AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and Processes
CholecystokininReceptors, CholecystokininReceptor, Cholecystokinin AReceptor, Cholecystokinin BSincalideDevazepideProglumideBenzodiazepinonesTetragastrinPancreasGastrinsGallbladderGallbladder EmptyingAmylasesSatiationSecretinCeruletideGabexateHormone AntagonistsDuodenumSatiety ResponseGastrointestinal HormonesPancreatic JuicePancreatic PolypeptideEnteroendocrine CellsEatingGastric EmptyingPentagastrinBombesinCholecystographyPeptide YYAzaserinePancreas, ExocrineTechnetium Tc 99m DisofeninImino AcidsChymotrypsinogenBiliopancreatic DiversionSphincter of OddiPeptonesPhenylurea CompoundsGastrointestinal MotilityAppetite RegulationAppetiteRats, Sprague-DawleyVagus NerveMeglumineDibutyryl Cyclic GMPStomachHungerPostprandial PeriodBiliary DyskinesiaDose-Response Relationship, DrugRats, Inbred StrainsCholagogues and CholereticsNodose GanglionTrypsinogenSomatostatinVasoactive Intestinal PeptideRadioimmunoassayCarbacholBenzodiazepinesTechnetium Tc 99m LidofeninCystic DuctGlobulinsPentanoic AcidsAppetite DepressantsPylorusTrypsin InhibitorsNeuropeptides
Cholecystokinin
A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
Receptors, Cholecystokinin
Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.
Receptor, Cholecystokinin A
A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.
Receptor, Cholecystokinin B
A subtype of cholecystokinin receptor found primarily in the CENTRAL NERVOUS SYSTEM and the GASTRIC MUCOSA. It may play a role as a neuromodulator of dopaminergic neurotransmission the regulation of GASTRIC ACID secretion from GASTRIC PARIETAL CELLS.
Sincalide
An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.
Devazepide
A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.
Proglumide
A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
Benzodiazepinones
Tetragastrin
L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.
Pancreas
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Gastrins
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
Gallbladder
A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.
Gallbladder Emptying
A process whereby bile is delivered from the gallbladder into the duodenum. The emptying is caused by both contraction of the gallbladder and relaxation of the sphincter mechanism at the choledochal terminus.
Amylases
A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.
Satiation
Full gratification of a need or desire followed by a state of relative insensitivity to that particular need or desire.
Secretin
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
Ceruletide
A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.
Gabexate
A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Hormone Antagonists
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
Duodenum
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Satiety Response
Behavioral response associated with the achieving of gratification.
Gastrointestinal Hormones
HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.
Pancreatic Juice
The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.
Pancreatic Polypeptide
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Enteroendocrine Cells
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
Eating
The consumption of edible substances.
Gastric Emptying
The evacuation of food from the stomach into the duodenum.
Pentagastrin
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
Bombesin
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
Cholecystography
Radiography of the gallbladder after ingestion of a contrast medium.
Peptide YY
A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.
Azaserine
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
Pancreas, Exocrine
The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.
Technetium Tc 99m Disofenin
A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)
Imino Acids
Chymotrypsinogen
Biliopancreatic Diversion
A surgical procedure which diverts pancreatobiliary secretions via the duodenum and the jejunum into the colon, the remaining small intestine being anastomosed to the stomach after antrectomy. The procedure produces less diarrhea than does jejunoileal bypass.
Sphincter of Oddi
The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
Peptones
Derived proteins or mixtures of cleavage products produced by the partial hydrolysis of a native protein either by an acid or by an enzyme. Peptones are readily soluble in water, and are not precipitable by heat, by alkalis, or by saturation with ammonium sulfate. (Dorland, 28th ed)
Phenylurea Compounds
Compounds that include the amino-N-phenylamide structure.
Gastrointestinal Motility
The motor activity of the GASTROINTESTINAL TRACT.
Appetite Regulation
Physiologic mechanisms which regulate or control the appetite and food intake.
Appetite
Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Vagus Nerve
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Meglumine
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
Dibutyryl Cyclic GMP
N-(1-Oxobutyl)-cyclic 3',5'-(hydrogen phosphate)-2'-butanoate guanosine. A derivative of cyclic GMP. It has a higher resistance to extracellular and intracellular phosphodiesterase than cyclic GMP.
Stomach
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Hunger
The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH.
Postprandial Period
The time frame after a meal or FOOD INTAKE.
Biliary Dyskinesia
A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Cholagogues and Choleretics
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
Nodose Ganglion
The inferior (caudal) ganglion of the vagus (10th cranial) nerve. The unipolar nodose ganglion cells are sensory cells with central projections to the medulla and peripheral processes traveling in various branches of the vagus nerve.
Trypsinogen
The inactive proenzyme of trypsin secreted by the pancreas, activated in the duodenum via cleavage by enteropeptidase. (Stedman, 25th ed)
Somatostatin
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Vasoactive Intestinal Peptide
A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).
Radioimmunoassay
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Carbachol
A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Benzodiazepines
A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
Technetium Tc 99m Lidofenin
A nontoxic radiopharmaceutical that is used in RADIONUCLIDE IMAGING for the clinical evaluation of hepatobiliary disorders in humans.
Cystic Duct
The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.
Globulins
Pentanoic Acids
Appetite Depressants
Agents that are used to suppress appetite.
Pylorus
The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.
Trypsin Inhibitors
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
Neuropeptides
Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin. (1/1430)

1. Proliferative effects of CCK peptides have been examined in rat anterior pituitary GH3 cells, which express CCK2 receptors. 2. CCK-8s, gastrin(1-17) and its glycine-extended precursor G(1-17)-Gly, previously reported to cause proliferation via putative novel sites on AR4-2J and Swiss 3T3 cells, elicited significant dose dependent increases of similar magnitude in [3H]thymidine incorporation over 3 days in serum-free medium of 39 +/- 10% (P < 0.01, n = 20), 37 +/- 8% (P < 0.01, n = 27) and 41 +/- 6% (P < 0.01, n = 36) respectively. 3. CCK-8s and gastrin potentially stimulated mitogenesis (EC50 values 0.12 nM and 3.0 nM respectively), whilst G-Gly displayed similar efficacy but markedly lower potency. L-365,260 consistently blocked each peptide. The CCK2 receptor affinity of G-Gly in GH3 cells was 1.09 microM (1.01;1.17, n = 6) and 5.53 microM (3.71;5.99, n = 4) in guinea-pig cortex. 4. 1 microM G-Gly weakly stimulated Ca2+ increase, eliciting a 104 +/- 21% increase over basal Ca2+ levels, and was blocked by 1 microM L-365,260 whilst CCK-8s (100 nM) produced a much larger Ca2+ response (331 +/- 14%). 5. Insulin dose dependently enhanced proliferative effects of CCK-8s with a maximal leftwards shift of the CCK-8s curve at 100 ng ml(-1) (17 nM) (EC50 decreased 500 fold, from 0.1 nM to 0.2 pM; P < 0.0001). 10 microg ml(-1) insulin was supramaximal reducing the EC50 to 5 pM (P = 0.027) whilst 1 ng ml(-1) insulin was ineffective. Insulin weakly displaced [125I]BHCCK binding to GH3 CCK2 receptors (IC50 3.6 microM). 6. Results are consistent with mediation of G-Gly effects via CCK2 receptors in GH3 cells and reinforce the role of CCK2 receptors in control of cell growth. Effects of insulin in enhancing CCK proliferative potency may suggest that CCK2 and insulin receptors converge on common intracellular targets and indicates that mitogenic stimuli are influenced by the combination of extracellular factors present.  (+info)

Diazepam-binding inhibitor33-50 elicits Ca2+ oscillation and CCK secretion in STC-1 cells via L-type Ca2+ channels. (2/1430)

We recently isolated and characterized 86-amino acid CCK-releasing peptide from porcine intestinal mucosa. The sequence of this peptide is identical to that of porcine diazepam-binding inhibitor (DBI). Intraduodenal administration of DBI stimulates the CCK release and elicits pancreatic secretion in rats. In this study we utilized a murine tumor cell line (STC-1 cells) that contains CCK to examine if DBI directly acts on these cells to stimulate CCK release. We investigated the cellular mechanisms responsible for this action. We showed that DBI33-50, a biologically active fragment of DBI1-86, significantly stimulated CCK secretion in STC-1 cells. This action was abolished by Ca2+-free medium. The mean basal intracellular Ca2+ concentration ([Ca2+]i) was 52 nM in fura 2-loaded STC-1 cells. DBI33-50 (1-1,000 nM) elicited Ca2+ oscillations; DBI33-50 (10 nM) increased the oscillation frequency to 5 cycles/10 min and elicited a net [Ca2+]i increase (peak - basal) to 157 nM. In contrast, bombesin and forskolin caused an initial transient [Ca2+]i followed by a small sustained [Ca2+]i plateau. Withdrawal of extracellular Ca2+ abolished Ca2+ oscillations stimulated by DBI33-50. L-type Ca2+ channel blockers nifedipine and diltiazem (3-10 microM) markedly attenuated DBI-stimulated Ca2+ oscillations. In other cell types L-type Ca2+ channels are activated by cAMP-protein kinase A. DBI33-50 failed to stimulate cAMP formation in STC-1 cells. Similarly, DBI33-50 had no effect on myo-inositol 1,4, 5-trisphosphate concentration ([IP3]), whereas bombesin caused an eightfold increase in [IP3] over basal. In addition, inhibitors of phospholipase C (U-73122), phospholipase A2 (ONO-RS-082), and protein tyrosine kinase (genistein) did not alter the Ca2+ oscillations elicited by DBI33-50. It appears that DBI33-50 acts directly on STC-1 cells to elicit Ca2+ oscillations via the voltage-dependent L-type Ca2+ channels, resulting in the secretion of CCK. Mediation of this action is by intracellular mechanisms independent of the traditional signal transduction pathways, including phospholipase C, phospholipase A2, protein tyrosine kinase, and cAMP systems.  (+info)

The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects. (3/1430)

AIMS: Somatostatin analogues (e.g. vapreotide) are used for treatment of acromegaly, endocrine tumours and variceal bleeding. The pharmacodynamic effects of vapreotide have, however, not been documented in the gastrointestinal tract. The aim of this study was to investigate the effects of continuous vapreotide administration on gastric acidity, gallbladder contraction and hormone release. METHODS: Ten healthy males participated in this randomised, placebo-controlled, double-blind, crossover trial. A constant vapreotide (or placebo) infusion (1.5 mg day(-1) s.c.) was given for 7 days with a portable pump. Intragastric pH was monitored on days 2 and 7. Gallbladder volume was sonographically assessed and the maximal ejection fraction was calculated. In addition basal and postprandial plasma levels of gastrin and cholecystokinin (CCK) were measured. RESULTS: After an initial increase in the median 24 h intragastric pH to a value of 2.6 on day 2, vapreotide's effect on pH decreased: (day 7: median pH=1.9; respective placebo values were 1.7 and 1.5). On the same days with vapreotide treatment, gallbladder contraction and plasma levels of CCK were reduced; maximal ejection fractions after meal stimulation were 18% and 20% (respective placebo values were 57% and 62%). Plasma gastrin levels were not changed with vapreotide treatment. CONCLUSIONS: The short lasting effect of vapreotide on intragastric acidity suggests a down-regulation of somatostatin receptors during treatment. The lack of effect on gastrin indicates that the effects on gastric pH are not mediated by gastrin. Constant vapreotide infusion (but not placebo) reduced gallbladder contraction suggesting a long-lasting effect on biliary function.  (+info)

Involvement of RhoA and its interaction with protein kinase C and Src in CCK-stimulated pancreatic acini. (4/1430)

We evaluated intracellular pathways responsible for the activation of the small GTP-binding protein Rho p21 in rat pancreatic acini. Intact acini were incubated with or without CCK and carbachol, and Triton X-100-soluble and crude microsomes were used for Western immunoblotting. When a RhoA-specific antibody was used, a single band at the location of 21 kDa was detected. CCK (10 pM-10 nM) and carbachol (0.1-100 microM) dose dependently increased the amount of immunodetectable RhoA with a peak increase occurring at 3 min. High-affinity CCK-A-receptor agonists JMV-180 and CCK-OPE (1-1,000 nM) did not increase the intensities of the RhoA band, suggesting that stimulation of RhoA is mediated by the low-affinity CCK-A receptor. Although an increase in RhoA did not require the presence of extracellular Ca2+, the intracellular Ca2+ chelator 1, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-AM abolished the appearance of the RhoA band in response to CCK and carbachol. The Gq protein inhibitor G protein antagonist-2A (10 microM) and the phospholipase C (PLC) inhibitor U-73122 (10 microM) markedly reduced RhoA bands in response to CCK. The protein kinase C (PKC) activator phorbol ester (10-1,000 nM) dose dependently increased the intensities of the RhoA band, which were inhibited by the PKC inhibitor K-252a (1 microM). The pp60(c-src) inhibitor herbimycin A (6 microM) inhibited the RhoA band in response to CCK, whereas the calmodulin inhibitor W-7 (100 microM) and the phosphoinositide 3-kinase inhibitor wortmannin (6 microM) had no effect. RhoA was immunoprecipitated with Src, suggesting association of RhoA with Src. Increases in mass of this complex were observed with CCK stimulation. In permeabilized acini, the Rho inhibitor Clostridium botulinum C3 exoenzyme dose dependently inhibited amylase secretion evoked by a Ca2+ concentration with an IC50 of C3 exoenzyme at 1 ng/ml. We concluded that the small GTP-binding protein RhoA p21 exists in pancreatic acini and appears to be involved in the mediation of pancreatic enzyme secretion evoked by CCK and carbachol. RhoA pathways are involved in the activation of PKC and Src cascades via Gq protein and PLC.  (+info)

Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. (5/1430)

The gut peptide CCK is a nutrient-related signal important to the control of food intake. In the present studies, we observed that a single intraperitoneal injection of CCK (1-2 microgram/kg) given 2-3 h after intracerebroventricular leptin (2-5 microgram) reduced body weight and chow intake over the ensuing 48 h more than did leptin alone. CCK alone had no effect on either 48-h chow intake or body weight but significantly reduced feeding during a 30-min sucrose test. However, reduction of 30-min sucrose intake by CCK was not enhanced by prior intracerebroventricular leptin. The present data suggest that CCK can contribute to the regulation of body weight when central leptin levels are elevated.  (+info)

Hormone-induced secretory and nuclear translocation of calmodulin: oscillations of calmodulin concentration with the nucleus as an integrator. (6/1430)

Many important enzyme activities are regulated by Ca2+-dependent interactions with calmodulin (CaM). Some of the most important targets for CaM action are in the nucleus, and Ca2+-dependent CaM translocation into this organelle has been reported. Hormone-evoked cytosolic Ca2+ signals occur physiologically as oscillations, but, so far, oscillations in CaM concentration have not been described. We loaded fluorescent-labeled CaM into pancreatic acinar cells and monitored the fluorescence in various regions by confocal microscopy. Sustained high concentrations of the hormone cholecystokinin or the neurotransmitter acetylcholine evoked a transient movement of cytosolic CaM from the basal nonnuclear area into the secretory granule region and, thereafter, a more substantial and prolonged translocation of CaM into the nucleoplasm. About 50% of the CaM that bound Ca2+ translocated. At a lower hormone concentration, evoking Ca2+ oscillations, regular spikes of increased CaM concentration were seen in the secretory granule region with mirror image spikes of decreased CaM concentration in the basal nonnuclear region. The nucleus was able to integrate the Ca2+ spike-evoked pulses of CaM translocation into a sustained elevation of the nucleoplasmic concentration of this protein.  (+info)

Supraspinal neurotensin-induced antianalgesia in mice is mediated by spinal cholecystokinin. (7/1430)

Intracerebral injection of neurotensin into specific brain loci in rats produces hyperalgesia due to the release of cholecystokinin (CCK) in the spinal cord. The present purpose was to show in another species that neurotensin can antagonize the antinociceptive action of morphine through the spinal CCK mechanism in mice. Neurotensin given intracerebroventricularly (i.c.v.) at doses higher than 100 ng produced antinociception in the tail flick test. However, at lower doses between 1 pg to 25 ng, neurotensin antagonized the antinociceptive action of morphine given intrathecally (i.t.), thus demonstrating the antianalgesic activity of neurotensin. The rightward shift in the morphine dose-response curve produced by i.c.v. neurotensin was eliminated by an i.t. pretreatment with CCK8 antibody (5 microl of antiserum solution diluted 1:1000). I.t. administration of lorglumide, a CCK(A)-receptor antagonist (10-1000 ng), and PD135,158, a CCK(B)-receptor antagonist (250-500 ng), also eliminated the antianalgesic action of neurotensin. Thus, the mechanism of the antianalgesic action of neurotensin given i.c.v. involved spinal CCK. This mode of action is similar to that for the antianalgesic action of supraspinal pentobarbital which also involves spinal CCK.  (+info)

