A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.
A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.
A subtype of cholecystokinin receptor found primarily in the CENTRAL NERVOUS SYSTEM and the GASTRIC MUCOSA. It may play a role as a neuromodulator of dopaminergic neurotransmission the regulation of GASTRIC ACID secretion from GASTRIC PARIETAL CELLS.
An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.
A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.
A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.
A process whereby bile is delivered from the gallbladder into the duodenum. The emptying is caused by both contraction of the gallbladder and relaxation of the sphincter mechanism at the choledochal terminus.
A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.
Full gratification of a need or desire followed by a state of relative insensitivity to that particular need or desire.
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.
A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Behavioral response associated with the achieving of gratification.
HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.
The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
The consumption of edible substances.
The evacuation of food from the stomach into the duodenum.
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Radiography of the gallbladder after ingestion of a contrast medium.
A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.
A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)
A surgical procedure which diverts pancreatobiliary secretions via the duodenum and the jejunum into the colon, the remaining small intestine being anastomosed to the stomach after antrectomy. The procedure produces less diarrhea than does jejunoileal bypass.
The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
Derived proteins or mixtures of cleavage products produced by the partial hydrolysis of a native protein either by an acid or by an enzyme. Peptones are readily soluble in water, and are not precipitable by heat, by alkalis, or by saturation with ammonium sulfate. (Dorland, 28th ed)
Compounds that include the amino-N-phenylamide structure.
The motor activity of the GASTROINTESTINAL TRACT.
Physiologic mechanisms which regulate or control the appetite and food intake.
Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
N-(1-Oxobutyl)-cyclic 3',5'-(hydrogen phosphate)-2'-butanoate guanosine. A derivative of cyclic GMP. It has a higher resistance to extracellular and intracellular phosphodiesterase than cyclic GMP.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH.
The time frame after a meal or FOOD INTAKE.
A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.
The inactive proenzyme of trypsin secreted by the pancreas, activated in the duodenum via cleavage by enteropeptidase. (Stedman, 25th ed)
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.
The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.
Agents that are used to suppress appetite.
The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin. (1/1430)

1. Proliferative effects of CCK peptides have been examined in rat anterior pituitary GH3 cells, which express CCK2 receptors. 2. CCK-8s, gastrin(1-17) and its glycine-extended precursor G(1-17)-Gly, previously reported to cause proliferation via putative novel sites on AR4-2J and Swiss 3T3 cells, elicited significant dose dependent increases of similar magnitude in [3H]thymidine incorporation over 3 days in serum-free medium of 39 +/- 10% (P < 0.01, n = 20), 37 +/- 8% (P < 0.01, n = 27) and 41 +/- 6% (P < 0.01, n = 36) respectively. 3. CCK-8s and gastrin potentially stimulated mitogenesis (EC50 values 0.12 nM and 3.0 nM respectively), whilst G-Gly displayed similar efficacy but markedly lower potency. L-365,260 consistently blocked each peptide. The CCK2 receptor affinity of G-Gly in GH3 cells was 1.09 microM (1.01;1.17, n = 6) and 5.53 microM (3.71;5.99, n = 4) in guinea-pig cortex. 4. 1 microM G-Gly weakly stimulated Ca2+ increase, eliciting a 104 +/- 21% increase over basal Ca2+ levels, and was blocked by 1 microM L-365,260 whilst CCK-8s (100 nM) produced a much larger Ca2+ response (331 +/- 14%). 5. Insulin dose dependently enhanced proliferative effects of CCK-8s with a maximal leftwards shift of the CCK-8s curve at 100 ng ml(-1) (17 nM) (EC50 decreased 500 fold, from 0.1 nM to 0.2 pM; P < 0.0001). 10 microg ml(-1) insulin was supramaximal reducing the EC50 to 5 pM (P = 0.027) whilst 1 ng ml(-1) insulin was ineffective. Insulin weakly displaced [125I]BHCCK binding to GH3 CCK2 receptors (IC50 3.6 microM). 6. Results are consistent with mediation of G-Gly effects via CCK2 receptors in GH3 cells and reinforce the role of CCK2 receptors in control of cell growth. Effects of insulin in enhancing CCK proliferative potency may suggest that CCK2 and insulin receptors converge on common intracellular targets and indicates that mitogenic stimuli are influenced by the combination of extracellular factors present.  (+info)

Diazepam-binding inhibitor33-50 elicits Ca2+ oscillation and CCK secretion in STC-1 cells via L-type Ca2+ channels. (2/1430)

We recently isolated and characterized 86-amino acid CCK-releasing peptide from porcine intestinal mucosa. The sequence of this peptide is identical to that of porcine diazepam-binding inhibitor (DBI). Intraduodenal administration of DBI stimulates the CCK release and elicits pancreatic secretion in rats. In this study we utilized a murine tumor cell line (STC-1 cells) that contains CCK to examine if DBI directly acts on these cells to stimulate CCK release. We investigated the cellular mechanisms responsible for this action. We showed that DBI33-50, a biologically active fragment of DBI1-86, significantly stimulated CCK secretion in STC-1 cells. This action was abolished by Ca2+-free medium. The mean basal intracellular Ca2+ concentration ([Ca2+]i) was 52 nM in fura 2-loaded STC-1 cells. DBI33-50 (1-1,000 nM) elicited Ca2+ oscillations; DBI33-50 (10 nM) increased the oscillation frequency to 5 cycles/10 min and elicited a net [Ca2+]i increase (peak - basal) to 157 nM. In contrast, bombesin and forskolin caused an initial transient [Ca2+]i followed by a small sustained [Ca2+]i plateau. Withdrawal of extracellular Ca2+ abolished Ca2+ oscillations stimulated by DBI33-50. L-type Ca2+ channel blockers nifedipine and diltiazem (3-10 microM) markedly attenuated DBI-stimulated Ca2+ oscillations. In other cell types L-type Ca2+ channels are activated by cAMP-protein kinase A. DBI33-50 failed to stimulate cAMP formation in STC-1 cells. Similarly, DBI33-50 had no effect on myo-inositol 1,4, 5-trisphosphate concentration ([IP3]), whereas bombesin caused an eightfold increase in [IP3] over basal. In addition, inhibitors of phospholipase C (U-73122), phospholipase A2 (ONO-RS-082), and protein tyrosine kinase (genistein) did not alter the Ca2+ oscillations elicited by DBI33-50. It appears that DBI33-50 acts directly on STC-1 cells to elicit Ca2+ oscillations via the voltage-dependent L-type Ca2+ channels, resulting in the secretion of CCK. Mediation of this action is by intracellular mechanisms independent of the traditional signal transduction pathways, including phospholipase C, phospholipase A2, protein tyrosine kinase, and cAMP systems.  (+info)

The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects. (3/1430)

AIMS: Somatostatin analogues (e.g. vapreotide) are used for treatment of acromegaly, endocrine tumours and variceal bleeding. The pharmacodynamic effects of vapreotide have, however, not been documented in the gastrointestinal tract. The aim of this study was to investigate the effects of continuous vapreotide administration on gastric acidity, gallbladder contraction and hormone release. METHODS: Ten healthy males participated in this randomised, placebo-controlled, double-blind, crossover trial. A constant vapreotide (or placebo) infusion (1.5 mg day(-1) s.c.) was given for 7 days with a portable pump. Intragastric pH was monitored on days 2 and 7. Gallbladder volume was sonographically assessed and the maximal ejection fraction was calculated. In addition basal and postprandial plasma levels of gastrin and cholecystokinin (CCK) were measured. RESULTS: After an initial increase in the median 24 h intragastric pH to a value of 2.6 on day 2, vapreotide's effect on pH decreased: (day 7: median pH=1.9; respective placebo values were 1.7 and 1.5). On the same days with vapreotide treatment, gallbladder contraction and plasma levels of CCK were reduced; maximal ejection fractions after meal stimulation were 18% and 20% (respective placebo values were 57% and 62%). Plasma gastrin levels were not changed with vapreotide treatment. CONCLUSIONS: The short lasting effect of vapreotide on intragastric acidity suggests a down-regulation of somatostatin receptors during treatment. The lack of effect on gastrin indicates that the effects on gastric pH are not mediated by gastrin. Constant vapreotide infusion (but not placebo) reduced gallbladder contraction suggesting a long-lasting effect on biliary function.  (+info)

Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini. (4/1430)

We evaluated intracellular pathways responsible for the activation of the small GTP-binding protein Rho p21 in rat pancreatic acini. Intact acini were incubated with or without CCK and carbachol, and Triton X-100-soluble and crude microsomes were used for Western immunoblotting. When a RhoA-specific antibody was used, a single band at the location of 21 kDa was detected. CCK (10 pM-10 nM) and carbachol (0.1-100 microM) dose dependently increased the amount of immunodetectable RhoA with a peak increase occurring at 3 min. High-affinity CCK-A-receptor agonists JMV-180 and CCK-OPE (1-1,000 nM) did not increase the intensities of the RhoA band, suggesting that stimulation of RhoA is mediated by the low-affinity CCK-A receptor. Although an increase in RhoA did not require the presence of extracellular Ca2+, the intracellular Ca2+ chelator 1, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-AM abolished the appearance of the RhoA band in response to CCK and carbachol. The Gq protein inhibitor G protein antagonist-2A (10 microM) and the phospholipase C (PLC) inhibitor U-73122 (10 microM) markedly reduced RhoA bands in response to CCK. The protein kinase C (PKC) activator phorbol ester (10-1,000 nM) dose dependently increased the intensities of the RhoA band, which were inhibited by the PKC inhibitor K-252a (1 microM). The pp60(c-src) inhibitor herbimycin A (6 microM) inhibited the RhoA band in response to CCK, whereas the calmodulin inhibitor W-7 (100 microM) and the phosphoinositide 3-kinase inhibitor wortmannin (6 microM) had no effect. RhoA was immunoprecipitated with Src, suggesting association of RhoA with Src. Increases in mass of this complex were observed with CCK stimulation. In permeabilized acini, the Rho inhibitor Clostridium botulinum C3 exoenzyme dose dependently inhibited amylase secretion evoked by a Ca2+ concentration with an IC50 of C3 exoenzyme at 1 ng/ml. We concluded that the small GTP-binding protein RhoA p21 exists in pancreatic acini and appears to be involved in the mediation of pancreatic enzyme secretion evoked by CCK and carbachol. RhoA pathways are involved in the activation of PKC and Src cascades via Gq protein and PLC.  (+info)

Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. (5/1430)

The gut peptide CCK is a nutrient-related signal important to the control of food intake. In the present studies, we observed that a single intraperitoneal injection of CCK (1-2 microgram/kg) given 2-3 h after intracerebroventricular leptin (2-5 microgram) reduced body weight and chow intake over the ensuing 48 h more than did leptin alone. CCK alone had no effect on either 48-h chow intake or body weight but significantly reduced feeding during a 30-min sucrose test. However, reduction of 30-min sucrose intake by CCK was not enhanced by prior intracerebroventricular leptin. The present data suggest that CCK can contribute to the regulation of body weight when central leptin levels are elevated.  (+info)

Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator. (6/1430)

