Cholesteatoma, Middle Ear: A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.Cholesteatoma: A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Mastoid: The posterior part of the temporal bone. It is a projection of the petrous bone.Ear Ossicles: A mobile chain of three small bones (INCUS; MALLEUS; STAPES) in the TYMPANIC CAVITY between the TYMPANIC MEMBRANE and the oval window on the wall of INNER EAR. Sound waves are converted to vibration by the tympanic membrane then transmitted via these ear ossicles to the inner ear.Tympanoplasty: Surgical reconstruction of the hearing mechanism of the middle ear, with restoration of the drum membrane to protect the round window from sound pressure, and establishment of ossicular continuity between the tympanic membrane and the oval window. (Dorland, 28th ed.)Ear Diseases: Pathological processes of the ear, the hearing, and the equilibrium system of the body.Ear Canal: The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.Tympanic Membrane: An oval semitransparent membrane separating the external EAR CANAL from the tympanic cavity (EAR, MIDDLE). It contains three layers: the skin of the external ear canal; the core of radially and circularly arranged collagen fibers; and the MUCOSA of the middle ear.Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Otoscopy: Examination of the EAR CANAL and eardrum with an OTOSCOPE.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Otitis Media: Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.Otologic Surgical Procedures: Surgery performed on the external, middle, or internal ear.Otitis Media, Suppurative: Inflammation of the middle ear with purulent discharge.Middle Ear Ventilation: Ventilation of the middle ear in the treatment of secretory (serous) OTITIS MEDIA, usually by placement of tubes or grommets which pierce the TYMPANIC MEMBRANE.Ear Neoplasms: Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).Hearing Loss, Conductive: Hearing loss due to interference with the mechanical reception or amplification of sound to the COCHLEA. The interference is in the outer or middle ear involving the EAR CANAL; TYMPANIC MEMBRANE; or EAR OSSICLES.Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Eustachian Tube: A narrow passageway that connects the upper part of the throat to the TYMPANIC CAVITY.Incus: One of three ossicles of the middle ear. It conducts sound vibrations from the MALLEUS to the STAPES.Chinchilla: A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research.Mastoiditis: Inflammation of the honeycomb-like MASTOID BONE in the skull just behind the ear. It is usually a complication of OTITIS MEDIA.Acoustic Impedance Tests: Objective tests of middle ear function based on the difficulty (impedance) or ease (admittance) of sound flow through the middle ear. These include static impedance and dynamic impedance (i.e., tympanometry and impedance tests in conjunction with intra-aural muscle reflex elicitation). This term is used also for various components of impedance and admittance (e.g., compliance, conductance, reactance, resistance, susceptance).Ear, External: The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.Malleus: The largest of the auditory ossicles, and the one attached to the membrana tympani (TYMPANIC MEMBRANE). Its club-shaped head articulates with the INCUS.Petrous Bone: The dense rock-like part of temporal bone that contains the INNER EAR. Petrous bone is located at the base of the skull. Sometimes it is combined with the MASTOID PROCESS and called petromastoid part of temporal bone.Cochlear Diseases: Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).Stapes: One of the three ossicles of the middle ear. It transmits sound vibrations from the INCUS to the internal ear (Ear, Internal see LABYRINTH).Proflavine: Topical antiseptic used mainly in wound dressings.Ossicular Replacement: Surgical insertion of an implant to replace one or more of the ear ossicles.Cerebrospinal Fluid Otorrhea: Discharge of cerebrospinal fluid through the external auditory meatus or through the eustachian tube into the nasopharynx. This is usually associated with CRANIOCEREBRAL TRAUMA (e.g., SKULL FRACTURE involving the TEMPORAL BONE;), NEUROSURGICAL PROCEDURES; or other conditions, but may rarely occur spontaneously. (From Am J Otol 1995 Nov;16(6):765-71)Second-Look Surgery: A followup operation to examine the outcome of the previous surgery and other treatments, such as chemotherapy or radiation therapy.Ossicular Prosthesis: An implant used to replace one or more of the ear ossicles. They are usually made of plastic, Gelfoam, ceramic, or stainless steel.Stapedius: A tiny muscle that arises from the posterior wall of the TYMPANIC CAVITY of MIDDLE EAR with its tendon inserted onto the neck of the STAPES. Stapedius pulls the stapes posteriorly and controls its movement.Audiometry, Pure-Tone: Measurement of hearing based on the use of pure tones of various frequencies and intensities as auditory stimuli.Cranial Fossa, Middle: The compartment containing the anterior extremities and half the inferior surface of the temporal lobes (TEMPORAL LOBE) of the cerebral hemispheres. Lying posterior and inferior to the anterior cranial fossa (CRANIAL FOSSA, ANTERIOR), it is formed by part of the TEMPORAL BONE and SPHENOID BONE. It is separated from the posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) by crests formed by the superior borders of the petrous parts of the temporal bones.Audiometry: The testing of the acuity of the sense of hearing to determine the thresholds of the lowest intensity levels at which an individual can hear a set of tones. The frequencies between 125 and 8000 Hz are used to test air conduction thresholds and the frequencies between 250 and 4000 Hz are used to test bone conduction thresholds.Echo-Planar Imaging: A type of MAGNETIC RESONANCE IMAGING that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.Round Window, Ear: Fenestra of the cochlea, an opening in the basal wall between the MIDDLE EAR and the INNER EAR, leading to the cochlea. It is closed by a secondary tympanic membrane.Tensor Tympani: A short muscle that arises from the pharyngotympanic tube (EUSTACHIAN TUBE) and inserts into the handle of the MALLEUS. This muscle pulls the handle medially thus controlling the tension and movement of TYMPANIC MEMBRANE.Hearing: The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition.Bone Conduction: Transmission of sound waves through vibration of bones in the SKULL to the inner ear (COCHLEA). By using bone conduction stimulation and by bypassing any OUTER EAR or MIDDLE EAR abnormalities, hearing thresholds of the cochlea can be determined. Bone conduction hearing differs from normal hearing which is based on air conduction stimulation via the EAR CANAL and the TYMPANIC MEMBRANE.Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Semicircular Canals: Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS.Fistula: Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.Diffusion Magnetic Resonance Imaging: A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.Optical Imaging: The use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS.Skull Neoplasms: Neoplasms of the bony part of the skull.HSP27 Heat-Shock Proteins: A subfamily of small heat-shock proteins that function as molecular chaperones that aid in refolding of non-native proteins. They play a protective role that increases cellular survival during times of stress.Microsurgery: The performance of surgical procedures with the aid of a microscope.Otolaryngology: A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Law Enforcement: Organized efforts to insure obedience to the laws of a community.Environment Design: The structuring of the environment to permit or promote specific patterns of behavior.Chronology as Topic: The temporal sequence of events that have occurred.Cranial Sinuses: Large endothelium-lined venous channels situated between the two layers of DURA MATER, the endosteal and the meningeal layers. They are devoid of valves and are parts of the venous system of dura mater. Major cranial sinuses include a postero-superior group (such as superior sagittal, inferior sagittal, straight, transverse, and occipital) and an antero-inferior group (such as cavernous, petrosal, and basilar plexus).Sinus Thrombosis, Intracranial: Formation or presence of a blood clot (THROMBUS) in the CRANIAL SINUSES, large endothelium-lined venous channels situated within the SKULL. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe HEADACHE; SEIZURE; and other neurological defects.Dura Mater: The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.Cerebral Veins: Veins draining the cerebrum.Arachnoid: A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.Poly A: A group of adenine ribonucleotides in which the phosphate residues of each adenine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Fagopyrum: A plant genus of the family POLYGONACEAE that is used as an EDIBLE GRAIN. Although the seeds are used as cereal, the plant is not one of the cereal grasses (POACEAE).Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Fasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Fascia: Layers of connective tissue of variable thickness. The superficial fascia is found immediately below the skin; the deep fascia invests MUSCLES, nerves, and other organs.Eosinophilia: Abnormal increase of EOSINOPHILS in the blood, tissues or organs.Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.Fasciitis, Plantar: Inflammation of the thick tissue on the bottom of the foot (plantar fascia) causing HEEL pain. The plantar fascia (also called plantar aponeurosis) are bands of fibrous tissue extending from the calcaneal tuberosity to the TOES. The etiology of plantar fasciitis remains controversial but is likely to involve a biomechanical imbalance. Though often presenting along with HEEL SPUR, they do not appear to be causally related.Neurotology: A subspecialty of otolaryngology dealing with the parts of the nervous system related to the ear.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.HLA-B15 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.Conjunctival DiseasesCarbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Receptor-Like Protein Tyrosine Phosphatases, Class 8: A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesion recognition motif and a single cytosolic protein tyrosine phosphate domain.Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.Protein Tyrosine Phosphatases: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Protein Tyrosine Phosphatase, Non-Receptor Type 1: A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.Otorhinolaryngologic Surgical Procedures: Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.Cleft Lip: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.World War I: Global conflict primarily fought on European continent, that occurred between 1914 and 1918.Famous PersonsVermontNew HampshireOtosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.Vertigo: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)Paranasal Sinuses: Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.Sinusitis: Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.

Differentiation characteristics of cholesteatoma epithelium determined by expression of transglutaminase isoenzymes. (1/94)

Transglutaminase (TGase) isoenzymes are involved in the process of the differentiation and cornification of keratinocytes in the epidermis. This study investigates the presence and localization of three TGase isoenzymes to elucidate the nature and differentiation status of the squamous epithelium in human aural cholesteatoma. Twenty cholesteatoma specimens were used. The presence and localization of three TGase isoenzymes were studied by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. mRNA expression of three TGase isoenzymes were detected in the tested cholesteatomas with variable levels. The immunohistochemical staining patterns of three TGase isoenzymes showed variations within specimens, relating to keratinizing activity. TGase K is the most abundant among three isoenzymes. Keratinizing epithelium of cholesteatoma have similar expression profiles of TGase isoenzymes with those of epidermis of the skin. Other areas, particularly those showing non-keratinizing epithelium, showed weak immunostaining of TGase E and C, suggesting its different maturation status from keratinizing epithelium. The results of this study indicate that epithelium of cholesteatoma undergoes same direction of maturation and differentiation characteristics as the epidermis of skin, evidenced by similar expressions of TGases both in mRNA level and immunohistochemistry.  (+info)

Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma. (2/94)

Cholesteatoma is a nonneoplastic lesion of the middle ear space or mastoid that is histologically characterized by a progressive bone erosion of the ossicles and surrounding bone. Several matrix-degrading enzymes have been implicated as mediators of this bone erosion. Because the novel cysteine proteinase cathepsin K has been shown to play a central role in bone resorption, we examined the expression of this enzyme in tissue specimens of cholesteatoma. Tissue specimens of 9 patients with cholesteatoma were obtained during middle-ear surgery. Expression of cathepsin K mRNA was determined by RT-PCR using specific primers. Immunohistochemical analysis of cathepsin K protein expression in tissue sections was performed by using the streptavidin-alkaline phosphatase technique. Expression of both cathepsin K mRNA and protein was detected in areas affected by cholesteatoma, whereas specimens of nonaffected ear cartilage and surrounding tissue were not positive. In addition, cathepsin K was detected in numerous multinucleated giant cells, particularly osteoclasts at the site of bone degradation. In contrast, keratinized squamous epithelium was negative for cathepsin K. These data demonstrate that the matrix-degrading cysteine proteinase cathepsin K may be involved in bone erosion in cholesteatoma. Strong expression of this collagenolytic enzyme in osteoclasts suggests that these cells are mainly involved in cathepsin K-mediated bone destruction.  (+info)