Effects of alverine citrate on cat intestinal mechanoreceptor responses to chemical and mechanical stimuli. (8/1430)

BACKGROUND: Alverine citrate is commonly used in the treatment of painful affections of the colon. AIM: To determine whether alverine citrate acts on the vagal sensory endings. METHODS: Unitary recordings were performed at the level of the vagal fibres in the nodose ganglion of anaesthetized cats using extracellular glass microelectrodes, and the patterns of response to chemical and mechanical stimuli applied to identified vagal intestinal mechanoreceptors were studied. RESULTS: The intestinal mechanoreceptors located at the endings of type C vagal fibres responded mainly to mechanical stimuli (distension and contraction), but also responded to chemical substances (cholecystokinin and substance P). The most conspicuous effect of alverine (2 mg/kg) was that it significantly inhibited the pattern of vagal activity produced in response to either cholecystokinin (5-10 microg/kg), substance P (5-10 microg/kg) or phenylbiguanide (5-10 microg/kg), a 5-HT3 receptor agonist. On the other hand, the unitary vagal response to the mechanical distension was slightly enhanced by alverine, as was any spontaneous activity present. CONCLUSIONS: Based on the present data, alverine citrate can be said to decrease the sensitivity of the intestinal mechanoreceptors, which is consistent with its previously established anti-spasmodic effects.  (+info)

