LXRα agonists in killing cancer cells. Inhibition of SC4MOL or NSDHL, or activation of LXRα by sterol metabolites, can ...
It is known that ceramides can influence the lateral organization in biological membranes. In particular ceramides have been shown to alter the composition of cholesterol and sphingolipid enriched nanoscopic domains, by displacing cholesterol, and forming gel phase domains with sphingomyelin. Here we have investigated how the bilayer content of ceramides and their chain length influence sterol partitioning into the membranes. The effect of ceramides with saturated chains ranging from 4 to 24 carbons in length was investigated. In addition, unsaturated 18:1- and 24:1-ceramides were also examined. The sterol partitioning into bilayer membranes was studied by measuring the distribution of cholestatrienol, a fluorescent cholesterol analogue, between methyl-beta-cyclodextrin and large unilamellar vesicle with defined lipid composition. Up to 15 mol% ceramide was added to bilayers composed of DOPC:PSM:cholesterol (3:1:1), and the effect on sterol partitioning was measured. Both at 23 and 37 degrees C ...
Thus, the two substrates of this enzyme are cholest-5-ene-3β,7α-diol and NAD+, whereas its 3 products are 7α-hydroxycholest-4-en-3-one, NADH, and H+. The systematic name of this enzyme class is cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 or HSD3B7 which is encoded by the HSD3B7 gene.[2][3] ...
Increasing evidence suggests that the various components of açaí contribute to cardioprotection via mechanisms that affect cell membrane receptors, intracellular signaling pathway proteins, and the modulation of gene expression [37],. [38], [39], [40] and [41]. It has been demonstrated that flavonoids regulate the activity of the Alisertib nuclear receptor regulators of cellular lipid metabolism [42] and [43]. The present study was designed to investigate the hypocholesterolemic activity of açaí pulp using a rat model of dietary-induced hypercholesterolemia. A 2% açaí pulp dose was chosen because of its relevance to human nutrition. This dosage mimics the addition of a portion of this fruit in food [44] and selleck compound has demonstrated effects in previous studies [10], [15] and [16]. Corroborating our previous results [15], açaí supplementation improved the lipid profile in the rat. Thus, we focused on characterizing the effects that açaí pulp supplementation in the diet would ...
The approach we used could be applied generally to any nematode parasite, not just this one type, said Dr. David Mangelsdorf, Chair of Pharmacology, an Investigator in the Howard Hughes Medical Institute (HHMI), and one of three corresponding authors of the study published in the Proceedings of the National Academy of Sciences. The studys other corresponding authors are at two universities in Philadelphia.. The plan is to develop better compounds that mimic the Δ7-dafachronic acid used in this study and eventually to treat the host to stop parasitic infection, he added.. The Centers for Disease Control and Prevention (CDC) reports that the soil-dwelling Strongyloides stercoralis nematode, or roundworm, is the primary strongyloides species that infects humans. Experts estimate that between 30 million and 100 million people are infected worldwide, and most of them are unaware of it because their symptoms are so mild. The parasite can persist for decades in the body because of the nematodes ...
The approach we used could be applied generally to any nematode parasite, not just this one type, said Dr. David Mangelsdorf, Chair of Pharmacology, an Investigator in the Howard Hughes Medical Institute (HHMI), and one of three corresponding authors of the study published in the Proceedings of the National Academy of Sciences. The studys other corresponding authors are at two universities in Philadelphia.. The plan is to develop better compounds that mimic the Δ7-dafachronic acid used in this study and eventually to treat the host to stop parasitic infection, he added.. The Centers for Disease Control and Prevention (CDC) reports that the soil-dwelling Strongyloides stercoralis nematode, or roundworm, is the primary strongyloides species that infects humans. Experts estimate that between 30 million and 100 million people are infected worldwide, and most of them are unaware of it because their symptoms are so mild. The parasite can persist for decades in the body because of the nematodes ...