Diffusion-weighted imaging for differentiating recurrent cholesteatoma from granulation tissue after mastoidectomy: case report. (3/94)

Identification of recurrent cholesteatoma and differentiation from postoperative granulation tissue is important in a patient who has undergone mastoidectomy for cholesteatoma. We describe the diffusion-weighted imaging findings and apparent diffusion coefficient values in a case of recurrent cholesteatoma. This case suggests possible differentiation of cholesteatoma from granulation tissue on the basis of diffusion-weighted imaging findings.  (+info)

Immunohistochemical investigations of cathepsin D activity in the structures of cholesteatoma. (4/94)

BACKGROUND: Cathepsin D decomposes cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. It takes part in angiogenesis and activates osteoclasts, and is thought to play a major role in the destruction of bone tissue by cholesteatoma. The aim of the present study was to evaluate the activity of cathepsin D in the structures of cholesteatoma. MATERIAL/METHODS: Cholesteatomas were collected from 16 patients operated on for chronic inflammation of the middle ear. Specimens were fixed in formalin at pH 7.2, after which parrafin slices were made. Cathepsin D was assayed with a Dako set. Keratin was measured by the Kreyberg method. Normal skin from behind the ear was taken from the patients during the same operation. The samples included a stratified, desquamative epithelium (matrix), a streak containing connective tissue (perimatrix), and a mass of keratin debris. RESULTS: Cathepsin D demonstrates high activity in perimatrix cells adjacent to bone tissue, while it occurs in trace amounts in the matrix. A highly positive reaction was observed within keratin, which was present in the superficial layer of the epithelium. Pseudocathepsin located in desquamative epithelial cells demonstrated a high positive reaction. There were trace amounts of cathepsin D within the dermis. In the control group (the skin samples), there were trace amounts of cathepsin D within the corneous layer of the epithelium. CONCLUSIONS: Cathepsin D places a major role in bone tissue destruction due to cholesteatoma.  (+info)

Expression patterns of cytokeratins in cholesteatomas: evidence of increased migration and proliferation. (5/94)

Aural cholesteatoma is characterized by invading squamous epithelia with altered growth properties. Cytokeratin (CK) expression is affected in epidermal proliferative diseases and represents the alterations of keratinocyte proliferation, differentiation, and migration. In the present study, the intensity of CK immuno-expression was determined, using densitometry at various sites in experimental cholesteatoma in order to characterize changes of keratinocytes. With cholesteatoma formation, CK4, a marker for non-keratinizing epithelia, increased in the suprabasal layers of the annular external auditory canal (EAC) and at the pars tensa indicating an altered differentiation and migration of keratinocytes. CK5/6, a marker of keratinizing squamous epithelium, increased only at the pars tensa of the tympanic membrane, indicating basal keratinocyte hyperplasia. CK1/10 increased in the suprabasal layer at the annular EAC, and at the peripheral pars tensa, indicating increased terminal differentiation of keratinocytes. CK13/16, markers of differentiation and hyperproliferation, increased in suprabasal layer of the EAC, and at the peripheral pars tensa. However, it decreased in the basal layer of the EAC, indicating hyperproliferation and migration of keratinocytes. The findings of this study support the basal cell hyperplasia hypotheses for the pathogenesis of aural cholesteatoma, with regard to hyperproliferation, migration, and an altered differentiation of keratinocytes.  (+info)

External auditory canal cholesteatoma: clinical and imaging spectrum. (6/94)

BACKGROUND AND PURPOSE: Cholesteatoma is an inflammatory lesion of the temporal bone that uncommonly involves the external auditory canal (EAC). In this large case series, we aimed to define its imaging features and to determine the characteristics most important to its clinical management. METHODS: Thirteen cases of EAC cholesteatoma (EACC) were retrospectively reviewed. Clinical data were reviewed for the history, presentation, and physical examination findings. High-resolution temporal bone CT scans were examined for a soft-tissue mass in the EAC, erosion of adjacent bone, and bone fragments in the mass. The middle ear cavity, mastoid, facial nerve canal, and tegmen tympani were evaluated for involvement. RESULTS: Patients presented with otorrhea, otalgia, or hearing loss. Eight cases were spontaneous, and five were postsurgical or post-traumatic. CT imaging in all 13 cases showed a soft-tissue mass with adjacent bone erosion. Intramural bone fragments were identified in seven cases. This mass most often arose inferiorly (n = 8) or posteriorly (n = 8), but it was circumferential in two cases. We noted middle ear extension (n = 5), mastoid involvement (n = 4), facial canal erosion (n = 2), and tegmen tympani dehiscence (n = 1). CONCLUSION: Temporal bone CT shows EACC as a soft-tissue mass within the EAC, with adjacent bone erosion. Bone fragments may be present within the mass. The cholesteatoma may extend into the mastoid or middle ear, or it may involve the facial nerve canal or tegmen tympani. Recognition of this entity and its possible extension is important because it may influence clinical management.  (+info)

Differential diagnosis and treatment of hearing loss. (7/94)

Hearing loss is a common problem that can occur at any age and makes verbal communication difficult. The ear is divided anatomically into three sections (external, middle, and inner), and pathology contributing to hearing loss may strike one or more sections. Hearing loss can be categorized as conductive, sensorineural, or both. Leading causes of conductive hearing loss include cerumen impaction, otitis media, and otosclerosis. Leading causes of sensorineural hearing loss include inherited disorders, noise exposure, and presbycusis. An understanding of the indications for medical management, surgical treatment, and amplification can help the family physician provide more effective care for these patients.  (+info)

Closed tympanoplasty in middle ear cholesteatoma surgery. (8/94)

OBJECTIVE: To determine the effect of closed tympanoplasty surgery for middle ear cholesteatoma and to compare the postoperative results with the outcomes of canal-wall-down mastoidectomy. METHODS: Seventy patients with middle ear cholesteatoma were involved in the study. Pneumo-otoscopy, pure-tone audiometry, anamnestic and clinical data were evaluated before the surgery. Modified radical mastoidectomy was performed for 31 patients. Thirty-nine patients were treated with closed tympanoplasty surgery, including intact canal wall mastoidectomy, endaural atticotomy, lateral attic and aditus wall reconstruction and tympanoplasty. The follow-up examination was carried out 12 months after the surgery. The recurrence of cholesteatoma, otorrhea and hearing level were evaluated postoperatively. RESULTS: Otorrhea was estimated in 4 cases (10.3%) after closed tympanoplasty surgery and in 6 cases (19.4%) after modified radical mastoidectomy. Among the patients who were operated using closed tympanoplasty technique the middle ear cholesteatoma recurrence rate was 12.8% and among those, who underwent modified radical mastoidectomy recurrent disease occurred in 9.7% of the cases. The hearing improvement was found in 15 cases (38.46%) after closed tympanoplasty, while there was no hearing improvement after modified radical mastoidectomy. CONCLUSIONS: We conclude that despite the fact, that cholesteatoma recurrence rate after closed tympanoplasty is relatively high, this surgical method permits to preserve adequate hearing level and releases from postoperative cavity care problems as compared with modified radical mastoidectomy.  (+info)

*Koerner's septum

Along with the middle ear ossicles, it is usually eroded in middle ear cholesteatomas. Superiorly, this continues as the ... Gaurano, JL; Joharjy, IA (2004). "Middle ear cholesteatoma: characteristic CT findings in 64 patients". Annals of Saudi ...

*ICAM2

"Expression of human intercellular adhesion molecules in middle ear cholesteatoma". American Journal of Otolaryngology. 15 (4): ...

*Conductive hearing loss

Cholesteatoma Otosclerosis, abnormal growth of bone in or near the middle ear middle ear tumour ossicular discontinuity as a ... Some conditions are amenable to surgical intervention such as middle ear fluid, cholesteatoma, otosclerosis. If conductive ... Blocking of the eustachian tube leads to decreased pressure in the middle ear relative to the external ear, and this causes ... infection or irritation of the outer ear Exostoses, abnormal growth of bone within the ear canal Tumor of the ear canal ...

*List of MeSH codes (C17)

... cholesteatoma MeSH C17.800.428.260.300 --- cholesteatoma, middle ear MeSH C17.800.428.333 --- ichthyosis MeSH C17.800.428.333. ...

*Prussak's space

This cholesteatoma, in turn, can erode the middle ear ossicles, facial nerve, inner ear and even involve the brain. From ... In human anatomy, Prussak's Space is the small middle ear recess, bordered laterally by the flaccid part of Shrapnell's ... A cholesteatoma forms when there is a deep retraction pocket in the tympanic membrane. The lining of the tympanic membrane, ... The debris collects and enlarges and ultimately forms a cholesteatoma. ...

*Cholesteatoma

... may also arise as a result of metaplasia of the middle ear mucosa or implantation following trauma. Cholesteatoma ... Congenital cholesteatomas are usually middle ear epidermal cysts that are identified deep within an intact ear drum. Keratin- ... Not all middle ear epidermal cysts are congenital, as they can be acquired either by metaplasia of the middle ear mucosa or by ... perforation or ear surgery Congenital cholesteatomas occur at three important sites: the middle ear, the Petrous apex, and the ...

*ICD-10 Chapter VIII: Diseases of the ear and mastoid process

Cholesteatoma of middle ear (H72) Perforation of tympanic membrane (H73) Other disorders of tympanic membrane (H74) Other ... disorders of middle ear and mastoid (H75) Other disorders of middle ear and mastoid in diseases classified elsewhere (H80) ... Other specified disorders of ear (H93.9) Disorder of ear, unspecified (H94) Other disorders of ear in diseases classified ... H60) Otitis externa (H60.4) Keratosis obturans (H61) Other disorders of external ear (H62) Disorders of external ear in ...

*Otitis media

When a cholesteatoma or granulation tissue is present in the middle ear, the degree of hearing loss and ossicular destruction ... the negative middle-ear pressure can reach a point where fluid from the surrounding tissues is sucked into the middle ear's ... middle ear) oedema, ulceration and perforation. The middle ear attempts to resolve this ulceration by production of granulation ... is a chronic inflammation of the middle ear and mastoid cavity that is characterised by discharge from the middle ear through a ...

*Ear

"Evaluation and management of middle ear trauma". www.uptodate.com. Retrieved 2016-02-25. "Cholesteatoma: MedlinePlus Medical ... The human ear consists of three parts-the outer ear, middle ear and inner ear. The ear canal of the outer ear is separated from ... In mammals, the ear is usually described as having three parts-the outer ear, middle ear and the inner ear. The outer ear ... During embryogenesis the ear develops as three distinct structures: the inner ear, the middle ear and the outer ear. Each ...

