Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Calcifediol: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.NebraskaDihydrotachysterol: A VITAMIN D that can be regarded as a reduction product of vitamin D2.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.24,25-Dihydroxyvitamin D 3: A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhances the calcemic effect of CALCITRIOL.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.25-Hydroxyvitamin D 2: 9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Calcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Steroid Hydroxylases: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Cholestanetriol 26-Monooxygenase: An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol intermediates such as the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol.Trichosurus: A genus of brush-tailed possums found chiefly in Australia and New Zealand. Secretions from their ANAL GLAND function both in defense and demarcating territory.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Calcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.25-Hydroxyvitamin D3 1-alpha-Hydroxylase: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Pest Control: The reduction or regulation of the population of noxious, destructive, or dangerous plants, insects, or other animals. This includes control of plants that serve as habitats or food sources for animal pests.Receptors, Calcitriol: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Food, Fortified: Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Diet: Regular course of eating and drinking adopted by a person or animal.Sunlight: Irradiation directly from the sun.Calcium Radioisotopes: Unstable isotopes of calcium that decay or disintegrate emitting radiation. Ca atoms with atomic weights 39, 41, 45, 47, 49, and 50 are radioactive calcium isotopes.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)S100 Calcium Binding Protein G: A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.Bread: Baked food product made of flour or meal that is moistened, kneaded, and sometimes fermented. A major food since prehistoric times, it has been made in various forms using a variety of ingredients and methods.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Nutritional Requirements: The amounts of various substances in food needed by an organism to sustain healthy life.Hypervitaminosis A: A symptom complex resulting from ingesting excessive amounts of VITAMIN A.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. (1/960)

p21(Cip1/WAF1) inhibits cell-cycle progression by binding to G1 cyclin/CDK complexes and proliferating cell nuclear antigen (PCNA) through its N- and C-terminal domains, respectively. The cell-cycle inhibitory activity of p21(Cip1/WAF1) is correlated with its nuclear localization. Here, we report a novel cytoplasmic localization of p21(Cip1/WAF1) in peripheral blood monocytes (PBMs) and in U937 cells undergoing monocytic differentiation by in vitro treatment with vitamin D3 or ectopic expression of p21(Cip1/WAF1), and analyze the biological consequences of this cytoplasmic expression. U937 cells which exhibit nuclear p21(Cip1/WAF1) demonstrated G1 cell-cycle arrest and subsequently differentiated into monocytes. The latter event was associated with a cytoplasmic expression of nuclear p21(Cip1/WAF1), concomitantly with a resistance to various apoptogenic stimuli. Biochemical analysis showed that cytoplasmic p21(Cip1/WAF1) forms a complex with the apoptosis signal-regulating kinase 1 (ASK1) and inhibits stress-activated MAP kinase cascade. Expression of a deletion mutant of p21(Cip1/WAF1) lacking the nuclear localization signal (DeltaNLS-p21) did not induce cell cycle arrest nor monocytic differentiation, but led to an apoptosis-resistant phenotype, mediated by binding to and inhibition of the stress-activated ASK1 activity. Thus, cytoplasmic p21(Cip1/WAF1) itself acted as an inhibitor of apoptosis. Our findings highlight the different functional roles of p21(Cip1/WAF1), which are determined by its intracellular distribution and are dependent on the stage of differentiation.  (+info)

1Alpha,25dihydroxyvitamin D3 and platinum drugs act synergistically to inhibit the growth of prostate cancer cell lines. (2/960)

The majority of men who die from prostate cancer (PC) have hormone-refractory disease. To date, chemotherapeutic agents have had little or no impact on the survival of such patients. To explore a new approach for the treatment of hormone-refractory PC, we examined the combination effects of cis- or carboplatin with vitamin D. 1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) and its synthetic analogue, Ro 25-6760, have an antiproliferative effect on some prostate cancer cell lines. Consequently, the growth-inhibitory effects of the drugs were measured, both singularly and in combination with cis- or carboplatin, on PC cells. Our results show that although each of the drugs alone displayed antiproliferative activity, the growth inhibition of PC cells was further enhanced by the combination of 1alpha,25(OH)2D3 or Ro 25-6760 and either platinum agent. The greatest enhancement of inhibition occurred using smaller concentrations of the platinum compound in combination with higher concentrations of 1alpha,25(OH)2D3. Isobologram analysis revealed that 1alpha,25(OH)2D3 and platinum acted in a synergistic manner to inhibit the growth of PC cells. Our findings suggest that there is potential clinical value in combining 1alpha,25(OH)2D3 with platinum compounds for the treatment of advanced-stage human PC.  (+info)

Plasma 25-hydroxyvitamin D in growing kittens is related to dietary intake of cholecalciferol. (3/960)

Vitamin D synthesis by growing kittens exposed to ultraviolet light is ineffective. Concentration of 25-hydroxyvitamin D (25-OHD) in plasma (the most useful index of vitamin D status) was measured in six groups each of seven kittens given a purified diet (12 g calcium and 8 g phosphorus/kg, calculated metabolizable energy = 20 kJ/g) that contained either 0.0, 3.125, 6.25, 12.5, 18.75 or 25 microg of cholecalciferol/kg diet. All kittens received these diets from 9 to 22 wk of age, and the two groups given the 0.0 and 3.125 microg cholecalciferol/kg treatments continued to receive the diets until they were 34 wk old. Total and ionizable calcium and phosphorus in plasma were not affected by treatments. No adverse clinical changes were observed or found on radiographic examination of the kittens at 22 or 34 wk of age. Plasma concentration of 25-OHD was linearly related (r2 = 0.99, P < 0.001) to dietary intake of cholecalciferol. Plasma concentration of 25-OHD in kittens given the diet without added vitamin D was significantly less at 22 wk than at 9 wk, whereas kittens receiving the diet containing 3.125 microg cholecalciferol/kg had significantly higher 25-OHD concentrations at 22 and 34 wk than at 9 wk of age. Kittens given the 6.25 microg cholecalciferol/kg diet had plasma 25-OHD concentrations at 22 wk > 50 nmol/L which is considered replete for humans. An allowance of 6. 25 microg (250 IU) of cholecalciferol/kg diet is suggested to provide a margin of safety.  (+info)

Structure-function studies of new C-20 epimer pairs of vitamin D3 analogs. (4/960)

A growing number of calcitriol (1alpha,25-dihydroxyvitamin D3) analogs have become available in recent years. Many of these analogs exhibit lower calcemic effects than calcitriol and inhibit cell proliferation and enhance cell differentation more efficiently than calcitriol. We have compared structure-function relationships of a series of new C-20 epimer (20-epi) vitamin D3 analogs with their natural C-20 counterparts. In human MG-63 osteosarcoma cells, quantification of cellular osteocalcin mRNA levels by Northern blot analysis and osteocalcin biosynthesis by radioimmunoassay indicated that most studied analogs at a concentration of 10 nm induced osteocalcin gene expression more efficiently than the parent compound, calcitriol. Interestingly, when the biological responses were compared with the binding affinities of the analogs to in-vitro translated human vitamin D receptor and with their ability to protect the receptor against partial proteolytic digestion, significant correlations were not observed. Further, molecular modelling of the compounds by energy minimization did not reveal marked differences in the three-dimensional structures of the analogs. These results suggest that higher than normal ligand binding affinity or 'natural' conformation of the ligand-receptor complex are not necessarily required for the 'superagonist' transactivation activity. The mechanism of action of the efficient analogs may involve stabilization and/or differential binding of transcriptional coactivators or transcription intermediary factors to the hVDR during transactivation.  (+info)

1alpha,25-dihydroxy-3-epi-vitamin D3: in vivo metabolite of 1alpha,25-dihydroxyvitamin D3 in rats. (5/960)

We recently identified 1alpha,25-dihydroxy-3-epi-vitamin D3 as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes. We now report the isolation of 1alpha,25-dihydroxy-3-epi-vitamin D3 from the serum of rats treated with pharmacological doses of 1alpha,25-dihydroxyvitamin D3. 1alpha,25-dihydroxy-3-epi-vitamin D3 was identified through its co-migration with synthetic 1alpha,25-dihydroxy-3-epi-vitamin D3 on both straight and reverse phase high performance liquid chromatography systems and by mass spectrometry. Along with 1alpha,25-dihydroxy-3-epi-vitamin D3, other previously known metabolites, namely, 1alpha,24(R),25-trihydroxyvitamin D3, 1alpha,25-dihydroxy-24-oxo-vitamin D3 and 1alpha,25-dihydroxyvitamin D3-26,23-lactone, were also identified. Thus, our study for the first time provides direct evidence to indicate that 1alpha,25-dihydroxy-3-epi-vitamin D3 is an in vivo metabolite of 1alpha,25-dihydroxyvitamin D3 in rats.  (+info)

Cloning of porcine 25-hydroxyvitamin D3 1alpha-hydroxylase and its regulation by cAMP in LLC-PK1 cells. (6/960)

