Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
A plant genus of the family LILIACEAE that contains spirostanol & furostanol SAPONINS.
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as octane and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.
Detailed account or statement or formal record of data resulting from empirical inquiry.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A class in the phylum CNIDARIA, comprised mostly of corals and anemones. All members occur only as polyps; the medusa stage is completely absent.
Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.
A plant genus in the CHENOPODIACEAE family.
A plant genus of the family POACEAE. The seed is one of the EDIBLE GRAINS used in millet cereals and in feed for birds and livestock (ANIMAL FEED). It contains diosgenin (SAPONINS).

Archean molecular fossils and the early rise of eukaryotes. (1/103)

Molecular fossils of biological lipids are preserved in 2700-million-year-old shales from the Pilbara Craton, Australia. Sequential extraction of adjacent samples shows that these hydrocarbon biomarkers are indigenous and syngenetic to the Archean shales, greatly extending the known geological range of such molecules. The presence of abundant 2alpha-methylhopanes, which are characteristic of cyanobacteria, indicates that oxygenic photosynthesis evolved well before the atmosphere became oxidizing. The presence of steranes, particularly cholestane and its 28- to 30-carbon analogs, provides persuasive evidence for the existence of eukaryotes 500 million to 1 billion years before the extant fossil record indicates that the lineage arose.  (+info)

Gene transfection activities of amphiphilic steroid-polyamine conjugates. (2/103)

The design and evaluation of a novel potent class of DNA delivery agents based on steroid-polyamine conjugates bearing a flexible linker are reported. The hydrophobic regions are based on steroids, i.e. chlolestane and lithocholic acid motifs. The linker, which couples a hydrophobic steroid and a hydrophilic polyamine, in this study can be regarded as a two-atom extension of the conventional carbamate linker. We found that the gene transfection activity of the steroid-polyamine conjugates is influenced by the polyamine chain length and steroid structure. Molecular modeling of the relevant amphiphilic molecules revealed low-energy structures in which the polyamine chains are folded rather than stretched. This work suggests a significant effect of space-filling, i.e. the shape and orientation of the hydrophilic and hydrophobic regions, upon the efficiency of gene transfection.  (+info)

Biosynthesis of bile acids in man. Hydroxylation of the C27-steroid side chain. (3/103)

The first step in the degradation of the steroid side chain during biosynthesis of bile acids from cholesterol in man was studied in microsomal and mitochondrial fraction of homogenate of livers from 14 patients. The microsomal fraction was found to catalyze an efficient 25-hydroxylation of 5,8-cholestane-3a,7a,12atriol. A small extent of 23-, 24-, and 26-hydroxylation of the same substrate was observed. 53-Cholestane-3a,7adiol was hydroxylated in the 25-position only to a very small extent. The mitochondrial fraction was found to catalyze 26-hydroxylation of cholesterol, 5-cholestene-3P,7a-diol, 5P-cholestane-3a,7a-diol, 7a-hydroxy-4-cholesten-3-one, and 5,0-cholestane-3a,7a,12a-triol. Addition of Mg++ stimulated the 26-hydroxylation of cholesterol but had no effect or an inhibitory effect on 26-hydroxylation of the other substrates, indicating a heterogeneity of the mitochondrial 26-hydroxylating system. The level of 26-hydroxylase activity towards different substrates varied considerably with different mitochondrial preparations. The roles of the microsomal and mitochondrial 26- hydroxylations as well as the microsomal 25-hydroxylation in biosynthesis of bile acids in man are discussed. The results indicate that microsomal 26-hydroxylation is less important than mitochondrial 26-hydroxylation under normal conditions. The possibility that microsomal 25-hydroxylation is important cannot be ruled out.  (+info)

Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity. (4/103)

Further search for cytotoxic compounds contained in the bulbs of Galtonia candicans (Liliaceae) led to the isolation of four potent cytotoxic cholestane glycosides (1-4) based upon 3beta,16beta,17alpha-trihydroxycholest-5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a new rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents was carried out by spectroscopic analysis and a few chemical transformations.  (+info)

The role of a 5alpha-hydroxylated intermediate in the formation of the 5, 6-double bond in cholesterol biosynthesis. (5/103)

If the biological conversion of cholest-7-en-3beta-ol (I) into cholesterol (IV) occurred thorugh the intermediacy of cholest-7-ene-3beta,5alpha-diol (II) then the factor(s) adversely affecting the convwesion of the 5alpha-hydroxy sterol (II) into cholesterol must at least equally adversely affect the formation of cholesterol from cholest-7-en-3beta-ol. By using partial denaturation techniquws and dual-labelled precursors it was shown that the enzyme system responsible for the conversion of the 5alpha-hydroxy sterol (II) into cholesterol denatured faster than that for the corresponding conversion from cholest-7-en-3beta-ol (I).  (+info)

Four new 26-aminocholestane-type glycosides from Solanum abutiloides. (6/103)

From the fresh roots of Solanum abutiloides, four new 26-aminocholesteryl glycosides were obtained, and their structures were characterized by analysis of their spectra data, including two-dimensional (2D) NMR spectroscopy. These compounds were regarded as key intermediates in the biogenesis of steroidal alkaloids.  (+info)

Rapid transbilayer movement of spin-labeled steroids in human erythrocytes and in liposomes. (7/103)

The transbilayer movement and distribution of spin-labeled analogs of the steroids androstane (SLA) and cholestane (SLC) were investigated in the human erythrocyte and in liposomes. Membranes were labeled with SLA or SLC, and the analogs in the outer leaflet were selectively reduced at 4C using 6-O-phenylascorbic acid. As shown previously, 6-O-phenylascorbic acid reduces rapidly nitroxides exposed on the outer leaflet, but its permeation of membranes is comparatively slow and thus does not interfere with the assay. From the reduction kinetics, we infer that transbilayer movement of SLA in erythrocytes is rapid at 4C with a half-time of approximately 4.3 min and that the probe distributes almost symmetrically between both halves of the plasma membrane. We have no indication that a protein-mediated transport is involved in the rapid transbilayer movement of SLA because 1) pretreatment of erythrocytes with N-ethyl maleimide affected neither flip-flop nor transbilayer distribution of SLA and 2) flip-flop of SLA was also rapid in pure lipid membranes. The transbilayer dynamics of SLC in erythrocyte membranes could not be resolved by our assay. Thus, the rate of SLC flip-flop must be on the order of, or even faster than, that of probe reduction rate on the exoplasmic leaflet (half-time approximately 0.5 min). The results are discussed with regard to the transbilayer dynamics of cholesterol.  (+info)