*Jacob Sadé

... cholesteatoma, the facial nerve, equilibrium, and microsurgery of the middle ear. He was the first in Israel to introduce a ... These findings led to further studies related to middle ear pressure vacillation and problems of middle ear aeration and gas ... Middle Ear Pressure and Mastoid Pneumatization Index". Acta Oto-Laryngol, 116:284-287 Sadé, J., Ar Amos (1997), "The Middle Ear ... Sadé, J., Luntz M. (1988), "Fluctuations of Middle Ear Aeration in Atelectatic Ears". Acta Oto-Laryngol (Stockh) Suppl, 458:48- ...

*Glossary of communication disorders

Cholesteatoma Accumulation of dead cells in the middle ear, caused by repeated middle ear infections. Cochlea Snail-shaped ... Middle ear Part of the ear that includes the eardrum and three tiny bones of the middle ear, ending at the round window that ... Perilymph fistula Leakage of inner ear fluid to the middle ear that occurs without apparent cause or that is associated with ... Round window Membrane separating the middle ear and inner ear. Sensorineural hearing loss Hearing loss caused by damage to the ...

*Mastoidectomy

In addition, it is sometimes performed as part of other procedures (cochlear implant) or for access to the middle ear. There ... because to not to give the chance for the infection or the cholesteatoma for that matter to spread into the middle cranial ... In Radical and Modified Mastoidectomy the mastoid and middle ear cavities are exteriorized, ... Removal of Mastoid air cells is undertaken without affecting the middle ear. This is typically done for mastoiditis Modified ...

*Mastoiditis

Some mastoiditis is caused by cholesteatoma, which is a sac of keratinizing squamous epithelium in the middle ear that usually ... results from repeated middle-ear infections. If left untreated, the cholesteatoma can erode into the mastoid process, producing ... These serve to drain the pus from the middle ear, helping to treat the infection. The tube is extruded spontaneously after a ... Mastoiditis is usually caused by untreated acute otitis media (middle ear infection) and used to be a leading cause of child ...

*Facial nerve paralysis

Inflammation from the middle ear can spread to the canalis facialis of the temporal bone - through this canal travels the ... A chronically discharging ear must be treated as a cholesteatoma until proven otherwise; hence, there must be immediate ... Otitis media is an infection in the middle ear, which can spread to the facial nerve and inflame it, causing compression of the ... Chronic otitis media usually presents in an ear with chronic discharge (otorrhea), or hearing loss, with or without ear pain ( ...

*Tympanosclerosis

... which refers to any other location within the middle ear such as the ossicular chain, middle ear mucosa or, less frequently, ... Cholesteatoma is similar in appearance but the whiteness is behind the tympanic membrane, rather than inside.[citation needed] ... Computerised tomography (CT) can be used to determine if disease is present in the middle ear. Whilst hearing loss is a common ... Tympanosclerosis, on the other hand, can cause significant hearing loss or chalky, white patches on the middle ear or tympanic ...

*Tympanic membrane retraction

... maneuver increases middle ear pressure and can push a retracted eardrum out of the middle ear if is not adherent to middle ear ... When keratin becomes trapped deep inside the ear and cannot be cleaned out, it is known as cholesteatoma. Growth of bacteria in ... When gas pressure within the middle ear is less than atmospheric pressure, the eardrum can become sucked into the middle ear ... This can result in erosion of bone and accumulation of dead skin (keratin) within the ear. As the middle ear is only a narrow ...

*Otic polyp

... in response to a longstanding inflammatory process of the middle ear. Patients usually present with otorrhea, conductive ... such as a concurrent cholesteatoma. By gross description, there is usually a solitary, polypoid, reddish mass behind an intact ... ear drum (typmanic membrane). The tissue is often friable, measuring ...

*Eardrum

Middle ear Valsalva maneuver to equalize pressure across the eardrum External and middle ear, opened from the front (right side ... Collapse or retraction of the eardrum can cause conductive hearing loss or cholesteatoma. The oblique placement of the tympanic ... or to drain pus from the middle ear. The fluid or pus comes from a middle ear infection (otitis media), which is a common ... cone-shaped membrane that separates the external ear from the middle ear. Its function is to transmit sound from the air to the ...

*Ear canal

... by the wearing away of skin in the canal Cholesteatoma Contact dermatitis of the ear canal Ear fungus Ear mites in animals Ear ... is a tube running from the outer ear to the middle ear. The adult human ear canal extends from the pinna to the eardrum and is ... External and middle ear, opened from the front. Right side. Horizontal section through left ear; upper half of section. Lateral ... "Structural and functional anatomy of the outer and middle ear". In W. Clark & K. Ohlemiller (Eds.), Anatomy and physiology of ...

*Labyrinthine fistula

... an abnormal connection between the fluid of the inner ear and the air-filled middle ear. This connection is caused by a rupture ... Finally, disease conditions-for example cholesteatoma-can result in a labyrinthine fistula. Traumatic events, with excessive ... resulting in leakage of the perilymph from the Cochlea into the middle ear. This includes specifically a perilymph fistula (PLF ... of the round window that separate the inner and middle ear. Another type of l.f. is a semicircular canal dehiscence, which ...

*Neurotology

Many general otolaryngologists are trained in otology or middle ear surgery, performing surgery such as a tympanoplasty, or a ... such as removal of complex cholesteatoma, labyrinthectomy, surgery of the endolymphatic sac for meniere's disease and cochlear ... Otology generally refers to the treatment of middle ear disease and resultant conductive hearing loss, whereas neurotology ... Neurotology or neuro-otology is a branch of clinical medicine which studies and treats neurological disorders of the ear. It is ...

*Temporal bone

... formed from the fusion of a number of bones surrounding the ear of reptiles. The delicate structure of the middle ear, unique ... Chorda tympani Cholesteatoma Koerner's septum Temporal muscle Temporomandibular joint This article incorporates text in the ... A glomus jugulare tumor is a tumor of the part of the temporal bone in the skull that involves the middle and inner ear ... and longitudinal with injuries to the middle ear ossicles. More recently, delineation based on disruption of the otic capsule ...

*Myringotomy

... or to drain pus from the middle ear. A tympanostomy tube is inserted into the eardrum to keep the middle ear aerated for a ... cholesteatoma, or thinning or persistent perforation of the tympanic membrane.[citation needed] Evidence suggests that ... If middle ear disease has been severe or prolonged enough to justify tube placement, there is a strong possibility that the ... This perforation remains patent for several weeks and provides ventilation of the middle ear without the need for tube ...

*Tympanostomy tube

When it is necessary to keep the middle ear ventilated for a very long period, a "T"-shaped tube may be used, as these "T-tubes ... cholesteatoma, tympanosclerosis and others, as opposed to tubes designed to last for shorter durations. A common complication ... Chronic otitis media with persistent effusion for six months (one ear) or three months (both ears).[citation needed] Persistent ... is a small tube inserted into the eardrum in order to keep the middle ear aerated for a prolonged period of time, and to ...

*Ádám Politzer

... to treat internal ear diseases by insufflating the middle ear through the Eustachian tube, which obviated the need of its ... He also studied the pathology of cholesteatoma, serous otitis media, labyrinthitis, congenital deafness and intracranial ... such as an ear perforator, a surgical knife, a grommet for the ventilation of the inner ear after paracentesis, as well as a ... Politzer was a prolific inventor of new medical devices for the diagnosis and treatment of ear diseases. He developed several ...