Many important enzyme activities are regulated by Ca2+-dependent interactions with calmodulin (CaM). Some of the most important targets for CaM action are in the nucleus, and Ca2+-dependent CaM translocation into this organelle has been reported. Hormone-evoked cytosolic Ca2+ signals occur physiologically as oscillations, but, so far, oscillations in CaM concentration have not been described. We loaded fluorescent-labeled CaM into pancreatic acinar cells and monitored the fluorescence in various regions by confocal microscopy. Sustained high concentrations of the hormone cholecystokinin or the neurotransmitter acetylcholine evoked a transient movement of cytosolic CaM from the basal nonnuclear area into the secretory granule region and, thereafter, a more substantial and prolonged translocation of CaM into the nucleoplasm. About 50% of the CaM that bound Ca2+ translocated. At a lower hormone concentration, evoking Ca2+ oscillations, regular spikes of increased CaM concentration were seen in the secretory granule region with mirror image spikes of decreased CaM concentration in the basal nonnuclear region. The nucleus was able to integrate the Ca2+ spike-evoked pulses of CaM translocation into a sustained elevation of the nucleoplasmic concentration of this protein.  (+info)

Supraspinal neurotensin-induced antianalgesia in mice is mediated by spinal cholecystokinin. (7/1430)

Intracerebral injection of neurotensin into specific brain loci in rats produces hyperalgesia due to the release of cholecystokinin (CCK) in the spinal cord. The present purpose was to show in another species that neurotensin can antagonize the antinociceptive action of morphine through the spinal CCK mechanism in mice. Neurotensin given intracerebroventricularly (i.c.v.) at doses higher than 100 ng produced antinociception in the tail flick test. However, at lower doses between 1 pg to 25 ng, neurotensin antagonized the antinociceptive action of morphine given intrathecally (i.t.), thus demonstrating the antianalgesic activity of neurotensin. The rightward shift in the morphine dose-response curve produced by i.c.v. neurotensin was eliminated by an i.t. pretreatment with CCK8 antibody (5 microl of antiserum solution diluted 1:1000). I.t. administration of lorglumide, a CCK(A)-receptor antagonist (10-1000 ng), and PD135,158, a CCK(B)-receptor antagonist (250-500 ng), also eliminated the antianalgesic action of neurotensin. Thus, the mechanism of the antianalgesic action of neurotensin given i.c.v. involved spinal CCK. This mode of action is similar to that for the antianalgesic action of supraspinal pentobarbital which also involves spinal CCK.  (+info)

Effects of alverine citrate on cat intestinal mechanoreceptor responses to chemical and mechanical stimuli. (8/1430)

BACKGROUND: Alverine citrate is commonly used in the treatment of painful affections of the colon. AIM: To determine whether alverine citrate acts on the vagal sensory endings. METHODS: Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion of anaesthetized cats using extracellular glass microelectrodes, and the patterns of response to chemical and mechanical stimuli applied to identified vagal intestinal mechanoreceptors were studied. RESULTS: The intestinal mechanoreceptors located at the endings of type C vagal fibres responded mainly to mechanical stimuli (distension and contraction), but also responded to chemical substances (cholecystokinin and substance P). The most conspicuous effect of alverine (2 mg/kg) was that it significantly inhibited the pattern of vagal activity produced in response to either cholecystokinin (5-10 microg/kg), substance P (5-10 microg/kg) or phenylbiguanide (5-10 microg/kg), a 5-HT3 receptor agonist. On the other hand, the unitary vagal response to the mechanical distension was slightly enhanced by alverine, as was any spontaneous activity present. CONCLUSIONS: Based on the present data, alverine citrate can be said to decrease the sensitivity of the intestinal mechanoreceptors, which is consistent with its previously established anti-spasmodic effects.  (+info)

