Cholestenes: Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Anthozoa: A class in the phylum CNIDARIA, comprised mostly of corals and anemones. All members occur only as polyps; the medusa stage is completely absent.CyclopropanesDiterpenes: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.Pennisetum: A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.Mycolic AcidsStigmasterolPhytosterols: A class of organic compounds known as STEROLS or STEROIDS derived from plants.Sitosterols: A family of sterols commonly found in plants and plant oils. Alpha-, beta-, and gamma-isomers have been characterized.Hemibody Irradiation: Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called "systemic" hemibody irradiation with reference to its use in widespread cancer or metastases. (P. Rubin et al. Cancer, Vol 55, p2210, 1985)Cholestadienols: Cholestadiene derivatives containing a hydroxy group anywhere in the molecule.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)25-Hydroxyvitamin D3 1-alpha-Hydroxylase: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. (1/116)

Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is shown here that the human lung has a higher content of 27-hydroxycholesterol relative to cholesterol than any other organ. In order to evaluate the importance of the sterol 27-hydroxylase mechanism for cholesterol homeostasis in the lung, the production of cholestenoic acid by human lung was investigated. Removal of one lung reduced the level of cholestenoic acid in the circulation by 48 +/- 4% (P < 0.005). The levels of cholestenoic acid in the pulmonary artery and in the pulmonary vein showed significant differences (P < 0.002) with higher levels in the pulmonary vein (108 +/- 16 and 104 +/- 16 ng/mL, respectively). This corresponds to a net flux of cholestenoic acid from the lung of about 14 mg/day, which is more than 80% of the reported removal of this oxysterol and its metabolites from the circulation by the liver per day. Bypassing the lung for 60 min led to a reduction in circulating cholestenoic acid (30%) that fits with a pulmonary origin when taking into account the half-life of cholestenoic acid. The level of circulating cholestenoic acid was found to be less in patients with different lung diseases. It is evident that most of the cholestenoic acid in the circulation is of pulmonary origin. The present results suggest that the sterol 27-hydroxylase in the lung is responsible for at least half of the total flux of 27-oxygenated cholesterol metabolites to the liver and that this enzyme system may be of importance for cholesterol homeostasis in the lung.  (+info)

Meiosis-activating sterol-mediated resumption of meiosis in mouse oocytes in vitro is influenced by protein synthesis inhibition and cholera toxin. (2/116)

To explore the possible signaling pathways of meiosis-activating sterol (MAS)-induced oocyte maturation and to elucidate whether the MAS pathway involves transcription or translation, arrested immature mouse oocytes were cultured with either the protein synthesis inhibitor cycloheximide or the heteronuclear RNA inhibitors alpha-amanitin or actinomycin D, respectively. Moreover, the possible involvement of a G protein-coupled receptor mechanism in MAS-mediated oocyte maturation was explored by influencing oocyte maturation with cholera toxin (CT). MAS-induced oocyte maturation was completely blocked by the addition of 50 microg/ml cycloheximide 4 h before the addition of MAS. Simultaneous addition of MAS and the protein synthesis inhibitor also significantly reduced the meiotic resumption compared to that in MAS-treated controls. In contrast, neither of the treatment regimens to inhibit transcription of DNA to RNA was observed to have any effect on the MAS-induced resumption of meiosis. CT was observed to inhibit MAS-induced, but not spontaneous, oocyte maturation in vitro, suggesting a putative involvement of G protein-coupled receptor mechanism in the MAS mode of action. In conclusion, protein synthesis was found to be an essential requirement for maintaining the oocytes' responsiveness to MAS-induced resumption of meiosis, in contrast to transcription.  (+info)

Effect of inhibition of sterol delta 14-reductase on accumulation of meiosis-activating sterol and meiotic resumption in cumulus-enclosed mouse oocytes in vitro. (3/116)