The 25-hydroxyvitamin D3 1alpha-hydroxylase, also referred to as CYP27B1, is a mitochondrial cytochrome P450 enzyme that catalyzes the biosynthesis of 1alpha, 25-dihydroxyvitamin D3 (1alpha,25(OH)2D3) from 25-hydroxyvitamin D3 in renal proximal tubular cells. Recently, human, mouse, and rat CYP27B1 cDNA have been cloned, however the gene regulation has not been fully elucidated. In the present study, porcine CYP27B cDNA was cloned, and the effects of cAMP and vitamin D3 on the regulation of CYP27B1 mRNA expression in LLC-PK1 cells were examined. PCR cloning revealed that porcine CYP27B1 cDNA consisted of 2316 bp, encoding a protein of 504 amino acids. The deduced amino acid sequence showed over 80% identity to the human, mouse, and rat enzyme. LLC-PK1 cells were incubated with humoral factors, and expression of CYP27B1 mRNA was measured by a quantitative reverse transcription-PCR. At the completion of 3-, 6-, 12-, and 24-h incubations, 500 micromol/L 8-bromo-cAMP had significantly increased CYP27B1 mRNA expression (260 to 340%). The adenylate cyclase activator forskolin at 50 micromol/L also had a stimulatory effect at 6 h (190%). Moreover, the protein kinase A inhibitor H-89 reduced the cAMP effect. On the other hand, 1alpha,25(OH)2D3 had no effect on CYP27B1 mRNA expression at 10 and 100 nmol/L, whereas expression of 25-hydroxyvitamin D3 24-hydroxylase (CYP24) mRNA was markedly increased by 1alpha,25(OH)2D3. These findings suggest that LLC-PK1 cells express CYP27B1 mRNA, and that cAMP is an upregulating factor of the CYP27B1 gene in vitro.  (+info)

Vitamin D3 supplementation of beef steers increases longissimus tenderness. (7/960)

The objectives of these experiments were to determine 1) the effectiveness of supplemental vitamin D3 (VITD) on altering plasma and muscle calcium levels, 2) whether VITD supplementation improves Warner-Bratzler shear force (WBS) values of steaks from feedlot beef steers, and 3) the tenderness response curve of longissimus steaks from steers supplemented with VITD. In Exp. 1, 20 crossbred steers were assigned randomly to one of four treatment diets consisting of either 0, 2.5, 5.0, or 7.5 x 106 IU of VITD per day for 10 d. Blood samples were obtained daily during this supplementation period and 5 d thereafter (d 11 to 15). Between d 6 and 13, a linear increase (P < .01) in ionized plasma calcium concentrations was observed in steers supplemented with VITD. Compared to unsupplemented steers, serum calcium concentrations of the steers receiving 7.5 x 106 IU of VITD per day were increased 8 to 48%. In Exp. 2, longissimus samples from crossbred steers (n = 118) that were supplemented with either 0 or 5 x 106 IU of VITD per day for 7 d were obtained and aged for 7, 14, or 21 d. Following the initial 7-d postmortem aging period, VITD supplementation lowered (P < .01) WBS (.58 kg) and increased sensory tenderness rating (.6 units) compared to cuts originating from unsupplemented steers. In Exp. 3, 44 steers were supplemented with either 0 or 7.5 x 106 IU of VITD per day for 10 d immediately prior to slaughter. Results indicated that plasma and longissimus calcium concentration were higher (P < .05) for steers that received supplemental VITD. Compared with unsupplemented cuts, VITD supplementation improved WBS of cuts aged for either 7 or 14 d (P = .02 and P = .07, respectively). Sensory panelists rated samples from VITD supplemented steers as more tender than their unsupplemented counterparts. Activation of calpain proteases could be responsible for the observed tenderization due to the supplementation of VITD.  (+info)

A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun. (8/960)

We previously described a control element in the granulocyte-macrophage colony-stimulating factor (GM-CSF) enhancer that is necessary and sufficient to mediate both transcriptional activation in response to T-cell stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] through the vitamin D3 receptor (VDR). This DNA element is a composite site that is recognized by both Fos-Jun and NFAT1; it is directly bound by VDR in the absence of a retinoid X receptor as an apparent monomer, and it is bound in a unique tertiary conformation. We describe here the mechanism by which VDR elicits its transcriptional inhibitory effect. Firstly, VDR outcompetes NFAT1 for binding to the composite site. Overexpression of NFAT1 in vivo by transient transfection is able to relieve the 1,25(OH)2D3-dependent repression. Secondly, VDR stabilizes the binding of a Jun-Fos heterodimer to the adjacent AP-1 portion of the element. This appears to occur through a direct interaction between VDR and c-Jun, as demonstrated in vitro by direct glutathione S-transferase coprecipitation assays. In vivo, overexpression of c-Jun, but not c-Fos, leads to a rescue of the 1, 25(OH)2D3-mediated repression. Transfected FLAG-VDR bound to the NFAT1-AP-1 DNA binding element can be selectively precipitated from nuclear extracts that are made from cells treated with activating agents in the presence of 1,25(OH)2D3. VDR is not detected in the complex in the absence of the ligand. Thus, VDR acts selectively on the two components required for activation of this promoter/enhancer: it competes with NFAT1 for binding to the composite site, positioning itself adjacent to Jun-Fos on the DNA. Co-occupancy apparently leads to an inhibitory effect on c-Jun's transactivation function. These two events mediated by VDR effectively block the NFAT1-AP-1 activation complex, resulting in an attenuation of activated GM-CSF transcription.  (+info)