Appetite suppression and weight reduction by a centrally active aminosterol. (8/103)

The rise in obesity and its complications has generated enormous interest in the regulation of feeding and body weight. We show that a spermine metabolite of cholesterol (MSI-1436) decreases body weight, specifically fat, by suppressing feeding and preventing the reduction in energy expenditure, hormonal changes, and patterns of neuropeptide expression normally associated with weight loss. MSI-1436 enters the brain after peripheral injection and is more potent when injected into the cerebral ventricle (intracerebroventricular [ICV]). Systemic or ICV MSI-1436 administration induced similar patterns of Fos immunoreactivity in the brain, especially the paraventricular hypothalamic nucleus (PVN). This brain region integrates neural signals from hypothalamic and brain stem nuclei and regulates feeding behavior, autonomic function, and neuroendocrine function. Microinjection of MSI-1436 into the PVN potently suppressed feeding and reduced body weight for several days. Unlike caloric restriction, MSI-1436 decreased mRNA levels of agouti-related peptide and neuropeptide Y in the hypothalamus. These findings indicate that MSI-1436 acts in the brain to regulate food intake and energy expenditure, likely through suppression of orexigenic hypothalamic pathways.  (+info)

3alpha,7alpha-Dihydroxy-5beta-cholestane + [Reduced NADPH---hemoprotein reductase] + Oxygen ,=, 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane + [Oxidized NADPH---hemoprotein reductase] + ...
S.; Hoshita, N.; Okuda, K.: Enzymatic characteristics of CO-sen - sitive 26-hydroxylase system for 5b-cholestane-3a,7a,12a-triol in rat-liver mitochondria and its intramitochondrial localization.. Recently Uploaded Slideshows. ...
Cholestane glycosides from Ornithogalum saundersiae bulbs and the induction of apoptosis in HL-60 cells by OSW-1 through a mitochondrial-independent signaling pathway (2019 ...
Sterols: Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
triglycerides-207.20,LDL cholesterol-65.26,VLDL cholesterol-41.44 please advise me Hello Swati, I read your message carefully and understood your medical
Spawns only during daytime (Ref. 27547). At spawning, males lie close to the bottom in the current of the spawning area while females stay along the banks and in still water (Ref. 27547). A female moves from the bank of the stream usually escorted by 2-4 males to the spawning area at the center of the stream. The males crowd beside her; egg deposition occurs as the males try to clasp the female with their pelvic fins or vibrate against her with their anal fins. This spawning act lasts for 3-5 seconds and may occur as often as 6-40 times per hour. After the eggs are deposited, the sexes separate and return to their previous stream positions (Ref.1998). Fish that moved out of a lake to spawn generally return to the lake a few days after spawning. However, river-resident fish may stay on or near the spawning area for much of the summer (Ref. 27547). Many spawn in two or even three consecutive years but others may skip one or two years between spawning (Ref. 10928). ...
During diagenesis and catagenesis, the biological stereospecificity of sterols, particularly at C-5, C-14, C-17 and C-20 is usually lost, and a large range of isomers is generated (see above for numbering). The term alphabetabeta sterane (sometimes just alphabeta) is commonly used as short-hand to denote steranes with the 5alpha(H), 14beta(H), 17beta(H) configuration, while alphaalphaalpha sterane would denote 5alpha(H), 14alpha(H), 17alpha(H) stereochemistry. The notation 14alpha(H) indicates that the hydrogen is located below the plane of the paper, whereas in 14beta(H) it is above the plane. In steranes, if no other carbon number is cited, S and R always refer to the stereochemistry at C-20. The prefix nor, as for example in 24-norcholestane, indicates that the molecule is formally derived for the parent structure by loss of the indicated carbon atom, i.e. C-24 is removed from cholestane. The term desmethylsteranes is sometimes used to distinguish steranes that do not possess an ...
Squalamine, a 7,24 dihydroxylated 24-sulfated cholestane steroid conjugated to a spermidine at position C-3. This steroidal compound was initially found in tiss
Nazole ring, hence the signal on the proton H 9 in the 1 H NMR spectra of all compounds appeared in the narrow range (7.51.71 ppm). Introduction of NO2 group on the phenyl ring A, which has negative inductive and unfavorable resonance impact, caused downfield shift of Ristomycin Epigenetics signals of all protons in the ring in comparison to signals of corresponding protons inside the 1 H NMR spectra of compounds from set 1. Also, chemical shift of H 7 protons was impacted by this substitution, exactly where for all compounds from set two, with NO2 group in ortho-position, important shift to reduce field was observed. Introduction of methyl group around the phenyl ring B, that is electron donating group by induction, triggered shielding effect of all protons from the ring B, where signals of protons H 13 and HC15 were the most affected within the 1 H NMR spectra of all methyl derivatives. The electronic effects of methoxy group, which can be a withdrawer by induction and an electron donor by ...
The 11 Malagasy species of the genus Ecnomus McLachlan, 1864 that do not belong to the psychomyiellodes species group are studied. One of them (Ecnomus salgiel Malicky, 2015) was recently described from Nosy Be Island. Ten are new and described: Ecnomus felix n. sp., E. dobignyi n. sp., E. matsaboryi n. sp., E. granjoni n. sp., E. commersoni n. sp., E. menavavae n. sp., E. ikopaensis n. sp., E. ru ...
Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver ...
A novel sulfur-containing sterane, 4,7-epithio-5-cholestane, has been identified in a sediment extract from the Miocene Northern Apennines marl (Italy) after its isolation by column chromatography and high pressure liquid chromatography. The compound has been characterised by GC-MS and mild Nickel boride desulfurisation and one and two-dimensional 1H NMR techniques. C27-C29 ... read more homologs have been detected in sediment extracts of three different formations and in one petroleum sample. These sulfur-containing steroids are A novel sulfur-containing sterane, 4,7-epithio-5-cholestane, has been identified in a sediment extract from the Miocene Northern Apennines marl (Italy) after its isolation by column chromatography and high pressure liquid chromatography. The compound has been characterised by GC-MS and mild Nickel boride desulfurisation and one and two-dimensional 1H NMR techniques. C27-C29 homologs have been detected in sediment extracts of three different formations and in one ...