Two sterols of the cholesterol biosynthetic pathway induce resumption of meiosis in mouse oocytes in vitro. The sterols, termed meiosis-activating sterols (MAS), have been isolated from human follicular fluid (FF-MAS, 4,4-dimethyl-5 alpha-cholest-8,14,24-triene-3 beta-ol) and from bull testicular tissue (T-MAS, 4,4-dimethyl-5 alpha-cholest-8,24-diene-3 beta-ol). FF-MAS is the first intermediate in the cholesterol biosynthesis from lanosterol and is converted to T-MAS by sterol delta 14-reductase. An inhibitor of delta 7-reductase and delta 14 reductase, AY9944-A-7, causes cells with a constitutive cholesterol biosynthesis to accumulate FF-MAS and possibly other intermediates between lanosterol and cholesterol. The aim of the present study was to evaluate whether AY9944-A-7 added to cultures of cumulus-oocyte complexes (COC) from mice resulted in accumulation of MAS and meiotic maturation. AY9944-A-7 stimulated dose dependently (5-25 mumol l-1) COC to resume meiosis when cultured for 22 h in alpha minimal essential medium (alpha-MEM) containing 4 mmol hypoxanthine l-1, a natural inhibitor of meiotic maturation. In contrast, naked oocytes were not induced to resume meiosis by AY9944-A-7. When cumulus cells were separated from their oocytes and co-cultured, AY9944-A-7 did not affect resumption of meiosis, indicating that intact oocyte-cumulus cell connections are important for AY9944-A-7 to exert its effect on meiosis. Cultures of COC with 10 mumol AY9944-A-7 l-1 in the presence of [3H]mevalonic acid, a natural precursor for steroid synthesis, resulted in accumulation of labelled FF-MAS, which had an 11-fold greater amount of radioactivity incorporated per COC compared with the control culture without AY9944-A-7. In contrast, incorporation of radioactivity into the cholesterol fraction was reduced 30-fold in extracts from the same oocytes. The present findings demonstrate for the first time that COC can synthesize cholesterol from mevalonate and accumulate FF-MAS in the presence of AY9944-A-7. Furthermore, AY9944-A-7 stimulated meiotic maturation dose dependently, indicating that FF-MAS, and possibly other sterol intermediates of the cholesterol synthesis pathway, play a central role in stimulating mouse oocytes to resume meiosis. The results also indicate that oocytes may not synthesize steroids from mevalonate.  (+info)

Lanosterol 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol. (4/116)

Lanosterol 14alpha-demethylase (CYP51) is a cytochrome P450 enzyme involved primarily in cholesterol biosynthesis. CYP51 in the presence of NADPH-cytochrome P450 reductase converts lanosterol to follicular fluid meiosis activating sterol (FF-MAS), an intermediate of cholesterol biosynthesis which accumulates in gonads and has an additional function as oocyte meiosis-activating substance. This work shows for the first time that cholesterogenic enzymes are highly expressed only in distinct stages of spermatogenesis. CYP51, NADPH-P450 reductase (the electron transferring enzyme needed for CYP51 activity) and squalene synthase (an enzyme preceding CYP51 in the pathway) proteins have been studied. CYP51 was detected in step 3-19 spermatids, with large amounts in the cytoplasm/residual bodies of step 19 spermatids, where P450 reductase was also observed. Squalene synthase was immunodetected in step 2-15 spermatids of the rat, indicating that squalene synthase and CYP51 proteins are not equally expressed in same stages of spermatogenesis. Discordant expression of cholesterogenic genes may be a more general mechanism leading to transient accumulation of pathway intermediates in spermatogenesis. This study provides the first evidence that step 19 spermatids and residual bodies of the rat testis have the capacity to produce MAS sterols in situ.  (+info)

Identification of ligands and coligands for the ecdysone-regulated gene switch. (5/116)

The ecdysone-inducible gene switch is a useful tool for modulating gene expression in mammalian cells and transgenic animals. We have identified inducers derived from plants as well as certain classes of insecticides that increase the versatility of this gene regulation system. Phytoecdysteroids share the favorable kinetics of steroids, but are inert in mammals. The gene regulation properties of one of these ecdysteroids have been examined in cell culture and in newly developed strains of ecdysone-system transgenic mice. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly. A number of nonsteroidal insecticides have been identified that also activate the ecdysone system. Because the gene-controlling properties of the ecdysone switch are based on a heterodimer composed of a modified ecdysone receptor (VgEcR) and the retinoid X receptor (RXR), we have tested the effect of RXR ligands on the VgEcR/RXR complex. Used alone, RXR ligands display no activity on the ecdysone switch. However, when used in combination with a VgEcR ligand, RXR ligands dramatically enhance the absolute levels of induction. This property of the heterodimer has allowed the development of superinducer combinations that increase the dynamic range of the system.  (+info)

Meiosis-activating sterol and the maturation of isolated mouse oocytes. (6/116)

This study was carried out to examine the effects of the meiosis-activating C(29) sterol, 4,4-dimethyl-5 alpha-cholesta-8,14, 24-trien-3 beta-ol (FF-MAS), on mouse oocyte maturation in vitro. Cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) from hormonally primed, immature mice were cultured 17-18 h in minimum essential medium (MEM) containing 4 mM hypoxanthine plus increasing concentrations of FF-MAS. The sterol induced maturation in DO with an optimal concentration of 3 microg/ml but was without effect in CEO, even at concentrations as high as 10 microg/ml. Some stimulation of maturation in hypoxanthine-arrested CEO was observed when MEM was replaced by MEMalpha. Interestingly, the sterol suppressed the maturation of hypoxanthine-arrested CEO in MEM upon removal of glucose from the medium. FF-MAS also failed to induce maturation in DO when meiotic arrest was maintained with dibutyryl cAMP (dbcAMP). The rate of maturation in FF-MAS-stimulated, hypoxanthine-arrested DO was slow, as more than 6 h of culture elapsed before significant meiotic induction was observed, and this response required the continued presence of the sterol. Although the oocyte took up radiolabeled lanosterol, such accumulation was restricted by the presence of cumulus cells. In addition, lanosterol failed to augment FSH-induced maturation and was even inhibitory at a high concentration. Moreover, the downstream metabolite, cholesterol, augmented the inhibitory action of dbcAMP on maturation in both CEO and DO. Two inhibitors of 14 alpha-demethylase, ketoconazole, and 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol that can suppress FF-MAS production from lanosterol failed to block consistently FSH-induced maturation. These results confirm the stimulatory action of FF-MAS on hypoxanthine-arrested DO but do not support a universal meiosis-inducing function for this sterol.  (+info)