TY - JOUR. T1 - Endogenous cholecystokinin is not a major regulator of food intake in the chicken. AU - Choi, Y. H.. AU - Furuse, M.. AU - Satoh, S.. AU - Okumura, J.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - This study investigated whether or not endogenous cholecystokinin exerts satiety effects in chickens. After several doses (0, 1, 2 and 4 μg·kg body weight-1) of intravenous injection of caerulein, the bile flow was increased in a dose-dependent fashion. However, the pharmacological level of caerulein failed to suppress the food intake of chickens. Two potent stimulators of endogenous cholecystokinin, i.e., soybean trypsin inhibitor and phenylalanine were administered to chickens before feeding and food intake was determined over 2 h. The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken pancreatic acini stimulated by caerulein. However, devazepide did not ...
Secretory and electrophysiological properties of STC-1 cells, a cholecystokinin-secreting cell line, were examined with a radioimmunoassay and patch-clamp recording techniques. Stimulation of cholecystokinin secretion was seen after exposure to agents anticipated to increase the level of intracellular calcium, including thapsigargin (8 muM), bombesin (50 nM), potassium-induced depolarization (50 mM), or after blockade of potassium channels with barium chloride (2 mM). The secretory effects of these agents were blocked by pretreatment with the calcium channel blocker diltiazem (1 muM).
Aim An experimental study was performed to evaluate the effect of whole gut irrigation (WGI) solutions on contractile responses of the gallbladder and ileum and also on tissue cholecystokinin (CCK) levels. ...
TY - JOUR. T1 - Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. AU - de Lartigue, Guillaume. AU - Barbier de la Serre, Claire. AU - Espero, Elvis. AU - Lee, Jennifer. AU - Raybould, Helen E. PY - 2012/3/7. Y1 - 2012/3/7. N2 - Background and Aims: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby increasing their sensitivity to CCK. In response to a chronic ingestion of a high fat diet, VAN develop leptin resistance and the satiating effects of CCK are reduced. We tested the hypothesis that leptin resistance in VAN is responsible for reducing CCK signaling and satiation. Results: Lean Zucker rats sensitive to leptin signaling, significantly reduced their food intake following administration of CCK8S ...
Sex hormones including estrogens affect brain areas involved in mood and cognition in addition to directly controlling reproduction and reproductive behavior. We studied the effect of pregnancy and puerperium on the concentrations of cholecystokinin (CCK), neuropeptide Y (NPY), substance P (SP) and galanin in tissue extracts from the rat striatum, frontal cortex and the hippocampal formation by means of radioimmunoassay. The most profound effects were found in the frontal cortex. Thus, cholecystokinin-like immunoreactivity (CCK-LI) was increased by 40 % during late pregnancy (p , 0.01) compared to estrous whereas SP-LI and galanin-LI decreased 25 % and 10 %, respectively. Postpartum, CCKLI decreased by 26% compared to pregnancy (p , 0.05) whereas SP-LI and galanin-LI were increased to a level above estrous (SP, P , 0.01; galanin, P , 0.05). No significant effect was observed in NPY-LI in this area. In the striatum during late pregnancy the concentrations of cholecystokinin-LI increased by 29 % ...
Definition of cholecystokinin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is cholecystokinin? Meaning of cholecystokinin as a finance term. What does cholecystokinin mean in finance?
1. A scheme of synthesis was developped for cholecystokinin (CCK 26-33, using solid-phase methodology and successfully applied to the synthesis of its C- and N-terminal fragments. 2. Using CCK 30-33 as model, it was found that deprotection of the ?-phenacyl ester, with a 1 M solution of sodium thiophenoxide in DMF, leads to the formation of an aminosuccylnyl peptide, prior to ammonolysis. 3. Selenophenol reagent successfully removes the ?-phenacyl ester on protected CCK 32-33 and on protected CCK 30-33 polymer prior to ammonolytic cleavage of peptides from the resin. 4. Treatment of Boc-Asp(?-OPac)-Tyr(0-2,4-Dnp)-Met-Gly-Trp(Nin-For)-Met-Asp(?-OPac)-Phe-polymer with a 1 M solution of selenophenol in DMF, leads to irreversible rearrangement of the 0-2,4-dinitrophenyl ether. 5. Undesirable side-reactions can be avoided by sequential deprotections and cleavage. The 0-2,4-dinitrophenyl ether is removed by thiolysis following by selenolysis of the ?-phenacyl esters. Cleavage of the peptide from the ...
TY - JOUR. T1 - Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents. AU - Gulyás, A. I.. AU - Görcs, T.. AU - Freund, T.. PY - 1990. Y1 - 1990. N2 - The termination pattern of septohippocampal axons visualized by anterograde transport of Phaseolus vulgaris leucoagglutinin was studied in the hippocampal formation in the rat, with special reference to the innervation of neurons immunoreactive for the neuroactive peptides cholecystokinin, somatostatin or vasoactive intestinal polypeptide. The type I, GABAergic, septohippocampal afferents were shown to terminate on neurons immunoreactive for each of the three peptides. The cholecystokinin-like immunoreactive neurons in all regions, and the somatostatin-immunoreactive cells in stratum oriens of CA1 region were the most preferred targets. Cholecystokinin-immunoreactive cells, especially those in the granule cell layer of the dentate gyrus, were often seen to be contacted by type II (presumed ...
Cholecystokinin A Receptor: A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.
Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) that functions at single-neuron resolution to suppress male sexual behavior in Drosophila. We found that Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for male sexual behaviors, and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spontaneous walking. We further found that the DSK-2 peptide functions through its receptor CCKLR-17D3 to suppress sexual behaviors in flies. Such a neuropeptide circuit largely overlaps with the fruitless-expressing neural circuit that governs most aspects of male sexual behaviors. Thus DSK/CCKLR signaling in the sex ...
Patients with severe obsessive compulsive disorder, depression or bulimia patients were all found to have abnormally low serotonin levels.[14] Neurotransmitters such as serotonin, dopamine and norepinephrine are secreted by the intestines and central nervous system during digestion.[15] Researchers have also found low cholecystokinin levels in bulimics. Cholecystokinin is a hormone that causes one to feel full and decreases eating. Low levels of this hormone are likely to cause a lack of satiative feedback when eating, which can lead to overeating. Another explanation researchers found for overeating is abnormalities in the neuromodulator peptides, neuropeptide Y and peptide YY. Both of these peptides increase eating and work with another peptide called leptin. Leptin is released by fat cells and is known to decrease eating. Research found the majority of people who overate produced normal amounts of leptin but they might have complications with the blood-brain barrier preventing an optimal ...
In the course of our study on cholecystokinin (CCK) a series of Boc-CCK-7 was synthesized. Their carboxyterminal part was modified by phenylalanine derivatives containing 2 or 4 and 2,6 or 2,4,6 methylated aromatic side-chain. During the synthesis, the racemic phenylalanine derivatives were used and peptides containing either L- or D- methylated phenylalanine were separated using a preparative HPLC. Gall bladder contraction, anorectic, sedative and analgetic bioassays of these analogues revealed that all of them behaved as CCK-8 agonists. While the analogues containing L-form of the methylated phenylalanines had almost the same potency (80% - 130%) in comparison to CCK-8, the presence of the D-form decreased the biological activity of corresponding analogues to 8 - 62% of the CCK-8 potency. These results are in agreement with the suggestion that phenylalanine residue in C-terminus takes part in biological activity transduction only.. ...
Pérez de la Mora, M., Hernández-Gómez, A. M., Arizmendi-García, Y., Jacobsen, K. X., Lara-García, D., Flores-Gracia, C., Crespo-Ramírez, M., Gallegos-Cari, A., Nuche-Bricaire, A. and Fuxe, K. (2007), Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release. European Journal of Neuroscience, 26: 3614-3630. doi: 10.1111/j.1460-9568.2007.05963.x ...
EVIDENCE THAT CHOLECYSTOKININ INDUCES IMMEDIATE-EARLY GENE-EXPRESSION IN THE BRAIN-STEM, HYPOTHALAMUS AND AMYGDALA OF THE RAT BY A CCKA RECEPTOR MECHANISM Journal Article ...
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C-Terminal cholecystokinin (CCK)-peptides of increasing chain lengths were all linked at their N-termini to the single surface-exposed cysteine residue 107 of yeast iso-I-cytochrome c by the maleimide/thiol reaction. The resulting CCK/cytochrome I: I conjugates with the haptenic peptides in the identical protein environment were used to immunize outbred guinea pigs in order to assess the critical size of CCK peptides required for the expression of a CCKspecific epitope and the induction of antibodies not crossreacting with the homologous gastrin sequence. By using standard ELISA techniques with polystyrene-adsorbed antigen to evaluate the specificity of the antisera, none of the conjugates were found to induce anti-CCK antisera not crossreacting with gastrin. However, when the biotinyl-CCK-antigen was immobilized by polystyrene-adsorbed avidin, i.e. via a procedure which assures maximum accessibility of the bound antigen, we were able to demonstrate that with CCK-12 and particularly CCK-B, ...
The in vivo release of cholecystokinin (CCK)-like material (CCKLM) was measured in the frontal cortex of freely moving rats using the microdialysis technique combined with a sensitive radioimmunoassay. Local perfusion of K+ (100 mM)-enriched artificial CSF resulted in a 10-fold increase in CCKLM outflow, as compared with that occurring under basal resting (K+ = 3.0 mM) conditions, and this effect could be completely prevented by removal of Ca2+ in the perfusing fluid. Chromatographic analyses demonstrated that CCK-8S contributed to 70% of CCKLM. Stressful stimuli such as a 2-min exposure to diethyl ether and a 30-min restraint produced a marked but transient increase in cortical CCKLM release. In addition, anxiety-like behavior induced by the systemic administration of yohimbine (5 mg/kg i.p.) was associated with a long-lasting enhancement in the peptide outflow. Pretreatment with the potent anxiolytic drug diazepam (5 mg/kg i.p., 5 min before each condition), which exerted no effect on its own,
Since the neuropeptide cholecystokinin (CCK) plays a role in the modulation of opiate-induced analgesia, the morphine-mediated release of CCK in the spinal cord of rats was compared with in vivo microdialysis in normals and different pain models ...
Principal Investigator:KONO Akira, Project Period (FY):1998 - 1999, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Gastroenterology
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Cholecystokinin and related peptides are involved in the control of intestinal motility and cholecystokinin receptor ligands might represent new pharmacological tools for the treatment of symptoms associated with functional bowel disorders. However, the respective roles played by cholecystokinin receptor subtypes and the mechanisms underlying these regulatory actions remain undetermined. This study was designed to examine the influence of cholecystokinin receptor subtypes on the motor activity of guinea-pig distal colon. The effects of drugs acting on CCK1 and CCK2 receptors were assessed in vitro on the contractile activity of longitudinal smooth muscle, both under basal conditions and in the presence of transmural electrical stimulation or KCl-induced contractions. The application of cholecystokinin octapeptide sulphate (cholecystokinin-8S) to colonic preparations induced concentration-dependent contractions which were prevented by devazepide (CCK1 receptor antagonist), enhanced by GV150013 ...
Looking for online definition of cholecystokinin test in the Medical Dictionary? cholecystokinin test explanation free. What is cholecystokinin test? Meaning of cholecystokinin test medical term. What does cholecystokinin test mean?
TY - JOUR. T1 - Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner. AU - Gates, L. K.. AU - Ulrich, C. D.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - The cholecystokinin (CCK) receptor on the rat pancreatic acinar cell is a guanine nucleotide-binding protein (G protein)-coupled receptor, which was recently demonstrated to be phosphorylated in response to agonist stimulation (Klueppelberg et al., J. Biol. Chem. 266: 17744-17746, 1991). In this work, we establish that this receptor is phosphorylated in response to a variety of homologous and heterologous secretagogues and that these phosphorylation events represent action by more than one protein kinase. One subgroup of kinases includes one or more isotype of protein kinase C (PKC), and is capable of playing a role in homologous and heterologous desensitization. A second subgroup of kinases that acts on the CCK receptor was defined by its resistance to 10 μM staurosporine, which was ...
Intraduodenal infusion of ricinoleic acid and iv bolus injection of the C-terminal octapeptide of cholecystokinin produce markedly similar alterations in the digestive contractile patterns of the GI tract of the unanesthetized dog. The brief, initial stimulation of contractile activity in the proximal small intestine following both procedures is mediated through a cholinergic mechanism. The stimulatory response is followed by an inhibition of digestive contractile activity of unknown origin. These observations suggest that possibility that the GI hormone, cholecystokinin, may mediate the intestinal motor response evoked by infusion of ricinoleic acid directly into the proximal small intestine.