TY - JOUR. T1 - Dietary cholecalciferol and calcium levels in a western-style defined rodent diet alter energy metabolism and inflammatory responses in mice. AU - Bastie, Claire C.. AU - Gaffney-Stomberg, Erin. AU - Lee, Ting Wen A. AU - Dhima, Elena. AU - Pessin, Jeffrey E.. AU - Augenlicht, Leonard H.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Male and female C57Bl6 mice were fed a control AIN76A diet, a new Western-style diet (NWD1) reflecting dietary patterns linked to elevated colon cancer incidence (higher fat, lower cholecalciferol, calcium, methyl donors, fiber), or NWD1 with elevated cholecalciferol and calcium (NWD2) from weaning. After 24 wk, serum 25-hydroxyvitamin D [25(OH)D] decreased by ,80% in the NWD1 group compared with controls, but with no alteration in serum calcium or bone mineral density. The decreased serum 25(OH)D was prevented in the NWD2 group. After 32 wk, the NWD1 group compared with controls reduced overall energy expenditure by 15% without altering food consumption or ...
In the context of the global prevalence of vitamin D insufficiency, we compared two key determinants of the bioavailability of 3 vitamin D forms with significant biopotencies: cholecalciferol, 25-hydroxycholecalciferol and 1-α-hydroxycholecalciferol. To this aim, we studied their incorporation into synthetic mixed micelles and their uptake by intestinal cells in culture. Our results show that 1-α-hydroxycholecalciferol was significantly more solubilized into mixed micelles compared to the other forms (1.6-fold and 2.9-fold improvement compared to cholecalciferol and 25-hydroxycholecalciferol, respectively). In Caco-2 TC7 cells, the hydroxylated forms were taken up more efficiently than cholecalciferol (p | 0.05), and conversely to cholecalciferol, their uptake was neither SR-BI(Scavenger-Receptor class B type I)- nor NPC1L1 (NPC1 like intracellular cholesterol transporter 1)-dependent. Besides, the apical membrane sodium-bile acid transporter ASBT (Apical Sodium-dependent Bile acid Transporter) was
PubMed journal article Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adult were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [9]. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake [9]. Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 [9]. Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use [Read more Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [9]. Both the endogenous form of vitamin D (that ...
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: ...
Vitamin D Softgels 1,000 IU (Cholecalciferol)Sugar, Salt and Starch FreeThe benefits of Vitamin D3 run from supporting healthy bones to aiding the immune system.* D3 assists the body with calcium absorption if calcium is not absorbed properly, bodily systems in need will take it from the bones.* D3 supports the immune system* D3 strengthens breast, colon and pancreas health* One of the primary natural sources of Vitamin D is the sun, so supplementation can be essential during winter, in northern climates, and during summer if you use sunscreen. Vitamin D absorption declines with ageSuggested Use: As a dietary supplement for adults, one (1) softgel daily, preferably at mealtime, or as directed by a healthcare practitioner.Serving Size 1 SoftgelAmount Per SoftgelIngredients: Vitamin D (as cholecalciferol from fish liver oil) 1000 IU (250%)To assure freshness and potency, store in a cool, dry place, away from heat, light and moisture.Other Ingredients: Safflower Oil, Gelatin, Glycerin, Water.
in Nephrology Dialysis Transplantation (2013), 28(7), 1779-1786. Background. The role of cholecalciferol supplementation in end-stage renal disease (ESRD) patients has been questioned. The objective of this randomized double-blinded study is to assess whether ... [more ▼]. Background. The role of cholecalciferol supplementation in end-stage renal disease (ESRD) patients has been questioned. The objective of this randomized double-blinded study is to assess whether cholecalciferol therapy can increase serum 25-hydroxyvitamin D [25(OH)D] levels in haemodialysed patients and the safety implications of this therapy on certain biological parameters and vascular calcifications score. Methods. Forty-three haemodialysis patients were randomized to receive placebo or cholecalciferol (25 000 IU) therapy every 2 weeks. The biological parameters, serum calcium, phosphorus, 25(OH)D and parathormone (PTH) levels, were monitored monthly for 12 consecutive months. Vascular calcifications were assessed by ...
PRIMARY OBJECTIVES:. I. To determine the prostate-specific antigen (PSA) response with oral high dose vitamin D3 supplementation (cholecalciferol) in patients with localized, histologically proven adenocarcinoma of the prostate who have not received any treatment for prostate cancer ever and have chosen expectant management.. SECONDARY OBJECTIVES:. I. To examine the pattern of response of PSA dynamics as well as the absolute change in PSA following vitamin D3 supplementation.. II. Assess the toxicity of vitamin D3 supplementation in men with prostate cancer.. TERTIARY OBJECTIVES:. I. Track occurrence of infections, deep venous thrombosis, vascular events and falls in the study population.. II. To evaluate relationship between cytochrome P450 family 24 (CYP24), 27B1, single-nucleotide polymorphism (SNPs) and serum 25(hydroxy [OH]) vitamin D response to oral D3 supplementation.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive cholecalciferol orally (PO) once ...
Cholecalciferol, also called vitamin D-3, is a fat-soluble vitamin that is necessary for the maintenance of a healthy body. Your body makes cholecalciferol when your skin is exposed to ultraviolet rays from the sun, according to MayoClinic.com.
1 Answer - Posted in: calcitriol, cholecalciferol - Answer: No - the doses are not the same. One IU of Vitamin D (Cholecalciferol) ...
Cholecalciferol, better known as vitamin D3, is naturally produced in the skin of animals that results from a reaction to sunlight. Excessive amounts of cholecalciferol can have adverse, and even fatal effects.
To evaluate the efficacy of cholecalciferol supplementation on blood pressure control and clinical and subclinical organ damage in patients with essential
Vitamin D3 or cholecalciferol is a secosteroid nutraceutical used for the prevention and treatment of vitamin D deficiency. The objective of this study was to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of cholecalciferol using PXRD, PSA, DSC, and TGA/DTG analysis. Cholecalciferol was divided into two parts, one part of cholecalciferol was considered as control (no Biofield Treatment was provided), while second part received The Trivedi Effect® - Biofield Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The PXRD analysis exhibited that the relative intensities of characteristic diffraction peak in the Alices treated cholecalciferol were significantly altered from -28.21% to 54.16% compared with the control sample. The crystallite size of the treated sample was altered from -40.02% to 83.20% compared with the control sample. The particle size values at d10, d50, ...
Sigma-Aldrich offers abstracts and full-text articles by [Anne-Françoise Rousseau, Marguerite Foidart-Desalle, Didier Ledoux, Christophe Remy, Jean-Louis Croisier, Pierre Damas, Etienne Cavalier].
The benefits of Vitamin D3 run from supporting healthy bones to aiding the immune system.* D3 assists the body with calcium absorption if calcium is not absorbed properly, bodily systems in need will take it from the bones.* D3 supports the immune system* D3 strengthens breast, colon and pancreas health* One of the primary natural sources of Vitamin D is the sun, so supplementation can be essential during winter, in northern climates, and during summer if you use sunscreen. Vitamin D absorption declines with age Supplement Facts Vitamin D3 5000 IU 1250% as cholecalciferol Other Ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium StearateDirections As a dietary supplement for adults, take one (1) vegetable capsule daily, preferably at mealtime, or as directed by a health care practitioner. CautionIf you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Studies from our group and others have already shown that cholecalciferol supplementation is a safe way to increase 25 (OH)D concentrations in kidney transplant recipients, but the small number of treated patients included in these studies and their short follow-up do not allow any conclusion on the effect of these treatments on kidney function. Our results should encourage randomized controlled trials evaluating the effect of early cholecalciferol supplementation on renal allograft function and provide valuable information on the magnitude of the expected effects of such treatments on renal function and histologic features ...
China Supply Vitamins Food Grade CAS: 67-97-0 Vitamin D3, Find details about China Cholecalciferol, 67-97-0 from China Supply Vitamins Food Grade CAS: 67-97-0 Vitamin D3 - Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
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Vitamin D3 (Cholecalciferol) is an important nutrient responsible for regulating calcium, which contributes to the health of teeth, bones and cartilage. It may also support healthy immune function and aids in the absorption of magnesium, a mineral essenti. ...
The purpose of this study is to determine whether nutritional (cholecalciferol) or active vitamin D (calcitriol) supplementation improves vascular endothelial function in patients with stage IIIB and IV chronic kidney disease with vitamin D insufficiency or deficiency. The investigators hypothesize that the use of calcitriol supplementation will result in improved vascular endothelial function as compared to cholecalciferol supplementation ...
Cholecalciferol is a form of vitamin D thats synthesized by the skin after exposure to sunlight. Its also added to many foods as...
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A 2014 multicenter study of the proven relationship between hormone Vitamin D deficiency and obesity, at the University of Oulu Oulu Institute of Biomedicine in Finland, The University of South Adelaide in Australia, University College London in the UK, and the Imperial College London in the UK, found that a higher BMI was causally related to lower cholecalciferol (D(25(OH)D), but that no immediate effect was achieved with cholecalciferol supplementation. The Vitamin D3 hormone receptor was central to many metabolic effects associated with obesity, though, and that active D3, or calcitriol, was produced by the fat cells, and was integral to regulation of the inflammatory mediators in the fat cells. Therefore, these studies showed clearly that deficient modulation of fat cell inflammatory processes contributed heavily to increased growth of fat cells, and this was directly linked to hormone Vitamin D deficiency, but that these effects were non-linear and dependent on a large array of other ...