Activation of meiotic maturation in rat oocytes after treatment with follicular fluid meiosis-activating sterol in vitro and ex vivo. (7/116)

Meiosis-activating sterols (MAS) have been found to induce meiotic maturation in mouse oocytes in vitro. In the present study we have extended these observations by investigating the effects of follicular fluid MAS (FF-MAS) on rat oocyte maturation in vitro and ex vivo. Rat oocytes freed from their follicles were cultured with FF-MAS (0 microM, 1 microM, 3 microM, 10 microM, 30 microM) for 22 h in a medium containing the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX; 250 microM). A dose-dependent significant increase in germinal vesicle breakdown (GVB) was observed after adding FF-MAS to the culture medium in both cumulus-enclosed (CEO) and denuded (DO) oocytes. A time course study (0, 3, 8, 14, and 22 h) showed a significant increase in GVB after 14 h when DO and CEO were cultured in the presence of 10 microM FF-MAS + 250 microM IBMX. Furthermore immature rats were primed with eCG (20 IU) and 48 h later perfused ex vivo for 12 h in a recirculating system with either FF-MAS (0 microM, 10 microM, 30 microM, 60 microM), cholesterol (60 microM), or LH (0.2 microg/ml) in the presence of 200 microM IBMX, respectively. In addition, ovarian perfusion was carried out with FF-MAS (30 microM, 60 microM) or 0.2 microg/ml LH in the absence of IBMX. After 12 h, oocytes were freed from the ovaries and checked for GVB. By using the ex vivo perfused rat ovary, we found that FF-MAS, starting at 30 microM, was dose-dependently able to overcome IBMX-induced meiotic arrest leading to a comparable increase in GVB as was observed for LH. Furthermore, it was found that FF-MAS in the absence of IBMX was also able to induce meiotic maturation. Our data are consistent with the notion that the maturation-inducing effects of FF-MAS are mediated by different mechanisms compared to spontaneous maturation.  (+info)

Autoradiographic localization of specific binding of meiosis-activating sterol to cumulus-oocyte complexes from marmoset, cow, and mouse. (8/116)

The sterol, 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol (FF-MAS), isolated from human follicular fluid, can induce resumption of meiosis in denuded and cumulus-enclosed mouse oocytes inhibited by hypoxanthine, IBMX, or dibutyric cyclic adenosine monophosphate. In this study the distribution of FF-MAS binding sites in denuded oocytes and in cumulus-oocyte complexes (COCs) was studied using light microscopic (LM) and transmission electron microscopic (TEM) autoradiography in marmoset, cow, and mouse oocytes. Denuded (n = 39) and cumulus-enclosed (n = 28) marmoset, cow, and mouse oocytes were cultured in the presence of [3H]FF-MAS with and without excess of unlabeled FF-MAS, respectively. In denuded oocytes LM autoradiography demonstrated specific binding to the oolemma and zona pellucida and, to some extent, the cytoplasm. In the nucleus, no specific binding of [3H]FF-MAS was demonstrated. In some COCs the labeling was dispersed throughout the zona pellucida, the oolemma, and the cytoplasm as well as the cumulus cells; whereas in others, only the outer part of the cumulus cells were labeled. TEM autoradiograms of denuded cow oocytes (n = 6) demonstrated that specific [3H]FF-MAS binding was closely related to the oolemma and that a low level of [3H]FF-MAS binding to cumulus cell remnants was present. In conclusion, specific binding of FF-MAS is predominant at the oolemma of denuded oocytes, suggesting the existence of a plasma membrane-associated molecule with affinity for FF-MAS (i.e., a putative FF-MAS receptor).  (+info)

*Cholestene

Cholestenes are derivatives of cholestanes that have a double bond. If there are two double bonds, the molecule is known as a " ... Red yeast rice Cholestenes at the US National Library of Medicine Medical Subject Headings (MeSH) PubChem - 5-Cholestene ...

*Cholestane

Derivatives are classified in two families: Sterols (with an alcohol group) Cholestenes (with a double bond) Some steroids, ...