Steroidal saponins are plant metabolites with a broad range of biological activities (Hostettmann & Marston, 1995). They are composed by a glycoside and a triterpene or steroidal fragment. Hydrolysis of saponins provides a glycoside free portion termed sapogenin which can be of the cholestane, furostane or spirostane type. The spirostane sapogenins also display economic importance due to their application in the synthesis of biologically active compounds such as insect hormones (Lee et al., 1976) cephalostatins and ritterazines (Lee et al., 2009, Phillips & Shair, 2007 and Pettit et al., 1988). In previous studies we reported the preparation of epoxycholestane derivatives as useful intermediates in the synthesis of norbrassinosteroid analogues (Rincón et al., 2006), in continuation with our studies we report herein on the synthesis and crystal structure of the title compound, (I), obtained by treatment of the previously reported ...
Adults home to certain gravelly spawning streams. Two to four males crowd around a female and press against her with their fins. Eggs are scattered and adhere to the gravel or are carried downstream and adhere to the substrate when the water is calmer. The spawning act lasts for 3-4 seconds and may occur 6-40 times an hour (Ref. 1998). Spent adults return to the lake 10-14 days after spawning began. Most females return to the lake during the first half of the downstream migration followed by most males in the latter half. Downstream fry migration occurs between dusk and dawn (Ref. 10928). ...
The present invention relates to a piperazine of the formula I wherein ring B is phenyl, pyridyl or pyrimidyl; each R3 is independently selected from hydrogen, halogen, N02, COOR wherein R is hydrogen or C1-6alkyl, CN, CF3, C1-6 alkyl, -S-C1-6 alkyl, -SO-C1-6 alkyl, -S02-C1-6 alkyl, C1-6 alkoxy and up to CIO aryloxy, n is 1, 2 or 3; P is a direct bond; Ring A is piperazinyl; Both X2 and X1 are N; Y is -SO2-; Z is -N(OH)CHO and Q is CH2; R1 is H, C1-6 alkyl, C5-7 cycloalkyl, up to C10aryl, up to C10aryl, up to C10heteroaryl, up to C12heteroarylalkyl, all optionally substituted by up to three groups independently selected from NO2, CF3, halogen, C1-4alkyl, carboxy (Cl-4) alkyl, up to C6 cycloalkyl, -OR4, -SR4, Cl-4 alkyl substituted with -OR4, SR4 (and its oxidized analogues), NR4, N-Y-R4, or Cl-4 alkyl-Y-NR4, with the proviso that where Rl is -OH, -OR4, -SR4, or NR4, or N-Y-R4 then Z is not -N(OH)CHO, Rl is 2, 3, 4, 5, 6-pentafluorophenyl; R4 is hydrogen, C1-6 alkyl, up to C10 aryl or up to C10 ...
Triglycerides also play an important role in clearing the toxins from the blood, as in cases of severe sepsis! (So high TGs means its a normal response to infection ...
Thus, the two substrates of this enzyme are cholest-5-ene-3β,7α-diol and NAD+, whereas its 3 products are 7α-hydroxycholest-4-en-3-one, NADH, and H+. The systematic name of this enzyme class is cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7 or HSD3B7 which is encoded by the HSD3B7 gene.[2][3] ...
Additions of one to two equivalents of Lewis acids that include magnesium salts to free-radical reduction reactions involving ester functionalized radicals and (1R,2S,5R)-menthyldiphenyltin hydride 4, bis((1R,2S,5R)-menthyl)phenyltin hydride 5, tris((1R,2S,5R)-menthyl)tin hydride 6, bis((1R,2S,5R)-menthyl)-[8-(N,N-dimethylamino)naphthyl]tin hydride 12, bis((1R,2S,5R)-menthyl)-[1-((S)-N,N-dimethylaminoethyl)phenyl]tin hydride 13 or 3α-dimethylstannyl-5α-cholestane 14 result in remarkable enantioselectivities. Examples include (S)-naproxen ethyl ester 16, produced in 74% yield and greater than 99% ee at −78°C from the bromide and 5 in the presence of MgBr2, and ethyl (R)-N-trifluoroacetyl-D-phenylglycinate 18, obtained in 78% yield and 99% ee under identical conditions. Kinetic and computational studies provide insight into the origins of these observations ...
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As part of our PowerVR Graphics SDK v3.2 release, were announcing a public developer support and feedback system for PowerVR Insider members.
There are six different stakeholder groups you should be listening to periodically to determine whether youre moving in the right direction. These six groups are:. 1. Customers: How your customers see you is critical to any organization. Since not all feedback systems work equally to uncover customer perceptions, you should use a variety of feedback systems. Some examples are suggestion cards, phone calls, emails, interviews, focus groups, and so on.. 2. Employees: You should to track your employees level of engagement and satisfaction. Again, you should use a variety of feedback systems to gauge their perceptions. Your employees have a big impact on your long-term performance, especially when youre trying to execute changes in strategy.. 3. Vendors: In the old world, companies didnt care what their vendors thought of them. But in the new world, everyone is connected and part of a greater whole. In developing flexibility with your strategy, all of your relationships are potential assets that ...
In order to maintain specific internal conditions, organisms use feedback mechanisms. Feedback is essential to the regulation of internal...
Feedback Systems An Introduction for Scientists and Engineers Karl Johan Åström Richard M. Murray Version v2.1b (February 22, 29) This is the electronic edition of Feedback Systems and is available from
This application was developed to help a marketing department in a Fortune 500 company deploy a "knowledge management" application to manage and
The module introduces the topic of feedback control systems and presents methods of modelling that lead to transient, steady state and stability performances in control systems. An emphasis is placed on links between time responses and complex frequency domains. Principal topics are feedback systems, Bode, Nyquist and root-locus analysis, stability conditions and compensation design. The overall aim is to understand and be able to apply basic techniques for the analysis and design of feedback control systems.. ...
Feedback Systems contains a set of running examples that are used throughout the text. These examples have been chosen to span multiple application areas of feedback and control systems. The links below go to dedicated pages for each running example, where you can find a summary of the example and additional information beyond what is in the text. ...
Hello all interested, I will start off by giving a overview of the function desired by the final design. The goal is to create a feedback system that...