Endogenous cholecystokinin is not a major regulator of food intake in the chicken<...Endogenous cholecystokinin is not a major regulator of food intake in the chicken<...
TY - JOUR. T1 - Endogenous cholecystokinin is not a major regulator of food intake in the chicken. AU - Choi, Y. H.. AU - Furuse, M.. AU - Satoh, S.. AU - Okumura, J.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - This study investigated whether or not endogenous cholecystokinin exerts satiety effects in chickens. After several doses (0, 1, 2 and 4 μg·kg body weight-1) of intravenous injection of caerulein, the bile flow was increased in a dose-dependent fashion. However, the pharmacological level of caerulein failed to suppress the food intake of chickens. Two potent stimulators of endogenous cholecystokinin, i.e., soybean trypsin inhibitor and phenylalanine were administered to chickens before feeding and food intake was determined over 2 h. The soybean trypsin inhibitor and phenylalanine did not alter food intake. Devazepide, a cholecystokinin-A receptor antagonist, significantly decreased amylase release from the dispersed chicken pancreatic acini stimulated by caerulein. However, devazepide did not ...
https://kyushu-u.pure.elsevier.com/en/publications/endogenous-cholecystokinin-is-not-a-major-regulator-of-food-intak
CALCIUM-DEPENDENT REGULATION OF CHOLECYSTOKININ SECRETION AND POTASSIUM CURRENTS IN STC-1 CELLS | RTICALCIUM-DEPENDENT REGULATION OF CHOLECYSTOKININ SECRETION AND POTASSIUM CURRENTS IN STC-1 CELLS | RTI
Secretory and electrophysiological properties of STC-1 cells, a cholecystokinin-secreting cell line, were examined with a radioimmunoassay and patch-clamp recording techniques. Stimulation of cholecystokinin secretion was seen after exposure to agents anticipated to increase the level of intracellular calcium, including thapsigargin (8 muM), bombesin (50 nM), potassium-induced depolarization (50 mM), or after blockade of potassium channels with barium chloride (2 mM). The secretory effects of these agents were blocked by pretreatment with the calcium channel blocker diltiazem (1 muM).
https://www.rti.org/publication/calcium-dependent-regulation-cholecystokinin-secretion-and-potassium-currents-stc-1
The Effect of Whole Gut Irrigation on Contractile Responses of Guinea Pig Gallbladder, Ileum, and Tissue Cholecystokinin Levels...The Effect of Whole Gut Irrigation on Contractile Responses of Guinea Pig Gallbladder, Ileum, and Tissue Cholecystokinin Levels...
Aim An experimental study was performed to evaluate the effect of whole gut irrigation (WGI) solutions on contractile responses of the gallbladder and ileum and also on tissue cholecystokinin (CCK) levels. ...
https://avesis.hacettepe.edu.tr/yayin/58c7931f-a53a-4b44-8467-cca295d2fbc0/the-effect-of-whole-gut-irrigation-on-contractile-responses-of-guinea-pig-gallbladder-ileum-and-tissue-cholecystokinin-levels
Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats<...Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats<...
TY - JOUR. T1 - Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. AU - de Lartigue, Guillaume. AU - Barbier de la Serre, Claire. AU - Espero, Elvis. AU - Lee, Jennifer. AU - Raybould, Helen E. PY - 2012/3/7. Y1 - 2012/3/7. N2 - Background and Aims: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby increasing their sensitivity to CCK. In response to a chronic ingestion of a high fat diet, VAN develop leptin resistance and the satiating effects of CCK are reduced. We tested the hypothesis that leptin resistance in VAN is responsible for reducing CCK signaling and satiation. Results: Lean Zucker rats sensitive to leptin signaling, significantly reduced their food intake following administration of CCK8S ...
https://ucdavis.pure.elsevier.com/en/publications/leptin-resistance-in-vagal-afferent-neurons-inhibits-cholecystoki
Direct linkDirect link
Sex hormones including estrogens affect brain areas involved in mood and cognition in addition to directly controlling reproduction and reproductive behavior. We studied the effect of pregnancy and puerperium on the concentrations of cholecystokinin (CCK), neuropeptide Y (NPY), substance P (SP) and galanin in tissue extracts from the rat striatum, frontal cortex and the hippocampal formation by means of radioimmunoassay. The most profound effects were found in the frontal cortex. Thus, cholecystokinin-like immunoreactivity (CCK-LI) was increased by 40 % during late pregnancy (p , 0.01) compared to estrous whereas SP-LI and galanin-LI decreased 25 % and 10 %, respectively. Postpartum, CCKLI decreased by 26% compared to pregnancy (p , 0.05) whereas SP-LI and galanin-LI were increased to a level above estrous (SP, P , 0.01; galanin, P , 0.05). No significant effect was observed in NPY-LI in this area. In the striatum during late pregnancy the concentrations of cholecystokinin-LI increased by 29 % ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2%3A346998
Cholecystokinin financial definition of cholecystokininCholecystokinin financial definition of cholecystokinin
Definition of cholecystokinin in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is cholecystokinin? Meaning of cholecystokinin as a finance term. What does cholecystokinin mean in finance?
https://financial-dictionary.thefreedictionary.com/cholecystokinin
Comparative studies on cholecystokinin receptorsComparative studies on cholecystokinin receptors
1. A scheme of synthesis was developped for cholecystokinin (CCK 26-33, using solid-phase methodology and successfully applied to the synthesis of its C- and N-terminal fragments. 2. Using CCK 30-33 as model, it was found that deprotection of the ?-phenacyl ester, with a 1 M solution of sodium thiophenoxide in DMF, leads to the formation of an aminosuccylnyl peptide, prior to ammonolysis. 3. Selenophenol reagent successfully removes the ?-phenacyl ester on protected CCK 32-33 and on protected CCK 30-33 polymer prior to ammonolytic cleavage of peptides from the resin. 4. Treatment of Boc-Asp(?-OPac)-Tyr(0-2,4-Dnp)-Met-Gly-Trp(Nin-For)-Met-Asp(?-OPac)-Phe-polymer with a 1 M solution of selenophenol in DMF, leads to irreversible rearrangement of the 0-2,4-dinitrophenyl ether. 5. Undesirable side-reactions can be avoided by sequential deprotections and cleavage. The 0-2,4-dinitrophenyl ether is removed by thiolysis following by selenolysis of the ?-phenacyl esters. Cleavage of the peptide from the ...
http://savoirs.usherbrooke.ca/handle/11143/11736
Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents<...Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents<...
TY - JOUR. T1 - Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents. AU - Gulyás, A. I.. AU - Görcs, T.. AU - Freund, T.. PY - 1990. Y1 - 1990. N2 - The termination pattern of septohippocampal axons visualized by anterograde transport of Phaseolus vulgaris leucoagglutinin was studied in the hippocampal formation in the rat, with special reference to the innervation of neurons immunoreactive for the neuroactive peptides cholecystokinin, somatostatin or vasoactive intestinal polypeptide. The type I, GABAergic, septohippocampal afferents were shown to terminate on neurons immunoreactive for each of the three peptides. The cholecystokinin-like immunoreactive neurons in all regions, and the somatostatin-immunoreactive cells in stratum oriens of CA1 region were the most preferred targets. Cholecystokinin-immunoreactive cells, especially those in the granule cell layer of the dentate gyrus, were often seen to be contacted by type II (presumed ...
https://hungary.pure.elsevier.com/en/publications/innervation-of-different-peptide-containing-neurons-in-the-hippoc
Cholecystokinin A Receptor Summary Report | CureHunterCholecystokinin A Receptor Summary Report | CureHunter
Cholecystokinin A Receptor: A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.
http://www.curehunter.com/public/keywordSummaryD043886-Cholecystokinin-A-Receptor.do
Cholecystokinin - Pancreozymin Summary Report | CureHunterCholecystokinin - Pancreozymin Summary Report | CureHunter
Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
http://www.curehunter.com/public/keywordSummaryD002766.do
Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila - ViewPointDrosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila - ViewPoint
Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) that functions at single-neuron resolution to suppress male sexual behavior in Drosophila. We found that Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for male sexual behaviors, and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spontaneous walking. We further found that the DSK-2 peptide functions through its receptor CCKLR-17D3 to suppress sexual behaviors in flies. Such a neuropeptide circuit largely overlaps with the fruitless-expressing neural circuit that governs most aspects of male sexual behaviors. Thus DSK/CCKLR signaling in the sex ...
http://viewpoint.fr/zh_CN/single/publications/drosulfakinin-signaling-in-fruitless-circuitry-antagonizes-p1-neurons-to-regulate-sexual-arousal-in-drosophila
Eating disorder - wikidocEating disorder - wikidoc
Patients with severe obsessive compulsive disorder, depression or bulimia patients were all found to have abnormally low serotonin levels.[14] Neurotransmitters such as serotonin, dopamine and norepinephrine are secreted by the intestines and central nervous system during digestion.[15] Researchers have also found low cholecystokinin levels in bulimics. Cholecystokinin is a hormone that causes one to feel full and decreases eating. Low levels of this hormone are likely to cause a lack of satiative feedback when eating, which can lead to overeating. Another explanation researchers found for overeating is abnormalities in the neuromodulator peptides, neuropeptide Y and peptide YY. Both of these peptides increase eating and work with another peptide called leptin. Leptin is released by fat cells and is known to decrease eating. Research found the majority of people who overate produced normal amounts of leptin but they might have complications with the blood-brain barrier preventing an optimal ...
http://www.wikidoc.org/index.php/Eating_disorder
Localization of cholecystokinin in the zebrafish retina from larval to adult stage.Localization of cholecystokinin in the zebrafish retina from larval to adult stage.
The peptide hormone cholecistokinin (CCK) plays a key role in the central and peripheral nervous system. It is known to be involved in the digestive physiology and in the regulation of food intake. Moreover, the CCK expression has also been detected in the retina of different vertebrates, including fish, although its biological activity in this tissue remains to be elucidated. In literature no data are yet available about the CCK-immunoreactivity in the zebrafish retina during development. Therefore, the aim of the study was to investigate the distribution of sulfated cholecystokinin octapeptide (CCK8-S) as a well preserved form during evolution in the zebrafish retina from 3days post hatching (dph) until adult stage, using immunohistochemistry in order to elucidate the potential role of this protein in the development and maintenance of normal retinal homeostasis. The cellular distribution of CCK in the retina was similar from 3 dph to 40days post fertilization (dpf) when immunoreactivity was ...
https://iris.unime.it/handle/11570/3126448
CCCC 1991, Volume 56, Issue 12, Abstracts pp. 2991-2998 | Collection of Czechoslovak Chemical CommunicationsCCCC 1991, Volume 56, Issue 12, Abstracts pp. 2991-2998 | Collection of Czechoslovak Chemical Communications
In the course of our study on cholecystokinin (CCK) a series of Boc-CCK-7 was synthesized. Their carboxyterminal part was modified by phenylalanine derivatives containing 2 or 4 and 2,6 or 2,4,6 methylated aromatic side-chain. During the synthesis, the racemic phenylalanine derivatives were used and peptides containing either L- or D- methylated phenylalanine were separated using a preparative HPLC. Gall bladder contraction, anorectic, sedative and analgetic bioassays of these analogues revealed that all of them behaved as CCK-8 agonists. While the analogues containing L-form of the methylated phenylalanines had almost the same potency (80% - 130%) in comparison to CCK-8, the presence of the D-form decreased the biological activity of corresponding analogues to 8 - 62% of the CCK-8 potency. These results are in agreement with the suggestion that phenylalanine residue in C-terminus takes part in biological activity transduction only.. ...
http://cccc.uochb.cas.cz/56/12/2991/
Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat....Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat....
Pérez de la Mora, M., Hernández-Gómez, A. M., Arizmendi-García, Y., Jacobsen, K. X., Lara-García, D., Flores-Gracia, C., Crespo-Ramírez, M., Gallegos-Cari, A., Nuche-Bricaire, A. and Fuxe, K. (2007), Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release. European Journal of Neuroscience, 26: 3614-3630. doi: 10.1111/j.1460-9568.2007.05963.x ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2007.05963.x/references
EVIDENCE THAT CHOLECYSTOKININ INDUCES IMMEDIATE-EARLY GENE-EXPRESSION IN THE BRAIN-STEM, HYPOTHALAMUS AND AMYGDALA OF THE RAT...EVIDENCE THAT CHOLECYSTOKININ INDUCES IMMEDIATE-EARLY GENE-EXPRESSION IN THE BRAIN-STEM, HYPOTHALAMUS AND AMYGDALA OF THE RAT...
EVIDENCE THAT CHOLECYSTOKININ INDUCES IMMEDIATE-EARLY GENE-EXPRESSION IN THE BRAIN-STEM, HYPOTHALAMUS AND AMYGDALA OF THE RAT BY A CCKA RECEPTOR MECHANISM Journal Article ...
https://experts.colorado.edu/display/pubid_223727
Cholecystokinin (CCK) and Relate : Severn Biotech, LimitedCholecystokinin (CCK) and Relate : Severn Biotech, Limited
Severn Biotech, Limited : Cholecystokinin (CCK) and Relate - Electrophoresis Products PBS & Saline Solutions Hybridisation Reagents Biological Buffers & SDS Sodium Azide Solutions General Bio-chemical Products Fingerprinting Chemical Product Forensic Dyes & Chemicals HPLC Laboratory Solvents DNA / RNA Extraction Specialist Pure Water Products Protein Linker Conjugates Peptide Synthesis Reagents Alcohol Sprays Hand Sanitiser Products Customised Services Comet Assay Products Protein Antibody Reagents Scientific Plastics Catalogue Peptides Affinity Purification Materials Cytology Screening Antibodies Specials severn, biotech
http://www.severnbiotech.com/index.php?main_page=index&cPath=109_186
Induction and Detection of Anti-Peptide Antibody Specificity Is Critically Affected by the Mode of Hapten Presentation. | IRIS...Induction and Detection of Anti-Peptide Antibody Specificity Is Critically Affected by the Mode of Hapten Presentation. | IRIS...
C-Terminal cholecystokinin (CCK)-peptides of increasing chain lengths were all linked at their N-termini to the single surface-exposed cysteine residue 107 of yeast iso-I-cytochrome c by the maleimide/thiol reaction. The resulting CCK/cytochrome I: I conjugates with the haptenic peptides in the identical protein environment were used to immunize outbred guinea pigs in order to assess the critical size of CCK peptides required for the expression of a CCKspecific epitope and the induction of antibodies not crossreacting with the homologous gastrin sequence. By using standard ELISA techniques with polystyrene-adsorbed antigen to evaluate the specificity of the antisera, none of the conjugates were found to induce anti-CCK antisera not crossreacting with gastrin. However, when the biotinyl-CCK-antigen was immobilized by polystyrene-adsorbed avidin, i.e. via a procedure which assures maximum accessibility of the bound antigen, we were able to demonstrate that with CCK-12 and particularly CCK-B, ...
https://flore.unifi.it/handle/2158/311569
Stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat: prevention by diazepam...Stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat: prevention by diazepam...
The in vivo release of cholecystokinin (CCK)-like material (CCKLM) was measured in the frontal cortex of freely moving rats using the microdialysis technique combined with a sensitive radioimmunoassay. Local perfusion of K+ (100 mM)-enriched artificial CSF resulted in a 10-fold increase in CCKLM outflow, as compared with that occurring under basal resting (K+ = 3.0 mM) conditions, and this effect could be completely prevented by removal of Ca2+ in the perfusing fluid. Chromatographic analyses demonstrated that CCK-8S contributed to 70% of CCKLM. Stressful stimuli such as a 2-min exposure to diethyl ether and a 30-min restraint produced a marked but transient increase in cortical CCKLM release. In addition, anxiety-like behavior induced by the systemic administration of yohimbine (5 mg/kg i.p.) was associated with a long-lasting enhancement in the peptide outflow. Pretreatment with the potent anxiolytic drug diazepam (5 mg/kg i.p., 5 min before each condition), which exerted no effect on its own,
https://www.semanticscholar.org/paper/Stress-and-yohimbine-induced-release-of-cholecysto-Nevo-Becker/7ccd9bb5bd5991288e397c1c4fe01180d1dc045f
INT287 - wiki-painINT287 - wiki-pain
Since the neuropeptide cholecystokinin (CCK) plays a role in the modulation of opiate-induced analgesia, the morphine-mediated release of CCK in the spinal cord of rats was compared with in vivo microdialysis in normals and different pain models ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php/INT287
KAKEN - Research Projects | Expression of Cholecystokinin type-A Receptor in Gallbladder with stones (KAKENHI-PROJECT-10670525)KAKEN - Research Projects | Expression of Cholecystokinin type-A Receptor in Gallbladder with stones (KAKENHI-PROJECT-10670525)
Principal Investigator：KONO Akira, Project Period (FY)：1998 - 1999, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Gastroenterology
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670525/
Produktübersicht anti-Cholecystokinin AntikörperProduktübersicht anti-Cholecystokinin Antikörper
Monoklonale und polyklonale Cholecystokinin Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für Cholecystokinin Antikörper. Hier bestellen.
http://www.antikoerper-online.de/t-zell-rezeptor-signalweg-pathway-12/cholecystokinin-antibody-8723/
Hormone synonyms | Best 29 synonyms for hormoneHormone synonyms | Best 29 synonyms for hormone
The best 29 synonyms for hormone, including: adrenaline, cholecystokinin, estrone, endocrine-gland, endocrine, internal secretion, oestrogen, leptin, gonadotropin, testosterone, progesterone and more... Find another word for hormone at YourDictionary.
https://thesaurus.yourdictionary.com/hormone
23132 bearing,23132 assembly in United States23132 bearing,23132 assembly in United States
RHP BearingsRHP Bearings List Page. Part Number, Old Bearings Number, Brand, Bearing Type, Size(ID*OD*Width) 23132CCK/W33 Bearings · 23132CC/W33 Bearings · 23130CCK/W33+H3130 Bearings · 23130CCK/W33 Bearings. ...
http://fluoridefacts.org/28784/23132-bearing%2C23132-assembly-in-United-States/
CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colonCCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon
Cholecystokinin and related peptides are involved in the control of intestinal motility and cholecystokinin receptor ligands might represent new pharmacological tools for the treatment of symptoms associated with functional bowel disorders. However, the respective roles played by cholecystokinin receptor subtypes and the mechanisms underlying these regulatory actions remain undetermined. This study was designed to examine the influence of cholecystokinin receptor subtypes on the motor activity of guinea-pig distal colon. The effects of drugs acting on CCK1 and CCK2 receptors were assessed in vitro on the contractile activity of longitudinal smooth muscle, both under basal conditions and in the presence of transmural electrical stimulation or KCl-induced contractions. The application of cholecystokinin octapeptide sulphate (cholecystokinin-8S) to colonic preparations induced concentration-dependent contractions which were prevented by devazepide (CCK1 receptor antagonist), enhanced by GV150013 ...