*List of MeSH codes (D04)

... cholestenes MeSH D04.808.247.222.159 --- cholecalciferol MeSH D04.808.247.222.159.478 --- hydroxycholecalciferols MeSH D04.808. ...
Healthy Origins, HPF Cholestene, 120 Capsules. For all your vitamins, superfoods and nutritional supplements. Lowest prices, fast delivery and Webshop
Creative-Proteomics offer cas 516-55-2 5-ALPHA-PREGNAN-3-BETA-OL-20-ONE (17A,21,21,21-D4, 97%+) 96% PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
5$\alpha$-Cholest-8(14)-en-3$\beta$-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has been found to have significant hypocholesterolemic action upon oral administration to rodents and nonhuman primates. The metabolism of (2,4-$\sp3$H) 5$\alpha$-cholest-8(14)-3n-3$\beta$-ol-15-one was studied in Chinese hamster ovary (CHO-K1) cells. The incorporation of the labeled 15-ketosterol into the cells was linear with respect to sterol concentration in the medium over the range of concentrations studied and was higher than the uptake of cholesterol. The results of detailed analyses of the lipids recovered from the cells after 6 hours of incubation with the (2,4-$\sp3$H) -15-ketosterol indicated that most of the $\sp3$H was associated with the free 15-ketosterol. Considerably smaller amounts of $\sp3$H were associated with esters of the 15-ketosterol. No conversion of the 15-ketosterol to cholesterol or other C$\sb{27}$ monohydroxysterols was observed. The labeled material with the ...
You are viewing an interactive 3D depiction of the molecule 14alpha-ethyl-5alpha-cholest-7-ene-3beta,15alpha-diol (C29H50O2) from the PQR.
New findings by researchers UT Southwestern Medical Center are accelerating efforts to eradicate worm infections that afflict a third of the worlds population.. The new findings, available online and in an upcoming issue of the Proceedings of the National Academy of Sciences, demonstrate that a biochemical system that controls development and reproduction of Caenorhabditis elegans, a common research worm, also provides the same function in several parasitic nematodes, including hookworm.. In these parasitic organisms, the activating molecule, called dafachronic acid, sends the necessary signals for the worms to mature from the stage in which they infect a host to the stage in which they start feeding on the host, which is what makes the host sick. In 2006 UT Southwestern scientists led by Dr. David Mangelsdorf, chairman of pharmacology at UT Southwestern and senior author of the new study in PNAS, had made the discovery in C elegans, a nematode about the size of a pinhead.. In the new study, ...
Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.. ...
Shop for H.P.F Cholestene 600Mg Dietary Supplement Capsules With Red Yeast Rice - 120 Capsules from Heart Health. Browse other items form Cholestene Dietary Supplement
Rodrigues, M., et al. Proteolytic hydrolysis of cowpea proteins is able to release peptides with hypocholesterolemic activity. Food Research International. 77(1), 43-48. 20/04/2015.. ...
CAS: 15262-86-9 MF: C25H38O3 MW: 386.57 EINECS: 239-307-1 Synonyms: 17beta-hydroxyandrost-4-ene-3-one 4-methylvalerate;4-ANDROSTEN-17-BETA-OL-3-ONE ISOCAPROATE;4-ANDROSTEN-17BETA-OL-3-ONE ISOCAPRONATE;4-ANDROSTEN-17BETA-OL-3-ONE...
Products Testosterone Series Clostebol acetate/4-Chlorotestosterone Acetate Clostebol acetate (Steroids) Alias: 4-chlorotestosterone acetate; 4-chloroandrost-4-ene-17beta-ol-3-one acetate;Turinabol CAS NO.: 855-19-6 EINECS: 212-720-4 Assay: 98%...
You are viewing an interactive 3D depiction of the molecule (6alpha,17alpha)-19-norpregna-1(10),2,4-trien-20-yne-3,6,17-triol (C20H24O3) from the PQR.
Meiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand for cholesterol, suggesting a possibility for metabolic interference. To test this idea in vivo, we ablated Nsdhl in adult keratinocytes expressing KRAS(G12D). Strikingly, Nsdhl inactivation antagonized the growth of skin tumors while having little effect on normal skin. Loss of Nsdhl induced the expression of ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, reduced the expression of low-density lipoprotein receptor (LDLR), decreased intracellular cholesterol, and was dependent on the liver X receptor (LXR) α. Importantly, EGFR signaling opposed LXRα effects on cholesterol homeostasis, whereas an EGFR inhibitor synergized with LXRα agonists in killing cancer cells. Inhibition of SC4MOL or NSDHL, or activation of LXRα by sterol metabolites, can ...
It is known that ceramides can influence the lateral organization in biological membranes. In particular ceramides have been shown to alter the composition of cholesterol and sphingolipid enriched nanoscopic domains, by displacing cholesterol, and forming gel phase domains with sphingomyelin. Here we have investigated how the bilayer content of ceramides and their chain length influence sterol partitioning into the membranes. The effect of ceramides with saturated chains ranging from 4 to 24 carbons in length was investigated. In addition, unsaturated 18:1- and 24:1-ceramides were also examined. The sterol partitioning into bilayer membranes was studied by measuring the distribution of cholestatrienol, a fluorescent cholesterol analogue, between methyl-beta-cyclodextrin and large unilamellar vesicle with defined lipid composition. Up to 15 mol% ceramide was added to bilayers composed of DOPC:PSM:cholesterol (3:1:1), and the effect on sterol partitioning was measured. Both at 23 and 37 degrees C ...