27-Hydroxylase deficiency (cerebrotendinous xanthomatosis (CTX)) is a rare familial sterol storage disease with accumulation of cholestanol and cholesterol in most tissues, and in particular in xanthomas, bile, and brain. Clinically, this disorder is characterized by dementia, spinal cord paresis, cerebellar ataxia, tuberous and tendon xanthomas, early atherosclerosis, and cataracts.. More than 20 different mutations have been defined in the sterol 27-hydroxylase gene of CTX patients. The defect leads to a block in bile acid biosynthesis, with accumulation of substrates for the mitochondrial 27-hydroxylase such as 5β-cholestane-3α,7α,12α-triol and 7α-hydroxy-4-cholestene-3-one. The former metabolite is metabolized into 5β-cholestane-3α,7α,12α,25-tetrol, 5β-cholestane-3α,7α,12α,23-tetrol, and 5β-cholestane-3α,7α,12α,24,25-pentol.. These bile alcohols are excreted in gram amounts in bile and feces. At least part of the excess cholestanol in patients with CTX is formed from the ...
Effect of bile acids on DNA synthesis by the regenerating liver was investigated in mice in vivo after partial hepatectomy (PH). Radioactivity incorporation into DNA after [14C]thymidine intraperitoneal administration peaked at 48 h after PH. At this time a significant taurocholate-induced dose-dependent reduction in DNA synthesis without changes in total liver radioactivity content was found (half-maximal effect at approximately 0.1 mumol/g body wt). Effect of taurocholate (0.5 mumol/g body wt) was mimicked by chocolate, ursodeoxycholate, deoxycholate, dehydrocholate, tauroursodeoxycholate, taurochenodeoxycholate, and taurodeoxycholate. In contrast, chenodeoxycholate, glycocholate, glycochenodeoxycholate, glycoursodeoxycholate, glycodeoxycholate, 5 beta-cholestane, bromosulfophthalein, and free taurine lacked this effect. No relationship between hydrophobic-hydrophilic balance and inhibitory effect was observed. Analysis by high-performance liquid chromatography indicated that inhibition of ...
Variants in the cholesterol ester transfer healthy protein and also lipoprotein lipase genes are predictors of plasma cholesterol feedback to dietary change. A meta-analysis of 67 regulated trials of nutritional soluble fiber as a single intervention revealed that the effects on complete cholesterol as well as LDL cholesterol levels were small. An extensive review of plant get more info stanols as well as sterols showed that these materials lower LDL cholesterol degrees in persons at danger of coronary heart disease.15 This evaluation included a meta-analysis of 41 trials revealing that 2 g per day of either stanols or sterols lowers LDL cholesterol levels by 10 percent. Exec Summary of the Third Report of the National Cholesterol Education and learning Program (NCEP) Expert Panel on Discovery, Assessment, and also Treatment of High Blood Cholesterol in Grownups (Grownup Treatment Panel III). Private irregularity in cardiovascular condition risk element feedbacks to low-fat as well as ...
Variants in the cholesterol ester transfer healthy protein as well as lipoprotein lipase genes are predictors of plasma cholesterol feedback to nutritional modification. A meta-analysis of 67 controlled trials of nutritional soluble fiber as a single intervention revealed that the impacts on total cholesterol and LDL cholesterol degrees were small. An extensive evaluation of plant stanols as well as sterols showed that these compounds lower LDL cholesterol degrees in persons at danger of coronary heart disease.15 This testimonial included a meta-analysis of 41 tests showing that 2 g each day of either stanols or sterols decreases LDL website cholesterol degrees by 10 percent. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Specialist Panel on Discovery, Assessment, and also Treatment of High Blood Cholesterol in Grownups (Grownup Therapy Panel III). Specific irregularity in cardiovascular condition risk aspect responses to low-saturated-fat and also ...
318027337 - EP 2153025 A2 2010-02-17 - REAL TIME CLOSED LOOP INTERPRETATION OF TUBING TREATMENT SYSTEMS AND METHODS - [origin: WO2008152599A2] A technique facilitates the treatment of a subterranean formation. The technique involves the use of a fluid delivery system that comprises a continuous feedback system. The continuous feedback system utilizes a real time closed loop interpretation technique to instantaneously synchronize and adjust actions at a well site surface relative to measured downhole events. Sensors are used to monitor at least one downhole property in real time. Based on the real time data, the continuous feedback system enables adjustments to be made with respect to the at least one property in a manner designed to influence a downhole event.[origin: WO2008152599A2] A technique facilitates the treatment of a subterranean formation. The technique involves the use of a fluid delivery system that comprises a continuous feedback system. The continuous feedback system utilizes a real time
Basically what im asking is that does it involve the hypothalamus or pituitary gland etc. as the control centre? (If it involves one). Is the message gone to there (CNS) where it comes back to say, the liver or pancreas to issue a response ...
Four new steroidal components (1−4) along with two known analogues (5−6) were obtained from the roots and rhizomes of Smilacina henryi. The components structures were determined as (25S)-5α-spirost-9(11)-ene-3β, 17α, 21-triol (1), (24S, 25S)-5α-spirost-9(11)-ene-3β, 17α, 24-triol (2), (25S)-5α-spirost-9(11)-ene-3β, 17α-dihydroxy-12-one (3), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione (4 ...
Dr. Sutherland responded: Make an egg. The role of the ovaries is to make an egg each month which has the potential to be fertilized making an embryo, and then to support implantation of the embryo. The ovaries do this by producing an ebb and flow of hormones that interact with the pituatary gland in a complex feedback system. If implantation does not occur, the hormones decline, signaling a period to start.
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27-Deoxy-5b-cyprinol is an intermediate in Bile acid synthesis pathway, in a sequence of reactions catalyzed by sterol 27-hydroxylase (CYP27) in the oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,27-tetrol into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid (PMID: 8496170 ). 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol 3-glucuronide, a metabolite of 27-Deoxy-5b-cyprinol, is the major bile alcohol component in serum from cerebrotendinous xanthomatosis patients (PMID: 7920441 ...
Illustration of a Lithocholic Acid molecular model. Recent research has shown that lithocholic acid (LCA), which is naturally produced in the liver during digestion, can kill several types of cancer cells, including those found in some brain tumours and breast cancer. Key: black=carbon, white=hydrogen, red=oxygen. - Stock Image C022/4469
The body uses two different feedback systems to help maintain homeostasis. One is used to strengthen a system while the other reduces the output of the system. Briefly describe the two feedback system, choose two body systems and.
There is a similar and slightly extended version of this post on the blog I have on the POZ website. Its in two parts: Part 1 Part 2 HIV infection and