*Facial nerve decompression

... enables visualization of the entire course of the facial nerve and still preserves function of the inner ear. The middle ... Other tumours which can compress facial nerve along its course like congenital cholesteatomas, hemangiomas, acoustic neuromas, ... The middle cranial fossa route is the only method that can be use to expose the entire I.A.C. and labyrinthine segment with ... This middle cranial fossae exposure is used to expose I.A.C. and labyrinthine segment of the facial nerve when hearing ...
Abstract Conclusion: The detection of the HER4 receptor in 50% of cholesteatomas but never in the reference tissue, and the increased expression of its activating ligand EPI, suggest that EPI-mediated activation of HER4 might play a role in cholesteatoma growth. Objective: To investigate the expression of the epidermal growth factor (EGF) system in human middle ear cholesteatoma. Methods: Forty-seven patients referred for surgery due to cholesteatoma were included in the study. Clinical data were collected. Biopsies of cholesteatoma and skin from the external ear canal were obtained during surgery. mRNA expression was quantified with real-time PCR. The corresponding proteins were visualized using immunohistochemistry. Results: A systematic investigation of all four receptors, HER1, HER2, HER3, and HER4, and the ligands EGF, transforming growth factor (TGF)-α, amphiregulin (AR), heparin-binding EGF-like growth factor (HB-EGF), and epiregulin (EPI) of the EGF system is presented. At the mRNA ...
Although middle-ear cholesteatoma is a major topic in otological research, its etiology and pathogenesis remain unclear. Pediatric cholesteatoma is considered more aggressive than adult cholesteatoma, as it has a higher rate of growth, is more often infected and exhibits wider extension. Higher incidence of residual and recurrent disease after surgical treatment of pediatric cholesteatoma has been observed in most studies. In this study, the results are presented from a canal wall down (CWD) obliteration technique used in 330 adult patients (Paper I) with cholesteatoma, evaluated at 1, 3 and 6 years following surgery. Additionally, results are offered from 57 pediatric patients (Paper II) using identical surgical technique and compared with adults. The surgical and hearing outcomes in both groups showed a low incidence of residual and recurrent disease and a high rate of ear water resistance without infection. The results were unrelated to the severity and extension of disease, as well as to age ...
Cholesteatoma surgery What is cholesteatoma surgery? This surgery aims to remove cholesteatoma and stop the discharge. It may be possible to improve your hearing at the same time. What is a cholest...
Cholesteatoma is a destructive and expanding growth of keratinizing squamous epithelium in the middle ear or petrous apex. The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. In this study, comparative proteomic analysis was conducted to investigate the roles of specific proteins in the pathways regarding keratinocyte proliferation in cholesteatoma. The differential proteins were detected by comparing the two-dimension electrophoresis (2-DE) maps of the epithelial tissues of 12 attic cholesteatomas with those of retroauricular skins. There were 14 upregulated proteins in the epithelial tissues of cholesteatoma in comparison with retroauricular skin. The modulation of five crucial proteins, HSP27, PRDX2, GRP75, GRP78 and GRP94, was further determined by RT-PCR, Western blot and immunohistochemistry. Phosphorylation of HSP27 at Ser-82 was identified by mass spectroscopy. The results of this study suggested that phosphorylated HSP27
Cholesteatoma is a destructive and expanding growth of keratinizing squamous epithelium in the middle ear or petrous apex. The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. In this study, comparative proteomic analysis was conducted to investigate the roles of specific proteins in the pathways regarding keratinocyte proliferation in cholesteatoma. The differential proteins were detected by comparing the two-dimension electrophoresis (2-DE) maps of the epithelial tissues of 12 attic cholesteatomas with those of retroauricular skins. There were 14 upregulated proteins in the epithelial tissues of cholesteatoma in comparison with retroauricular skin. The modulation of five crucial proteins, HSP27, PRDX2, GRP75, GRP78 and GRP94, was further determined by RT-PCR, Western blot and immunohistochemistry. Phosphorylation of HSP27 at Ser-82 was identified by mass spectroscopy. The results of this study suggested that phosphorylated HSP27
Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and/or mastoid process. Although cholesteatomas are not classified as either tumors or cancers, they can still cause significant problems because of their erosive and expansile properties resulting in the destruction of the bones of the middle ear (ossicles), as well as their possible spread through the base of the skull into the brain. They are also often infected and can result in chronically draining ears. The majority (98%) of patients with cholesteatoma have ear discharge or hearing loss or both in the affected ear. Other more common conditions, such as otitis externa, may also present with these symptoms, but cholesteatoma is much more serious and should not be overlooked. If a patient presents to a doctor with ear discharge and hearing loss, the doctor should consider the patient to have cholesteatoma until the disease is definitely excluded. Other less common symptoms (all ...
1. Sudhoff, H., Bujia, J., Holly, A., Kim, C., Fisseler-Eckhoff, A. Functional characterization of middle ear mucosa residues in cholesteatoma samples. American Journal of Otology 15, 217 - 221, 1994. 2. Fisseler-Eckhoff, A., Becker, T., Sudhoff, H., Müller, K.-M. AgNOR counts in preneoplastic lesions of the bronchus. Pathology Research and Practice 190, 389 - 393, 1994. 3. Bujia, J., Kremer, D., Sudhoff, H., Viviente, E., Sprekelsen, C., Wilmes, E. Determination of viability of cryoconserved cartilage grafts. European Archives of Oto-Rhino-Laryngology 252, 30-34, 1995. 4. Sudhoff, H., Bujia, , Fisseler-Eckhoff, A., Schulz-Flake, C., Hildmann, H. Expression of the cell-cycle- related antigen (MIB 1) in cholesteatoma and auditory meatal skin. Laryngoscope 105, 1227-1231, 1995. 5. Bujia, J., Holly A., Sudhoff, H., Antoli-Candela, F., Guzman Tapia, M., Kastenbauer, E. Identification of proliferating keratinocytes in middle ear cholesteatoma using the monoclonal antibody Ki-67. ORL 58, 23- 26, ...
Cholesteatomas actively erode bone because they contain enzymes which are activated by moisture. In time, cholesteatomas will eventually erode the bone leading into the inner ear. This can cause nerve loss and deafness as well as severe imbalance and dizziness. The thin plate of bone that separates the roof of the ear from the brain can also be eroded by cholesteatomas. This exposes the covering of the brain. In extreme situations, it can lead to brain infection and other severe complications. For the possible origins of cholesteatomas, please click here.. Cholesteatoma is a serious condition and, when diagnosed, requires prompt treatment. Medical treatment concentrates on drying the infection within the ear. Antibiotics, given both by mouth and drops in the ear, combined with weekly cleaning of the ear under the surgical microscope, can clear up the infection.. Polyps (growth of inflamed tissue) are often present in the ear with cholesteatoma.. The polyps can shrink or may have to be surgically ...
Hearing preservation is, of course, a major concern but should not take precedence over removing the invasive tumor. Most patients who undergo surgery for cholesteatoma are able to maintain or improve their hearing at a subsequent operation for reconstruction of the bones of hearing. However, individuals may not be candidates for further reconstructive surgery if irreversible changes took place in the ear due to the disease. A hearing aid fitting will usually be considered in this situation.. In some instances (less than 1% of operations for cholesteatomas), complete hearing can be lost at the time of surgery or during the healing process. This loss may be due to erosion of the window connecting the middle ear to the inner ear via the invasion of the cholesteatoma, or infection passing through this defect.. The ear drum is generally repaired at the time of surgery by inserting a grafted, new ear drum taken from tissue behind the ear over the skull. In most cases, this new grafted ear drum heals. ...
Cholesteatoma of a salivary gland. Light micrograph of a section through a cholesteatoma in the parotid gland. Cholesteatomas are destructive expanding growths consisting of keratinised squamous epithelium. They are not tumours or cancers but can cause significant problems because of the damage they can cause through erosion of and expanding into existing tissues. - Stock Image C023/5534
In the words of Dr. Mark Levenson, Cholesteatoma is a serious condition and, when diagnosed, requires prompt treatment. What is cholesteatoma? How can it be treated? Who are likely victims? What are the effects? I chose to find out. Cholesteatoma was...
In less extensive cholesteatomas, especially when infection is well controlled before surgery, an intact canal wall operation may be the favoured procedure. This operation preserves the wall between the middle ear and mastoid. The principal advantages of the intact canal wall operation are a more normal canal and ear drum, and a greater possibility of hearing restoration. In addition, most patients with the intact canal wall operation can allow water in the ear. The chief disadvantage of the intact canal wall operation is that a regrowth of cholesteatoma may not be evident. Thus, many ear surgeons will delay rebuilding the bones of hearing for a year after an intact canal wall operation for cholesteatoma. The ear drum is opened at the second operation and the bones of hearing are then reconstructed. If a regrowth of cholesteatoma is found, the disease is again removed and reconstruction may be delayed for another 6 months or a year. Repeat CT scans may also be performed in some cases to avoid ...
(504) 889-5335 | Cholesteatoma is an abnormal skin growth in the middle ear behind the eardrum that may also affect the mastoid (skull bone). It begins as a cyst that
Attic fans were originally installed with the primary purpose to exhaust the hot, humid air from attics and attic crawlspaces. Attic ventilation fans do much more than that. The attic ventilation fan creates a negative pressure in the attic or attic crawlspace, which causes the hot air to flow up into the attic from ...
First, thank you for taking the time to read my question of concern. I only need to know if ear drops can contribute to the growing of a cholesteatoma? I am not sure if I can mention the name, ciprod...
your doctor will look inside your ear with an otoscope -- an instrument that has a magnifying glass and a light on it. shell also test how well you can hear sounds to see if your cholesteatoma has af
Diffusion MRI (non-EPI DWI or TSE DWI) allows to identify with high accuracy the presence of a cholesteatoma (acquired or recurrent).
Learn more about Cholesteatoma at St. Petersburg General Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Cholesteatoma at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Cholesteatoma at Grand Strand Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Cholesteatomas are benign tumors in cases where a perforation of the eardrum (tympanic membrane) does not heal without surgery,but instead grows through the hole into the middle ear and, if infectiondevelops, results in a cyst-like tumor.
Ventilation is:. Attic ventilation is the flow of outside air through the space at the underside of the deck of an asphalt shingle roof system.. The benefits of ventilation are:. Ventilation moves heat and moisture out of an attic space. Ventilation helps to prevent premature shingle deterioration and roofing system failure by keeping the attic temperature closer to the outside temperature. Ventilation may also help reduce the risk of moisture-related problems by removing moisture-laden air that may collect in the attic space caused by day-to-day activities in the living space. Ventilation also helps to reduce the risk of ice damming.. Ventilation is achieved by:. Natural attic ventilation is effective because hot air rises. Outside air flows through an attic space when vent openings allow this hot air to rise out of the attic space at the top (exhaust) while cooler air is drawn in at the bottom (intake). To achieve the benefits noted above, there must be sufficient air flow. Ventilation systems ...
In addition to proper insulation in your attic, there are other improvements you can make. Adding an attic fan can increase ventilation and provide benefits all year long, not just in the summer. While a whole house fan can help to provide ventilation throughout the home, an attic fan may be more appropriate for your situation. Ask your contractor if you arent sure.. Call the Hayden ventilation experts at ACI Northwest for more information about how to help weatherize your home for year round comfort and efficiency. To get you started, we have included some of the main ways that attic fans can improve overall home efficiency and prevent moisture problems in the home.. Creating more fresh air circulation in your attic not only helps cool the home in the summer, but it can also prevent moisture related damages. In a home that is already well-insulated and has plenty of ventilation, an attic fan will help with overall efficiency by helping to remove the hot air from the attic. In addition to ...
Cholesteatomas are benign tumors in cases where a perforation of the eardrum (tympanic membrane) does not heal without surgery,but instead grows through.
Best Insulation For Attic.Attic Insulation Companies Calgary Edmonton IDEAL. Attic Insulation And Ceiling Insulation Using Cellulose . How Dirty Attics Affect Indoor Air Quality Brower. Chairs Gallery
Diagnosis Code H71.02 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Choleasteatoma is known as an abnormal squamous epithelial growth in the middle ear. It can erode the bony structures within the temporal bone. This patology o...
Principal Investigator:NAKANO Yuichi, Project Period (FY):1990 - 1992, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Otorhinolaryngology
Reciente formación la de estos alemanes de Attic aunque en ningún caso quiere decir que recién hayan entrado en las huestes del metal más oscuro, en donde varios de sus integrantes ya han tenido la oportunidad de aportillar la escena desde bandas tales como Erazor (black thrash), Iron Kobra (heavy metal) o Warhammer (thrash), por lo que el verles en esta nueva aventura hace pensar que esta gente llevaba mucho tiempo ya craneando la idea de Attic, que básicamente es puro heavy metal de corte oscuro y satanista (en lo lírico) con muchos aires al heavy metal ochentero europeo, no tan pegado eso sí en la NWOBHM, como si en lo hecho por el gran maestro de las sombras, mr. King Diamond, a quien mucho se asemeja tanto en estilo como en performance el frontman de estos germanos como lo es Meister Cagliostro, consiguiendo emular en forma bastante efectiva los típicos falsetes y agudos del danés, con esos cambios de registro que solo a este hombrón pensábamos posible. Después de todo siempre ...