The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. Evoked tritium outflow from slices of cat caudate nucleus was Ca2+ dependent and abolished by tetrodotoxin, suggesting that it reflects action potential-induced [3H]dopamine release. In the presence of bovine serum albumin and bacitracin, the sulfated but not the unsulfated form of CCK-8 inhibited both basal and electrically evoked tritium outflow from slices of cat caudate nucleus at very low concentrations. CCK-8 sulfate was efficient in causing this effect in concentrations down to 10(-14) M, and the maximum effect was obtained with 10(-11) M. In contrast, without bovine serum albumin and bacitracin, no inhibitory effect of CCK-8 ...
TY - JOUR. T1 - A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. AU - Lutz, M. P.. AU - Sutor, S. L.. AU - Abraham, R. T.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Cholecystokinin (CCK) is a gastrointestinal hormone that acts through a G protein-coupled receptor to stimulate pancreatic enzyme secretion. In this work, we demonstrate that CCK stimulation of dispersed pancreatic acini results in increased tyrosine phosphorylation of several cellular proteins. This is mediated via a calcium-dependent pathway, also activated by a phenethyl ester analogue of CCK and calcium ionophores, and by a protein kinase C-dependent cascade, also activated by the phorbol ester 12-O- tetradecanoylphorbol-13-acetate. All demonstrable stimulated tyrosine phosphorylation events were inhibited by genistein, with different subsets of proteins affected by staurosporine and H-7. The importance of tyrosine phosphorylation events in ...
A combination of autoradiographical techniques and computerized image analysis has been used to study the distribution and density of cholecystokinin receptors in the paraventricular and supraoptic nuclei of animals in which the magnocellular-posterior pituitary axis is activated, namely, in salt-lo …
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TY - JOUR. T1 - Cholecystokinin secretagogue-induced gastroprotection. T2 - Role of nitric oxide and blood flow. AU - West, Sonlee D.. AU - Helmer, Kenneth S.. AU - Chang, Lily K.. AU - Cui, Yan. AU - Greeley, George H.. AU - Mercer, David W.. PY - 2003/3/1. Y1 - 2003/3/1. N2 - This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition (nG-nitro-L-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal ...
We have previously demonstrated [M. Campos-Toimil, T. Bagrij, J.M. Edwardson, P. Thomas, Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca2+ entry, Curr. Biol. 12 (2002) 211-215] that in rat pancreatic acinar cells, Gd3+-sensitive Ca2+ entry is instrumental in governing which second messenger pathways control secretory activity. However, in those studies, we were unable to demonstrate a significant increase in cytoplasmic [Ca2+] during agonist application as a result of this entry pathway. In the present study, we combined pharmacology with ratiometric imaging of fura-2 fluorescence to resolve this issue. We found that 2 μM Gd3+ significantly inhibits store-mediated Ca2+ entry. Furthermore, both the protonophore, CCCP (5 μM) and the mitochondrial Ca2+-uptake blocker, RU360 (10 μM), led to an enhancement of the plateau phase of the biphasic Ca2+ response induced by acetylcholine (1 μM). This enhancement was ...
Cholecystokinin tetrapeptide (CCK-4, also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.
SIGNIFICANCE OF OCTAPEPTIDE CHOLECYSTOKININ IN DEVELOPMENT OF ODDIS SPHINCTER DYSFUNCTION OF INORGANIC ETIOLOGY AFTER CHOLECYSTECTOMY IN PATIENTS OPERATED FOR CALCULOUS CHOLECYSTITIS
AequoScreen® Double Transfected Cell Lines: Cholecystokinin, CCKA subtype. Human Recombinant, in 1321N1 host cell. Two vials of cryopreserved cells are shipped per order. A detailed technical dossier includes sequence, culture conditions and pharmacological properties of the recombinant receptor. All cell lines are tested for the absence of mycoplasma. Terms and conditions apply. Some products are not available in some countries. Please inquire at your local sales office for more information.. Features:. ...
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This work unlined the importance of fat in generating dyspeptic symptoms by demonstrating how duodenal infusions of fat could sensitise the stomach to distension and to motion sickness. These effects could be treated by drugs that acted on cholecystokinin, opiate and serotonin receptors ...
Context: Cholecystokinin A receptor (polymorphism is stabilized and it is more consistently connected with schizophrenia within an Eastern Indian sub-population. at 95% =1.04C2.20). Bottom line: polymorphism from the gene is normally a well balanced polymorphism inside our research people. Furthermore, the C allele is normally significantly more loaded in schizophrenia sufferers imparting them a larger risk of advancement of problems like auditory hallucination. receptor (and which serves as a mediator of DA activity and escalates the discharge of DA even though performs a converse actions. Any hyper or alteration activity of results in the boosts in DA along with a consequent predisposition for schizophrenia.[10] The protein is one of the seven transmembrane receptor superfamily associated with G-protein coupled sign transduction pathway. The human gene contains five extends and exons over 21.8 kb across the 4p15 chromosome region.[11] The top features of the promoter region add a transcription ...
See also agnosia cialis professional. Situations are animals, birds, insects, heights, the icd-11 criteria for the fundamental defects in a mental state, are evidence of gut hormone cholecystokinin (cck) whereas acid in 1942 by harvard university researchers call it. Tolerance is rare. The prolonged the time of adnexectomy is worthy of specific comment, it joins the femoral bruit. This large thyroidal pool of candidate statements about an hour without a known case, the same intensity which is perpendicular to the right, and one pair of cranial nerves involved and their likelihood ratios quoted in the american hemorrhage: Prospective, modern academy of allergy, particularly of the child-bearing age excessive vaginal bleeding. Clobazam is claimed to achieve hemostatic control, as in equivalent therapeutic doses (8-30 mg orally), amphetamine produces weakness, fatiguability, twitching and mental experience. Sleep: 5-ht controls sleep-wakefulness cycle; depletion of catecholamines and 8-ht which ...
Chung et al. studied drivers of obesity-associated pancreatic ductal adenocarcinoma in a leptin-deficient mouse model and identified the hormone cholecystokinin, upregulated in islet beta cells in the context of obesity, to be promoting pancreatic tumorigenesis.
L-365260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively).
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Expression of Two Different Cholecystokinin Receptors in Xenopus Oocytes Injected with mRNA from Rabbit Pancreas and Rat Hippocampus (1996 ...
Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin.
Cholesterol absorption plays a key role in cholesterol homeostasis and understanding the lumenal events that play key roles in absorption remain poorly understood. The aims of the present study are fourfold: 1) To determine whether previously observed effects on cholesterol absorption during bile acid feeding are related to changes in pool size and intestinal transit or meal stimulated gall bladder emptying or plasma cholecystokinin levels. 2) To determine the effect of dietary sphingomyelin on cholesterol absorption, micellar solubilization and synthesis in normal adults and to assess the effects of intralumenal cholesterol solubilization, absorption and synthesis in adults with heterozygous mdr 3 deficiency (a defect leading to low biliary phospholipid content). 3) To determine the mechanism of action of a non-ionic detergent, Pluronic F-68, by evaluating its effect on cholesterol solubilization and distribution between micelles and vesicles, on cholesterol absorption and synthesis. 4) To ...
Cholesterol absorption plays a key role in cholesterol homeostasis and understanding the lumenal events that play key roles in absorption remain poorly understood. The aims of the present study are fourfold: 1) To determine whether previously observed effects on cholesterol absorption during bile acid feeding are related to changes in pool size and intestinal transit or meal stimulated gall bladder emptying or plasma cholecystokinin levels. 2) To determine the effect of dietary sphingomyelin on cholesterol absorption, micellar solubilization and synthesis in normal adults and to assess the effects of intralumenal cholesterol solubilization, absorption and synthesis in adults with heterozygous mdr 3 deficiency (a defect leading to low biliary phospholipid content). 3) To determine the mechanism of action of a non-ionic detergent, Pluronic F-68, by evaluating its effect on cholesterol solubilization and distribution between micelles and vesicles, on cholesterol absorption and synthesis. 4) To ...
CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. CCK-B expression may correlate parallel to anxiety and depression phenotypes in humans. CCK-B receptors possess a complex regulation of dopamine activity in the brain. CCK-B activation appears to possess a general inhibitory action on dopamine activity in the brain, opposing the dopamine-enhancing effects of CCK-A. However, the effects of CCK-B on dopamine activity vary depending on location.[11] CCK-B antagonism enhances dopamine release in rat striatum.[12] Activation enhances GABA release in rat anterior nucleus accumbens.[13] CCK-B receptors modulate dopamine release, and influence the development of tolerance to opioids.[14] CCK-B activation decreases amphetamine-induced DA release, and contributes to individual variability in response to amphetamine.[15] In rats, CCK-B antagonism prevents the stress-induced reactivation of cocaine-induced conditioned place preference, and ...
1. Coeliac patients are known to have an expanded bile salt pool which recirculates slowly due, at least in part, to impaired gall bladder contractility. We have investigated the possibility that delayed small bowel transit of chyme and bile may also contribute to this sluggish recycling.. 2. Plasma cholylglycine, total bile acids and cholecystokinin concentrations were measured after a lactulose-labelled test meal whose mouth-caecum transit time (M-C TT) was assessed by the breath hydrogen technique.. 3. Overall there were no significant differences in plasma bile acid profiles between seven healthy controls and a group of 25 coeliac patients. However, when subjects were divided according to their M-C TT, the 10 with the slowest transit were found to have significant elevation of fasting levels when compared with the 10 with the fastest transit, fasting total bile acids being 3.4 ± 1.3 versus 0.7 ± 0.6 μmol/l (P , 0.02) and fasting cholylglycine being 0.43 ± 0.17 versus 0.06 ± 0.04 μmol/l ...
This work extends a recent observation that Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of non-insulin-dependent diabetes mellitus, show no expression of the cholecystokinin (CCK)-A receptor gene in the pancreas. The CCK-A receptor is known to be in...
To investigate the electrophysiological properties, synaptic connections, and anatomy of individual parvalbumin-immunoreactive (PV-IR) and cholecystokinin-immunoreactive (CCK-IR) interneurones in CA1, dual intracellular recordings using biocytin-filled microelectrodes in slices of adult rat hippocampus were combined with fluorescence labelling of PV- and CCK-containing cells. Of 36 PV-IR cells, 29 were basket cells, with most of their axonal arbours in the stratum pyramidale (SP). Six were bistratified cells with axons ramifying throughout stratum oriens (SO) and stratum radiatum (SR). One was a putative axo-axonic cell with an axonal arbour confined to half of the SP and a narrow adjacent region of the SO. Of 27 CCK-IR neurones, 13 were basket cells, with most of their axonal arbours in the SP, and included basket cells with somata in the SP (6), SO (3), and SR (2) and at the border between the stratum lacunosum-moleculare (SLM) and the SR (2). In addition, several dendrite-targeting cell ...
We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats. Intraduodenal ad
Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointestinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58. CCK-4 reliably causes severe anxiety symptoms when administered to humans in a dose of as little as 50μg,[1] and is commonly used in scientific research to induce panic attacks for the purpose of testing new anxiolytic drugs.[2][3][4][5] Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a short duration of action,[6] although numerous synthetic analogues with modified properties are known.[7][8][9][10][11][12][13][14][15][16][17] ...
Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood. . ...
In the hippocampal CA1 area, a relatively homogenous population of pyramidal cells is accompanied by a diversity of GABAergic interneurons. Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. A second family of interneurons, expressing cholecystokinin but not parvalbumin, is known to target the same domains of pyramidal cells as do the parvalbumin cells. To test the temporal activity of these independent and parallel GABAergic inputs, we recorded the precise spike timing of identified cholecystokinin interneurons during hippocampal network oscillations in anesthetized rats and determined their molecular expression profiles and synaptic targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing basket and dendrite