Increasing evidence suggests that the various components of açaí contribute to cardioprotection via mechanisms that affect cell membrane receptors, intracellular signaling pathway proteins, and the modulation of gene expression [37],. [38], [39], [40] and [41]. It has been demonstrated that flavonoids regulate the activity of the Alisertib nuclear receptor regulators of cellular lipid metabolism [42] and [43]. The present study was designed to investigate the hypocholesterolemic activity of açaí pulp using a rat model of dietary-induced hypercholesterolemia. A 2% açaí pulp dose was chosen because of its relevance to human nutrition. This dosage mimics the addition of a portion of this fruit in food [44] and selleck compound has demonstrated effects in previous studies [10], [15] and [16]. Corroborating our previous results [15], açaí supplementation improved the lipid profile in the rat. Thus, we focused on characterizing the effects that açaí pulp supplementation in the diet would ...
The approach we used could be applied generally to any nematode parasite, not just this one type," said Dr. David Mangelsdorf, Chair of Pharmacology, an Investigator in the Howard Hughes Medical Institute (HHMI), and one of three corresponding authors of the study published in the Proceedings of the National Academy of Sciences. The studys other corresponding authors are at two universities in Philadelphia.. "The plan is to develop better compounds that mimic the Δ7-dafachronic acid used in this study and eventually to treat the host to stop parasitic infection," he added.. The Centers for Disease Control and Prevention (CDC) reports that the soil-dwelling Strongyloides stercoralis nematode, or roundworm, is the primary strongyloides species that infects humans. Experts estimate that between 30 million and 100 million people are infected worldwide, and most of them are unaware of it because their symptoms are so mild. The parasite can persist for decades in the body because of the nematodes ...
The approach we used could be applied generally to any nematode parasite, not just this one type," said Dr. David Mangelsdorf, Chair of Pharmacology, an Investigator in the Howard Hughes Medical Institute (HHMI), and one of three corresponding authors of the study published in the Proceedings of the National Academy of Sciences. The studys other corresponding authors are at two universities in Philadelphia.. "The plan is to develop better compounds that mimic the Δ7-dafachronic acid used in this study and eventually to treat the host to stop parasitic infection," he added.. The Centers for Disease Control and Prevention (CDC) reports that the soil-dwelling Strongyloides stercoralis nematode, or roundworm, is the primary strongyloides species that infects humans. Experts estimate that between 30 million and 100 million people are infected worldwide, and most of them are unaware of it because their symptoms are so mild. The parasite can persist for decades in the body because of the nematodes ...
Patterned after elements in landscapes by Peter Paul Rubens, the present painting gives currency to Delacroixs recommendation to Manet: Look at Rubens, draw inspiration from Rubens, copy Rubens. Rubens was God
Four new steroidal components (1−4) along with two known analogues (5−6) were obtained from the roots and rhizomes of Smilacina henryi. The components structures were determined as (25S)-5α-spirost-9(11)-ene-3β, 17α, 21-triol (1), (24S, 25S)-5α-spirost-9(11)-ene-3β, 17α, 24-triol (2), (25S)-5α-spirost-9(11)-ene-3β, 17α-dihydroxy-12-one (3), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione (4 ...
Age-Factors, Alcohol-Oxidoreductases: me, Animal, Animals-Newborn, Brain: en, gd, me, Carbon-Dioxide: me, Carbon-Isotopes, Fatty-Acids: bi, Female, Fetus: me, Genes-Recessive, Glutarates, Male, Mevalonic-Acid: me, Mice, Microsomes: en, me, Mutation, Phospholipids: bi, Sex-Chromosomes, Sterols: bi. ...
Testosterone Decanoate (Steroids) Synonyms: testosterone caproate;4-Androsten-17beta-ol-3-one Decanoate CAS: 5721-91-5 EINECS: 227-226-4 Mocular Formula: C29H46O3 Mocular weight:442.68 Moculare Structure: Assay: 98% min. Packing: foil bag or tin....
Dear chemists and other colleagues in science. Can someone please advise where I can obtain inokosterone? This is a steroid hormone derived from ecdysone and has the systematic name of: (2beta,3beta,14alpha,20R,22R,26-hexahydroxy-5beta-cholest-7-en-6-one). According to one reference (Hoppe-Seylers Z. Physiol. Chem. 359 1269, (1978)) Rohto Pharmaceuticals (Osaka, Japan) have supplied it previously. However, this company has not responded to fax enquiries. I need 5 to 10 milligrams of same for a start. Norman Gare (Dr) School of Biomedical Sciences Curtin University of Technology GPO Box U1987 PERTH WA 6001 cc: drosophila, parasitology ...
Catalog #: P2010002 - 250 U Cholesterol oxidase is a flavoprotein involved in the first step of cholesterol catabolism. The enzyme first oxidizes cholesterol to cholest-5-en-3-one then isomerizes it to cholest-4-en-3-one while producing hydrogen peroxide H2O2. Available in a 250 Units and custom bulk sizes. Live Enquiry about this product via Text/SMS: 1-858-900-3210 (8 am - 8 pm PST ...
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7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid biosynthesis. 7 alpha,26-Dihydroxy-4-cholesten-3-one is produced from 7 alpha,27-Dihydroxycholesterol through the action of HSD3B7 (EC:1.1.1.181). 7 alpha,26-Dihydroxy-4-cholesten-3-one can then be converted to 7 alpha-Hydroxy-3-oxo-4-cholestenoate by CYP27A (EC:1.14.13.15 ...
Studies have reported that guggulsterone has hypocholesterolemic activity. However, gugglesterone may also increase thyroid hormone levels.
Penicillium rubens ATCC ® 11709™ Designation: Wis. 49-133 [NRRL 2272] Application: Produces penicillin Transformations of uleine Pharmaceutical and Personal Care
InChI=1S/C27H42O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h14,16-17,20-24,29H,5-13,15H2,1-4H3,(H,30,31)/t16-,17?,20?,21?,22?,23-,24?,26+,27-/m1/ ...
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Chris Rubens and Greg Hill recount here their efforts to decrease their personal impact on the environment. Its definitely worth a watch, and will hopefully get each of us thinking and acting in new ways.
