Cholene derivatives with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. They must have two double bonds in the ring system.

New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. III. Biological activity. (1/6)

The A25822 antibiotic complex consists of seven biologically active factors. A comparative study of these factors determined that factor B possessed the greatest antifungal activity. The minimal inhibitory concentration of A25822B against isolates of Candida albicans was less than 0.3 similar to 5.0 mug/ml, Trichophyton mentagrophytes was inhibited at less than 0.0312 mug/ml. Other pathogenic fungi such as Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, Sporotrichum schenckii, and Microsporium gypseum were very susceptible to A25822B. Only limited antibacterial activity of A25822B was found. Parenteral or oral administration of 50 mg/kg of A25822B significantly extended the average survival time of mice infected with C. albicans. Doses of 20 mg/kg of A25822B caused a greater than ten-fold reduction in the number of Candida cells recovered from kidneys of infected mice. A solution of 0.5% or 0.25% A25822B applied topically was effective against an experimental dermatophyte infection on guinea pigs. A peak blood level of 3 mug/ml was achieved in mice following a 100 mg/kg dose of A25822B. Combination of A25822B with a polyene antibiotic in vitro showed antagonism.  (+info)

New azasteroidal antifungal antibotics from Geotrichum flavo-brunneum. I. Discovery and fermentation studies. (2/6)

Although Geotrichum species occur ubiquitously, antibiotic production by members of this genus has not previously been reported. The antibiotic complex designated A25822, consisting of one major and six minor structurally-related components active primarily against Candida and Trichophyton, represents a new family of naturally-occurring compounds. Approximately 90% of the antibiotic activity synthesized remained associated with the fungal cell mass, from which it was recovered by multiple methanolic extractions for quantitation. Antibiotic production was enhanced by tryptophan, iron, zinc, and high levels of dextrin.  (+info)

New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization. (3/6)

A novel group of antibiotics, comprising microbiologically-active structurally-related factors A25822A, B, D, H, L, M and N, produced by culturing Geotrichum flavo-brunneum NRRL 3862 under submerged aerobic fermentation conditions was isolated by extraction. The individual factors were separated and purified by chromatography and crystallization. The major factor, A25822B, a 15-aza-24-methylene-D-homocholestadiene is a white crystalline compound, C25H45NO. The antibiotics are highly active against fungi and marginally active against bacteria.  (+info)

Characterization of two steroidal ketones and two isoprenoid alcohols in dairy products. (4/6)

Two steroidal ketones, delta-4-cholesten-3-one and delta-3,-5-cholestadiene-7-one, were isolated and identified for the first time in anhydrous milk fat and in nonfat dry milk. Together with these, two isoprenoid alcohols, phytol and dihydrophytol, were identified in anhydrous milk fat. Their identities were established on the basis of chromatographic and mass spectral data and confirmed by comparison with authentic materials.  (+info)

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. (5/6)

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Quantification of high-density-lipoprotein cholesterol by precipitation with phosphotungstic acid/MgCl2. (6/6)

We evaluated the use of a modified phosphotungstic acid/MgCl2 precipitation procedure for the precipitation of apolipoprotein B-containing lipoproteins. Precipitation of these lipoproteins [very-low- and low-density lipoproteins, and lipoprotein (a)] is complete, with negligible coprecipitation of high-density lipoprotein subfractions (HDL1, HDL2, HDL3), even in hypertriglyceridemic sera. In comparison with ultracentrifugation, the precipitation method yields, on the average, values that are 0.17 mmol/L lower for cholesterol values but almost identical for apolipoprotein A-I and phosphatidylcholine. Looking for delta 3,5-cholestadiene formed from cholesterol in the precipitation residue, we used "high-performance" liquid chromatography and "high-performance" thin-layer chromatography and found none.  (+info)

Cholestadienes are a type of steroid that is derived from cholesterol and contains a double bond between the 7th and 8th carbon atoms in the steroid nucleus. They can be further classified into different types based on the location and configuration of additional double bonds in the molecule.

Cholestadienes are important intermediates in the biosynthesis of various steroid hormones, bile acids, and vitamin D. Abnormal levels of certain cholestadienes can indicate disruptions in steroid metabolism and have been associated with various medical conditions, such as liver disease, cancer, and genetic disorders affecting steroid synthesis.

It's worth noting that "cholestadienes" is a general term that refers to a class of compounds, and specific cholestadienes may have their own unique medical relevance and definition.

... cholestadienes MeSH D04.808.247.222.222.347 - cholestadienols MeSH D04.808.247.222.222.347.200 - dehydrocholesterols MeSH ...
... cholestadienes MeSH D04.808.247.222.222.347 - cholestadienols MeSH D04.808.247.222.222.347.200 - dehydrocholesterols MeSH ...
Cholestadienes D4.808.247.222.222 D4.210.500.247.222.222 Cholestadienols D4.808.247.222.222.347 D4.210.500.247.222.222.347 ...
Cholestadienes D4.808.247.222.222 D4.210.500.247.222.222 Cholestadienols D4.808.247.222.222.347 D4.210.500.247.222.222.347 ...
The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids. 2012 Nov; 77(13):1313-20 ...
Cholestadienes D4.808.247.222.222 D4.210.500.247.222.222 Cholestadienols D4.808.247.222.222.347 D4.210.500.247.222.222.347 ...
Cholestadienes Preferred Term Term UI T008057. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Cholestadienes Preferred Concept UI. M0004252. Registry Number. 0. Scope Note. Cholene derivatives with methyl groups at C-10 ... Cholestadienes. Tree Number(s). D04.210.500.247.222.222. Unique ID. D002774. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Cholestadienes Preferred Term Term UI T008057. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Cholestadienes Preferred Concept UI. M0004252. Registry Number. 0. Scope Note. Cholene derivatives with methyl groups at C-10 ... Cholestadienes. Tree Number(s). D04.210.500.247.222.222. Unique ID. D002774. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two ... Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two ...
Cholecystokinin N0000167414 Cholenes N0000171395 Cholera Toxin N0000170887 Cholera Vaccines N0000167432 Cholestadienes ...
Cholestadienes D4.808.247.222.222 D4.210.500.247.222.222 Cholestadienols D4.808.247.222.222.347 D4.210.500.247.222.222.347 ...
Cholestadienes [D04.210.500.247.222.222] * Cholestenones [D04.210.500.247.222.265] * Cholesterol [D04.210.500.247.222.284] ...
Cholestadienes Cholestadienols Cholestanes Cholestanetriol 26-Monooxygenase Cholestanol Cholestanols Cholestanones Cholestasis ...

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