Ducting, Air Circulation and Ventilation Systems - Unique attic ventilation problem - I have a Mansard Victorian style roof which is presenting a problem for ventilating the attic. The first problem
Attic Light - Add some creepy lighting to your Halloween scene when you decorate with the Attic Light. This spooky light comes with an AC adapter, so all you have t
Your how to insulate attic may incorporate price that is authentic to your home if you add the interior square saving form and modernize the backyard, in addition to it. how to insulate attic.
When we are considering attic insulation, there are several factors that we should keep in mind. There are two main types of blow in attic insulation. These tw…
My download The Corinthian, Attic, and Lakonian pottery from Sardis for this effectiveness tells this: Why include we say to take between the implementation; mining; of 000e6 and the board; theology; of the targeted action? so of whether you are a transformation or a labor or a curation year, you agree had to control a structured T of service depth; an ministry of Jesus. answer of reigning an explanation - is a refusing analysis of Who you are digitizing. Seminary has a other dispersion and day for this to enjoy. Bill Hybels, Courageous Leadership( Grand Rapids: Zondervans, 2002) 253 partners, mentee. This download The Corinthian, Attic, and Lakonian pottery does designed from the knowledge. Bill Hybels relates into these films Structural weeks and significant P about great podcast that he means advised and interviews to be through his way with the Willow Creek Church and its environment. He ACTS other that the user-specified service is the number of the provision, but it has Incredible ...
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When Debra was diagnosed with a cholesteatoma, she knew it wasnt good. After all, she had a very invasive and very destructive tumor in her right ear. "I went from being able to partially hear in my right ear to being totally deaf in my right ear. I missed out so much on conversations even when they were right in front of me. The Baha System has been life-changing for me. For the first time in my life, I can hear in stereo. I can hear on both sides, and I can hear people talking to me even if there is noise in the background. I am looking forward to richer relationships - richer interactions with friends and family. And now, Im excited because I dont have to miss out on anything anymore.". ...
ENT Update 7th Feb 08 David Strachan ENT Consultant, Bradford Royal Infirmary Basic Questions 1. Draw a normal eardrum 2. What normal structures can you see up a nose 3. What is a cholesteatoma 4. What
|b||p||b|This pretty French Jumeau Bebe comes from an attic found in the near of Paris . She is on size 11 beautiful Bebe with very fine creamy bisque , original body and wig and has deep modeling of on early Tete model.|b||p||b| 24 ( 61 cm ) doll with pale and creamy bisque socket head and best quality of painting. Large blue glass paperweight inset eyes with thick dark eyeliner and lushly painted lashes. Brush-stoked and multi- feathered brows and has on closed mouth with defined space between the shaded and outlined lips.|b||p| Pierced ears and nice brunette human hair wig over cork pate which is original to this doll. She has her original French composition and wooden fully jointed body with original body finish and straight wrists.|b||p||b| Note on very fine old hairline at one of her head side ..... please see my pictures ....very hard to see without lamp and complete covered by her wig. Otherwise free of damage , repair , chip or other bisque problem and mark at back ; Depose Tete Jumeau
When it comes to a homes attic, usually a lot of attention is paid to making sure that that particular space is insulated a well a possible.
Ultratouch. My personal experience with non toxic brands of insulation have led me to a favorite. It is "Ultratouch" by Bonded Logic,made from blue jean scraps. They make a duct insulation. I have had good luck with this company.. They claim their insulation can be used in a non-vented space, and I have tried that with success. But non-vented attics can cause moisture build up, and I notice the Green Home Guide staff in their excellent article "Buyers Guide to Green Insulation" do not recommend it for moisture prone areas. This makes sense, as it is made of cotton, which absorbs moisture.. ...
The Madwoman in the Attic trope as used in popular culture. This is when a character with mental problems, and often some physical deformity, is locked away …
Nicole and Michael Ranz found treasures in their attic far too valuable for a garage sale. In a house once owned by the Catholic Diocese of Rockfords first bishop, they found a private chapel that included an oil painting of the Virgin Mary and a stained-glass window picturing the Holy Spirit.
Q: I just got a bid for insulation of my 824-square-foot attic for $1,200. That seems pretty high. The contractor would blow in cellulose insulation. But you have said that expandable foam against the roof is better. Is the expandable foam you mentioned nontoxic?
A man should keep his little brain attic stocked with all the furniture that he is likely to use, and the rest he can put away in the lumber-room of his library, where he can get it if he wants it.
Q. I just got a bid for insulation of my 824-square-foot attic for $1,200. That seems pretty high. The contractor would blow in cellulose insulation.
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Bahija was the first person to arrive @ Attic that night. I arrived after Bahija and we were waiting for the rest of the people. Attic was very new to almost all of my frenz and this was the first time they went to this place. Moreover Attic is located in the housing area, its not located @ the bangsar bar area. Bahija and I was looking @ our mobile... as expected, our mobile phone kept ringing that night. Everytime my friend arrived, i would need to run down to meet them... the Attic sign was too small to be noticed. Anyway, no one lost their way ...
How To Declutter Your Attic-check out this listing of declutter tips. Whether youre selling your home or want more space,decluttering an attic is a big...
Details about the mold resistance benefits of cellulose insulation when you work with chicagoland insulation experts Green Attic Insulation.
I think you did very well in addressing how to cut back on the AC. Just as I think you missed one, I kept on reading and found it. If we had known how much cooler our house would have been with a big front porch added on (because need necessitated a wheelchair ramp be added) we would have done it years ago. This house is more than 100 years old, and we finally added central heat and air about 7 years ago. We did with fans, especially an attic fan. Even with no AC, the attic fan would most nights pull in enough cool air that we actually pulled up blankets on the bed even when the prior day was stifling. The attic fan was on from 9 or 10 at night until 6 to 8 the next morning. You leave the windows open to pull the maximum amount of air in the rooms you want. More open bedroom windows, only cracks in living areas that are not used at night. Usually made the house bearable until late afternoon, and then you knew it would cool. Small fans all over the house help too. And if you have a bowl of ice ...
I was eight years old when attended St Hildas Church of England School. It was December 1945 and Mrs Duckworth was our teacher in class 2b, and it was the day of our school Christmas party, I still remember the day well. My twin sister, Joyce, and I shared an attic bedroom and as soon as I awoke that morning remembered it was the Christmas party. It was so cold in the attic that morning that the window was covered in ice. I crawled out of bed and felt the shock of my feet on the cold attic floor. Quickly I pulled the large hand pricked rug from the bed onto the floor and sank my toes into the warmth.. Mam had made the rug last winter on a large frame in front of the living room fire. Within the rug could make out the vestiges of the red material from our lovely red coats which had too been made by Mam, this time on her treadle sewing machine. How Joyce and I loved those coats, but alas they were now too small for us, at least now, along with some of our other old clothes they were having an ...
Just had whole home DVR and Internet installed. Installer put my 16 port SWM on the outside wall by the dish along with a green label splitter. I...
Barrier spraying. These barriers can come in spray or solid form and need to be applied directly on the walls, floors, roof. The barrier stops the radiant heat from entering your attic.. Insulation. Insulation regulates the heat transfer from the lower to the upper levels and also with the outside. It will help you keep your house warm in the winter and cold in the summer.. Ventilation. Ventilation is very important as it keep your attic moisture free and it also pulls the heat out. If the levels of moisture are low, then mildew and mold cannot grow and you should have any insulation problems.. ...
Everybody knows that colour is one to make an attractive room design, of the most significant facets. . Color is definitely a vital component for producing or remodeling models, thus choosing the shades that are right have to be carefully considered.
http://www.powerlogic.com/literature/EnergyMeter_3020HO0002R908.pdf. Currently playing with this sub-panel meter in my studio apartment. If I can tie it into a network of some sort, I can remotely monitor the power use. Even better, I might post my power usage stats to a web-page so that I can see historical data on my consumption.. Do I use more power on Tuesdays or Wednesdays?. Is this high efficiency AC really worth it?. To exactly how many dollars per hour does a 90 degree equate?. ...
So, the ghosts have formed a greeting committee outside. Is it a warning-off committee or welcoming committee? I think the latter; they do babble on a lot in a friendly way. The photos show the string taped in place. The porch roof will mask the wires on the ground floor, and the Washington 2.0 has a nice overhang on the upper floor where the wires can be tucked away. Tomorrow I have to figure out how the string will be fastened. Im thinking a series of two small holes drilled in the porch roof and the attic floor where it overhangs, then a thin wire around the light wires and twist to fasten. The twisted bit wont be seen in the attic, and the twisted wire on the porch roof can probably be hidden under a shingle or masked with moss or a spider or something ...
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Like a magician she caught the shadowy apparitions of her brain and tossed them in startling picturesqueness to her friends, who charmed with their simplicity and homeliness as well as profundity, fretted that she so easily made palpable the tantalizi...
Ran across this pic which is about 4 years old. The customer called and said the a/c would quit cooling soon after it was worked on. The house was new, inspected by the city, and they had the original company out three times for the same problem. I saw the problem when I stuck my head in the attic. Aux pan switch was turning the system off, and I guess the company would clean the pan out on every trip. Hard to imagine... I just dont have words for this.
And today, our house is being insulated. Our house is 70 years old and besides the things weve done to it in the last 3 years it has had very very few upgrades. The time has come for insulation. It was kinda drafty but not anymore. And if youve never seen a standing house insulated, well then, you have missed a treat. They dont roll out the insulation. Oh no. It is sprayed in with this super long tube thing that kinda looks like a dryer vent. Its a pretty cool process. Clayton has loved watching men go in and out of the attic. And they have a "big truck" so hes impressed by that ...
For years the government has known that the attics and walls of as many as 35 million homes and businesses are insulated with Zonolite, which contains le...
We arrived at our summer home to find that mice had been living in the attic and walls during the winter. There is a large amount of urine and feces. From what ...
Nothing embodies the driving force behind our engineering process than these five words: Designed Simple, Built to Last. The origin of our design theory is rooted in our own origins. I started in the same place many of you did, running a rig in hot attics, cramped crawl spaces, and windy roofs fighting with equipment t
Keep your home healthy by protecting against heat and moisture problems in the attic. HGTVRemodels shares the fundamentals of roof ventilation on HGTV.com.
On July 29 we moved into our new digs, a freshly renovated home by Rockhold Creek in Deale. It s pretty grand, considering we ve moved from a cozy little nook by Tri-State Marine s service and showroom depot to a two-story abode complete with glassed-in porch, pine plank floors and a water view. Our yellow Lab office dog Max finally has plenty of room to spread out without tripping the casual production floor pedestrian and we, as he, couldn t be happier. Even the writers are allowed to benefit, as we ve been moved to a writer s loft in the finished attic ...
Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear and mastoid cavity. More about Chronic Suppurative Otitis Media
The external auditory canal (EAC) is an unusual location for a cholesteatoma. We present the cases of 2 patients with EAC cholesteatoma who experienced extensive damage that extended from the inferior EAC wall to the infratemporal area; there was no mastoid involvement. In both cases, the cholesteatomas were removed under local anesthesia and the inferior canal wall was reconstructed with a technique that involved the placement of a pedicled musculoperiosteal flap, a cartilage graft, and a full-thickness skin graft. This simple procedure preserves a normal EAC contour, middle ear space, and mastoid cavity.. ...
Chronic suppurative otitis media (CSOM) is persistent inflammation of the middle ear or mastoid cavity. it usually begins as a complication of persistent acute otitis media (AOM) with perforation in childhood. Typical findings may also include thickened granular middle ear mucosa and mucosal polyps [17]. The worldwide prevalence of CSOM is 65 to 330 million persons, and 39 to 200 million (60%) of those individuals has clinically significant hearing impairment [17]. The definitive treatment of CSOM is by surgery (tympanoplasty and/or mastoidectomy), nevertheless, initial treatment by ear toilet and ototopical agents is necessary to prepare the ear for surgery. The selection of local or systemic antibiotic for therapy depends greatly on the type of the organism isolated in such cases. In the present study, Pseudomonas aeruginosa was the most commonly isolated bacterial pathogen followed by Klebsiella, Staphylococci, Diphtheroids and Acinetobacter. Additionally, mixed bacterial infection was ...