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
This is a word you will encounter a lot, and means equilibrium. The body maintains equilibrium through feedback systems, the nervous system, signaling molecules (hormones), and various receptor cells which monitor temperature, blood pressure, blood glucose, and many other things ...
Image by digitalART2 via Flickr In Robert Sapolskys book, Why Zebras Dont Get Ulcers, he details a biological feedback system wherein psychological stress leads to the release of glucocorticoids that have beneficial effects in the near-term but negative effects (e.g. ulcers, depression, etc.) in the long-term. The key to getting the near-term benefits and avoiding…
Homeostasis regulates the heart rate and all of its internal functions to maintain equilibrium. According to Biology Online, homeostasis uses a negative and positive feedback system to keep the human...
Seven new polyoxygenated steroids (1-7) were isolated together with seven known analogues (8-14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity.
Seven new polyoxygenated steroids (1-7) were isolated together with seven known analogues (8-14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity.
Cerebrotendinous xanthomatosis (CTX) is a rare, disabling genetic disorder in which cholestanol and cholesterol accumulate in the nervous system and other tissues. It has an autosomal recessive mode...
0038] Referring to, for example, FIG. 3C, in the exemplary embodiment, the motors 40, 42 may have suitable position feedback systems 50, 52. The position feedback systems 50, 52 may be non-invasive with respect to the isolated atmosphere in the transport chamber, as will be described below. The feedback system 50, 52 for motors 40, 42 may be generally similar to the feedback system 150, 152 shown in FIG. 6. The feedback systems 150, 152 for each rotor may be similar to each other and may generally incorporate sensors 150A, 150G, 1501 and target indexing to establish absolute and incremental rotational position, as well as radial or centered position of the rotor 140R, 142R. In alternate embodiments, the sensors 150A, 150G, 1051 may provide feedback information for any one or more of the absolute and incremental rotational position and the radial position. For example, the sensors 150A, 150G, 1501 may be electromagnetic sensors such as Hall effect sensor, or may be optical or other beam sensors. ...
A steroid is an organic compound with four rings arranged in a specific molecular configuration. Examples include the dietary lipid cholesterol, the sex hormones estradiol and testosterone and the anti-inflammatory drug dexamethasone. Steroids have two principal biological functions: certain steroids (such as cholesterol) are important components of cell membranes which alter membrane fluidity, and many steroids are signaling molecules which activate steroid hormone receptors. The steroid core structure is composed of seventeen carbon atoms, bonded in four fused rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxyl group at position three and a skeleton derived from cholestane. They can also vary more markedly by changes to the ring structure (for ...
The Salish Sucker is a freshwater fish and is under the responsibility of the federal government. The Species at Risk Act (SARA, Section 37) requires the competent minister to prepare recovery strategies for listed extirpated, endangered or threatened species. The Salish Sucker was listed as endangered under SARA in June 2005. The development of this recovery strategy was co-led by Fisheries and Oceans Canada - Pacific Region and the British Columbia Ministry of Environment, in cooperation and consultation with many individuals, organizations and government agencies, as indicated below. The strategy meets SARA requirements in terms of content and process (Sections 39-41) and the British Columbia Ministry of Environment has reviewed and accepts this document as scientific advice. Success in the recovery of this species depends on the commitment and cooperation of many different constituencies that will be involved in implementing the directions set out in this strategy and will not be achieved by
Catalog #: P2010002 - 250 U Cholesterol oxidase is a flavoprotein involved in the first step of cholesterol catabolism. The enzyme first oxidizes cholesterol to cholest-5-en-3-one then isomerizes it to cholest-4-en-3-one while producing hydrogen peroxide H2O2. Available in a 250 Units and custom bulk sizes. Live Enquiry about this product via Text/SMS: 1-858-900-3210 (8 am - 8 pm PST ...
한국 최고의 가격 Source Naturals Mega Strength Beta Sitosterol - 60 정제 부터 eVitamins.com. 알다 Mega Strength Beta Sitosterol 리뷰, 부작용, 쿠폰 및 eVitamins에서 더. 한국에 빠르고 신뢰할 수있는 운송. Mega Strength Beta Sitosterol 다른 제품으로 Source Naturals 당신의 건강 요구에.
If it is tripping because of a run away current, what ballast resistance are you using in your fusor circuit? My system would surge over 100 ma at startup but I had a simple x-former and diodes so not an issue; I did have a ballast resistor in my circuit and it was both the ohm and wattage Richard recommended but a fusor can act much as a dead short for a fraction of a second. That can trip any feedback system for PS that have that feature so that might be the issue ...
If it is tripping because of a run away current, what ballast resistance are you using in your fusor circuit? My system would surge over 100 ma at startup but I had a simple x-former and diodes so not an issue; I did have a ballast resistor in my circuit and it was both the ohm and wattage Richard recommended but a fusor can act much as a dead short for a fraction of a second. That can trip any feedback system for PS that have that feature so that might be the issue ...
The new AKM2G servo motors will be available with different feedback system choices, mounting /shaft options, connector designs, thermal sensor selections, shaft seal options, winding selections for different voltage and /or speed requirements and a brake option.
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19-Norpregnane Cholestane Nor- "Steroids". The Chemistry of Natural Products. The Chemistry of Natural Products. 1993. pp. 140- ...
Cholestane About biomarkers [email protected] Accessed 8 October 2009. v t e. ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholane Cholestane Lanostane Glotter, E. (1991). "Withanolides and related ergostane-type steroids". Natural Product Reports. 8 ... However simpler forms do exist, such as the sterane campestane (24R-methylcholestane). Along with cholestane and stigmastane, ...
Biomarker Cholestane Nor- Holba, A. G.; Dzou, L. I. P.; Masterson, W. D.; Hughes, W. B.; Huizinga, B. J.; Singletary, M. S.; ...
Biomarker Cholestane Nor- Holba, A. G.; Dzou, L. I. P.; Masterson, W. D.; Hughes, W. B.; Huizinga, B. J.; Singletary, M. S.; ... 24-Norcholestane is a 26-carbon (C26) sterane created from the removal of carbon 24 from cholestane. It has been found that 24- ...