https://arpi.unipi.it/handle/11568/199241
Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients. | GutEffect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients. | Gut
Serum cholecystokinin (CCK) levels were measured in 10 patients with chronic duodenal ulcers, fasting and at intervals after two standard tests meals (300 ml of 40 mmol/1 phenylalanine solution), one given before and one during H2-receptor blockade with metiamide (200 mg four times a day). Fasting serum CCK levels were lower in all patients during treatment with metiamide (the mean level falling from 306-0 +/- 102-0 (SEM) to 82-1 +/- 23-6 pg/ml after treatment (p less than 0-01)). In contrast, peak serum CCK levels after the meal were not significantly different (7400 +/- 1141 pg/ml before treatment and 7569 +/- 1293 pg/ml on metiamide). We conclude that in duodenal ulcer patients CCK secretion under basal condtions may be in part dependent on stimulation of the small intestinal mucosa by gastric acid, but that, after an amino acid meal, gastric acid secretion is less important in determining the amount of CCK released.. ...
https://gut.bmj.com/content/17/11/920
Cholecystokinin test | definition of cholecystokinin test by Medical dictionaryCholecystokinin test | definition of cholecystokinin test by Medical dictionary
Looking for online definition of cholecystokinin test in the Medical Dictionary? cholecystokinin test explanation free. What is cholecystokinin test? Meaning of cholecystokinin test medical term. What does cholecystokinin test mean?
http://medical-dictionary.thefreedictionary.com/cholecystokinin+test
Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner<...Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner<...
TY - JOUR. T1 - Multiple kinases phosphorylate the pancreatic cholecystokinin receptor in an agonist-dependent manner. AU - Gates, L. K.. AU - Ulrich, C. D.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - The cholecystokinin (CCK) receptor on the rat pancreatic acinar cell is a guanine nucleotide-binding protein (G protein)-coupled receptor, which was recently demonstrated to be phosphorylated in response to agonist stimulation (Klueppelberg et al., J. Biol. Chem. 266: 17744-17746, 1991). In this work, we establish that this receptor is phosphorylated in response to a variety of homologous and heterologous secretagogues and that these phosphorylation events represent action by more than one protein kinase. One subgroup of kinases includes one or more isotype of protein kinase C (PKC), and is capable of playing a role in homologous and heterologous desensitization. A second subgroup of kinases that acts on the CCK receptor was defined by its resistance to 10 μM staurosporine, which was ...
https://mayoclinic.pure.elsevier.com/en/publications/multiple-kinases-phosphorylate-the-pancreatic-cholecystokinin-rec
Effect of intravenous C-terminal octapeptide of cholecystokinin and intraduodenal ricinoleic acid on contractile activity of...Effect of intravenous C-terminal octapeptide of cholecystokinin and intraduodenal ricinoleic acid on contractile activity of...
Intraduodenal infusion of ricinoleic acid and iv bolus injection of the C-terminal octapeptide of cholecystokinin produce markedly similar alterations in the digestive contractile patterns of the GI tract of the unanesthetized dog. The brief, initial stimulation of contractile activity in the proximal small intestine following both procedures is mediated through a cholinergic mechanism. The stimulatory response is followed by an inhibition of digestive contractile activity of unknown origin. These observations suggest that possibility that the GI hormone, cholecystokinin, may mediate the intestinal motor response evoked by infusion of ricinoleic acid directly into the proximal small intestine.
https://www.semanticscholar.org/paper/Effect-of-intravenous-C-terminal-octapeptide-of-ch-Stewart-Bass/f026438b9b7b2abf48eaa35d751cbaa9ca823c95
Plus itPlus it
The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. Evoked tritium outflow from slices of cat caudate nucleus was Ca2+ dependent and abolished by tetrodotoxin, suggesting that it reflects action potential-induced [3H]dopamine release. In the presence of bovine serum albumin and bacitracin, the sulfated but not the unsulfated form of CCK-8 inhibited both basal and electrically evoked tritium outflow from slices of cat caudate nucleus at very low concentrations. CCK-8 sulfate was efficient in causing this effect in concentrations down to 10(-14) M, and the maximum effect was obtained with 10(-11) M. In contrast, without bovine serum albumin and bacitracin, no inhibitory effect of CCK-8 ...
http://www.jneurosci.org/content/4/2/570
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell<...A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell<...
TY - JOUR. T1 - A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell. AU - Lutz, M. P.. AU - Sutor, S. L.. AU - Abraham, R. T.. AU - Miller, L. J.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - Cholecystokinin (CCK) is a gastrointestinal hormone that acts through a G protein-coupled receptor to stimulate pancreatic enzyme secretion. In this work, we demonstrate that CCK stimulation of dispersed pancreatic acini results in increased tyrosine phosphorylation of several cellular proteins. This is mediated via a calcium-dependent pathway, also activated by a phenethyl ester analogue of CCK and calcium ionophores, and by a protein kinase C-dependent cascade, also activated by the phorbol ester 12-O- tetradecanoylphorbol-13-acetate. All demonstrable stimulated tyrosine phosphorylation events were inhibited by genistein, with different subsets of proteins affected by staurosporine and H-7. The importance of tyrosine phosphorylation events in ...
https://mayoclinic.pure.elsevier.com/en/publications/a-role-for-cholecystokinin-stimulated-protein-tyrosine-phosphoryl
Modulation of hypothalamic cholecystokinin receptor density with changes in magnocellular activity: a quantitative...Modulation of hypothalamic cholecystokinin receptor density with changes in magnocellular activity: a quantitative...
A combination of autoradiographical techniques and computerized image analysis has been used to study the distribution and density of cholecystokinin receptors in the paraventricular and supraoptic nuclei of animals in which the magnocellular-posterior pituitary axis is activated, namely, in salt-lo …
https://pubmed.ncbi.nlm.nih.gov/2725863/?dopt=Abstract
Gentaur Molecular :Meridian Life Science \ Rabbit anti Cholecystokinin Receptor A \ D24010RGentaur Molecular :Meridian Life Science \ Rabbit anti Cholecystokinin Receptor A \ D24010R
Gentaur molecular products has all kinds of products like :search , Meridian Life Science \ Rabbit anti Cholecystokinin Receptor A \ D24010R for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=328580&supplier=search&name=Rabbit%20anti%20Cholecystokinin%20Receptor%20A
Cholecystokinin secretagogue-induced gastroprotection: Role of nitric oxide and blood flow<...Cholecystokinin secretagogue-induced gastroprotection: Role of nitric oxide and blood flow<...
TY - JOUR. T1 - Cholecystokinin secretagogue-induced gastroprotection. T2 - Role of nitric oxide and blood flow. AU - West, Sonlee D.. AU - Helmer, Kenneth S.. AU - Chang, Lily K.. AU - Cui, Yan. AU - Greeley, George H.. AU - Mercer, David W.. PY - 2003/3/1. Y1 - 2003/3/1. N2 - This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition (nG-nitro-L-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal ...
https://nebraska.pure.elsevier.com/en/publications/cholecystokinin-secretagogue-induced-gastroprotection-role-of-nit
Mitochondria play a critical role in shaping the exocytotic response of rat pancreatic acinar cells - UEA Digital RepositoryMitochondria play a critical role in shaping the exocytotic response of rat pancreatic acinar cells - UEA Digital Repository
We have previously demonstrated [M. Campos-Toimil, T. Bagrij, J.M. Edwardson, P. Thomas, Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca2+ entry, Curr. Biol. 12 (2002) 211-215] that in rat pancreatic acinar cells, Gd3+-sensitive Ca2+ entry is instrumental in governing which second messenger pathways control secretory activity. However, in those studies, we were unable to demonstrate a significant increase in cytoplasmic [Ca2+] during agonist application as a result of this entry pathway. In the present study, we combined pharmacology with ratiometric imaging of fura-2 fluorescence to resolve this issue. We found that 2 μM Gd3+ significantly inhibits store-mediated Ca2+ entry. Furthermore, both the protonophore, CCCP (5 μM) and the mitochondrial Ca2+-uptake blocker, RU360 (10 μM), led to an enhancement of the plateau phase of the biphasic Ca2+ response induced by acetylcholine (1 μM). This enhancement was ...
https://ueaeprints.uea.ac.uk/id/eprint/1138/
CCK-4 Acetate - Creative PeptidesCCK-4 Acetate - Creative Peptides
Cholecystokinin tetrapeptide (CCK-4, also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.
https://www.creative-peptides.com/product/cck-acetate-item-10-101-74-27.html
SIGNIFICANCE OF OCTAPEPTIDE CHOLECYSTOKININ IN DEVELOPMENT OF ODDIS SPHINCTER DYSFUNCTION OF INORGANIC ETIOLOGY AFTER...SIGNIFICANCE OF OCTAPEPTIDE CHOLECYSTOKININ IN DEVELOPMENT OF ODDIS SPHINCTER DYSFUNCTION OF INORGANIC ETIOLOGY AFTER...
SIGNIFICANCE OF OCTAPEPTIDE CHOLECYSTOKININ IN DEVELOPMENT OF ODDIS SPHINCTER DYSFUNCTION OF INORGANIC ETIOLOGY AFTER CHOLECYSTECTOMY IN PATIENTS OPERATED FOR CALCULOUS CHOLECYSTITIS
https://journals.eco-vector.com/PMJ/article/view/3309
Cholecystokinin CCK1 AequoScreen cell line | PerkinElmerCholecystokinin CCK1 AequoScreen cell line | PerkinElmer
AequoScreen® Double Transfected Cell Lines: Cholecystokinin, CCKA subtype. Human Recombinant, in 1321N1 host cell. Two vials of cryopreserved cells are shipped per order. A detailed technical dossier includes sequence, culture conditions and pharmacological properties of the recombinant receptor. All cell lines are tested for the absence of mycoplasma. Terms and conditions apply. Some products are not available in some countries. Please inquire at your local sales office for more information.. Features:. ...
http://www.perkinelmer.de/product/cholecystokinin-cck1-aequozen-es-530-af
Cholecystokinin And Secretin Uk Clinics - Menopause Villa-AgataCholecystokinin And Secretin Uk Clinics - Menopause Villa-Agata
HF in east cancer patients for up to 3 months post treatment (Hervik and.In line with international guidelines post menopausal women switch to an.reduction of HF and establishment of better sleep patterns after acupuncture dizziness palpitations and nausea leave women feeling less confident. Cholecystokinin And Secretin Uk Clinics log VVG 9192 1461 massage NN 9193 1460 liaison NN 9194 1460 utal JJ. Grand Final two interstate teams played for the first time: In an article titled Our misery is. Mood modulation with changing hormone levels.. Studies have linked hormone replacement therapy and the PAH in female mice but not in male hypoxic mice.3536. Menopause the change( of life). cModel 3 was adjusted as full model 2 + menopause.. Profasi is given after treatment with other medicines to ing about ovulation (the assisted conception techniques is higher than normal but much the same as. bladder autoaugmentation using autologous uterine flap in the rat to try and improve the the complications ...
http://www.villa-agata.eu/1607/cholecystokinin-and-secretin-uk-clinics/
Sensitivity to fat in dyspepsia | Nick ReadSensitivity to fat in dyspepsia | Nick Read
This work unlined the importance of fat in generating dyspeptic symptoms by demonstrating how duodenal infusions of fat could sensitise the stomach to distension and to motion sickness. These effects could be treated by drugs that acted on cholecystokinin, opiate and serotonin receptors ...
http://www.nickread.co.uk/research/2009/03/sensitivity-to-fat-in-dyspepsia/
OP hypertensive animals had significantly | Wnt PathwayOP hypertensive animals had significantly | Wnt Pathway
OP hypertensive animals had significantly PCI-32765 clinical trial reduced Fos-like immunoreactivity in the nucleus of the soliltary tract and the caudal ventrolateral medulla in response to CCK when compared to controls and/or OR animals, indicative of impaired signalling pathways in. the brainstem within the reflex circuit between vagal afferents and presympathetic RVLM neurons. Blunted sympathoinhibitory responses in obesity-related hypertension are associated with blunted responses in RVLM neurons as a result of aberrant central but not peripheral signalling mechanisms. The gut hormone cholecystokinin (CCK) acts at subdiaphragmatic vagal afferents to induce renal and splanchnic sympathoinhibition and vasodilatation, via reflex inhibition of a subclass of cardiovascular-controlling neurons in the rostroventrolateral medulla (RVLM). These sympathoinhibitory and vasodilator responses are blunted in obese, hypertensive rats and our aim in the present study was to determine whether this is ...
https://wnt-pathway.com/op-hypertensive-animals-had-significantly/
Context: Cholecystokinin A receptor (polymorphism is stabilized and it is more - Suppression of KRas-mutant cancer through the...Context: Cholecystokinin A receptor (polymorphism is stabilized and it is more - Suppression of KRas-mutant cancer through the...
Context: Cholecystokinin A receptor (polymorphism is stabilized and it is more consistently connected with schizophrenia within an Eastern Indian sub-population. at 95% =1.04C2.20). Bottom line: polymorphism from the gene is normally a well balanced polymorphism inside our research people. Furthermore, the C allele is normally significantly more loaded in schizophrenia sufferers imparting them a larger risk of advancement of problems like auditory hallucination. receptor (and which serves as a mediator of DA activity and escalates the discharge of DA even though performs a converse actions. Any hyper or alteration activity of results in the boosts in DA along with a consequent predisposition for schizophrenia.[10] The protein is one of the seven transmembrane receptor superfamily associated with G-protein coupled sign transduction pathway. The human gene contains five extends and exons over 21.8 kb across the 4p15 chromosome region.[11] The top features of the promoter region add a transcription ...
http://complextraitgenomics.com/context-cholecystokinin-a-receptor-polymorphism-is-stabilized-and-it-is-more/
RX Drugstore: Professional cialis all brand pills!RX Drugstore: Professional cialis all brand pills!
See also agnosia cialis professional. Situations are animals, birds, insects, heights, the icd-11 criteria for the fundamental defects in a mental state, are evidence of gut hormone cholecystokinin (cck) whereas acid in 1942 by harvard university researchers call it. Tolerance is rare. The prolonged the time of adnexectomy is worthy of specific comment, it joins the femoral bruit. This large thyroidal pool of candidate statements about an hour without a known case, the same intensity which is perpendicular to the right, and one pair of cranial nerves involved and their likelihood ratios quoted in the american hemorrhage: Prospective, modern academy of allergy, particularly of the child-bearing age excessive vaginal bleeding. Clobazam is claimed to achieve hemostatic control, as in equivalent therapeutic doses (8-30 mg orally), amphetamine produces weakness, fatiguability, twitching and mental experience. Sleep: 5-ht controls sleep-wakefulness cycle; depletion of catecholamines and 8-ht which ...
http://admissions.iuhs.edu/?page_id=professional-cialis
Not the usual suspect | Nature Reviews CancerNot the usual suspect | Nature Reviews Cancer
Chung et al. studied drivers of obesity-associated pancreatic ductal adenocarcinoma in a leptin-deficient mouse model and identified the hormone cholecystokinin, upregulated in islet beta cells in the context of obesity, to be promoting pancreatic tumorigenesis.
https://www.nature.com/articles/s41568-020-0271-0?error=cookies_not_supported&code=40c8ef1e-5782-4824-a7ec-84e38c68195f
L-365260 | CAS#118101-09-0 |CCK2 antagonist | MedKooL-365260 | CAS#118101-09-0 |CCK2 antagonist | MedKoo
L-365260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively).
http://www.medkoo.com/products/12984
Measurement of multiple forms of cholecystokinin in plasma using high pressure liquid chromatography and radioimmunoassay:...Measurement of multiple forms of cholecystokinin in plasma using high pressure liquid chromatography and radioimmunoassay:...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/1338000/
CiNii Articles - MURATA SHUNJICiNii Articles - MURATA SHUNJI
Expression of Two Different Cholecystokinin Receptors in Xenopus Oocytes Injected with mRNA from Rabbit Pancreas and Rat Hippocampus （1996 ...
https://ci.nii.ac.jp/author?q=MURATA+SHUNJI
Secretin (porcine) Hydrochloride - Creative PeptidesSecretin (porcine) Hydrochloride - Creative Peptides
Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin.
https://www.creative-peptides.com/product/secretin-porcine-hydrochloride-item-10-101-99-97.html
Intralumenal Effects on Cholesterol Absorption/Synthesis - Full Text View - ClinicalTrials.govIntralumenal Effects on Cholesterol Absorption/Synthesis - Full Text View - ClinicalTrials.gov
Cholesterol absorption plays a key role in cholesterol homeostasis and understanding the lumenal events that play key roles in absorption remain poorly understood. The aims of the present study are fourfold: 1) To determine whether previously observed effects on cholesterol absorption during bile acid feeding are related to changes in pool size and intestinal transit or meal stimulated gall bladder emptying or plasma cholecystokinin levels. 2) To determine the effect of dietary sphingomyelin on cholesterol absorption, micellar solubilization and synthesis in normal adults and to assess the effects of intralumenal cholesterol solubilization, absorption and synthesis in adults with heterozygous mdr 3 deficiency (a defect leading to low biliary phospholipid content). 3) To determine the mechanism of action of a non-ionic detergent, Pluronic F-68, by evaluating its effect on cholesterol solubilization and distribution between micelles and vesicles, on cholesterol absorption and synthesis. 4) To ...
https://clinicaltrials.gov/ct2/show/NCT00328211?term=cholesterol&rank=10
Intralumenal Effects on Cholesterol Absorption/Synthesis - Full Text View - ClinicalTrials.govIntralumenal Effects on Cholesterol Absorption/Synthesis - Full Text View - ClinicalTrials.gov
Cholesterol absorption plays a key role in cholesterol homeostasis and understanding the lumenal events that play key roles in absorption remain poorly understood. The aims of the present study are fourfold: 1) To determine whether previously observed effects on cholesterol absorption during bile acid feeding are related to changes in pool size and intestinal transit or meal stimulated gall bladder emptying or plasma cholecystokinin levels. 2) To determine the effect of dietary sphingomyelin on cholesterol absorption, micellar solubilization and synthesis in normal adults and to assess the effects of intralumenal cholesterol solubilization, absorption and synthesis in adults with heterozygous mdr 3 deficiency (a defect leading to low biliary phospholipid content). 3) To determine the mechanism of action of a non-ionic detergent, Pluronic F-68, by evaluating its effect on cholesterol solubilization and distribution between micelles and vesicles, on cholesterol absorption and synthesis. 4) To ...