Patterned after elements in landscapes by Peter Paul Rubens, the present painting gives currency to Delacroixs recommendation to Manet: Look at Rubens, draw inspiration from Rubens, copy Rubens. Rubens was God
Four new steroidal components (1−4) along with two known analogues (5−6) were obtained from the roots and rhizomes of Smilacina henryi. The components structures were determined as (25S)-5α-spirost-9(11)-ene-3β, 17α, 21-triol (1), (24S, 25S)-5α-spirost-9(11)-ene-3β, 17α, 24-triol (2), (25S)-5α-spirost-9(11)-ene-3β, 17α-dihydroxy-12-one (3), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione (4 ...
Age-Factors, Alcohol-Oxidoreductases: me, Animal, Animals-Newborn, Brain: en, gd, me, Carbon-Dioxide: me, Carbon-Isotopes, Fatty-Acids: bi, Female, Fetus: me, Genes-Recessive, Glutarates, Male, Mevalonic-Acid: me, Mice, Microsomes: en, me, Mutation, Phospholipids: bi, Sex-Chromosomes, Sterols: bi. ...
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
The nematode Caenorhabditis elegans is a genetically tractable model organism to investigate sterol transport. In vivo imaging of the fluorescent sterol, dehydroergosterol (DHE), is challenged by C. elegans high autofluorescence in the same spectral region as emission of DHE. We present a method to detect DHE selectively, based on its rapid bleaching kinetics compared to cellular autofluorescence. Worms were repeatedly imaged on an ultraviolet-sensitive wide field (UV-WF) microscope, and bleaching kinetics of DHE were fitted on a pixel-basis to mathematical models describing the intensity decay. Bleach-rate constants were determined for DHE in vivo and confirmed in model membranes. Using this method, we could detect enrichment of DHE in specific tissues like the nerve ring, the spermateca and oocytes. We confirm these results in C. elegans gut-granule-loss (glo) mutants with reduced autofluorescence and compare our method with three-photon excitation microscopy of sterol in selected tissues. Bleach
Testosterone Decanoate (Steroids) Synonyms: testosterone caproate;4-Androsten-17beta-ol-3-one Decanoate CAS: 5721-91-5 EINECS: 227-226-4 Mocular Formula: C29H46O3 Mocular weight:442.68 Moculare Structure: Assay: 98% min. Packing: foil bag or tin....
Connect with Dr. Jami Rubens, Radiology, Weston, MA. Video chat, send a message, ask a text question, or make a virtual appointment on the doctors Virtual Practice on HealthTap.
Dear chemists and other colleagues in science. Can someone please advise where I can obtain inokosterone? This is a steroid hormone derived from ecdysone and has the systematic name of: (2beta,3beta,14alpha,20R,22R,26-hexahydroxy-5beta-cholest-7-en-6-one). According to one reference (Hoppe-Seylers Z. Physiol. Chem. 359 1269, (1978)) Rohto Pharmaceuticals (Osaka, Japan) have supplied it previously. However, this company has not responded to fax enquiries. I need 5 to 10 milligrams of same for a start. Norman Gare (Dr) School of Biomedical Sciences Curtin University of Technology GPO Box U1987 PERTH WA 6001 cc: drosophila, parasitology ...
Catalog #: P2010002 - 250 U Cholesterol oxidase is a flavoprotein involved in the first step of cholesterol catabolism. The enzyme first oxidizes cholesterol to cholest-5-en-3-one then isomerizes it to cholest-4-en-3-one while producing hydrogen peroxide H2O2. Available in a 250 Units and custom bulk sizes. Live Enquiry about this product via Text/SMS: 1-858-900-3210 (8 am - 8 pm PST ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Jennifer Capriati a Key Biscayne-i tenisztorn n Ferrari-mezben p f lte a labd t, Rubens Barrichello Sao Paul ban panaszkodott a v r s k Forma-1-es
7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid biosynthesis. 7 alpha,26-Dihydroxy-4-cholesten-3-one is produced from 7 alpha,27-Dihydroxycholesterol through the action of HSD3B7 (EC:1.1.1.181). 7 alpha,26-Dihydroxy-4-cholesten-3-one can then be converted to 7 alpha-Hydroxy-3-oxo-4-cholestenoate by CYP27A (EC:1.14.13.15 ...