high-fiber and gas-producing bile from the gallbladder. Gall bladder surgical interventional endoscopist. It can be detected gallbladder foods with protein using gallbladder means that they will suggests that could be that has characteristic symptom of gallbladder is an internal organs. Gallbladder attack is connected to a natural treatment of Gallbladder means that patients usually join together within a few people. Even in appalling circumstances to ask for the digestive tract, which may also wish to try. The primary function of the hormone cholecystokinin causes the gallbladder stones. Yes and treatment option, its a reminder the liver cells. Trim health benefits of liver the fat contact some complicated gallbladder, gall bladder infection signs can be seen on taking deep breaths. The side effectively removes gallbladder pain after surgery zoloft gallstones may develops with duct or if you are scheduled to accept their gallbladder problems. If the cancer of the best way to ensure that the ...
The liver produces bile which is stored in the gall bladder. It then flows down through the bile duct into the duodenum. It is a green liquid, a mixture of substances not all of which are involved in the digestion. The digestion components are inorganic components of sodium. These salts emulsify lipids by lowering their surface tension causing them to break up into numerous droplets there by increasing their surface area for enzyme action. The secretion of bile is controlled by a hormone CHOLECYSTOKININ, while its production in the liver is controlled by the hormone Secretin. Bile is also rich in sodium bicarbonate, which neutralizes the acid from the stomach. The PH of the small intestines is therefore alkaline, which favors the action of the various enzymes. The hormones secretin also stimulates the pancreas to release pancreatic juice into the duodenum via the pancreatic duct. Pancreatic juice contains three enzymes. ...
1. Adler G: Regulation of human pancreatic secretion. Digestion 58 Suppl 1:39-41,1997. 2. Berg JM, Tymoczko JL, Stryer L: Many enzymes are activated by specific proteolytic cleavage. Biochemistry. 5th edition. New York: W H Freeman, Section 10.5,2002. 3. Bourassa J, Laine J, Kruse ML, Gagnon MC, Calvo E, Morisset J: Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors. Biochem Biophys Res Commun 260:820-828,1999. 4. Chandra R, Liddle RA: Neural and hormonal regulation of pancreatic secretion. Curr Opin Gastroenterol 25:441-446,2009. 5. Dufresne M, Seva C, Fourmy D: Cholecystokinin and gastrin receptors. Physiol Rev 86:805-847,2006. 6. Folsch UR, Winckler K, Wormsley KG: Influence of repeated administration of cholecystokinin and secretin on the pancreas of the rat. Scand J Gastroenterol 13:663-671,1978. 7. Geron E, Schejter ED, Shilo BZ: Assessing the secretory capacity of pancreatic acinar cells. J Vis Exp,2014. 8. Goke B, Printz H, Koop I, ...
The present results strongly suggest that endogenous gastrin--in contrast to CCK--does not regulate pancreatic growth in the mouse. The inhibitory effect of loxiglumide on omeprazole-induced increase in serum gastrin might be explained by recent findings which showed that CCK-A antagonists can stimu …
The accompanying paper (Bignon et al., 1999) on SR146131 describes the compounds effects as a potent and selective agonist at both human and rodent CCK1 receptors in vitro. The present paper evaluated the drugs effects in vivo, and shows clearly that SR146131 can mimic, in a variety of test systems and in several species, a wide range of the effects of sulfated cholecystokinin octapeptide (CCK8S), which have previously been attributed to the stimulation of CCK1 receptors but not those related to the stimulation of CCK2 receptors.. SR146131 inhibited gastric emptying in mice, and also decreased gallbladder volume in this species after administration of low oral doses. SR146131 also reduced food intake in two rodent and one primate species. The compound reduced food intake in fasted rats, and in nonfasted rats in which food intake had been highly stimulated by the administration of NPY(1-36). Food intake was also reduced by oral administration of SR146131 in fasted gerbils, and in marmosets ...
Ishikawa, M.; Ishimori, A., 1974: Symposium on gastrointestinal hormones. A clinical study of regulation of motility of digestive tract by gastrointestinal hormones
The Rationalle the ShapeMedUSA Diet program is as follows:. 1. Eggs. Skip the bagel this morning. Eggs, which are full of protein, will help you feel fuller longer-a lot longer. A multicenter study of 30 overweight or obese women found that those who ate two scrambled eggs (with two slices of toast and a reduced-calorie fruit spread) consumed less for the next 36 hours than women who had a bagel breakfast of equal calories. Other research has shown that protein may also prevent spikes in blood sugar, which can lead to food cravings.. 2. Beans. Youve probably never heard of cholecystokinin, but its one of your best weight-loss pals. This digestive hormone is a natural appetite suppressant. So how do you get more cholecystokinin? One way, report researchers at the University of California at Davis, is by eating beans: A study of eight men found that their levels of the hormone (which may work by keeping food in your stomach longer) were twice as high after a meal containing beans than after a ...
Steve Bloom (London, U.K.) discussed satiety signals, noting that obesity is key to the [insulin resistance] syndrome and that it ultimately is caused by overeating. Childhood obesity is on the rise, with 40% of children expected to be overweight by 2010. He asked, what explains the reduction in hunger after a meal? Bulk in the stomach and nutrients in the circulation appear not to be the cause. There must be specific signals from the gut to the brain, neural and/or hormonal. It appears that, when stimulated, a small area in the proximal gastric fundus, near the esophagus, sends vagal signals mediating satiety. Studies have attempted to replicate gut hormonal signals by infusion, with cholecystokinin (CCK) decreasing food intake but causing pancreatitis and acting as a growth factor for pancreatic acinar cells, which could cause increased pancreatic cancer risk. Ghrelin decreases after meals and may be a negative satiety signal, as its direct effect is to stimulate food intake. Pancreatic ...
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being electrically excitable, enteroendocrine cells are generally thought to communicate indirectly with nerves through hormone secretion and not through direct cell-nerve contact. However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we named neuropod. Here, we determined that neuropods provide a direct connection between enteroendocrine cells and neurons innervating the small intestine and colon. Using cell-specific transgenic mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for neurotransmission, including expression of genes that encode pre-, post-, and transsynaptic proteins. This neuroepithelial circuit was reconstituted in vitro by coculturing single enteroendocrine cells with sensory ...
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being electrically excitable, enteroendocrine cells are generally thought to communicate indirectly with nerves through hormone secretion and not through direct cell-nerve contact. However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we named neuropod. Here, we determined that neuropods provide a direct connection between enteroendocrine cells and neurons innervating the small intestine and colon. Using cell-specific transgenic mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for neurotransmission, including expression of genes that encode pre-, post-, and transsynaptic proteins. This neuroepithelial circuit was reconstituted in vitro by coculturing single enteroendocrine cells with sensory ...
We employed dual probe microdialysis in the nucleus accumbens and ipsilateral ventral pallidum of the halothane anaesthetized rat to investigate the effect of intra-accumbens perfusion with the sulphated octapeptide cholecystokinin (CCK-8S, 10-1000 nM, 60 min) alone and in the presence of the selective CCK1 and CCK2 receptor antagonists L-364,718 (10 and 100 nM) and PD134308 (10 nM), tetrodotoxin (TTX, 1000 nM) and the GABA(A) receptor antagonist bicuculline (1000 nM), on dialysate GABA levels in the ventral pallidum ...
OBJECTIVE: To compare the difference in the gastrointestinal hormone levels of the patients with the history of diabetes and concurrent nephropathy and inv
As previously mentioned, the sphincter of Oddi is tonically closed when there is no intake of food. As soon as the upper gastro intestinal tract begins digestion and especially when fat and amino acids reach the duodenum 30 minutes after a meal, cholecystokinin enters the blood stream from the duodenal mucosa. This would then stimulate the gallbladder to empty its contents, bile, through rhythmical contractions of its wall. The same hormone would also stimulate increased secretions of digestive enzymes from the pancreas. However, effective emptying would not be completed without CCK decreasing the resistance of the sphincter of Oddi and simultaneously releasing bile and digestive enzymes into the duodenum.. ...
3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic membranes. The radioligand recognized a single class of binding sites with a high affinity (Kd = 0.23 nM). The binding of [3H]-(+/-)-L-364,718 was stereospecific in that the more biologically active (-)-enantiomer demonstrated greater potency than the (+)-enantiomer. The rank order of potency of various CCK agonists and antagonists in displacing [3H]-(+/-)-L-364,718 correlated with their ability to displace [125I]CCK-8 and their known pharmacological activities in peripheral tissues. However, the absolute potencies of agonists were greater in displacing [125I]CCK-8 than [3H]-(+/-)-L-364,718. As described for other physiologically relevant receptor systems, the potency for displacement of [3H]-(+/-)-L-364,718 binding by CCK agonists, but not antagonists, was reduced by guanosine 5-(beta, gamma-imido)triphosphate and NaCl and enhanced by MgCl2. ...
Complete information for CCKBR gene (Protein Coding), Cholecystokinin B Receptor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
1997-2006 Healthboard.com. Healthboard.com is a purely informational website, and should not be used as a substitute for professional legal, medical or technical advice. ...
Y , StdInChIKey = , bioavailability = 100% , protein_bound = , metabolism = proteaze plazme , elimination_half-life = 13 minuta , excretion = N/A , pregnancy_AU = , pregnancy_US = , pregnancy_category= , legal_AU = , legal_CA = , legal_UK = , legal_US = , legal_status = , routes_of_administration = IV }} CCK-4 (holecistokininski tetrapeptid, Trp-Met-Asp-Phe-NH2; ili PTK7) je peptidni fragment izveden iz većeg peptidnog hormona holecistokinina. Za razliku od holecistokina koji ima niz uloga u gastrointestinalnom sistemu kao i u centralnom nervnom sistemu, CCK-4 deluje prvenstveno u mozgu kao stimulator anksioznosti. On pokazuje slabe GI efekte, za razliku od CCK-8 ili polipeptida pune dužine, CCK-58. CCK-4 proizvodi jake simptome anksioznosti u malim dozama, kao što je 50 μg,[1] i često se koristi u naučnim istraživanjima za indukovanje paničnih napada s ciljem testiranja novih anksiolitika.[2][3][4][5] Pošto je on peptid, CCK-4 mora biti administriran putem injekcije. U telu se brzo ...
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Wank, SA (Nov 1995). "Cholecystokinin receptors". The American Journal of Physiology. 269 (5 Pt 1): G628-46. doi:10.1152/ajpgi. ... Takai, N; Shida, T; Uchihashi, K; Ueda, Y; Yoshida, Y (Apr 15, 1998). "Cholecystokinin as neurotransmitter and neuromodulator ... such as cholecystokinin) can be used. The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic ...
The sphincter of Oddi is relaxed by the hormone cholecystokinin via vasoactive intestinal peptide. Opiates may cause spasms of ... Liddle, Rodger A. (2003-01-01). "CCK (Cholecystokinin)". Encyclopedia of Endocrine Diseases: 485-489. doi:10.1016/B0-12-475570- ... 4/00260-2. Wiley JW, O'Dorisio TM, Owyang C (June 1988). "Vasoactive intestinal polypeptide mediates cholecystokinin-induced ...
... of proteins is defined by the peptide hormones gastrin and cholecystokinin. Gastrin and cholecystokinin (CCK) are structurally ... Watson S, Arkinstall S (1994). "Cholecystokinin (CCK) and gastrin". The G-protein linked receptor factsbook. London: Academic ... CCK; GAST; Baldwin GS, Patel O, Shulkes A (February 2010). "Evolution of gastrointestinal hormones: the cholecystokinin/gastrin ... The gastrin family (also known as the gastrin/cholecystokinin family) ...
See also Cholecystokinin-mediated satiety. Economic satiation, where increasing the amount of a good reduces the worth of each ...
ISBN 978-981-31446-3-7. Jorpes, Johan Erik; Mutt, Viktor (1973). Secretin, Cholecystokinin, Pancreozymin and Gastrin. Berlin: ...
de Tullio P, Delarge J, Pirotte B (June 1999). "Recent advances in the chemistry of cholecystokinin receptor ligands (agonists ... Berna MJ, Tapia JA, Sancho V, Jensen RT (December 2007). "Progress in developing cholecystokinin (CCK)/gastrin receptor ligands ... de Tullio P, Delarge J, Pirotte B (January 2000). "Therapeutic and chemical developments of cholecystokinin receptor ligands". ... November 1987). "Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists". ...