... s are derivatives of cholestanes that have a double bond. If there are two double bonds, the molecule is known as a " ...
Androstane Cholestane Nor- Bao JP, Li MW (2001). "Unprecedented occurrence of novel C26-C28 21-norcholestanes and related ...
5α-Cholane 5β-Cholane Cholestane Ergostane Kurauti, Yukiti; Kazuno, Taro (January 1939). "Tetraoxycholan, Trioxycholen und ...
Major examples include tetrahydrodeoxycorticosterone (THDOC), the androstane 3α-androstanediol, the cholestane cholesterol and ... and the cholestane 24(S)-hydroxycholesterol (NMDA receptor-selective; very potent). Pheromones are neurosteroids that influence ...
A related and important molecule is 24-n-propyl cholestane (figure 1, right), also with the cholestane skeleton, but with an n- ... However, as with the marine algae, analysis of the ratio of 24-isopropyl cholestane to 24-n-propyl cholestane may clarify the ... can be decoupled by considering the ratio of 24-isopropyl cholestane to 24-n-propyl cholestane. In many rocks, this ratio is ... and the ratio of 24-isopropyl cholestane to 24-n-propyl cholestane is used an age-specific proxy for the Proterozoic- ...
... is a triterpene, also known as 4,4,14-trimethyl-9,19-cyclo-5alpha,9beta-cholestane. Its derivative cycloartenol is ...
Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholestane. Steroids can also ... the steroid is said to have a cholestane framework. The two common 5α and 5β stereoisomeric forms of steroids exist because of ...
These include terpenoids, terpenes, pristane, phytane, cholestane, chlorins and porphyrins, which are large, chelating ...
Cholestane Ergostane (24S-methylcholestane) Campestanol (Campestan-3β-ol) Yakimchyk VS, Kazlova VV, Hurski AL, Savchenko RG, ...
... , also known as 5β-cholestane, is a steroid and a parent compound of a variety of steroid derivatives, such as ...
Alternatively, it can be converted into 5β-cholestane-3α,7α-diol and then to chenodeoxycholic acid, the other major primary ...
... rearrangement is a classic organic reaction in organic chemistry describing a rearrangement reaction of cholestane-3β,5α,6β- ...
The molecular formula C27H48 (molar mass: 372.67 g/mol, exact mass: 372.3756 u) may refer to: Cholestane Coprostane, or 5β- ... cholestane 1,3,5-Triheptylbenzene This set index page lists chemical structure articles associated with the same molecular ...
... but the chemical 5β-cholestane-3-one has been shown to be fully competitive with it. Caterpillars readily follow trails of this ...
5-alpha cholestane, perylene, benzoperylene, coronene, tetradecylprene, dodecyl sulfide, benzodiphenylene sulfide, ...
5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase EC 1.14.13.97: taurochenodeoxycholate 6α-hydroxylase EC 1.14.13.98: ...
For cholestane specifically, diagenesis of cholesterol to cholestane produces a molecule that is fully saturated compared to ... However, cholestane is not exclusively derived from diagenesis of animal-derived biomolecules; cholestane has also been ... Additional diagenetic processes can further alter the cholestane molecule. For instance, cholestane is susceptible to ... but cholestane can be found in the fossil record with many stereochemical configurations. Cholestane in the fossil record is ...
7-Dehydrocholesterol is the precursor of cholecalciferol.[8] Within the epidermal layer of skin, 7-dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB light at wavelengths between 290 and 315 nm, with peak synthesis occurring between 295 and 300 nm.[32] This results in the opening of the vitamin precursor B-ring through a conrotatory pathway making previtamin D3 (pre-cholecalciferol).[33] In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] antarafacial sigmatropic rearrangement [34] and therein finally isomerizes to form vitamin D3. The active UVB wavelengths are present in sunlight, and sufficient amounts of cholecalciferol can be produced with moderate exposure of the skin, depending on the strength of the sun.[32] Time of day, season, and altitude affect the strength of the sun, and pollution, cloud cover or glass all reduce the amount of UVB exposure. Exposure of face, arms and legs, averaging 5-30 minutes twice per week, may be ...
... , also known as vitamin D2 and calciferol, is a type of vitamin D found in food and used as a dietary supplement.[1] As a supplement it is used to prevent and treat vitamin D deficiency.[2] This includes vitamin D deficiency due to poor absorption by the intestines or liver disease.[3] It may also be used for low blood calcium due to hypoparathyroidism.[3] It is used by mouth or injection into a muscle.[2][3]. Excessive doses can result in increased urine production, high blood pressure, kidney stones, kidney failure, weakness, and constipation.[4] If high doses are taken for a long period of time, tissue calcification may occur.[3] It is recommended that people on high doses have their blood calcium levels regularly checked.[2] Normal doses are safe in pregnancy.[5] It works by increasing the amount of calcium absorbed by the intestines and kidneys.[4] Food in which it is found include some mushrooms.[6]. Ergocalciferol was first described in 1936.[7] It is on the World Health ...
Biosynthesis of 24-isopropyl cholestane precursors in various rhizaria[9] suggests a relevant ecological role already during ...
For cholestane specifically, diagenesis of cholesterol to cholestane produces a molecule that is fully saturated compared to ... However, cholestane is not exclusively derived from diagenesis of animal-derived biomolecules; cholestane has also been ... Additional diagenetic processes can further alter the cholestane molecule. For instance, cholestane is susceptible to ... but cholestane can be found in the fossil record with many stereochemical configurations. Cholestane in the fossil record is ...
Other names: Cholestane, (5«alpha»)-; 5«alpha»-Cholestane; «alpha»-Cholestane; 28,29,30-Trinorlanostane; 10,13-Dimethyl-17-(1, ... 5-dimethylhexyl)-hexadecahydrocyclopenta(a)phenanthrene; 5A-Cholestane, TMS; 17-(1,5-Dimethylhexyl)-10,13-dimethyl-hexahydro- ...
Other names: 5«alpha»,14«beta»-Cholestane; C27 5A,14B,17B,20S-Sterane ...
S.; Hoshita, N.; Okuda, K.: Enzymatic characteristics of CO-sen - sitive 26-hydroxylase system for 5b-cholestane-3a,7a,12a- ... enzyme was re - named into 27-monooxygenase because it hydroxylates the methyl group in position 27 [7]) [7] 5b-cholestane-3a, ... cholestane-3a,7a,12a-triol + NADPH + O2 ...
5-seco-4-nor-cholestane, and in particular 3,5-seco-4-nor-cholestane oxime vis-à-vis the peroxidation of lipids and also vis-à- ... USE OF AT LEAST ONE OXIME DERIVATIVE OF 3,5-SECO-4-NOR-CHOLESTANE AS ANTIOXIDANTS ... This is why a subject of the present invention is the use of at least one oxime derivative of 3,5-seco-4-nor-cholestane as an ... This is why a subject of the present invention is the use of at least one oxime derivative of 3,5-seco-4-nor-cholestane or one ...