Methods This was a randomised controlled trial, double blind study. Forty SLE patients with hypovitamin D were studied, that randomised into two groups: 20 patients (supplementation group) received vitamin D (cholecalciferol 1200 IU daily) with curcumin 20 mg (three times daily); and 20 patients (placebo group) was given vitamin D (cholecalciferol 1200 IU daily) and placebo (3 times daily), for 3 months. Anti-ds DNA serum levels were measured by ELISA and urine protein were measured by urine albumin creatinine ratio (UACR). ...
Difficulties in establishing requirements for vitamin D arise from the limited number of food sources available, lack of knowledge of precise body needs, and degree of synthesis in the skin by irradiation. The amount needed can vary between winter and summer in northern climates. In addition, life-style determines the degree of exposure to sunlight and would therefore influence individual need. This is especially true of the elderly and invalids who do not go outside and therefore may need supplementary vitamin D. Growth demands in childhood, during pregnancy, and during lactation necessitate increased intake. The daily recommendation for young adults is 7.5 mcg and older adults 5.0 mcg. The RDA standard is 10 mcg, or 400 international units (IU), of cholecalciferol daily for children and for women during pregnancy and lactation. One IU of vitamin D is equivalent to biologic activity of 0.025 mcg of pure crystalline vitamin D-3 (cholecalciferol). Adults over 22 years of age need only a small ...
To the Editor:. An 84-year-old woman with a history of surgical menopause at the age of 37 years, gastroesophageal reflux disease, and prolonged corticosteroid use (prescribed by her general pratictioner for osteoarthritis-related pain), sustained a low-trauma vertebral fracture at L3 level. Radiographs showed previous L2 fracture. Other investigations were unremarkable, except for low 25-OH vitamin D levels (22.1 ng/ml) and elevated plasma parathyroid hormone (144 pg/ml). She was then diagnosed with osteoporosis, supplemented with 300,000 IU of oral cholecalciferol, and started therapy with neridronic acid (NA), 100 mg intravenously1. Corticosteroids had been tapered before starting NA. The day after her first NA dose, she noticed polyarthralgia, myalgia, and fever (to 38°C). Over the subsequent 5 days, symptoms eased, but she experienced progressive pain and swelling of her left shoulder. Pain was severe and she was unable to lift her left arm for activities of daily living. She came to ...
Vitamin D is a fat-soluble vitamin that is required to promote calcium absorption, which helps to maintain healthy bones and teeth. Vitamin D also supports a healthy immune system and the health of various tissues such as those of the breast and colon. Th
Vitamin D is required to promote calcium absorption, which helps to maintain healthy bones and teeth.Vitamin D also supports a healthy immune system and ne
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Vitamine D information about active ingredients, pharmaceutical forms and doses by Gamme Nature, Vitamine D indications, usages and related health products lists
According to a new mouse study, exposure to vitamin D during pregnancy may prevent autistic traits in offspring.... Read More... ...
For professional use only. Imprimis Pharmaceuticals specializes in customizing medications to meet unique patient and practitioner needs. Imprimis Pharmaceuticals dispenses only to individually identified patients with valid prescriptions. No compounded medication is reviewed by the FDA for safety or efficacy. Imprimis Pharmaceuticals does not compound copies of commercially available products. References available upon request.. ...
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There arent words to describe that feeling when you leave your house and start riding, to realise halfway through that you dont have a jacket on, and frankly, you dont care; the sun has graced us with its presence over the last week and it has been wonderful! Most of the weekend was spent at…
On occasion, horses will come into contact with horse feed that has been contaminated with cholicalciferol, an active ingredient in many types of rat poison. Learn the signs of this type of poisoning and the common ways to treat it.
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Part of the secret to strong bones is to have enough vitamin D in your blood. Ergocalciferol, or vitamin D-2, and cholecalciferol, or vitamin D-3, are two...
The body does make its own vitamin D-3. Vitamin D-3, also called cholecalciferol, is made in the skin of human beings from a compound called...
The details for batch #SB008029 of 1,000 IU vitamin D3. Sourced as cholecalciferol from a GMP facility in Dallas, Texas and made in California.
Product Detail Product Description Vitamin D3 Injection, all strengths and all presentations including a) Cholecalciferol D3 50,000iu 30 mL, b) Calcitriol D3 10,000iu, and c) Calcitriol D3 50,000iu Rx only, Green Valley Drugs, 1850 Whitney Mesa, #180, Henderson, NV 89014. Recall
erm k ltal nos le r sa A Vitamin D3 (cholecalciferol) az eg szs ges csontozathoz fontos a megfelel mennyis g bevitele, kit ntetett szerepe van m g
Dr. Cannells Advanced D with Calcium and Magnesium provides a powerful dose of cholecalciferol (Vitamin D3) backed by nutrients that work in tandem with this crucial vitamin to support the health of numerous systems within the body.
Natural Antacid* Natural Spearmint Flavor Sodium and Aluminum Free ONE TABLESPOON CONTAINS AMOUNT Calories 10 Calories From Fat 0 Calcium (Carbonate) 600 mg Vitamin D3 (Cholecalciferol) 120 IU Magnesium (Oxide) 300 mg
Methods : Five-wk old C57BL/6N mice were divided into 4 groups and fed diets differ in fat amount (10 or 45% kcal fat: CON or HFD) and vitamin D content (1,000 or 10,000 IU/kg of diet: DC, or DS) for 13 wks. Subpopulation of immune cells (macrophage, NK cell, CD 4 T cell, CD 8 T cell, B cell) from adipose tissue-derived SVC was determined by FACS analysis. Five-wk old C57BL/6 mice were fed control or HFD diets (10 or 60% kcal fat, CON or HFD) for 12 wks. Adipocytes and SVC, isolated from visceral adipose tissue, were cultured with or without 10 nM of 1,25(OH)2D3 for 48 h and stimulated with LPS during the last 24 h. Pro-inflammatory cytokines produced by SVC and adipocytes were measured by ELISA. The mRNA levels of Tlr2, Tlr4, Dusp1, and Dusp10 were determined in SVC by real-time PCR.. ...
Q2. 80% of healthy populations of South Asia are Vitamin-D deficient. For these patients, Beximco Pharma has the D-lightful health solution "Cholecalciferol" as 40 ¸000 IU capsule¸ 20¸000 IU capsule & 2¸000 IU tablet. Which one is the brand name of these preparations ...
I get a lot of concerns about supplements even though I am not a huge proponent of them. It really is awful, he is in so much pain, but cant stop the pain because he cant cease throwing up. So, I took him to ER once again (still no insurance), we went by way of the exact same factor as last time, and they sent us away. Heather, it is so nice to hear from a person that has an older dog with a mild case. Supplementing with added cholecalciferol is inexpensive and easy, but I am asking this question simply because a neighbor of mine lately purchased a stand-up tanning lamp from a business called Sunsplash and presented me access to it for the duration of the Winter. Physicians told that he has a year and half development delay, but he has no troubles mentally. Prior to ordering something accessible on the present market, researching has to be accomplished by the consumer. The greatest moment in the history of supplements came on September 1, 1998. Most individuals with CFS/ME who routinely take ...
There are 30 fifteen-letter words containing A, 2C, E and F: CAPRIFOLIACEOUS CERTIFICATORIES CHOLECALCIFEROL ... RECODIFICATIONS SPEECHIFICATION SUBSPECIFICALLY. Every word on this site is valid scrabble words. See other lists, that start with or end with letters of your choice.
MegaFood Vitamin D-3 1000 IU DailyFoods provides 100% whole food Vitamin D-3 that promotes healthy immune function, strong bones and hormonal production.
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1,000 IU / 45 mcg Plus Cardiovascular Support* NOW combines two nutrients extensively researched for their contribution to the health of bones, teeth and the ca
Calcium/cholecalciferol is a combination of a calcium salt (usually calcium carbonate) and vitamin D3 (cholecalciferol), available under many brand names and in many forms such as chewable tablets, coated tablets, and effervescent tablets. It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well as adjunctive therapy for osteoporosis. Possible side effects include gastrointestinal problems, for example nausea and constipation. If very high doses are taken, signs of hypercalcaemia (too high blood calcium levels) have been described, such as stomach pain, vomiting, thirst, and tiredness. Extreme or long-term or overdose can theoretically result in hypervitaminosis D, kidney stones, renal insufficiency and calcinosis. Calcium forms complexes with a number of pharmaceutical drugs, reducing their bioavailability; among them are tetracyclines, quinolone antibiotics, levothyroxine, and bisphosphonates, as well as iron, magnesium and zinc supplements. Vitamin D in usual ...
ment of serum 25-OH-vitamin D (25(OH)D) and serum calcium will help to ensure that vitamin D levels are safe and effective for health maintenance and disease prevention. Clinical research supporting the use of vitamin D in the management of type 2 diabetes, osteoporosis, osteoarthritis, hypertension, cardiovascular disease, metabolic syndrome, multiple sclerosis, polycystic ovary syndrome, musculoskeletal pain, depression, epilepsy, and the prevention of cancer and type 1 diabetes is presented along with our proposal for the interpretation of serum 25(OH)D laboratory values.. Basic Physiology of Vitamin D. Vitamin D is obtained naturally from two sources: sunlight and dietary consumption. Vitamin D3 (cholecalciferol) is the form of vitamin D produced in the skin and consumed in the diet. Vitamin D2 (ergocalciferol), which is produced by irradiating fungi, is much less efficient as a precursor to the biologically active 1,25-dihydroxyvitamin D (calcitriol). Additionally, since ergocalciferol ...