Studies have reported that guggulsterone has hypocholesterolemic activity. However, gugglesterone may also increase thyroid hormone levels.
Penicillium rubens ATCC ® 11709™ Designation: Wis. 49-133 [NRRL 2272] Application: Produces penicillin Transformations of uleine Pharmaceutical and Personal Care
InChI=1S/C27H42O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h14,16-17,20-24,29H,5-13,15H2,1-4H3,(H,30,31)/t16-,17?,20?,21?,22?,23-,24?,26+,27-/m1/ ...
Buy high quality (5α,17β)-N-Methoxy-N-methyl-3-oxo-4-azaandrost-1-ene-17-carboxamide 138689-15-3 from toronto research chemicals Inc.
Chris Rubens and Greg Hill recount here their efforts to decrease their personal impact on the environment. Its definitely worth a watch, and will hopefully get each of us thinking and acting in new ways.
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Antibodies for proteins involved in acylglycerol acyl-chain remodeling pathways, according to their Panther/Gene Ontology Classification
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
The title molecule, 2(R)-[(1E,3E,7S,8S,11E,13R)-13-hydroxy-4,8,12-trimethyl-7,8-epoxycyclotetradeca-1,3,11-trien-1-yl]propane-1,2… Expand ...
24) A comparative study on fluorescent cholesterol analogs as versatile cellular reporters (2016) Sezgin E, Can FB, Schneider F, Clausen MP, Galiani S, Stanly TA, Waithe D, Colaco A, Honigmann A, Wustner D, Platt F, Eggeling C. J Lipid Res 57: 299-309. 25) Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions (2016) Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C ACS Chem Biol 11:222-230. 26) Proteomic dataset of the sea urchin Paracentrotus lividus adhesive organs and secreted adhesive (2016) Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R. Data Brief 7: 1497-1505. 27) Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach (2016) Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R J Proteomics 138: ...
Rubens Oil Painting Reproductions- Nymphs filling the horn of plenty,Nymphs Filling the Horn Plenty and was little known to the art world at the time of his death,
The invention provides reagents and methods for multivalent binding and quantitative capture of components in a sample. In one aspect, reagents and methods for diagnostic assay for antigen, ligand, binding agent, or antibody are provided. Compositions of a non-natural or deliberately constructed nucleic acid-like polymeric scaffold are provided, to which multiple antibodies, peptides or other binding agents can be affixed by hybridization of a oligonucleotide: binding agent complex such that the nucleic acid: binding agent construction displays multivalent behavior when interacting with a multivalent analyte. Methods for constructing and using the scaffolds are described. Such compositions may include assembly of mixed specificity binding agents such that the composition displays multivalent binding behavior against a target containing mixed analytes which can be bound by the construct to effect a binding affinity increase such as is observed in avidity reagents against single analytes expressed
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Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 10322-03-9(Cholest-5-ene,3-butoxy-, (3b)-(9CI)),please inquire us for 10322-03-9(Cholest-5-ene,3-butoxy-, (3b)-(9CI)).
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Vol 70: 1-(3,4-Di-meth-oxy-phen-yl)-3-phenyl-prop-2-en-1-one.. This article is from Acta Crystallographica Section E: Structure Reports Online, volume 70.AbstractIn the title compound. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Cholestenes. *Cytochrome P-450 CYP2C8 Inhibitors. *Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) ...
Cholestenes. *Enzyme Inhibitors. *Lipids. *Membrane Lipids. *Molecular Mechanisms of Pharmacological Action. *Ophthalmologicals ...
Cholestenes [D04.808.247.222]. *Dihydrotachysterol [D04.808.247.222.387]. *Ergocalciferols [D04.808.247.222.474]. * ...