https://clinicaltrials.gov/ct2/show/NCT00328211?term=cholesterol&rank=15
Cholecystokinin B receptor - WikipediaCholecystokinin B receptor - Wikipedia
CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. CCK-B expression may correlate parallel to anxiety and depression phenotypes in humans. CCK-B receptors possess a complex regulation of dopamine activity in the brain. CCK-B activation appears to possess a general inhibitory action on dopamine activity in the brain, opposing the dopamine-enhancing effects of CCK-A. However, the effects of CCK-B on dopamine activity vary depending on location.[11] CCK-B antagonism enhances dopamine release in rat striatum.[12] Activation enhances GABA release in rat anterior nucleus accumbens.[13] CCK-B receptors modulate dopamine release, and influence the development of tolerance to opioids.[14] CCK-B activation decreases amphetamine-induced DA release, and contributes to individual variability in response to amphetamine.[15] In rats, CCK-B antagonism prevents the stress-induced reactivation of cocaine-induced conditioned place preference, and ...
https://en.wikipedia.org/wiki/Cholecystokinin_B_receptor
Effect of exogenous cholecystokinin and secretin on pancreatic secretion of insulin and glucagon in rats.Effect of exogenous cholecystokinin and secretin on pancreatic secretion of insulin and glucagon in rats.
Effect of exogenous cholecystokinin and secretin on pancreatic secretion of insulin and glucagon in rats. Academic Article 2001 ...
https://research.umh.es/vivo/individual?uri=http%3A%2F%2Fresearch.umh.es%2Fvivo%2Fpub%2Farticulo%2F5444
EFFECT OF GASTROINTESTINAL HORMONES, SECRETIN AND CHOLECYSTOKININ-PANCREOZYMIN, ON INSULIN AND GLUCAGON RELEASE IN HEALTHY AND...EFFECT OF GASTROINTESTINAL HORMONES, SECRETIN AND CHOLECYSTOKININ-PANCREOZYMIN, ON INSULIN AND GLUCAGON RELEASE IN HEALTHY AND...
EFFECT OF GASTROINTESTINAL HORMONES, SECRETIN AND CHOLECYSTOKININ-PANCREOZYMIN, ON INSULIN AND GLUCAGON RELEASE IN HEALTHY AND DIABETIC ...
https://oparu.uni-ulm.de/xmlui/handle/123456789/10235
Delayed postprandial plasma bile acid response in coeliac patients with slow mouth-caecum transit | Clinical Science | Portland...Delayed postprandial plasma bile acid response in coeliac patients with slow mouth-caecum transit | Clinical Science | Portland...
1. Coeliac patients are known to have an expanded bile salt pool which recirculates slowly due, at least in part, to impaired gall bladder contractility. We have investigated the possibility that delayed small bowel transit of chyme and bile may also contribute to this sluggish recycling.. 2. Plasma cholylglycine, total bile acids and cholecystokinin concentrations were measured after a lactulose-labelled test meal whose mouth-caecum transit time (M-C TT) was assessed by the breath hydrogen technique.. 3. Overall there were no significant differences in plasma bile acid profiles between seven healthy controls and a group of 25 coeliac patients. However, when subjects were divided according to their M-C TT, the 10 with the slowest transit were found to have significant elevation of fasting levels when compared with the 10 with the fastest transit, fasting total bile acids being 3.4 ± 1.3 versus 0.7 ± 0.6 μmol/l (P , 0.02) and fasting cholylglycine being 0.43 ± 0.17 versus 0.06 ± 0.04 μmol/l ...
https://portlandpress.com/clinsci/article-abstract/72/2/217/74138/Delayed-postprandial-plasma-bile-acid-response-in
Role of cholecystokinin (CCK)-A receptor for pancreatic growth after weaning: a study in a new rat model without gene...Role of cholecystokinin (CCK)-A receptor for pancreatic growth after weaning: a study in a new rat model without gene...
This work extends a recent observation that Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of non-insulin-dependent diabetes mellitus, show no expression of the cholecystokinin (CCK)-A receptor gene in the pancreas. The CCK-A receptor is known to be in...
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART00001743
Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive...Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive...
To investigate the electrophysiological properties, synaptic connections, and anatomy of individual parvalbumin-immunoreactive (PV-IR) and cholecystokinin-immunoreactive (CCK-IR) interneurones in CA1, dual intracellular recordings using biocytin-filled microelectrodes in slices of adult rat hippocampus were combined with fluorescence labelling of PV- and CCK-containing cells. Of 36 PV-IR cells, 29 were basket cells, with most of their axonal arbours in the stratum pyramidale (SP). Six were bistratified cells with axons ramifying throughout stratum oriens (SO) and stratum radiatum (SR). One was a putative axo-axonic cell with an axonal arbour confined to half of the SP and a narrow adjacent region of the SO. Of 27 CCK-IR neurones, 13 were basket cells, with most of their axonal arbours in the SP, and included basket cells with somata in the SP (6), SO (3), and SR (2) and at the border between the stratum lacunosum-moleculare (SLM) and the SR (2). In addition, several dendrite-targeting cell ...
http://eprints.gla.ac.uk/59278/
Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in...Role of endogenous secretin and cholecystokinin in intraduodenal oleic acid-induced inhibition of gastric acid secretion in...
We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats. Intraduodenal ad
https://link.springer.com/article/10.1007%2FBF01307734
CCK-4 - WikipediaCCK-4 - Wikipedia
Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointestinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58. CCK-4 reliably causes severe anxiety symptoms when administered to humans in a dose of as little as 50μg,[1] and is commonly used in scientific research to induce panic attacks for the purpose of testing new anxiolytic drugs.[2][3][4][5] Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a short duration of action,[6] although numerous synthetic analogues with modified properties are known.[7][8][9][10][11][12][13][14][15][16][17] ...
https://en.wikipedia.org/wiki/CCK-4
Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the...Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the...
Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown. Using patch clamp recording, western blot analysis, immunofluorescent labelling, enzyme-linked immunosorbent assays, adenovirus-mediated shRNA knockdown and animal behaviour tests, we studied the effects of CCK-8 on the sensory neuronal excitability and peripheral pain sensitivity mediated by A-type K+ channels. CCK-8 reversibly and concentration-dependently decreased A-type K+ channel (IA) in small-sized dorsal root ganglion (DRG) neurons through the activation of CCK type B receptor (CCK-BR), while the sustained delayed rectifier K+ current was unaffected. The intracellular subunit of CCK-BR coimmunoprecipitated with Gαo. Blocking G-protein signaling with pertussis toxin or by the intracellular application of anti-Gβ antibody reversed the inhibitory effects of CCK-8. Antagonism of phosphatidylinositol 3-kinase
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0385-8
DeCS Ingl s+escopoDeCS Ingl s+escopo
Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood. . ...
http://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Receptors,%20Cholinergic
Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. -...Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. -...
In the hippocampal CA1 area, a relatively homogenous population of pyramidal cells is accompanied by a diversity of GABAergic interneurons. Previously, we found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum moleculare cells, innervating different domains of pyramidal cells, have distinct firing patterns during network oscillations in vivo. A second family of interneurons, expressing cholecystokinin but not parvalbumin, is known to target the same domains of pyramidal cells as do the parvalbumin cells. To test the temporal activity of these independent and parallel GABAergic inputs, we recorded the precise spike timing of identified cholecystokinin interneurons during hippocampal network oscillations in anesthetized rats and determined their molecular expression profiles and synaptic targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing basket and dendrite
https://pharm.ox.ac.uk/publications/329287
Health Benefits Of LiverHealth Benefits Of Liver
high-fiber and gas-producing bile from the gallbladder. Gall bladder surgical interventional endoscopist. It can be detected gallbladder foods with protein using gallbladder means that they will suggests that could be that has characteristic symptom of gallbladder is an internal organs. Gallbladder attack is connected to a natural treatment of Gallbladder means that patients usually join together within a few people. Even in appalling circumstances to ask for the digestive tract, which may also wish to try. The primary function of the hormone cholecystokinin causes the gallbladder stones. Yes and treatment option, its a reminder the liver cells. Trim health benefits of liver the fat contact some complicated gallbladder, gall bladder infection signs can be seen on taking deep breaths. The side effectively removes gallbladder pain after surgery zoloft gallstones may develops with duct or if you are scheduled to accept their gallbladder problems. If the cancer of the best way to ensure that the ...
http://healthygallbladder.com/554159/health-benefits-of-liver/
Digestion - WikiEducatorDigestion - WikiEducator
The liver produces bile which is stored in the gall bladder. It then flows down through the bile duct into the duodenum. It is a green liquid, a mixture of substances not all of which are involved in the digestion. The digestion components are inorganic components of sodium. These salts emulsify lipids by lowering their surface tension causing them to break up into numerous droplets there by increasing their surface area for enzyme action. The secretion of bile is controlled by a hormone CHOLECYSTOKININ, while its production in the liver is controlled by the hormone Secretin. Bile is also rich in sodium bicarbonate, which neutralizes the acid from the stomach. The PH of the small intestines is therefore alkaline, which favors the action of the various enzymes. The hormones secretin also stimulates the pancreas to release pancreatic juice into the duodenum via the pancreatic duct. Pancreatic juice contains three enzymes. ...
https://wikieducator.org/Digestion
AopwikiAopwiki
1. Adler G: Regulation of human pancreatic secretion. Digestion 58 Suppl 1:39-41,1997. 2. Berg JM, Tymoczko JL, Stryer L: Many enzymes are activated by specific proteolytic cleavage. Biochemistry. 5th edition. New York: W H Freeman, Section 10.5,2002. 3. Bourassa J, Laine J, Kruse ML, Gagnon MC, Calvo E, Morisset J: Ontogeny and species differences in the pancreatic expression and localization of the CCK(A) receptors. Biochem Biophys Res Commun 260:820-828,1999. 4. Chandra R, Liddle RA: Neural and hormonal regulation of pancreatic secretion. Curr Opin Gastroenterol 25:441-446,2009. 5. Dufresne M, Seva C, Fourmy D: Cholecystokinin and gastrin receptors. Physiol Rev 86:805-847,2006. 6. Folsch UR, Winckler K, Wormsley KG: Influence of repeated administration of cholecystokinin and secretin on the pancreas of the rat. Scand J Gastroenterol 13:663-671,1978. 7. Geron E, Schejter ED, Shilo BZ: Assessing the secretory capacity of pancreatic acinar cells. J Vis Exp,2014. 8. Goke B, Printz H, Koop I, ...
https://aopwiki.org/events/1723
Effect of hypergastrinemia and blockade of gastrin-receptors on pancreatic growth in the mouseEffect of hypergastrinemia and blockade of gastrin-receptors on pancreatic growth in the mouse
The present results strongly suggest that endogenous gastrin--in contrast to CCK--does not regulate pancreatic growth in the mouse. The inhibitory effect of loxiglumide on omeprazole-induced increase in serum gastrin might be explained by recent findings which showed that CCK-A antagonists can stimu …
https://pubmed.ncbi.nlm.nih.gov/8586382/
Plus itPlus it
The accompanying paper (Bignon et al., 1999) on SR146131 describes the compounds effects as a potent and selective agonist at both human and rodent CCK1 receptors in vitro. The present paper evaluated the drugs effects in vivo, and shows clearly that SR146131 can mimic, in a variety of test systems and in several species, a wide range of the effects of sulfated cholecystokinin octapeptide (CCK8S), which have previously been attributed to the stimulation of CCK1 receptors but not those related to the stimulation of CCK2 receptors.. SR146131 inhibited gastric emptying in mice, and also decreased gallbladder volume in this species after administration of low oral doses. SR146131 also reduced food intake in two rodent and one primate species. The compound reduced food intake in fasted rats, and in nonfasted rats in which food intake had been highly stimulated by the administration of NPY(1-36). Food intake was also reduced by oral administration of SR146131 in fasted gerbils, and in marmosets ...
http://jpet.aspetjournals.org/content/289/2/752
Get PDF - Symposium on gastrointestinal hormones. A clinical study of regulation of motility of digestive tract by...Get PDF - Symposium on gastrointestinal hormones. A clinical study of regulation of motility of digestive tract by...
Ishikawa, M.; Ishimori, A., 1974: Symposium on gastrointestinal hormones. A clinical study of regulation of motility of digestive tract by gastrointestinal hormones
https://eurekamag.com/research/044/497/044497111.php
Nutrition Chicago, Diet Hinsdale, Healthy Eating Merrillsville, INNutrition Chicago, Diet Hinsdale, Healthy Eating Merrillsville, IN
The Rationalle the ShapeMedUSA Diet program is as follows:. 1. Eggs. Skip the bagel this morning. Eggs, which are full of protein, will help you feel fuller longer-a lot longer. A multicenter study of 30 overweight or obese women found that those who ate two scrambled eggs (with two slices of toast and a reduced-calorie fruit spread) consumed less for the next 36 hours than women who had a bagel breakfast of equal calories. Other research has shown that protein may also prevent spikes in blood sugar, which can lead to food cravings.. 2. Beans. Youve probably never heard of cholecystokinin, but its one of your best weight-loss pals. This digestive hormone is a natural appetite suppressant. So how do you get more cholecystokinin? One way, report researchers at the University of California at Davis, is by eating beans: A study of eight men found that their levels of the hormone (which may work by keeping food in your stomach longer) were twice as high after a meal containing beans than after a ...
http://shapemed4u.com/nutrition.html
Plus itPlus it
Steve Bloom (London, U.K.) discussed satiety signals, noting that obesity is key to the [insulin resistance] syndrome and that it ultimately is caused by overeating. Childhood obesity is on the rise, with 40% of children expected to be overweight by 2010. He asked, what explains the reduction in hunger after a meal? Bulk in the stomach and nutrients in the circulation appear not to be the cause. There must be specific signals from the gut to the brain, neural and/or hormonal. It appears that, when stimulated, a small area in the proximal gastric fundus, near the esophagus, sends vagal signals mediating satiety. Studies have attempted to replicate gut hormonal signals by infusion, with cholecystokinin (CCK) decreasing food intake but causing pancreatitis and acting as a growth factor for pancreatic acinar cells, which could cause increased pancreatic cancer risk. Ghrelin decreases after meals and may be a negative satiety signal, as its direct effect is to stimulate food intake. Pancreatic ...
http://care.diabetesjournals.org/content/30/7/1934
JCI - WelcomeJCI - Welcome
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being electrically excitable, enteroendocrine cells are generally thought to communicate indirectly with nerves through hormone secretion and not through direct cell-nerve contact. However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we named neuropod. Here, we determined that neuropods provide a direct connection between enteroendocrine cells and neurons innervating the small intestine and colon. Using cell-specific transgenic mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for neurotransmission, including expression of genes that encode pre-, post-, and transsynaptic proteins. This neuroepithelial circuit was reconstituted in vitro by coculturing single enteroendocrine cells with sensory ...
https://www.jci.org/posts/243
JCI - WelcomeJCI - Welcome
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being electrically excitable, enteroendocrine cells are generally thought to communicate indirectly with nerves through hormone secretion and not through direct cell-nerve contact. However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we named neuropod. Here, we determined that neuropods provide a direct connection between enteroendocrine cells and neurons innervating the small intestine and colon. Using cell-specific transgenic mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for neurotransmission, including expression of genes that encode pre-, post-, and transsynaptic proteins. This neuroepithelial circuit was reconstituted in vitro by coculturing single enteroendocrine cells with sensory ...
https://lq101.com.www.mobile.jci.org/posts/243
INT6856 - wiki-painINT6856 - wiki-pain
We employed dual probe microdialysis in the nucleus accumbens and ipsilateral ventral pallidum of the halothane anaesthetized rat to investigate the effect of intra-accumbens perfusion with the sulphated octapeptide cholecystokinin (CCK-8S, 10-1000 nM, 60 min) alone and in the presence of the selective CCK1 and CCK2 receptor antagonists L-364,718 (10 and 100 nM) and PD134308 (10 nM), tetrodotoxin (TTX, 1000 nM) and the GABA(A) receptor antagonist bicuculline (1000 nM), on dialysate GABA levels in the ventral pallidum ...
http://gnteam.cs.manchester.ac.uk/demos/wiki-pain/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=INT6856&printable=yes
Analysis on difference in gastrointestinal hormone levels of patients with the history of diabetes and concurrent nephropathy...Analysis on difference in gastrointestinal hormone levels of patients with the history of diabetes and concurrent nephropathy...
OBJECTIVE: To compare the difference in the gastrointestinal hormone levels of the patients with the history of diabetes and concurrent nephropathy and inv
http://www.europeanreview.org/article/13225
Sphincter of Oddi | OddiSphincter of Oddi | Oddi
As previously mentioned, the sphincter of Oddi is tonically closed when there is no intake of food. As soon as the upper gastro intestinal tract begins digestion and especially when fat and amino acids reach the duodenum 30 minutes after a meal, cholecystokinin enters the blood stream from the duodenal mucosa. This would then stimulate the gallbladder to empty its contents, bile, through rhythmical contractions of its wall. The same hormone would also stimulate increased secretions of digestive enzymes from the pancreas. However, effective emptying would not be completed without CCK decreasing the resistance of the sphincter of Oddi and simultaneously releasing bile and digestive enzymes into the duodenum.. ...
http://oddi.net/sphincter-of-oddi/
Plus itPlus it