Calcium / Vitamin D Calcium metabolism • Serum calcium drops.. PTH released.. • In kidney, PTH turns vitamin D into its active form 1,25hydroxycholecalciferol (calcitriol)... It also increases kidneys reabsorption of calcium from urine • Calcitriol acts to aid absorption of calcium from small intestine Calcium metabolism • Dietary sources - Dairy (semi skimmed milk greater content than full fat), sardines, bread, baked beans, cabbage • PTH causes release of calcium from bone into bloodstream. • Absorption of calcium from blood into bone matrix, stimulated by calcitriol Vitamin D metabolism • Vitamin D is produced by the skin in sunlight (cholecalciferol - D3) • Diet adequate in vitamin D is needed to maintain supplies in Winter (D2 and D3) • Dietary sources: - Eggs, dairy products, oily fish, fortified cereals • Skin and dietary sources of vitamin D are metabolised by liver and then kidney, into active form 1,25hydroxycholecalciferol (calcitriol) Vitamin D deficiency • ...
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Dr. Mansour Al Zahrani National Guard Program - Riyadh 2009/2010 The aim of the current study was to determine whether oral cholecalciferol (45000 IU) per week for the 2 months and once on the 3rd month could translate to full vitamin D status correction and improved metabolic profile among patients with suboptimal vitamin D…
Vitamin D3 (cholecalciferol) is an essential vitamin supplement which is to improve overall health and preferably to treat osteoporosis. Natural form of Vitamin D 60000 IU (Cholecalciferol Sublingual Granules) Instant melts for rapid recovery. Vitamin D3 (cholecalciferol) supplement, treat osteoporosis, Vit. D3 Online, Natural vitamin D3 formulas, buy Vitamin D3, organic Vitamin D3 Complex, Vitamin D3 nutrient, super Strength Vitamin D3, supplementing with D3, vitamin D3 sachets, Vitamin D3 granules, vitamin D3 stabilized, vitamin D3 (Generic Drug), Vitamin D3 60, 000 IU/1g, Vegan and Vegetarian Vitamin D3 Supplement. Vitamin D supplement manufacturers, Vitamin D supplement suppliers, Vitamin D supplement exporters wholesalers, traders in Chennai, India. ; Get more Updates and offers, Contact, Address, Location, Maps for BioShope;
It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination. If you are having a dental procedure while taking this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe bone, joint, or muscle pain while using this medicine. This medicine could lower the amount of calcium in your blood. Call your doctor right away if you develop any signs of low calcium levels, such as muscle spasms or twitching, or numbness or tingling in your fingers, toes, or lips. This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips. Do not take other medicines unless they have been discussed with your doctor. This ...
RATIONALE: The use of cholecalciferol and calcium carbonate may keep colon cancer from coming back in patients with colon cancer that has been removed b
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Patient Information FOSAMAX PLUS D (FOSS-ah-max PLUS D) (alendronate sodium/cholecalciferol) Tablets Read the patient information before you start taking FOSAMAX PLUS D 1. Also, read the leaflet each time
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The decreasing of glucose transporter 4 (GLUT 4) in adipose tissue of diabetic and obesity patients are associated with hyperinsulinaemia and insulin resistance. The adipose tissue can be used as therapeutic targets in the treatment of Diabetes Mellitus (DM). Visceral adipose tissue has different morphology and functional with subcutaneous adipose tissue and Vitamin D has been known to have contributed in DM. The aim of this study is to know the role of cholecalciferol on the expression of GLUT 4 in subcutaneous and visceral adiposity of diabetic rats by elucidated in those tissues. The subjects of the study consisted of nineteen male diabetic rats of Wistar strain, which were divided into control group (K) and three (3) treatment groups (X1, X2 and X3). In order to induce the condition of DM, the animals were fed with high fat diet for three (3) weeks and administered a single intraperitoneal injection of streptozotocin (35 mg/kgBW) at the end of the second week. Cholecalciferol were administered with
For several years Cholecalciferol has been available from several pharmaceutical and nutraceutical companies worldwide. However its industrial scale production for use in vitamin supplements has been largely unchanged. Cholecalciferol is generally produced by the ultraviolet irradiation of 7-dehydrocholesterol extracted from lanolin found in sheeps wool. However this process leaves behind some unwanted isomers are formed during irradiation which can affect physical stability and alter potency.. Entod International however, have developed and designed an innovative technique to produce Vitamin D3 at its state-of-the-art plant in Europe which results in the production of the purest and most physically stable form of cholecalciferol. This novel form contains no isomers and therefore maintains its potency throughout the shelf-life of the product.. ...
A double-blinded, placebo-controlled interventional trial reveals high-dose vitamin D3 as a potent modulator of experimental sunburn induced by simulated solar radiation.
Feminine and Man C57Bl6 mice were fed a control AIN76A diet plan, a fresh Western-style diet plan (NWD1) reflecting diet patterns associated with elevated cancer of the colon incidence (higher body fat, lower cholecalciferol, calcium mineral, methyl donors, fiber), or NWD1 with elevated cholecalciferol and calcium mineral (NWD2) from weaning. and improved serum concentrations from the proinflammatory cytokine IL-1, and of its focuses on, MCP-1 and Rantes, that have been prevented or mitigated in the NWD2 group greatly. However, there is also raised lipid storage space in the liver organ and steatosis not really observed in the control and NWD1 organizations. Thus, elevating calcium mineral and cholecalciferol inside a Western-style diet plan can decrease swelling connected with risk for digestive CGP 60536 tract tumor advancement, but discussion of nutrition in the dietary plan can compromise liver organ function when given long term. Intro Newmark, Lipkin, and co-workers (1C4) designed ...
The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.. This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3 18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and creatinine were measured before and after 3 mo (54 pts), 6 mo (27 pts), 9 mo (15 pts), 12 mo (25 pts), 18 mo (5 pts) of oral vitamin D supplementation.. At baseline, using a cut-off point of sufficiency of 30 ng/ml, 10.34% of patients were deficient (mean=7.77 ng/ml), 82.76% were insufficient (mean=16.19 ng/ml) and 6.9% were sufficient (mean=35.86 ng/ml).. After 3 months of supplementation none of the patients was deficient, 64.81% were insufficient (mean=22.91 ng/ml) and 35.19% were sufficient (mean=36.79 ng/ml). The increment in serum 25OHD was ...
Vitamin D is called the sunshine vitamin because we can usually get it from the suns ultraviolet rays. It supports bone development and is needed for calcium and vitamin C absorption, and it supports the nervous system. Vitamin D plays a dual role as both a vitamin and a hormone that stimulates the body to absorb calcium. 180 tablets. 1000 IU Cholecalciferol (1000 IU) in a tablet. 1 tablet daily or as directed.
25-Hydroxyvitamin D2 and D3 (25-OH-VitD) are steroid hormones that require 1-alpha-hydroxylation before expressing biological activity. Vitamin D compounds are derived from dietary ergocalciferol (from plants, VitD2) or cholecalciferol (from animals, VitD3), or by conversion of 7-dihydrocholesterol to VitD3 in the skin upon ultraviolet exposure. VitD2 and VitD3 are subsequently 25-hydroxylated in the liver to 25-OH-VitD. 25-OH-VitD represents the main body reservoir and transport form of vitamin D, being stored in adipose tissue and tightly bound by a transport protein while in circulation. A fraction of circulating 25-OH-VitD is converted to its active metabolites 1,25-dihydroxy vitamin D2 and D3 (1,25-OH-VitD), mainly by the kidneys. This process is regulated by parathyroid hormone (PTH), which increases 1,25-OH-VitD synthesis at the expense of the alternative, biologically inactive hydroxylation product 24,25-OH-VitD. Like other steroid hormones, 1,25-OH-VitD binds to a nuclear receptor, ...
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heartburn, anemia, blood clotting problems, ulcers or other stomach or bowel problems, sarcoidosis, a vitamin D deficiency, or a history of leukemia, lymphoma, or other cancer. Tell your doctor if you have dental problems or if you wear dentures. Also tell your doctor if you smoke or drink alcohol ...
Briozcal information about active ingredients, pharmaceutical forms and doses by Bridge Healthcare, Briozcal indications, usages and related health products lists
Vitamin D" refers to two biologically inactive precursors: D3 (cholecalciferol) and D2 (ergocalciferol). Both precursors are transformed in the liver and kidneys into 25-hydroxyvitamin D (25(OH)D, the non-active storage form, and the compound measured to assess vitamin D status). 25(OH)D is further converted to 1,25-dihydroxyvitamin D (1,25(OH)2D, the biologically active form) in a process thats tightly controlled by the body ...
Visite a su médico o a su profesional de la salud para chequeos periódicos. Puede ser necesario que transcurra cierto tiempo antes de que pueda observar los beneficios de este medicamento. No deje de tomar su medicamento excepto si así lo indica su médico. Su médico o su profesional de la salud puede pedirle análisis de sangre u otros exámenes para chequear su evolución.. Asegurarse de que su dieta incluya la cantidad necesaria de calcio y vitamina D mientras esté tomando este medicamento. Hable con su profesional de la salud acerca de sus alimentos y las vitaminas que esté tomando.. Si tiene dolor al tragar, dificultad para tragar, acidez de estómago o dolor estomacal, comuníquese con su médico o su profesional de la salud inmediatamente.. Si está tomando un antiácido, suplemento mineral como calcio o hierro, o una vitamina con minerales espere por lo menos 30 minutos después de tomar este medicamento para tomarlos. No los tome a la misma vez.. Este medicamento puede aumentar la ...