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24) A comparative study on fluorescent cholesterol analogs as versatile cellular reporters (2016) Sezgin E, Can FB, Schneider F, Clausen MP, Galiani S, Stanly TA, Waithe D, Colaco A, Honigmann A, Wustner D, Platt F, Eggeling C. J Lipid Res 57: 299-309. 25) Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions (2016) Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C ACS Chem Biol 11:222-230. 26) Proteomic dataset of the sea urchin Paracentrotus lividus adhesive organs and secreted adhesive (2016) Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R. Data Brief 7: 1497-1505. 27) Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach (2016) Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R J Proteomics 138: ...
The invention provides reagents and methods for multivalent binding and quantitative capture of components in a sample. In one aspect, reagents and methods for diagnostic assay for antigen, ligand, binding agent, or antibody are provided. Compositions of a non-natural or deliberately constructed nucleic acid-like polymeric scaffold are provided, to which multiple antibodies, peptides or other binding agents can be affixed by hybridization of a oligonucleotide: binding agent complex such that the nucleic acid: binding agent construction displays multivalent behavior when interacting with a multivalent analyte. Methods for constructing and using the scaffolds are described. Such compositions may include assembly of mixed specificity binding agents such that the composition displays multivalent binding behavior against a target containing mixed analytes which can be bound by the construct to effect a binding affinity increase such as is observed in avidity reagents against single analytes expressed
Skin After Age 40. Your skins natural abilities to fight UV radiation and pollutants decrease rapidly. Skin begins to sag; fine lines and wrinkles appear; collagen production decreases; moisture levels decrease. The answer: Supercharge your bodys natural skin defenses with YEOUTH Anti-Aging Super Serum and restore your skin to a younger, more radiant state.. How YEOUTH Anti-Aging Super Serum Works. Free Radical-Fighting Ferulic Acid. Found naturally in fruits, Ferulic Acid is a super antioxidant. Combined with Vitamins C and E, it increases the efficacy of the Vitamin C eight-fold, reducing the effects of chronic sun damage to skin.. Moisture-Attracting Hyaluronic Acid. Hyaluronic Acid is a naturally-occurring compound in your skin. It attracts and holds water molecules. Hyaluronic Acid holds up to 1,000 times its weight in water. It plumps and evens out crevices, providing supple, smooth skin.. Collagen-Boosting Tripeptide-31. Powerful retinoic acid-like Tripeptide-31 reverses age-related ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 10322-03-9(Cholest-5-ene,3-butoxy-, (3b)-(9CI)),please inquire us for 10322-03-9(Cholest-5-ene,3-butoxy-, (3b)-(9CI)).
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Vol 70: 1-(3,4-Di-meth-oxy-phen-yl)-3-phenyl-prop-2-en-1-one.. This article is from Acta Crystallographica Section E: Structure Reports Online, volume 70.AbstractIn the title compound. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Petroz.. Acts upon the cerebro-spinal system, giving readily and often in profusion symptoms indicating disturbance of function, but it never goes on to alteration of tissue, rarely even to the earliest indications thereof.. Its general tendency is to produce irritation and congestion of venous parts, never reaching true inflammation.. Characteristic symptoms.. Mind.- (Asterias rubens). Very sensitive ; weeping ; melancholy ; depressed ; irritable.. Head.- (Asterias rubens). Vertigo.. Heat of the head, as if surrounded by hot air.. Sense of fullness, and rush of blood to the head.. Throbbing in the head.. Sensation as if the brain were receiving shocks from an electric battery ; head felt as if bursting ; consciousness almost extinct ; hard pulse, and throbbing of right carotid. (Bell.). Pressive and lancinating pains in temples and elsewhere.. Eyes.- (Asterias rubens). Eyes bloodshot, and feel hot. (Acon., Bell.). Fatigued look ; light fatigues the eyes.. Face.- (Asterias rubens). Redness of ...
Compounds that block hepatic cholesterol biosynthesis and secretion may be useful hypocholesterolemic agents. N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815) has been shown to block cholesterol biosynthesis in 3T3 fibroblasts and it causes cellular accumulation of squalene 2,3-epoxide and squalene 2,3:23,24-diepoxide (squalene epoxides), which suggests that it inhibits 2,3-oxidosqualene cyclase. The purpose of the present report was to determine whether MDL 28,815 acts only at the level of 2,3-oxidosqualene cyclase or whether other enzymes in the cholesterol biosynthetic pathway are affected. HepG2 cells, grown in lipoprotein-deficient serum, were incubated with MDL 28,815 and 14C-acetate to radiolabel cholesterol and the intermediates in the cholesterol biosynthetic pathway. Blockade of cholesterol biosynthesis by MDL 28,815 in these cells was associated with the accumulation of two metabolites, one of which was 5 alpha-cholest-8-en-3 beta-ol. The other ...
To have a Darco mare nowadays is worth money. Darco has been the best showjumping horse supplier in the world for six years on end. To cross one of his daughters with the stallion of the future cannot but produce a sensational result. Sire Comme Il Faut, the son of Cornet Obolensky and Ratina Z, recently broke through in the sport under Marcus Ehning with a third place in the Rotterdam Grand Prix. Dam Esprit de Laubry is a product from one of the best families in Belgium. This is the line of Nikita de Laubry. She also supplied Baltimore, Withney vd Dwerse Hagen, Fantomas de Muze, Premium de Laubry, Rubens du Ry DAsse, Dinero de Laubry, as well as Allouette and Ti Amo van t Lambroeck ...