3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic membranes. The radioligand recognized a single class of binding sites with a high affinity (Kd = 0.23 nM). The binding of [3H]-(+/-)-L-364,718 was stereospecific in that the more biologically active (-)-enantiomer demonstrated greater potency than the (+)-enantiomer. The rank order of potency of various CCK agonists and antagonists in displacing [3H]-(+/-)-L-364,718 correlated with their ability to displace [125I]CCK-8 and their known pharmacological activities in peripheral tissues. However, the absolute potencies of agonists were greater in displacing [125I]CCK-8 than [3H]-(+/-)-L-364,718. As described for other physiologically relevant receptor systems, the potency for displacement of [3H]-(+/-)-L-364,718 binding by CCK agonists, but not antagonists, was reduced by guanosine 5-(beta, gamma-imido)triphosphate and NaCl and enhanced by MgCl2. ...
http://molpharm.aspetjournals.org/content/30/3/212
Pharmacological potential of novel agonists for FFAR4 on islet and enteroendocrine cell function and glucose homeostasis -...Pharmacological potential of novel agonists for FFAR4 on islet and enteroendocrine cell function and glucose homeostasis -...
Fingerprint Dive into the research topics of Pharmacological potential of novel agonists for FFAR4 on islet and enteroendocrine cell function and glucose homeostasis. Together they form a unique fingerprint. ...
https://pure.ulster.ac.uk/en/publications/pharmacological-potential-of-novel-agonists-for-ffar4-on-islet-an/fingerprints/
CCKBR Gene - GeneCards | GASR Protein | GASR AntibodyCCKBR Gene - GeneCards | GASR Protein | GASR Antibody
Complete information for CCKBR gene (Protein Coding), Cholecystokinin B Receptor, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCKBR&keywords=GH11J006258&prefilter=genomic_location
Gastrointestinal HormoneGastrointestinal Hormone
1997-2006 Healthboard.com. Healthboard.com is a purely informational website, and should not be used as a substitute for professional legal, medical or technical advice. ...
http://healthboard.com/Encyclopedia/Biotech/term/gastrointestinal_hormone.html
CCK-4 - ВикипедијаCCK-4 - Википедија
Y , StdInChIKey = , bioavailability = 100% , protein_bound = , metabolism = proteaze plazme , elimination_half-life = 13 minuta , excretion = N/A , pregnancy_AU = , pregnancy_US = , pregnancy_category= , legal_AU = , legal_CA = , legal_UK = , legal_US = , legal_status = , routes_of_administration = IV }} CCK-4 (holecistokininski tetrapeptid, Trp-Met-Asp-Phe-NH2; ili PTK7) je peptidni fragment izveden iz većeg peptidnog hormona holecistokinina. Za razliku od holecistokina koji ima niz uloga u gastrointestinalnom sistemu kao i u centralnom nervnom sistemu, CCK-4 deluje prvenstveno u mozgu kao stimulator anksioznosti. On pokazuje slabe GI efekte, za razliku od CCK-8 ili polipeptida pune dužine, CCK-58. CCK-4 proizvodi jake simptome anksioznosti u malim dozama, kao što je 50 μg,[1] i često se koristi u naučnim istraživanjima za indukovanje paničnih napada s ciljem testiranja novih anksiolitika.[2][3][4][5] Pošto je on peptid, CCK-4 mora biti administriran putem injekcije. U telu se brzo ...
https://sr.wikipedia.org/wiki/CCK-4
liquid testliquid test
{% for product in collections[featured].products %} {% include bold-product with product, hide_action: skip %} {{product.id}}, {% endfor %}
https://healthcare-manager.com/pages/liquid-test
SKF 22213cck/W33/C3 Spherical Roller Bearing 22213ck, 22213K, 22213ek, 22213 Cck, Ck, Ek | 22213cck/W33/C3 BearingSKF 22213cck/W33/C3 Spherical Roller Bearing 22213ck, 22213K, 22213ek, 22213 Cck, Ck, Ek | 22213cck/W33/C3 Bearing
Enjoy High Margins ASAHI FORGE OF AMERICA BEARING CORP. on Competitive 22211 EK Bearing Pricing.Great 1.25 Inch | 31.75 Mi Bolt Spacing Wholesale Products at Low Costs.
https://pufidikcanavarlar.com/skf-22213cck-w33-c3-bearing/
SR 27897 | CCK1 antagonist | Lintitript | SR27897 | CAS [136381-85-6] | Axon 1245 | Axon Ligand™ with |99% purity available...SR 27897 | CCK1 antagonist | Lintitript | SR27897 | CAS [136381-85-6] | Axon 1245 | Axon Ligand™ with |99% purity available...
SR 27897 | CCK1 antagonist | Lintitript | SR27897 | CAS [136381-85-6] | Axon 1245 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research
https://www.axonmedchem.com/product/1245
Parasympathetic nervous systemParasympathetic nervous system
Wank, SA (Nov 1995). "Cholecystokinin receptors". The American Journal of Physiology. 269 (5 Pt 1): G628-46. doi:10.1152/ajpgi. ... Takai, N; Shida, T; Uchihashi, K; Ueda, Y; Yoshida, Y (Apr 15, 1998). "Cholecystokinin as neurotransmitter and neuromodulator ... such as cholecystokinin) can be used. The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic ...
https://en.wikipedia.org/wiki/Parasympathetic_nervous_system
Sphincter of OddiSphincter of Oddi
The sphincter of Oddi is relaxed by the hormone cholecystokinin via vasoactive intestinal peptide. Opiates may cause spasms of ... Liddle, Rodger A. (2003-01-01). "CCK (Cholecystokinin)". Encyclopedia of Endocrine Diseases: 485-489. doi:10.1016/B0-12-475570- ... 4/00260-2. Wiley JW, O'Dorisio TM, Owyang C (June 1988). "Vasoactive intestinal polypeptide mediates cholecystokinin-induced ...
https://en.wikipedia.org/wiki/Sphincter_of_Oddi
BradykininBradykinin
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Bradykinin
Insulin-like growth factor 2Insulin-like growth factor 2
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Insulin-like_growth_factor_2
Glucagon-like peptide-2Glucagon-like peptide-2
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Glucagon-like_peptide_2
CCK-4CCK-4
Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2) is a peptide fragment derived from the larger peptide hormone ... Anokhina IP, Proskuriakova TV, Bespalova ZhD, Pal'keeva ME, Shokhonova VA, Petrichenko OB (2006). "[Effect of a cholecystokinin ... Koulischer D, Moroder L, Deschodt-Lanckman M (August 1982). "Degradation of cholecystokinin octapeptide, related fragments and ... 2005). "Panic Induction with Cholecystokinin-Tetrapeptide (CCK-4) Increases Plasma Concentrations of the Neuroactive Steroid 3α ...
https://en.wikipedia.org/wiki/CCK-4
Galanin receptor 1Galanin receptor 1
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Galanin_receptor_1
Neuromedin NNeuromedin N
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Neuromedin_N
Placental lactogenPlacental lactogen
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Placental_lactogen
Pancreatic polypeptidePancreatic polypeptide
It is the antagonist of cholecystokinin and opposes pancreatic secretion stimulated by cholecystokinin.[3] It may stimulate the ... The excitation of the vagus nerve, the administration of gastrin, secretin or cholecystokinin induce PP secretion. ...
https://en.wikipedia.org/wiki/Pancreatic_polypeptide
StomachStomach
Cholecystokinin. Cholecystokinin (CCK) has most effect on the gall bladder, causing gall bladder contractions, but it also ...
https://en.wikipedia.org/wiki/Stomach
OrexinOrexin
"Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... cholecystokinin A receptors,[47] and catecholamines,[48][49] as well as to ghrelin, leptin, and glucose.[50] Orexinergic ...
https://en.wikipedia.org/wiki/Orexin
Corticotropin-releasing hormone receptor 2Corticotropin-releasing hormone receptor 2
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Corticotropin-releasing_hormone_receptor_2
Gonadotropin preparationsGonadotropin preparations
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Gonadotropin_Preparations
Parathyroid hormone-related proteinParathyroid hormone-related protein
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein
Ethylenediaminetetraacetic acidEthylenediaminetetraacetic acid
Cholecystokinin. CCKA. *Agonists: Cholecystokinin. *Antagonists: Amiglumide. *Asperlicin. *Devazepide. *Dexloxiglumide. * ...
https://en.wikipedia.org/wiki/Edta
NeurotransmitterNeurotransmitter
Cholecystokinin B receptor. -. PP: Gastrins. Cholecystokinin. CCK. Cholecystokinin receptors. -. PP: Neurohypophyseals. ...
https://en.wikipedia.org/wiki/Neuro_transmitter
SomatostatinomaSomatostatinoma
... steatorrhoea by inhibiting cholecystokinin and secretin, gall stones by inhibiting cholecystokinin which normally induce ... due to inhibition of cholecystokinin release), and achlorhydria (due to inhibition of gastrin release). Somatostatinomas are ...
https://en.wikipedia.org/wiki/Somatostatinoma
Gastrin familyGastrin family
... of proteins is defined by the peptide hormones gastrin and cholecystokinin. Gastrin and cholecystokinin (CCK) are structurally ... Watson S, Arkinstall S (1994). "Cholecystokinin (CCK) and gastrin". The G-protein linked receptor factsbook. London: Academic ... CCK; GAST; Baldwin GS, Patel O, Shulkes A (February 2010). "Evolution of gastrointestinal hormones: the cholecystokinin/gastrin ... The gastrin family (also known as the gastrin/cholecystokinin family) ...
https://en.wikipedia.org/wiki/Gastrin_family
SatiationSatiation
See also Cholecystokinin-mediated satiety. Economic satiation, where increasing the amount of a good reduces the worth of each ...
https://en.wikipedia.org/wiki/Satiation
Erik JorpesErik Jorpes
ISBN 978-981-31446-3-7. Jorpes, Johan Erik; Mutt, Viktor (1973). Secretin, Cholecystokinin, Pancreozymin and Gastrin. Berlin: ...
https://en.wikipedia.org/wiki/Erik_Jorpes
LorglumideLorglumide
de Tullio P, Delarge J, Pirotte B (June 1999). "Recent advances in the chemistry of cholecystokinin receptor ligands (agonists ... Berna MJ, Tapia JA, Sancho V, Jensen RT (December 2007). "Progress in developing cholecystokinin (CCK)/gastrin receptor ligands ... de Tullio P, Delarge J, Pirotte B (January 2000). "Therapeutic and chemical developments of cholecystokinin receptor ligands". ... November 1987). "Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists". ...
https://en.wikipedia.org/wiki/Lorglumide
Local hormoneLocal hormone
Gastrin Cholecystokinin (CCK) The Secretin family are peptides that act as local hormones which regulate activity of G-protein ... Jens F. Rehfeld; Lennart Friis-Hansen; Jens P. Goetze; Thomas V. O. Hansen (2007-06-01). "The Biology of Cholecystokinin and ... 2007). "The biology of cholecystokinin and gastrin peptides". Curr Top Med Chem. 2007;7(12):1154-65. 9. Henriksen JH, de ...
https://en.wikipedia.org/wiki/Local_hormone
AntianalgesiaAntianalgesia
... is the ability of some endogenous chemicals (notably cholecystokinin and neuropeptide Y) to counter the effects ... Wiertelak, EP; Maier, SF; Watkins, LR (8 May 1992). "Cholecystokinin antianalgesia: safety cues abolish morphine analgesia" ( ...
https://en.wikipedia.org/wiki/Antianalgesia
Gastric acidGastric acid
... cholecystokinin, and secretin all inhibit production. The production of gastric acid in the stomach is tightly regulated by ...
https://en.wikipedia.org/wiki/Gastric_acid
CeruletideCeruletide
... is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; ...
https://en.wikipedia.org/wiki/Ceruletide
Gastrocolic reflexGastrocolic reflex
These include serotonin, neurotensin, cholecystokinin, prostaglandin E1, and gastrin. Clinically, the gastrocolic reflex has ... Disturbed motilin and cholecystokinin release in the irritable bowel syndrome in Scand J Gastroenterol, 31:11, pp 1110-4, PMID ...
https://en.wikipedia.org/wiki/Gastrocolic_reflex
EnterogastroneEnterogastrone
Examples include: Secretin Cholecystokinin You C, Chey W (1987). "Secretin is an enterogastrone in humans". Dig Dis Sci. 32 (5 ... Lloyd K, Maxwell V, Chuang C, Wong H, Soll A, Walsh J (1994). "Somatostatin is released in response to cholecystokinin by ...
https://en.wikipedia.org/wiki/Enterogastrone
Tripeptidyl peptidase IITripeptidyl peptidase II
2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of ... 1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature. 380 (6573): 403-9. doi: ...
https://en.wikipedia.org/wiki/Tripeptidyl_peptidase_II
Cholecystokinin B receptor - WikipediaCholecystokinin B receptor - Wikipedia
Wang J, Si YM, Liu ZL, Yu L (Jun 2003). "Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene ... type B gastrin/cholecystokinin receptor binding. • gastrin receptor activity. • cholecystokinin receptor activity. • peptide ... The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein[5] that in humans is encoded by the CCKBR gene.[6] ... "Entrez Gene: CCKBR cholecystokinin B receptor".. *^ Altar CA, Boyar WC (Apr 1989). "Brain CCK-B receptors mediate the ...
https://en.wikipedia.org/wiki/Cholecystokinin_B_receptor
Cholecystokinin | hormone | BritannicaCholecystokinin | hormone | Britannica
Cholecystokinin and pancreozymin were once considered two separate hormones because two distinct actions had been described: ... Cholecystokinin (CCK), a digestive hormone released with secretin when food from the stomach reaches the first part of the ... human digestive system: Cholecystokinin. Cholecystokinin, a peptide secreted by the I cells in response to the emptying of the ... human digestive system: Cholecystokinin. Cholecystokinin, a peptide secreted by the I cells in response to the emptying of the ...
https://www.britannica.com/science/cholecystokinin
Cholecystokinin-1 Receptor | SpringerLinkCholecystokinin-1 Receptor | SpringerLink
CCK(A) receptor; CCK1; CCK-A receptor; CCKA; CCKAR; CCK-AR; Cholecystokinin receptor 1; Cholecystokinin type A receptor; CCK-1 ... CCK(A) receptor; CCK1; CCK-A receptor; CCKA; CCKAR; CCK-AR; Cholecystokinin receptor 1; Cholecystokinin type A receptor; CCK-1 ... Miller L.J. (2018) Cholecystokinin-1 Receptor. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS ... Agonist-regulated phosphorylation of the pancreatic cholecystokinin receptor. J Biol Chem. 1991;266:2403-8.PubMedPubMedCentral ...
https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_273
Cholecystokinin - WikipediaCholecystokinin - Wikipedia
Media related to Cholecystokinin at Wikimedia Commons Cholecystokinin at the US National Library of Medicine Medical Subject ... "Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor". The Journal of Neuroscience. 25 ( ... Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) ... It is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to gastrin, another ...
https://en.wikipedia.org/wiki/Cholecystokinin
Cholecystokinin-dopamine interactionsCholecystokinin-dopamine interactions
Cholecystokinin (CCK) coexists with dopamine in a large proportion of the ventral tegmental and substantia nigra neurons in ... Cholecystokinin-dopamine interactions Trends Pharmacol Sci. 1991 Jun;12(6):232-6. doi: 10.1016/0165-6147(91)90558-a. ... Cholecystokinin (CCK) coexists with dopamine in a large proportion of the ventral tegmental and substantia nigra neurons in ...
https://pubmed.ncbi.nlm.nih.gov/2048219/?dopt=Abstract
Cholecystokinin receptor - WikipediaCholecystokinin receptor - Wikipedia
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews. 51 (4): 745-81. PMID 10581329.. ... Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805-47. doi:10.1152/physrev ... Cholecystokinin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) ...
http://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FCholecystokinin_receptor
Cholecystokinin - MeSH - NCBICholecystokinin - MeSH - NCBI
Cholecystokinin. A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central ... All MeSH CategoriesChemicals and Drugs CategoryAmino Acids, Peptides, and ProteinsPeptidesCholecystokininSincalide ... Cholecystokinin may be the mediator of satiety.. Year introduced: PANCREOZYMIN was heading 1963-1976 (Prov 1963-1966), was see ... and Hormone AntagonistsHormonesGastrointestinal HormonesCholecystokininSincalide ...
https://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term=%22Cholecystokinin%22%5BMeSH+Terms%5D
Cholecystokinin receptor - WikipediaCholecystokinin receptor - Wikipedia
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones ... Cholecystokinin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ... Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805-47. doi:10.1152/physrev ... There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been ...
https://en.wikipedia.org/wiki/Cholecystokinin_receptor
Gastrin/cholecystokinin peptide hormone (IPR001651) | InterPro | EMBL-EBIGastrin/cholecystokinin peptide hormone (IPR001651) | InterPro | EMBL-EBI
Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal ... gastrin/cholecystokinin-like peptide and cionin, a neuropeptide from the protochordate Ciona intestinalis belong to the same ...
http://www.ebi.ac.uk/interpro/entry/IPR001651
Cholecystokinin receptor type A (IPR000596) | InterPro | EMBL-EBICholecystokinin receptor type A (IPR000596) | InterPro | EMBL-EBI
Cholecystokinin receptor type A (IPR000596). Short name: Cholcy_rcpt_A Overlapping homologous superfamilies *Cholecystokinin A ... Cholecystokinins (CCKs) and gastrins are naturally-occurring peptides that share a common C-terminal sequence, GWMDF; full ...
http://www.ebi.ac.uk/interpro/entry/IPR000596
Cholecystokinin (Injection Route) Description and Brand Names - Mayo ClinicCholecystokinin (Injection Route) Description and Brand Names - Mayo Clinic
The doses of cholecystokinin will be different for different patients and depend on the weight of the patient and on the type ... Cholecystokinin is given by injection before tests are done to see if the gallbladder and pancreas are working the way they ... Cholecystokinin belongs to the group of medicines known as diagnostic aids. Diagnostic aids are used to help diagnose certain ... In addition, cholecystokinin increases the movements or contractions of the stomach and intestines. The doctor will know if ...
https://www.mayoclinic.org/drugs-supplements/cholecystokinin-injection-route/description/drg-20062785
cholecystokinin ELISA Kits | Biocompare.comcholecystokinin ELISA Kits | Biocompare.com
Compare cholecystokinin ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... cholecystokinin ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ...
https://www.biocompare.com/pfu/110627/soids/2-322947/ELISA_Kit/ELISA_cholecystokinin
Recombinant Human Cholecystokinin protein (ab158040) | AbcamRecombinant Human Cholecystokinin protein (ab158040) | Abcam
Buy our Recombinant Human Cholecystokinin protein. Ab158040 is a full length protein produced in Wheat germ and has been ... Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the ... The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. ...
https://www.abcam.com/recombinant-human-cholecystokinin-protein-ab158040.html
Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. - PubMed - NCBIImmunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. - PubMed - NCBI
Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala.. Mascagni F1, ... In the present study, immunohistochemical techniques were used to analyze neurons in the rat ABL that contain cholecystokinin ( ...
https://www.ncbi.nlm.nih.gov/pubmed/12763251?dopt=Abstract
Species specificity of cholecystokinin in gut and brain of several mammalian species | PNASSpecies specificity of cholecystokinin in gut and brain of several mammalian species | PNAS
Species specificity of cholecystokinin in gut and brain of several mammalian species. E Straus and R S Yalow ... Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the ... The amount of cholecystokinin in the brain is comparable to that found in the gastrointestinal tract, the traditional site for ... The failure to detect intact cholecystokinin in extracts from monkey or dog by using an antiserum developed by immunization ...
https://www.pnas.org/content/75/1/486
Cholecystokinin | Hormone Health NetworkCholecystokinin | Hormone Health Network
Hormone Health Network is here to answer all your questions about what cholecystokinin is and what it does. Learn more at ... What is Cholecystokinin?. Cholecystokinin, otherwise known as CCK or CCK-PZ, is a hormone that was once called pancreozymin ... Individuals who have cholecystokinin levels that are too high suffer no known ill effects. In fact, the lack of cholecystokinin ... How Does cholecystokinin work?. Cholecystokinins most recognized function is its ability to improve digestion. The hormone ...