The Major Cholesterol Metabolite Cholestane-3β,5α,6β-Triol Functions as an Endogenous Neuroprotectant. Haiyan Hu, Yuehan Zhou, ... Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite of cholesterol, is an endogenous neuroprotectant and ... The Major Cholesterol Metabolite Cholestane-3β,5α,6β-Triol Functions as an Endogenous Neuroprotectant ... The Major Cholesterol Metabolite Cholestane-3β,5α,6β-Triol Functions as an Endogenous Neuroprotectant ...
3a,7a-Dihydroxy-5b-cholestane. Description. 3alpha,7alpha-Dihydroxy-5beta-cholestane is an intermediate in bile acid synthesis ... 3a,7a-Dihydroxy-5b-cholestane + NADPH + Oxygen → 3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane + NADP + Water. details. ... Showing metabocard for 3a,7a-Dihydroxy-5b-cholestane (HMDB0006893). IdentificationTaxonomyOntologyPhysical propertiesSpectra ... Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane- ...
5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 5beta-cholestane-3alpha,7alpha,12alpha-triol ... 5beta-cholestane-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol ... 5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating) ... Information on EC 1.14.14.139 - 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase. for references in articles please use ...
3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane. Description. 3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane, also known as (25R ... 3a,7a-Dihydroxy-5b-cholestane + NADPH + Oxygen → 3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane + NADP + Water. details. ... 5beta-cholestane-3alpha,7alpha,26-triol or (3alpha,5beta,7alpha)-cholestane-3,7,26-triol, belongs to the class of organic ... Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane- ...
Printing tips! To print chromatograms full page, change the print settings in the print dialogue window of your PDF reader software: 1) "fit" or "fit to page", 2) "landscape" for wide chromatograms or "portrait" for tall chromatograms.. ...
... cholestane explanation free. What is cholestane? Meaning of cholestane medical term. What does cholestane mean? ... Looking for online definition of cholestane in the Medical Dictionary? ... Cholestane , definition of cholestane by Medical dictionary https://medical-dictionary.thefreedictionary.com/cholestane ... cholestane. Also found in: Wikipedia. cho·les·tane. (kōles-tān), The parent hydrocarbon of cholesterol. For structure, see ...
5-alpha-Cholestane is the non-hydroxy, hydrogenated form of cholesterol and is useful as an internal standard for studies ... 5-alpha-Cholestane is the non-hydroxy, hydrogenated form of cholesterol and is useful as an internal standard for studies ... 5-alpha-Cholestane. Move your mouse over image or click to enlarge ...
24-Ethyl-cholestane-3ß, 5α, 6α-triol) is an oxysterol developed by our group. Besides its high antitumor potential, it has been ... Patients received daily 10 mg/kg of oral (24-ethyl-cholestane- 3ß, 5α, 6α-triol) divided in 3 equal doses, until disease ... A cholesterol derivative (24-ethyl-cholestane- 3β,5α,6α-triol ) with antitumor activity in advanced refractory or recurrent ... 950P - A cholesterol derivative (24-ethyl-cholestane- 3β,5α,6α-triol ) with antitumor activity in advanced refractory or ...
24-ethyl-cholestane- 3ß,5α,6α-triol) is an oxysterol developed by our group. Besides its high antitumor potential, it has been ... According to these excellent results, (24-ethyl-cholestane- 3ß,5α,6α-triol) seems to be a good candidate for phase II trials in ... A new non-chemo and non-toxic drug (24-ethyl-cholestane- 3β, 5α, 6α-triol) with antitumor activity in advanced refractory or ... Patients received daily 10 mg/kg of oral (24-ethyl-cholestane- 3ß,5α,6α-triol) divided in 3 equal doses every day, until ...
Cholestanes, Ergostanes, Withanolides, Stigmastane und Buchbewertungen gibt es auf ReadRate.com. Bücher können hier direkt ...
19-Norpregnane Cholestane Nor- "Steroids". The Chemistry of Natural Products. The Chemistry of Natural Products. 1993. pp. 140- ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes: 24S-Hydroxycholesterol. *Cholesterol. *Pregnanes: 3α-Dihydroprogesterone. *3β-Dihydroprogesterone ...
Cholestanes. *Cholestenes. *Cytochrome P-450 CYP2C8 Inhibitors. *Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
This page contains information about certified reference standard 5-β-CHOLESTANE and its Steroids. Purchase 5-β-CHOLESTANE ... This page contains information about 5-β-CHOLESTANE Cas 481-20-9 and its Steroids. 5-β-CHOLESTANE 5-β-CHOLESTANE Worldwide ... Do you want a quotation or have a question about 5-β-CHOLESTANE ? We normally respond within 2 hours. ... Pseudocholestane;Coprostane;Beta-Cholestane;(5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro ...
Cholestane. -. -. 2770. 0.23 ± 0.008. 3-Nonen-5-yne, 4-ethyl-, (Z). 1117. 11.22 ± 0.20. 1117. 11.14 ± 0.08. ...
Coles, S. J., Frampton, C. S., & Hursthouse, M. B. (2002). 5 ?-cholestane. Acta Crystallographica Section E Crystallographic ...
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CholestaneB. C27H48. 9. P21. 18. 0.0288. −0.01 (77). −0.04 (9). −0.01 (13). −0.02 (8). ... alanine and (b) cholestane. (c) as (b), but only the top 200 most influential points are shown; the axes are chosen to be the ... as illustrated in the plot for cholestane (Friedifstat = 9) in Fig. 1. (b). The least-squares fit for the data shown ...
5Beta-Cholestane molecule skeletal.png 2,245 × 1,000; 217 KB. *. 5Beta-Cholestane molecule spacefill.png 2,000 × 1,132; 488 KB ...
cholestane-3beta,5alpha,6beta-triol. LNCaP. DU-145. PC-3. Skp2. Akt1. c-Myc. FAK. EMT markers. beta-actin. alpha-tubulin. Micro ... Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells ... Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells. ... Oxysterols are oxidation products of cholestane-3β, 5α, 6β-triol (abbreviated. as triol) is one of the most abundant and active ...
Cholestanes [D04.808.247]. *Cholestenes [D04.808.247.222]. *Dihydrotachysterol [D04.808.247.222.387]. *Ergocalciferols [D04.808 ...
Cholestanes [D04.808.247]. *Cholestenes [D04.808.247.222]. *Cholecalciferol [D04.808.247.222.159]. *Hydroxycholecalciferols [ ...
glaucasterol: from soft coral Sarcophyton glaucum; natural C27 sterol with cyclopropane ring in side chain; structure given in first source
  • 5) These steroids have stigmastane (C29), cholestane (C27) and ergostane (C28) skeletons, respectively. (thefreedictionary.com)
  • Cholestane and spirostane glycosides from the rhizomes of Dioscorea septemloba. (semanticscholar.org)
  • Yokosuka A, Takagi K, Mimaki Y. New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity. (webmd.com)