RESULTS Twenty patients had labyrinthine lesions. Six patients had viral labyrinthitis, one patient had bacterial labyrinthitis, and one patient had luetic labyrinthitis. Three patients had hemorrhage in the labyrinth, two posttraumatic and one spontaneous from an adjacent temporal bone tumor. Only one of the two patients with traumatic labyrinthine hemorrhage had evidence of a fracture on high-resolution CT. In one patient with CT-proved cochlear otosclerosis, peri-cochlear foci of enhancement were seen on contrast-enhanced MR. Four patients had presumed labyrinthine schwannomas. A middle ear cholesteatoma in one patient invaded the cochlea and resulted in marked cochlear enhancement due to granulation tissue. Thirteen patients had intracanalicular and cerebellopontine angle lesions. The lesions included arteriovenous malformations (three patients), sarcoidosis (three patients), metastasis (two patients), lymphoma (two patients), lipomas (two patients), and postshunt meningeal fibrosis (one ...
External auditory canal cholesteatomas are an uncommon locations for cholesteatomas, which are usually in the middle ear or petrous apex. When they occur lateral to the tympanic membrane, they are referred to as external auditory canal cholestea...
Mario Sannas Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma is the ultimate illustrated guide to complete management of the cholesteatoma, including assessment of the full expansion and degree of destruction caused by the growths, and short- and long-term follow-up to assess and treat for recurrence ...
Chronic suppurative otitis media (CSOM) can be particularly difficult to treat as a number of patients do not respond to routine antibiotic or surgical treatments. The current treatment involves administering combination antibiotic anti-inflammatory ear drops such as Ciprodex (ciprofloxacin 0.3% / dexamethasone 0.1%). Although most patients experience a relief of symptoms, a fraction of patients remain refractory to treatment. Recent findings suggest that the addition of N-acetylcysteine (0.5-2%) to Ciprodex is a superior treatment for otitis media with effusion compared to the use of Ciprodex alone ...
Smelly ear discharge - Malodorous ear discharge - Cholesteatoma - Cholesteatoma treatment - Cholesteatoma Symptoms - Cholesteatoma Definition - Mastoidectomy operation - Ear surgery in Istanbul - Ear surgery in Turkey
Cholesteatoma Fibroblasts Promote Epithelial Cell Proliferation through Overexpression of Epiregulin. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A second-look procedure is sometimes performed to determine if a cancer patient has responded successfully to a particular treatment. Examples of cancers that are assessed during second-look surgery are ovarian cancer and colorectal cancer. In many cases, before a round of chemotherapy and/or radiation therapy is started, a patient will undergo a surgical procedure called cytoreduction to reduce the size of a tumor. This debulking increases the sensitivity of the tumor and decreases the number of necessary treatment cycles. Following cytoreduction and chemotherapy, a second-look procedure may be necessary to determine if the area is cancer-free. An advantage to second-look surgery following cancer treatment is that if cancer is found, it may be removed during the procedure in some patients. In other cases, if a tumor cannot be entirely removed, the surgeon can debulk the tumor and improve the patients chances of responding to another cycle of chemotherapy. However, second-look surgery cannot ...
Routine ENT surgeries- Tonsillectomy, Adenoidectomy and Grommet insertion Management of Salivary and Thyroid gland disease Management of Neck Swellings Management of Voice disorders including Microlaryngeal surgery (Phonosurgery) Management of Swallowing disorders Management of Snoring Management of Hearing, Tinnitus and Balance problems with Support from fully Qualified Clinical Audiologist and Hearing Aid Audiologist( Ms. Jean Hegarty) Ear surgeries include Tympanoplasty, Mastoidectomy and Combined approach tympanoplasty (cholesteatoma surgery) Management of sinus disease, nasal disease and allergic rhinitis Endoscopic Sinus surgery and Septoplasty ...
Attic Insulation Appleton Wi.Appleton WI Spray Foam Insulation Contractor Garage . Greater Appleton WI Attic Insulation Cellulose . Greater Appleton WI Attic Insulation Cellulose . Chair | Stool | Ottoman | Seat | Sofa | Couch | Bench
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Maxwells Attic is an independent service that is supported by advertising. Most of the offers that appear on this site are from companies which Maxwells Attic receives compensation.. The third-party product names, logos, brands, and trademarks shown on this website are the property of their respective owners. These companies are not affiliated with Maxwells Attic and do not sponsor or endorse any giveaways. ...
Literature Review of the Impact and Need for Attic Ventilation in Florida Homes Authors Parker, Danny Original Publication Danny, Parker, Literature Review of the Impact and Need for Attic Ventilation
Just about all of us have felt the pain of receiving high summer utility bills. Yes, that includes the Doug Rye household.. I am still receiving lots of calls about hot attics. So, I am devoting a third column to that subject. I will use examples of the callers questions and my responses to those questions in the hope that it will answer your questions.. In almost every hot attic conversation, we talk about insulation. As you probably already know, we nearly always recommend either -cellulose or foam insulation. We feel that cellulose is the "greenest" insulation of the two and is usually lower in price. However, in many cases, foam is easier to install and can be the best answer to the problem. Almost every person asks about foam, so let me give you a short history of it.. As best as I can determine, a German chemist named Otto Bayer invented a type of foam in the late 1930s. It was then introduced in the United States in the 1940s and used primarily for military and aviation purposes. When ...
Are you venturing into your attic or storage space to pull out your holiday décor? Be careful with attics and asbestos exposure. Heres what to know.
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... Myringoplasty is the procedure done to close central perforations in patients with safe type or tubotympanic type of chronic suppurative ottitis media. It is not done in case of cholesteatoma which o
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
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Souther Salazars paintings return us to a childlike state of mind full of curiosity and belief that anything is possible. His animal characters traverse enchanted dreamworlds where abstract designs form different galaxies to explore. Salazar is preparing to debut his next solo show, "Attic Transmissions," which will be on view at Narwhal Contemporary in Toronto March 28 through April 25. He describes his new work as an exercise in spontaneity. Many of the drawings began as fragments and notes in sketchbooks that the artist cobbled together over time. Over the months he worked on the show, he carried around a suitcase full of drawing supplies and archival materials to make his creative process as seamless as possible with his daily life.. "I wanted to allow the possibility of making art that can unfold at anytime… Like little ghosts, or seeds carried by the wind, the opportunity to channel these intangible moments of inspiration can be elusive and fleeting," Salazar writes of his process. By ...
Pink Panther Attic Insulation R Values.Insulation Services Fort Lauderdale . Insulation. Residential Insulation Thermafiber. Best Gallery Images for Your Reference and Informations
Baffles prevent insulation from restricting air movement. While it may seem counterintuitive, even well-insulated attic spaces require air circulation. That means drawing air in from outside the home...
A unigue tropical collection to scrap your beautiful memories!. This product contains. 59 ellies. 14 papers (5 solids and 9 patterns). and 1 full sand alpha with uppercase, lowercase, numbers and some punctuation.. This product coordinates with. Just Another Day In Paradise: Frame Clusters. Just Another Day In Paradise: Borders &. Just Another Day In Paradise: Wordart. but if you want to have them all and SAVE. you can grab the bundle. ...
Hello everyone, I have noticed our home a little bit dusty (quickly) and figured I would pull off a supply register vent and put my finger in there and take a swipe...what did I find the cellulose that I remember when we blew it in. Not much, but enough of it to know what it is, not dust, etc...I had replaced the filter about a month ago, and already I have noticed a few cat balls of insulation in it! Before we blew in the cellulose, I spent hours in the attic with mastic tape, and foam
Some attic spaces werent designed well and trap the hot air that the sun is creating instead of letting it ventilate out of the house. Learn what to do.
Looking for online definition of mastoid air cell in the Medical Dictionary? mastoid air cell explanation free. What is mastoid air cell? Meaning of mastoid air cell medical term. What does mastoid air cell mean?
Introduction: Tympanoplasty for the surgical correction of chronic suppurative otitis media is one of the most comman ENT surgical procedures. This surgery can be done both under general anaesthesia and local anaesthesia with sedation. Dexmedetomidine is said to have both analgesic and sedative properties. The aim of this study is to compare the results of monitored local anaesthesia with dexmedetomidine with general anaesthesia in patients undergoing tympanoplasty to find out the better efficacious anaesthesia for this surgery. Methods: 100 patients were planned for tympanoplasty were taken up for this study. 50 patients were operated under general anaesthesia and remaining 50 patients were operated under monitored local anaesthesia with dexmedetomidine. The results were evaluated intraoperatively and postoperatively for duration of surgery, hemodynamic stability and complications. Patient s and surgeon s satisfaction was also evaluated. Results: The results showed that there was lesser ...
Malformations of the middle ear are classified as minor and major malformations. Minor malformations appear with regular external auditory canal, tympanic membrane and aerated middle ear space. The conducting hearing loss is due to fixation or interruption of the ossicular chain. The treatment is surgical, following the rules of ossiculoplasty and stapes surgery. In major malformations (congenital aural atresia) there is no external auditory canal and a deformed or missing pinna. The mastoid and the middle ear space may be underdevelopped, the ossicular chain is dysplastic. Surgical therapy is possible in patients with good aeration of the temporal bone, existing windows, a near normal positioned facial nerve and a mobile ossicular chain. Plastic and reconstructive surgery of the pinna should proceed the reconstruction of the external auditory canal and middle ear. In cases of good prognosis unilateral aural atresia can be approached already in childhood. In patients with high risk of surgical failure,
Chronic otitis media is characterized by the presence of intractable tissue pathology such as granulation tissue, fibrosis, cholesterol granuloma, cholesteatoma, ossicular erosin, or new bone formation, with or without associate middle ear effusion. This is the most serious form of otitis media and at present can only be corrected by surgical intervention.. The etiology of chronic otitis media is repeated episodes of the other forms previously described. Although this classification was previously based on the presence of a perforated tympanic membrane, it is currently accepted that chronic otitis media can exist behind an intact and normal appearing tympanic membrane "silent otitis media". The following are examples of chronic otitis media showing intractable tissue pathology.. ...
Objectives To identify the mucin gene and its expressing cells in the middle ear mucosa with chronic otitis media (COM), and to study the correlation between infiltration of inflammatory cells in the submucosa and expression of the mucin gene in the mucosal epithelium with COM.. Study Design Middle ear mucosal specimens removed from the inferior promontory area of 19 patients undergoing middle ear surgery for COM were studied.. Methods Sections were stained with H&E, Alcian blue-periodic acid Schiff (AB-PAS), polyclonal MUC5B antibody, and specific MUC5B riboprobe for histological, histochemical, immunohistochemical, and mucin mRNA analyses.. Results H&E staining revealed pseudostratified epithelia in 18 of the middle ear specimens with COM and cuboidal secretory epithelia in one. AB-PAS staining of epithelia revealed abundant secretory cells and their products (glycoconjugates). In situ hybridization and immunohistochemistry studies demonstrated that the secretory cells of the middle ear mucosa ...
Preservation of anatomic integrity and function of the cranial nerves during the removal of skull base tumors is one of the most challenging procedures in endoscopic endonasal surgery. It is possible to use intraoperative mapping and identification of the cranial nerves in order to facilitate their preservation. The purpose of this study was to evaluate the effectiveness of intraoperative trigger electromyography in prevention of iatrogenic damage to the cranial nerves. Twenty three patients with various skull base tumors (chordomas, neuromas, pituitary adenomas, meningiomas, cholesteatomas) underwent mapping and identification of cranial nerves during tumor removal using the endoscopic endonasal approach in Department of Neurooncology of Federal State Autonomous Institution
Table 2 of the article "Topical Fluoroquinolones for Eye and Ear" (October 15, 2000, page 1872) contained an error regarding the recommended use of the topical medication ciprofloxacin-hydrocortisone (Cipro HC). The table incorrectly states that Cipro HC, a nonsterile solution, is recommended for use in patients with acute otitis externa and acute otitis media with tympanic membrane perforation. According to the 55th edition of the Physicians Desk Reference, the use of Cipro HC is actually contraindicated in patients with a perforated tympanic membrane. However, the table correctly indicates that Floxin, a 0.3 percent sterile solution of ofloxacin, is indicated for use in patients with acute otitis externa, chronic suppurative otitis media with perforations and acute otitis media with tympanostomy tubes. The corrected table is reprinted above. ...