https://www.hormone.org/hormone/hormones-and-health/hormones/cholecystokinin
Cholecystokinin Antibodies: Novus BiologicalsCholecystokinin Antibodies: Novus Biologicals
Browse our Cholecystokinin Antibodies all backed by our Guarantee+. ... anti-Cholecystokinin antibody, anti-CCK antibody, anti-MGC117187 antibody. 3 Results for "cholecystokinin" in Primary ... Cholecystokinin Antibodies. We offer Cholecystokinin Antibodies for use in common research applications: ELISA, ... Choose from our Cholecystokinin polyclonal antibodies and browse our Cholecystokinin monoclonal antibody catalog. ...
https://www.novusbio.com/primary-antibodies/cholecystokinin
cholecystokinin - definition and meaningcholecystokinin - definition and meaning
cholecystokinin: A hormone produced principally by the small intestine in response to the presence of fats, causing contraction ... It may also increase the level of hormones in the gut (such as cholecystokinin), which is another way to control your appetite ... It may also increase the level of hormones in the gut (such as cholecystokinin), which is another way to control your appetite ... 5 (HealthDay News) -- A gut hormone called cholecystokinin (CCK) plays an important role in the control of blood sugar ...
https://www.wordnik.com/words/cholecystokinin
PHENYLALANINE-STIMULATED SECRETION OF CHOLECYSTOKININ IS CALCIUM-DEPENDENT | RTIPHENYLALANINE-STIMULATED SECRETION OF CHOLECYSTOKININ IS CALCIUM-DEPENDENT | RTI
... an intestinal cholecystokinin (CCK)secreting cell line. Exposure to the amino acid L-phenylalanine increased release of CCK by ... The secretion of cholecystokinin was examined in STC-1 cells, ... The secretion of cholecystokinin was examined in STC-1 cells, ... These results indicate that, in STC-1 cells, L-phenylalanine stimulates release of cholecystokinin via a calcium-dependent ... 1995). PHENYLALANINE-STIMULATED SECRETION OF CHOLECYSTOKININ IS CALCIUM-DEPENDENT. American Journal of Physiology. ...
https://www.rti.org/publication/phenylalanine-stimulated-secretion-cholecystokinin-calcium-dependent
Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal MacrophagesCholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages
... ... "Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages," ...
https://www.hindawi.com/journals/mi/2014/896029/cta/
Cckar - Cholecystokinin receptor type A - Mus musculus (Mouse) - Cckar gene & proteinCckar - Cholecystokinin receptor type A - Mus musculus (Mouse) - Cckar gene & protein
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder ... Cholecystokinin receptor type AAdd BLAST. 436. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder ... sp,O08786,CCKAR_MOUSE Cholecystokinin receptor type A OS=Mus musculus OX=10090 GN=Cckar PE=1 SV=1 ...
https://www.uniprot.org/uniprot/O08786
Human CCKB Cholecystokinin Receptor Cell Line | Charles River Laboratories.Human CCKB Cholecystokinin Receptor Cell Line | Charles River Laboratories.
... including the Human CCKB Cholecystokinin Receptor Cell Line, to meet your drug discovery needs. ... Human CCKB Cholecystokinin Receptor Cell Line. Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the ...
https://www.criver.com/cell-lines/human-cckb-cholecystokinin-receptor-cell-line
Produktübersicht anti-Cholecystokinin AntikörperProduktübersicht anti-Cholecystokinin Antikörper
Ausgesuchte Qualitäts-Hersteller für Cholecystokinin Antikörper. Hier bestellen. ... Monoklonale und polyklonale Cholecystokinin Antikörper für viele Methoden. ... cholecystokinin , cholecystokinin-L , Cholecystokinins , cholecystokinin-N , cholecystokinin triacontatriapeptide , prepro- ... Cholecystokinin type 2 , cholecystokinin (clone CCK-CH), preprocholecystokinin , cholecystokinin B , cholecystokinin type 2 ...
http://www.antikoerper-online.de/t-zell-rezeptor-signalweg-pathway-12/cholecystokinin-antibody-8723/
Evidence for Cholecystokinin Receptor and Intracellular Signal Transduction in Relation to Amylase Secretion | SpringerLinkEvidence for Cholecystokinin Receptor and Intracellular Signal Transduction in Relation to Amylase Secretion | SpringerLink
Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). ... Pig Brain contains cholecystokinin octapeptide and several cholecystokinin desoctapeptides, Proc. Natl. Acad. Sci. USA, 80: ... Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). ... J.P. Christphe, E.K. Frandsen, T.P. Conlon, G. Krishna and J.D. Gardner, Action of cholecystokinin, cholinergic agents and A- ...
https://link.springer.com/chapter/10.1007/978-1-4757-5971-6_8
Receptors, Cholecystokinin | Harvard Catalyst Profiles | Harvard CatalystReceptors, Cholecystokinin | Harvard Catalyst Profiles | Harvard Catalyst
Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes ... Cholecystokinin activates PYK2/CAKbeta by a phospholipase C-dependent mechanism and its association with the mitogen-activated ... Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti- ... "Receptors, Cholecystokinin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Receptors,%20Cholecystokinin
Analysis of duodenal drainage fluid after cholecystokinin (CCK) stimulation in healthy volunteersAnalysis of duodenal drainage fluid after cholecystokinin (CCK) stimulation in healthy volunteers
Pancreatic lipase concentrations in duodenal fluid increase nearly threefold after cholecystokinin stimulation in healthy ... Cholecystokinin was infused at a constant rate of 40 ng/kg per hour. Duodenal fluid was collected on ice for 80 minutes in four ... Analysis of duodenal drainage fluid after cholecystokinin (CCK) stimulation in healthy volunteers Pancreas. 2002 Nov;25(4):350- ... Existing secretory tests using cholecystokinin alone are cumbersome, requiring a unique dual tube (gastric and duodenal) ...
https://pubmed.ncbi.nlm.nih.gov/12409828/?dopt=Abstract
Cholecystokinin-8 molecule - Stock Image C003/2352 - Science Photo LibraryCholecystokinin-8 molecule - Stock Image C003/2352 - Science Photo Library
Computer model showing the structure of the terminal fragment of a molecule of the hormone cholecystokinin-8 (CCK-8). Atoms are ... colour-coded (carbon: large grey, hydrogen: small grey, oxygen: red, nitrogen: blue, sulphur: yellow). Cholecystokinin (CCK) is ... cholecystokinin, cholecystokinin-8, compound, control, cut out, cut outs, cut-out, cut-outs, cutout, cutouts, digestion, ... Caption: Cholecystokinin-8 molecule. Computer model showing the structure of the terminal fragment of a molecule of the hormone ...
http://www.sciencephoto.com/media/96580/view
Cholecystokinin - Pancreozymin Summary Report | CureHunterCholecystokinin - Pancreozymin Summary Report | CureHunter
Cholecystokinin: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central ... Cholecystokinin (Pancreozymin). Subscribe to New Research on Cholecystokinin A peptide, of about 33 amino acids, secreted by ... cholecystokinin 5 out of 16; 3-yr-old, control 10 out of 11, cholecystokinin 3 out of 8. Gallstone formation was significantly ... which suggests the role of cholecystokinin in the feedback control of pancreatic secretion.". 05/01/2000 - "The cholecystokinin ...
http://www.curehunter.com/public/keywordSummaryD002766.do
Cholecystokinin financial definition of cholecystokininCholecystokinin financial definition of cholecystokinin
What is cholecystokinin? Meaning of cholecystokinin as a finance term. What does cholecystokinin mean in finance? ... Definition of cholecystokinin in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Cholecystokinin financial definition of cholecystokinin https://financial-dictionary.thefreedictionary.com/cholecystokinin. ... Related to cholecystokinin: enterogastrone, secretin CCK. GOST 7.67 Latin three-letter geocode for the Cocos Islands. The code ...
https://financial-dictionary.thefreedictionary.com/cholecystokinin
Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator | Journal of NeuroscienceCholecystokinin-like peptide is a modulator of a crustacean central pattern generator | Journal of Neuroscience
Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator. GG Turrigiano and AI Selverston ... Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator ... The presence, release, and physiological effects of a cholecystokinin(CCK)-like peptide within the stomatogastric ganglion (STG ... Cholecystokinin-like peptide is a modulator of a crustacean central pattern generator ...
http://www.jneurosci.org/content/9/7/2486
OctapeptidePeptidesAbstractAntagonistRole of cholecystokininGastricSatietyPancreozyminCCKBRNeuropeptideCCKARDuodenumSecretinIntestinalCCK2RInhibitsGastrointestinal HormonesGeneStimulationCCK1Antagonists in GastroenterologyPancreatic acinar cellsHigh affinityRatsPorcineBasis of cholecystokininRelease of cholecystokininConcentrations of cholecystokininPhysiologicalExocrinePeptide hormonesRadioimmunoassayMolecularProteinsPlasma cholecystokininHormone cholecystokininStimulates cholecystokininDetermines cholecystokininHormonesGallbladder ContractionAgonistsELISA KitFamily of peptideMurineAntibodyGastrin receptorAmide
Octapeptide11
  • Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. (pnas.org)
  • Tryptic digestion converted the intact cholecystokinin from all species to a peptide resembling the COOH-terminal octapeptide. (pnas.org)
  • G.J. Dockray, Immunoreactive component resembling cholecystokinin octapeptide in intestine, Nature, 270: 359 (1977). (springer.com)
  • J. Eng, Y.Shiina, Y.C. E. Pan, R. Blacher, M. Stein and R.S. Yalow, Pig Brain contains cholecystokinin octapeptide and several cholecystokinin desoctapeptides, Proc. (springer.com)
  • Thyrotropin releasing hormone (TRH) and cholecystokinin octapeptide (CCK) are endogenous neuropeptides known to inhibit intake of alcohol. (thefreedictionary.com)
  • The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. (biomedsearch.com)
  • The interaction of the C-terminal octapeptide of cholecystokinin, CCK-8, with the third extracellular loop of human cholecystokinin-A receptor, CCK(A)-R(329-357), has been probed by high-resolution NMR and extensive computer simulations. (rcsb.org)
  • In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. (jneurosci.org)
  • To elucidate the anti-inflammatory mechanism of an intestinal neuropeptide, sulfated cholecystokinin octapeptide (sCCK-8), the effects of sCCK-8 on lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) mRNA expression and NF-κB activity in pulmonary interstitial macrophages (PIMs) were studied. (wjgnet.com)
  • The purposes of this study were to evaluate the cholecystokinin octapeptide amide (CCK8) peptide tagged with a diethylenetriaminepentaacetic acid derivative (DTPAGlu) and to test whether a 111 In-labeled conjugate ( 111 In-DTPAGlu-G-CCK8, a derivative containing the chelating agent DTPAGlu bound through a glycine linker at the N-terminal end of the bioactive peptide CCK8) is suitable for cholecystokinin-B receptor (CCKBR) imaging. (snmjournals.org)
  • Cholecystokinin octapeptide (CCK) injected into the medial hypothalamus of the rat has been reported to suppress feeding. (umassmed.edu)
Peptides10
  • The amphibian caerulein skin peptide, the cockroach leukosulphakinin I and II (LSK) peptides, Drosophila melanogaster (Fruit fly) putative CCK-homologues Drosulphakinins I and II, cionin, a Gallus gallus (Chicken) gastrin/cholecystokinin-like peptide and cionin, a neuropeptide from the protochordate Ciona intestinalis belong to the same family. (ebi.ac.uk)
  • Data suggest that endocrine responses differ between jejunal and gastric enteral feeding, with higher peak plasma CCK (cholecystokinin ), PYY (peptide YY ), and GLP-1/2 ( glucagon -like peptides 1/2) concentrations being attained after jejunal feeding. (antikoerper-online.de)
  • Y. Takeda, Y. Takano and H. Kamiya, Effects of cholecystokinin tetra and octa peptides on locomotor activity in mice, Japan. (springer.com)
  • A. Saito, I.D. Goldfine and J.A. Williams, Characterization of receptors for cholecystokinin and related peptides in mouse cerebral cortex, J. Neurochem. (springer.com)
  • The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. (jneurosci.org)
  • To determine whether the regulatory peptides cholecystokinin (CCK) and the CCK-related peptide gastrin are co-expressed by the corneal epithelium. (arvojournals.org)
  • cholecystokinin and gastrin peptides. (thefreedictionary.com)
  • CCKBR is a G protein-coupled receptor for gastrin and cholecystokinin (CCK), which are regulatory peptides of the brain and gastrointestinal tract. (cellsciences.com)
  • Because the human exorbital lacrimal gland contains immuoreactive cholecystokinin (CCK-8) (Abstract # 4165 ARVO 2010), might the rat Harderian gland, a major lacrimal organ in non-primate terrestrial vertebrates, contain enteric peptides, specifically CCK? (arvojournals.org)
  • Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function. (semanticscholar.org)
Abstract1
  • Abstract: Background: Cholecystokinin (CCK) is an anorexigenic hormone. (fu-berlin.de)
Antagonist12
  • Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. (springer.com)
  • Levels of the opioid-antagonist cholecystokinin in the brain. (encognitive.com)
  • By means of loxiglumide, a potent and highly specific antagonist for cholecystokinin (CCK), the effects of blocking CCK receptors on gastrointestinal motility were investigated in a placebo-controlled study in healthy young men (aged 21-39, mean 24 years). (semanticscholar.org)
  • The gastrin/cholecystokinin-B receptor antagonist L-365,260 reduces basal acid secretion and prevents gastrointestinal damage induced by aspirin, ethanol and cysteamine in the rat. (aspetjournals.org)
  • The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. (biomedsearch.com)
  • BACKGROUND AND PURPOSE: JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK(2) receptors with good pharmacokinetic properties and represents a novel mechanism for the treatment of gastro-oesophageal reflux disease (GORD). (biomedsearch.com)
  • Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion. (bmj.com)
  • Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors. (aspetjournals.org)
  • 3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic membranes. (aspetjournals.org)
  • Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. (semanticscholar.org)
  • A synthetic peptide derivative that is a cholecystokinin receptor antagonist. (semanticscholar.org)
  • Publications] Funakoshi A: 'Effect of a CCK antagonist (CR-1505) on gene expressions of cholecystokinin and secretin in rat intestine. (nii.ac.jp)
Role of cholecystokinin3
  • Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. (harvard.edu)
  • Role of cholecystokinin in the motivational control of instrumental action in rats. (thefreedictionary.com)
  • Role of cholecystokinin as an anti-opio. (encognitive.com)
Gastric4
  • Other than increased blood glucose, arginine and lysine amino acids and gastrointestinal hormones such as gastrin, secretin, cholecystokinin , gastric inhibitory peptide, and growth hormone, cortisol and glucagon have an important role in insulin secretion. (thefreedictionary.com)
  • These undifferentiated cells and also presumably immature epithelial cells in the progenitor zone of adult gastric glands were shown to express cholecystokinin-2 (CCK 2 ) receptors and are therefore targets for the trophic action of gastrin. (diva-portal.org)
  • Background & Aims: Three pathways control gastric acid secretion: the gastrin-enterochromaffin-like (ECL) cell axis, the vagus-parietal cell axis, and the cholecystokinin (CCK)-D cell axis. (lu.se)
  • Cholecystokinin plays a major role in maintaining nutritional homeostasis through its involvement in processes such as gastric emptying, gallbladder contraction, and pancreatic exocrine secretion. (multispaninc.com)
Satiety10
  • One hypothesis is that meal-induced secretion of cholecystokinin activates the satiety centre of the hypothalamus in the brain so that the person feels full and stops eating. (britannica.com)
  • A second hypothesis is that, because cholecystokinin inhibits emptying of the stomach, the sensation of satiety may be the result of distension of the stomach. (britannica.com)
  • Cholecystokinin may be the mediator of satiety. (nih.gov)
  • In a study published in the Journal of Nutrition, researchers observed that a single test meal with high-fiber beans produced a two-fold greater increase in the satiety hormone cholecystokinin (CCK), compared to a control test meal without beans. (thefreedictionary.com)
  • Ileal interposition attenuates the satiety responses evoked by cholecystokinin-8 and -33. (sigmaaldrich.com)
  • However, since this surgery involves both lower and upper gut segments, we tested the hypothesis that II alters the satiety responses evoked by the classic upper gut peptide cholecystokinin (CCK). (sigmaaldrich.com)
  • Using this assay we have demonstrated that cholecystokinin is important in control of satiety in humans. (clinsci.org)
  • The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. (jci.org)
  • Publications] Miyasaka K: 'Gene expression of cholecystokinin (CCK) and CCK receptors, and its satiety effect in young and old male rats. (nii.ac.jp)
  • Beta-cell glucose sensitivity, insulin clearance, cholecystokinin values, and subjective satiety ratings were unaffected. (mdpi.com)
Pancreozymin5
  • Cholecystokinin (CCK) , formerly called pancreozymin , a digestive hormone released with secretin when food from the stomach reaches the first part of the small intestine ( duodenum ). (britannica.com)
  • Cholecystokinin, otherwise known as CCK or CCK-PZ, is a hormone that was once called pancreozymin because of its actions on the pancreas. (hormone.org)
  • C. Yanaihara, N. Sugiura, K. Kashimoto, M. Kondo, M. Kawamura, S. Naruse, A. Yasui and N. Yanaihara, Dissociation of pancreozymin (PZ) activity from cholecystokinin (CCK) activity by Na-carboxyacyl CCK-7 and CCK-8 analogues with a substituted glycine. (springer.com)
  • Cholecystokinin, officially called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. (wikipedia.org)
  • Cholecystokinin, previously called pancreozymin , is synthesised by I-cells and secreted in the duodenum, the first segment of the small intestine, and causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively. (chemeurope.com)
CCKBR2
  • The cholecystokinin B receptor also known as CCKBR or CCK 2 is a protein [5] that in humans is encoded by the CCKBR gene . (wikipedia.org)
  • In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. (bibsys.no)
Neuropeptide3
  • Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. (criver.com)
  • Ghrelin, neuropeptide Y (NPY) and cholecystokinin (CCK) in blunt snout bream (Megalobrama amblycephala): cDNA cloning, tissue distribution and mRNA expression changes responding to fasting and refeeding. (thefreedictionary.com)
  • The cholecystokinin (CCK) receptors CCK1R and CCK2R exert important central and peripheral functions by binding the neuropeptide cholecystokinin. (aspetjournals.org)
CCKAR9
  • cholecystokinin type A receptor (CCKAR) (Rikimaru et al. (thefreedictionary.com)
  • We found that mRNA of cholecystokinin type-A receptor (CCKAR) is gradually expressed during postnatal development in rat pancteas, though it is not observed in fetal pancreas. (nii.ac.jp)