Im in, John. Going for a bit of weight loss but really just overall fitness. You say you want to cut 50% of your calories. Im curious what kinda calorie intake you have overall.. I think it would be nice to include daily vitamins along with 5000 IU daily Vitamin D3(cholecalciferol) to the list. Coming out of the winter were all really low on D3 and Ive seen how much sun you get (or dont get). You should go get blood work done before and after the workout to really show you how much your diet changes your body. Its not very expensive. Its not just the outward appearance thats important. Here are links for good vitamins. 5000 IU Vitamin D3 on Amazon: http://www.amazon.com/NOW-Foods-Vitamin-5000-Softgels/dp/B0032BH76O/ref=sr_1_1?ie=UTF8&qid=1303745247&sr=8-1. GNC Mega Men Sport: http://www.gnc.com/product/index.jsp?productId=4033435. ...
Vitamin D3 5000 IU by Seeking Health is a pure and potent vitamin D3 supplement in a vegetarian capsule that provides 5000 IU of cholecalciferol. Many people do not get sufficient vitamin D3 in their diet, and the synthetic vitamin D2 that is often added
Vitamin D is included in most multivitamins, usually in strengths from 50-100 international units (IU). It can be found as softgels, capsules, tablets, and liquids. The new 2010 recommended daily allowance (RDA) is 600 IU for those 1-70 years of age and pregnant or breastfeeding women, and 800 IU for those over 71 years of age. An adequate blood level of vitamin D is 20 nanograms per milliliter, which can be achieved through daily skin exposure to sunlight. Levels over 50 nanograms per milliliter may cause side effects.. For osteomalacia caused by anti-seizure drugs, 2,000 IU of vitamin D2 and 390 milligrams of calcium lactate have been taken by mouth daily for three months.. For atopic eczema, 1,600 IU of cholecalciferol has been taken by mouth alone or with 600 IU man-made all-rac-alpha-tocopherol, daily for 60 days.. For autoimmune diseases, 0.25-2 micrograms of alfacalcidol has been taken by mouth 1-2 times daily and 0.5 micrograms of 1-alfa-OH D3 has been taken by mouth daily for up to 12 ...
The VDR gene (contained in every cell of the body) provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body by exposure to from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth. One of vitamin Ds major roles is to control the absorption of calcium and phosphate from the intestines into the bloodstream. Vitamin D is also involved in several process unrelated to bone formation.. VDR attaches (binds) to the active form of vitamin D, known as calcitriol. Calcitrol is produced in the body from Vitamin D3 (cholecalciferol) in the liver and kidneys. The interaction with calcitriol allows VDR to partner with another protein called retinoid X receptor (RXR). The resulting complex of proteins then binds to ...
Jarrow Formulas Vitamin D3 provides cholecalciferol, the most bioavailable form of vitamin D. Vitamin D3 is convertedby the kidneys into the hormone calcitriol,
Doctors Best - Best Vitamin D3 5000 IU 180 Softgel Capsules Doctors Best Vitamin D3 cholecalciferol is a nutrient that is critical to many bodily functions. Doctors Best Best Vitamin D3 is beneficial for supporting bone health immune wellness cardio- vascular function and cellular metabolism am
Vitamin D3. Molecular model of cholecalciferol (C27.H44.O), also known as vitamin D3 and toxiferol. This vitamin (actually a prehormone) can be synthesized in the body when sun exposure is adequate. The active form, calcitriol, regulates the synthesis of hundreds of enzymes. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white) and oxygen (red). Illustration. - Stock Image F017/0124
While a kidney transplant can restore healthy kidney function, recipients remain at increased risk of fractures, heart disease, diabetes and some cancers. The VITALE study shows that, compared with currently recommended doses, high doses of oral vitamin D (cholecalciferol) lower the risk of fractures, but have no effect on the risks of heart disease, diabetes or cancer after a kidney transplant.
Learn more about Vitamin D at Memorial Hospital Supplement Forms/Alternate Names Cholecalciferol (Vitamin D 3 ) ...
CK IN FAVOUR. According to labelling. regulations in the EU,. eggs qualify as a source. of Vitamin A, folate,. choline, phosphorus. and selenium, and are rich in Vitamin D,. riboflavin, Vitamin B12, biotin and iodine.. The high Vitamin D content of eggs is. noteworthy given the current interest in. Vitamin D insufficiency in the UK.. An average egg (58g) contains just 66. calories but their protein content is high. at 4.5g per medium egg. That means. that one egg represents about 10%. of an adults daily protein requirement.. Eggs have long been acknowledged as. a healthy, food but studies now point. towards benefits for weight management,. most recently from a trial presented in. 2012 European Congress of Obesity.. Eggs are related to weight. management because certain nutrients. such as protein, fibre, novel oils and nondigestible carbohydrates are. believed to. useful for weight management due to their. affect on satiety (defined as a feeling of. fullness after eating). An enhanced ...
Jarrow Formulas® Vitamin D3 provides cholecalciferol, the most bioavailable form of vitamin D. Vitamin D3 is converted by the kidneys into the hormone calcitriol, the active form of vitamin D3. Vitamin D3 enhances calcium and phosphorous absorption, stimulates the synthesis of osteocalcin (an important structural protein in bone), and supports a healthy immune response.. ...
Vitamin D3, otherwise known as cholecalciferol, is a fat-soluble vitamin and essential nutrient produced in the skin when exposed to sunlight.
Researchers have adviced pregnant women to consume Vitamin D supplements during pregnancy as it is considered safe as well as protective.
Synonyms for ergosterol in Free Thesaurus. Antonyms for ergosterol. 8 words related to ergosterol: steroid alcohol, sterol, calciferol, cholecalciferol, D, ergocalciferol, viosterol, vitamin D. What are synonyms for ergosterol?
Synonyms for DEES in Free Thesaurus. Antonyms for DEES. 9 synonyms for D: calciferol, cholecalciferol, ergocalciferol, viosterol, vitamin D, 500, five hundred, 500, five hundred. What are synonyms for DEES?
Supply your body with a multivitamin with increased vitamin and mineral support plus 5-MTHF folate with Basic Maintenance Plus Vitamin D 120 capsules.
in Burns : Journal of the International Society for Burn Injuries (2015), 41(5), 1028-1034. Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a ... [more ▼]. Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a cholecalciferol (VD3) bolus on VD status in adult burn patients (Group B, GB) after admission, compared to healthy subjects (Group H, GH). Methods: Both groups received an oral dose of 100,000 IU VD3. Blood samples were collected before (D0) and 7 days (D7) after bolus to measure 250H-D, 1,25(OH)2-D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). Albumin (ALB) and VD binding protein (DBP) were measured and used to calculate free 25OH-D level. Data were expressed as median (min-max) or ...
Jointace? Original has beendeveloped by Vitabiotics nutritional experts and provides unique combinations oftrace minerals, vitamins and nutrients, ideal for those with an active life, insport or in later life. Along with trace minerals for extra nutritionalsupport, Jointace? Original provides Glucosamine present in the preferredpotassium form, and a high quality LMW (low molecular weight) form ofChondroitin, together with Ginger Root extract, a well-known botanicalingredient. Copper contributes to the maintenance of normal connectivetissues and therefore can be beneficial to cartilage (as cartilage is made up ofconnective tissues). Vitamin D3, zinc and manganese all help tomaintain normal bone. Vitamin D3 is provided in its Cholecalciferol form asnaturally produced by the body on exposure to sunlight. Vitamin Ccontributes to normal collagen formation for the normal function of bones andcartilage.
... Vitamins Because Your Worth It is your Pure choice for quality discount vitamins, minerals, herbs and nutritional supplements
... is one of the five forms of vitamin D.[25] Cholecalciferol is a secosteroid, that is, a steroid molecule with ... pre-cholecalciferol).[28] In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] ... Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin, found in some ... "cholecalciferol" at Dorland's Medical Dictionary. *^ "About Vitamin D". University of California, Riverside. November 2011. ...
... cholecalciferol); and adipose tissue (leptin and resistin). Endocrine glands derive from all three germ layers.[citation needed ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Ergocalciferol and Cholecalciferol (Vitamin D). *Tocopherol (Vitamin E). *Naphthoquinone (Vitamin K). *Calcium ...
In soils, it is assumed that larger amounts of phenols are released from decomposing plant litter rather than from throughfall in any natural plant community.[citation needed] Decomposition of dead plant material causes complex organic compounds to be slowly oxidized lignin-like humus or to break down into simpler forms (sugars and amino sugars, aliphatic and phenolic organic acids), which are further transformed into microbial biomass (microbial humus) or are reorganized, and further oxidized, into humic assemblages (fulvic and humic acids), which bind to clay minerals and metal hydroxides.[citation needed] There has been a long debate about the ability of plants to uptake humic substances from their root systems and to metabolize them.[citation needed] There is now a consensus about how humus plays a hormonal role rather than simply a nutritional role in plant physiology.[citation needed] In the soil, soluble phenols face four different fates. They might be degraded and mineralized as a carbon ...
Cholecalciferol#. *25-hydroxycholecalciferol. *Calcitriol (1,25-dihydroxycholecalciferol). *Calcitroic acid. *D4 * ...