Gastrin Cholecystokinin (CCK) The Secretin family are peptides that act as local hormones which regulate activity of G-protein ... Jens F. Rehfeld; Lennart Friis-Hansen; Jens P. Goetze; Thomas V. O. Hansen (2007-06-01). "The Biology of Cholecystokinin and ... 2007). "The biology of cholecystokinin and gastrin peptides". Curr Top Med Chem. 2007;7(12):1154-65. 9. Henriksen JH, de ...
Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide hormone ... February 1997). "Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor". Journal of ... Anokhina IP, Proskuriakova TV, Bespalova Z, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). "[Effect of a cholecystokinin ... Bradwejn J (July 1993). "Neurobiological investigations into the role of cholecystokinin in panic disorder". Journal of ...
... is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects ... Wiertelak, EP; Maier, SF; Watkins, LR (8 May 1992). "Cholecystokinin antianalgesia: safety cues abolish morphine analgesia" ( ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
It is the antagonist of cholecystokinin and opposes pancreatic secretion stimulated by cholecystokinin.[3] It may stimulate the ... The excitation of the vagus nerve, the administration of gastrin, secretin or cholecystokinin induce PP secretion. ...
Cholecystokinin. Cholecystokinin (CCK) has most effect on the gall bladder, causing gall bladder contractions, but it also ...
"Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... cholecystokinin A receptors,[47] and catecholamines,[48][49] as well as to ghrelin, leptin, and glucose.[50] Orexinergic ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
Cholecystokinin B receptor. -. PP: Gastrins. Cholecystokinin. CCK. Cholecystokinin receptors. -. PP: Neurohypophyseals. ...
... cholecystokinin, and secretin all inhibit production. The production of gastric acid in the stomach is tightly regulated by ...
... is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; ...
These include serotonin, neurotensin, cholecystokinin, prostaglandin E1, and gastrin. Clinically, the gastrocolic reflex has ... Disturbed motilin and cholecystokinin release in the irritable bowel syndrome in Scand J Gastroenterol, 31:11, pp 1110-4, PMID ...
Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ... Lloyd K, Maxwell V, Chuang C, Wong H, Soll A, Walsh J (1994). "Somatostatin is released in response to cholecystokinin by ...
... steatorrhoea by inhibiting cholecystokinin and secretin, gall stones by inhibiting cholecystokinin which normally induce ... due to inhibition of cholecystokinin release), and achlorhydria (due to inhibition of gastrin release). Somatostatinomas are ...
2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of ... 1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403-9. doi: ...
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... type B gastrin/cholecystokinin receptor binding. • gastrin receptor activity. • cholecystokinin receptor activity. • peptide ... The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein[5] that in humans is encoded by the CCKBR gene.[6] ... "Entrez Gene: CCKBR cholecystokinin B receptor".. *^ Altar CA, Boyar WC (Apr 1989). "Brain CCK-B receptors mediate the ...
Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the US National Library of Medicine Medical Subject ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) ... It is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to gastrin, another ...
CCK(A) receptor; CCK1; CCK-A receptor; CCKA; CCKAR; CCK-AR; Cholecystokinin receptor 1; Cholecystokinin type A receptor; CCK-1 ... CCK(A) receptor; CCK1; CCK-A receptor; CCKA; CCKAR; CCK-AR; Cholecystokinin receptor 1; Cholecystokinin type A receptor; CCK-1 ... Miller L.J. (2018) Cholecystokinin-1 Receptor. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS ... Agonist-regulated phosphorylation of the pancreatic cholecystokinin receptor. J Biol Chem. 1991;266:2403-8.PubMedPubMedCentral ...
Cholecystokinin (CCK), a digestive hormone released with secretin when food from the stomach reaches the first part of the ... small intestine (duodenum). Cholecystokinin and pancreozymin were once considered two separate hormones because two distinct ... human digestive system: Cholecystokinin. Cholecystokinin, a peptide secreted by the I cells in response to the emptying of the ... More About Cholecystokinin. 3 references found in Britannica articles. Assorted References. *digestive system* In human ...
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Cholecystokinin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ... Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805-47. doi:10.1152/physrev ... There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been ...
Cholecystokinin (CCK) coexists with dopamine in a large proportion of the ventral tegmental and substantia nigra neurons in ... Cholecystokinin-dopamine interactions Trends Pharmacol Sci. 1991 Jun;12(6):232-6. doi: 10.1016/0165-6147(91)90558-a. ... Cholecystokinin (CCK) coexists with dopamine in a large proportion of the ventral tegmental and substantia nigra neurons in ...
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745-81. PMID 10581329.. ... Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805-47. doi:10.1152/physrev ... Cholecystokinin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Cholecystokinin. A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central ... All MeSH CategoriesChemicals and Drugs CategoryAmino Acids, Peptides, and ProteinsPeptidesCholecystokininSincalide ... Cholecystokinin may be the mediator of satiety.. Year introduced: PANCREOZYMIN was heading 1963-1976 (Prov 1963-1966), was see ... and Hormone AntagonistsHormonesGastrointestinal HormonesCholecystokininSincalide ...
Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal ... gastrin/cholecystokinin-like peptide and cionin, a neuropeptide from the protochordate Ciona intestinalis belong to the same ...
Cholecystokinin receptor type A (IPR000596). Short name: Cholcy_rcpt_A Overlapping homologous superfamilies *Cholecystokinin A ... Cholecystokinins (CCKs) and gastrins are naturally-occurring peptides that share a common C-terminal sequence, GWMDF; full ...
Compare cholecystokinin ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... cholecystokinin ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ...
Buy our Recombinant Human Cholecystokinin protein. Ab158040 is a full length protein produced in Wheat germ and has been ... Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the ... The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. ...
Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala.. Mascagni F1, ... In the present study, immunohistochemical techniques were used to analyze neurons in the rat ABL that contain cholecystokinin ( ...
Species specificity of cholecystokinin in gut and brain of several mammalian species. E Straus and R S Yalow ... Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the ... The amount of cholecystokinin in the brain is comparable to that found in the gastrointestinal tract, the traditional site for ... The failure to detect intact cholecystokinin in extracts from monkey or dog by using an antiserum developed by immunization ...
Hormone Health Network is here to answer all your questions about what cholecystokinin is and what it does. Learn more at ... What is Cholecystokinin?. Cholecystokinin, otherwise known as CCK or CCK-PZ, is a hormone that was once called pancreozymin ... Individuals who have cholecystokinin levels that are too high suffer no known ill effects. In fact, the lack of cholecystokinin ... How Does cholecystokinin work?. Cholecystokinins most recognized function is its ability to improve digestion. The hormone ...
Browse our Cholecystokinin Antibodies all backed by our Guarantee+. ... anti-Cholecystokinin antibody, anti-CCK antibody, anti-MGC117187 antibody. 3 Results for "cholecystokinin" in Primary ... Cholecystokinin Antibodies. We offer Cholecystokinin Antibodies for use in common research applications: ELISA, ... Choose from our Cholecystokinin polyclonal antibodies and browse our Cholecystokinin monoclonal antibody catalog. ...
cholecystokinin: A hormone produced principally by the small intestine in response to the presence of fats, causing contraction ... It may also increase the level of hormones in the gut (such as cholecystokinin), which is another way to control your appetite ... It may also increase the level of hormones in the gut (such as cholecystokinin), which is another way to control your appetite ... 5 (HealthDay News) -- A gut hormone called cholecystokinin (CCK) plays an important role in the control of blood sugar ...
... an intestinal cholecystokinin (CCK)secreting cell line. Exposure to the amino acid L-phenylalanine increased release of CCK by ... The secretion of cholecystokinin was examined in STC-1 cells, ... The secretion of cholecystokinin was examined in STC-1 cells, ... These results indicate that, in STC-1 cells, L-phenylalanine stimulates release of cholecystokinin via a calcium-dependent ... 1995). PHENYLALANINE-STIMULATED SECRETION OF CHOLECYSTOKININ IS CALCIUM-DEPENDENT. American Journal of Physiology. ...
... ... "Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages," ...
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder ... Cholecystokinin receptor type AAdd BLAST. 436. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder ... sp,O08786,CCKAR_MOUSE Cholecystokinin receptor type A OS=Mus musculus OX=10090 GN=Cckar PE=1 SV=1 ...
... including the Human CCKB Cholecystokinin Receptor Cell Line, to meet your drug discovery needs. ... Human CCKB Cholecystokinin Receptor Cell Line. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the ...
Ausgesuchte Qualitäts-Hersteller für Cholecystokinin Antikörper. Hier bestellen. ... Monoklonale und polyklonale Cholecystokinin Antikörper für viele Methoden. ... cholecystokinin , cholecystokinin-L , Cholecystokinins , cholecystokinin-N , cholecystokinin triacontatriapeptide , prepro- ... Cholecystokinin type 2 , cholecystokinin (clone CCK-CH), preprocholecystokinin , cholecystokinin B , cholecystokinin type 2 ...
Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). ... Pig Brain contains cholecystokinin octapeptide and several cholecystokinin desoctapeptides, Proc. Natl. Acad. Sci. USA, 80: ... Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). ... J.P. Christphe, E.K. Frandsen, T.P. Conlon, G. Krishna and J.D. Gardner, Action of cholecystokinin, cholinergic agents and A- ...
Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes ... Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated ... Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti- ... "Receptors, Cholecystokinin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
The relationship among plasma cholecystokinin (CCK), pancreatic growth, and food intake was studied in rats over a 2-wk period ... Plasma cholecystokinin and pancreatic growth during adaptation to dietary protein Am J Physiol. 1986 Jul;251(1 Pt 1):G70-4. doi ... The relationship among plasma cholecystokinin (CCK), pancreatic growth, and food intake was studied in rats over a 2-wk period ...
Computer model showing the structure of the terminal fragment of a molecule of the hormone cholecystokinin-8 (CCK-8). Atoms are ... colour-coded (carbon: large grey, hydrogen: small grey, oxygen: red, nitrogen: blue, sulphur: yellow). Cholecystokinin (CCK) is ... cholecystokinin, cholecystokinin-8, compound, control, cut out, cut outs, cut-out, cut-outs, cutout, cutouts, digestion, ... Caption: Cholecystokinin-8 molecule. Computer model showing the structure of the terminal fragment of a molecule of the hormone ...
Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central ... Cholecystokinin (Pancreozymin). Subscribe to New Research on Cholecystokinin A peptide, of about 33 amino acids, secreted by ... cholecystokinin 5 out of 16; 3-yr-old, control 10 out of 11, cholecystokinin 3 out of 8. Gallstone formation was significantly ... which suggests the role of cholecystokinin in the feedback control of pancreatic secretion.". 05/01/2000 - "The cholecystokinin ...
What is cholecystokinin? Meaning of cholecystokinin as a finance term. What does cholecystokinin mean in finance? ... Definition of cholecystokinin in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Cholecystokinin financial definition of cholecystokinin https://financial-dictionary.thefreedictionary.com/cholecystokinin. ... Related to cholecystokinin: enterogastrone, secretin CCK. GOST 7.67 Latin three-letter geocode for the Cocos Islands. The code ...
Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator. GG Turrigiano and AI Selverston ... Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator ... The presence, release, and physiological effects of a cholecystokinin(CCK)-like peptide within the stomatogastric ganglion (STG ... Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator ...
It represents a collection of the most up-to-date information in cholecystokinin (CCK) res ... Cholecystokinin-Receptor Antagonists in Experimental Pancreatic Tumor Growth C. B. H. Lamers, B. R. Douglas, J. B. M. Jansen, R ... Effects of Cholecystokinin Receptor Antagonists in Animal Models C. Niederau, M. Niederau, R. Lüthen, G. Strohmeyer, J. H. ... Role of Cholecystokinin in Regulating Gallbladder Contraction and Pancreatic Secretion in Man: Studies with Loxiglumide ...
  • Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. (pnas.org)
  • Tryptic digestion converted the intact cholecystokinin from all species to a peptide resembling the COOH-terminal octapeptide. (pnas.org)
  • G.J. Dockray, Immunoreactive component resembling cholecystokinin octapeptide in intestine, Nature, 270: 359 (1977). (springer.com)