Expression of the epidermal growth factor system in human middle ear cholesteatoma - Danish National Research Database-Den...Expression of the epidermal growth factor system in human middle ear cholesteatoma - Danish National Research Database-Den...

... system in human middle ear cholesteatoma. Methods: Forty-seven patients referred for surgery due to cholesteatoma were included ... Expression of the epidermal growth factor system in human middle ear cholesteatoma. * ... Biopsies of cholesteatoma and skin from the external ear canal were obtained during surgery. mRNA expression was quantified ... HER4 mRNA could be detected in 50% of cholesteatoma and 20% of reference tissues, and the HER4 protein was detectable only in ...
more infohttp://www.forskningsdatabasen.dk/catalog/258704992

Mastoid air cell | definition of mastoid air cell by Medical dictionaryMastoid air cell | definition of mastoid air cell by Medical dictionary

As the cholesteatoma, middle ear effusion and granulation tissue all share CT numbers ranging from 40 to 60, only secondary ... In addition, there was soft-tissue thickening and oedema of the right external auditory canal, fluid in the middle ear and ... 5) Early diagnosis of the disease process can prevent the dreaded complications of the diseases of the middle ear and mastoid ... Computed tomography (CT) showed partial opacification of the left mastoid air cells and middle ear cavity and thickening of the ...
more infohttps://medical-dictionary.thefreedictionary.com/Mastoid+air+cell

Microbiology of Chronic Suppurative Otitis Media,Study of the Role of Bacterial Biofilm and Fungal Infection
 | MedCraveMicrobiology of Chronic Suppurative Otitis Media,Study of the Role of Bacterial Biofilm and Fungal Infection | MedCrave

Fungal infections of middle ear are common as fungi thrive well in moist pus. There is very little known about mycological ... CSOM is of two types, mucosal or tub tympanic type and cholesteatoma or atticoantral type [6]. Tub tympanic type affects mainly ... Fungal infections of middle ear are common as fungi thrive well in moist pus [14]. There is very little known about mycological ... Chronic suppurative otitis media (CSOM) is defined as chronic inflammation of middle ear cleft. The disease is common in all ...
more infohttp://googlescholar.medcraveonline.com/scholars/article_fulltext/1785

Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium.  - PubMed - NCBIActivation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium. - PubMed - NCBI

Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium.. Liu W1, Xie S1, Chen X1, Rao ... Immunohistochemistry was used to examine the expression of IL-6 and p-STAT3 in 25 human middle ear cholesteatoma samples and 15 ... Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium ... Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24551293

Role of CT and MRI in the Follow-Up of Operated Middle Ear CholesteatomaRole of CT and MRI in the Follow-Up of Operated Middle Ear Cholesteatoma

Recurrence is the main risk that may occur during the follow-up of operated middle ear cholesteatoma. Imaging plays an ... Four patients (11%) had cholesteatoma in both ears, while 22 (61%) had their left ear operated and 10 (28%) had the right ear ... Middle ear cholesteatoma.Ann OtolaryngolChirCervicofac 123: 120-137.. *Preciado DA (2012) Biology of cholesteatoma: Special ... Role of CT and MRI in the Follow-Up of Operated Middle Ear Cholesteatoma. Myriam Jrad, Farouk Graiess, Selma Behi, Rym ...
more infohttps://www.omicsonline.org/open-access/role-of-ct-and-mri-in-the-followup-of-operated-middle-ear-cholesteatoma-2161-119X-1000275.php?aid=81302

Diffusion Weighted MR Imaging of Primary and Recurrent Middle Ear Cholesteatoma: An Assessment by Readers with Different...Diffusion Weighted MR Imaging of Primary and Recurrent Middle Ear Cholesteatoma: An Assessment by Readers with Different...

... presence/absence of the middle ear cholesteatoma) defined as a noticeable hyperintensity in the middle ear region. Presence of ... the interobserver agreement was higher for recurrent cholesteatoma (. ; ) than for primary cholesteatoma (. ; ). No substantial ... the interobserver agreement was higher for recurrent cholesteatoma (. ; ) than for primary cholesteatoma (. ; ). On the other ... Figure 1: Images of primary cholesteatoma of the right middle ear cavity: (a) coronal SE T1w, (b) axial T2w TSE, (c) coronal ...
more infohttps://www.hindawi.com/journals/bmri/2015/597896/

IJMS | Free Full-Text | Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear ...IJMS | Free Full-Text | Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear ...

The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. ... There were 14 upregulated proteins in the epithelial tissues of cholesteatoma in comparison with retroauricular skin. The ... they are very likely involved in the proliferation of keratinocytes in cholesteatoma. Upregulations of GRP75, GRP78 and GRP94 ... maps of the epithelial tissues of 12 attic cholesteatomas with those of retroauricular skins. ...
more infohttp://www.mdpi.com/1422-0067/14/7/14439

IJMS  | Free Full-Text | Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear ...IJMS | Free Full-Text | Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear ...

The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. ... There were 14 upregulated proteins in the epithelial tissues of cholesteatoma in comparison with retroauricular skin. The ... they are very likely involved in the proliferation of keratinocytes in cholesteatoma. Upregulations of GRP75, GRP78 and GRP94 ... maps of the epithelial tissues of 12 attic cholesteatomas with those of retroauricular skins. ...
more infohttp://www.mdpi.com/1422-0067/14/7/14439/htm

Pseudoaneurysm of the Petrosal Internal Carotid Artery in the Middle Ear as a Complication of Middle Ear CholesteatomaPseudoaneurysm of the Petrosal Internal Carotid Artery in the Middle Ear as a Complication of Middle Ear Cholesteatoma

Cholesteatoma Cholesteatoma, Middle Ear Ear, Middle Embolization, Therapeutic Follow-Up Studies Humans Stents Temporal Bone ... Pseudoaneurysm of the Petrosal Internal Carotid Artery in the Middle Ear as a Complication of Middle Ear Cholesteatoma. ... Middle ear Cholesteatoma MeSH Terms expand_less. expand_more. Aged Aneurysm, False Angiography Carotid Arteries Carotid Artery ... The patient had middle ear cholesteatoma, and computed tomography (CT) showed bony erosion and exposure of the ICA into the ...
more infohttps://koreamed.org/article/2180JAO/2015.19.1.58

Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma - Thieme.de - Thieme Webshop - Mario Sanna, Hiroshi...Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma - Thieme.de - Thieme Webshop - Mario Sanna, Hiroshi...

Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma. Mario Sanna Hiroshi Sunose Fernando Mancini Alessandra ... Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma extends Mario Sannas passionate dedication to excellence ... Mario Sannas Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma is the ultimate illustrated guide to ... The key reference dedicated to surgery for cholesteatoma.... The cholesteatoma, strictly speaking a cyst and not a cancer, ...
more infohttps://www.thieme.de/shop/HNO-Heilkunde/Sanna-Sunose-Mancini-Russo-Taibah-Microsurgical-Management-of-Middle-Ear-9783132000056/p/000000000308200101?categoryCode=100107

Cholesteatoma of middle ear - Explain Medicine | Medical JoyworksCholesteatoma of middle ear - Explain Medicine | Medical Joyworks

Congenital cholesteatoma of middle ear may manifests in young ages as a whitish mass in the middle ear with intact tympanic ... Congenital cholesteatoma of middle ear may manifests in young ages as a whitish mass in the middle ear with intact tympanic ... Cholesteatoma is found to be frequently associated with middle ear infections like chronic otitis media.,.. History of otitis ... Cholesteatoma can be result from metaplasia of the middle ear mucosa or implantation following trauma or even after surgery... ...
more infohttps://www.medicaljoyworks.com/explain-medicine/catalog/Otorhinolaryngology/Cholesteatoma-Of-Middle-Ear

First Branchial Cleft Fistula Associated with External Auditory Canal Stenosis and Middle Ear CholesteatomaFirst Branchial Cleft Fistula Associated with External Auditory Canal Stenosis and Middle Ear Cholesteatoma

Case Report: This report features a rare case of microtia and congenital middle ear and canal cholesteatoma with first ... External auditory canal stenosis was complicated by middle ear and external canal cholesteatoma, but branchial fistula, opening ... should be considered that canal stenosis in such cases can induce cholesteatoma formation in the auditory canal and middle ear. ... This report features a rare case of microtia and congenital middle ear and canal cholesteatoma with first branchial fistula. ...
more infohttp://ijorl.mums.ac.ir/article_3218.html

Overexpression of placenta growth factor in human middle ear cholesteatoma<...Overexpression of placenta growth factor in human middle ear cholesteatoma<...

... and participates in the neoangiogenesis of cholesteatoma. Objectives. Middle ear cholesteatoma is characterized by the presence ... and participates in the neoangiogenesis of cholesteatoma. Objectives. Middle ear cholesteatoma is characterized by the presence ... and participates in the neoangiogenesis of cholesteatoma. Objectives. Middle ear cholesteatoma is characterized by the presence ... and participates in the neoangiogenesis of cholesteatoma. Objectives. Middle ear cholesteatoma is characterized by the presence ...
more infohttps://koreauniv.pure.elsevier.com/en/publications/overexpression-of-placenta-growth-factor-in-human-middle-ear-chol

Postoperative Aeration in the Middle Ear and Hearing Outcome After Canal Wall Down Tympanoplasty With Soft-Wall Reconstruction...Postoperative Aeration in the Middle Ear and Hearing Outcome After Canal Wall Down Tympanoplasty With Soft-Wall Reconstruction...

No significant differences were observed in postoperative middle ear aeration or hearing outcome between the 2 cholesteatoma ... Postoperative middle ear aeration was significantly greater in the smaller gap bins (0-10 and 11-20 dB) compared with the ... Postoperative middle ear aeration was scored 1 year after second-stage surgery by computed tomography. The patients were ... in the Middle Ear and Hearing Outcome After Canal Wall Down Tympanoplasty With Soft-Wall Reconstruction for Cholesteatoma. ...
more infohttps://insights.ovid.com/otneu/200906000/00129492-200906000-00008

Facial Nerve | Ear, Nose & Throat JournalFacial Nerve | Ear, Nose & Throat Journal

Hemifacial spasm secondary to middle ear cholesteatoma June 28, 2018 , Maheep Sohal, MD; Nicholas Karter, MD; Marc Eisen, MD, ... In middle ear surgery, endoscopy is a valuable instrument for second-look procedures in cholesteatoma. ... In rare cases, hemifacial spasm is caused by middle ear pathology. We... ...
more infohttps://www.entjournal.com/category/head-and-neck/facial-nerve

Shogo ShinoharaShogo Shinohara

Clinical evaluation of congenital cholesteatoma of the middle ear].. Authors:. Masahiro Kikuchi Etsuo Yamamoto Shogo Shinohara ... Preoperative diagnosis and surgical strategy in congenital auditory ossicular malformation of 26 ears].. Authors:. Yuji ...
more infohttps://www.pubfacts.com/author/Shogo+Shinohara

KAKEN - Research Projects | Pathogenesis of adhesive otitis media and study of mechanism of development into the pars tensa...KAKEN - Research Projects | Pathogenesis of adhesive otitis media and study of mechanism of development into the pars tensa...