  • This assay has high sensitivity and excellent specificity for detection of Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • No significant cross-reactivity or interference between Cholecystokinin A Receptor (CCKAR) and analogues was observed. (uscnk.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Cholecystokinin A Receptor (CCKAR) were tested 20 times on one plate, respectively. (uscnk.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Cholecystokinin A Receptor (CCKAR) were tested on 3 different plates, 8 replicates in each plate. (uscnk.com)
  • The microplate provided in this kit has been pre-coated with an antibody specific to Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Cholecystokinin A Receptor (CCKAR). (uscnk.com)
  • Upon plate development, the intensity of the emitted light is proportional to the Cholecystokinin A Receptor (CCKAR) level in the sample or standard. (uscnk.com)
Duodenum7
  • and the contraction of the gallbladder , which forces bile into duodenum, an action ascribed to cholecystokinin. (britannica.com)
  • Cholecystokinin is a hormone produced in the I-cells that line the duodenum. (hormone.org)
  • Most pancreatic exocrine stimulation comes from the duodenum, which releases cholecystokinin and secretin, targeting acinar and ductal cells, respectively. (thefreedictionary.com)
  • Upon secretion of cholecystokinin when chyme enters the small intestine, the gall bladder releases bile through the cystic duct (joins into the common hepatic and common bile ducts) into the duodenum (Huether, 2008a). (thefreedictionary.com)
  • After IV administration of cholecystokinin, the resultant pancreatic secretion of amylase, trypsin, and lipase is measured by collection through a tube in the duodenum. (thefreedictionary.com)
  • Gastrin-releasing peptide stimulates cholecystokinin secretion in perfused rat duodenum. (mysciencework.com)
  • We examined the effect of porcine gastrin-releasing peptide (GRP-27) and other analogous neuropeptides on cholecystokinin (CCK) secretion from the isolated perfused rat duodenum. (mysciencework.com)
Secretin3
  • This test is often combined with the secretin test and is called the secretin-cholecystokinin test. (thefreedictionary.com)
  • Publications] Miyasaka K: 'Involvement of gene expressions of cholecystokinin and secretin in lumianl feedback regulation in conscious rats. (nii.ac.jp)
  • Publications] Funakoshi A: 'Changes in gene expressions of pancreatitis associated protein and pancreatic secretory trypsin inhibitors in experimental pancreatjtis produced by pancreatic duct occlustion in rats : Comparison with gene expressions of cholecystokinin and secretin. (nii.ac.jp)
Intestinal4
  • The secretion of cholecystokinin was examined in STC-1 cells, an intestinal cholecystokinin (CCK)secreting cell line. (rti.org)
  • Cardiac expression of pro- cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons. (antikoerper-online.de)
  • Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. (harvard.edu)
  • Ghrelin is an important gut-derived hormone with an appetite stimulatory role, while most of the intestinal hormones, including cholecystokinin (CCK), peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), are appetite-inhibitors. (ucm.es)
CCK2R2
  • The cholecystokinin (CCK) 2 receptor (CCK2R) appears as a pharmacological target for the treatment of many major diseases. (inserm.fr)
  • Minigastrin (MG) analogs show high affinity to the cholecystokinin-2 receptor (CCK2R) and have therefore been intensively studied to find a suitable analog for imaging and treatment of CCK2R-expressing tumors. (thno.org)
Inhibits1
  • Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. (ucl.ac.uk)
Gastrointestinal Hormones1
  • These possess receptors for and functional actions of gastrointestinal hormones such as amylin, cholecystokinin , ghrelin, and peptide YY in the area postrema and subfornical organ. (thefreedictionary.com)
Gene10
  • In addition, variations with the cholecystokinin gene have been connected to obesity, but the reason for this is not yet known. (hormone.org)
  • The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. (lu.se)
  • We also found two base changes in promoter region of human cholecystokinin type-A receptor gene, a G to T change in -128 nucleotide and an Ato G change in -81 nucleotide. (nii.ac.jp)
  • Publications] Kimihiko Matsusue, Soichi Takiguchi, Yutaka Takata, Akihiko Funakoshi, Kyoko Miyasaka, Akira Kono: 'Expression of Cholecystokinin Type A Receptor Gene Correates with DNA Demethylation during Postnatal Development of Rat Pancreas'Biochem.Biophys.Res.Commun. (nii.ac.jp)
  • Publications] Akihiro Funakoshi, Kyoko Miyasaka, Hideo Matsumoto, Shunji Yamamori, Soichi Takiguchi, Kazuhiro Kataoka, Yutaka Takata, Kimihiko Matsusue, Akira Kono, Hiroshi Shimokata: 'Gene structure of human cholecystokinin(CCK) type-A receptor : body fat content is related CCK type-A receptor gene promoter polymorphism'FEBS Letters. (nii.ac.jp)
  • Publications] Kimihiko Matsusue, Soichi Takiguchi, Yutaka Takata, Akihiko Funakoshi, Kyoko Miyasaka, Akira Kono: 'Expression of Cholecystokinin Type A Receptor Gene Correates with DNA Demethylation during Postnatal Development of Rat Pancreas'Biochem. (nii.ac.jp)
  • Publications] Akihiro Funakoshi, Kyoko Miyasaka, Hideo Matsumoto, Shunji Yamamori, Kazuhiro Kataoka, Yutaka Takata, Kimihiko Matsusue, Akira Kono, Hiroshi Shimokata: 'Gene structure of human cholecystokinin(CCK)type-A receptor : body fat content is related CCK type-A receptor gene promoter polymorphism'FEBS Letters. (nii.ac.jp)
  • Publications] Miyasakak K: 'Sex difference in gene expressions of cholecystokinin (CCK) and CCK receptor in young and old rats. (nii.ac.jp)
  • Publications] Miyasaka K: 'Changes in gene expression of cholecystokinin-A receptor after induction of pancreatitis by pancreatic duct occlusion in rats. (nii.ac.jp)
  • Publications] Funakoshi A: 'An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. (nii.ac.jp)
Stimulation7
  • A simpler, quantitative cholecystokinin stimulation test that measures enzyme concentrations (in international units per liter [IU/L]) instead of total output would obviate need for marker perfusion/collection. (nih.gov)
  • The aim of our experiment was to study the secretory patterns of pancreatic enzyme concentration in duodenal fluid after cholecystokinin stimulation in healthy volunteers. (nih.gov)
  • Pancreatic lipase concentrations in duodenal fluid increase nearly threefold after cholecystokinin stimulation in healthy volunteers. (nih.gov)
  • Stimulation of cholecystokinin secretion was seen after exposure to agents anticipated to increase the level of intracellular calcium, including thapsigargin (8 muM), bombesin (50 nM), potassium-induced depolarization (50 mM), or after blockade of potassium channels with barium chloride (2 mM). (rti.org)
  • Potato Extract (Potein) Suppresses Food Intake in Rats through Inhibition of Luminal Trypsin Activity and Direct Stimulation of Cholecystokinin Secretion from Enteroendocrine Cells. (thefreedictionary.com)
  • The cholecystokinin (CCK) receptor on the rat pancreatic acinar cell is a guanine nucleotide-binding protein (G protein)-coupled receptor, which was recently demonstrated to be phosphorylated in response to agonist stimulation (Klueppelberg et al. (elsevier.com)
  • Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S. Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats. (chemeurope.com)
CCK12
  • Frozen Cells validated for calcium testing: Cholecystokinin CCK1 receptor, human recombinant, in 1321N1 host cell. (perkinelmer.com)
  • Background and Aims: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). (elsevier.com)
Antagonists in Gastroenterology1
  • Cholecystokinin Antagonists in Gastroenterology by Guido Adler & Christoph Beglinger, 9783642763625. (collinsbooks.com.au)
Pancreatic acinar cells2
  • Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. (springer.com)
  • R.T. Jensen, G.F. Lemp and J.D. Gardner, Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells, Proc. (springer.com)
High affinity2
  • Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. (harvard.edu)
  • Two photolabile cholecystokinin analogues were developed and characterized as representing high-affinity, fully biologically active probes with sites of covalent attachment at positions 28 and 31. (monash.edu)
Rats1
  • What's more, the researchers show that rats fed a high-fat diet for a few days become resistant to the glucose-lowering hormone known as cholecystokinin (CCK). (wordnik.com)
Porcine2
  • The failure to detect intact cholecystokinin in extracts from monkey or dog by using an antiserum developed by immunization with porcine cholecystokinin is presumed to be due to marked species differences in the NH2-terminal portion of the molecule. (pnas.org)
  • Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). (springer.com)
Basis of cholecystokinin1
  • Miller LJ, Gao F. Structural basis of cholecystokinin receptor binding and regulation. (springer.com)
Release of cholecystokinin3
  • These results indicate that, in STC-1 cells, L-phenylalanine stimulates release of cholecystokinin via a calcium-dependent process. (rti.org)
  • Slendesta[R] is an all-natural ingredient that promotes the body's release of cholecystokinin , a peptide that makes a person feel fuller. (thefreedictionary.com)
  • STC-1 cells may serve as a model system to study the electrophysiological and secretory mechanisms involved in the release of cholecystokinin. (rti.org)
Concentrations of cholecystokinin2
  • Plasma concentrations of cholecystokinin were measured using a novel sensitive and specific radioimmunoassay. (clinsci.org)
  • 4. This paper describes a novel radioimmunoassay for measurement of plasma concentrations of cholecystokinin. (clinsci.org)
Physiological2
  • The presence, release, and physiological effects of a cholecystokinin(CCK)-like peptide within the stomatogastric ganglion (STG) of the lobster, Panulirus interruptus, are described. (jneurosci.org)
  • 2. In this study cholecystokinin-8 was infused intravenously to six healthy subjects in doses that reproduced physiological post-prandial concentrations. (clinsci.org)
Exocrine3
  • This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of newborn calves. (antikoerper-online.de)
  • This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of neonatal pigs. (antikoerper-online.de)
  • Long-term comparative effect of cholecystokinin and gastrin on mouse stomach, antrum, intestine and exocrine pancreas. (thefreedictionary.com)
Peptide hormones3
  • Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin . (rug.nl)
  • Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviors. (ebi.ac.uk)
  • It is a member of the gastrin/cholecystokinin family of peptide hormones and is very similar in structure to gastrin, another gastrointestinal hormone. (wikipedia.org)
Radioimmunoassay2
  • Secretory and electrophysiological properties of STC-1 cells, a cholecystokinin-secreting cell line, were examined with a radioimmunoassay and patch-clamp recording techniques. (rti.org)
  • A sensitive radioimmunoassay for cholecystokinin (CCK) has been developed. (garvan.org.au)
Molecular2
  • Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. (springer.com)
  • This work focuses on the use of photoaffinity labeling and molecular modeling to elucidate the structural basis of binding a natural peptide ligand to a family A G protein-coupled receptor, the type 1 cholecystokinin receptor. (monash.edu)
Proteins2
  • Cholecystokinin (CCK) is a family of hormones responsible for promoting the digestion of fats and proteins. (sciencephoto.com)
  • Cholecystokinin (CCK) is a peptide hormone responsible for stimulating the digestion of fat and proteins. (thefreedictionary.com)
Plasma cholecystokinin1
  • With saline infusion there was no premeal increase in plasma cholecystokinin concentration. (clinsci.org)
Hormone cholecystokinin4
  • The hormone cholecystokinin (CCK) was discovered in 1928 by Ivy and Oldberg, based on its ability to stimulate gallbladder contraction. (springer.com)
  • Computer model showing the structure of the terminal fragment of a molecule of the hormone cholecystokinin-8 (CCK-8). (sciencephoto.com)
  • 1. Intravenous infusions of the brain/gut hormone, cholecystokinin, have been shown to reduce food intake in a subsequent test meal. (clinsci.org)
  • In the presence of adipocytes, prostate cancer cells actively secrete the peptide hormone cholecystokinin (CCK), which not only stimulates prostate CSC self-renewal, but also induces cathepsin B (CTSB) production of the adipocytes. (oncotarget.com)
Stimulates cholecystokinin1
Determines cholecystokinin1
  • In addition to the above the report determines cholecystokinin fragment 30-33 amide hydrochloride consumers. (marketpublishers.com)
Hormones3
  • While research is still underway to determine what impact cholecystokinin has on obesity and health, your doctor can help you determine if your hormones may be impacting your health. (hormone.org)
  • It may also increase the level of hormones in the gut (such as cholecystokinin ), which is another way to control your appetite. (wordnik.com)
  • Pine nut oil contains pinolenic acid, a fatty acid that stimulates the body to produce two natural appetite suppressants: the hormones cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1). (wordnik.com)
Gallbladder Contraction2
  • Cholecystokinin receptor A (CCK-AR) mediates signals resulting in gallbladder contraction. (ovid.com)
  • Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder contraction factor. (regionh.dk)
Agonists2
  • Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor. (semanticscholar.org)
  • Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists. (semanticscholar.org)
ELISA Kit1
  • Your search returned 687 cholecystokinin ELISA ELISA Kit across 21 suppliers. (biocompare.com)
Family of peptide1
  • Cholecystokinin belongs to the gastrin family of peptide groups. (frontiersin.org)
Murine1
  • Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine. (semanticscholar.org)
Antibody3
  • Each Cholecystokinin Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Cholecystokinin polyclonal antibodies and browse our Cholecystokinin monoclonal antibody catalog. (novusbio.com)
  • Immunohistochemical staining was by a rabbit polyclonal antibody marketed as Anti-Cholecystokinin (26-33) (sulfated CCK-8) by Sigma-Aldrich. (arvojournals.org)
Gastrin receptor1
Amide6
  • CHOLECYSTOKININ FRAGMENT 30-33 AMIDE HYDROCHLORIDE (CAS 5609-49-4) Market Research Report 2018 aims at providing comprehensive data on cholecystokinin fragment 30-33 amide hydrochloride market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • The report includes cholecystokinin fragment 30-33 amide hydrochloride description, covers its application areas, manufacturing methods, patents. (marketpublishers.com)
  • It captures cholecystokinin fragment 30-33 amide hydrochloride market trends, pays close attention to cholecystokinin fragment 30-33 amide hydrochloride manufacturers and names suppliers. (marketpublishers.com)
  • Besides, the report provides cholecystokinin fragment 30-33 amide hydrochloride prices in regional markets. (marketpublishers.com)
  • CHOLECYSTOKININ FRAGMENT 30-33 AMIDE HYDROCHLORIDE (CAS 5609-49-4) Market Research Report 2018 contents were worked out and placed on the website in February, 2018. (marketpublishers.com)
  • Please note that CHOLECYSTOKININ FRAGMENT 30-33 AMIDE HYDROCHLORIDE (CAS 5609-49-4) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
Cholecystokinin-1 Receptor | SpringerLink
Cholecystokinin-1 Receptor | SpringerLink (link.springer.com)
Cholecystokinin (Injection Route) Description and Brand Names - Mayo Clinic
Cholecystokinin (Injection Route) Description and Brand Names - Mayo Clinic (mayoclinic.org)
How Does Your Stomach Tell Your Brain That You're Full? | Livestrong.com
How Does Your Stomach Tell Your Brain That You're Full? | Livestrong.com (livestrong.com)
Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes | Nature Methods
Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes | Nature Methods (nature.com)
CCKBR Gene - GeneCards | GASR Protein | GASR Antibody
CCKBR Gene - GeneCards | GASR Protein | GASR Antibody (genecards.org)
Bradykinin - Wikipedia
Bradykinin - Wikipedia (en.wikipedia.org)
Insulin-like growth factor 2 - Wikipedia
Insulin-like growth factor 2 - Wikipedia (en.wikipedia.org)
Neuromedin N - Wikipedia
Neuromedin N - Wikipedia (en.wikipedia.org)
Pancreatic polypeptide - Wikipedia
Pancreatic polypeptide - Wikipedia (en.wikipedia.org)
Stomach - Wikipedia
Stomach - Wikipedia (en.wikipedia.org)
Orexin - Wikipedia
Orexin - Wikipedia (en.wikipedia.org)
Neurotensin receptor 1 - Wikipedia
Neurotensin receptor 1 - Wikipedia (en.wikipedia.org)
Ethylenediaminetetraacetic acid - Wikipedia
Ethylenediaminetetraacetic acid - Wikipedia (en.wikipedia.org)
Radiopeptide Imaging and Therapy in Europe | Journal of Nuclear Medicine
Radiopeptide Imaging and Therapy in Europe | Journal of Nuclear Medicine (jnm.snmjournals.org)
Species specificity of cholecystokinin in gut and brain of several mammalian species | PNAS
Species specificity of cholecystokinin in gut and brain of several mammalian species | PNAS (pnas.org)
25679-24-7 - Cholecystokinin (26-33), non-sulfated - Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH|sub|2|/sub| - CCK Octapeptide (26-33),...
25679-24-7 - Cholecystokinin (26-33), non-sulfated - Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH|sub|2|/sub| - CCK Octapeptide (26-33),... (alfa.com)
Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives | SpringerLink
Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives | SpringerLink (link.springer.com)
Duodenum | anatomy | Britannica.com
Duodenum | anatomy | Britannica.com (britannica.com)
Endocannabinoids and Energy Homeostasis | SpringerLink
Endocannabinoids and Energy Homeostasis | SpringerLink (link.springer.com)
Cholecystokinin Antagonists in Gastroenterology | Springer for Research & Development
Cholecystokinin Antagonists in Gastroenterology | Springer for Research & Development (rd.springer.com)
What are the long-term advantages of preventing the development of obesity in childhood and adolescence?
What are the long-term advantages of preventing the development of obesity in childhood and adolescence? (medscape.com)
What is the relationship between obesity in adolescence and obesity in adulthood?
What is the relationship between obesity in adolescence and obesity in adulthood? (medscape.com)
Peptide Humors | SpringerLink
Peptide Humors | SpringerLink (link.springer.com)
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells | PNAS
Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells | PNAS (pnas.org)
What are the race-related demographics of obesity in children, and which ethic groups have the highest incidence of childhood...
What are the race-related demographics of obesity in children, and which ethic groups have the highest incidence of childhood... (medscape.com)
Which genetic syndromes are associated with childhood obesity?
Which genetic syndromes are associated with childhood obesity? (medscape.com)
What is the role of insufficient cardiorespiratory fitness in weight gain and the risk of being overweight in children aged 6...
What is the role of insufficient cardiorespiratory fitness in weight gain and the risk of being overweight in children aged 6... (medscape.com)
Antagonistic negative and positive neurons of the basolateral amygdala | Nature Neuroscience
Antagonistic negative and positive neurons of the basolateral amygdala | Nature Neuroscience (nature.com)
Product Search for reporter cell lines: Novus Biologicals
Product Search for reporter cell lines: Novus Biologicals (novusbio.com)
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance | SpringerLink
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance | SpringerLink (link.springer.com)