RCSB PDB - FUA Ligand Summary PageRCSB PDB - FUA Ligand Summary Page

Cholestenes. *Enzyme Inhibitors. *Lipids. *Membrane Lipids. *Molecular Mechanisms of Pharmacological Action. *Ophthalmologicals ...
more infohttp://www.rcsb.org/ligand/FUA

glaucasterol
     Summary Report | CureHunterglaucasterol Summary Report | CureHunter

glaucasterol: from soft coral Sarcophyton glaucum; natural C27 sterol with cyclopropane ring in side chain; structure given in first source
more infohttp://www.curehunter.com/public/keywordSummaryC040181-glaucasterol.do

soy derived sterylglucoside mixture
     Summary Report | CureHuntersoy derived sterylglucoside mixture Summary Report | CureHunter

soy derived sterylglucoside mixture: a soy-bean derived mixture; contains 49.9% beta-sitosterol monoglucoside, 29.1% campesterol, 13.8% stigmasterol, and 7.2% brassicasterol; a potentially effective absorption enhancer for the nasal absorption of insulin
more infohttp://www.curehunter.com/public/keywordSummaryC096056-soy-derived-sterylglucoside-mixture.do

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Cholestenes Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 4 ...
more infohttps://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Cholestenes&parentid=6193&catid=6200

Ergocalciferols | Profiles RNSErgocalciferols | Profiles RNS

Cholestenes [D04.808.247.222]. *Ergocalciferols [D04.808.247.222.474]. *Sterols [D04.808.247.808]. *Ergocalciferols [D04.808. ...
more infohttps://profiles.umassmed.edu/display/120287

Cholestene - WikipediaCholestene - Wikipedia

Cholestenes are derivatives of cholestanes that have a double bond. If there are two double bonds, the molecule is known as a " ... Red yeast rice Cholestenes at the US National Library of Medicine Medical Subject Headings (MeSH) PubChem - 5-Cholestene ...
more infohttps://en.wikipedia.org/wiki/Cholestene

Colecalciferol - Abiogen Pharma - AdisInsightColecalciferol - Abiogen Pharma - AdisInsight

Class Adjuvants; Cholestenes; Osteoporosis therapies; Small molecules; Sterols; Vitamin D analogues * Mechanism of Action ...
more infohttps://adisinsight.springer.com/drugs/800041217?error=cookies_not_supported&code=3667b1b9-3ecc-427f-a6ee-c3f9b90b6b00

Terms defined in UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - MEDINDEX.AMTerms defined in 'UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM' - MEDINDEX.AM

Cholestenes; sterol; Unclassified Ingredient Preparations =hydroxycholesterol; cholesterol oxide; SALICYLIC ACID 40% OINTMENT( ...
more infohttp://www.medindex.am/glossary/index.php/list/UMLS.+CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM/1.xhtml

Cholestane - WikipediaCholestane - Wikipedia

Derivatives are classified in two families: Sterols (with an alcohol group) Cholestenes (with a double bond) Some steroids, ...
more infohttps://en.wikipedia.org/wiki/Cholestane

NAVER Academic > Search...NAVER Academic > Search...