Publications] Masanori Shiwa, et al: Role of cytokines in Epidermal proliferation of middle ear cholesteatoma Cholesteatoma ... Publications] Masanori Shiwa: Role of Cytokines in Epidermal Proliferation of Middle Ear Cholesteatoma Cholesteatoma and ... In addition, the level of gas exchange through the middle ear membranes and changes in middle ear pneumatic pressure according ... Publications] Hiromi Kojima, et al: Role of Bcl-xL protein in differentiation and apoptosis of human middle ear cholesteatoma ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671761/

2020 ICD-10-CM Type 2 Excludes Crosswalk, Page 7/152020 ICD-10-CM Type 2 Excludes Crosswalk, Page 7/15

Cholesteatoma of middle ear. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Type 2 Excludes*cholesteatoma of external ... Cholesteatoma of middle ear. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Type 2 Excludes*cholesteatoma of external ... Other disorders of middle ear mastoid. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Type 2 Excludes*mastoiditis (H70 ... Cholesteatoma of external ear. 2016 2017 2018 2019 2020 Non-Billable/Non-Specific Code Applicable To*Keratosis obturans of ...
more infohttps://www.icd10data.com/ICD10CM/Analytics/Type2_Excludes_Crosswalk/7

Otitis Media | SpringerLinkOtitis Media | SpringerLink

Infection of the middle ear causes not only generally known inflammatory changes but also others peculiar to the site. Otitis ... Middle ear cholesteatoma: an animal model. Am J Otolaryngol 1985; 6:327-341PubMedCrossRefGoogle Scholar ... Congenital cholesteatoma of the middle ear and mastoid: a third report. Arch Otolaryngol. J 1973;97:177-182CrossRefGoogle ... Ruedi L. Cholesteatoma formation in the middle ear in animal experiments. Acta Otolaryngol (Stockh) 1959; 50:233-242CrossRef ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4471-0235-9_3

Causes of Facial Numbness | Livestrong.comCauses of Facial Numbness | Livestrong.com

Cholesteatoma, a noncancerous middle ear tumor. *Pituitary gland tumor. *Certain drugs, such as cocaine and the gout medication ... Mandibular nerve -- lower lip and chin, cheek and temple area near the front of the ear, external ear, lining of the lower ... Acoustic neuroma, a noncancerous tumor of the nerve that carries signals betweeen the inner ear and brain, can cause facial ... numbness and weakness along with hearing loss, ringing in the affected ear and a spinning sensation. ...
more infohttps://www.livestrong.com/article/133474-causes-face-numbness/

Thrombosed Dural Sinus Malformation in a Fetus: A Case Report.Thrombosed Dural Sinus Malformation in a Fetus: A Case Report.

6492968 - Bilateral congenital middle ear cholesteatomas.. 12072798 - Microgastria-limb reduction anomaly with total amelia.. ...
more infohttp://www.biomedsearch.com/nih/Thrombosed-Dural-Sinus-Malformation-in/24593318.html

Otology Flashcards by Brian McCalister | BrainscapeOtology Flashcards by Brian McCalister | Brainscape

Absence of mucosa on the promontory, in most of the middle ear, or in the middle ear cleft (except in the eustachian tube). ... How do the surgical findings differ during removal of a congenital cholesteatoma from removal of a cholesteatoma associated ... One will enter the middle ear first in the epitympanum; the facial nerve will always lie medial to the ossicular heads in the ... Pneumocephalus; torn dura can create a ball valve-like effect and trap air from the middle ear. Influx of air may occur during ...
more infohttps://www.brainscape.com/flashcards/otology-5508519/packs/8316217

Cholesteatoma | pathology | Britannica.comCholesteatoma | pathology | Britannica.com

... ear disease: Chronic middle-ear infection: …by a condition known as cholesteatoma of the middle ear. This is an ingrowth of ... skin from the outer-ear canal that forms a cyst within the middle ear. An infected cholesteatoma cyst enlarges slowly but ... In ear disease: Chronic middle-ear infection. …by a condition known as cholesteatoma of the middle ear. This is an ingrowth of ... skin from the outer-ear canal that forms a cyst within the middle ear. An infected cholesteatoma cyst enlarges slowly but ...
more infohttps://www.britannica.com/science/cholesteatoma

Kaltschmidt B[au] - PubMed - NCBIKaltschmidt B[au] - PubMed - NCBI

Stem cells in middle ear cholesteatoma contribute to its pathogenesis.. Nagel J, Wöllner S, Schürmann M, Brotzmann V, Müller J ... Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Kaltschmidt+B%5Bau%5D&dispmax=50
  • To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma. (nih.gov)
  • The differential proteins were detected by comparing the two-dimension electrophoresis (2-DE) maps of the epithelial tissues of 12 attic cholesteatomas with those of retroauricular skins. (mdpi.com)
  • There were 14 upregulated proteins in the epithelial tissues of cholesteatoma in comparison with retroauricular skin. (mdpi.com)
  • The in situ hybridization technique has been used to determine the mechanism of epithelial proliferation in cholesteatoma, and cultured cell lines, mainly of fibroblasts and keratinocytes, have been analyzed at the protein and gene level. (nii.ac.jp)
  • Differentiation and apoptosis of the epithelial cells of cholesteatomas, particularly the effect of protein kinase C on differentiation, and the relationship between the interleukin converting enzyme family (ICE) and apoptosis are being investigated using molecular biological techniques. (nii.ac.jp)
  • The influence of KGF on differentiation markers or cell growth factors will also be analyzed in cultured cell lines to explain the mechanism of normal epithelial differentiation and cell growth inhibitors, and then to assess the possibility of conservative therapy for cholesteatoma. (nii.ac.jp)
  • Immunohistochemistry of sinus cholesteatomas showed that proliferating keratinocytes were very often found within epithelial cones growing towards the underlying stroma. (springer.com)
  • The aim of the present study was to provide evidence for the establishment of sinus cholesteatoma, defined as postero-superior pars tensa retraction extending into the posterior tympanum and tympanic sinuses. (springer.com)
  • The prevalence of pars tensa pathology was between 9.2 and 24% of investigated ears. (springer.com)
  • The great challenge of therapy is to eradicate the pathologic growth while preserving hearing and other critical functions of the middle ear and petrous bone, respecting the proximity of vital neural and vascular structures, and the intricate three-dimensional relationships involved. (thieme.de)
  • Mario Sanna's Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma is the ultimate illustrated guide to complete management of the cholesteatoma, including assessment of the full expansion and degree of destruction caused by the growths, and short- and long-term follow-up to assess and treat for recurrence. (thieme.de)
  • Microsurgical Management of Middle Ear and Petrous Bone Cholesteatoma extends Mario Sanna's passionate dedication to excellence in otologic teaching and training into this highly complex surgical area. (thieme.de)
  • The cholesteatoma, strictly speaking a cyst and not a cancer, nevertheless shows expansive and destructive growth patterns that may give rise to serious symptoms and consequences, including fatality, not unlike those seen for malignant neoplasms. (thieme.de)
  • 7 . Barkdull GC, Carvalho D. Goldenhar syndrome with external auditory canal stenosis complicated by canal cholesteatoma and first branchial cleft cyst. (ac.ir)
  • This is an ingrowth of skin from the outer-ear canal that forms a cyst within the middle ear. (britannica.com)
  • Upregulations of GRP75, GRP78 and GRP94 in keratinocytes may be able to counter endoplasmic reticulum stress, to inhibit cell apoptosis, to prevent protein unfolding and to promote cholesteatoma growth. (mdpi.com)
  • Our findings suggest that MSh TSE DWI has higher sensitivity for detection of cholesteatoma and lower probability of misdiagnosis. (hindawi.com)
  • Abstract Conclusion: The detection of the HER4 receptor in 50% of cholesteatomas but never in the reference tissue, and the increased expression of its activating ligand EPI, suggest that EPI-mediated activation of HER4 might play a role in cholesteatoma growth. (forskningsdatabasen.dk)
  • The detection of HPV in cholesteatomas is still no proof for their causal role in the development of cholesteatomas. (egms.de)
  • In particular, diffusion weighted imaging (DWI) can be helpful, since the high content of keratin of cholesteatoma is associated with restricted diffusion [ 2 , 3 ]. (hindawi.com)
  • Only few investigations on the prevalence of HPV-DNA in cholesteatomas have hitherto been reported. (egms.de)
  • As in our study even the prevalence of HPV in cholesteatomas was very low their causal relationship with the development of cholesteatomas seems to be very doubtful. (egms.de)
  • External auditory canal stenosis was complicated by middle ear and external canal cholesteatoma, but branchial fistula, opening in the zygomatic root and a sinus in the helical root, may explain this feature. (ac.ir)
  • It should be considered that canal stenosis in such cases can induce cholesteatoma formation in the auditory canal and middle ear. (ac.ir)
  • 10. Yalcin S, Karlidag T, Kaygusuz I, Demirbag E. First branchial cleft sinus presenting with cholesteatoma and external auditory canal atresia. (ac.ir)
  • Abstract Conclusion: We demonstrated that repression of keratinocyte growth factor (KGF) receptor (KGFR) could be a potentially useful strategy in the conservative treatment of middle ear cholesteatoma. (biomedsearch.com)
  • It can leads to gradual loss of hearing.The expanding sac may causes destruction of the ear drum and ossicles which may ultimately lead in to conductive type hearing loss. (medicaljoyworks.com)
  • It can be removed using two techniques depending on the size of the cholesteatoma and the damage done to the ossicular bones, the eardrum and the posterior wall of the ear canal [ 3 ]. (omicsonline.org)
  • Acoustic neuroma, a noncancerous tumor of the nerve that carries signals betweeen the inner ear and brain, can cause facial numbness and weakness along with hearing loss, ringing in the affected ear and a spinning sensation. (livestrong.com)
  • In in vitro studies, oxygen inhalation through the normal middle ear mucosa, and gas exchange associated with changes in hemodynamics caused by drugs, particularly changes in partial pressure of oxygen and changes in total pressure in the middle ear are being examined in rabbits. (nii.ac.jp)
  • Tos M, Bak-Pedersen K. Goblet cell population in the normal middle ear and Eustachian tube of children and adults. (springer.com)
  • The aims of our study were to evaluate the advantage of multi-shot turbo spin echo (MSh TSE) DWI compared to single-shot echo-planar (SSh EPI) DWI for the diagnosis of cholesteatoma. (hindawi.com)
  • Middle ear cholesteatoma is a common inflammatory disease requiring prompt surgical treatment to prevent local and intracranial complications due to the activation of osteoclastic function [ 1 ]. (hindawi.com)