The first use of rubber was by the indigenous cultures of Mesoamerica. The earliest archeological evidence of the use of natural latex from the Hevea tree comes from the Olmec culture, in which rubber was first used for making balls for the Mesoamerican ballgame. Rubber was later used by the Maya and Aztec cultures - in addition to making balls Aztecs used rubber for other purposes such as making containers and to make textiles waterproof by impregnating them with the latex sap.[6][7] The Pará rubber tree is indigenous to South America. Charles Marie de La Condamine is credited with introducing samples of rubber to the Académie Royale des Sciences of France in 1736.[8] In 1751, he presented a paper by François Fresneau to the Académie (published in 1755) that described many of rubber's properties. This has been referred to as the first scientific paper on rubber.[8] In England, Joseph Priestley, in 1770, observed that a piece of the material was extremely good for rubbing off pencil marks on ...
Cholecalciferol in vegan dog food can be synthetic or naturally derived from lichen, a non-animal source of D3. Vitamin B12 is ... Cholecalciferol is then converted to calcidiol in the liver before further hydroxylated to calcitriol, the active form of ... However, the conversion of provitamin D to cholecalciferol is significantly lower in dogs than other mammals, and is not ... In the diet, there are two forms of vitamin D - cholecalciferol (vitamin D3) from mainly animal sources, and ergocalciferol ( ...
The prototypical secosteroid is cholecalciferol (vitamin D3). Some nonsteroidal estrogens, like doisynolic acid and allenolic ...
Cholecalciferol is also a highly toxic agent. The anticoagulants, indandiones and red squill, are less hazardous to humans and ...
0.15% cholecalciferol bait appears to have application for pocket gopher control.' Cholecalciferol can be a single high-dose ... Cholecalciferol differs from conventional acute rodenticides in that no bait shyness is associated with consumption and time to ... Cholecalciferol is an acute (single-feeding) and/or chronic (multiple-feeding) rodenticide toxicant with unique activity for ... Rizor, Suzanne E.; Arjo, Wendy M.; Bulkin, Stephan; Nolte, Dale L. Efficacy of Cholecalciferol Baits for Pocket Gopher Control ...
Cholecalciferol is more expensive to produce than 1080. Some promising results have been obtained by combining cholecalciferol ... Cholecalciferol naturally occurs as vitamin D3 in many foods, including fish. It was developed as a poison to control rats and ... Cholecalciferol will reduce populations of possums and rats, but not stoats, since it does not bioaccumulate in animals. It ... Cholecalciferol is very inhumane. Para-aminopropiophenone (PAPP) was developed to control stoats, weasels, and feral cats, and ...
van Groningen L, Opdenoordt S, van Sorge A, Telting D, Giesen A, de Boer H (April 2010). "Cholecalciferol loading dose ...
... synthesized endogenously in the liver in form of Cholecalciferol. The endogenous inactive form of Vitamin D is Cholecalciferol ...
Bothra, Meenakshi; Gupta, Nandita; Jain, Vandana (2016-06-01). "Effect of intramuscular cholecalciferol megadose in children ...
"Cefoxitin and cholecalciferol / genistein / zinc chelazome Drug Interactions - Drugs.com". Drugs.com. Retrieved 2017-05-29. " ...
Only a few foods contain vitamin D. The major natural source of the vitamin is synthesis of cholecalciferol in the skin from ... The two major forms are vitamin D2 or ergocalciferol, and vitamin D3 or cholecalciferol; vitamin D without a subscript refers ... In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 ( ... Cholecalciferol is converted in the liver to calcifediol (25-hydroxycholecalciferol); ergocalciferol is converted to 25- ...
True polyphenols from the tannin and other WBSSH types are routinely biosynthesized in the natural sources from which they derive; their 'chemical' syntheses (using standard "bench" organic chemical methods) were somewhat limited until the first decade of the new millennium because these syntheses involve challenging regioselectivity and stereoselectivity issues.[11] Early work focused on the achiral synthesis of phenolic-related components of polyphenols in the late 70's,[12] and the Nelson and Meyers synthesis of the permethyled derivative of the ubiquitous diphenic acid core of ellagitannins in 1994[13] followed by stereoselective synthesis of more complex permethylated structures such as a (+)-tellimagrandin II derivative by Lipshutz and coworkers in the same year,[14] and Itoh and coworker's synthesis of a permethylated pedunculagin with particular attention to axial symmetry issues in 1996.[15] The total synthesis of a fully unmasked polyphenol, that of the ellagitannin tellimagrandin I, ...
Cholecalciferol. Steroidal. ,0.01. ,0.2. ,0.1. ,0.1 Cimetidine. Nonsteroidal. ,0.01. ,0.2. ,0.1. ,0.1 ...
"Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol". Am J Clin Nutr. 77 (1): 204-10. ...
Cholecalciferol produces hypercalcemia, which results in systemic calcification of soft tissue, leading to renal failure, ... The Merck Veterinary Manual states the following: Although this rodenticide [cholecalciferol] was introduced with claims that ... Today, Sorexa CD contains a 0.0025% difenacoum and 0.075% cholecalciferol combination. Numerous other brand products containing ... cholecalciferol and 0.1% ergocalciferol when used alone, which can kill a rodent or a rat. There is an important feature of ...
Vitamin D3 (cholecalciferol) is typically absorbed more readily than vitmin D2 (ergocalciferol). Osteomalacia due to ...
... is an intermediate in the production of cholecalciferol (vitamin D3). It is formed by the action of UV light, ... It then undergoes spontaneous isomerization into cholecalciferol, the prohormone of the active form of vitamin D, calcitriol. ...
Mouse and rat poisons containing cholecalciferol cause hypercalcemia and hyperphosphatemia in dogs. Clinical signs include ...
Vitamin D3 (cholecalciferol) is the preferred form since it is more readily absorbed than vitamin D2. Most dermatologists ...
Cholecalciferol is one of the five forms of vitamin D.[30] Cholecalciferol is a secosteroid, that is, a steroid molecule with ... 0.15% cholecalciferol bait appears to have application for pocket gopher control. Cholecalciferol can be a single high-dose ... We investigated the effect of oral high-dose cholecalciferol on plasma and adipose tissue cholecalciferol and its subsequent ... Cholecalciferol is available as a generic medication and over the counter.[4] Cholecalciferol is also used at much higher doses ...
Cholecalciferol is one of the five forms of vitamin D.[25] Cholecalciferol is a secosteroid, that is, a steroid molecule with ... pre-cholecalciferol).[28] In a process which is independent of UV light, the pre-cholecalciferol then undergoes a [1,7] ... Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D which is made by the skin, found in some ... "cholecalciferol" at Dorlands Medical Dictionary. *^ "About Vitamin D". University of California, Riverside. November 2011. ...
Calcium/cholecalciferol is a combination of a calcium salt (usually calcium carbonate) and vitamin D3 (cholecalciferol), ...
Easy to read patient leaflet for Cholecalciferol Sublingual Spray. Includes indications, proper use, special instructions, ... What do I need to tell my doctor BEFORE I take Cholecalciferol Sublingual Spray?. *If you have an allergy to cholecalciferol or ... Vitamin D Insufficiency cholecalciferol, Vitamin D3, Replesta, More.... Prevention of Falls cholecalciferol, Vitamin D3, ... What are some things I need to know or do while I take Cholecalciferol Sublingual Spray?. *Tell all of your health care ...
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Easy to read patient leaflet for Cholecalciferol Capsules and Tablets. Includes indications, proper use, special instructions, ... Cholecalciferol Capsules and Tablets. Generic Name: Cholecalciferol Capsules and Tablets (kole e kal SI fer ole). Brand Name: D ... Vitamin D Insufficiency cholecalciferol, Vitamin D3, Replesta, More.... Prevention of Falls cholecalciferol, Vitamin D3, ... If you have an allergy to cholecalciferol or any other part of this medicine (cholecalciferol capsules and tablets). ...
A Major Drug Interaction exists between paricalcitol and cholecalciferol. View detailed information regarding this drug ... cholecalciferol. Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic ... Using cholecalciferol together with paricalcitol should generally be avoided unless otherwise directed by your doctor. Both of ...
Cholecalciferol is a form of vitamin D thats synthesized by the skin after exposure to sunlight. Its also added to many foods ... Cholecalciferol, also called vitamin D3 or calciol, is a form of vitamin D, and is synthesized by the skin after exposure to ... In the liver, cholecalciferol is metabolized into calcifediol, which is further modified in the kidneys to become calcitriol. ... Both deficiency and excess of cholecalciferol or other forms of vitamin D can cause disease. Deficiency in vitamin D, also ...
... also known as Cholecalciferol, helps absorb calcium which is essential for signaling between brain cells, development of bone, ... Scientific Name: Cholecalciferol. Benefits: Teeth, bones, clotting. Daily Needs (Adult): 15 - 20mcg. Daily Needs (Child): 10 - ... All about Vitamin D (Cholecalciferol). Vitamin D Facts:. Vitamin D helps the body absorb the mineral calcium, which maintains ... Vitamin D, also known as Cholecalciferol, helps absorb calcium which is essential for signaling between brain cells, ...
A Moderate Drug Interaction exists between Chelated Magnesium and cholecalciferol. View detailed information regarding this ... cholecalciferol magnesium amino acids chelate. Applies to: cholecalciferol and Chelated Magnesium (magnesium amino acids ... Ask your doctor before using cholecalciferol together with magnesium amino acids chelate. If you are undergoing chronic kidney ... dialysis treated with cholecalciferol you should avoid magnesium amino acids chelate. Using these medications together can ...
Cholecalciferol - Generated on July 19, 2019. ©2019 Memorial Sloan Kettering Cancer Center. ...
Professional guide for Alendronate and Cholecalciferol. Includes: pharmacology, pharmacokinetics, contraindications, ... alendronate 70 mg/cholecalciferol 2,800 units or alendronate 70 mg/cholecalciferol 5,600 units) once weekly. Note: The optimal ... Cholecalciferol: May not be adequately absorbed in patients who have malabsorption due to inadequate bile production. ... Wait at least 30 minutes after taking alendronate with cholecalciferol before taking any supplement. Must be taken with at ...