Antifungal Agents, pharmacology, Bacterial Proteins, Cholestenes, Electric Conductivity, Ion Channels, drug effects, physiology ...
more infohttps://academic.naver.com/search.naver?field=3&query=Biochimica+et+Biophysica+Acta+1324%EA%B6%8C+1%ED%98%B8

Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development...Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development...

Cholestenes/metabolism. *Gas Chromatography-Mass Spectrometry. *Ligands. *Longevity/physiology*. *Magnetic Resonance ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24411940

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-s by G J. Schroepfer, E J. Parish et al.Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-s" by G J. Schroepfer, E J. Parish et al.

Cells-Cultured, Cholestenes, Cholestenones, Fetus, Hydroxymethylglutaryl-CoA-Reductases: me, L-Cells: de, me, Liver: de, me, ...
more infohttps://mouseion.jax.org/stfb1970_1979/983/

Calcitriol - DrugBankCalcitriol - DrugBank

Cholestenes. *Cytochrome P-450 CYP3A Inducers. *Cytochrome P-450 CYP3A4 Inducers (weak) ...
more infohttps://www.drugbank.ca/drugs/DB00136

Experts and Doctors on protein kinase c in Beijing, ChinaExperts and Doctors on protein kinase c in Beijing, China

cholestenes*human umbilical vein endothelial cells*2 naphthylamine*ginkgolides*scutellaria baicalensis*oligomycins*bornanes* ...
more infohttp://www.labome.org/locale/china/experts-and-doctors-on-protein-kinase-c-in-beijing--china-30592.html

Ergosterol - DrugBankErgosterol - DrugBank

A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
more infohttps://www.drugbank.ca/drugs/DB04038

Cholesterol | CTDCholesterol | CTD

Cholestenes ← Cholesterol 2.. Chemicals ← Polycyclic Compounds ← Fused-Ring Compounds ← Steroids ← Cholestanes ← Sterols ← ...
more infohttp://ctd.mdibl.org/detail.go?type=chem&acc=D002784

Ergocalciferols | CTDErgocalciferols | CTD

Cholestenes ← Ergocalciferols 2.. Chemicals ← Polycyclic Compounds ← Fused-Ring Compounds ← Steroids ← Cholestanes ← Sterols ← ...
more infohttp://ctdbase.org/detail.go?type=chem&acc=D004872

Cholesterol : définition de Cholesterol et synonymes de Cholesterol (anglais)Cholesterol : définition de Cholesterol et synonymes de Cholesterol (anglais)

Définitions de Cholesterol, synonymes, antonymes, dérivés de Cholesterol, dictionnaire analogique de Cholesterol (anglais)
more infohttp://dictionnaire.sensagent.leparisien.fr/Cholesterol/en-en/

DeCS Ingl sDeCS Ingl s

D04.210.500.247.222 Cholestenes .. D04.210.500.247.222.265 Cholestenones .. D04.210.500.247.222.265.165 Ecdysteroids .. D04.210 ...
more infohttp://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSi&lang=p&minsim=0.30&maxrel=10&text=20-Hydroxyecdysone

chI, Ch D, Ch B, CH, Online Medical Terminology Catalogch'I, Ch D, Ch B, CH, Online Medical Terminology Catalog

chI, Ch D, Ch B, CH, Online Electronic Medical Dictionary Terminology, Articles, Glossary
more infohttps://med-word.com/?l=CH

Cholestenes | Profiles RNSCholestenes | Profiles RNS

"Cholestenes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cholestenes" by people in this website by year, and whether " ... Below are the most recent publications written about "Cholestenes" by people in Profiles. ...
more infohttps://profiles.rush.edu/display/20516

Ergocalciferols | Profiles RNSErgocalciferols | Profiles RNS

Cholestenes [D04.808.247.222]. *Ergocalciferols [D04.808.247.222.474]. *Sterols [D04.808.247.808]. *Ergocalciferols [D04.808. ...
more infohttps://profiles.rush.edu/display/2965

Hollins UniversityHollins University

Aggregating the worlds patents, patent applications, research grants, technology and inventors allowing universities and companies to showcase and share influential technologies and research.
more infohttps://search.wellspringsoftware.net/organization/hollins-university