  • J. Eng, Y.Shiina, Y.C. E. Pan, R. Blacher, M. Stein and R.S. Yalow, Pig Brain contains cholecystokinin octapeptide and several cholecystokinin desoctapeptides, Proc. (springer.com)
  • Thyrotropin releasing hormone (TRH) and cholecystokinin octapeptide (CCK) are endogenous neuropeptides known to inhibit intake of alcohol. (thefreedictionary.com)
  • The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. (biomedsearch.com)
  • 2. Brief applications of the CCK agonist cholecystokinin octapeptide (26-33) sulfated (CCK8S) evoked prolonged spike discharges in nRt neurons but had no direct effects on VB neuron activity. (nih.gov)
  • In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. (jneurosci.org)
  • To elucidate the anti-inflammatory mechanism of an intestinal neuropeptide, sulfated cholecystokinin octapeptide (sCCK-8), the effects of sCCK-8 on lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) mRNA expression and NF-κB activity in pulmonary interstitial macrophages (PIMs) were studied. (wjgnet.com)
  • Cholecystokinin octapeptide (CCK) injected into the medial hypothalamus of the rat has been reported to suppress feeding. (umassmed.edu)
  • The amphibian caerulein skin peptide, the cockroach leukosulphakinin I and II (LSK) peptides, Drosophila melanogaster (Fruit fly) putative CCK-homologues Drosulphakinins I and II, cionin, a Gallus gallus (Chicken) gastrin/cholecystokinin-like peptide and cionin, a neuropeptide from the protochordate Ciona intestinalis belong to the same family. (ebi.ac.uk)
  • Data suggest that endocrine responses differ between jejunal and gastric enteral feeding, with higher peak plasma CCK (cholecystokinin ), PYY (peptide YY ), and GLP-1/2 ( glucagon -like peptides 1/2) concentrations being attained after jejunal feeding. (antikoerper-online.de)
  • Y. Takeda, Y. Takano and H. Kamiya, Effects of cholecystokinin tetra and octa peptides on locomotor activity in mice, Japan. (springer.com)
  • A. Saito, I.D. Goldfine and J.A. Williams, Characterization of receptors for cholecystokinin and related peptides in mouse cerebral cortex, J. Neurochem. (springer.com)
  • The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. (jneurosci.org)
  • To determine whether the regulatory peptides cholecystokinin (CCK) and the CCK-related peptide gastrin are co-expressed by the corneal epithelium. (arvojournals.org)
  • cholecystokinin and gastrin peptides. (thefreedictionary.com)
  • CCKBR is a G protein-coupled receptor for gastrin and cholecystokinin (CCK), which are regulatory peptides of the brain and gastrointestinal tract. (cellsciences.com)
  • Because the human exorbital lacrimal gland contains immuoreactive cholecystokinin (CCK-8) (Abstract # 4165 ARVO 2010), might the rat Harderian gland, a major lacrimal organ in non-primate terrestrial vertebrates, contain enteric peptides, specifically CCK? (arvojournals.org)
  • Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function. (semanticscholar.org)
  • Hommer, DW, Pickar, D & Crawley, JN 1985, ' The effects of cholecystokinin-like peptides in schizophrenics and normal human subjects ', Annals of the New York Academy of Sciences , vol. (elsevier.com)
  • Abstract: Background: Cholecystokinin (CCK) is an anorexigenic hormone. (fu-berlin.de)
  • abstract = "OBJECTIVE: Gallbladder hypomotility in celiac disease has been attributed to decreased cholecystokinin secretion. (elsevier.com)
  • abstract = "Eight neuroleptic-resistant schizophrenic patients were treated with ceruletide, a cholecystokinin-like peptide, in a placebo-controlled, double-blind, crossover study. (elsevier.com)
  • Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. (springer.com)
  • Levels of the opioid-antagonist cholecystokinin in the brain. (encognitive.com)
  • By means of loxiglumide, a potent and highly specific antagonist for cholecystokinin (CCK), the effects of blocking CCK receptors on gastrointestinal motility were investigated in a placebo-controlled study in healthy young men (aged 21-39, mean 24 years). (semanticscholar.org)
  • The gastrin/cholecystokinin-B receptor antagonist L-365,260 reduces basal acid secretion and prevents gastrointestinal damage induced by aspirin, ethanol and cysteamine in the rat. (aspetjournals.org)
  • The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. (biomedsearch.com)
  • BACKGROUND AND PURPOSE: JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK(2) receptors with good pharmacokinetic properties and represents a novel mechanism for the treatment of gastro-oesophageal reflux disease (GORD). (biomedsearch.com)
  • Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion. (bmj.com)
  • Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors. (aspetjournals.org)
  • 3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic membranes. (aspetjournals.org)
  • Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. (semanticscholar.org)
  • A synthetic peptide derivative that is a cholecystokinin receptor antagonist. (semanticscholar.org)
  • Publications] Funakoshi A: 'Effect of a CCK antagonist (CR-1505) on gene expressions of cholecystokinin and secretin in rat intestine. (nii.ac.jp)
  • Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. (harvard.edu)
  • Role of cholecystokinin in the motivational control of instrumental action in rats. (thefreedictionary.com)
  • Role of cholecystokinin as an anti-opio. (encognitive.com)
  • Cholecystokinin (CCK) , formerly called pancreozymin , a digestive hormone released with secretin when food from the stomach reaches the first part of the small intestine ( duodenum ). (britannica.com)
  • Most pancreatic exocrine stimulation comes from the duodenum, which releases cholecystokinin and secretin, targeting acinar and ductal cells, respectively. (thefreedictionary.com)
  • Other than increased blood glucose, arginine and lysine amino acids and gastrointestinal hormones such as gastrin, secretin, cholecystokinin , gastric inhibitory peptide, and growth hormone, cortisol and glucagon have an important role in insulin secretion. (thefreedictionary.com)
  • This test is often combined with the secretin test and is called the secretin-cholecystokinin test. (thefreedictionary.com)
  • Publications] Miyasaka K: 'Involvement of gene expressions of cholecystokinin and secretin in lumianl feedback regulation in conscious rats. (nii.ac.jp)
  • Publications] Funakoshi A: 'Changes in gene expressions of pancreatitis associated protein and pancreatic secretory trypsin inhibitors in experimental pancreatjtis produced by pancreatic duct occlustion in rats : Comparison with gene expressions of cholecystokinin and secretin. (nii.ac.jp)
  • Cholecystokinin And Secretin Uk Clinics log VVG 9192 1461 massage NN 9193 1460 liaison NN 9194 1460 utal JJ. (villa-agata.eu)
  • The key difference between secretin and cholecystokinin is that the secretin is a peptide hormone produced by S cells of the duodenum and jejunum while the cholecystokinin is another peptide hormone secreted by I cells of the duodenum . (differencebetween.com)
  • Among them, secretin and cholecystokinin are two hormones produced and secreted together when foods reach the stomach. (differencebetween.com)
  • What are the Similarities Between Secretin and Cholecystokinin? (differencebetween.com)
  • Cholecystokinin and secretin are two duodenal gland hormones. (differencebetween.com)
  • Secretin and cholecystokinin are two types of hormones of the duodenum. (differencebetween.com)
  • S cells of the duodenum secrete secretin while I cells of the duodenum secrete cholecystokinin. (differencebetween.com)
  • Therefore, this is another difference between secretin and cholecystokinin. (differencebetween.com)
  • Also, secretin is mainly responsible for water homeostasis while cholecystokinin is mainly responsible for fat and protein digestion. (differencebetween.com)
  • The below infographic shows more information on the difference between secretin and cholecystokinin. (differencebetween.com)
  • Also, secretin is a linear peptide comprising of 27 amino acid sequence, while cholecystokinin is a peptide hormone that exists in three types consisting of 33, 59 and 385 amino acid sequences. (differencebetween.com)
  • One hypothesis is that meal-induced secretion of cholecystokinin activates the satiety centre of the hypothalamus in the brain so that the person feels full and stops eating. (britannica.com)
  • A second hypothesis is that, because cholecystokinin inhibits emptying of the stomach, the sensation of satiety may be the result of distension of the stomach. (britannica.com)
  • Cholecystokinin may be the mediator of satiety. (nih.gov)
  • In a study published in the Journal of Nutrition, researchers observed that a single test meal with high-fiber beans produced a two-fold greater increase in the satiety hormone cholecystokinin (CCK), compared to a control test meal without beans. (thefreedictionary.com)
  • Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33. (sigmaaldrich.com)
  • However, since this surgery involves both lower and upper gut segments, we tested the hypothesis that II alters the satiety responses evoked by the classic upper gut peptide cholecystokinin (CCK). (sigmaaldrich.com)
  • Using this assay we have demonstrated that cholecystokinin is important in control of satiety in humans. (clinsci.org)
  • The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. (jci.org)
  • Publications] Miyasaka K: 'Gene expression of cholecystokinin (CCK) and CCK receptors, and its satiety effect in young and old male rats. (nii.ac.jp)
  • Beta-cell glucose sensitivity, insulin clearance, cholecystokinin values, and subjective satiety ratings were unaffected. (mdpi.com)
  • These undifferentiated cells and also presumably immature epithelial cells in the progenitor zone of adult gastric glands were shown to express cholecystokinin-2 (CCK 2 ) receptors and are therefore targets for the trophic action of gastrin. (diva-portal.org)
  • Background & Aims: Three pathways control gastric acid secretion: the gastrin-enterochromaffin-like (ECL) cell axis, the vagus-parietal cell axis, and the cholecystokinin (CCK)-D cell axis. (lu.se)
  • Cholecystokinin plays a major role in maintaining nutritional homeostasis through its involvement in processes such as gastric emptying, gallbladder contraction, and pancreatic exocrine secretion. (multispaninc.com)
  • Cholecystokinin, officially called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. (wikipedia.org)
  • Cholecystokinin, otherwise known as CCK or CCK-PZ, is a hormone that was once called pancreozymin because of its actions on the pancreas. (hormone.org)
  • C. Yanaihara, N. Sugiura, K. Kashimoto, M. Kondo, M. Kawamura, S. Naruse, A. Yasui and N. Yanaihara, Dissociation of pancreozymin (PZ) activity from cholecystokinin (CCK) activity by Na-carboxyacyl CCK-7 and CCK-8 analogues with a substituted glycine. (springer.com)
  • Cholecystokinin, previously called pancreozymin , is synthesised by I-cells and secreted in the duodenum, the first segment of the small intestine, and causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively. (chemeurope.com)
  • and the contraction of the gallbladder , which forces bile into duodenum, an action ascribed to cholecystokinin. (britannica.com)
  • Cholecystokinin is a hormone produced in the I-cells that line the duodenum. (hormone.org)
  • Upon secretion of cholecystokinin when chyme enters the small intestine, the gall bladder releases bile through the cystic duct (joins into the common hepatic and common bile ducts) into the duodenum (Huether, 2008a). (thefreedictionary.com)
  • After IV administration of cholecystokinin, the resultant pancreatic secretion of amylase, trypsin, and lipase is measured by collection through a tube in the duodenum. (thefreedictionary.com)
  • Gastrin-releasing peptide stimulates cholecystokinin secretion in perfused rat duodenum. (mysciencework.com)
  • We examined the effect of porcine gastrin-releasing peptide (GRP-27) and other analogous neuropeptides on cholecystokinin (CCK) secretion from the isolated perfused rat duodenum. (mysciencework.com)
  • Cholecystokinin is one of the duodenum hormones. (differencebetween.com)
  • cholecystokinin type A receptor (CCKAR) (Rikimaru et al. (thefreedictionary.com)
  • We found that mRNA of cholecystokinin type-A receptor (CCKAR) is gradually expressed during postnatal development in rat pancteas, though it is not observed in fetal pancreas. (nii.ac.jp)
  • This assay has high sensitivity and excellent specificity for detection of Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • No significant cross-reactivity or interference between Cholecystokinin A Receptor (CCKAR) and analogues was observed. (uscnk.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Cholecystokinin A Receptor (CCKAR) were tested 20 times on one plate, respectively. (uscnk.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Cholecystokinin A Receptor (CCKAR) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
  • The microplate provided in this kit has been pre-coated with an antibody specific to Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • Upon plate development, the intensity of the emitted light is proportional to the Cholecystokinin A Receptor (CCKAR) level in the sample or standard. (uscnk.com)
  • The secretion of cholecystokinin was examined in STC-1 cells, an intestinal cholecystokinin (CCK)secreting cell line. (rti.org)
  • Cardiac expression of pro- cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons. (antikoerper-online.de)
  • Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. (harvard.edu)
  • The cholecystokinin B receptor also known as CCKBR or CCK 2 is a protein [5] that in humans is encoded by the CCKBR gene . (wikipedia.org)
  • In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. (bibsys.no)