Cholestenes [D04.808.247.222]. *Cholecalciferol [D04.808.247.222.159]. *Hydroxycholecalciferols [D04.808.247.222.159.478]. * ...
glaucasterol: from soft coral Sarcophyton glaucum; natural C27 sterol with cyclopropane ring in side chain; structure given in first source
soy derived sterylglucoside mixture: a soy-bean derived mixture; contains 49.9% beta-sitosterol monoglucoside, 29.1% campesterol, 13.8% stigmasterol, and 7.2% brassicasterol; a potentially effective absorption enhancer for the nasal absorption of insulin
Categories: Cholestenes Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 4 ...
Purpose To develop a novel method for constructing a sheet of human corneal endothelial cells (HCECs) and examine the properties… Expand ...
Cholestenes [D04.808.247.222]. *Ergocalciferols [D04.808.247.222.474]. *Sterols [D04.808.247.808]. *Ergocalciferols [D04.808. ...
Cholestenes [D04.808.247.222]. *Cholecalciferol [D04.808.247.222.159]. *Hydroxycholecalciferols [D04.808.247.222.159.478]. * ...
Class Adjuvants; Cholestenes; Osteoporosis therapies; Small molecules; Sterols; Vitamin D analogues * Mechanism of Action ...
Cholestenes/metabolism. *Gas Chromatography-Mass Spectrometry. *Ligands. *Longevity/physiology*. *Magnetic Resonance ...
Cholestenes; sterol; Unclassified Ingredient Preparations =hydroxycholesterol; cholesterol oxide; SALICYLIC ACID 40% OINTMENT( ...
Achyranthes , Chemistry , Cholestenes , Chemistry , Ecdysterone , Chemistry , Molecular Structure , Plant Roots , Chemistry , ... Antineoplastic Agents , Chemistry , Pharmacology , Cell Line, Tumor , Cholestenes , Chemistry , Pharmacology , Cholesterol , ... Animals , Carcinoma, Hepatocellular , Metabolism , Pathology , Cations , Pharmacokinetics , Cell Line, Tumor , Cholestenes , ... 1,2-Dipalmitoylphosphatidylcholine , Pharmacokinetics , Animals , Area Under Curve , Cholestenes , Pharmacokinetics , ...
Cholestenes. *Cytochrome P-450 CYP3A Inducers. *Cytochrome P-450 CYP3A4 Inducers (weak) ...
cholestenes*human umbilical vein endothelial cells*2 naphthylamine*ginkgolides*scutellaria baicalensis*oligomycins*bornanes* ...
Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). Vitamin D has a major role in regulating calcium absorption from the gut, storage in mineral form in the bones, and excretion by the kidney and effectively prevents rickets in infants. Vitamin D and calcitriol can cause hypercalcemia at high or frequently repeated doses; in turn, hypercalcemia can cause kidney toxicity by accumulation of calcium-containing micro-crystals and heart and muscle dysfunction by impairing contractions. [Hybrigenics Website] The mechanism of action is currently unknown, but it is proposed that ...
Cholestenes ← Cholesterol 2.. Chemicals ← Polycyclic Compounds ← Fused-Ring Compounds ← Steroids ← Cholestanes ← Sterols ← ...
Antifungal Agents, pharmacology, Bacterial Proteins, Cholestenes, Electric Conductivity, Ion Channels, drug effects, physiology ...
Cells-Cultured, Cholestenes, Cholestenones, Fetus, Hydroxymethylglutaryl-CoA-Reductases: me, L-Cells: de, me, Liver: de, me, ...
Cholestenes D4.808.247.222 D4.210.500.247.222 Cholestenones D4.808.247.222.265 D4.210.500.247.222.265 Cholesterol D4.808. ...
The absence of cholest-4-ene, cholest-5-ene and cholestane suggests that cholestadiene reduction to cholestenes and cholestene ...
Cholestenes , Chemistry , Pharmacology , Cholesterol, VLDL , Blood , Disease Models, Animal , Ethanol , Toxicity , Female , ...
Définitions de Cholesterol, synonymes, antonymes, dérivés de Cholesterol, dictionnaire analogique de Cholesterol (anglais)
Aim of the study: administer to patients candidates for thyroidectomy for multinodular goiter cholecalciferol 50,000 IU per os a week, for 4 weeks before