  • The three plants illustrated in the article are bulbous perennials, and are considered to be poisonous, as they contain Cholestane glycosides and calcium oxalate. (microscopy-uk.org.uk)
  • 3alpha,7alpha-Dihydroxy-5beta-cholestane is an intermediate in bile acid synthesis. (hmdb.ca)
  • Presence of cholestane in environmental samples are commonly interpreted as an indicator of animal life and/or traces of O2, as animals are known for exclusively producing cholesterol, and thus has been used to draw evolutionary relationships between ancient organisms of unknown phylogenetic origin and modern metazoan taxa. (wikipedia.org)
  • Cholesterol has 256 stereoisomers, but only one of them is formed naturally in production of cholesterol (3β-ol, 5α (H), 14α (H), 17α (H), 20R) and is therefore the primary stereoisomer of interest for cholestane measurements. (wikipedia.org)
  • For cholestane specifically, diagenesis of cholesterol to cholestane produces a molecule that is fully saturated compared to its steroid counterpart. (wikipedia.org)
  • Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite of cholesterol, is an endogenous neuroprotectant and protects against neuronal injury both in vitro and in vivo via negative modulation of NMDA receptors. (jneurosci.org)
  • He criticizes its failure to survey how the animals managed their sterol supplements with blood-cholesterol measurements, and the omission in the oxides dose of cholestane triol--a cholesterol oxide now known to be highly atherogenic. (thefreedictionary.com)
  • 5-alpha-Cholestane is the non-hydroxy, hydrogenated form of cholesterol and is useful as an internal standard for studies involving sterols.1 Cholesterol is a sterol that is essential for all animal life, being critical for membrane permeability and fluidity and for many cellular functions. (universalbiologicals.com)
  • The research team did not recover high levels of cholesterol from the Dickinsonia specimen (which would be expected if the fossils were only 3,000 years old), but trace levels of cholestane (which would be expected if the fossils were hundreds of millions of years old). (reasons.org)
  • Cholestane is a chemical derivative of cholesterol that is produced when cholesterol undergoes diagenetic changes. (reasons.org)
  • When the chemical properties of cholesterol and cholestane are considered, and given the preservation conditions of the Dickinsonia specimens, the interpretation that these materials were recovered from 588-million-year-old fossil specimens passes the physical exam. (reasons.org)
  • The major cholesterol metabolite cholestane-3? (jove.com)
  • Okuda, K.: Enzymatic characteristics of CO-sen - sitive 26-hydroxylase system for 5b- cholestane -3a,7a,12a-triol in rat-liver mitochondria and its intramitochondrial localization. (wordnik.com)
  • Okuda, K.: Isolation of rat liver mitochondrial ferredoxin and its reductase active in the 5b- cholestane -3a,7a,12a-triol 26 hydroxylase. (wordnik.com)
  • A new non-chemo and non-toxic drug (24-ethyl-cholestane- 3β, 5α, 6α-triol) with antitumor activity in advanced refractory or recurrent, mainly aggr. (esmo.org)
  • Oxysterols are oxidation products of cholestane-3β, 5α, 6β-triol (abbreviated as triol) is one of the most abundant and active oxysterols. (nthu.edu.tw)
  • Secondary objectives will be to evaluate the efficacy of VTS-270 to reduce plasma cholestane-3beta,5alpha,6beta-triol, an NPC1-specific pharmacodynamic biomarker, and to normalize the degree of liver injury. (clinicaltrials.gov)
  • Biochemical efficacy will be assessed by measurement of plasma cholestane-3beta,5alpha,6beta-triol and other biomarkers. (clinicaltrials.gov)
  • Cholestane triol is one of the three oxycholesterols and distinguished for having three atoms of oxygen added. (drbriffa.com)
  • Cholestane triol numbers amongst the most potent atherogens known to man. (drbriffa.com)
  • The effects of cholestane 3β, 5α, 6β-triol on intestinal epithelial crypt cells were investigated using the IEC-6 cell line. (go.jp)
  • Cholestane 3β, 5α, 6β-triol decreased SH groups (glutathione and protein SH) in the cell, and showed cytotoxicity in a time-dependent manner. (go.jp)
  • Although the concentration of cholestane 3β, 5α, 6β-triol used in this study (100 μM) was very high compared with that in plasma of experimental animals, cholestane 3β, 5α, 6β-triol did not show any cytotoxicity on IEC-6 cells without fetal calf serum (FCS). (go.jp)
  • Unknown components in FSC (not VLDL or LDL) were suggested to be associated with the cytotoxicity of cholestane 3β, 5α, 6β-triol. (go.jp)
  • Cholestane can be extracted from samples and measured on the GC/MS to quantify relative abundance to other organic compounds. (wikipedia.org)
  • These are compounds containing a 3-hydroxylated cholestane core. (hmdb.ca)
  • In previous studies, the compounds ergosterol, ergostane, and cholestane have been isolated from S. (thefreedictionary.com)
  • This rock formation has escaped deep burial and geological heating, making it all the more reasonable that compounds such as cholestanes could survive for nearly 600 million years. (reasons.org)
  • Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. (hmdb.ca)
  • Cholestane is made in low abundance by other organisms (e.g., rhodophytes), but because these other organisms produce a variety of sterols it cannot be used as a conclusive indicator of any one taxa. (wikipedia.org)
  • Potent growth inhibitory activity of a novel Ornithogalum cholestane glycoside on human cells: induction of apoptosis in promyelocytic lcukemia HL-60 cells. (thefreedictionary.com)
  • 8777839 ). Lathosterol oxidase (EC 1.14.21.6) is an enzyme that catalyzes the chemical reaction 5alpha-cholest-7-en-3beta-ol + NAD(P)H + H+ + O2 cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O. (hmdb.ca)
  • The residue was dissolved again in 2 ml hexane containing 0.2 mg/ml 5-[alpha] cholestane internal standard (IS) (Sigma, EUA). (thefreedictionary.com)
  • thus, the presence of cholestane suggests some trace of oxygen in the paleoenvironment. (wikipedia.org)
  • This stereochemical orientation is typically maintained throughout diagenetic processes, but cholestane can be found in the fossil record with many stereochemical configurations. (wikipedia.org)
  • Additional diagenetic processes can further alter the cholestane molecule. (wikipedia.org)
  • Cholestane is a saturated C-27 animal biomarker often found in petroleum deposits. (wikipedia.org)
  • Cholestane isomers will elute from the column based on molecular weight and various stereochemistry, which makes traditional mass spectrometry challenging due to close co-elution of isomers. (wikipedia.org)
  • Alternatively, one can measure cholestane using GC/MS/MS experiments which target the m/z fragment 217 (from molecular ion 372). (wikipedia.org)
  • A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3β-hydroxy group. (ebi.ac.uk)