  • The relationship among plasma cholecystokinin (CCK), pancreatic growth, and food intake was studied in rats over a 2-wk period of adaptation from a very low-protein to a very high-protein diet. (nih.gov)
  • With saline infusion there was no premeal increase in plasma cholecystokinin concentration. (clinsci.org)
  • Cholecystokinin (CCK) is a peptide hormone responsible for stimulating the digestion of fat and proteins. (thefreedictionary.com)
  • Cholecystokinin acts as a neuropeptide in the central nervous system as well as acts as a peptide hormone in the gut. (differencebetween.com)
  • Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. (ucl.ac.uk)
  • What's more, the researchers show that rats fed a high-fat diet for a few days become resistant to the glucose-lowering hormone known as cholecystokinin (CCK). (wordnik.com)
  • Potato Extract (Potein) Suppresses Food Intake in Rats through Inhibition of Luminal Trypsin Activity and Direct Stimulation of Cholecystokinin Secretion from Enteroendocrine Cells. (thefreedictionary.com)
  • Publications] Miyasakak K: 'Sex difference in gene expressions of cholecystokinin (CCK) and CCK receptor in young and old rats. (nii.ac.jp)
  • Publications] Miyasaka K: 'Changes in gene expression of cholecystokinin-A receptor after induction of pancreatitis by pancreatic duct occlusion in rats. (nii.ac.jp)
  • Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. (chemeurope.com)
  • To test the temporal activity of these independent and parallel GABAergic inputs, we recorded the precise spike timing of identified cholecystokinin interneurons during hippocampal network oscillations in anesthetized rats and determined their molecular expression profiles and synaptic targets. (ox.ac.uk)
  • The firing patterns of some interneurons recorded in drug-free behaving rats were similar to cholecystokinin cells in anesthetized animals. (ox.ac.uk)
  • The presence, release, and physiological effects of a cholecystokinin(CCK)-like peptide within the stomatogastric ganglion (STG) of the lobster, Panulirus interruptus, are described. (jneurosci.org)
  • 2. In this study cholecystokinin-8 was infused intravenously to six healthy subjects in doses that reproduced physiological post-prandial concentrations. (clinsci.org)
  • Your search returned 687 cholecystokinin ELISA ELISA Kit across 21 suppliers. (biocompare.com)
  • Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. (harvard.edu)
  • Cholecystokinin (CCK) is a family of hormones responsible for promoting the digestion of fats and proteins. (sciencephoto.com)
  • These possess receptors for and functional actions of gastrointestinal hormones such as amylin, cholecystokinin , ghrelin, and peptide YY in the area postrema and subfornical organ. (thefreedictionary.com)
  • In addition, variations with the cholecystokinin gene have been connected to obesity, but the reason for this is not yet known. (hormone.org)
  • The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. (lu.se)
  • We also found two base changes in promoter region of human cholecystokinin type-A receptor gene, a G to T change in -128 nucleotide and an Ato G change in -81 nucleotide. (nii.ac.jp)
  • Publications] Kimihiko Matsusue, Soichi Takiguchi, Yutaka Takata, Akihiko Funakoshi, Kyoko Miyasaka, Akira Kono: 'Expression of Cholecystokinin Type A Receptor Gene Correates with DNA Demethylation during Postnatal Development of Rat Pancreas'Biochem.Biophys.Res.Commun. (nii.ac.jp)
  • Publications] Akihiro Funakoshi, Kyoko Miyasaka, Hideo Matsumoto, Shunji Yamamori, Soichi Takiguchi, Kazuhiro Kataoka, Yutaka Takata, Kimihiko Matsusue, Akira Kono, Hiroshi Shimokata: 'Gene structure of human cholecystokinin(CCK) type-A receptor : body fat content is related CCK type-A receptor gene promoter polymorphism'FEBS Letters. (nii.ac.jp)
  • Publications] Kimihiko Matsusue, Soichi Takiguchi, Yutaka Takata, Akihiko Funakoshi, Kyoko Miyasaka, Akira Kono: 'Expression of Cholecystokinin Type A Receptor Gene Correates with DNA Demethylation during Postnatal Development of Rat Pancreas'Biochem. (nii.ac.jp)
  • Publications] Akihiro Funakoshi, Kyoko Miyasaka, Hideo Matsumoto, Shunji Yamamori, Kazuhiro Kataoka, Yutaka Takata, Kimihiko Matsusue, Akira Kono, Hiroshi Shimokata: 'Gene structure of human cholecystokinin(CCK)type-A receptor : body fat content is related CCK type-A receptor gene promoter polymorphism'FEBS Letters. (nii.ac.jp)
  • Publications] Funakoshi A: 'An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. (nii.ac.jp)
  • Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. (nih.gov)
  • In the present study, immunohistochemical techniques were used to analyze neurons in the rat ABL that contain cholecystokinin (CCK). (nih.gov)
  • 1. The thalamic reticular nucleus (nRt) is innervated by cholecystokinin (CCK)-containing neurons and contains CCK binding sites. (nih.gov)
  • Background and Aims: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). (elsevier.com)
  • Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. (ox.ac.uk)
  • Secretory and electrophysiological properties of STC-1 cells, a cholecystokinin-secreting cell line, were examined with a radioimmunoassay and patch-clamp recording techniques. (rti.org)
  • A sensitive radioimmunoassay for cholecystokinin (CCK) has been developed. (garvan.org.au)
  • Plasma concentrations of cholecystokinin were measured using a novel sensitive and specific radioimmunoassay. (clinsci.org)
  • 4. This paper describes a novel radioimmunoassay for measurement of plasma concentrations of cholecystokinin. (clinsci.org)
  • METHODS: Gallbladder volume and plasma levels of cholecystokinin and somatostatin were measured by ultrasonography and radioimmunoassay, respectively, at 0 time and 30, 60, 75, and 90 min after an oral fatty meal (227 kcal, 45% fat) in 10 celiac patients at diagnosis and after 18 months of successful gluten-free diet and in 10 healthy subjects. (elsevier.com)
  • Frozen Cells validated for calcium testing: Cholecystokinin CCK1 receptor, human recombinant, in 1321N1 host cell. (perkinelmer.com)
  • It is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to gastrin, another gastrointestinal hormone. (wikipedia.org)
  • Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin . (rug.nl)
  • Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviors. (ebi.ac.uk)
  • While research is still underway to determine what impact cholecystokinin has on obesity and health, your doctor can help you determine if your hormones may be impacting your health. (hormone.org)
  • It may also increase the level of hormones in the gut (such as cholecystokinin ), which is another way to control your appetite. (wordnik.com)
  • Pine nut oil contains pinolenic acid, a fatty acid that stimulates the body to produce two natural appetite suppressants: the hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). (wordnik.com)
  • [2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide . (rug.nl)
  • There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide. (wikipedia.org)
  • It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. (springer.com)
  • Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor. (semanticscholar.org)
  • Minigastrin (MG) analogs show high affinity to the cholecystokinin-2 receptor (CCK2R) and have therefore been intensively studied to find a suitable analog for imaging and treatment of CCK2R-expressing tumors. (thno.org)
  • Two photolabile cholecystokinin analogues were developed and characterized as representing high-affinity, fully biologically active probes with sites of covalent attachment at positions 28 and 31. (monash.edu)
  • The failure to detect intact cholecystokinin in extracts from monkey or dog by using an antiserum developed by immunization with porcine cholecystokinin is presumed to be due to marked species differences in the NH2-terminal portion of the molecule. (pnas.org)
  • Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). (springer.com)
  • Miller LJ, Gao F. Structural basis of cholecystokinin receptor binding and regulation. (springer.com)
  • Obese people have been found to have less than the average levels of cholecystokinin, which may contribute to problems with increased appetite and further difficulty with weight loss. (hormone.org)
  • These results indicate that, in STC-1 cells, L-phenylalanine stimulates release of cholecystokinin via a calcium-dependent process. (rti.org)
  • Slendesta[R] is an all-natural ingredient that promotes the body's release of cholecystokinin , a peptide that makes a person feel fuller. (thefreedictionary.com)
  • STC-1 cells may serve as a model system to study the electrophysiological and secretory mechanisms involved in the release of cholecystokinin. (rti.org)
  • Ghrelin, neuropeptide Y (NPY) and cholecystokinin (CCK) in blunt snout bream (Megalobrama amblycephala): cDNA cloning, tissue distribution and mRNA expression changes responding to fasting and refeeding. (thefreedictionary.com)
  • This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of newborn calves. (antikoerper-online.de)
  • This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of neonatal pigs. (antikoerper-online.de)
  • Long-term comparative effect of cholecystokinin and gastrin on mouse stomach, antrum, intestine and exocrine pancreas. (thefreedictionary.com)
  • Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. (springer.com)
  • This work focuses on the use of photoaffinity labeling and molecular modeling to elucidate the structural basis of binding a natural peptide ligand to a family A G protein-coupled receptor, the type 1 cholecystokinin receptor. (monash.edu)
  • We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. (ox.ac.uk)
  • Desai, AJ & Miller, LJ 2012, ' Sensitivity of cholecystokinin receptors to membrane cholesterol content ', Frontiers in Endocrinology , vol. 3, no. (elsevier.com)
  • At the same time, cholecystokinin increases the amount of fluid and enzymes released by the pancreas, so the body better digests food. (hormone.org)
  • R.B. Innis and S.H. Snyder, Distinct cholecystokinin receptors in brain and pancreas, Proc. (springer.com)
  • The hormone cholecystokinin (CCK) was discovered in 1928 by Ivy and Oldberg, based on its ability to stimulate gallbladder contraction. (springer.com)
  • Computer model showing the structure of the terminal fragment of a molecule of the hormone cholecystokinin-8 (CCK-8). (sciencephoto.com)
  • 1. Intravenous infusions of the brain/gut hormone, cholecystokinin, have been shown to reduce food intake in a subsequent test meal. (clinsci.org)
  • In addition to the above the report determines cholecystokinin fragment 30-33 amide hydrochloride consumers. (marketpublishers.com)
  • In this study gallbladder emptying and cholecystokinin and somatostatin plasma levels were evaluated in response to a fatty meal in patients with celiac disease at diagnosis and after long-term gluten-free diet and in controls. (elsevier.com)
  • CONCLUSIONS: In patients at diagnosis, elevated somatostatin levels were associated with increased gallbladder fasting volume, whereas decreased cholecystokinin secretion was responsible for the reduced gallbladder emptying. (elsevier.com)
  • Zusätzlich bieten wir Ihnen Cholecystokinin Kits (89) und Cholecystokinin Proteine (20) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • Cholecystokinin receptors are a family of G protein-coupled receptors consisting of CCK 1 and CCK 2 receptors. (multispaninc.com)
  • The cholecystokinin (CCK) receptor on the rat pancreatic acinar cell is a guanine nucleotide-binding protein (G protein)-coupled receptor, which was recently demonstrated to be phosphorylated in response to agonist stimulation (Klueppelberg et al. (elsevier.com)
  • Stimulation of cholecystokinin secretion was seen after exposure to agents anticipated to increase the level of intracellular calcium, including thapsigargin (8 muM), bombesin (50 nM), potassium-induced depolarization (50 mM), or after blockade of potassium channels with barium chloride (2 mM). (rti.org)
  • Cholecystokinin receptor A (CCK-AR) mediates signals resulting in gallbladder contraction. (ovid.com)
  • Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. (regionh.dk)
  • Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists. (semanticscholar.org)
  • During cholecystokinin infusion, plasma concentrations increased from 0.45 ± 0.06 pmol/l to 7.28 ± 2.43 pmol/l immediately before the meal. (clinsci.org)
  • Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. (biomedcentral.com)
  • Cholecystokinin belongs to the gastrin family of peptide groups. (frontiersin.org)
  • The cholecystokinin B receptor is stimulated by CCK and gastrin in the stomach during digestion. (wikipedia.org)
  • If toxins are swallowed, bitter-taste receptors in the gut sense them and trigger the production of a hormone called cholecystokinin that both suppresses appetite and slows the movement of food from the stomach to the small intestine. (wordnik.com)
  • Most of them emanate from the digestive tract, which releases chemical messengers including cholecystokinin , glucagon-like peptide and peptide YY when the stomach and intestines are full. (wordnik.com)
  • Cholecystokinin (CCK) modulates contractility of the gallbladder, the sphincter of Oddi, and the stomach. (jci.org)
  • Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine. (semanticscholar.org)
  • Each Cholecystokinin Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Cholecystokinin polyclonal antibodies and browse our Cholecystokinin monoclonal antibody catalog. (novusbio.com)
  • Immunohistochemical staining was by a rabbit polyclonal antibody marketed as Anti-Cholecystokinin (26-33) (sulfated CCK-8) by Sigma-Aldrich. (arvojournals.org)