Detailed drug Information for alendronate and cholecalciferol. Includes common brand names, drug descriptions, warnings, side ... Alendronate and cholecalciferol can irritate your esophagus. If you think alendronate and cholecalciferol has started to damage ... It may affect the way alendronate and cholecalciferol works if you do not. Do not stop using alendronate and cholecalciferol ... Proper Use of alendronate and cholecalciferol. Alendronate and cholecalciferol comes with a Medication Guide. Read and follow ...
Easy to read patient leaflet for Cholecalciferol Wafer. Includes indications, proper use, special instructions, precautions, ... What do I need to tell my doctor BEFORE I take Cholecalciferol Wafer?. *If you have an allergy to cholecalciferol or any other ... Vitamin D Insufficiency cholecalciferol, Vitamin D3, Replesta, More.... Prevention of Falls cholecalciferol, Vitamin D3, ... Generic Name: Cholecalciferol Wafer (kole e kal SI fer ole). Brand Name: Replesta, Replesta NX ...
Cholecalciferol loading dose guideline for vitamin D-deficient adults.. van Groningen L1, Opdenoordt S, van Sorge A, Telting D ... The cholecalciferol loading dose required to reach the serum 25-OHD(3) target level of 75 nmol/l can be calculated as follows: ... Cholecalciferol in a cumulative dose of 100,000, 150,000, and 200,000 IU increased mean serum 25-OHD(3) level by 29 nmol/l (95 ... To develop a practical cholecalciferol loading dose regimen.. MATERIALS AND METHODS: A total of 208 vitamin D-deficient ...
Information about this alendronate-and-cholecalciferol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Alendronate and cholecalciferol combination is used to treat osteoporosis (thinning of the bone) in women after menopause. This ... It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination ... Use of alendronate and cholecalciferol combination is not indicated in children. Geriatric Appropriate studies performed to ...
A Minor Drug Interaction exists between cholecalciferol / iron polysaccharide and orlistat. View detailed information regarding ... Drug interactions between cholecalciferol / iron polysaccharide and orlistat. Edit this list Results for the following 2 drugs ...
Cholecalciferol meets USP testing specifications; CAS Number: 67-97-0; EC Number: 200-673-2; Synonym: (+)-Vitamin D3, 7- ... Cholecalciferol meets USP testing specifications Synonym: (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7- ...
... cholecalciferol) from other patients. Learn from their experiences about effectiveness, side effects and cost ... Showing 3 of 56 patient evaluations for Vitamin D3 (cholecalciferol) Previous page 1 2 3 … 19 Next page ...
... cholecalciferol) at PatientsLikeMe. 1505 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized ... cholecalciferol): Find the most comprehensive real-world treatment information on Vitamin D3 ( ... Showing 3 of 54 patient evaluations for Vitamin D3 (cholecalciferol) Previous page 1 2 3 … 18 Next page ...
Find patient medical information for Cholecalciferol (Vitamin D3) Oral on WebMD including its uses, side effects and safety, ... cholecalciferol (vitamin D3) 10 mcg/mL (400 unit/mL) oral drops. color. No data.. shape. No data.. imprint. No data.. This ... cholecalciferol (vitamin D3) 10 mcg/mL (400 unit/mL) oral drops. color. No data.. shape. No data.. imprint. No data.. This ... cholecalciferol (vitamin D3) 10 mcg/mL (400 unit/mL) oral drops. color. caramel. shape. No data.. imprint. No data.. This ...
Your body makes cholecalciferol when your skin is exposed to ultraviolet rays from the sun, according to MayoClinic.com. ... Cholecalciferol, also called vitamin D-3, is a fat-soluble vitamin that is necessary for the maintenance of a healthy body. ... Sources of Cholecalciferol. Cholecalciferol is added to foods such as milk, fortified breakfast cereals, margarine and cod ... Cholecalciferol Deficiency Diseases. Prolonged cholecalciferol deficiency can lead to rickets and osteomalacia. Rickets, a ...
... cholecalciferol) from other patients. Learn from their experiences about effectiveness, side effects and cost. ... Showing 10 of 56 patient evaluations for Vitamin D3 (cholecalciferol) Previous page 1 2 3 4 5 6 Next page ... 56 patient evaluations for Vitamin D3 (cholecalciferol) 380 members have decided to share their profiles only with other ...
... cholecalciferol) at PatientsLikeMe. 1450 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized ... cholecalciferol): Find the most comprehensive real-world treatment information on Vitamin D3 ( ... Vitamin D3 is the form of vitamin D called cholecalciferol. Cholecalciferol is the most widely known of the vitamin D series ... Stopped taking Vitamin D3 (cholecalciferol) Duration. Patients. This item is relevant to you: Less than 1 month 12 * 12 ...
... cholecalciferol) from other patients. Learn from their experiences about effectiveness, side effects and cost. ... 8 patient evaluations for Vitamin D3 (cholecalciferol) taken for the purpose of vitamin D deficiency with a perceived ...
  • Budesonide Epinephrine (adrenaline) Salbutamol (albuterol) Oral rehydration salts Potassium chloride Glucose Glucose with sodium chloride Potassium chloride Sodium chloride Sodium hydrogen carbonate Sodium lactate, compound solution Water for injection Ascorbic acid Cholecalciferol Iodine Pyridoxine Retinol Riboflavin Sodium fluoride Thiamine Calcium gluconateα Acetic acid Budesonide Ciprofloxacin Xylometazoline Caffeine citrate Chlorhexidine Ibuprofenα Prostaglandin EαProstaglandin E1 Prostaglandin E2 Surfactantα No listings in this section. (wikipedia.org)
  • Ask your doctor before using cholecalciferol together with magnesium amino acids chelate. (drugs.com)
  • Ask a doctor before using cholecalciferol if you have allergies , diabetes , or phenylketonuria (PKU). (emedicinehealth.com)
  • FOSAMAX PLUS D for oral administration contains 91.37 mg of alendronate monosodium salt trihydrate, the molar equivalent of 70 mg of free acid, and 70 or 140 mcg of cholecalciferol, equivalent to 2800 or 5600 international units vitamin D, respectively. (rxlist.com)
  • Each white-to-almost white, oval tablet debossed with '714' on one side contains 91.35 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 70 mg of alendronate, and 140 µg of cholecalciferol equivalent to 5600 IU of vitamin D3. (canada.com)
  • In the presence of solar ultraviolet B light, cholecalciferol is formed from a precursor molecule called 7-dehydrocholesterol. (wisegeek.com)
  • Your body makes cholecalciferol when your skin is exposed to ultraviolet rays from the sun, according to MayoClinic.com. (livestrong.com)
  • The presence of this compound in human skin enables humans to manufacture vitamin D3 (cholecalciferol) from ultraviolet rays in the sun light, via an intermediate isomer pre-vitamin D3. (wikipedia.org)
  • Certain forms of cholecalciferol may contain ingredients you should know about, such as peanut or soybean oil, sugar , aspartame (phenylalanine), or certain food dyes. (emedicinehealth.com)
  • If you have an allergy to cholecalciferol or any other part of this medicine (cholecalciferol capsules and tablets). (drugs.com)
  • You will need to talk about the benefits and risks of using this medicine (cholecalciferol capsules and tablets) while you are pregnant. (drugs.com)
  • How is this medicine (Cholecalciferol Capsules and Tablets) best taken? (drugs.com)
  • Check with your pharmacist about how to take this medicine (cholecalciferol capsules and tablets). (drugs.com)
  • Be sure you know how to take this medicine (cholecalciferol capsules and tablets). (drugs.com)
  • What are some other side effects of Cholecalciferol Capsules and Tablets? (drugs.com)
  • This new statutory formulation will allow the tablets to be packaged them in standard milk bottles that will enable pharmacies and encourage institutional customers that administer Vitamin d 400 iu tablets to store and dispense the medication in traveling a manner consistent with other possible formulations of cholecalciferol. (aktuelle-kamera.org)
  • In the liver, cholecalciferol is metabolized into calcifediol, which is further modified in the kidneys to become calcitriol. (wisegeek.com)
  • Cholecalciferol is added to foods such as milk, fortified breakfast cereals, margarine and cod liver oil. (livestrong.com)
  • Cholecalciferol is rapidly absorbed from the GI tract and transported to the liver by vitamin D binding protein. (vetstream.com)
  • synthesized endogenously in the liver in form of Cholecalciferol. (wikipedia.org)
  • Calcifediol is an example of prehormones which is produced by hydroxylation of vitamin D3 (cholecalciferol) in the liver. (wikipedia.org)
  • Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. (wikipedia.org)
  • Vitamin D3 (or cholecalciferol) is converted to 25-hydroxyvitamin D (or calcidiol) by the liver, from where it is transported via the circulation to the kidneys where it is converted into the active hormone, 1,25 dihydroxyvitamin D3. (wikipedia.org)
  • single-blinded), and to cholecalciferol therapy, 2000 vs 800 IU/d (double-blinded). (uzh.ch)
  • CONCLUSIONS: Extended PT was successful in reducing falls but not hospital readmissions, whereas cholecalciferol treatment, 2000 IU/d, was successful in reducing hospital readmission but not falls. (uzh.ch)
  • This randomized clinical trial studies how well cholecalciferol supplement works in treating patients with localized prostate cancer undergoing observation. (clinicaltrials.gov)
  • This pilot clinical trial studies cholecalciferol in treating patients with colorectal cancer. (clinicaltrials.gov)
  • Clinical studies of donepezil maleate and cholecalciferol did not either include sufficient numbers of subjects aged 65 and yearning over to determine whether perhaps they respond differently from this younger subjects. (todaysparentusa.com)
  • Clinical signs generally become apparent 36-48 hours after ingestion of cholecalciferol. (vetstream.com)
  • Though cholecalciferol and Nestabs one may be regarded as two similar drugs, there invariably are some obvious deterioration and therefore significant differences observed values when these two antituberculous drugs are studied some very closely. (todaysparentusa.com)
  • The gene product which it encodes, vitamin D 25-hydroxylase, has therefore been proposed as the key enzyme in the conversion of cholecalciferol (vitamin D3) to calcidiol. (wikipedia.org)